association	dataset	threshold value	standardized value
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9361
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51971
A-CA-04-2009(H1N1)_4day-RIPK3KO_None_GSE51526	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.70591
TALL1	CCLE Cell Line Gene Expression Profiles	1.0	1.7035
Perturb_10034_KD_PUF60_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.37759
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25378
Sarcoma_SARC_TCGA-DX-A3M2-01A-21R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
9_AAR2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.608597
hsa-miR-4658	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
LIVF001-023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77614
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.731765
BRD-K70978931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.775
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
E2F4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8135_KD_G3BP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.66224
GTEX-WFG8-1626-SM-4LVMB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90805
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2116_KD_SNRPB_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.40424
BRD-K18438502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67388
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500445
single-organism process	GO Biological Process Annotations 2015	1.0	null
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fallopiantube_8e	HPA Tissue Sample Gene Expression Profiles	1.0	1.45726
Perturb_8242_KD_SRSF7_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.19525
SKMEL5	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.91023
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22955
kidney	HPA Tissue Gene Expression Profiles	1.0	0.882555
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STRAP	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8153_KD_BOP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.96354
1489_CENPP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.642834
Perturb_6891_KD_PIRIN_SRP375440	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.3541
Perturb_8218_KD_XRCC5_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.97936
CMAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2237
STAT3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perireunensis nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20315
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35146
CTCF_keratinocyte_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PARP1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
tolmetin-4167	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.652242
8325_SPATA5L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.672572
BRD-K20377072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04202
GSE223334_3_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SP in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19208
MAX_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fipexide-5737	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SMU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5462
r3 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24812
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EW1	DepMap CRISPR Gene Dependency	1.0	2.99564
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.941951
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5263239-mmc2.xls-MV4_11_-_MLL-AF4-Non-spreading_targets_gene_names_1985_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20735575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67253
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.94679
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18834
NCIH2066	CCLE Cell Line Gene CNV Profiles	1.0	1.83781
GTF2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22872
H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
YY1_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10165_KD_DOT1L_SRP292382	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.14973
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49664
scopoletin-6510	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RARS	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903807
FOXA1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10039
amygdaloid complex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11966
SUCLG2	Pathway Commons Protein-Protein Interactions	1.0	null
2233_DIS3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.51379
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05114
hsa-miR-4777-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.6375
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RBPJ-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SPI1-22096565-GC-B-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NFE2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX50	Pathway Commons Protein-Protein Interactions	1.0	null
MYC_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832141
trichostatin A-2993	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2
mcf7	HPA Cell Line Gene Expression Profiles	1.0	1.80266
Perturb_14086_KO_USP22_SRP199797	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.1793
BRD-K14723547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22876
5250_MRPS18C_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.978412
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urinarybladder_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.54092
frontal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09928
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.46675
irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.135381
HCC2935	DepMap CRISPR Gene Dependency	1.0	2.0609
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.41004
paravermis of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.64877
Pyramus (VIII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10837
BRD-K80381603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79103
debrisoquine-3207	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OXRK-0126-SM-3NB1E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70338
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6043_PAK1IP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.670235
PF-01378883-00-6368	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40693
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100313_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.19254
EWSR1_KD_GDS4962_466_human_Ewing sarcoma and prostate cancer	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
RBM14	Pathway Commons Protein-Protein Interactions	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
inner CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17352
MAX_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8759_KO_SETDB1_SRP141213	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.182
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
vigabatrin-6314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZBTB33_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05634
EVSAT	DepMap CRISPR Gene Dependency	1.0	2.88865
THAP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
methanthelinium bromide-5780	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262389
CREB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJHI-0126-SM-4IHLP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830819
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K99525048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43834
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8443
496100645_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03049
HCC366	CCLE Cell Line Gene CNV Profiles	1.0	1.59771
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prelimbic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19984
YY1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63392
amygdalohippocampal transition zone, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.997635
BHLHE41	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5693
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07835
embryonic lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
TMEM121B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98126
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8480_KD_CSDE1_SRP117243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.41366
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2547_EIF3C_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.610075
ventral posteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43107
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01534
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MBD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930093
Perturb_3623_KO_SMARCD1_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.12411
GTEX-POMQ-0826-SM-3P61H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04185
HUH7_LIVER	CCLE Cell Line Proteomics	1.0	2.09188
Perturb_8449_KD_LETN_SRP230777	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.07609
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
basolateral amygdaloid nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14033
H3K36me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
C14orf166	Pathway Commons Protein-Protein Interactions	1.0	null
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.385881
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.33679
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0227
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08174
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01503
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3445_GNL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0759
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ribavirin_homo sapiens_gpl570_gds4391	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.84791
mitochondrial translation	GO Biological Process Annotations 2025	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UP-A6WW-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14645
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827898
H3K9ac_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K21986392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04028
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6721_KD_EHMT2_SRP043290	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.62795
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17521
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BATF	ENCODE Transcription Factor Targets	1.0	null
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5736
prednisone-4577	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3218
posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.88299
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1061
Prostatic Diseases	CTD Gene-Disease Associations	1.0	1.33791
cisapride-6706	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SRF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL5	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.WT.HP_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04528
Chromosome 4q21 deletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.47
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
A253	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.93495
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TCF7L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36037
lisinopril-2371	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W9-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14876_KO_H13_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.48095
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15026_KD_KLF11_SRP267336	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.2892
Posterior limiting nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14822
BRD-K05154886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98158
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26461
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
9816_WDR36_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.534116
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10061_KD_CCAR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.37495
Perturb_10093_KD_XRCC6_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.33424
939_BYSL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.722268
7525_RPS3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.699839
SUB1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K41172555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12777
KARPAS422	CCLE Cell Line Gene CNV Profiles	-1.0	-1.73231
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X62O-2226-SM-46MW3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88544
bufexamac-5090	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cefsulodin-2988	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K58242935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0594
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE186647,GSE217288_1_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
5550_NDUFAF7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.65319
Prestwick-984-4948	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11077
PHA 767491	DeepCoverMOA Drug Mechanisms of Action	1.0	0.69
BRD-K27902176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1262
ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
614_ATF7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.54712
GSE240027,GSE240030_5_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NCIH157DM	DepMap CRISPR Gene Dependency	1.0	2.2233
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07123
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.53583
BRD-K76450447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59909
RARS2	Pathway Commons Protein-Protein Interactions	1.0	null
PABPN1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2756
NELFE	ENCODE Transcription Factor Targets	1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.463897
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05317
hippocampus (hippocampal formation)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.969631
Perturb_14288_KD_ALKBH5_SRP272155	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.4797
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.028916
DAOY	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48663
HMEL	CCLE Cell Line Gene Expression Profiles	-1.0	-3.50663
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.14301
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.08814
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50298
hsa-miR-199b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910732
Spi1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	48.069
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TSPAN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03035
GSE166920_6_v_1_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.16836
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
ETS1	ChEA Transcription Factor Targets	1.0	null
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59652
Perturb_489_KD_DDX17_SRP360079	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.6478
GTEX-S32W-0126-SM-4AD61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75212
UHMK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00895
DOLPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56583
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63598
FUBP1	Pathway Commons Protein-Protein Interactions	1.0	null
QPCTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04698
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01585
selegiline-4065	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2781-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29092
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
macromolecular complex disassembly	GO Biological Process Annotations 2015	1.0	null
H3K4me3_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
periventricular stratum of r1BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38
SIX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
nimodipine-6320	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
palmatine-2795	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AS-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
7576_RSL1D1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.987537
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05225
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299949
NRF1	JASPAR Predicted Transcription Factor Targets	1.0	null
Lung	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.664395
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-0011-R1A-SM-3GIJO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901507
143B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.129
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.28878
mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K23435841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78203
CTCF	ENCODE Transcription Factor Targets	1.0	null
Perturb_3903_KD_HNF4A_SRP123224	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.67343
Adrenocortical carcinoma_ACC_TCGA-OR-A5JJ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165548_2_v_8_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
parasubthalamic nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20326
BRD-K72997741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40798
SEPTIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03583
NCIH747_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.92373
hsa-miR-3149	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Liver hepatocellular carcinoma_LIHC_TCGA-LG-A9QD-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIX4_01_269	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58577
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RPL31	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_2308_KD_DHX8_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.94666
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
proxyphylline-3115	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A53L-01A-21R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K03213425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16057
7559_RRN3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.841134
DDX23	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826193
CDC42	Pathway Commons Protein-Protein Interactions	1.0	null
Bed nuclei of the stria terminalis, anterior division, ventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40328
OCILY10	CCLE Cell Line Gene CNV Profiles	-1.0	-1.96521
PF-00562151-00-5922	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
gallbladder_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.943844
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.849537
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amantadine-4806	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC2157	GDSC Cell Line Gene Expression Profiles	-1.0	-1.53818
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01695
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0812
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	1.0	2.90661
liothyronine-6602	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
GSE186440,GSE186443_1_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_456_KD_SNHG17_SRP199046	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.07465
EA-18-FP00_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222451
AKT1_activemutant_9_GDS2304	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.6094
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21061
Perturb_3610_KO_BCL7B_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.65806
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48925
9210_TPP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.19466
meticrane-5984	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TAF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K51919278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02849
BRD-K21732483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64223
Perturb_8143_KD_NCBP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.6496
cuneate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12659
Mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.60567
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854247
Perturb_7453_KD_ERI2_SRP110692	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.68973
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8486_OE_PLXNB2_SRP282509	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.65606
Ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
plexiform layer of TuPal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02072
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24606
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40996
BRD-A13082766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0938
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
EGR1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92365616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4476
Perturb_9841_KD_KDM6A_SRP254623	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.2854
17660535-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61806
Cortical amygdalar area, anterior part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.66406
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PTCD3	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958682
Perturb_9909_KD_RBM17_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.7985
NCIH2004RT	DepMap CRISPR Gene Dependency	1.0	2.55449
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23645
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01762107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11595
BRD-K53488735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09771
alpha-ergocryptine-3817	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC12480102-41525_2025_515_MOESM2_ESM.xlsx-ST12-Unnamed_3_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
SETDB1_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-1026-SM-4GICL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900772
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59098
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.79878
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13528
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6848
Perturb_2600_KD_HDAC2_SRP149375	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.88042
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
metoprolol-6106	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_9828_KD_CRNKL1_SRP245546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.1518
2132_DDX56_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10213
CRCGN015_MCF10A.TP53.M_24H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0138
TRMT112	Pathway Commons Protein-Protein Interactions	1.0	null
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07819
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPD	ENCODE Transcription Factor Targets	1.0	null
BRD-K87141723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4173
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938587
dorsolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22031
SEPT2	Pathway Commons Protein-Protein Interactions	1.0	null
CALU1_LUNG	CCLE Cell Line Proteomics	1.0	12.2707
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX54	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB33_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_39_KD_ATRX_SRP308220	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.63718
GTEX-QXCU-0226-SM-2TC5W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873067
Perturb_7516_KO_TFAM_SRP213924	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.03488
Prdm5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.2527
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
urapidil-6696	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Appendix	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.29067
Perturb_7300_KO_SF3A1_SRP273617	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.98563
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05641
MAPK14_KD_GDS2693_533_mouse_A431	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SF295	DepMap CRISPR Gene Dependency	1.0	2.49515
CRCGN014_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.03573
9366_TSR2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.749551
BRD-K11893906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01303
SRPRB	Pathway Commons Protein-Protein Interactions	1.0	null
SNRPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75442
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.90029
BRD-K75076471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05807
5750_NOP58_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.944758
cytosolic part	GO Cellular Component Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61G-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7537_RPS7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.642916
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A5W6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.936787
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hela	HPA Cell Line Gene Expression Profiles	1.0	0.908058
TTLL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49818
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946699
5747_NOP16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.10888
Perturb_10026_KD_TRIM56_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.10382
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34336
Ventral posterior complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20089
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4921_MDN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.517109
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.821685
GTEX-NPJ8-0526-SM-3MJHN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04599
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5263-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5834
KIT_activemutant_55_GSE17743	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.06636
protein complex disassembly	GO Biological Process Annotations 2015	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6605_PPAN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.816407
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BHLHE40_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8051_KD_SETD2_SRP167173	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.18192
PML	ENCODE Transcription Factor Targets	1.0	null
NUSAP1	Pathway Commons Protein-Protein Interactions	1.0	null
5089_NIFK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18839
MEF2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
roxarsone-3511	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54152
HNRNPC	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
2226_DIMT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.505784
15-delta prostaglandin J2-2691	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270254
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87124
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
Entorhinal area, lateral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07941
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-2026-SM-4DM6N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863964
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.57647
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JT-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_10112_KD_FXR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.5315
GA-27-MH98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.697806
TBP	ENCODE Transcription Factor Targets	1.0	null
medial part of r1B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10521
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22239
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11211
SRF_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M8-01A-21R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932851
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.891645
SUDHL6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71496
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-MW-A4EC-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BCLAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SHMAC4	DepMap CRISPR Gene Dependency	1.0	2.24284
GSE166920_6_v_2_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
substantia nigra, pars reticulata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09842
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lorglumide-3079	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9862_KO_MYB_SRP192629	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.34724
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.4211
ergocalciferol-6746	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
7437_RPL13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05436
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
spinal trigeminal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20903
BRD-K20447569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.587
RPS17	Pathway Commons Protein-Protein Interactions	1.0	null
BFTC905	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6654
valproic acid-4438	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.32164
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22545
5730_NOC3L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.705563
midecamycin-6745	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09082
cell part	GO Cellular Component Annotations 2015	1.0	null
BRD-K72484719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18147
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16471
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.976102
EIF3E	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K17152303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38885
Perturb_6480_KD_SNRPB_ERP011528	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-XYKS-0926-SM-4BRVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45215
Liver hepatocellular carcinoma_LIHC_TCGA-QA-A7B7-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KDM6A-18722178-U937_AND_SAOS2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
5707_NMD3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.904446
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LM-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOT4-1426-SM-4B65T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06406
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1923
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.70274
principal sensory nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.979484
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.616067
GSE149075_1_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.833348
sparteine-2790	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nucleus of the central acoustic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24112
BRD-K41719231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02828
protein-containing complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K52854560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34658
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.70561
pallidal septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.05213
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.87826
Perturb_10698_KD_CD274_SRP307356	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.1944
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6308
GSE162688_3_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HB-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_7625_KD_ICE1_SRP120604	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.4442
GSE114284_2_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1648	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.10329
RPMI8402	CCLE Cell Line Gene Expression Profiles	1.0	1.38536
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HCT116_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
2544_EIF3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.753444
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CBX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04918
prenatal lethality	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68619
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.18535
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12356_KD_PRPF8_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.79226
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZC3H12C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04485
Perturb_10080_KD_IGF2BP3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.69403
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-0.945662
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.6613
Perturb_69_KD_SMARCB1_SRP280151	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.6219
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971828
CAPAN1	DepMap CRISPR Gene Dependency	1.0	2.30451
fluorometholone-5771	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8826_TEX10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.698074
TCCSUP_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	4.10309
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.955706
6-benzylaminopurine-4748	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PLAAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1163
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NEFL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05943
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.91065
Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CPSF7	Pathway Commons Protein-Protein Interactions	1.0	null
terguride-6299	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K39491844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36577
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.02341
GTEX-T5JW-1126-SM-4DM5V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877886
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prestwick-682-2164	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPS27	Pathway Commons Protein-Protein Interactions	1.0	null
OF-47-EQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255387
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CDC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15163
HDAC6	ENCODE Transcription Factor Targets	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.16852
GMP reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.644
Perturb_10052_KD_RPS19_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.79133
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.622901
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03507
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.22393
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-enclosed lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
FADU	DepMap CRISPR Gene Dependency	1.0	2.58368
7469_RPL38_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.52628
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mitochondrial inner membrane	GO Cellular Component Annotations 2023	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPL35	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-SG-A849-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34815
RAB21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30857
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.387694
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
MCM5	Pathway Commons Protein-Protein Interactions	1.0	null
Oxoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.995
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.892548
tetroquinone-4159	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.955706
Perturb_7628_KD_HNRNPL/UPF1_SRP129007	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.44021
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.21919
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_12925_KO_CLPB_SRP181053	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.57202
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K10358320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0143
hsa-miR-4686	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
PMC8593586-mmc2.xlsx-LIN28A_interactome-Unnamed_1_LIN28A	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.56845
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RM-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10110_KD_EWSR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.47204
2321_DNTTIP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.640649
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K95192796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12302
Perturb_8138_KD_IGF2BP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.84222
Perturb_14763_KD_LATS1/LATS2_SRP345234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.46114
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.2482
organelle organization	GO Biological Process Annotations 2015	1.0	null
RPL23A	Pathway Commons Protein-Protein Interactions	1.0	null
enilconazole-3139	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K32403948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88473
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.61804
Primary somatosensory area, trunk, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89194
GTEX-V1D1-0726-SM-4JBH7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86965
ChIP_RCOR3_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SHP-77	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.2515
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19086
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWOO-0326-SM-48TDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986462
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10871135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2129
Perturb_2345_KO_CGAS_ERP131756	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.95445
TRMT61A	Pathway Commons Protein-Protein Interactions	1.0	null
ovary	HPA Tissue Protein Expression Profiles	-1.0	-0.945662
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5003
SG231	DepMap CRISPR Gene Dependency	1.0	2.01921
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6302_KD_JMJD1A_SRP248223	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.05655
1040_C1ORF131_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.624232
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07095
HIST1H1C	Pathway Commons Protein-Protein Interactions	1.0	null
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7866_KO_SDE2_SRP239880	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.38295
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7433_RPL11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.636964
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.109
SARS-dORF6_0Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.89605
CDC5L	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K86838462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0607
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.41306
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X2-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.1032
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
6219_PES1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.12016
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236634
NCIH1435	CCLE Cell Line Gene CNV Profiles	1.0	2.29971
Perturb_5623_KD_SOX2_SRP307776	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.4949
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-0.945662
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB33_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
SNRNP200	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trichlormethiazide-2998	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RTCB	Pathway Commons Protein-Protein Interactions	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.688609
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1-15753290-HEK293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16054
H3K4me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HOXB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03296
RCOR3	ChEA Transcription Factor Targets	1.0	null
BRD-K69191922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47113
C19orf53	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_4916_KO_TFAP2A_SRP303667	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.1052
TP53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02671
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.839046
BRD-K44652223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4593
55S ribosome, mitochondrial	CORUM Protein Complexes	1.0	null
EIF3I	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_17552_KD_YAP1_SRP372845	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.09155
USP10	Pathway Commons Protein-Protein Interactions	1.0	null
PAC-1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.58
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TMEM109	Pathway Commons Protein-Protein Interactions	1.0	null
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE232472_1_v_2_apoe_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
macromolecule biosynthetic process	GO Biological Process Annotations 2023	1.0	null
oxantel-1277	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATF3	ENCODE Transcription Factor Targets	1.0	null
myosmine-4759	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.119
7491_RPP30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.632601
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.839012
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46721
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
8517_STK24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.36364
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.17869
BRD-K47415214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29424
