association dataset threshold value standardized value MDAMB415 DepMap CRISPR Gene Dependency 1.0 3.54825 Stat5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.8241 COGE352 DepMap CRISPR Gene Dependency 1.0 2.3407 BRD-K74148702_curcumin_JHUEM2_6.0_h_48.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CSAD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00442909 TNNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6236 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 2.3706 BRD-K79494396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08244 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.872315 single-organism process GO Biological Process Annotations 2015 1.0 null FNDC4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00575188 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.68726 WM115 CCLE Cell Line Gene Expression Profiles -1.0 -1.46504 GPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22996 hsa-miR-559 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 RERFLCAD1 CCLE Cell Line Gene Expression Profiles -1.0 -1.46814 NCIH1092 CCLE Cell Line Gene Expression Profiles -1.0 -1.48734 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null storeoperated GeneRIF Biological Term Annotations 1.0 null GLS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00950316 BRD-K09549677_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-4477b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 BRD-K59437706 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20737 SPIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7641 CTSW LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00562605 CRCGN016_MCF10A.TP53.M_24H:O18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.05709 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.303559 BRD-K47983010_BX-795_NCIH1694_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SNU81 DepMap CRISPR Gene Dependency 1.0 2.13143 REG3A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00544167 BRD-K61796560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.23099 CRCGN011_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.28505 CRCGN014_HEPG2_24H:B12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.30018 G22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.9138 increased circulating alanine transaminase level MGI Mouse Phenotype Associations 2023 1.0 null BRD-K34262858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.66975 BRD-K05153001_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LIN28A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60968 rectal cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.57082 SUDHL5 CCLE Cell Line Gene Expression Profiles 1.0 1.53129 hsa-miR-1244 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 COBL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00437598 SMIM19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.24732 HOXD9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 62.7965 NCI-H2227 GDSC Cell Line Gene Expression Profiles 1.0 1.65558 BRD-K44067360_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF518A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.01442 GSE200352_1_v_8_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null CHD4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00606525 ST8SIA6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00495289 CREBBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19665 sucrase-isomaltase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.187 16455954-TableS2 GeneSigDB Published Gene Signatures 1.0 null valproic acid-346 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RIPK4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00796048 Pseudomyxoma peritonei DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.456 TSPYL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57952 BRD-K13390322_AT-7519_HME1_24_h_0.37_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.WT.HP_24H:E10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.3746 GSE139948_3_v_2_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.43337 alimentary canal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 BRD-K18621941 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1524 GSE183251_1_v_5_cyp2c70_mouse RummaGEO Gene Perturbation Signatures -1.0 null PRKAA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00574164 ROCK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28775 BRD-K03829970_-666_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K91419355 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13883 ENSG00000284691 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30719 CSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.89681 Cerebral lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.932885 NCIH446 DepMap CRISPR Gene Dependency 1.0 3.6652 ODF3L1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00966625 outer SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.15436 ZNF681 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25048 C3orf38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80225 VASH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.81614 BRD-K48813201 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27077 PER2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40423 BRD-K17075857_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null colonic cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.740915 STK36 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00662465 GRIK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00657609 VAMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07787 PLS3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00668332 496100593_TCx_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.81869 PMC4060771-170289.f1.pdf-287-MSX2_MSX2 Rummagene Transcription Factor Associations 2026 1.0 null HELA BioGPS Cell Line Gene Expression Profiles 1.0 0.924988 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A8AZ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACSM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71391 CCAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66246 PRPF40A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1541 BRD-K23841751_HTS 10859_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MRE11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00904579 PARP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61415 GSN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00673373 NCKIPSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64626 Intestinal benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.192 NFKBIE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50366 BCL7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58 BRD-K56120807 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23454 ARHGAP24 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00568973 SMYD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0049565 CAVIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00768 ZNF727 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06846 CRCGN010_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.09482 BRD-K50140147_NVP-TAE684_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IRF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.5 U178 CCLE Cell Line Gene Expression Profiles -1.0 -2.19729 BRD-K76426411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89708 BRD-K77908580_-666_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BIN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00892062 TP53RK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00636483 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0852 BAG6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23826 PANX1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00728655 cdx1 GeneRIF Biological Term Annotations 1.0 null divalent inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null substrate-specific channel activity GO Molecular Function Annotations 2015 1.0 null Colon cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.794 ABCA6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00631221 CDX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.2661 CTCF ENCODE Transcription Factor Targets 1.0 null ZWINT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71003 Mucosa TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.6037 TK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00676755 hsa-miR-3617 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 BRD-K66884694_NCGC00167398-02_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SN12C GDSC Cell Line Gene Expression Profiles -1.0 -3.08956 ligand-gated channel activity GO Molecular Function Annotations 2015 1.0 null BRD-K99198579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20964 THY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06086 CRCGN016_MCF10A.TP53.M_24H:P18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3119 NADK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00639201 RERF-LC-FM COSMIC Cell Line Gene Mutation Profiles 1.0 null ABCD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00571362 ACSM2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0080668 BRD-K78380066 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02972 CRCGN016_MCF10A.TP53.M_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.42608 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.40958 TULP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00503 PYCARD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.73455 BRD-K05686172 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03739 BRD-K16485616_S1122_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PTGFR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00596726 SCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93853 AP3B1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00884742 gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.319863 PELI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99235 ALAD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00655904 ventrolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.825512 TUBD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13382 ANXA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00339619 KCTD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0813 PPP1R16B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00652234 PHACTR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47187 FOXD4L6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33678 PRSS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00565797 Anchored component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.421 Alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CCDC59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83665 GSE200352_5_v_8_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null FPGS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00339029 TRMO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91517 large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.530298 BRD-K34581968_BMS-536924_SKMEL28_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LB831-BLC GDSC Cell Line Gene Expression Profiles 1.0 1.50171 orbital frontal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11193 Forebrain TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 DB CCLE Cell Line Gene Expression Profiles 1.0 1.97136 metal ion transport GO Biological Process Annotations 2015 1.0 null POLR1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88402 hippocampus (hippocampal formation)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02285 BRD-K08206212_S1252_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K68548958_-666_HA1E_24.0_h_20.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TLK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98719 ODF2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15979 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35567 PFKFB1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00628613 C3A CCLE Cell Line Gene Expression Profiles -1.0 -2.1018 NUF2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00399521 MCMBP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00452992 SLC19A3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00565759 SP140 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00521915 BRD-K52339692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16755 FOXO6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.8118 BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K06666320_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K09991945_GSK-3-inhibitor-II_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A06352508_SB 218078_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.WT.HP_24H:P15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1394 BRD-K13566078_HY-10518_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null C4orf36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65416 SLC1A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0049499 CELF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51352 MYF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94761 TAOK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00540119 periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.34475 Lung adenocarcinoma_LUAD_TCGA-44-6145-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-QH-A6XC-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 69.6537 RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.4169 dorsolateral prefrontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20392 colon BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 BRD-K57042334 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15524 GSE124048,GSE124067_1_v_0_irf6_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYO1G LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00505913 TBX19 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2156 osteoblasts BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.72246 MDAMB415 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.29758 RIPOR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00805814 Brain Lower Grade Glioma_LGG_TCGA-S9-A7IZ-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:M01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.38301 NPHS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00590548 MZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.993306 KYO1 DepMap CRISPR Gene Dependency 1.0 6.84061 BRD-K06935782 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02883 TRIM52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00067 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.11968 NR3C1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K84115096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03187 myricetin-4170 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26052 FOXF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47277 GSE184884_7_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CerebellumPeduncles BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.838537 NADSYN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70836 BRD-K63068307_S1072_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TP53 ChEA Transcription Factor Targets 1.0 null LRATD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82559 Perturb_3797_KO_BRG1_SRP165661 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 EPHB3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0046035 USB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14415 BRD-K44402256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68734 Sarcoma_SARC_TCGA-DX-A8BH-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TM6SF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00583326 CUX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6738 ZNF184 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 67.1868 CRCGN016_MCF10A.TP53.M_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.7309 interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.825015 SCC15 CCLE Cell Line Gene CNV Profiles -1.0 -1.51045 BRD-A20126139_MEDRYSONE_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOXA1-21572438-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51043 BRD-A72180425_K784-3188_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PPP1R7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16213 ligand-gated ion channel activity GO Molecular Function Annotations 2015 1.0 null JHOS2 CCLE Cell Line Gene Expression Profiles 1.0 1.40346 PLA2G2D LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00459924 BRD-K28057105 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53067 NTMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.83647 abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.58623 MEWO COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K36055864_CYCLOHEXIMIDE_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF146 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23078 dependent GeneRIF Biological Term Annotations 1.0 null PIWIL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84481 TRERF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.673 SW 620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12579 GSX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20658 p3x63ag8.653 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.66 cation transmembrane transport GO Biological Process Annotations 2015 1.0 null BRD-K60437668 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53699 HCC-56 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-A45498368_WYE-125132_HCC515_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SUV39H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78883 ZNF106 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84613 HCC1482 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.57607 CEACAM7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00807056 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CKM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00940398 BRD-K71758378 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10751 excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Colonic cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.506 KU1919 CCLE Cell Line Gene Expression Profiles 1.0 3.40818 CLEC10A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00756646 MON1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01088 BRD-K24132293_piperlongumine (HPLC)_U937_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null C15orf40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13896 hsa-miR-548w TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 internal segment of globus pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.85443 BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EIF2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59208 HEMK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0104 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.99308 NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null C6orf62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61602 imatinib_homo sapiens_gpl96_gds3044 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SPTLC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30836 KCNK15 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00420141 HDDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84623 IZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33289 PCNX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34011 RDX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56506 AKR1A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00591845 SDR39U1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52272 