Perturb_318_KD_SETX_SRP353945	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.55912
BRD-K77890526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06023
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LV-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7475_RPL5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20587
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K09250623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16806
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23271
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73115
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281619
PAX5_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estropipate-6068	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF3	ENCODE Transcription Factor Targets	1.0	null
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54899
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.85375
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	4.01117
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE186647,GSE217288_1_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
metoclopramide-4750	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06051
ETS1-20019798-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
GSE216043_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6815
STAT5A	ENCODE Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.TP53.M_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08666
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
7569_RRS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.40441
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSTF1	Pathway Commons Protein-Protein Interactions	1.0	null
GPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25527
Entorhinal area, medial part, dorsal zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12929
CHEMBL569227	DeepCoverMOA Drug Mechanisms of Action	1.0	0.46
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55359
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.6224
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57011
PMC12754469-ab-25-0159-Supplementary-1.pdf-30-SNAPC5_SNAPC5	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01244
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.860602
FOS	ENCODE Transcription Factor Targets	1.0	null
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6759
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842517
SRP14	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A7D7-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.558
Perturb_10013_KD_FKBP4_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.63585
IRF4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.35821
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
methotrexate_homo sapiens_gpl570_gse11440	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15096_KD_RELA_SRP372154	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.90997
macrophage	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.50697
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SKNO1	CCLE Cell Line Gene CNV Profiles	1.0	1.60613
UPCISCC131	DepMap CRISPR Gene Dependency	1.0	2.17641
Primary visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64062
CRCGN013_HEPG2_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2662
H3K36me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEx Thyroid 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-5.28151
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26422
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11966
JUN	ENCODE Transcription Factor Targets	1.0	null
S0-EE-Y79N_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229588
GTEX-SNOS-1226-SM-4DM5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15388
TK	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.27119
hsa-miR-376c	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_10212_KD_SETX_SRP353945	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.41608
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
placenta	HPA Tissue Protein Expression Profiles	-1.0	-0.945662
KCNK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54304
intracellular organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LS-411N	GDSC Cell Line Gene Expression Profiles	-1.0	-1.73801
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0124
SKLU1	CCLE Cell Line Gene CNV Profiles	1.0	3.24835
FLI1	ChEA Transcription Factor Targets	1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K22865069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60396
PANC-10-05	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5938
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE253041_3_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEx Heart 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-9.30656
alvimopan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.2
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23729
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33406
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
Crus 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60525
estradiol_homo sapiens_gpl570_gse23610	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K46877890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37371
Mitochondrial translation	Reactome Pathways 2024	1.0	null
PMC3371315-NIHMS350140-supplement-8.xls-MCF7-T47D-SK-453_Down_MCF7-T47D-Supplementary_Table_1_ER-positive_FOXA1_signature_Genes_decreased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.3986
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Anterior cingulate area, dorsal part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0483
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.55792
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-0526-SM-3K2BC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43135
Mitochondrial proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.032
DIS3	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7077-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8339-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.27459
bone marrow	HPA Tissue Protein Expression Profiles	-1.0	-0.945662
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.37945
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.05003
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42103
Lung squamous cell carcinoma_LUSC_TCGA-33-A5GW-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.53283
PEER	CCLE Cell Line Gene CNV Profiles	1.0	2.10474
BRD-K65780164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09115
Perturb_5349_OE_Dux_SRP201141	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.92675
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THRAP3	Pathway Commons Protein-Protein Interactions	1.0	null
4994_METTL16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578771
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.938
Perturb_17614_OE_FOXP2_SRP225889	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_6291_KO_ZNF165_SRP390251	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.97154
HNF4A	ENCODE Transcription Factor Targets	1.0	null
SKMES1	CCLE Cell Line Gene CNV Profiles	1.0	1.40275
GTEX-QDVJ-1126-SM-48U1U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04834
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHUEM1	DepMap CRISPR Gene Dependency	1.0	2.01877
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18804
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05118964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21992
5730_NOC3L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.059
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36454
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240888
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.04388
posteroventral (inferior) parietal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.83522
7509_RPS19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51049
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
T47D	DepMap CRISPR Gene Dependency	1.0	2.31933
BRD-K32373560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5411
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRF_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SLR26	CCLE Cell Line Gene Expression Profiles	-1.0	-1.86763
GSE111138,GSE111149_1_v_0_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5436
7497_RPS10-NUDT3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.523425
ZEB1	ENCODE Transcription Factor Targets	1.0	null
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prelimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43931
7537_RPS7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.712136
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Piriform-amygdalar area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08548
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_unique_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
Field CA3, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04351
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SKM1	CCLE Cell Line Gene Expression Profiles	1.0	1.4872
r5 part of magnocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39398
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.23238
prostate_4c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.90986
GSE215086_3_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.66798
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.961126
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CKAP4	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_2294_KD_DDX5_SRP139509	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.80861
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T8EM-1826-SM-4DM7F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862841
RKO	CCLE Cell Line Gene Expression Profiles	1.0	2.08493
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EJ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_10431_KD_circFAT1_SRP261305	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.70663
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975811
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0926-SM-2HMIZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885272
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.22041
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.33467
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206449
methyldopa-4677	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cisplatin_homo sapiens_gpl570_gds3910	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHCHD1	Pathway Commons Protein-Protein Interactions	1.0	null
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5861
ikarugamycin-918	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.03953
NCI-H1793	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.88972
GTEX-S341-0526-SM-4AD5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54895
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_12541_KD_UGT2B17_SRP166340	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.82731
GTEX-SIU7-0226-SM-4BRX2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39066
peripeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21001
GTEX-XUJ4-0126-SM-4BOP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27699
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
Perturb_8197_KD_TRIM56_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.67721
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38334
GSE166944_0_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nucleus of the posterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00505
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7913
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.38427
TE11	DepMap CRISPR Gene Dependency	1.0	2.0308
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13835
dipyridamole-5617	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ATP5F1	Pathway Commons Protein-Protein Interactions	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEx Stomach 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-5.01643
GSE240027,GSE240030_1_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RCC4	CCLE Cell Line Gene Expression Profiles	-1.0	-1.86375
3-acetylcoumarin-5259	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01091
BRD-K83619973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25578
KMBC2	DepMap CRISPR Gene Dependency	1.0	2.22398
9818_WDR3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560033
GATA3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0353
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.540436
proglumide-3972	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QEG5-1426-SM-447AS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08877
MRS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01806
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58301
Perturb_5635_KD_JQ1_SRP142503	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.03179
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.71679
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.924
kanamycin-3224	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsolateral prefrontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.843317
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.874927
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE172146_2_v_1_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
translational initiation	GO Biological Process Annotations 2015	1.0	null
GATA1_G1E-ER4_mm9_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03308716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36897
spinalcordupper	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.898384
Perturb_2516_KD_YAP1_SRP181909	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.60671
H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_11_ZZZ3_ChIP-seq_in_shZZZ3-Genebody_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
dr9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.623
organellar small ribosomal subunit	GO Cellular Component Annotations 2015	1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.584411
5738_NOL9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.1651
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCoV-EMC2012_24Hour_23631916_GSE45042	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.37796
GTEX-QEG5-0926-SM-2TC64	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940957
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A21524347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61158
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR3-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28348
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951845
GSE217363_5_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7561_RRP12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.731902
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
desoxycortone-6758	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_9905_KD_SSB_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.7171
MIAPACA2	DepMap CRISPR Gene Dependency	1.0	2.33706
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.5413
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dentate (lateral) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13571
VDR	ChEA Transcription Factor Targets	1.0	null
anterior cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.16781
CEBPD_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cefoperazone-6323	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
probucol-5261	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YN-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.025068
Perturb_15402_KD_MELK_SRP098926	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.83854
PMC12522211-NIHMS2104691-supplement-MMC1.xlsx-SRCAP_DE_genes-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
2114_DDX27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.583601
H3K4me1_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
A-CA-04-2009(H1N1)_18Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.66186
BRD-K35119180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16518
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874523
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19015
MAFF	ENCODE Transcription Factor Targets	1.0	null
U2SURP	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_2075_KD_PUM1_SRP072710	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.52108
SPI1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EPRS	Pathway Commons Protein-Protein Interactions	1.0	null
bendroflumethiazide-3758	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HS819T	CCLE Cell Line Gene Expression Profiles	-1.0	-2.07771
SRF	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KW-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38032
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K76713927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51908
7442_RPL18A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.598812
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adrenal gland	GTEx Tissue Gene Expression Profiles	1.0	2.18987
7435_RPL13A_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.621814
parvicellular (lateral) subparafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67451
PRPF3	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_16777_KO_Utx/Jmjd3_SRP339500	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.33297
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255677
Pancreatic adenocarcinoma_PAAD_TCGA-2L-AAQA-01A-21R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
neostigmine bromide-6735	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K53443314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84648
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21035
ventrolateral prefrontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.928807
HEP3B217_LIVER	CCLE Cell Line Proteomics	1.0	2.03254
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2847
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PANC0203	CCLE Cell Line Gene CNV Profiles	1.0	1.39621
GSE195568_6_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0622
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12457
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.992968
NANOG	ENCODE Transcription Factor Targets	1.0	null
WSUNHL	DepMap CRISPR Gene Dependency	1.0	2.0772
AIMP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4067
7445_RPL21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.889763
7427_RPF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.734851
5738_NOL9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.604755
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intermediate stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4771
danazol-5315	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
fallopiantube_8d	HPA Tissue Sample Gene Expression Profiles	1.0	0.832336
tonsil_8b1	HPA Tissue Sample Gene Expression Profiles	1.0	1.07842
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20748
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.41158
TET1	ChEA Transcription Factor Targets	1.0	null
GSE89767_7_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.832674
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A7HU-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HDLBP	Pathway Commons Protein-Protein Interactions	1.0	null
SNU423	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63712
SGPL1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial translation elongation	Reactome Pathways 2014	1.0	null
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.98324
structural molecule activity	GO Molecular Function Annotations 2015	1.0	null
Prestwick-674-4738	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thyroid_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.05728
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.15747
BRD-K07600484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31781
spleen	HPA Tissue Protein Expression Profiles	-1.0	-0.945662
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.35684
H4K5ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC2157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.854848
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1	ChEA Transcription Factor Targets	1.0	null
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48764
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932155
PPIG	Pathway Commons Protein-Protein Interactions	1.0	null
PPP1CA	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.86457
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211935
FBXO45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51507
Perturb_7291_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.6997
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OB-06-WW76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.996744
Field CA1, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29903
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.40008
BRD-K87670244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03342
MDAMB468_BREAST	CCLE Cell Line Proteomics	1.0	3.92136
BRD-K14255526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21405
7461_RPL34_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.910344
Perturb_8758_KO_SETDB1_SRP141213	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.45311
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.48571
OVKATE	CCLE Cell Line Gene CNV Profiles	1.0	2.51475
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nomegestrol-5461	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CACNA1H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41695
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
orciprenaline-4831	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPS11	Pathway Commons Protein-Protein Interactions	1.0	null
USF1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7427_RPF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.715356
medial tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9891
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6445_KO_YAP_SRP134183	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.8557
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07172
SUDHL10	DepMap CRISPR Gene Dependency	1.0	2.10169
PAX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7522_RPS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.696653
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.05757
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.69498
BRD-K75900952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66065
ZFYVE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37702
DARS2	Pathway Commons Protein-Protein Interactions	1.0	null
9839_WDR74_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.04462
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LAMA2_Deficiency_GDS3371_595_mouse_Hind limb skeletal muscle (4-week old dy3K/dy3K animals)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC8752721-42003_2021_2991_MOESM4_ESM.xlsx-Fig3_ZFPM1-gene_ZFPM1	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.6446
NAA38	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16262
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13784_OE_IL10RB_SRP329434	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.91708
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.52864
cefotiam-6762	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6590-01A-12R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36865
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36445
anterior tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95212
LDHA	Pathway Commons Protein-Protein Interactions	1.0	null
DU145	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.41159
Brain Lower Grade Glioma_LGG_TCGA-DU-6410-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3862_HNRNPDL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.549509
Perturb_12367_KD_SLC39A7_SRP274341	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SW837	GDSC Cell Line Gene Expression Profiles	-1.0	-1.53724
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29871
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994515
RXRA	ENCODE Transcription Factor Targets	1.0	null
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	1.0	2.39675
TDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3616
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thyroid	GTEx Tissue Gene Expression Profiles 2023	1.0	5.31116
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67262
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRS 2578	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.95
noscapine-2745	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11057
superficial stratum of PPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09438
TMEM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64483
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UBXN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00771
7444_RPL19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.763269
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26513
SERBP1	Pathway Commons Protein-Protein Interactions	1.0	null
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.930004
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976744
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_17806_KO_ZNF675_SRP304971	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.45278
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73497584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61358
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.544732
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ATP5C1	Pathway Commons Protein-Protein Interactions	1.0	null
SKG-IIIA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SHISA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19031
5089_NIFK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.23182
NB7	DepMap CRISPR Gene Dependency	1.0	2.6871
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41802
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.833751
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CB-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_JARID1A_20064375	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3042_FCF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.845832
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.787499
HEK 293 T-rex    	BioGPS Cell Line Gene Expression Profiles	1.0	0.877796
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_14161_KD_BZW1/BZW2_SRP316321	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.47973
septohypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44837
RPL38	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K92613860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16443
Perturb_14874_KO_H12_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.3263
H3K27ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Mitochondrial large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.82
BRD-K40655550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05165
septopallidal shell area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.14365
2127_DDX51_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.06875
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.820495
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.3548
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SJRH30	GDSC Cell Line Gene Expression Profiles	1.0	1.83901
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5140203-908	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
outer CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.834049
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-KDM5B-Unnamed_3_KDM5B	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XOTO-2826-SM-4B65I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957625
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76387
Perturb_3848_KD_lncRNAAK096729_SRP192850	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
pralidoxime-5383	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MD-91-JM80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258616
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3374-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perhexiline	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.27
BRD-K46970272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14592
Perturb_10099_KD_HNRNPU_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.76229
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09324
BRD-K53387776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00272
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54964
3447_GNL3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.992845
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17251
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2190_KD_ETS2_SRP083762	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.54
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SND1	Pathway Commons Protein-Protein Interactions	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SEM	CCLE Cell Line Gene Expression Profiles	1.0	1.59596
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.72037
Poisoning	CTD Gene-Disease Associations	1.0	1.09751
mitochondrion	LOCATE Curated Protein Localization Annotations	1.0	null
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kinetin-6073	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30039
G3BP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	3.40216
RANBP2	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-A5DJ-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
flunisolide-3923	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FLI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A776-01A-13R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4684_LSG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.21608
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K26087938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43116
NCIH1838	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48716
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fosfosal-4239	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A23340824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38831
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE162739_6_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB33_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.954904
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS14	Pathway Commons Protein-Protein Interactions	1.0	null
Mafg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.7265
Perturb_12738_KD_TCF7L1_SRP094619	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.71981
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20342
GABPA_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9883_KD_CPEB4_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.37538
PMC10830421-41589_2023_1452_MOESM5_ESM.xlsx-HEK293T_MAX-Tg_tissues-Unnamed_0_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LDHB	Pathway Commons Protein-Protein Interactions	1.0	null
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949128
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.98396
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09107
HSC39	DepMap CRISPR Gene Dependency	1.0	2.60862
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-MB-A5Y8-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
anteroventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0469
BRD-K62979806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72122
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX17-20123909-XEN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A34891365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70437
1483_CENPJ_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.838421
serotonin-5268	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Field CA3, stratum pyramidale	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10013
2102_DDX10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512232
Perturb_16004_OE_HOXA13_SRP107176	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.48433
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-1826-SM-2YUNC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930483
mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE145311_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_2077_KD_PUM2_SRP072710	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.24641
GTEX-W5WG-1126-SM-4LMK4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48421
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-101	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333849
GTEX-PSDG-1126-SM-2S1ON	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13029
RPL22	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67516
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-MI-A75C-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9884_KD_DDX47_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.08325
7480_RPL8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.777783
Perturb_4904_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
CRCGN016_MCF10A.TP53.M_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4015
Perturb_10022_KD_PSIP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.53761
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4597
Perturb_4789_KD_Firre_ERP009127	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.75016
MRPL11	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.57044
Lung squamous cell carcinoma_LUSC_TCGA-39-5028-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20042
BFTC905	DepMap CRISPR Gene Dependency	1.0	2.7636
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.836665
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2C	Pathway Commons Protein-Protein Interactions	1.0	null
pyrithyldione-2740	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.837907
BRD-K55465787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74755
BRD-K25016708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27615
SA-32-CC58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.296598
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
decreased embryo size	MGI Mouse Phenotype Associations 2023	1.0	null
Perturb_11345_KD_ZRANB1_SRP119864	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.60507
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5365_MYBBP1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.676805
tanespimycin-2666	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K27035180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62201
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
nicotinic acid-6702	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A5Y0-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0581
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2096
SRSF3	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_15527_OE_CPT1A_SRP292168	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.03042
mediodorsal nucleus of thalamus_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36919
GTEX-XMK1-0226-SM-4B65D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53814
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MRPS35	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K81124412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0455
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN011_HEPG2_24H:I20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80165
GTEX-TKQ2-0226-SM-4DM6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24636
BRD-K47175449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2634
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
milrinone-3552	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DARS	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K20426211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51413
SKBR3	CCLE Cell Line Gene CNV Profiles	1.0	1.36512
Mediodorsal nucleus of the thalamus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44977
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9864_KO_MYB_SRP192629	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.72511
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.294869
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18272
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE241862_0_v_3_cabozantinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CDK5_knockdown_99_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.66272
9684_UTP20_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.605033
ETS1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-1426-SM-3NB1T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997355
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.10023
Perturb_2563_OE_GATA3|JUN_SRP188712	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.70909
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.29997
Organellar ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Visual cortex disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
Perturb_342_KD_GDF6_SRP076553	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
PMC12824906-mmc5.xlsx-Sheet1-Table_S4_Target_genes_of_FOXM1_and_their_expression_across_the_subtype_of_breast_tumors_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.865646
K562_Cediranib_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162743
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2028
BRD-K64425085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11819
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
MRPS7	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PWOO-0526-SM-2S1Q3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892931
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
MAX_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
appendices_4b	HPA Tissue Sample Gene Expression Profiles	1.0	0.882778
9366_TSR2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.962028
BRD-K49656278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62766
dorsomedial hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09011
SRF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92736140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39763
GABP-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.897131
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.364805
substantianigra	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00252
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0415
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7313
BRD-K05465626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10287
SJRH30	CCLE Cell Line Gene CNV Profiles	1.0	1.85755
SUPT20H	ENCODE Transcription Factor Targets	1.0	null
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.4166
PRPF6	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F1-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_1795_KD_Bud13_SRP168625	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.78077
3677_HEATR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.916393
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superior parietal lobule, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.914887
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49656
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3329-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_439_KD_MEP50_SRP073189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.58883
Perturb_9850_KO_PTPN2_SRP214323	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.2039
GTEX-XMK1-1726-SM-4B64Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09055
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXM1	ENCODE Transcription Factor Targets	1.0	null
BRD-K55169051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43419
RNF187	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03475
SP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.73957
SOX17-20123909-XEN-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SRSF6	Pathway Commons Protein-Protein Interactions	1.0	null
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.496969
Perturb_13691_KD_NSD2_SRP064418	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.97038
ALG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38283
Perturb_2317_KD_PRPF31_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.1859
mitochondrial translational termination	GO Biological Process Annotations 2015	1.0	null
DNAL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0327
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.33388
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4EP-0011-R2B-SM-3P625	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91654
GTEX-T8EM-1226-SM-4DM5J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947451
HT144	DepMap CRISPR Gene Dependency	1.0	2.12145
API5	Pathway Commons Protein-Protein Interactions	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126463_4_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE214442_0_v_1_pak4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33937
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65351
GTEX-P4PP-1526-SM-3P61M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828547
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.07804
ATF3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS3A	Pathway Commons Protein-Protein Interactions	1.0	null
HNF4A	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A	Pathway Commons Protein-Protein Interactions	1.0	null
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.82059
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71996
Aiolos_NULL MUTATION_GDS3473_572_mouse_Bone marrow pre-BII cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-RU72-0326-SM-2TF5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39206
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.87955
shsy5y	HPA Cell Line Gene Expression Profiles	-1.0	-1.65178
Perturb_10045_KD_EIF3D_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.5217
lambdoid septal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02183
GTEX-QEG5-0626-SM-2S1PP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08706