stomach TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.160203 SLC38A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0079632 WM2664 CCLE Cell Line Gene Expression Profiles -1.0 -1.98047 HCC1419 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.30746 NHEJ1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00655737 PFEIFFER CCLE Cell Line Gene Expression Profiles 1.0 2.65491 amygdaloid complex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.93304 primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.836823 MSANTD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83297 ZNF823 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69841 HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.88914 CD300C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00581895 BRD-K86958018_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K69585439 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89097 LPP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7796 KDM5D LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00358439 MST1R LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00535005 medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.826354 SNAI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3531 CRCGN017_MCF10A.WT.HP_24H:P10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8562 CRCGN017_MCF10A.WT.HP_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.16475 ZDHHC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48274 BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SH3BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60142 NDUFAF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7873 BST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82319 NR3C1 ENCODE Transcription Factor Targets 1.0 null chromatin GeneRIF Biological Term Annotations 1.0 null PCNT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04796 magnocellular (medial) division of MD Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.72125 Pancreatic adenocarcinoma_PAAD_TCGA-YY-A8LH-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.868714 Kidney TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11075 BRD-K81575721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0969 cellular_component GO Cellular Component Annotations 2015 1.0 null BRD-K64800655_HY-11001_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0397 BRD-K64788035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20282 CEP68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78549 colorectal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.57082 ARHGEF15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90776 ISTMES2 CCLE Cell Line Gene Expression Profiles -1.0 -1.76099 CRCGN015_HEPG2_48H:B18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.49545 Gastrointestinal system benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.069 OPRK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00839642 inorganic cation transmembrane transport GO Biological Process Annotations 2015 1.0 null MAT1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71858 TCF7L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.7065 INSYN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.50388 FAM78A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6839 JURKAT BioGPS Cell Line Gene Expression Profiles -1.0 -1.61968 BRD-A52530684_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MIDN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76037 WDR83 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86326 testis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.968477 hsa-miR-4670-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 MS4A18 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00516848 lm1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.025 LAD-2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.752 BRD-K75293299 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.80507 TTC642 DepMap CRISPR Gene Dependency 1.0 3.08857 HRH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13004 GSE216043_3_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.783 GSE201520_8_v_3_inhba_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF639 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01076 BRD-K78989575 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14739 KSR1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00589243 PL4 DepMap CRISPR Gene Dependency 1.0 8.56202 BRD-K71726959_N9-isoproplyolomoucine_SKM1_6.0_h_122.55_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 496100541_FWM_possible Alzheimer's disease_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 7.68721 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.217974 RGS12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71152 MED12L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.3298 EN DepMap CRISPR Gene Dependency 1.0 2.76916 BRD-K88449712 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0997 CRCGN017_MCF10A.WT.HP_24H:O14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04685 BRD-K81941590 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.3391 primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.3827 CRCGN016_MCF10A.WT.HP_24H:G10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.24705 CPHXL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57806 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7837-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null colorectum TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CHD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12452 BRD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00554931 ZNF442 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13405 CPOX LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00550128 SYNJ2BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35357 CRCGN016_MCF10A.TP53.M_24H:K12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.43237 epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.072761 BRD-K44432556_VU0418946-2_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PTPN14 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00714682 PBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.456 inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.65748 SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17002 BTN3A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58781 enlarged lymph nodes IMPC Knockout Mouse Phenotypes 1.0 null CRCGN015_HEPG2_48H:H19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66053 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH727 CCLE Cell Line Gene CNV Profiles 1.0 1.75484 BRD-K17003857 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42685 integument TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CRCGN015_HEPG2_48H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.90185 BRD-K62459624_T5212475_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null STK25 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00298902 GATA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6016 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15711 RB1_KD_GSE50532_656_human_OSTEOBLASTS GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CRCGN017_MCF10A.TP53.M_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.96962 PMC6529539-41598_2019_43492_MOESM3_ESM.xls-Table_S2a-Table_S2a_Normalised_log2_data_of_OriGene_and_Montpellier_samples_profiled_using_the_standard_protocol_Normalised_to_HKs_RPL13a_PPIA_ZNF384_ZNF384 Rummagene Transcription Factor Associations 2026 1.0 null ZBTB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35796 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SIN3A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00724997 SLC23A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79878 GNMT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0064339 CRCGN014_HEPG2_24H:F21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.02304 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VMRCLCD DepMap CRISPR Gene Dependency 1.0 4.98279 ARFGAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1525 SH3BP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17309 HAGH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81742 BRD-K55844427_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TRPV5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00549243 ENTPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26604 ELK1::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9982 CRCGN017_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9128 IZ in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05269 BRD-K13390322_AT-7519_HA1E_24_h_1.11_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 BRD-K87909389_HY-10005_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MLH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72213 MZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01099 TRIM21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9329 SAMD4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32864 ECPAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7001 BRD-K07762753_-666_NEU_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TRIM44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32417 BRD-K56653679_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TRMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.9685 BRD-K10882151_BO2 (inhibits RAD51)_SKMEL28_6.0_h_40.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A06837695 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22628 DRG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24981 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null KCND3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00557213 CHMP2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5238 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.313 hsa-miR-548ak TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 ZNF214 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7106 BRD-K44494409 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33226 K562 BioGPS Cell Line Gene Expression Profiles 1.0 1.15335 BRD-K97805186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32528 IKBKB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.24152 SLC47A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00546457 clozapine-4453 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IPC-298 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.68804 CCM2L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00625017 Lung adenocarcinoma_LUAD_TCGA-44-6147-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K47869605_PODOFILOX_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K13566078_BMS-345541_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE191015_0_v_2_gsdmb_human RummaGEO Gene Perturbation Signatures 1.0 null HOOK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67357 KYSE-30 COSMIC Cell Line Gene Mutation Profiles 1.0 null PGK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00544982 BRD-K75710654 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.04718 BRD-K78599730_manumycin A_A375_24.0_h_9.08_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K87909389_F3055_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COL4A5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0066954 ZNF267 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47511 BRD-A27554692_ALTRENOGEST_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OF-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Colonic epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.467 ZNF329 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25489 Sox6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.4177 BRD-K54704028_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SETBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15779 SW684 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-A02333338_C3393M50_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K22674439 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41417 primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.67901 Urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25194 BTLA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00622022 RFLNB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8933 BRD-K05902089 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41814 RWDD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79322 CRCGN012_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.39027 APPBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04482 BRD-K56065989 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0141 NCF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00480359 GSE200352_5_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null PDXP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2125 MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.79402 SPSB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53727 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29864 Stomach disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.009 TRAF4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00646649 FREY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22373 A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.974812 MAST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4084 hsa-miR-129-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GXYLT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35831 ALDH3B1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00501614 ASPM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53386 BRD-A46566149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22314 Hippocampus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 SF268 COSMIC Cell Line Gene Mutation Profiles 1.0 null KDSR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78485 HAPLN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96248 CRCGN009_HEPG2_24H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17701 IFI44 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00680789 DTX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6097 hsa-miR-548ab TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NM-01A-21R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Appendix cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.353 CYLD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00708604 CZIB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4748 BRD-K42296822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56531 POLK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67247 transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null BHLHE23 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.1352 EPS8L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03443 VZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.831832 BRD-K23192422_L-6307_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE254848_4_v_3_ptges_mouse RummaGEO Gene Perturbation Signatures -1.0 null TDRD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57512 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.55 CRCGN014_HEPG2_3H:L18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27434 dorsalrootganglion BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.25497 BRD-K00615600_AG14361_NCIH1836_6.0_h_25.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7606-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC1A7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0043772 PRPF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83739 BRD-A79465854_auranofin_SW948_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K91701654_70970_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HTR3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.57928 OLIG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0307 NMB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00615161 PIM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00637128 LAMTOR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55773 NCIH716 CCLE Cell Line Gene CNV Profiles -1.0 -2.35139 BRD-A13122391_16-HYDROXYTRIPTOLIDE_A375_24.0_h_0.08_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NR3C1_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null IAH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41639 TSPAN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75252 ASPM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00513857 BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.891163 BRD-K40954438 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15717 SLC25A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86494 LRRC45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71063 MZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19422 GABARAPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2442 BRD-K99300752 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65361 IL23R LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00539991 TBC1D10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92403 BRD-K92093830_-666_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IH-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K07237224_4-chloro-n-(2-morpholin-4-yl-ethyl)-benzamide_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE148695,GSE167281_0_v_1_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null TFAP4::ETV1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.4342 PMPCA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00582176 BRD-A43331270_niguldipine hydrochloride_SW620_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NR4A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00645133 CNOT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25986 CASP9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00690148 MYF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.3968 GAD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00478813 hippocampus HPA Tissue Protein Expression Profiles 1.0 0.990082 INS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00891295 RSKR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00604248 CRCGN011_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2815 NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null NCM-460 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.527 SK-HEP-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.67799 SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.97282 DAPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43076 FAIM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12272 SW962 GDSC Cell Line Gene Expression Profiles 1.0 1.53757 Yy1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.1099 496100635_HIP_dementia_TBI_77_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 6.1825 DND-41 COSMIC Cell Line Gene Mutation Profiles 1.0 null CABLES2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57985 ENO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5281 SLC7A9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00497557 SDCBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11762 ZFYVE21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66764 BRD-K69564473 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04847 CRCGN017_MCF10A.WT.HP_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.46804 processes GeneRIF Biological Term Annotations 1.0 null PLA2G2E LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00714715 CRCGN016_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.6762 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J4-A83I-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GR MotifMap Predicted Transcription Factor Targets 1.0 null ZKSCAN5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.156 BRD-K89930444_AG 592_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null COQ5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51814 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08149 SW579 DepMap CRISPR Gene Dependency 1.0 4.25433 Mitochondrial large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.187 SOX12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7506 COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08316 CD20-like family InterPro Predicted Protein Domain Annotations 1.0 null BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.83771 SRP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04179 BRD-K95858622_NCGC00182609-01_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KLF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27464 SP in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.46449 ion transmembrane transport GO Biological Process Annotations 2015 1.0 null CRCGN009_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.13418 ZNF662 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54819 HCC1599 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.855496 TUBB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7536 SLC16A11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.42674 ZMPSTE24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0245 ZNF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98484 AIMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2995 LIPC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00541906 muscle GTEx Tissue Gene Expression Profiles -1.0 -1.00701 BRD-A30437061_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Axonemal dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.849 ZNF616 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3066 YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51043 CRCGN008_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4044 MTHFSD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1607 BRD-K71437774 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23821 BRD-K27120020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21157 BRD-K67998155 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63093 exisulind-314 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null YOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87353 gastrointestinal cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.726507 BRD-K77465015 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47688 AGGF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74213 TP53-16413492-CHIP-PET-HCT116-HUMAN ChEA Transcription Factor Targets 2022 1.0 null KIDINS220 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28664 BRD-K10846167_N-((1H-naphtho[2,3-d]imidazol-2-yl)methyl)-2-morpholino-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054666 BRD-K11927976_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null UPF3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06883 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K31758107 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26633 CRCGN013_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.61144 BRD-K04853698_LDN-193189_HEPG2_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ADCY1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00553494 BRD-K29506255_NCGC00185087-01_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16208 Nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CTCF-21964334-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-A71001587 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08315 GJD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94398 transcript GeneRIF Biological Term Annotations 1.0 null NCIH889 CCLE Cell Line Gene Expression Profiles -1.0 -1.45768 BRD-K11219023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1088 SLC45A3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00628107 TRIM27 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00532721 biological_process GO Biological Process Annotations 2015 1.0 null posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31591 UBE2D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6906 BRD-A45889380_QUINACRINE HYDROCHLORIDE_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10604 MM77 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.71703 CRCGN014_HEPG2_3H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17195 BRD-K43390080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0701 HS834T CCLE Cell Line Gene Expression Profiles 1.0 1.6861 RASSF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01859 hsa-miR-4714-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 CRCGN016_MCF10A.TP53.M_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1876 SUMO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43279 BRD-K26767475_NCGC00183255-01_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 69.5588 PODXL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22438 CRCGN015_MCF10A_48H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.23159 IFNA2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00659457 MEF2D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.479 CRCGN008_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.5347 KALRN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00560694 CSGALNACT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25121 INHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41989 ZBED2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00570368 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PIK3C2G LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00430203 CARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.62919 SAR1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00547401 DEFB4A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00753541 CRCGN015_MCF10A.TP53.M_24H:L21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5923 CHUK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93528 RPL13A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80865 BRD-A13122391_16-HYDROXYTRIPTOLIDE_HT29_24.0_h_0.08_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null AMD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00467679 CRCGN015_HEPG2_48H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.20151 KP3 CCLE Cell Line Gene CNV Profiles 1.0 1.54939 CRCGN017_MCF10A.WT.HP_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.49245 FOXB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.9053 H2BK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.02322 TUBE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6376 SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.92155 cell surface COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.411039 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USP7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00490648 BRD-U51951544_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GCSAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.43574 Brain Lower Grade Glioma_LGG_TCGA-VV-A86M-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K06666320_-666_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sarcoma_SARC_TCGA-X6-A7WB-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K55927371 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01242 CRCGN015_HEPG2_48H:J17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.33707 NR3C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.9313 Large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.855 SFRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.34031 RXRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.5221 FAM86B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23723 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040629 EIF4G1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00717199 BRD-K06355852 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29445 ZEB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05939 NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.879929 ATF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30312 PECAM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00765468 WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.890516 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26052 BRD-K92627732 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01053 BRD-K20755323_-666_SKMEL28_6.0_h_40.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K28296557_Akt inhibitor IV_SKMEL28_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ADD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18706 BRD-K55316222 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15582 heart GTEx Tissue Gene Expression Profiles -1.0 -0.866151 central part of CEl Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.898844 CRCGN012_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.51756 BRD-K86300178 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17616 MYPOP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28587 CRCGN014_HEPG2_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.18987 CDC14C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63896 PDCD6IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34597 DEPDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59472 ZNF821 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92802 MEF2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71949 NR2C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.2589 ZNF263 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.9362 FIZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87066 GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRAPPC6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08408 urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hsa-miR-548u TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 rectal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.57082 Gut epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.02 CRCGN009_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.02542 DCLK3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00648578 CUX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.68696 NELFE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.63177 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2796 GATA2 ENCODE Transcription Factor Targets 1.0 null hippocampus (hippocampal formation)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.850252 TNFAIP8L2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00688315 UBE2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3684 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null CLEC1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00770647 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.890516 HAND2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39704 JADE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70116 CRCGN015_HEPG2_48H:P04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.11326 BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null caudal subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.72172 Lung adenocarcinoma_LUAD_TCGA-44-6146-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE200352_4_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K50168500_S1019_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K08554278_Hoechst 33342 (cell permeable) (BisBenzimide)_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P0-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K86472598_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51108 SETDB1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00463301 DNAJC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.25803 KCTD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17981 DOT1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55636 BEND5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51535 BRD-K28470988_L-690,330_EFO27_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K47983010_BX-795_U937_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.41143 CRCGN014_HEPG2_24H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.674 ZFHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97921 SKBR3 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.20905 PPM1G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89321 Left colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.026 ZBTB7A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1471 NR3C1_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3469 A-673 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.92739 BRD-K49309964 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36865 NPAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21727 BRD-K56470219 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00641 CRCGN015_HEPG2_48H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.58249 hsa-miR-576-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 CCR3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00705154 HELZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55233 BRD-K95609758_-666_RKO_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FHIT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00609254 EFO-27 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZR751 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.97048 ZBED6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.72652 SLC25A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00543689 MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USP46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.52393 A4FUK CCLE Cell Line Gene Expression Profiles 1.0 1.90626 IRF7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00626931 BRD-K83794624_P8624_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11157 CRCGN015_HEPG2_48H:F16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.92545 BRD-A59985574_T542500_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN012_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.79431 LAMTOR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51372 CUL7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44457 HCC202 DepMap CRISPR Gene Dependency 1.0 2.47616 CRCGN013_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.47043 GPR153 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82721 intestinal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.550901 CAMK2D LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00743449 BRD-K49669041_HY-11005_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOXR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82707 GSE133691_2_v_0_lgr5_mouse RummaGEO Gene Perturbation Signatures -1.0 null substrate-specific transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null XPO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81688 SJRH30 COSMIC Cell Line Gene Mutation Profiles 1.0 null urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K92913067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19982 IL12B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00660235 GRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38484 posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18768 BRD-A77577770_AC-1121_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A56592690_PX12_NCIH1694_6.0_h_30.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.84503 striatum_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.874282 BRD-K10484463_1483-0018_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MMP13 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00326385 C2CD4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27302 BRD-K26217579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20097 RRN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88206 ZCCHC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50816 dorsolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08794 SF295 BioGPS Cell Line Gene Expression Profiles -1.0 -1.04197 lateral ventricle HPA Tissue Protein Expression Profiles 1.0 1.59469 BRD-A04975445 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05387 SLC46A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58285 Brain Lower Grade Glioma_LGG_TCGA-DU-7304-01A-12R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K79390395_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05939 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 EBC1 CCLE Cell Line Gene CNV Profiles 1.0 2.02936 SUM159PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.683635 CRCGN017_MCF10A.TP53.M_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.9826 hsa-miR-3674 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 CRCGN011_HEPG2_24H:H06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01025 RCHACV CCLE Cell Line Gene Expression Profiles 1.0 1.55534 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2121 ABTB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00598876 NUSAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80935 BRD-K32718856 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.21958 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03555 HGFAC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00582611 PLA2G1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00747549 TE-11 GDSC Cell Line Gene Expression Profiles 1.0 2.18794 DKKL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93193 BRD-K19800225 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35651 FKRP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.46541 SLC31A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70004 mediodorsal nucleus of thalamus_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.927463 CRCGN015_MCF10A.WT.HP_24H:A18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.10263 BROX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52631 BRD-K49345010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76602 CRCGN010_HEPG2_24H:A08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5767 BRD-A13122391_16-HYDROXYTRIPTOLIDE_COV644_6.0_h_0.08_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H1573 GDSC Cell Line Gene Expression Profiles 1.0 1.90314 BRD-A19500257_geldanamycin_HEPG2_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.862676 EMX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.05728 ADAMDEC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00592589 DAAM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87991 PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL-29 COSMIC Cell Line Gene Mutation Profiles 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null FTSJ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06946 Multimerin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.002 PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null IFNA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00688949 cerebellar cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.825512 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null GAB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45959 macrophage BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.4471 BRD-K43473008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13247 BRD-K80950551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00888 CEBPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71397 PRC2_EZH2_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null GSE96777,GSE96778_3_v_2_zbtb4_human RummaGEO Gene Perturbation Signatures -1.0 null EIF4ENIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77114 NR3C1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180800,GSE180801_0_v_5_tex10_mouse RummaGEO Gene Perturbation Signatures 1.0 null SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.69749 ESYT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56454 ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null