atropine methonitrate-6495	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K94241935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10577
USP27X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42927
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.86402
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
inner SZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11435
A375SKINCJ2	DepMap CRISPR Gene Dependency	1.0	2.12361
Ribosomal protein S18	InterPro Predicted Protein Domain Annotations	1.0	null
Sarcoma_SARC_TCGA-K1-A6RV-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_7596_KO_PRPF39_SRP389969	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.6431
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00038
TT	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46353
LARS	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
accessory entopeduncular nucleus (post-migratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22246
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF3A	Pathway Commons Protein-Protein Interactions	1.0	null
Paraflocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61153
ATP6V0E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61233
BF-27-HP68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.432775
MEF2C_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIST1H1E	Pathway Commons Protein-Protein Interactions	1.0	null
gene expression	GO Biological Process Annotations 2023	1.0	null
Mitochondrial small ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CUX1	ENCODE Transcription Factor Targets	1.0	null
mexiletine-2324	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
C-33 A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.884268
lateral parabrachial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.78642
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70808
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6365
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.85516
Perturb_14903_KO_PRMT6_SRP125977	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.04188
ZSCAN18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06911
4921_MDN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.00048
basolateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.25078
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.96435
FUS	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF135	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89956
Prestwick-642-4594	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
1614_CINP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.807037
COR-L279	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-5.54149
eucatropine-3935	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_3_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53168433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26156
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.96094
BRD-K30264389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20521
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GM-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K49577636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34509
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215506
PMC7616765-EMS198548-supplement-Data_S2.xlsx-3_DEG_2D_and_3D-D9_Up_in_2D_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
PKNOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75346
7312_RIOK2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.752074
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1111
BRD-K41709602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15025
medial parabrachial nucleus,right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.891143
TOX4	Pathway Commons Protein-Protein Interactions	1.0	null
cotinine-5611	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_10015_KD_HNRNPC_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PF-04418948	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.25
RERF-GC-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32062
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.881323
496100406_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.53023
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K25257305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40854
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K62182950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31195
7480_RPL8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19947
tremorine-5799	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24606
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874133
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12796
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.787553
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.954904
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M5-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39600742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01443
SIN3A_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889383
KYSE70	DepMap CRISPR Gene Dependency	1.0	2.27937
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Perturb_8283_KD_BCLAF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.08718
Perturb_3603_KO_ARID1A_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.47388
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.35772
SRSF5	Pathway Commons Protein-Protein Interactions	1.0	null
Acquired Immunodeficiency Syndrome	HuGE Navigator Gene-Phenotype Associations	1.0	null
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.49627
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pyrantel	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2748
Perturb_8799_OE_HOTAIR_SRP352837	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.44314
cell junction	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02134
GTEX-U4B1-0326-SM-3DB8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0243
BRD-K36778976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22346
nucleus of the diagonal band, left, horizontal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38131
ATF3-23680149-GBM1-GSC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
4108_IMP4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.924999
RPS2	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5577301-in-17-237-s001.xls-AR_upregulated_DEGs-Liver_GSE13440_GENE_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4QT-1326-SM-3NMD3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827129
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EIF4B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7SF-0426-SM-3K2B7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1683
H3K79me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
2983_FAU_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.719723
7508_RPS19BP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.755954
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.06449
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ELF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70214
carbachol-3380	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1422
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SMN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32541
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90879
Perturb_553_KD_KDM5A_SRP277893	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
7478_RPL7L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.915285
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75474
BRD-K12376164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11442
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.946567
USF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
erythromycin-6729	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5037-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926217
REDD1_Repression_GDS3558_73_human_Blood Myeloid Cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Medial group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02395
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3440-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25554
POU5F1-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14104_KD_HNRNPC_SRP274546	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.76197
lung_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.84764
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_unique_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
E2F4_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELK4_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPT6-0126-SM-4B65S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865123
ASPH	Pathway Commons Protein-Protein Interactions	1.0	null
gossypol-4762	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.16468
AIM1	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE186287_2_v_0_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HdhQ111/111_Knock-in_GDS4534_744_mouse_Striatum and cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
tilorone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20069
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.944653
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.996139
GSE217132_0_v_1_pfkfb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60184
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K99546030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29726
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7448
ventral linear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74383
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_2_ZZZ3_occupied_genes-ATAC1_bound_genes_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Disease Progression	HuGE Navigator Gene-Phenotype Associations	1.0	null
SNRPD3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K14536501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32797
Perturb_8794_KD_AML1ETO_SRP384263	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.28207
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
viomycin-3541	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.39568
Prelimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.16032
BRD-K73540839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76455
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWN1-1526-SM-48TDA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910783
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.51501
GSE165334_3_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.20939
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5746_NOP14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.574604
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCIMY5	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42727
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CA-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dydrogesterone-2156	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_9899_KD_EIF3G_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.93567
CSDE1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K36me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Perturb_8241_KD_SRSF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.4235
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18262
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933129
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.556
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K25559116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30419
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-CoV NSP16_Day2_None_GSE49263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.56913
Acute Myeloid Leukemia_LAML_TCGA-AB-2803-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nitrendipine-6464	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
7479_RPL7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.714224
GTEX-XGQ4-1526-SM-4AT6H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81557
7474_RPL4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.681355
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4673
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-RA-A741-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LS411N_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	5.35529
SNU1041	DepMap CRISPR Gene Dependency	1.0	2.91687
TFB2M	Pathway Commons Protein-Protein Interactions	1.0	null
ATF2	ENCODE Transcription Factor Targets	1.0	null
isoetarine-7170	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.86955
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prestwick-967-2925	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2023	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-A4BD-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC0403	CCLE Cell Line Gene CNV Profiles	1.0	1.41808
SAFB2	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25731
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13748
LN428	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83194
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16686
NRF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03564
SIX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01422
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82323
phenformin-4747	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP2509	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.41
Secondary motor area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35528
NCCSTCK140	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49493
superficial stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22481
Te	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.73
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2163
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48578
BRD-K25380480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55665
amygdalohippocampal transition zone, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.957575
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZC3H15	Pathway Commons Protein-Protein Interactions	1.0	null
CAL27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50002
TET1-21490601-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7109_OE_Sirt5_SRP364867	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.61147
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.588624
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
superior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03587
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
USF2_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nuclear part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842517
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946785
Perturb_14891_KO_H15_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.79395
MAP4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE92965_0_v_1_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
U937	DepMap CRISPR Gene Dependency	1.0	2.27185
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226114,GSE226116_2_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HNF4A	ChEA Transcription Factor Targets	1.0	null
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.42184
GTEX-S4Q7-0226-SM-4AD5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11618
personality disorder	GWASdb SNP-Phenotype Associations	1.0	0.799025
Intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF3C	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_9976_KD_G3BP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.01508
BRD-K53772256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13929
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.80625
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-542-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Perturb_738_KD_MBNL1_SRP139891	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.59838
Htk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.704
nomegestrol-6362	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65212
peptide biosynthetic process	GO Biological Process Annotations 2023	1.0	null
Perturb_16092_KD_RRM2_SRP398748	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.46158
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52051
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851666
Swi5-Sfr1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.991
GTEX-OHPL-1326-SM-3MJGG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16184
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
CALU3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58706
layer 2 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01753
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994288
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.21855
BUD31	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K35667841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67416
7439_RPL15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500632
USF2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H520	GDSC Cell Line Gene Expression Profiles	-1.0	-1.69714
7482_RPLP0_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.803069
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1	ChEA Transcription Factor Targets	1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Supplementary_Table_2_Differentially_expressed_genes_upon_knockdown_of_SUFU_compared_to_control_in_HCC1954_cells_Related_to_Figure_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20398543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35867
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29944
9804_WDR12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.48417
Perturb_6432_OE_RBFOX1_SRP372391	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.61117
Perturb_9637_KO_CHCHD2_SRP212876	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.02166
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.9768
FBL	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6363-01A-21R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
alfaxalone-5451	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
7523_RPS3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.602201
doxazosin-3024	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17897
metamizole sodium-3754	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNB75	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.830164
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S32W-2526-SM-2XCB8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931377
MST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06361
TFEB-21752829-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-1246	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Sarcoma_SARC_TCGA-MB-A5YA-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE118532_0_v_1_rnf168_human	RummaGEO Gene Perturbation Signatures	1.0	null
Diabetic Neuropathy_Sciatic Nerve_GSE11343	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.61971
RBM27	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K99939253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63665
GFI1B	ChEA Transcription Factor Targets	1.0	null
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE144231_6_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU-5	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.6378
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HNRNPR	Pathway Commons Protein-Protein Interactions	1.0	null
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68695
FLI1	ENCODE Transcription Factor Targets	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FASTKD2	Pathway Commons Protein-Protein Interactions	1.0	null
vinpocetine-3174	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K80212510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46939
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12803
Brain Lower Grade Glioma_LGG_TCGA-HT-7616-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8056_KD_IGF2BP1_SRP094100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.75529
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.335432
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SARS-CoV MA15_Day7-PFU-10^5_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.96755
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.885764
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-0.945662
H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1319_KO_IRF4_SRP201368	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.54983
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07211
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LA-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.8548
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HSD17B4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K06573818	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50027
Perturb_8479_KD_CSDE1_SRP117243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.90004
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48037
ioversol-6726	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cortical amygdalar area, posterior part, medial zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.325
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16935
RECQL	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K33956641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.153
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6R0-01A-12R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-7979-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.946354
BRD-K25877330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11582
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
umbilicalcord	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.865729
SRSF11	Pathway Commons Protein-Protein Interactions	1.0	null
NFYB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC59	DepMap CRISPR Gene Dependency	1.0	2.26106
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6436-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF4-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.981493
Cortical amygdalar area, anterior part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36351
Mitochondrial translation termination	Reactome Pathways 2014	1.0	null
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.73262
Prostate adenocarcinoma_PRAD_TCGA-J4-A67L-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K44430448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27903
Perturb_3594_KO_DELE1_SRP218218	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.40667
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.39929
GTEX-WEY5-0526-SM-3GIKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969984
translation	GO Biological Process Annotations 2025	1.0	null
Combined oxidative phosphorylation deficiency 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.648
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11443
paraterete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.3164
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.904802
YY1-23942234-MYOBLASTS AND MYOTUBES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_635_KO_SOX4_ERP117895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.39301
RPL36A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K46890865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11966
UE-50-KK32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235401
outer CP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.952325
SRSF1	Pathway Commons Protein-Protein Interactions	1.0	null
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24879
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06373
Perturb_15635_KO_MAT2A_SRP351305	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.3817
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.830351
gramine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11266
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BB-52-LF37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.359897
Perturb_826_KD_REST_SRP093671	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.3644
NCIH1355	CCLE Cell Line Gene CNV Profiles	1.0	1.49077
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5104
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46F-01A-31R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
789_BCCIP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.7457
AGMAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40096
ZBTB33_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
furosemide-6841	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SETDB1	ENCODE Transcription Factor Targets	1.0	null
7498_RPS10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.578192
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXA1_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.91753
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K14ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98140933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29782
macromolecular complex subunit organization	GO Biological Process Annotations 2015	1.0	null
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.17138
GSE120336_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_6435_KD_HOXA10AS_ERP131886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.57188
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.047075
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.870243
C1QBP	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-3179	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284878
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
HNRNPD	Pathway Commons Protein-Protein Interactions	1.0	null
5250_MRPS18C_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.03277
GATA1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
u698	HPA Cell Line Gene Expression Profiles	1.0	0.970408
GSE231648_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9972_KD_BCLAF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.84341
Perturb_12570_KD_MSI1_SRP185353	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.96464
fludrocortisone-3866	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854247
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39859
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-TML8-1326-SM-4DXTO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15459
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914593
4208_ISG20L2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.542456
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.919467
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.54279
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_8189_KD_HNRNPF_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.49954
PMC10323888-MOL2-17-1356-s001.pdf-4-GLI3_GLI3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE109913_1_v_2_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09858
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
KPNB1	Pathway Commons Protein-Protein Interactions	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
5365_MYBBP1A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.678747
GTEX-T6MO-0126-SM-4DM6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04249
levopropoxyphene-3543	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TGDS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03869
ATF3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8227_SNRPC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.607254
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19925
Perturb_8092_KD_PUF60_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.1524
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.0706
Aggressive periodontitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
primary motor cortex (area M1, area 4)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08677
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A852-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XE-01A-12R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22244754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10703
perifornical nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.978219
5747_NOP16_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05604
OVOL2_01_313	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.5932
macromolecule biosynthetic process	GO Biological Process Annotations 2025	1.0	null
9971_ZBTB14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.07197
GTEX-VUSG-1526-SM-4KKZH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930412
GSE121198,GSE129782_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X585-2426-SM-46MW2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946647
H3K27ac_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10078_KD_ZC3H8_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.09426
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K79me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RPL8	Pathway Commons Protein-Protein Interactions	1.0	null
7576_RSL1D1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.610278
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-2.08644
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A58937872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01719
Perturb_8256_KD_RACK1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.59926
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89501
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.9427
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LSM7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K26689527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12697
POLR2A_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19049
KB-48-GH25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233709
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.03738
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	1.0	1.71788
isosorbide-4742	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05114
organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
RPS12	Pathway Commons Protein-Protein Interactions	1.0	null
ATF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10544
GTEX-XXEK-0626-SM-4BRWE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987274
H3K27me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS28	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.16599
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2838
ALDOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43877
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34637
RPL26	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.422294
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.881816
BCLAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10095_KD_AGO2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.01903
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE119978,GSE180930_0_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEx Colon 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-19.2986
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
Perturb_12924_KO_CLPB_SRP181053	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.50676
BRD-K40432489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00538
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.87598
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR1C	Pathway Commons Protein-Protein Interactions	1.0	null
CPSF6	Pathway Commons Protein-Protein Interactions	1.0	null
ANXA2	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8131_KD_EIF2S1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.87973
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MF-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBPJ	ChEA Transcription Factor Targets	1.0	null
Perturb_89_KO_SNORD74_ERP116971	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.51664
PMC12697907-ADVS-12-e07451-s002.xlsx-ST4E_MR-pancanQTL-Unnamed_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85567359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44721
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.00342
BRD-K67090705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03332
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GPX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47862
SW780	CCLE Cell Line Gene CNV Profiles	-1.0	-2.86506
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
28S ribosomal subunit, mitochondrial	CORUM Protein Complexes	1.0	null
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14518
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_2_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
USF1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7460_RPL32_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.986461
ctnnb1_21565795_adrenocortical_adenomas_lof_mouse_gpl570_gds3912	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.00375
RUNX3	ENCODE Transcription Factor Targets	1.0	null
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.267
salivary gland	HPA Tissue Gene Expression Profiles	-1.0	-0.873722
Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K52225720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12242
GTEX-S3XE-0126-SM-4AD4R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50281
GSE94849_3_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
bufexamac-2382	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Oligospermia	CTD Gene-Disease Associations	1.0	1.04941
Anterior cingulate area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32973
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.903872
Intergeniculate leaflet of the lateral geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16786
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8752721-42003_2021_2991_MOESM4_ESM.xlsx-Fig3_E2F2-gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LXF289	CCLE Cell Line Gene Expression Profiles	-1.0	-2.04906
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5729_NOC2L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.709965
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.05151
HNRNPAB	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48803
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
coralyne-6317	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A624-01A-22R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18804
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73261251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06312
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
mediodorsal nucleus of thalamus_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.840522
SF3B3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38557431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94618
ELK1	ENCODE Transcription Factor Targets	1.0	null
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.646761
CTCF_MCF-7_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1237	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5659_NGDN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.710067
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0473
isopropamide iodide-6781	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.21631
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90259
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5256
GTEX-U4B1-1026-SM-4DXT1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21331
BRD-K93101873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13615
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29858
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.870533
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.155
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.00072
protein metabolic process	GO Biological Process Annotations 2025	1.0	null
Perturb_2515_KD_TEAD4_SRP181909	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.09254
neuropeptide-S nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32389
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.03241
Perturb_7637_KD_DOT1L_SRP292382	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.18103
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22623
GSE155567_1_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.29347
TRIM33_knockdown_304_GSE32903	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.50749
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC11019654-Supplementary_Data5.xlsx-Sheet1-Table_SV_The_RBP_genes_associated_with_both_NONHSAG037054_2_and_GABPA_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.63524
EXOSC4	Pathway Commons Protein-Protein Interactions	1.0	null
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149264,GSE149267_4_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIX5_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE94849_7_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61943
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.357
5734_NOL12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.66355
septostriatal transition area (accumbens)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08367
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47578
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945243
H3K27ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FAM120A	Pathway Commons Protein-Protein Interactions	1.0	null
clofilium tosylate-6830	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_7587_KO_ALKBH5/FTO_SRP362871	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.87513
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
USF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism organelle organization	GO Biological Process Annotations 2015	1.0	null
GSE172146_2_v_0_mettl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ATF2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MET	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23108
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861008
mitochondrion organization	GO Biological Process Annotations 2015	1.0	null
BRD-K25846934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95581
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Unnamed_1_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_432_KD_RPAP3_DRP004966	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.57798
3042_FCF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.540806
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVN-0426-SM-48TZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974332
Perturb_8098_KD_TUFM_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.87684
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.698247
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-556-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
Organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
EBF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K63743653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46882
7432_RPL10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00026
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.39755
GTEX-S4UY-0006-SM-3K2A7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02112
BRD-K77965546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55988
CHD2	ENCODE Transcription Factor Targets	1.0	null
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61525
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_7541_KO_NSUN6_SRP273753	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.67554
TSC22D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0762
SIRT6	ENCODE Transcription Factor Targets	1.0	null
HNRNPUL2	Pathway Commons Protein-Protein Interactions	1.0	null
EWSR1	Pathway Commons Protein-Protein Interactions	1.0	null
NRF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889961
ribonucleoprotein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25512
TRIM28	ENCODE Transcription Factor Targets	1.0	null
PAX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A43076080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36618
H3K4me1_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4PQ-0626-SM-3NMCU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974882
Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9127_OE_YAP_SRP090747	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.6748
BRD-K99447506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5958
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1_G1E-ER4_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9165_KD_circCAMSAP1_SRP366297	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.05459
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37976
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.136
TUBB	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_10097_KD_CNOT8_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.28104
aminophylline-5395	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.824413
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854557
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LH-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Geniculate group, dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09305
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A41A-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXP3-21729870-TREG-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28975
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIX5_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE180147_0_v_1_itga5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
stomach	HPA Tissue Protein Expression Profiles	1.0	1.24651
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-ZJ-A8QQ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47200630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18624
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MARS	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K13206026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24294
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAX5_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.825533
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3Q8-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28389
ZNF263	ENCODE Transcription Factor Targets	1.0	null
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_2546_KD_EZH2_SRP067706	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.291
RPS10	Pathway Commons Protein-Protein Interactions	1.0	null
EBNA2-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40552