SLC38A5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00597497 SDHD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00513536 BRD-A04706586_Dibutyryl-cAMP, sodium salt_COV644_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RNASE11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26347 ACAD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69093 COX20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64307 primary auditory cortex (core)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02166 cellular process GO Biological Process Annotations 2015 1.0 null PRRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82262 ZNF22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49918 BRD-K15563106_-666_SW948_6.0_h_177.6_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K77908580_S1053_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17139 BRD-K90697691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14797 TUBD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00685265 BRD-K66754362 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21325 BRD-K07928699 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46291 MALME3M CCLE Cell Line Gene CNV Profiles -1.0 -1.65417 Ebolavirus(ZEBOV)_7day_PBMCs_rNAPc2treated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.254996 ZBTB33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66627 CCR4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00586788 ACHE LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00569805 Lung squamous cell carcinoma_LUSC_TCGA-33-6737-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.3854 BRD-K50140147_CT-TAE684_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DDAH1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00538324 colonic cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.538604 Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null colon TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 LCN10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07215 colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.65763 colonic mucosa TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ISCU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38008 NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03555 BRD-A31107743_89671_HT115_6.0_h_0.09_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CBL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00482122 PMC8567280-EMBR-22-e53014-s008.xlsx-PC3_TIP5_bound_promoter-Unnamed_4_BAZ2A Rummagene Transcription Factor Associations 2026 1.0 null CRCGN014_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1098 RAB5IF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09202 intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.361527 EB1 CCLE Cell Line Gene Expression Profiles 1.0 1.41857 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5878-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MALL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23462 Ebolavirus(ZEBOV)_6day_PBMCs_rhAPCtreated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.015356 PPP1R14B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00757196 NFIL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57125 SHP77 CCLE Cell Line Gene CNV Profiles -1.0 -1.87455 GPRIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70503 PHTF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00954871 ZNF396 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75907 Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K82249895 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43382 NIBAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21541 CRCGN010_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.51904 BRD-K95858622_NCGC00182609-01_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K19516614 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.98199 Central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 enlarged lymph nodes MGI Mouse Phenotype Associations 2023 1.0 null APOC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00822308 TRMT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49529 Rectum adenocarcinoma_READ_TCGA-AF-5654-11A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00299961 BRD-K01436366_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K84054400 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0187 ZNF850 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75507 BRD-K04853698_-666_SW480_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prostate adenocarcinoma_PRAD_TCGA-V1-A8MU-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K64860662 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57176 BRD-K67177501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18395 TRIM62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36938 PRSS23 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00396001 RRAGA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36172 CD55 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27008 ELAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57512 SNU-638 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.35865 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.974812 BRD-K69393995 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13462 hsa-miR-450b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 ALDOC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57803 integral component of membrane GO Cellular Component Annotations 2015 1.0 null CREB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25598 BRD-K64890080_BI 2536_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-3653 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.50823 CRCGN015_HEPG2_48H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.90203 SNAI3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15502 HNRNPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69445 BRD-K02793474 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47649 BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.71204 PACSIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15032 DEXI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21949 FTO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49873 CAPNS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05712 15902281-TableS1b GeneSigDB Published Gene Signatures 1.0 null ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.587584 BRD-K40809590 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25147 BRD-K72661036 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35297 gated channel activity GO Molecular Function Annotations 2015 1.0 null CAMA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.68804 POLR3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7805 H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04327 SH3BGRL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54596 FAM110C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00903 Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83V-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stage, Colon Cancer DisGeNET Gene-Phenotype Associations 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null PAGE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45006 PCID2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00523023 DNAJB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4087 BRD-K52654243 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.084 UGT3A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4249 MYRFL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.0212 BRD-A20697603_T8902_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EMC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2273 NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.29556 HNRNPA1L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23944 BRD-K29200961 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3601 ISG20L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32056 GNAI2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00426659 DMRTC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 5.10364 MELHO CCLE Cell Line Gene CNV Profiles -1.0 -1.41446 MGAT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03324 CRCGN015_MCF10A.TP53.M_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.19835 GSE160817_7_v_1_slamf6_human RummaGEO Gene Perturbation Signatures -1.0 null MTG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26628 BRD-K89584810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90035 GOLM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.63233 HCC33 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51043 GSE68156_0_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null IRF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.6291 Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 169.656 SOX8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.4124 SEC14L4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00587511 CRCGN011_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.0613 ICAM5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00808591 Perturb_13599_KO_HDGFL2_SRP153901 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.86618 PSIP1_Deficiency_GDS2883_633_human_T-cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11607 BRD-K02822062_CT-200783_NCIH1694_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5507-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1648 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03553 GSE139948_3_v_6_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.907928 CBS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00460428 EIF3D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56231 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3471-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Organellar large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.181 ZNF625 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35277 striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.43263 CRCGN017_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.4477 BRD-K55070890_thiothixene_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ASIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0026 PIP5KL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00767 BRD-K21729626 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.07298 TNKS_INHIBITION_GDS5029_280_human_SW480 KRAS-mutant colorectal cancer cell line - 4hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K56653679_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HL60 BioGPS Cell Line Gene Expression Profiles 1.0 1.89634 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11075 BRD-K50140147_HY-10192_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ADAM11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69176 TEAD4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00737413 ADH1C LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00666241 FOSL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00535143 ZNF418 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27082 U20S BioGPS Cell Line Gene Expression Profiles 1.0 1.34341 CRCGN012_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.26885 cation channel activity GO Molecular Function Annotations 2015 1.0 null VARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70785 BRD-A41250203_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null APOLD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00765978 SF539 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12299 ESRP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62265 GPRC5A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00403576 KDM4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7052 CRCGN015_HEPG2_48H:G06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.60763 BRD-K47983010_BX-795_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN012_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.56402 PKN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66674 PANC 03.27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.974812 PMAIP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00566413 GSE144231_4_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZSCAN21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.0296 passive transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null colon GeneRIF Biological Term Annotations 1.0 null Hoxa13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.5858 HELZ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34404 CXXC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17286 BRD-K49005954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.98147 BRD-A36630025_-666_JHUEM2_6.0_h_0.35_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null C80 DepMap CRISPR Gene Dependency 1.0 4.02578 NSDHL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00378244 BRD-K56343971_HY-10247_HT29_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN008_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8349 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8098-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FGFBP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00471411 SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.860895 ZNF366 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58351 CRP LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00510534 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23351 BRD-K82795137_Loratadine_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26645 bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.233567 FNDC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.40688 HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null fallopian tube GTEx Tissue Gene Expression Profiles 1.0 1.16644 ANKRD23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27075 ATP5PO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76476 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN016_MCF10A.TP53.M_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.968 LRP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97296 posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15149 KCND2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00606181 layer IIIb of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2076 YH13 CCLE Cell Line Gene Expression Profiles -1.0 -2.35056 LTK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00641247 striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.977207 BRD-K14821540_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K21996189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44223 FOXA1 JASPAR Predicted Transcription Factor Targets 1.0 null G122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2121 BRD-K07303502_Arachidonyl trifluoro-methyl ketone_RKO_6.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN013_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.65615 KLE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.890221 BRD-K34604755 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11228 laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.05493 ESS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90323 BCOR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.6993 Prostate adenocarcinoma_PRAD_TCGA-CH-5794-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SEMA4B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.22196 orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.88488 epithelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073412 UFSP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44247 PARP15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25395 MAFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48764 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFF ENCODE Transcription Factor Targets 1.0 null viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.093023 GATA1::TAL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0123 PDXDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5207 OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16208 COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.903174 BRD-K26087938 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26244 BRD-K82971429_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN016_MCF10A.WT.HP_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.22385 TMEM185A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60615 TCF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.0705 GPR146 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0064412 MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null ONECUT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 103.725 CHTF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76378 Pyloric cecum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.519 KU-19-19 GDSC Cell Line Gene Expression Profiles 1.0 3.5353 PIP5KL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00560231 BRD-K27109474 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35993 BRD-K33539506 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36364 EMC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06839 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SUGP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13101 NIPAL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86076 H3-4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73527 ZNF236 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29257 CTNS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72746 CRCGN008_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8185 G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.987633 BRD-K01757377 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.76795 Acute Myeloid Leukemia_LAML_TCGA-AB-2849-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IGFBPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43765 EPHA10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00681071 PAX5 ENCODE Transcription Factor Targets 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null RPS27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03212 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.89774 SCMH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01781 EVX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94143 CFAP298 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50696 FAM219A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10645 BRD-K54687541_3-isobutyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LSM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46751 OIP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.89985 T3M3 DepMap CRISPR Gene Dependency 1.0 6.55537 ERF::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.1295 BRD-K93754473_-666_SW948_6.0_h_28.39_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K91701654_70970_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RCOR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8304 BRD-K56351525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28619 SLC30A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04316 hsa-miR-548d-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 20670856-Table2 GeneSigDB Published Gene Signatures 1.0 null Mucinous adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.116 CRCGN016_MCF10A.WT.HP_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.18249 RPS28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17592 CEP89 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00573769 Colonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.781 BRD-K06330738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27928 TMEM223 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76313 MAST3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37231 colonic adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.592043 GLIPR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87384 GTF2E2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58853 BRD-U43867373_-666_HEPG2_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IGR1 CCLE Cell Line Gene CNV Profiles -1.0 -1.55954 ANKRD33B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.60958 NDUFS6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00846812 BRD-K07388954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49975 CiliaryGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.96598 Small intestine epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.573 large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.657234 GAS6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00669306 BRD-K72561299 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12365 POMGNT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91306 KRT17 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0050477 Colon carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.326 CRCGN015_MCF10A_48H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.37079 COQ6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9681 BRD-K25269762 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04059 ATP6V0B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54774 NR2F2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NPM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88296 MRPS28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39965 HS571T CCLE Cell Line Gene Expression Profiles 1.0 1.55173 BRD-K36743230 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00799 MDAMB175VII CCLE Cell Line Gene CNV Profiles -1.0 -1.76396 MFSD13A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00672859 BRD-K05074020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39612 BRD-K52047843 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57596 SRCAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54436 ARH77 DepMap CRISPR Gene Dependency 1.0 3.77277 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7886-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 19399471-Table1 GeneSigDB Published Gene Signatures 1.0 null CRCGN008_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.43465 CRCGN016_MCF10A.TP53.M_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.63107 PKDCC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00503239 BRD-K83218047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08336 CRCGN010_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33167 RCOR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84112 FOXP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.9127 BRD-K68008192 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.00141 hippocampus (hippocampal formation)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.872315 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040091 RPA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.75851 BRD-A58564983_SELAMECTIN_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KU1919 CCLE Cell Line Gene CNV Profiles -1.0 -1.48969 HNRNPAB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00698539 rna GeneRIF Biological Term Annotations 1.0 null BRD-K88868628_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IRF3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00501092 TFAP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.2271 SW-48 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.795 CRCGN017_MCF10A.TP53.M_24H:G11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.15929 PMC3470785-NIHMS377161-supplement-12.pdf-421-PRDM5_PRDM5 Rummagene Transcription Factor Associations 2026 1.0 null KLK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85734 BRD-K45503385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.34335 BRD-K50388907_FENOFIBRATE_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K41853443 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11562 BRD-K17474512 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27445 indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.982101 BRD-K24132293_piperlongumine (HPLC)_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.WT.HP_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.2363 APRT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54022 ion channel activity GO Molecular Function Annotations 2015 1.0 null MYBL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79108 RALY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41812 adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.2559 SAA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00669538 Lateral ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ZNF384 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 285.908 BRD-K47326075 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06019 stratum pyramidale of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.94178 BRD-K75976016 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15777 CRCGN015_HEPG2_48H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.51542 Lef1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.4921 TRMT61A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79567 MCFD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82258 PIGU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48871 Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.896965 TPM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62728 FAAP24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92357 layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07817 FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.3887 SG in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14277 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JP-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040788 DYRK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00516993 NPRL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3863 CMTM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39448 HTR1E LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00658927 NCIH322 CCLE Cell Line Gene Expression Profiles 1.0 1.7362 BRD-K75036062 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08556 OBSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40225 GUCY2D LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0075792 HDAC5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00459244 PPP2R3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.81472 BICR78 DepMap CRISPR Gene Dependency 1.0 15.4408 ZIC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12611 BRD-K97410356 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.41882 GAMT LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00705041 BRD-A68930007_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ATF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43921 metal ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null smallintestine BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 BRD-K96799727_Pifithrin- ?_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FAAH2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00518691 CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.88914 CRCGN015_HEPG2_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.32253 SKMEL2 CCLE Cell Line Gene CNV Profiles -1.0 -1.99688 BRK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08346 ZNF558 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 169.092 IZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.43481 TRAPPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52696 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E6-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAB3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58543 POU2F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72606 Brain Lower Grade Glioma_LGG_TCGA-DB-A75L-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ion transport GO Biological Process Annotations 2015 1.0 null YH-13 GDSC Cell Line Gene Expression Profiles 1.0 1.75811 EFR3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93849 CRCGN016_MCF10A.TP53.M_24H:L11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.89735 ADAM8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00841993 PCED1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70995 Esophagus - Mucosa GTEx Tissue Gene Expression Profiles 2023 1.0 7.21186 BRD-K71109636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11918 ADARB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00669284 fertilizedegg BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.888672 RPS6KA5 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00682296 BRD-K19492738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1583 HUH-6-CLONE5 COSMIC Cell Line Gene Mutation Profiles 1.0 null G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05808 BRD-K57080016_-666_RKO_6.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MFE296 DepMap CRISPR Gene Dependency 1.0 3.37498 PLEKHB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61111 CRCGN015_HEPG2_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.80707 GSE148692,GSE148695_7_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null NMRK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09183 apical part of cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.171149 ms4a12 GeneRIF Biological Term Annotations 1.0 null GRAMD2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00526154 YMB1 CCLE Cell Line Gene CNV Profiles -1.0 -1.61604 BRD-K45223163 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02391 molecular_function GO Molecular Function Annotations 2015 1.0 null Colorectal carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.252 BRD-K03855997 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41127 ACACA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27565 BRD-K24132293_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null essentially GeneRIF Biological Term Annotations 1.0 null KU812 CCLE Cell Line Gene CNV Profiles 1.0 1.33059 Arid3a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.2222 TPD52L3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00433373 YAPC CCLE Cell Line Gene CNV Profiles -1.0 -1.40234 BRD-K27841704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25643 Nfe2l2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.5785 BRD-K43992612 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09122 MSL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07834 HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.10589 hsa-miR-494 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 CRCGN015_HEPG2_48H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35438 BRD-K41700289 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37735 Perturb_3804_KO_Cftr_SRP067491 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.29669 NCIH2073 CCLE Cell Line Gene CNV Profiles -1.0 -2.16335 CRCGN013_HEPG2_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.49143 RPMI-7951 GDSC Cell Line Gene Expression Profiles -1.0 -1.4251 SLC6A8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00646251 TMEM104 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80653 ADGRG5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79734 SP1 ENCODE Transcription Factor Targets 1.0 null CRCGN015_MCF10A_48H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.93395 DCAF16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75728 CCDC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17062 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042644 CRCGN016_MCF10A.TP53.M_24H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.78739 SOX12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26664 CORT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08633 Premature aging_Skin fibroblast_GSE10123 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.36791 calcium ion transmembrane transport GO Biological Process Annotations 2015 1.0 null HPN LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00916391 GSE199606_3_v_0_csf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44617 STRN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57663 BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SLC25A45 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92729 BBX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43136 WSUDLCL2 CCLE Cell Line Gene Expression Profiles 1.0 1.60358 BRD-A11154023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13832 PATL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00550411 transporter activity GO Molecular Function Annotations 2015 1.0 null DHRS3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00934117 BRD-K26786741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11865 FAM133B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71279 BRD-K17610834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08935 DLC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86544 CD8+_Tcells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.40462 WIPF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00550867 LSM8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12476 dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.68732 protein binding GO Molecular Function Annotations 2015 1.0 null BRD-K72783841_AG 555_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PGD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98568 496100370_PCx_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 9.94203 BEST4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72096 PGM2L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48571 ZNF175 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30722 BRD-K88317944_VU0420364-1_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CYP19A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00562046 Limbic system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ALDH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85758 primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04628 viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ZBTB32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50521 Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z6-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MLF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86597 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 PHYH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00449326 BRD-K70428675 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00663 CRCGN009_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.015 ventrolateral prefrontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08165 BRD-K81206010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31336 WDR91 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.56371 CHGB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24325 RAG2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00792141 TWIST1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00791334 GSE148695,GSE167284_2_v_1_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BOLA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19253 PLEKHB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48207 NUGGC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00763437 WBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29991 SP1 JASPAR Predicted Transcription Factor Targets 1.0 null NR1I3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2367 COLO678 CCLE Cell Line Gene CNV Profiles -1.0 -2.12358 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PRKACB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00607776 ZNF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.9126 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.49207 RBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87148 HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.9393 CRCGN008_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.2572 localization GO Biological Process Annotations 2015 1.0 null PRKAR1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3285 primary motor cortex (area M1, area 4)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13354 BRD-K50133846 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51497 SKIC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.79275 19399471-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null SUZ12 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00364187 CRCGN015_HEPG2_48H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.79903 IL18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21692 HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 75.2317 RXRB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57637 XRCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40648 FXYD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27057 GSE254848_9_v_8_ptges_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTHRC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39933 ULK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67725 BRD-K33017576 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2161 Cerebral cortex TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 OLFML2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.90726 chr11_60499584_G_T_b38 GTEx eQTL 2025 1.0 2.35455 SLC16A14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51562 Basal plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.761 FOXK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.2415 BRD-K61522760 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07715 SZ in subgenual cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.960891 Enterocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.582 SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K38574421 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11613 CRCGN014_HEPG2_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.41547 GATA3-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN008_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.05255 CA6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00388552 T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.51587 DAUDI CCLE Cell Line Gene Expression Profiles 1.0 1.79658 RB1_KD_GSE50532_657_human_OSTEOBLASTS GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ES4 DepMap CRISPR Gene Dependency 1.0 2.33463 KIAA1671 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73023 GSE165122_2_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K51370144 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99383 ZMYM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.43939 Glucosidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.062 CEACAM21 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00859908 SW948 GDSC Cell Line Gene Expression Profiles -1.0 -1.58688 Myelomonocytic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.595 BRD-K16158586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23064 PSIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66538 heart BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.92107 SRSF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5768 BRD-K09436313_P5172_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hsa-miR-548c-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 ALK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00616465 FEZ1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0051993 CRCGN009_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.39976 PRPF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28571 PRKAR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80875 stratum pyramidale of rostral CA2 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17345 GSE165122_2_v_3_metformin_mouse RummaGEO Drug