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A857-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pedunculopontine nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03039
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_3629_KO_HDAC3_SRP355605	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.61889
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A8RZ-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36701
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.987739
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KARS	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_15163_KD_PGR_SRP097736	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.30466
A-CA-04-2009(H1N1)_0Hour_None_GSE37571	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.23877
8291_SOX3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563194
oxprenolol-3568	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
globus pallidus, external segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.843048
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.90745
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DEOC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.925711
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
7540_RPSA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.56024
5504_NCL_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.567878
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32468
BRD-K67353973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06762
Lung squamous cell carcinoma_LUSC_TCGA-66-2771-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5939
cetirizine-4815	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
M14	GDSC Cell Line Gene Expression Profiles	-1.0	-1.50444
Perturb_2337_KD_WBP11_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.29538
GTEX-TMMY-0126-SM-4DXTP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06692
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915979
SNU886	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85624
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.8226
7432_RPL10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.831791
6493_PNO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.529495
indoprofen-3007	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A673	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71362
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	1.0	2.62432
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.62585
Lateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12366
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K49681465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31503
Perturb_3620_KO_SMARCA4_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.8393
GTEX-X8HC-0726-SM-46MWG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844104
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842517
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF3H	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.955239
BRD-K95648552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40934
enalapril-7026	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_2906_OE_MACROH2A2_SRP333362	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.48708
hsa-miR-4673	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GTEX-U4B1-0826-SM-4DXTW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834687
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5649_KD_MYBL2_SRP161768	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
TDRD5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AI-0226-SM-48U1D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07146
Perturb_10138_KO_PRPF40B_SRP197235	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.7227
0317956-0000-3777	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU466	CCLE Cell Line Gene Expression Profiles	-1.0	-2.09967
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4678
Perturb_13706_KD_SMARCA2_SRP247495	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.28616
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0767
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-2.06055
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.90368
NSUN2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K00409424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55074
MITF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9178
Perturb_3515_KD_EIF4A3_ERP130710	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.1426
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.72299
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5866
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleolus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
JARID1A-20064375-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.2717
ETS1	ENCODE Transcription Factor Targets	1.0	null
BRD-K36176998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7231
mitochondrial translation	GO Biological Process Annotations 2023	1.0	null
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.87872
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.74632
hsa-miR-371-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
outer SZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.913369
BFTC905	CCLE Cell Line Gene CNV Profiles	-1.0	-2.35705
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6493_PNO1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.500464
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_14885_KO_H12_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.0323
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM167A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56988
Perturb_14148_KO_KBTBD4_SRP279638	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.08288
SARS-ddORF6_84Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.74657
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2104
Crus 2, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60736
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.944292
GTEX-RM2N-0126-SM-48FDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07274
Primary somatosensory area, trunk, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39879
periventricular stratum of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45712
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cyclopenthiazide-2905	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K46715415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31048
Perturb_9891_KD_HSPD1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.52273
clonidine-4478	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.876355
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.913494
Lung adenocarcinoma_LUAD_TCGA-67-3773-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4543_KD_Chd4_SRP126769	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.68716
HS 895.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.39276
paraseptal subpallium	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06652
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16947
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.75301
Endometriosis_Endometrium_GSE7305	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.50017
HCC-44	COSMIC Cell Line Gene Mutation Profiles	1.0	null
carteolol-3276	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A688-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.955767
small ribosomal subunit rRNA binding	GO Molecular Function Annotations 2023	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.45358
Perturb_10017_KD_LARP7_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.61164
CD3EAP	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8205_KD_PCBP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.02025
7426_RPF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.660218
Ribonucleoprotein complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
4499_LAMB1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.621205
GABPA_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTBP2	ENCODE Transcription Factor Targets	1.0	null
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.904802
Perturb_9402_KD_MYCN_SRP104120	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.43754
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5185-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11844807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27639
MOLT4	BioGPS Cell Line Gene Expression Profiles	1.0	1.32405
CRCGN016_MCF10A.TP53.M_24H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10117
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
7481_RPL9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1515
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CPSF1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14841
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.86848
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.22621
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79965
Pyramus (VIII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02499
7422_RPAP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507615
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AHNAK	Pathway Commons Protein-Protein Interactions	1.0	null
GSE227592_13_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.99513
815_BDP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.549801
HSPA9	Pathway Commons Protein-Protein Interactions	1.0	null
Ziprasidone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.49
PAP-1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.61
Perturb_2998_KD_BRD2_SRP302197	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.01572
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2731_ESF1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.645246
AA-58-FJ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227649
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23896
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.051913
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09439
PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
TA-20-FO62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35769
BRD-K95521279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12372
MRPS11	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36796440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5011
7312_RIOK2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.536801
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE250534_0_v_3_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10606_KO_Abcc9_SRP132855	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.50261
KDM5A	ENCODE Transcription Factor Targets	1.0	null
BRD-K52379519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14686
Perturb_8634_KO_Htr6_SRP223109	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.34512
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842517
GTEX-UJHI-0826-SM-4IHLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29082
BRD-K16919185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01055
primary motor cortex (area M1, area 4)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67262
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K57059449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22526
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83645749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51942
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-0426-SM-3NMCI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12383
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39346
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.84142
DDX47	Pathway Commons Protein-Protein Interactions	1.0	null
GSE164874_5_v_14_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67658
ATF3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GEMIN5	Pathway Commons Protein-Protein Interactions	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF3B	Pathway Commons Protein-Protein Interactions	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.9525
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FMR1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QMRM-1226-SM-447C6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922893
GTEX-XV7Q-0826-SM-4BRV7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33413
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PPP1R10	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8208_KD_RBM34_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.48187
Perturb_13921_KO_PPARGC1A_SRP314654	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.96829
A-CA-04-2009(H1N1)_0Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.49191
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS29	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_7801_KD_PAF1_SRP064356	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.85421
Perturb_13013_KO_ALOX5_SRP367905	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.819
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216912
RELA	ENCODE Transcription Factor Targets	1.0	null
JHH6	DepMap CRISPR Gene Dependency	1.0	2.34877
Perturb_5656_KD_CT_SRP201842	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.1237
demecarium bromide-5795	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18492
SCC9	DepMap CRISPR Gene Dependency	1.0	2.16201
BRD-K06219419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40988
hsa-miR-3065-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81J-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SART1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-7140-01A-41R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19786
USF1_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7458_RPL30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25114
BRD-K65932559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12071
BRD-K31408750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05544
Lung adenocarcinoma_LUAD_TCGA-78-7163-01A-12R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4371_KIAA1958_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.636139
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7453_RPL26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.37787
hydroxyachillin-4797	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLGALT1	Pathway Commons Protein-Protein Interactions	1.0	null
7467_RPL37A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.27782
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.33003
BRD-K26559753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21832
Perturb_825_KD_REST_SRP093671	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.95983
ajmaline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1201
SLIRP	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05859
BRD-K92124212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95972
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05755
1301_CCDC86_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.06974
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3604_KO_ARID1A_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.0456
TMEM214	Pathway Commons Protein-Protein Interactions	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3391
CPT1A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51113
CELF1	Pathway Commons Protein-Protein Interactions	1.0	null
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.852327
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K56759808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7477
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.22166
gene expression	GO Biological Process Annotations 2025	1.0	null
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07729
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21702
Olfactory organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.982
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8130_KD_DDX6_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.42861
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.01667
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.596354
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Piriform-amygdalar area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72058
Primary somatosensory area, upper limb, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03187
BRD-A06232236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47787
7577_RSL24D1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.915812
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24095
betonicine-4767	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RT11284	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37959
Perturb_9311_KD_Trp53_SRP320074	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.04901
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0787
18768393-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9253713-mmc3.xls-sufu_KD_HCC1954_DEGs-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-483-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-K70695911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19876
AC-93-LT43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.491023
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.45396
Entorhinal area, medial part, dorsal zone, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48818
BRD-K27323347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11917
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE118766_2_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_13653_KD_CELSR2_SRP149837	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.183
Mitochondrial translation termination	Reactome Pathways 2024	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO320	CCLE Cell Line Gene CNV Profiles	1.0	1.59276
FOXP2	ENCODE Transcription Factor Targets	1.0	null
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.553523
7577_RSL24D1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.823676
Perturb_14184_KO_KDM1A_SRP289469	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.3693
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
33_ABCF1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.708205
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23712
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DD-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_astrocyte of the spinal cord_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
0179445-0000-4758	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CSTF2	Pathway Commons Protein-Protein Interactions	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.61101
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10172325-41598_2023_34728_MOESM5_ESM.xlsx-KD_Upregulated-Unnamed_0_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29537
CEBPB	ENCODE Transcription Factor Targets	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.49999
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.646286
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WHWD-0426-SM-3LK83	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880456
TARDBP	Pathway Commons Protein-Protein Interactions	1.0	null
HNRNPM	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC4090731-bjc2014262x1.xls-Sheet1-CaSig-HSF1_Positive_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
2-aminobenzenesulfonamide-5422	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
colistin-4796	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Copula pyramidis, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05062
SF3A2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.35562
OCUB-M	GDSC Cell Line Gene Expression Profiles	-1.0	-1.933
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.56999
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2603
BST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02114
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.44751
GTEX-P4PQ-1526-SM-3NMCK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902638
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.48449
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-0.945662
4472_KRR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.719693
7525_RPS3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.781802
ERBB2_druginhibition_8_GDS2139	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.63188
SYNE1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R53T-0226-SM-48FEH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941792
Kidney renal clear cell carcinoma_KIRC_TCGA-3Z-A93Z-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
3447_GNL3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.50744
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TGFBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34944
Perturb_3972_KD|Mut_SFPQ|BRAF_SRP258593	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.1272
E2F1-26619117-HEPATOCYTES-MOUSE-LIVER	ChEA Transcription Factor Targets 2022	1.0	null
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.60995
EPZ004777	DeepCoverMOA Drug Mechanisms of Action	1.0	0.41
decreased circulating creatinine level	MGI Mouse Phenotype Associations 2023	1.0	null
hsa-miR-1283	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2347
TBX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21603
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.738
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7870-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
7442_RPL18A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.745133
SQ1	CCLE Cell Line Gene CNV Profiles	1.0	1.72902
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LIVF001-005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04991
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.529758
ALYREF	Pathway Commons Protein-Protein Interactions	1.0	null
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5592
Perturb_7634_KD_DOT1L_SRP078067	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.18103
GATA1_G1E-ER4_mm9_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.06266
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308068
Lung adenocarcinoma_LUAD_TCGA-80-5611-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-94-7033-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13683_KD_FTO_SRP116935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.37336
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
LAD1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
corynanthine-4811	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BCL3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24463
G3BP2	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8258_KD_RCC2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.58758
BRD-K30019337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10603
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4696-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.18287
Medial septal complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35014
mitochondrial part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
gabexate-4804	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59191599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37534
GTEX-V955-0326-SM-4JBGV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861027
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K86454955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3573
EP300_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.1253
697	GDSC Cell Line Gene Expression Profiles	1.0	1.58635
superficial stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87789
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89966
BRD-K14489740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1826
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IS-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
ATN-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.34044
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74512976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52707
HK2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.8112
TCF7L2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZCCHC8	Pathway Commons Protein-Protein Interactions	1.0	null
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.0818
GSE239844_4_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rosiglitazone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
oxybenzone-6309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.215
Perturb_10077_KD_WRN_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.62482
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZM-0226-SM-4DXTA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36638
Perturb_6879_KD_LINC00857_SRP371132	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.65577
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3704
sertaconazole-3550	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCAR1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mitochondrial gene expression	GO Biological Process Annotations 2025	1.0	null
HEC50B	DepMap CRISPR Gene Dependency	1.0	2.05565
TAF7	ENCODE Transcription Factor Targets	1.0	null
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.59685
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.12212
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20F-06A-21R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A73559168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24231
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
Perturb_4541_KD_Baz2a_SRP126769	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.89866
MELHO	DepMap CRISPR Gene Dependency	1.0	2.22038
YY1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.17202
dorsal entopeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09333
SF3B1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K45077605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63947
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3143	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
PAX5	ENCODE Transcription Factor Targets	1.0	null
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49147
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U2AF1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
intracellular non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE188570,GSE188571_5_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE92589_0_v_1_sirolimus_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIST1H4F	Pathway Commons Protein-Protein Interactions	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
CEBPB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82107433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6576
1013_C18ORF32_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.572312
ETS1-20019798-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NFYA	ENCODE Transcription Factor Targets	1.0	null
HCC56	DepMap CRISPR Gene Dependency	1.0	2.75924
PMC11399095-44161_2024_532_MOESM7_ESM.xlsx-Sheet1-Supplementary_Table_6_DEG_of_hyperexpanded_clones_in_EAT_vs_AA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
8738_TBL3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.525132
infection	GAD High Level Gene-Disease Associations	1.0	0.293278
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
USF1_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.752844
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UI-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NPJ8-0011-R1a-SM-33HCB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889042
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tcof1_15522210_neuroblastoma_gof_mouse_gpl339_gds998	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.088281
lateral mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22536
globus pallidus, internal segment, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.925124
SOX3-22085726-MUSCLE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348949
Perturb_532_KD_TCF4_SRP234742	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.56494
GATA1_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9824_WDR46_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.536782
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-0008-SM-4GICH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909435
KYSE-410	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cilengitide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.59
496100305_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19796
organelle part	GO Cellular Component Annotations 2015	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14024
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYBS-1226-SM-3NM9N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10604
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.59118
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.889923
RUNX1	ChEA Transcription Factor Targets	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838875
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cellular component organization	GO Biological Process Annotations 2015	1.0	null
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.97222
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842517
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38022
Perturb_14878_KO_H14_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.32684
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10128_KD_eHDAC6_SRP090317	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.94992
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNRPD2	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7467_RPL37A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574111
RBM3	Pathway Commons Protein-Protein Interactions	1.0	null
island of Calleja major	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.23008
lateral septal nucleus, intermedio-intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46319
BRD-K99833695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15697
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE255432_7_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SUPT5H	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_599_OE_HOTAIR_SRP342161	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.77944
TENM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39385
KE39	CCLE Cell Line Gene CNV Profiles	1.0	1.89567
GSS	DepMap CRISPR Gene Dependency	1.0	2.27279
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30658
RPL21	Pathway Commons Protein-Protein Interactions	1.0	null
decreased hemoglobin content	IMPC Knockout Mouse Phenotypes	1.0	null
r5 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3262
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pallidum, medial region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38546
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNRNP70	Pathway Commons Protein-Protein Interactions	1.0	null
IRF3	ENCODE Transcription Factor Targets	1.0	null
OSGIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04148
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11295
3409_NOP53_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.662539
NCIH1437	DepMap CRISPR Gene Dependency	1.0	2.00257
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74315
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24352
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201887
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-38-QC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246925
COLO678	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77296
Perturb_9969_KD_WDR3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.52306
propafenone-5437	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38924
Perturb_478_KD_PPARGC1A_SRP278736	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.28721
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.429
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.45705
t47d	HPA Cell Line Gene Expression Profiles	-1.0	-1.07816
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FAM98B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_3559_KD|OE_NOTCH3|MYC/HHEX_SRP174604	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.38322
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.5437
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15802
Perturb_46_OE_ERG/MYC_SRP069177	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.61256
USF1	ENCODE Transcription Factor Targets	1.0	null
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ribosome	KEGG Pathways 2026	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
oxedrine-3578	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hydrocortisone-6684	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_8216_KD_TRA2A_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.47211
GSE134214_0_v_1_ell2_human	RummaGEO Gene Perturbation Signatures	1.0	null
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27818
REST	ENCODE Transcription Factor Targets	1.0	null
POLD1	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-577	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
SF3B4	Pathway Commons Protein-Protein Interactions	1.0	null
7445_RPL21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.27567
ZW10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86845
BRD-K01166365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77126
6237_PFDN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.518921
QB-35-FO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228492
Clorgiline	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.8
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.87379
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7539_RPS9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.65071
PK45H	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55659
guanadrel-2575	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-VJYA-0526-SM-4KL1R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29671
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HM-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RRP12	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917318
H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cisplatin_homo sapiens_gds3910	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-UPIC-1026-SM-4IHLT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937151
EIF3M	Pathway Commons Protein-Protein Interactions	1.0	null
RPS15A	Pathway Commons Protein-Protein Interactions	1.0	null
7500_RPS12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.558098
acacetin-3849	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NR2F2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ranitidine-5425	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17480_KO_IGF2BP1_SRP277076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
7648_SAP18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.514369
496100488_TCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04276
FOXA2	ENCODE Transcription Factor Targets	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SHMT2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35548
Prostate adenocarcinoma_PRAD_TCGA-KK-A7B2-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4208_ISG20L2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.17842
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.889383
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.595151
Prestwick-689-6076	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51296348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0114
Dorsal part of the lateral geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87174
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.86138
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201631
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.55262
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01737
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.598193
lincomycin-2380	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4553
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17451
H3K79me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
2580_EIF6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.947021
MRPS2	Pathway Commons Protein-Protein Interactions	1.0	null
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS7	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
tail of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.892236
flavoxate-5427	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE139455_7_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
DDX1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.16742
GSE125014_6_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02768
GTEx AdiposeTissue 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-13.0023
vitamin c_homo sapiens_gpl570_gds3635	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
TGBC11TKB	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80496
hydroxyamphetamine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30427
K562_BMS-754807_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218075
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41841
Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A6C0-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
EW-1	GDSC Cell Line Gene Expression Profiles	1.0	1.79454
RXRA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31023
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
HES3_KO_GSE64449_186_mouse_Min6	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
Perturb_10043_KD_EEF2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.2955
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00873
2132_DDX56_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.11721
Lhx8	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.7538
USF1_A549_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medrysone-3603	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7_Tucidinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00983543
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMK1-1326-SM-4B65Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7305
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.99406
9841_WDR75_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.840674
lateral subdivision of area 9	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.967754
hycanthone-3229	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20532
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70703
decreased hemoglobin content	MGI Mouse Phenotype Associations 2023	1.0	null
D423MG	DepMap CRISPR Gene Dependency	1.0	2.93526
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE195568_1_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AKT1_activemutant_216_GSE9484	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.73031
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-male_port-EGR1_1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43288
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21226
Perturb_10135_KD_RNPA1_SRP141197	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_8185_KD_DNAJC2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.13027
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09068
intracellular organelle part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Dyskinetic cerebral palsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.848
BCL3	ENCODE Transcription Factor Targets	1.0	null
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_461_KD_HNRNPK_SRP238505	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.66783
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.352043
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10495
SIN3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTPBP10	Pathway Commons Protein-Protein Interactions	1.0	null
quinpirole-3539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14606
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	1.0	0.961169
propidium iodide-6104	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCIH510	DepMap CRISPR Gene Dependency	1.0	2.54844
POLR2D	Pathway Commons Protein-Protein Interactions	1.0	null
RUSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2243
organellar small ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Perturb_12726_KO_MITF_SRP255094	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.06513
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247575
BRD-K08431704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33712
PMC12000322-41419_2025_7601_MOESM11_ESM.xlsx-H3122_AR_Nonsynonymous_mutation-SYMBOL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_11475_KO_MUC1C_SRP402838	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.4172
HNRNPA0	Pathway Commons Protein-Protein Interactions	1.0	null
GSE157594_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A762-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
prenatal lethality	IMPC Knockout Mouse Phenotypes	1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3564
RPS25	Pathway Commons Protein-Protein Interactions	1.0	null
4523_LAS1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.630144
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21737
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957332
HCC1576	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1534
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NONO	Pathway Commons Protein-Protein Interactions	1.0	null
chr4_83484592_T_C_b38	GTEx eQTL 2025	1.0	2.08178
CBX3	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7,8-Dihydroxyflavone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.65
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-1126-SM-48TBU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941513
WH-4-023	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.72
USF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8278
PTRF	Pathway Commons Protein-Protein Interactions	1.0	null
Auditory capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.232
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVCAR-4	GDSC Cell Line Gene Expression Profiles	-1.0	-1.75691
Odanacatib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
JUND	ENCODE Transcription Factor Targets	1.0	null
WDFY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03813
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56501