Perturbation Signatures -1.0 null AIFM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54051 GSS CCLE Cell Line Gene CNV Profiles 1.0 1.42685 YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.4272 SLCO1A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0058443 FAM229B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75984 EIF3H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00877 HSPG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3176 CRCGN015_MCF10A_48H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1366 interference GeneRIF Biological Term Annotations 1.0 null Cerebral hemisphere TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BRD-K88510285_B675700.cdx_HT29_24.0_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCIH2052 CCLE Cell Line Gene CNV Profiles 1.0 1.43987 ERLIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90523 MLX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30642 CRCGN012_HEPG2_24H:J19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5484 IZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.914999 KYSE-510 COSMIC Cell Line Gene Mutation Profiles 1.0 null KIR2DL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00811675 HCT15 BioGPS Cell Line Gene Expression Profiles 1.0 0.970409 BRD-K18190982_COT-10b_JHUEM2_6.0_h_44.4_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null large intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 ST6GALNAC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0048968 Vermiform appendix TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.847 lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.953445 MFH-ino GDSC Cell Line Gene Expression Profiles 1.0 2.55791 BRD-K49371609_528116.cdx_MCF7_6.0_h_0.09_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CDX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.6899 CRCGN014_HEPG2_24H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5237 SETD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.97153 GSE222758_0_v_2_clofazimine_human RummaGEO Drug Perturbation Signatures -1.0 null RNF146 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71855 BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NUMA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53373 CDH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.755 BRD-K97617600 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.87722 GFI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7501 PMC6529539-41598_2019_43492_MOESM3_ESM.xls-Table_S2b-Table_S2b_Normlaised_log2_data_of_OriGene_and_Montpellier_samples_profiled_using_the_modified_protocol_Normalised_to_HKs_RPL13a_PPIA_ZNF384_ZNF384 Rummagene Transcription Factor Associations 2026 1.0 null PLEKHO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64746 BRD-K88378636_withaferin-a_HA1E_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Sensory dendrite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.776 BTN3A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00620966 BRD-K06148621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02221 DDX51 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06556 BRD-A30758703 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04362 C6orf120 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39932 ITGA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03441 BRD-K19712135 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70988 PANC1 CCLE Cell Line Gene Expression Profiles 1.0 1.50566 CHAGOK1 CCLE Cell Line Gene Expression Profiles 1.0 1.39884 CRCGN008_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80765 Rectum adenocarcinoma_READ_TCGA-AG-3731-11A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COQ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27846 USP27X CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62236 CD63 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00682847 CRCGN011_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.85715 BRD-K82362034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08533 DMRT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83248 GSE133683_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2 Rummagene Transcription Factor Associations 2026 1.0 null striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.24882 TMEM92 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7817 EME1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06658 CRCGN014_HEPG2_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14093 inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.9967 Colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.856 SNU182 CCLE Cell Line Gene Expression Profiles 1.0 2.05087 CALHM6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.44369 NPW CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42283 GZMK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00624796 posteroventral (inferior) parietal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.24831 subgranular zone of caudal dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46145 Colon transversum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.846 MRPL58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70361 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.890221 BRD-U51024685_HG-6-64-01_SKBR3_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null chr11_60502570_A_T_b38 GTEx eQTL 2025 1.0 4.54378 ZNF502 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71715 T-84 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.352 496100418_TCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.6035 BRD-K06543683_-666_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null A498 CCLE Cell Line Gene CNV Profiles -1.0 -1.50961 HAND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35932 tilmicosin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47467 RERFLCKJ CCLE Cell Line Gene Expression Profiles 1.0 1.49249 MAF::NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9202 TBX21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55736 MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37476 G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1426 SGTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36451 CRCGN011_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.46605 TSC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00699581 GSE196104,GSE196106_2_v_1_vsx2_mouse RummaGEO Gene Perturbation Signatures 1.0 null colorectal cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.572018 UNC119B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85074 CEACAM8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00432262 Dux JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.7652 CXCR2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00525015 BRD-K43558307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41479 Hyaline layer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.09 GCT COSMIC Cell Line Gene Mutation Profiles 1.0 null lateral hypothalamic area, tuberal part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.845705 BRD-A39093044_K784-3187_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6TV-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K97081185 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54994 TIPIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45584 PHACTR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21803 transport GO Biological Process Annotations 2015 1.0 null B3GAT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00629296 HT-29-MTX cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.858 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6QZ-01A-12R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATP2A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00482317 RNF122 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01127 600MPE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.957369 Sarcoma_SARC_TCGA-DX-A8BS-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE133213_6_v_15_znrf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null cdx2 GeneRIF Biological Term Annotations 1.0 null gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.49274 CRIP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00523024 Msgn1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.9557 BRD-K56196992_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null medial portion of STH Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.33971 calcium GeneRIF Biological Term Annotations 1.0 null MEF2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.3237 ZNF433 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.44264 PTPN13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98953 CPNE7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00624934 BRD-K44432556_-666_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TNRC6C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42013 Bloom Syndrome DisGeNET Gene-Disease Associations 1.0 null BAIAP2L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24989 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FABP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78243 Colorectum TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ST6GAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38403 PRSS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00533042 Intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.853 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RT-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Apical lamina of hyaline layer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.821 TRIM61 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52862 TTI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3441 PIP5K1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68956 BRD-K87947369_VX-680_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.074385 small intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ZIC5_01_284 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59992 ZNF611 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27981 CRCGN015_HEPG2_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.09735 large intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K72060858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43287 BRD-K54554531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01035 ETV6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5369 Sox1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.2802 FBXW9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64366 nucleus subputaminalis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03945 KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.974812 TNFRSF18 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00625054 BRD-K98529522 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56931 GSE147056_3_v_1_actl6b_mouse RummaGEO Gene Perturbation Signatures -1.0 null PLP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56899 BRD-K74291148 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.78969 MAG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0054005 PPARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4888 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JMJD6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00448698 BRD-K71737889 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70478 ATRX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56027 MOCS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43707 NO10 DepMap CRISPR Gene Dependency 1.0 5.15875 LDHC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00693152 BRD-K90133770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46143 ARMCX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72007 RERFLCAI CCLE Cell Line Gene Expression Profiles 1.0 1.47299 Anterior midgut TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.522 GSE213442_1_v_0_kpna2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K80890401 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57463 ZSWIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41537 APIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73086 colonic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.538209 BRD-K67075780_TGX-115_WSUDLCL2_6.0_h_160.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.WT.HP_24H:K22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9383 BRD-K60623809_SU11652_COV644_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TMEM63B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6275 ATP8B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61696 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.07577 STBD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78429 IZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.25796 store-operated calcium channel activity GO Molecular Function Annotations 2015 1.0 null BRD-K17705806_JTC 801_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POPDC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00548521 superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34509 PPP1R1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00795174 COPG1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00803036 PMC4060771-170289.f1.pdf-597-PEG3_PEG3 Rummagene Transcription Factor Associations 2026 1.0 null EME2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54334 TMEM89 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00724627 TRPV3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00534338 RIC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.19821 BRCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24036 MORF4L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40666 SHSYSY+RA BioGPS Cell Line Gene Expression Profiles -1.0 -2.62335 SRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69066 Microvillus membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.128 BRD-A03684405 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21811 LN340 CCLE Cell Line Gene Expression Profiles -1.0 -2.8828 BRD-K68313733_T5323840_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null UTP11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0043486 BRD-A15131297_Benazepril hydrochloride_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H2BC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10194 OAS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00617769 MEF2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 76.8434 divalent inorganic cation transport GO Biological Process Annotations 2015 1.0 null COLO 678 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.10531 BRD-K54233340_Dorsomorphin dihydrochloride_A375_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PDE4B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00446904 FOXP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.1488 TRMT13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24779 anterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.53336 BRD-K56345641 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12103 primary auditory cortex (core)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.05857 BRD-K94144010_(-)-cotinine_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K14961381 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16623 CDC42SE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33897 presence GeneRIF Biological Term Annotations 1.0 null PLA2R1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00548919 HES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12083 immunoprecipitation GeneRIF Biological Term Annotations 1.0 null NCIH82 DepMap CRISPR Gene Dependency 1.0 2.23661 SOX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.99377 IZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.932944 DESI1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00628376 CPXM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8771 SLFN13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71959 KCNQ2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00640434 ENSA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95037 IRF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.3816 HSD17B4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00565646 MTARC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40776 ANP32D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11712 PRKAG2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00546385 15208663-SuppTable1b GeneSigDB Published Gene Signatures 1.0 null TRAPPC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20013 CBP-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Colon sigmoideum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.6 SMIM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05241 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NEMF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9128 GATD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04696 MLLT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68751 CDC5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63376 hsa-miR-548h TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 SCRT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3972 divalent metal ion transport GO Biological Process Annotations 2015 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A76O-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VAMP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38192 BRD-K05549170_-666_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.890516 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SLAMF6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00774933 BRD-K78976513 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.85249 BRD-K99763083 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01235 RCC4 CCLE Cell Line Gene Expression Profiles -1.0 -1.63832 AN3-CA COSMIC Cell Line Gene Mutation Profiles 1.0 null EMILIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85458 BRD-K31542390_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4637-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane part GO Cellular Component Annotations 2015 1.0 null substantia nigra, compact part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.950278 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5402-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DPH5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73922 GSE145311_0_v_3_glutathione_mouse RummaGEO Drug Perturbation Signatures -1.0 null ZHX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77541 SPAG9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60593 CRCGN014_HEPG2_24H:H21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.02669 RORA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2472 THRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83834 Pituitary BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.929003 KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.51765 GSE112860_5_v_4_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN017_MCF10A.TP53.M_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3748 ARL4D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95341 LU65 CCLE Cell Line Gene Expression Profiles -1.0 -1.46131 RUNX1T1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00597068 CRCGN015_HEPG2_48H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.05278 HS729 CCLE Cell Line Gene Expression Profiles 1.0 1.73139 NB17 GDSC Cell Line Gene Expression Profiles 1.0 1.57414 CRCGN017_MCF10A.WT.HP_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.6831 hsa-miR-1202 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 Colon ascendens TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.647 PLCL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0062494 NKX2-3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00546525 