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10221669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27404
GTEX-R55E-1026-SM-2TC5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2681
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K66670355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41315
HMGN3	ENCODE Transcription Factor Targets	1.0	null
BRD-K25199508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28431
flumetasone-3610	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K46065636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15494
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05141
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09723
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF15	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K78983822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57671
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23339
FOXA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPDL	Pathway Commons Protein-Protein Interactions	1.0	null
KCTD12	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PGGHG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10771
GSE231891_3_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.57926
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3484
BRD-K92655427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04019
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5Q6-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_WI38_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO-678	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.47883
TICRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06981
foliosidine-6057	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_3142_OE_CXADR_SRP274008	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.63441
tretinoin-2671	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC10214295-mmc4.xlsx-B_-_Beta_Cell_ZBTB16_targets-Ensembl_Gene_ID_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
PNU-0230031-4754	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTF2B	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HNRNPU	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_7202_KD_DHX9_SRP080966	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.5823
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0826-SM-4DXSZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06683
Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LGI4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38245
GSE244072_4_v_6_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854247
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31145
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.28301
Perturb_6872_KD_YAP1/WWTR1_SRP323378	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.65845
salivarygland_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.876415
TNNC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52374
7463_RPL35_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.864857
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decreased erythrocyte cell number	IMPC Knockout Mouse Phenotypes	1.0	null
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9849_KO_PTPN2_SRP214323	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.0308
TGBC11TKB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48384
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SNOS-0626-SM-4DM5F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917972
PPARalpha_OE_GDS2289_244_mouse_Skeletal muscles	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MEF2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26548
Perturb_72_KD_DNTM3B_SRP315598	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.52337
lower basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03822
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	1.0	2.28303
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836419
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
palmatine-4957	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Spz1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.75
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08757
BRD-K65399214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11983
Perturb_7626_KD_UPF1_SRP120604	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.49133
FAU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26038
Organellar large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.815
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4703
Perturb_1298_KO_SOX15_SRP049465	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.40193
BRD-K79329532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31912
YY1-23942234-MYOBLASTS-AND-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32322
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14879
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74864
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31218
BRD-K75710654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23817
Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cortical amygdalar area, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.91282
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880925
8744_TBRG4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.667983
EBNA2-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tiapride-2331	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
wortmannin-869	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MFE296	DepMap CRISPR Gene Dependency	1.0	2.55825
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7044-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8232_KD_ZC3H8_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.23702
DDX56	Pathway Commons Protein-Protein Interactions	1.0	null
anterior nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.779
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
benperidol-4196	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_8368_KD_IGF2BP3_SRP094100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.2923
dorsal raphe nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03736
superficial stratum of r5BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42347
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
core part of DTg	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05168
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.18007
UBTF	ENCODE Transcription Factor Targets	1.0	null
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.856776
DHX9	Pathway Commons Protein-Protein Interactions	1.0	null
Prestwick-1103-6019	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JUN_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14194_KO_ALPG_SRP277076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.0556
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3706
cefepime-6237	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
central nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.950746
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.80643
6574_POP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574407
OD-96-OP94_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212476
ENSG00000286190	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29368
cytosolic small ribosomal subunit	GO Cellular Component Annotations 2015	1.0	null
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.946677
CCDC174	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17006
Lung adenocarcinoma_LUAD_TCGA-49-4486-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4512-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
phenazopyridine-6100	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
subethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42411
GTEX-SIU7-0526-SM-3NM8I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31976
ZBTB8OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27454
MBD4_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45375
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K52083268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00303
BRD-K56258950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37172
ZNF263	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24236
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QCQG-0126-SM-48U27	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00169
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89465
Mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A61V-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.583345
MZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.053
GTEX-RU1J-0326-SM-46MUM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52173
GSE114258_1_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WYBS-1126-SM-3NMAM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885398
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.0797
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34511
496100333_FWM_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06945
Perturb_13785_OE_IL10RB_SRP329434	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.7223
5548_NDUFAF5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.64275
cellular protein complex disassembly	GO Biological Process Annotations 2015	1.0	null
496100613_TCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14051
RPL23	Pathway Commons Protein-Protein Interactions	1.0	null
7509_RPS19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.696039
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88551
FOXA1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K88856685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25659
decreased hematocrit	IMPC Knockout Mouse Phenotypes	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6799
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12146
Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6215_PELP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51552
layer 1 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12791
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07038
GSE86507,GSE86509_4_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
alpha-estradiol-1048	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10007_KD_HNRNPA1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.94249
hsa-miR-4328	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26531
FF-28-ES17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243002
AC-41-IB85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.556428
MRPS14	Pathway Commons Protein-Protein Interactions	1.0	null
glycocholic acid-6716	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
amphotericin B-5404	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
orbital frontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14113
1192_CARF_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.946562
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8046-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hydroquinine-5789	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201929
CHD1	ENCODE Transcription Factor Targets	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A72W-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0075
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_10_ZZZ3_ChIP-seq_in_shNT-Genebody_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
SLR21	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73345
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6434_KD_HOXA10AS_ERP131886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.76136
DDX46	Pathway Commons Protein-Protein Interactions	1.0	null
PPARG	ChEA Transcription Factor Targets	1.0	null
BRD-K47052171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62727
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.497541
FUBP3	Pathway Commons Protein-Protein Interactions	1.0	null
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.337
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.5984
5750_NOP58_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.585227
subthalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58589
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.785379
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207784
IRF4	ENCODE Transcription Factor Targets	1.0	null
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23401
Lung squamous cell carcinoma_LUSC_TCGA-85-A4JB-01A-51R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206421
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.406369
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11599
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.953847
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K38788176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3394
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.45832
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.6605
SPI1-22096565-GC-B-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70198986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36754
6219_PES1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.852988
prochlorperazine-5575	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDELR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19721
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5657_KD_EF1_SRP201842	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K03958924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04947
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
practolol-3204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4081
PPIE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09588
JUND_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus of Barrington	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28632
KPL1	DepMap CRISPR Gene Dependency	1.0	2.54035
PC3_PROSTATE	CCLE Cell Line Proteomics	1.0	3.92136
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
7459_RPL31_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.02001
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.876991
Perturb_15463_OE_BHLHE22_SRP380212	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.82172
NVL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27445
IFNGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11368
Perturb_4330_KD_PTGS1_SRP055392	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.1566
ERH	Pathway Commons Protein-Protein Interactions	1.0	null
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.877792
subgranular zone of caudal dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60927
5734_NOL12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.61754
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFATC1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cortical amygdalar area, posterior part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33211
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03047
2456_EBNA1BP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.851373
PMC12260418-pnas.2425984122.sd01.xlsx-TEAD4_6fraction_test_result-Unnamed_3_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
methyl-salicylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01582
ONS-76	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71664
Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28737
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	1.0782
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
2551_EIF3G_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.547611
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67A-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00804
BRD-K48279074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39503
aminophylline-3036	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.941634
USF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.32252
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUDUL1	CCLE Cell Line Gene Expression Profiles	1.0	1.60034
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04789
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.02
7497_RPS10-NUDT3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.522077
496100323_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.2764
BRD-A89554862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23565
Perturb_9926_KD_SRSF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16606
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24606
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.52127
Perturb_9151_KD_DDX21_SRP327839	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.34761
RBM42	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4457
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_467_KD_ADAR1/ADAR2_SRP253895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.055
GTEX-WRHU-0226-SM-3MJFV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852871
RS5	CCLE Cell Line Gene Expression Profiles	-1.0	-2.15003
EIF4H	Pathway Commons Protein-Protein Interactions	1.0	null
KHSRP	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_14306_KD_SRSF1_SRP230637	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.40388
H2BK120ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-U8T8-0126-SM-3DB94	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891859
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7468_RPL37_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.706412
GTEX-WZTO-0426-SM-3NM99	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908084
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.17996
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958879
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6605_PPAN_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.607607
BRD-K57476199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09299
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261436
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.89696
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dl-alpha tocopherol-4961	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04271
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14251
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.946507
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78119
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KDM6A-18722178-U937-AND-SAOS2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
OVKATE	CCLE Cell Line Gene Expression Profiles	1.0	1.49918
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.66262
BRD-K26237438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20472
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13537
Perturb_6785_KD_USP42_ERP121305	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.02844
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
heart muscle	HPA Tissue Protein Expression Profiles	1.0	1.24651
BRD-K67137502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17415
imatinib_homo sapiens_gpl96_gds3048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28911
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3713
BATF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938673
Perturb_17202_KD_HOTAIRN_SRP159658	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.66559
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ganciclovir-5389	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4879
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32266
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09203
VCAP	CCLE Cell Line Gene CNV Profiles	1.0	1.34095
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19838
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX17	ChEA Transcription Factor Targets	1.0	null
Perturb_12945_KD_METTL3_SRP106608	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.3527
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.850375
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Perturb_4860_KD_BAF47_SRP188516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.15015
5673_NIP7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.697245
denatonium benzoate-6502	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EP300_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K11905754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51852
GSE196104,GSE196106_2_v_0_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K28488100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18483
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.926121
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
PABPC1	Pathway Commons Protein-Protein Interactions	1.0	null
spiradoline-4553	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40737
DDX6	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.78395
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.155
NCI-H2596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.876284
PMC5740759-40246_2017_131_MOESM1_ESM.xlsx-Table_S2-HSF1_CanSig_Genes-HSF1-CanSig_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
ATF3-23680149-GBM1-GSC-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5673_NIP7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.739005
Perturb_7182_KD_MED26_SRP164752	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.43798
Perturb_810_KD_LINCADL_SRP100501	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.37733
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216507
A-Vietnam-1203-2004(H5N1)_0Hour_21865398_GSE28166	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.27103
hippocampus (hippocampal formation)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.83032
Perturb_8057_KD_IGF2BP3_SRP094100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.6178
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.44285
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98741
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_9027_KD_lncFAM_SRP377217	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.44152
IQGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.03355
Perturb_12492_KD_PELP1_SRP351131	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.07685
Perturb_6444_KO_MRTFA_SRP134183	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.67337
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28935
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28149
GTEX-WRHK-1426-SM-3MJF9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84953
Perturb_10159_KO_ZNF598_SRP269441	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.31346
GTEX-QMR6-1926-SM-32PL9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865599
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal motor nucleus of the vagus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.904523
primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.840115
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mitochondrial ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
decreased erythrocyte cell number	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S4Z8-0126-SM-4GICC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06473
DDX17	Pathway Commons Protein-Protein Interactions	1.0	null
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2143
Lung squamous cell carcinoma_LUSC_TCGA-33-A4WN-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
butamben-5792	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SIX5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16075
NFYB	ENCODE Transcription Factor Targets	1.0	null
7169_RBM28_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.68766
ARID3A	ENCODE Transcription Factor Targets	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02741
NR2F2	ENCODE Transcription Factor Targets	1.0	null
EXOSC5	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT	Rummagene Transcription Factor Associations 2026	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.80265
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.01739
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64434
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K23232542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31553
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2722	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.954904
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z1-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cortical blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05881
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS4X	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB33_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFC4	Pathway Commons Protein-Protein Interactions	1.0	null
famprofazone-3753	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Fenoldopam	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
Mitochondrial translation elongation	Reactome Pathways 2024	1.0	null
POLR2I	Pathway Commons Protein-Protein Interactions	1.0	null
NELFB	Pathway Commons Protein-Protein Interactions	1.0	null
H3K36me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
digoxigenin-3397	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC7801680-41598_2020_79740_MOESM9_ESM.xlsx-BCL6_target_genes_in_N1-PEF1_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60437668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37927
GSE193588_1_v_2_pax3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nobox_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.010322
Perturb_563_KD_MYCN_SRP158473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.47539
WBSCR22	Pathway Commons Protein-Protein Interactions	1.0	null
flupentixol-6708	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
eGFP-FOS_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TT1TKB	DepMap CRISPR Gene Dependency	1.0	2.46167
Perturb_8210_KD_RTF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.30337
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36229
primary auditory cortex (core)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.41009
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26436
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17795
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWCY-0226-SM-48TD8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17726
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-543	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
BRD-K31606237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03595
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13864_KD_KDM6B_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00727
ZBTB33_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BICR78	DepMap CRISPR Gene Dependency	1.0	2.14618
RBM15	Pathway Commons Protein-Protein Interactions	1.0	null
ACCMESO1	CCLE Cell Line Gene Expression Profiles	1.0	2.06278
7713_SDAD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.690498
Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HT-01A-12R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7460_RPL32_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.621877
0317956-0000-3774	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
(S)-(-)-Pindolol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventral posterior medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08756
Six3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.1631
U251MGDM	DepMap CRISPR Gene Dependency	1.0	2.69965
Perturb_7508_OE_ILF2_SRP195616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.64578
SIX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALVA31	BioGPS Cell Line Gene Expression Profiles	1.0	1.36315
intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
organelle inner membrane	GO Cellular Component Annotations 2023	1.0	null
ZBTB33_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 4 of ERCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28973
USF2	ENCODE Transcription Factor Targets	1.0	null
COL17A1	Pathway Commons Protein-Protein Interactions	1.0	null
UPCISCC116	DepMap CRISPR Gene Dependency	1.0	2.5138
BRD-K38190084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14645
POU2F2	ENCODE Transcription Factor Targets	1.0	null
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49207
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.93296
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86767
thioridazine-5590	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WHSC1	ENCODE Transcription Factor Targets	1.0	null
GLTSCR2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183941
amprolium-4241	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EEF1E1	Pathway Commons Protein-Protein Interactions	1.0	null
Mammary myoepithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.374
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.127
HSQ89	DepMap CRISPR Gene Dependency	1.0	2.00718
H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04562
Perturb_14202_KD_KLF5_ERP117894	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.06993
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCL3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nrf-1	MotifMap Predicted Transcription Factor Targets	1.0	null
7713_SDAD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0002
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25946
Bosentan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.52
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4131
H3K27ac_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XUZC-0226-SM-4BOO7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.191
MAX	ENCODE Transcription Factor Targets	1.0	null
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18806
PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12234789-41467_2025_61560_MOESM3_ESM.xlsx-Supplementary_data_1-Only_YY1_IP-MS_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
5186223-885	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.6333
LRRC59	Pathway Commons Protein-Protein Interactions	1.0	null
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.4355
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.32221
Translation	Reactome Pathways 2024	1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsomedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.839786
EP300_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7251_KD_CYFIP2_SRP267677	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.35154
496100485_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.31887
BRD-K47874568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09969
nuclear lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
6537_POLR1D_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.663432
salsolidin-4226	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_10079_KD_HNRNPC_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.48777
BRD-K35828963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80659
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
5-R-Rivaroxaban	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
Sarcoma_SARC_TCGA-JV-A5VF-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3380-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8188_KD_HNRNPC_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.6201
USF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPJH-0326-SM-3GADU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936441
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83998
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12000322-41419_2025_7601_MOESM11_ESM.xlsx-H3122_AR_Nonsynonymous_mutation-Hugo_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Skin	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.959729
Ovarian Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.30994
Perturb_2124_KD_NFKBIA_SRP285793	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.53456
4684_LSG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.965795
XRCC5	Pathway Commons Protein-Protein Interactions	1.0	null
7499_RPS11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51835
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16332
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.904802
Perturb_511_OE_ACE2_SRP278541	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.64116
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.2198
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933039
PNO1	Pathway Commons Protein-Protein Interactions	1.0	null
EIF3F	Pathway Commons Protein-Protein Interactions	1.0	null
ATF3	ChEA Transcription Factor Targets	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55311
tanespimycin-2678	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LEMD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35496
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
acetylsalicylic acid-2664	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
duodenum	HPA Tissue Protein Expression Profiles	1.0	1.24651
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.02959
sulfadimidine-3765	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_7629_KD_UPF1_SRP129007	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.49133
BRD-K53257131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60098
GATA1_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX5	Pathway Commons Protein-Protein Interactions	1.0	null
Nervous System Malformations	CTD Gene-Disease Associations	1.0	1.14336
ZC3HAV1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31203
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.8644
GTEX-P4QT-0126-SM-2I3FL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831143
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842517
Small ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PRPF8	Pathway Commons Protein-Protein Interactions	1.0	null
NZM7	DepMap CRISPR Gene Dependency	1.0	2.52397
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZEB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrial inner membrane	GO Cellular Component Annotations 2025	1.0	null
SW626	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.84759
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61433
basal nucleus of meynert, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17378
MSH2	Pathway Commons Protein-Protein Interactions	1.0	null
DB	CCLE Cell Line Gene Expression Profiles	1.0	1.64416
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39668
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46072
K562	BioGPS Cell Line Gene Expression Profiles	1.0	0.922489
Perturb_8141_KD_MAGOH_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.771
Perturb_9821_KD_MYB_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.65759
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03507
RPS18	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JD-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.454274
esculin-3390	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.97992
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-7490-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5651844-41467_2017_1173_MOESM10_ESM.xlsx-ZZZ3_occupied_genes-Supplementary_Data_7_ZZZ3_occupied_genes_and_overlaps_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YARS2	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_3912_KD_Y14_SRP118481	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.71
Perturb_8276_KD_UPF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.12561
HNRNPH1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03645
BRD-K42814713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39188
Prelimbic area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01434
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02954
18787207-TableS2	GeneSigDB Published Gene Signatures	1.0	null
9396_TTF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.690201
10-methoxyharmalan-5455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.503806
alpha-ergocryptine-2572	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K21784579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04748
Perturb_8781_KO_DNMT3A/DNMT3B_SRP186642	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.53048
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13862
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K50815029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04244
PMC10214295-mmc4.xlsx-B_-_Beta_Cell_ZBTB16_targets-Gene_Name_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
GATA1_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08336
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2BK12ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Primary somatosensory area, upper limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67621
Rivastigmine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6271
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
5702_NLE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.942292
BRD-K71537579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35243
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
496100294_HIP_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01324
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.52633
Perturb_12951_KD_ALKBH5_SRP247667	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.12402
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.866448
H3K36me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36383
BRD-K36474885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74232
Ventral posteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11921
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.93849
BRD-K55144248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14233
H2BK12ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0691
POLR2H	Pathway Commons Protein-Protein Interactions	1.0	null
964_C12ORF45_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578133
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957564
Rhodanine derivative38	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
PHF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0977
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SEPT7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K03713632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64575
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.91963
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
metergoline-6744	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZBTB33_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-3.22204
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5661_KO_ID2_SRP336141	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.4587
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.6794
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.996295
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.90365
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
intracellular part	GO Cellular Component Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M4-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9852_KD_LUC7L_ERP124746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
parathyroid gland	HPA Tissue Protein Expression Profiles	1.0	1.24651
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
1470_CEBPZ_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.02024
GTEX-WFG7-1126-SM-4LMK3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95356
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26094217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35075
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
7461_RPL34_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.44862
Perturb_10023_KD_RCC2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.0434
MOLT4	CCLE Cell Line Gene Expression Profiles	1.0	2.0684
RFX5	ENCODE Transcription Factor Targets	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25479
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CEBPD_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.939717
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9858_KO_MYB_SRP192629	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.28306
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.945626
GTEX-OHPM-1426-SM-3TW8Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8669
osteoclasts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.0315
PCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
Submedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.93519
2105_DDX18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.712088
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17328
BRD-K15924535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59638
1651_CLEC2L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.659356
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL17	Pathway Commons Protein-Protein Interactions	1.0	null
MK 886	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.927128
Field CA3, stratum lucidum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22083
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.840749
orbital frontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.853286
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2898
TAL1	ENCODE Transcription Factor Targets	1.0	null
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
Crus 2, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56746
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02387
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_FIGLA-Unnamed_1_FIGLA	Rummagene Transcription Factor Associations 2026	1.0	null
roxithromycin-4192	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_7624_KD_ZFR_SRP107875	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.50468
piribedil-5434	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63489
translation	GO Biological Process Annotations 2023	1.0	null
Perturb_15101_KD_PDHA1_SRP385600	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.17515
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15571
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55D-1826-SM-48FEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04385
GW842166X	DeepCoverMOA Drug Mechanisms of Action	1.0	0.45
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.53813
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7443_RPL18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24478
SNU719	CCLE Cell Line Gene Expression Profiles	-1.0	-1.84183
Perturb_8238_KD_RBM25_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.93143
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1801
Perturb_7459_KD_ICE1_SRP120604	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE239578_2_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.961859
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.84518
Crus 1, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09656
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEAD4_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12000322-41419_2025_7601_MOESM11_ESM.xlsx-H3122_AR_Nonsynonymous_mutation-Gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RCC-ER	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.0088
H3K4me1_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TRIM29	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A622-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PATU8902	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36464
Siponimod	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
Brain Lower Grade Glioma_LGG_TCGA-HT-7471-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-80-CK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207946
GTEX-Q2AH-0126-SM-48U2B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0263
BRD-K34209560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85903
organelle inner membrane	GO Cellular Component Annotations 2015	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.853235
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal egg cylinder morphology	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2258
BRD-K49995660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06891
anterior (rostral) cingulate (medial prefrontal) cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51706
intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Prostate adenocarcinoma_PRAD_TCGA-J4-A67R-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX3X	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K54650634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49356
CDX2-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC11814291-41698_2025_830_MOESM1_ESM.pdf-4-KLF14_KLF14	Rummagene Transcription Factor Associations 2026	1.0	null
intermediate stratum of ITTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0324
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6921
SW1783_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	4.0328
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.19287
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.0319
BRD-K79152256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97954
AF4-26711339-SEM-HUMAN-BLOOD-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.840923
rRNA binding	GO Molecular Function Annotations 2025	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SBC-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.29084
COLO684	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62364
PF-00875133-00-5967	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prestwick-857-3016	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92446632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42285
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23632
PMC3807112-srep03041-s6.xls-GABPA-Gene_Symbol_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11941
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02159
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04414
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19842
quinisocaine-4791	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_9815_KD_UTX_SRP062773	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.02258
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8237_KD_QKI_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.3378
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.91504
7482_RPLP0_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519688
CREB1	ENCODE Transcription Factor Targets	1.0	null
CEBPB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23579
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2H1-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211929
Perturb_8203_KD_HLTF_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.31284
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4154-01A-01R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966083
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12697907-ADVS-12-e07451-s002.xlsx-ST4E_MR-pancanQTL-Table_S4E_The_Mendelian_randomization_estimates_using_eQTL_data_from_PancanQTL_database_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.959365
5737_NOL8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.790046
cefepime-5761	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
QARS	Pathway Commons Protein-Protein Interactions	1.0	null
Ectorhinal area/Layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12595
terbutaline-3202	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.495593
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A763-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
9618_URB2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.644935
Perturb_11352_KD_PRMT5_SRP134236	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.43037
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.88085
GSE171724_4_v_6_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_9861_KO_MYB_SRP192629	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.96676
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.361575
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30704
GSE216043_11_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
superficial stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32741
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.05211
CRCGN014_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07705
K562_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180087
NFE2	ENCODE Transcription Factor Targets	1.0	null
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10317744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16193
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13542
HOXC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10981
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.62721
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.28025
5909_NVL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.719387
7469_RPL38_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.17442
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIST1H1D	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-3783-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-V955-0126-SM-4JBH5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927604
lateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.949439
HNRNPA2B1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_10130_KD_GATA1_SRP090317	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.3379
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05875
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.28349
PMC3419980-leu201249x6.xls-RUNX1-DHS-1000bp-Unnamed_0_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K79me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_17691_KD_MDMX_SRP393452	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.96882
KDM5B	ENCODE Transcription Factor Targets	1.0	null
PMC7801680-41598_2020_79740_MOESM9_ESM.xlsx-STAT3_target_genes_in_N1-GOPC_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19873
Perturb_11380_KD_GATA2_SRP178865	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.76166
7487_RPP14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.676844
mantle zone of r1BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10627
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7333_KO_SF3A1_SRP273617	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.46793
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gliquidone-6004	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23492
metitepine-3231	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.39605
E2F4_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8826_TEX10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.961429
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-PAX6_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
structural constituent of ribosome	GO Molecular Function Annotations 2015	1.0	null
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RUSQ-0826-SM-47JWW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04506
MBD4	ENCODE Transcription Factor Targets	1.0	null
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pralidoxim	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17047
Perturb_10004_KD_KRR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.7
TOLEDO	CCLE Cell Line Gene Expression Profiles	1.0	1.94585
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A766-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13927_OE_ESRRG_SRP363188	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.48292
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE102505_4_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JHH5	DepMap CRISPR Gene Dependency	1.0	2.0067
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LRPPRC	Pathway Commons Protein-Protein Interactions	1.0	null
Paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.60018
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3455-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9691391-7945884.f3.pdf-196-ENSG00000213988_ZNF90	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2682_KD_YAP1_SRP181909	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.93613
CNOT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23427
monobenzone-3391	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41212
CRCGN014_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96345
Purkinje cell layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04195
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
I3C	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
mitochondrial matrix	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4259_KD|OE_HOXB13|MEIS1_SRP201342	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.30843
intermediate stratum of r3BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24812
molindone-4199	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.800809
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5447
HCV_8week-No IFN-a_None_GSE37715	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.75531
7458_RPL30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.615178
small ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
IGF1R_knockout_151_GSE32936	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.98282
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23099
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.957965
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.10709
TMPO	Pathway Commons Protein-Protein Interactions	1.0	null
H4K91ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Basolateral amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06978
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12466
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01748
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4762-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
FGFRL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.024
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.852477
RPL27A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K92791036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41938
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CCDC88C	Pathway Commons Protein-Protein Interactions	1.0	null
LIG4	Pathway Commons Protein-Protein Interactions	1.0	null
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.861929
RUNX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2378
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48021
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
arcuate nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0573
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6462
hydroquinine-2767	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285707
SARS-CoV_72Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.36347
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEF2A	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.873595
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85689
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911625
hsa-miR-3659	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CCNC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40813
Anteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25626
SNAI1_01_69	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.5861
GTEX-U4B1-0126-SM-4DXSN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900977
medial trapezoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42286
sulfasalazine-5446	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_13958_KO_YAP1_SRP194022	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.02017
7522_RPS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.628584
CREB1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7444_RPL19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.58604
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89031
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944077
MOGS	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78P-01A-12R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.963955
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238371
E2F4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA4 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.45886
8660_TAF1D_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.922617
7500_RPS12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.675889
CAL27	DepMap CRISPR Gene Dependency	1.0	2.65123
Perturb_7503_KD_SUDS3_SRP194754	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.55604
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA42-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4271	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Posterior parietal association areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43931
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
absent head fold	MGI Mouse Phenotype Associations 2023	1.0	null
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15221_KD_RACK1_SRP330756	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.67537
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.827588
Perturb_11538_KD_YEATS2_SRP094447	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.73084
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875321
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63144
Perturb_4539_KD_A2l_SRP126769	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.16132
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.97727
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0753
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.6993
Perturb_10400_KD_ASH2L_SRP277215	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.25187
sulfamethizole-6099	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324426
BRD-K82827604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16983
MTHFD1	Pathway Commons Protein-Protein Interactions	1.0	null
RBM19	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K60719499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.107
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04749
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrial translation	GO Biological Process Annotations 2015	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
AD-51-FB60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.665634
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82112239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32032
Perturb_2324_KD_SF3A1_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.54252
LY-294002-2676	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02189
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7134
CREB1-15753290-HEK293T-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
trifluoperazine-5442	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TFE3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4937
Ventral anterior-lateral complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66005
Field CA3, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22536
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56935
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6441-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRPF19	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4632-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIX5	ENCODE Transcription Factor Targets	1.0	null
7503_RPS15A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504583
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.844419
FOXP3	ChEA Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.426
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.60184
ZBTB33_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PPP1R13L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35539
ATF3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5068-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251381
BRD-K23547378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07022
GTEX-QDT8-1026-SM-43V6X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868531
Primary somatosensory area, upper limb, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23729
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36204977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05869
SRSF2	Pathway Commons Protein-Protein Interactions	1.0	null
CREB3L4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1573
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.90029
BRD-K99681648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08805
TEAD4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DHX15	Pathway Commons Protein-Protein Interactions	1.0	null
M040416	DepMap CRISPR Gene Dependency	1.0	2.79591
anterior (rostral) cingulate (medial prefrontal) cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12603
H3K36me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K62547690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26271
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.63856
Primary somatosensory area, upper limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27062
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86929
mitochondrial part	GO Cellular Component Annotations 2015	1.0	null
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01733
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.954904
Skin Cutaneous Melanoma_SKCM_TCGA-RP-A6K9-06A-41R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14879_KO_H14_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.55698
RFC2	Pathway Commons Protein-Protein Interactions	1.0	null
XRN2	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
MRM1	Pathway Commons Protein-Protein Interactions	1.0	null
10722_ZSCAN2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.7695
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96440230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42766
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.860097
GTEX-T6MN-0826-SM-32PM4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946782
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53411
mitochondrial gene expression	GO Biological Process Annotations 2023	1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.56418
GTEX-UJMC-0226-SM-4IHLH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74442
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13957
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
874_BOP1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.987323
BRD-K82105033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18815
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.128
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.882792
SP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.887346
Cortical amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15335
CREB1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL7A	Pathway Commons Protein-Protein Interactions	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
etoposide_homo sapiens_gpl10558_gse33990	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0525
heptaminol-6015	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATF2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HELQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84454
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.593258
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.948561
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.1328
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20497425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04983
laterostriatal stripe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37121
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MRPS31	Pathway Commons Protein-Protein Interactions	1.0	null
JK1	CCLE Cell Line Gene Expression Profiles	1.0	2.90412
estradiol-5238	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23K-01A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.18192
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
5739_NOLC1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506999
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TUFM	Pathway Commons Protein-Protein Interactions	1.0	null
NRF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-1026-SM-33HBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11057
inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.80788
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885075
Perturb_9854_KD_LUC7L3_ERP124746	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.7564
Nobox	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.9474
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.50878
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.6608
tonsil	HPA Tissue Gene Expression Profiles	1.0	0.921115
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRP9	Pathway Commons Protein-Protein Interactions	1.0	null
translation	GO Biological Process Annotations 2015	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8259
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7181_OE_MAGEA11_SRP216417	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29994
PML_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K41355409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29556
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
decreased circulating creatinine level	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-A61778798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20208
Perturb_2313_KD_LUC7L2_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.36023
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01159
Perturb_12140_KD_PRPF8_SRP093921	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2113_DDX24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00156
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316937
Perturb_5297_KD_INSR_SRP045438	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.38439
BRD-K25649458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80035
ATF3_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
S0-EE-WJKI_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227472
protein complex subunit organization	GO Biological Process Annotations 2015	1.0	null
BRD-A31916785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08623
Mavorixafor	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
PNPLA6	Pathway Commons Protein-Protein Interactions	1.0	null
P3HR1	CCLE Cell Line Gene Expression Profiles	1.0	1.52423
naloxone-4645	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7203_KD_DHX9_SRP080966	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.78058
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
failure to gastrulate	MGI Mouse Phenotype Associations 2023	1.0	null
Utricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.018
HIST1H1B	Pathway Commons Protein-Protein Interactions	1.0	null
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.940726
H3K79me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RSL1D1	Pathway Commons Protein-Protein Interactions	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF3D	Pathway Commons Protein-Protein Interactions	1.0	null
isocorydine-4505	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETV2::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1445
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-2126-SM-3MJGK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850616
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15119
BRD-K30661365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40917
GSE195503_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842517
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08244
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.3705
EHHADH	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3229
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6755
10702_ZNHIT6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.527879
Vagina	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.952373
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_17802_KO_ZNF675_SRP305529	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.45278
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEC1	DepMap CRISPR Gene Dependency	1.0	2.05329
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.73927
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE226983_2_v_0_ddx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TET1-21490601-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
496100519_HIP_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.09526
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K36me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SUCS-1926-SM-32PM3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87155
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RCOR3-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K86086888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21556
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6632
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SF3A3	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-73-7499-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POU5F1-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
5737_NOL8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.656933
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53902
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Basolateral amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02183
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9534
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.00766
cloperastine-4732	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.4271
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157105
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66259
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.597679
PMC3807112-srep03041-s6.xls-ELK4-Gene_Symbol_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
salbutamol-2306	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SUM185PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.801343
GTEX-RN64-1226-SM-2TC6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875199
H3K4me1_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2H0-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPP38	Pathway Commons Protein-Protein Interactions	1.0	null
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBM39	Pathway Commons Protein-Protein Interactions	1.0	null
YTHDF3	Pathway Commons Protein-Protein Interactions	1.0	null
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
RPL19	Pathway Commons Protein-Protein Interactions	1.0	null
2456_EBNA1BP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.906776
CHTF18	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K96149826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27675
IFI16	Pathway Commons Protein-Protein Interactions	1.0	null
medial geniculate nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885676
3594_GTPBP4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.681803
GTEX-PLZ5-0326-SM-3P614	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30935
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922802
H4K20me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Central linear nucleus raphe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24945
AUH	Pathway Commons Protein-Protein Interactions	1.0	null
K029AX	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4015
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
caco2	HPA Cell Line Gene Expression Profiles	1.0	1.15958
Perturb_2330_KD_SNRPB_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.01197
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A5VM-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7323_KO_DCP2_SRP070463	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.38735
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
7426_RPF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.612264
GTEX-NFK9-1726-SM-3TW8P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39231
BRD-K24549321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44194
GSE131660_2_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.56558
Perturb_2681_KD_TEAD4_SRP181909	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.17921
SYNCRIP	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_14576_KO_NQO1_SRP217327	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.49033
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.41314
2124_DDX47_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.930609
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46454
5707_NMD3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.998929
GSE124375_13_v_12_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2986-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE196505,GSE196507_1_v_2_kdm2b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_15044_KD_PTBP1_SRP124244	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K53797069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02377
Perturb_15491_KO_BCOR_SRP168753	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.30907
BARX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12216
clopidol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19486
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39863565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61046
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-REY6-2126-SM-48FD9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06777
azapropazone-6522	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54637
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5678-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 4 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24945
RPL32	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10131_KD_GATA1_SRP090317	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.70132
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.71911
GTEX-PLZ6-0926-SM-3P5ZQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964164
GTEX-XQ3S-0926-SM-4BOPI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12417
H3K36me3_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
absent primitive node	MGI Mouse Phenotype Associations 2023	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
7512_RPS23_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.735355
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.915571
prostate	GTEx Tissue Gene Expression Profiles	-1.0	-0.875145
GSE183271_2_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4062
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925874
KDM5A	ChEA Transcription Factor Targets	1.0	null
ELK1	JASPAR Predicted Transcription Factor Targets	1.0	null
DAP3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TMMY-1126-SM-4DXSX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.294
6887_PSMG4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.515847
rectum	HPA Tissue Protein Expression Profiles	1.0	1.24651
8855_TFPT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.06896
Perturb_17418_KO_Myd88_ERP115704	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.5777
Perturb_2338_KD_MUC1C_SRP300048	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.3979
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03318
SEPT9	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K64860451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22343
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
STAT5A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GPR27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66196
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06645
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
USF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2486
ZNF281	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17117
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NADSYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35052
GTEX-PLZ6-0226-SM-3P61I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87705
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17294
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K35128023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58704
2376_DROSHA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.67575
ATP5F1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02017
betahistine-4956	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Fog2_KO_GDS3659_152_mouse_adult heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4213
BRD-K25709301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.52688
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00057
Perturb_535_KD_KDM1a_SRP106818	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Posterior parietal association areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11747
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.865195
CTCF_cardiac muscle cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
benzocaine-4808	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K11003742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18483
Kidney Chromophobe_KICH_TCGA-KN-8432-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Field CA2, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06866
Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A64V-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_923_KD_KRT18_SRP283920	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.06535
CHD7	ENCODE Transcription Factor Targets	1.0	null
Perturb_14561_KD_UBE2C_SRP221206	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.57709
fulvestrant-5969	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-1676-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.9486
BRD-K74363294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25034
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977014
5211181-834	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IRF4_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-2326-SM-3DB7W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827586
10569_ZNF705B_ENST00000443676.1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.597923
GSE139540_0_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
decamethonium bromide-4174	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-X5EB-0526-SM-46MVP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828539
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.42192
lovastatin-2854	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urapidil-6455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22957
Organellar small ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL-120	GDSC Cell Line Gene Expression Profiles	-1.0	-1.7904
sulfamethizole-2536	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_11525_KD_SNW1_SRP092641	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.17352
1470_CEBPZ_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.629113
BRD-A29578214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43581
TAF7_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTNND1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ATF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
GATA1_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3573_KD_JAB1_SRP222371	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
septopallidal core nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19406
MAX	JASPAR Predicted Transcription Factor Targets	1.0	null
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U2AF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.646
H3K4me1_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04244
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7968
DHX16	Pathway Commons Protein-Protein Interactions	1.0	null
SUDHL5	DepMap CRISPR Gene Dependency	1.0	2.88476
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03119
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21566
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DBR1	Pathway Commons Protein-Protein Interactions	1.0	null
CORL311	DepMap CRISPR Gene Dependency	1.0	2.41886
BRD-K48710089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02444
5733_NOL11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.649184
Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9924_KD_RBM22_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.93631
GSE168676_0_v_1_dach1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291463
GTEx Heart 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-9.98496
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.62526
Perturb_365_KO_PTPN2_SRP108032	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.944
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100487_HIP_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23335
REST_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A7EU-01A-22R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
valdecoxib-6378	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posterior tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67695
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.03406
hsa-miR-4645-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
striatum_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.57676
velnacrine-2430	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBMX	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN014_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.78099
KURAMOCHI	CCLE Cell Line Gene Expression Profiles	-1.0	-2.75001
pivampicillin-3506	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_6836_KO_METTL3_SRP193002	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.8968
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Eltrombopag	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
lateral amygdaloid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09985
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.698339
ventral lateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.1498
AZ20	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.0
BRD-K31273080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09656
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.1677
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.79664
Perturb_8670_KO_SETD2_SRP291759	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.12515
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854557
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854247
PES1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_14873_KO_H11_ERP118037	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.83286
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.00968
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.37187
2129_DDX54_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09164
MZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.58949
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.39846
t30-blood-rna_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.34331
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2201
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.58285
POLR2A_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CPSF2	Pathway Commons Protein-Protein Interactions	1.0	null
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
BF-79-GG96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22856
NCIH1373	CCLE Cell Line Gene CNV Profiles	1.0	2.06181
9841_WDR75_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.733677
SRF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE62843,GSE64370_0_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7499_RPS11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.581936
GTEX-TKQ1-0326-SM-4DXSM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16133
874_BOP1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.97284
PPARG-20887899-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28217
medrysone-4727	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9814_KD_TAL1_SRP062773	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.7393
isthmic liminal reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27675
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-0.945662
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J2-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K00804254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46973
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2195
Perturb_289_KO_PHF8_SRP399627	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.0023
H3K27ac_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
308_ANAPC4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.30585
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855921
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.944292
memantine-4017	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF416	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8957
ribosomal subunit	GO Cellular Component Annotations 2015	1.0	null
BRD-K94962942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00113
SF3B2	Pathway Commons Protein-Protein Interactions	1.0	null
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.972672