ACHN BioGPS Cell Line Gene Expression Profiles -1.0 -1.48014 CRLF2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00718367 BRMS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03401 DSEL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.63828 NANP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0558 KCNC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08389 hsa-miR-4517 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GPR22 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00708208 Brain TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 496100419_TCx_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.21382 UBXN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06424 BRD-K04853698_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE164494_1_v_2_rab22a_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-548n TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 CRCGN012_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5814 STAT1 JASPAR Predicted Transcription Factor Targets 1.0 null ROCK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00786025 RSPO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61179 FOXG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.5525 POU1F1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00554732 ALCAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56592 ZR751 CCLE Cell Line Gene Expression Profiles -1.0 -2.14342 PBX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29535 BRD-K46815185 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05144 RUSC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3203 colon HPA Tissue Gene Expression Profiles 1.0 1.43038 ASB16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58364 BRD-K97472167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30472 CXCL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90531 BRD-K92093830_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MRPS16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86232 CRCGN013_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.82595 CRCGN012_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.47703 BRD-K53423944_6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine-2,4(1H,3H)-dione_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null STAT3 MotifMap Predicted Transcription Factor Targets 1.0 null CRCGN015_HEPG2_48H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.87703 BRD-K88278225_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K47348275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08711 MNT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39309 intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.654067 APOBEC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22205 CRCGN015_HEPG2_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.92985 BRD-K59207957 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77458 MROH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79293 TYMS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00395592 JHH5 CCLE Cell Line Gene CNV Profiles 1.0 2.25067 FCER1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0062751 small intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.119763 outer CP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.98099 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YW-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rectum HPA Tissue Gene Expression Profiles 1.0 1.48559 GSE81803,GSE81912_4_v_5_fmr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.38577 KATNBL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37009 PTK6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00598534 CA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84846 VNN1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00497197 KCNA6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00702861 colonic epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.997601 SMAD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07061 hsa-miR-412 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 ARL4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62396 SPATA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04915 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043773 BRD-K36007650_Puromycin dihydrochloride_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.37476 Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 WDR20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11898 BRD-K02822062_CT-200783_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EWS502 CCLE Cell Line Gene Expression Profiles -1.0 -1.60838 COX6B1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00692752 NCIH1184 CCLE Cell Line Gene Expression Profiles -1.0 -2.04392 PGAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13476 CRCGN008_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7691 membrane LOCATE Predicted Protein Localization Annotations 1.0 null BRD-A69196860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2151 Supramarginal gyrus volume GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.504576 BT474 CCLE Cell Line Gene CNV Profiles 1.0 1.71883 hsa-miR-151-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV1-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.87173 BRD-K17953061_-666_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2121 SEMA7A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00536586 TMEM191B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16763 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.564 viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 Brain Lower Grade Glioma_LGG_TCGA-VM-A8C8-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K13564884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03532 UTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.354 MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.51765 TRDMT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00528802 BRD-K78867378_mw-A1-12_NCIH1694_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BCL2L10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84519 SF539 BioGPS Cell Line Gene Expression Profiles -1.0 -1.04805 HMGCR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0052413 BRD-K15378071 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26901 BRD-K72238567_656402-250MG_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ATG9A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35346 TMEM132A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03078 TSPOAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52812 sw-48 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.33364 CTDP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15524 BRD-K01877528_TL_HRAS26_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOXD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27199 BRD-K10435664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15632 GSE77795_2_v_1_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF619 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05471 HAPLN3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00528617 BRD-K00615600_AG14361_NCIH1694_6.0_h_25.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NR2C1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0055016 promoting GeneRIF Biological Term Annotations 1.0 null BRD-K74148702_curcumin_THP1_6.0_h_48.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CD209 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00685859 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.45 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03632 CECR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3075 intestinal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.527139 appendix HPA Tissue Gene Expression Profiles 1.0 0.90427 XPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30082 EIF2B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02647 colorectum TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 PCI6A DepMap CRISPR Gene Dependency 1.0 3.86054 PKN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.35072 BRD-K47890395 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23554 ITGB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43173 H2BC18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38286 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Atoh1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.8937 KYAE1 DepMap CRISPR Gene Dependency 1.0 3.93072 RELB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26707 mammarygland.lact. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 CRCGN017_MCF10A.WT.HP_24H:A21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1101 primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.854463 colorectal cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.180509 TP63_01_196 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.5884 SHMT1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00879199 BRD-K29438074 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04488 PMC4051124-1471-2164-15-256-S16.XLSX-WES_IPD-RBCK1_2-Target_RBCK1 Rummagene Transcription Factor Associations 2026 1.0 null TUBA4A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00575414 GSE191015_1_v_3_gsdmb_human RummaGEO Gene Perturbation Signatures -1.0 null PMC11554977-40199_2024_523_MOESM2_ESM.xlsx-Sheet1-Supplement_2_Metformin_Drug_Sensitivity_and_Damaging_Mutation_by_using_PRISM_Repurposing_Primary_Screen_and_Damaging_Mutation_in_DepMap_PRDM6 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K54100199 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00069 TCTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85352 ATP6V1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00672332 SF295 CCLE Cell Line Gene CNV Profiles -1.0 -1.62364 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A216-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOXD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.12742 BRD-A06840811 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2542 SLC36A2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00660835 CRCGN009_HEPG2_24H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.6913 PARK7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83236 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25401 SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10743 KLF5 JASPAR Predicted Transcription Factor Targets 1.0 null NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26052 DCTN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72191 BRD-K05979026_NCGC00241726-01_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 KIFC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50637 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0227 CDY2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38569 FAM111A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70804 CRCGN015_MCF10A.WT.HP_24H:F16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.26595 SDHAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79703 DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.9393 PLEKHF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9401 ITGB1BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99918 DNASE1L3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00845325 RAB43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01214 laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00355 CASP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0083433 TMEM185B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.48022 Cell type benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.209 TMEM54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7054 BRD-K03662481 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69642 CASK LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00740575 ventral tegmental area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.40507 CRCGN015_MCF10A_48H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01923 COV318 DepMap CRISPR Gene Dependency 1.0 2.70029 KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.95346 NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04327 4-PPBP LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.72219 ETV7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2132 BRD-K54233340_Dorsomorphin dihydrochloride_SW948_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SUM185PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.773643 DHODH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00585578 AP2S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4929 TP53-16413492-HCT116-human ChEA Transcription Factor Binding Site Profiles 1.0 null single-organism transport GO Biological Process Annotations 2015 1.0 null BRD-K86086888 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25837 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.72052 SEC24A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87207 hsa-miR-548y TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 NUGC3 CCLE Cell Line Gene Expression Profiles 1.0 1.35468 CRCGN015_MCF10A.WT.HP_24H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.6015 SMAD2/3-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null EDNRA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0073529 Head TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BRD-K98824517_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Hoxd13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.9679 SYT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89905 SMPDL3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8931 TE5 CCLE Cell Line Gene CNV Profiles 1.0 2.86737 hsa-miR-641 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 BRD-K83058591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23539 BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.748058 BRD-K92093830_doxorubicin_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HMGN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54632 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.890516 G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.9393 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A820-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K91813753 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77624 IKZF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68904 channel activity GO Molecular Function Annotations 2015 1.0 null gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ACMSD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00715852 HS936T CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 Apical plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.143 KP-N-YN GDSC Cell Line Gene Expression Profiles -1.0 -1.61276 endogenous GeneRIF Biological Term Annotations 1.0 null PDSS2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00978613 CYP2A13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7242 Zymogen granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.269 FOXP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.8746 malignant GeneRIF Biological Term Annotations 1.0 null CFAP68 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57331 AMH LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00759242 HSD17B6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00780674 SRM LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00725364 COQ10B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01904 Brain Lower Grade Glioma_LGG_TCGA-VV-A829-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRR7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88194 PLTP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94477 TCF7L2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.3818 DDIT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85491 TE11 CCLE Cell Line Gene CNV Profiles 1.0 1.80263 KLHDC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32458 TBX18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80314 BRD-K00317371_-666_COV644_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ventrolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20894 17210682-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null BRD-A34806832_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null posteroventral (inferior) parietal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.921007 C3orf62 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79613 SPINK4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00642225 CRCGN015_MCF10A.TP53.M_24H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.10605 layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.091 CRCGN015_HEPG2_48H:L01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.60578 NOL7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50559 tongueepidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07245 SKI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56816 intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 superior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.967979 IRF2 JASPAR Predicted Transcription Factor Targets 1.0 null GSE248858_6_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null PCGF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87188 BRD-K88569143_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GJC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00600856 FOXK2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.9761 CRCGN009_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.56131 GSE200352_1_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null BDH1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00398053 FOXC1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 105.342 RAPH1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00692696 C1QBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92318 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.18891 WIPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23241 K-562 COSMIC Cell Line Gene Mutation Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057318 NCR3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00421737 WFS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3688 CJM CCLE Cell Line Gene CNV Profiles 1.0 1.42332 SK-MEL-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3132 NSD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00528838 E2A-27217539-CHIP-SEQ-RAMOS-CELL-LINE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K35945596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15865 Lung adenocarcinoma_LUAD_TCGA-05-5429-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC41A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0057585 calcium ion transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null PTGDR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00645835 PLEKHA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28474 S100PBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06672 inner SZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.834111 CRCP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81753 BICR10 DepMap CRISPR Gene Dependency 1.0 4.95635 CCT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42327 TLE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72953 BRD-K64800655_HY-11001_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN014_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7235 BRD-K20520611 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.92531 BRD-K54233340_Dorsomorphin dihydrochloride_HT29_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.2723 MRPS27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06858 KLLN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.617 BRD-K60107240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26394 SP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.4063 APBA2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00575626 ZBTB12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6516 A1CF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82003 colon cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.856087 CRCGN012_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35602 ZNG1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33167 IFI6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00637105 gastrointestinal tract TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 MTRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33284 MCU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73707 SNU886 CCLE Cell Line Gene Expression Profiles -1.0 -1.5 CRCGN017_MCF10A.WT.HP_24H:C02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.09483 HS 936.