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243551
Perturb_12927_KO_CLPB_SRP181053	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.11028
all	GWASdb SNP-Phenotype Associations	1.0	0.02889
benzylpenicillin-3577	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.44168
Perturb_13603_KD_KLF4_SRP221596	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63U-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF3L	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_7547_KO_CNOT1_SRP282906	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.91017
9682_UTP15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.876332
submedius thalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62418
nifenazone-6016	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PKP3	Pathway Commons Protein-Protein Interactions	1.0	null
betulinic acid-3281	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ATF1	ENCODE Transcription Factor Targets	1.0	null
GSE216043_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3952
BRD-K46839342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23106
2129_DDX54_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.645544
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75768
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.905681
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01181
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.52866
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5277
33_ABCF1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.755195
SUPT20H_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9556
TCF12	ENCODE Transcription Factor Targets	1.0	null
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12260418-pnas.2425984122.sd02.xlsx-TEAD1_6fraction_test_result-Unnamed_3_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
EIF3G	Pathway Commons Protein-Protein Interactions	1.0	null
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRIM25	Pathway Commons Protein-Protein Interactions	1.0	null
10231_ZNF236_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.856497
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
2113_DDX24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.86013
NCIH28	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40099
corbadrine-5854	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_266_KO_ADIRFAS786_SRP366780	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.82963
Perturb_32_OE_ERG/MYC_SRP069177	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.809
SSBP1	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.01549
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSPA8	Pathway Commons Protein-Protein Interactions	1.0	null
7471_RPL39_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.608746
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RMDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07737
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior intralaminar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94784
BRD-A64153357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27668
CRCGN008_HEPG2_24H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34045
7437_RPL13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.571846
BRD-K05329107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22672
Perturb_9923_KD_PTBP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
7478_RPL7L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.679884
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24109
MTDH	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3395_GLIS1_ENST00000312233.2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574854
primary visual cortex (striate cortex, area V1/17)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.937032
khellin-4987	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NUDT21	Pathway Commons Protein-Protein Interactions	1.0	null
PLX-4720	DeepCoverMOA Drug Mechanisms of Action	1.0	0.88
7432_RPL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05119
Acute Myeloid Leukemia_LAML_TCGA-AB-2814-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
pinacidil-5456	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.18014
pontine nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30985
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
epididymis	HPA Tissue Protein Expression Profiles	-1.0	-0.945662
Visual pathway disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE117643_1_v_0_irx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BHLHE40_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFEB	ChEA Transcription Factor Targets	1.0	null
Perturb_2719_KD_BRD_SRP115100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.20457
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17417
ribavirin-7316	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q7-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7459_RPL31_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.65961
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIPK2_defectivemutant_17_GDS1793	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.54539
BRD-K44421266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25103
Perturb_96_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.51268
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K31721388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29145
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.893239
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DE-81-OY65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278445
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
lateral septal nucleus, intermediate part, periventricular	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.13748
BRD-K83436911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11123
PRPF4	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_2729_KD_BCL11A_SRP258724	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.22397
PECAPJ34CLONEC12	DepMap CRISPR Gene Dependency	1.0	2.24689
RELA_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WY7C-0526-SM-3NB3D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19339
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K54637865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28095
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
C-75-6399	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MDA-MB-468	GDSC Cell Line Gene Expression Profiles	-1.0	-1.91131
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.80197
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WTAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06569
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.918562
GTEX-QLQW-0226-SM-447BJ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.38835
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07757
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07562
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8001-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB33_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
flupentixol-2643	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE213746_0_v_1_kdm5b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLDIP3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17197
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.955706
CHLA10	DepMap CRISPR Gene Dependency	1.0	2.13351
2580_EIF6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.40626
MCM3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q734-0126-SM-48U1E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21309
H4C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35776
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899485
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39X-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VENTX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.98
Lung adenocarcinoma_LUAD_TCGA-49-4490-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01614
U343	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7952
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6K1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
acetylsalicylic acid-5201	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3677_HEATR1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.96748
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5635
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72998
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-8693-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9me3_Fetal Heart	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
gelsemine-2817	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
USP39	Pathway Commons Protein-Protein Interactions	1.0	null
LY411575	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
subgranular zone of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.8891
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KNS60	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62218
GTEX-UPJH-0926-SM-4IHKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85651
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.82417
cefoxitin-2735	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
embryoday6.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.839982
RBM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02571
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5966-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_9668_Mut_NR1H4_SRP115904	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.7744
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.51622
intermediate stratum of r5Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39219
LSM6	Pathway Commons Protein-Protein Interactions	1.0	null
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305654
SRSF4	Pathway Commons Protein-Protein Interactions	1.0	null
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.8283
BRD-K99077411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40131
SUCLG1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_2327_KD_SF3B3_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.15269
RAD21_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KHDRBS1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PTPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19884
r1 part of dorsal raphe nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60525
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10905
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3413
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.121464
BRD-K50146767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36666
doxycycline-2737	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32468
Roxatidine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.46
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842517
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49636
translational elongation	GO Biological Process Annotations 2015	1.0	null
KE39	CCLE Cell Line Gene Expression Profiles	1.0	1.45477
9482_UBA52_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.90662
7566_RRP7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.553224
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
KDM4A	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-H9-A6BY-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.38681
kinetin-6813	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MJ-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.995171
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1987
Perturb_5630_KD_EWSFLI1_SRP340258	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.89704
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE184884_7_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
USF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_9063_KD_NANOG_SRP100928	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.98663
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6QY-01A-12R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5735_NOL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.967181
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11835
7479_RPL7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.34108
NCI-H1836	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.55442
USF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 1 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.325
SNB19	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.70206
CREB1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ILF2	Pathway Commons Protein-Protein Interactions	1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.52512
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.58045
4470_KRI1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.716289
(4-Chlorobenzyl)pyridine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
Medial septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67695
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20319
9684_UTP20_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526397
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A6SH-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5731_NOC4L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.551874
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4666-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1272
Ventral tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.03189
Bach1::Mafk	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.3509
NCL	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4272	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K74677971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63486
icSARS CoV_36Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.68483
RPS13	Pathway Commons Protein-Protein Interactions	1.0	null
GSE222574_0_v_2_lmna_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.95196
PLOD3	Pathway Commons Protein-Protein Interactions	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0956
NCIH146	CCLE Cell Line Gene CNV Profiles	-1.0	-2.62268
H3K36me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF3K	Pathway Commons Protein-Protein Interactions	1.0	null
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.842517
TC-71	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.29694
SYMPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75388
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3607-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pc3	HPA Cell Line Gene Expression Profiles	-1.0	-0.922714
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.13069
PMC4486168-pone.0131961.s006.xlsx-Sheet1-ARID3B_Upregulated_Genes_ARID3B	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.787892
LSM2	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VG-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07199
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTFR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29639
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4706
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-1426-SM-3MJHC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23528
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IST-SL2	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.74789
GSE188570,GSE188571_3_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
outer CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0209
Perturb_3911_KD_SOX9_SRP118481	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.80559
Perturb_3517_KD_RBM8A_ERP130710	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.7847
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19581
7439_RPL15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.98108
GTEX-SUCS-0526-SM-4DM56	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22847
DMD_Deficiency_GDS2996_613_mouse_Cardiac muscles from 8-week (mdx animals)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-A31962514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6939
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47701
PMC9541747-AGE-53-680-s003.xlsx-TableS6-Table_S6_Genes_with_missense_mutations_in_Yaroslavl_cattle_MAF_0_1_and_FST_0_4_in_the_1000_Bull_Genomes_Run_9_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
principal sensory nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.846127
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.695518
hippocampus (hippocampal formation)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.991858
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854557
CSTF3	Pathway Commons Protein-Protein Interactions	1.0	null
basomedial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.45359
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.58352
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16265
Perturb_9823_KD_TAL1_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.33386
Benzbromarone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-2.19
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.825749
MRPS18B	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.057
valproic acid-5219	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.16977
GTEX-RTLS-0226-SM-2TF5E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879597
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137144_5_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10044_KD_EFTUD2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-18.5686
AG-013608-5904	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPS8	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K92806245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35311
KM12	CCLE Cell Line Gene Expression Profiles	1.0	1.51534
GSE155567_3_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
7462_RPL35A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10476
oval paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.62329
mantle zone of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0469
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10103
10040_ZCCHC9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552821
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824902
H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
fenoterol-5432	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J2-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_8048_KD_METTl14_SRP167173	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.02344
Perturb_95_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.6997
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.703639
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1502
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMARCC1	Pathway Commons Protein-Protein Interactions	1.0	null
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
embryonic lethality prior to organogenesis	MGI Mouse Phenotype Associations 2023	1.0	null
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02516
MRPS9	Pathway Commons Protein-Protein Interactions	1.0	null
r10 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28266
GSE239578_0_v_6_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SPATS2L	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8207_KD_RAVER1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.65483
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.57345
PMC3807112-srep03041-s6.xls-E2F1-Gene_Symbol_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Secondary motor area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34755
Perturb_12362_KD_SNRPB_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.19353
UACC812	CCLE Cell Line Gene Expression Profiles	-1.0	-2.71595
hsa-miR-379	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
inferior frontal gyrus, opercular part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.904275
EIF4G1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-199a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28223
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.97724
BRD-K64317863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27475
KAT2A	ENCODE Transcription Factor Targets	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24832
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946448
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
retrorsine-4946	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20114
SW1573	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35396
personality disorder	GWASdb SNP-Disease Associations	1.0	0.908515
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63555
Perturb_10016_KD_HNRNPF_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.7824
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.33149
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.904802
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.88745
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
celecoxib-922	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MUTZ8	DepMap CRISPR Gene Dependency	1.0	2.05579
PTBP3	Pathway Commons Protein-Protein Interactions	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_astrocyte of the cerebellum_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU3F2	ChEA Transcription Factor Targets	1.0	null
MRPS28	Pathway Commons Protein-Protein Interactions	1.0	null
RBPJ-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Infertility, Male	CTD Gene-Disease Associations	1.0	1.14438
CTCF_lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE216043_10_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3157
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75815721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35466
GSE134986_2_v_8_oma1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ATF3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3423
TCS PIM-1 1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.21
BRD-K60166659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46709
FLI1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX21	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
Perturb_10250_KO_WT1_ERP126063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.91629
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.3203
SKIV2L2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.434633
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EMG1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_8136_KD_G3BP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.64426
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2015	1.0	null
H3K9ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
U2AF2	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_5563_KO_KDM4C_SRP375293	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.82546
Perturb_12314_KO_AGO1_SRP136692	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
ZBTB33_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552493
CRCGN016_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11583
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A685-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06856
Perturb_17613_KI_FOXP2_SRP225889	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
DAZAP1	Pathway Commons Protein-Protein Interactions	1.0	null
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0229
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Quetiapine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942259
pyrvinium-5439	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8577
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36885
SNG-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4733
Perturb_2823_KD_MEG3_SRP238079	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.088
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HO-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
WSUDLCL2	CCLE Cell Line Gene Expression Profiles	1.0	1.86367
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.75768
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05404
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15366
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9857_KO_MYB_SRP192629	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.10418
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340992
7453_RPL26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.10684
GTEX-W5WG-1626-SM-4LMKG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921506
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.00215
mitochondrial inner membrane	GO Cellular Component Annotations 2015	1.0	null
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ventral reuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21904
THAP1	ENCODE Transcription Factor Targets	1.0	null
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
wortmannin-4467	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SARS-CoV MA15_Day4_None_GSE49263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.76412
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18804
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9415
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.945941
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.565148
Lung squamous cell carcinoma_LUSC_TCGA-18-3416-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6845_KO_ABCE1_SRP244437	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.46924
BRD-K41206520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33858
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_13380_KO_CTIP2_SRP150394	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.99032
CRCGN011_HEPG2_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1479
NPM1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_11382_KD_NKX25_SRP152523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.51667
H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZNF512	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54034
IARS	Pathway Commons Protein-Protein Interactions	1.0	null
EP300_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2635
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
r2 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45712
PMC9084694-RMB2-21-e12464-s005.xlsx-GV_MI_MII_GV-up-GeneName_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.81646
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5299
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A495-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HCT-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.861469
H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE127970_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATF3_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AIMP2	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MP-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HNRNPL	Pathway Commons Protein-Protein Interactions	1.0	null
NOA1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4593_LIN52_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.617007
CTCF_epithelial cell of esophagus_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7018-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_7460_KD_UPF3B_SRP120604	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.21349
hyoscyamine-5099	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.36292
Perturb_4905_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.22364
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69201
BRD-K06279388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2048
SKLU1	CCLE Cell Line Gene Expression Profiles	1.0	1.43952
Lung squamous cell carcinoma_LUSC_TCGA-22-5481-01A-31R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism biosynthetic process	GO Biological Process Annotations 2015	1.0	null
RTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17812
microcellular tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66387
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3QD-01A-32R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30522
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK4	ENCODE Transcription Factor Targets	1.0	null
CAPAN2	CCLE Cell Line Gene CNV Profiles	1.0	1.34063
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07204
GVINP1	Pathway Commons Protein-Protein Interactions	1.0	null
ABCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81154
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14737_OE_ADAR1_SRP250165	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.51006
9816_WDR36_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.576635
Hs-578-T	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.66993
OPM2	CCLE Cell Line Gene CNV Profiles	1.0	1.35384
9482_UBA52_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.753532
TEK_knockdown_122_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.92277
red nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16085
BRD-K48691513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34213
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.29233
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.89634
Hermansky-Pudlak syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
HCFC1	ENCODE Transcription Factor Targets	1.0	null
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9822_KD_RUNX1_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Metabolism of proteins	Reactome Pathways 2024	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01268
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K29649571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01574
Perturb_2985_KO_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.22618
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JW-0326-SM-4DM6J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974156
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K36me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RELA_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77228
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60443
dorsal lateral geniculate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.64154
USF1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
epitiostanol-4788	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1912
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125007,GSE125008_6_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.324002
mantle zone of SeStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08367
EP300_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0726-SM-3DB8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08537
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.99471
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Perturb_4375_KD_CREBBP_SRP072506	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.737
7566_RRP7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.616589
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K05057860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40593
TRMT6	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_9817_KD_E2A_SRP103740	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.6914
GSE130437_2_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bucladesine-2741	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TE15	CCLE Cell Line Gene CNV Profiles	1.0	1.5222
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	1.0	1.37339
Perturb_3970_Mut_BRAF_SRP258593	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.75218
KH7	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.01
H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
XRCC6	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23601
BRD-K14392329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16541
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LSM3	Pathway Commons Protein-Protein Interactions	1.0	null
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.557
Ribosomal protein S18, conserved site	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5397
BRD-K74705119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68279
2545_EIF3B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.674824
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.662664
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37531
PEER	CCLE Cell Line Gene Expression Profiles	1.0	1.6647
2622_EMG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.656482
2105_DDX18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.806327
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04458
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78K-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87969
translational termination	GO Biological Process Annotations 2015	1.0	null
chemdependency	GAD High Level Gene-Disease Associations	1.0	0.293278
Mitochondrial iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.992
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K35188988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70372
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382852
telenzepine-2388	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE153871_0_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
co-dergocrine mesilate-4071	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999849
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.89209
Perturb_3540_KO_ZNF410_SRP304786	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.40231
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U4B1-1126-SM-4DXV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32653
PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
7491_RPP30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.547726
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Mitochondrial translation initiation	Reactome Pathways 2014	1.0	null
KM12	BioGPS Cell Line Gene Expression Profiles	1.0	0.82968
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS11	CCLE Cell Line Gene CNV Profiles	1.0	1.39556
BRD-K29138092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41731
RUNX2	ChEA Transcription Factor Targets	1.0	null
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
dimenhydrinate-5450	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFIC_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_10129_KD_eHDAC6_SRP090317	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.2256
lateral (parvicellular) part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12818
4108_IMP4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.628892
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01114
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.810262
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0452
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K26435104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40395
Perturb_13896_KO_TLR3/MYD88_SRP332441	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.07088
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238016
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16821
RPL24	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QEG5-1126-SM-33HC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827258
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRPF31	Pathway Commons Protein-Protein Interactions	1.0	null
H1FX	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K21866464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04565
BRD-K86453556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20602
Perturb_7590_KD_GEMIN5_SRP368027	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.91079
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5886-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.84731
GSE133683_1_v_5_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3	ENCODE Transcription Factor Targets	1.0	null
Perturb_4260_OE_MEIS1_SRP201342	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.28754
ARID3A	JASPAR Predicted Transcription Factor Targets	1.0	null
SLC25A3	Pathway Commons Protein-Protein Interactions	1.0	null
MZ2-MEL	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.96948
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65M-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-2355-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43507
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
spiradoline-4375	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.862252
RPS24	Pathway Commons Protein-Protein Interactions	1.0	null
isradipine-5447	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
decreased hematocrit	MGI Mouse Phenotype Associations 2023	1.0	null
VDR-23849224-CD4+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
conessine-2792	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_530_KD_KLF15_SRP234742	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.70031
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.939717
MET_knockout_256_GSE25583	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.3942
lateral nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01882
HT115	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68291
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8904
BRD-K90902537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21638
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K47895166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29638
BRD-K78816149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0765
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09203
haloperidol-2663	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Mesothelioma_MESO_TCGA-MQ-A6BN-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8681_KD_ZNF827_SRP318474	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.59852
GTEX-TSE9-0011-R9A-SM-3DB7Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.984457
cortico-medial group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13695
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.58245
DDX18	Pathway Commons Protein-Protein Interactions	1.0	null
Dorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16054
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.85106
RPS3	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_94_KD_B4GALNT1_SRP127547	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.69754
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944562
CTCF_fibroblast of pedal digit skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.96122
GSE231648_4_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.6882
BAIAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06433
NCIH2073	CCLE Cell Line Gene CNV Profiles	-1.0	-2.19278
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.901307
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-1626-SM-3LK5F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59258
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.58352
niflumic acid-5490	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929508
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24352
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_increase_in_MLL-AF4_ChIP-seq_signal_371_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74651253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06755
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.644205
COL9A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05514
Dorsal claustrum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.954854
GSE169697,GSE169725_0_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38172
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.03084
Perturb_8367_KD_IGF2BP1_SRP094100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.2415
propofol-6707	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
embryonic lethality prior to organogenesis	IMPC Knockout Mouse Phenotypes	1.0	null
7511_RPS21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.584046
Lung adenocarcinoma_LUAD_TCGA-75-5147-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCM4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T5JW-1326-SM-4DM5G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03246
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.33279
7451_RPL24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.2573
IRF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lateral terminal nucleus of the accessory optic tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15501
4716_LUC7L3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.609008
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12425
dinoprost-5409	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27168
BRD-K56384721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17117
TRIM24_knockout_299_GSE19675	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.76476
LIG3	Pathway Commons Protein-Protein Interactions	1.0	null
7433_RPL11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23984
RBM25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20743
scopolamine N-oxide-5436	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE154074_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21982562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96457
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16553
BRD-K46949676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53964
BRD-K73290515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15894
BRD-K27971671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5765
496100320_PCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01258
NOS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53826
superficial stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.3164
Neoplasms	CTD Gene-Disease Associations	1.0	1.05052
USF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S341-1726-SM-3K2AK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13391
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.5918
LRRC32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52963
RPS23	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K93460493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04409
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71086
demeclocycline-3604	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-4_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8132_KD_EIF4A3_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.33974
Lateral dorsal nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08657
PMC12697907-ADVS-12-e07451-s002.xlsx-ST9A_overlap-NvM-Table_S9A_Pair-wise_Z-score_test_calculating_the_overlap_between_gene-cancer_MR_estimates_in_naïve_vs_memory_CD4_T_cells_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
MZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.888305
BRD-K86845405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25743
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
L363	CCLE Cell Line Gene Expression Profiles	1.0	1.59419
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1534
Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12926_KO_CLPB_SRP181053	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.73006
esophagus_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.864909
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-PW2O-0826-SM-48TC5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00222
5735_NOL6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.810988
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02336
fallopian tube	GTEx Tissue Gene Expression Profiles	1.0	0.863895
Perturb_9982_KD_SF3B4_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.0636
LRPPRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67638
USF1_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14245
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957273
H3K14ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8798_OE_HOTAIR_SRP352837	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.98806
Metallochaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.527
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE135350_2_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PLC/PRF/5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01159
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_3619_KO_SMARCA4_SRP127343	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BA-40-KU28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210419
Perturb_8196_KD_TIAL1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.2449
7206_RCL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.711331
gabexate-4220	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cd8 cells	HPM Cell Type and Tissue Protein Expression Profiles	1.0	1.14787
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12544
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1619
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
arcaine-3010	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05114
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24466
SNRPA1	Pathway Commons Protein-Protein Interactions	1.0	null
Peroxisomal importomer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.235
BRD-K67261586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31244
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
RPMI8402	CCLE Cell Line Gene CNV Profiles	1.0	2.14241
NOP14	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83393
propantheline bromide-4798	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Internal iliac artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
haloperidol-4427	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.724067
organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFTUD2	Pathway Commons Protein-Protein Interactions	1.0	null
KP-N-RT-BM-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.12828
ILF3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K56ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5564_KO_KDM4C_SRP375293	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.76045
Ventral posterolateral nucleus of the thalamus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66956
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.986526
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36173
MCIXC	DepMap CRISPR Gene Dependency	1.0	2.51777
lateral hypothalamic area, tuberal region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32255
deferasirox_homo sapiens_gpl570_gds3558	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SARM_KO_GDS4842_412_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71996
H3K36me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of SePal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83349
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.59231
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
carbamazepine-835	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
4780_MAK16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.775842
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.42297
Perturb_12291_KO_ERO1_ERP137480	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.29927
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0444
7569_RRS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.925745
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09203
GCIY	DepMap CRISPR Gene Dependency	1.0	2.55873
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TDOTT	DepMap CRISPR Gene Dependency	1.0	2.22186
BRD-K32195266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23341
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52523
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7570-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB33_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
S100A10	Pathway Commons Protein-Protein Interactions	1.0	null
5702_NLE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.724407
GSE138672_4_v_3_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CHERP	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26847
ZBTB33_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C6-06A-12R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.7073
Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Posterolateral visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23673
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06662
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A15330900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22018
small ribosomal subunit	GO Cellular Component Annotations 2015	1.0	null
1301_CCDC86_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.860947
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MNX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4506
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fluorometholone-6071	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6972-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8105
methyldopate-6640	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5040-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77834935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65474
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EKVX	CCLE Cell Line Gene CNV Profiles	1.0	1.40569
HNRNPA1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11781671-ppat.1012897.s015.xlsx-Tab_S1-S1_Table_The_detailed_information_of_DEGs_in_Huh7_cells_post_MSX1_overexpression_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JARID1A-20064375-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.34076
GTEX-S341-0126-SM-4AD64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62514
rRNA binding	GO Molecular Function Annotations 2023	1.0	null
LC4-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.95101
GTEX-RM2N-0726-SM-48FD5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942474
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.10794
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207444
NCI-H2085	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS34	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K61052964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9683
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02516
BRD-K78656517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20743
POLR2E	Pathway Commons Protein-Protein Interactions	1.0	null
BHLHE40_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PUF60	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SIRT6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5633_KD_BRD4_SRP142503	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.14127
TYKNU	DepMap CRISPR Gene Dependency	1.0	2.56466
496100402_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0779
GATA1_G1E-ER4_mm9_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4589
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0322
7493_RPP40_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.565711
superficial stratum of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40358
Perturb_13949_KD_CDK4/CDK6_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.05928
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.860602
HT	CCLE Cell Line Gene Expression Profiles	1.0	1.85268
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_8055_KD_IGF2BP3_SRP094100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.89892
9679_UTP11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.71195
SNRPB2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85359206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04883
SREK1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE92965_0_v_1_klf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PSPC1	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-16	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-5.07819
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22108
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BF-69-DN58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.381403
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
MRPS27	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78L-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_8050_KD_METTl14_SRP167173	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.73887
Mardepodect	DeepCoverMOA Drug Mechanisms of Action	1.0	0.62
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
etiocholanolone-3639	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PHB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.83187
diethylstilbestrol-4369	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
citiolone-3755	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K57357304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52398
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_10182_KD_RAD21_SRP225887	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.5326
SLVL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53963
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ACLY	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7889-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Weight Gain	CTD Gene-Disease Associations	1.0	1.02858
NAT10	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
carbamazepine-919	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24307
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38809
PPIL4	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215086_0_v_2_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PLAGL2_deficiency_GDS3010_139_mouse_embryonic small intestine	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NRF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.35152
flucloxacillin-6507	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
UO31	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.05749
SIX5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OC316	DepMap CRISPR Gene Dependency	1.0	2.61915
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K07009788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12287
Bladder Urothelial Carcinoma_BLCA_TCGA-LT-A5Z6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31959
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4540_KD_Bahd1_SRP126769	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.05501
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6571
BRD-K28184331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58004
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.841
SARS-BatSRBD_72Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.82395
Perturb_466_KD_ADAR1_SRP253895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.09191
BRD-K50795243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02064
GTEX-OIZH-1326-SM-3NB1H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13225
Mitochondrial translation initiation	Reactome Pathways 2024	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38976
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03796
Mammary myoepithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.337
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HTATSF1	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39V-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216043_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRRC2C	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66537
SYM-2206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40976
SALE	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58395
HNRNPH3	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ventral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38136
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67K-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.832199
TP53	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K85943445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.73614
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1124
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39282
POLD3	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.347
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Table_S1_Lists_of_translational_targets_of_MYC_in_MYC_ON_vs_MYC_OFF_P493_cells_and_their_5_UTR_sequences_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE152379_0_v_4_bach2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.72371
9804_WDR12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.88061
epivincamine-6838	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FLI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54152
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.90002
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
ZNF384	ENCODE Transcription Factor Targets	1.0	null
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12221
chlorpromazine-1700	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CUX1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.57319
NCIH1915	CCLE Cell Line Gene Expression Profiles	1.0	1.53171
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71129
RPS6	Pathway Commons Protein-Protein Interactions	1.0	null
IDRA-21	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17837
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
16651414-Supp2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3185
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEx BloodVessel 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-11.0308
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7DV-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TFEB-21752829-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PLEC	Pathway Commons Protein-Protein Interactions	1.0	null
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14346
YY1	ChEA Transcription Factor Targets	1.0	null
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral dorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.914645
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50088
FGFBP1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.575472
BRD-K70380532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17551
2131_DDX55_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509289
fulvestrant_homo sapiens_gpl570_gse22533	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrial translational initiation	GO Biological Process Annotations 2015	1.0	null
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_8144_KD_PABPC4_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.37625
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11767
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A-CA-04-2009(H1N1)_24Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.46091
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1952
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
dextromethorphan-5401	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
E2F6_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gefitinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.43
BRD-K35296094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76635
NUGC3	DepMap CRISPR Gene Dependency	1.0	2.43451
Perturb_10144_KD_STAU2_SRP216662	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.1918
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58153
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6186
H3K4me1_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A51B-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5781-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-OLIG2_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2	Rummagene Transcription Factor Associations 2026	1.0	null
MEF2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r11 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10521
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
In situ melanoma of skin_Epidermis_GSE4587	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.55979
H3K4me3_Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WFG8-0626-SM-3GILJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32068
DES_KO_GDS4804_171_mouse_young skeletal muscles	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19515
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855921
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE159678_4_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.50033
BRD-K82460510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13569
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14068_KD_ALKBH5_SRP247667	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.48252
NCIH2030_LUNG	CCLE Cell Line Proteomics	1.0	2.05808
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ES1	GDSC Cell Line Gene Expression Profiles	1.0	2.45935
TIAL1	Pathway Commons Protein-Protein Interactions	1.0	null
Main olfactory bulb, inner plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01326
p3 part of the ZL core	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51321
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.49373
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10163
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08006
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3383-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE228106_0_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17635
dactinomycin_mus musculus_gpl6246_gse21233	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K22189453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.6756
Perturb_13722_KD_RUVBL1_SRP126055	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.38873
SU-DHL-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41841
2833_FAM111A_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578815
anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28878
BRD-K37544873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72374
H4K20me1_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.883246
MED1	Pathway Commons Protein-Protein Interactions	1.0	null
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
OVK18	DepMap CRISPR Gene Dependency	1.0	2.58035
Perturb_12315_KO_AGO1_SRP136692	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
HCV JFH1_120Hour-Huh7_5_1_None_GSE29889	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.53272
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
7474_RPL4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.30786
SF3A1	Pathway Commons Protein-Protein Interactions	1.0	null
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTF2I	Pathway Commons Protein-Protein Interactions	1.0	null
Prestwick-1085-5774	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92186
HPSE	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55D-1126-SM-48FEB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992659
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271153
MATR3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Anteroventral nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.58835
ergocalciferol-3304	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.1117
Perturb_2326_KD_SF3B3_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.4885
2124_DDX47_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.878146
SPI1	ENCODE Transcription Factor Targets	1.0	null
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.5141
RBM26	Pathway Commons Protein-Protein Interactions	1.0	null
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC12480102-41525_2025_515_MOESM2_ESM.xlsx-ST12-Unnamed_2_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
central amygdaloid nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28795
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.668926
MDAMB134VI	CCLE Cell Line Gene Expression Profiles	1.0	1.61534
HDAC2	ENCODE Transcription Factor Targets	1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02615
RPS9	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K85813125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11083
Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC10172325-41598_2023_34728_MOESM5_ESM.xlsx-KD_Upregulated-Unnamed_7_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1801
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7390_KO|KD_UPF3A_ERP130415	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.18062
bladder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.14565
Perturb_7292_KI_KMT2C_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.51268
SF3B5	Pathway Commons Protein-Protein Interactions	1.0	null
Imiquimod	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
CP50-MEL-B	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.21576
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8235_KD_PCBP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.7918
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.789185
mitochondrial small ribosomal subunit	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.067771
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.17257
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09778
Perturb_15634_KO_AHCY_SRP351305	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_8191_KD_ILF2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.47799
BRD-K38692266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92368
GTEX-RUSQ-0226-SM-47JWT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13158
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.544
Perturb_8085_KD_DAZAP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.84416
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
quinisocaine-4207	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPS26	Pathway Commons Protein-Protein Interactions	1.0	null
KARPAS-422	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4911
7475_RPL5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.03029
hsa-miR-4725-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
raloxifene-2738	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8799469-41591_2021_1576_MOESM8_ESM.xlsx-Fig2e_-_E2F4_808g-SCENIC-predicted_targetome_for_E2F4_808g_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
POLR1A	Pathway Commons Protein-Protein Interactions	1.0	null
TRIM24_knockout_298_GDS3087	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.29655
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.917584
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_9406_KD_GATA6AS_SRP279802	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.70585
metitepine-6312	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
small ribosomal subunit rRNA binding	GO Molecular Function Annotations 2025	1.0	null
GTEX-WFG8-0126-SM-4LVMH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856348
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
16_AATF_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.596885
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1651
NCIH838	CCLE Cell Line Gene Expression Profiles	1.0	2.52867
BT12	DepMap CRISPR Gene Dependency	1.0	2.62111
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276137
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3529	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88154
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6664
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitochondrial translation	Reactome Pathways 2014	1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855921
OCIAML2	DepMap CRISPR Gene Dependency	1.0	2.45662
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28378
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00206
erastin-6369	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ATAD3A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08798
Infertility, Female	CTD Gene-Disease Associations	1.0	1.2772
Perturb_15098_KD_PDHA1_SRP385600	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.69773
SARS-CoV MA15_Day7_None_GSE49263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.60235
riboflavin-4485	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TFAM	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDVJ-0426-SM-2I5FW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11191
4713_LTV1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516838
SPI1_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM6A	ChEA Transcription Factor Targets	1.0	null
BRD-K74908937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05088
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4686
Primary somatosensory area, upper limb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31082
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2701
ZNF479	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89918
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
procaine-5430	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MRPS23	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-N7MT-0126-SM-2D7VT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895458
Prelimbic area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15057
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MEF2C	ENCODE Transcription Factor Targets	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
CRCGN014_HEPG2_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18501
Perturb_9922_KD_PCBP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
HNRNPF	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ribonucleoprotein complex	GO Cellular Component Annotations 2015	1.0	null
GATA1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
10703_ZNRD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.767281
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I2-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200679
tubocurarine chloride-5449	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4909_KD_IMP1_SRP070819	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.52586
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7547
TEAD4	ENCODE Transcription Factor Targets	1.0	null
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
PMC10214295-mmc4.xlsx-A_-_Human_Islets_ZBTB16_targets-Gene_Name_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.14365
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mitochondrial small ribosomal subunit	GO Cellular Component Annotations 2015	1.0	null
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20106
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.04566
CKAP5	Pathway Commons Protein-Protein Interactions	1.0	null
HCC-38 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.995
ventrolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22886
organellar ribosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SNRPD1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEx AdiposeTissue 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-17.0108
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.0074
Sox3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.3917
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LCLC-97TM1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.43465
UM-UC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05114
SRF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9_OE_ERG/MYC_SRP069177	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.79841
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.24651
OE21	DepMap CRISPR Gene Dependency	1.0	2.20326
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A59449038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30265
10703_ZNRD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.57902
NFIC_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25167
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04579
H3K4me1_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42403
Perturb_13948_KD_CDK4/CDK6_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.47473
A4FUK	CCLE Cell Line Gene Expression Profiles	1.0	1.37969
Lung squamous cell carcinoma_LUSC_TCGA-77-7335-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EOL1	CCLE Cell Line Gene CNV Profiles	1.0	1.6762
BRD-K69269415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.083
Prestwick-682-4984	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_10051_KD_PRPF8_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.3949
GSE240027,GSE240030_1_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TOLEDO	CCLE Cell Line Gene CNV Profiles	1.0	1.4132
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_9885_KD_HNRNPL_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.04554
mitochondrial translational elongation	GO Biological Process Annotations 2015	1.0	null
Perturb_17578_KD_ASCL2_SRP271644	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.4236
H3K79me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RT-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158932
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3473-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
valproic acid-5211	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ML-265	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
MYBL1_KO_GDS4485_349_mouse_Testis from 14 day old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
desipramine-3212	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.35593
embryonic growth arrest	MGI Mouse Phenotype Associations 2023	1.0	null
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287843
FOXP3-21729870-TREG-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PTBP1	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1	ENCODE Transcription Factor Targets	1.0	null
CKLF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63848
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.61476
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K33912919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13434
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MGME1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65267
Perturb_7314_KO|KD_UPF3A_ERP130416	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.43548
ATF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3693_KO_GPX8_SRP353993	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.13167
POU5F1	ChEA Transcription Factor Targets	1.0	null
Perturb_12139_KD_PRPF38A_SRP093921	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
HT29	BioGPS Cell Line Gene Expression Profiles	1.0	1.07631
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AG-013608-6400	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
5733_NOL11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.787464
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40863
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
BHLHE40_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31016
Organelle biogenesis and maintenance	Reactome Pathways 2014	1.0	null
dorsolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.877002
BRD-K47337578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22749
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.05424
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I4-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83276
SLC1A3	Pathway Commons Protein-Protein Interactions	1.0	null
6576_POP5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.517167
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.61647
Perturb_14230_KO_Dpagt1_SRP230444	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.98921
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16968_KD_NRF2_SRP218850	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.7528
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.7395
BRD-K77207661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1364
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.52228
5707885-6433	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_1058_KO_ALPG_SRP277076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.23336
JUN_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HUH6	DepMap CRISPR Gene Dependency	1.0	2.63722
molsidomine-5426	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC10214295-mmc4.xlsx-A_-_Human_Islets_ZBTB16_targets-Ensembl_Gene_ID_ZBTB16	Rummagene Transcription Factor Associations 2026	1.0	null
2127_DDX51_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.521389
HUH6	CCLE Cell Line Gene Expression Profiles	1.0	2.53641
KYSE-150	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.83445
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
POLR2A_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_754_OE_METTL3_SRP393226	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.42275
Perturb_7012_Mut_Htt_SRP043967	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.5115
meclofenoxate-4729	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC12571111-qiaf131_supplementary_data.xlsx-ST2-Supplementary_Table_2_Results_of_the_two-sample_MR_analysis_on_the_causal_role_of_CD4_T_cell_expression_profiles_on_CRC_development_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5205
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.69328
Brain Lower Grade Glioma_LGG_TCGA-S9-A6TV-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5601
H3K4me1_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC6327858-mmc2.xls-exon_skipping-List_of_alternative_splicing_modified_by_Digoxin_treatment_50nM_for_48h_in_DM1_hESC_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CDC7_knockdown_109_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.87685
CIRBP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K97391170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75236
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
piretanide-3567	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_11523_KD_NR0B1_SRP092641	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.30444
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Mitochondrial matrix	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SRF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5731_NOC4L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.598064
BRD-K26443253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19755
Sarcoma_SARC_TCGA-DX-A6B8-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6551
GTEX-P4QS-1326-SM-3NMCD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32324
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
yohimbic acid-4082	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular component disassembly	GO Biological Process Annotations 2015	1.0	null
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPA3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K56ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ondansetron-5796	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
7518_RPS27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.6383
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR3C	Pathway Commons Protein-Protein Interactions	1.0	null
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.67524
amantadine-3280	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_8990_KD_PSENEN_SRP329252	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.98572
cyclizine-5100	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K52592505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09765
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prestwick-692-2820	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YJ-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1129_SPOUT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.964341
7451_RPL24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.40344
GTEX-XOT4-0626-SM-4B66L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867344
IRAK4_knockout_41_GSE12124	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.07047
5909_NVL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.795022
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RELA_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_629_KO_SOX4_ERP117895	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.25776
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
Hodgkin lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.122
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K27889081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06828
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE180	DepMap CRISPR Gene Dependency	1.0	2.41309
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3445_GNL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.764844
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K33503286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77206
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45176
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.903429
GTEX-T5JC-0826-SM-32PMC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899385
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34546
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.4617
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K68438316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12842
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25715
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2371_KO_TET2_SRP163132	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.80519
H3K79me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FXR1	Pathway Commons Protein-Protein Interactions	1.0	null
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAPRIN1	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4642	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4780_MAK16_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.846506
Perturb_2309_KD_DHX8_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.17729
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.387254
GTEX-QDVN-1326-SM-48TZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990762
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.962433
Brain Lower Grade Glioma_LGG_TCGA-HT-A61B-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.9085
BRD-K92569554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85544
LARP4	Pathway Commons Protein-Protein Interactions	1.0	null
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0951
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFATC1	ENCODE Transcription Factor Targets	1.0	null
GSE216043_11_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44878
lateral nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.943681
FOSL2	ENCODE Transcription Factor Targets	1.0	null
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.21064
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214654
dicoumarol-3941	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5766
9839_WDR74_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.509402
H3K27ac_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Sjogren-Larsson syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
SFPQ	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11278
BRD-K20661169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01197
859_BMS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.625335
quercetin-917	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15785
HARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02079
Perturb_10053_KD_RRP9_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.67052
LOUCY	GDSC Cell Line Gene Expression Profiles	1.0	1.63734
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.77591
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72546
GTEX-O5YT-1326-SM-3MJGR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63723
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAUZ-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27091
E2F4_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U266B1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.94909
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201361_0_v_1_mpst_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ansiform lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22361
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05927
BRD-K98876398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37161
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.1887
GSE235828_3_v_2_igf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
prazosin-5416	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SOX15	Pathway Commons Protein-Protein Interactions	1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.524497
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_9925_KD_RBM34_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.40103
EP300	ENCODE Transcription Factor Targets	1.0	null
7502_RPS14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.527182
Perturb_13393_KD_AHR_SRP154013	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.88881
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16916
NRF1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BCLAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vincamine-3784	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
failure of primitive streak formation	MGI Mouse Phenotype Associations 2023	1.0	null
ADAM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11747
HNF4A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K44141416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54463
Perturb_8240_KD_SF3B4_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-14.4919
blastocysts	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.70368