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32786 PIK3AP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00839223 Prostate adenocarcinoma_PRAD_TCGA-KK-A59V-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ENC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31087 HHIPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85888 stratum pyramidale of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46654 ATP9A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0058554 MASTL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00657819 BRD-K04358482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22238 ZR751 CCLE Cell Line Gene CNV Profiles -1.0 -1.5928 IGR39 CCLE Cell Line Gene CNV Profiles 1.0 1.74947 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRKAG3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00698549 abnormal lymph node morphology IMPC Knockout Mouse Phenotypes 1.0 null CAL-120 GDSC Cell Line Gene Expression Profiles 1.0 1.64662 BRD-K24132293_piperlongumine (HPLC)_SW620_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CSNK2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22257 integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GSE101239_3_v_2_valproic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-548j TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 NAA20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35186 Colon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K64804596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10036 KIF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4568 JHH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05939 BRD-K78315404 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15846 rectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.179627 CYRIB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49384 FOXD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.85 STAT5A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00712966 ICC2 DepMap CRISPR Gene Dependency 1.0 2.11011 RIMKLB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82545 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07777 hsa-miR-216a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 SOX18 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4491 BRD-K47983010_BX-795_SNGM_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null phenyl-aminosalicylate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75243 PHOSPHO1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00556865 VPS35 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00492327 revealed GeneRIF Biological Term Annotations 1.0 null S462 DepMap CRISPR Gene Dependency 1.0 4.60863 NDUFA13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29155 colonocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.901998 NME6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90787 hsa-miR-3148 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03632 Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MOCOS LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00518432 GSE164494_1_v_2_angiotensin ii_mouse RummaGEO Drug Perturbation Signatures -1.0 null SW579 CCLE Cell Line Gene Expression Profiles -1.0 -1.77563 calcium ion transport GO Biological Process Annotations 2015 1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.591641 MARK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26855 BRD-K39411863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23951 BRD-A68009927_-666_ASC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Stat4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.4027 amygdaloid complex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01882 DCAF12L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12837 CRCGN015_HEPG2_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.50061 NOLC1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00552381 CRCGN009_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.54748 SMG6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50819 MYO18A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34277 BRD-K01847595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1287 KATNA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04134 striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.44488 CRCGN009_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.01112 orbital frontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04172 BRD-K59184148_SB-216763_PC3_24_h_0.04_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PANC0813 CCLE Cell Line Gene CNV Profiles 1.0 1.52014 TRPC4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00541355 G292CLONEA141B1 CCLE Cell Line Gene CNV Profiles 1.0 1.44197 TMEM216 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66677 KLE CCLE Cell Line Gene Expression Profiles 1.0 2.40871 BTNL10P LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00653677 SH3PXD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45031 amygdaloid complex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.837761 chrysophanic-acid LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39717 crypt TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.20387 RNASE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33372 PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null C1QA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00600293 ZPR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38051 CRCGN017_MCF10A.TP53.M_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.83752 MAFK ENCODE Transcription Factor Targets 1.0 null CA5B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00644098 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.22819 Benign neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.195 BRD-A09349126_NORETHINDRONE ACETATE_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hippocampus (hippocampal formation)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22842 NUDT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95203 NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.47186 EPB41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46212 ZBTB34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23079 SHISA2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00517531 ZNF587B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46631 CCNI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58838 inorganic cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null BRD-A45607610 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07177 IFI30 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00561843 CRCGN017_MCF10A.WT.HP_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.37175 HSPBAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23845 CRCGN011_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.43965 CALCOCO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3777 IZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.32461 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MU-A5YI-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.06828 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37549 PPARG JASPAR Predicted Transcription Factor Targets 1.0 null MTNR1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00940189 NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.903174 BRD-K42016545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05751 mucosa TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null colon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null WDR18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90108 MT-ND5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80248 BRD-A01593789_CHLORMADINONE ACETATE_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ETV2::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9946 colorectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.505102 FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null TNFSF13 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00486862 BRD-K15025317_Bay 11-7821_RKO_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ERI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.61342 PXYLP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.01719 RBL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.47228 Congenital heart disease (maternal effect) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.639794 BRD-K56563758 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39479 KARPAS-45 GDSC Cell Line Gene Expression Profiles 1.0 1.63911 FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K57926513_AC-1133_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-A26711594_NICARDIPINE HYDROCHLORIDE_NCIH1694_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hsa-miR-1910 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 BRD-K23713813 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09703 EGLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70663 CRCGN015_HEPG2_48H:M17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.97231 Colonocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.762 HT COSMIC Cell Line Gene Mutation Profiles 1.0 null HSD17B8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00670418 apical complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.175466 rostral presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.38466 TNP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00500745 BRD-K49371609_528116.cdx_SKM1_6.0_h_0.09_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTF2A1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25113 CORL105 CCLE Cell Line Gene CNV Profiles -1.0 -1.66292 DAUDI COSMIC Cell Line Gene Mutation Profiles 1.0 null VCAM1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00759747 E2F3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9941 A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_7Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.24818 BRD-K32536677_-666_SW948_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF607 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.45717 Integument TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K46936325 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66516 Appendix BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.39636 SPI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12206 Mesothelioma_MESO_TCGA-MQ-A4LV-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MRGPRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44295 CD19+_BCells(neg._sel.) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.21848 BRD-K80568112 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65296 CRCGN014_HEPG2_3H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17005 NCAN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70518 Colon adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.402 BRD-K02822062_CT-200783_COV644_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X0-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:A19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01398 BRD-K63887881 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75094 LN464 CCLE Cell Line Gene Expression Profiles -1.0 -1.93298 KDM2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00462739 KCNK10 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00589954 Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.752 NASP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28812 BRD-A18497530_EI-293_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SOX9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.1316 GSE133691_1_v_3_lgr5_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K49371609_528116.cdx_COV644_6.0_h_0.09_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null establishment of localization GO Biological Process Annotations 2015 1.0 null CRCGN015_MCF10A_48H:A07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.44044 amygdaloid complex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26448 RAPGEF6 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00638463 PAGR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95734 olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.60875 JMY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57921 BRD-K33272502_DG-041_SKMEL28_6.0_h_40.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TP53 JASPAR Predicted Transcription Factor Targets 1.0 null NCI-H650 COSMIC Cell Line Gene Mutation Profiles 1.0 null inorganic ion transmembrane transport GO Biological Process Annotations 2015 1.0 null YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51043 BRD-K81528515_HY-10159_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NEK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85331 SOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26396 Malignant Tumor Of Colon DisGeNET Gene-Disease Associations 1.0 null BRD-A98444709_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE114284_1_v_5_irf1_human RummaGEO Gene Perturbation Signatures 1.0 null FOXE1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 118.743 BRD-K69852452_7241-4207_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A50913845 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23312 PTPN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89636 TRIM46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14136 CRCGN017_MCF10A.WT.HP_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.34445 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BRD-K89399989 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43189 BRD-A19037878_trichostatin A_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CPT1B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00557366 SAR1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.113 SPATA33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65692 HCC1419 CCLE Cell Line Gene CNV Profiles -1.0 -2.59447 BRD-K99749624_S1003_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null UGT3A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00575352 CRCGN017_MCF10A.WT.HP_24H:N10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.59845 CRCGN011_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1424 adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.310059 FADD LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00457212 17210682-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null SCARF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13478 DNASE1L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70781 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-548a-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 BAIAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.12206 BRD-K50563598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09005 lateral hemisphere of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.936926 PHF20L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40485 BRD-K27584103 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61506 BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63266 hsa-miR-371-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 C1QC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00510472 CRCGN009_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.65438 SFXN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62874 Fc-epsilon receptor I complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.092 PWP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02116 Excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.64162 BRD-K06482871 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84009 BRD-K25180881 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03079 PXDNL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93826 transmembrane transport GO Biological Process Annotations 2015 1.0 null BRD-K08811598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1863 Zymogen granule membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.285 CRCGN017_MCF10A.TP53.M_24H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.59201 NUP50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85684 hsa-miR-548b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 increased circulating alanine transaminase level IMPC Knockout Mouse Phenotypes 1.0 null colon GTEx Tissue Gene Expression Profiles 1.0 2.18987 MICU2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81631 EEF1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72936 PTGS1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00516966 P2RY11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07334 CRCGN015_HEPG2_48H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.10776 channel GeneRIF Biological Term Annotations 1.0 null RAB23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30757 BRD-K19220233_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE160817_7_v_9_slamf6_human RummaGEO Gene Perturbation Signatures -1.0 null medial mammillary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.858847 MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.846985 SPDYE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38148 SK-MEL-24 GDSC Cell Line Gene Expression Profiles 1.0 1.44296 CCDC181 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00639216 BRD-K29003210_OSSK_647368_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN011_HEPG2_24H:L24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0957 BRD-K15935639_Z-Leu3-VS_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IDUA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00765842 CCDC28B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02859 SLC26A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18956 GRHL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.2013 Lung adenocarcinoma_LUAD_TCGA-50-5045-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCDC77 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3101 GSE214685_0_v_1_nsun2_human RummaGEO Gene Perturbation Signatures -1.0 null OUMS23 CCLE Cell Line Gene Expression Profiles -1.0 -1.54846 HCC1569 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.830155 PMC6529539-41598_2019_43492_MOESM5_ESM.xls-Table_S4a-Table_S4a_Normalised_log2_data_of_RETRO-C_FFPE_samples_profiled_using_the_standard_protocol_Normalised_to_HKs_RPL13a_PPIA_ZNF384_ZNF384 Rummagene Transcription Factor Associations 2026 1.0 null KCNIP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27456 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.890516 ETV2::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.1552 BRD-K34009110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29223 RIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33065 BRD-K52397688_Amperozide_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null ZBTB24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53074 ATL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41825 BRD-K00954209_7643453_VCAP_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.7765 BRD-A18763547_-666_A375_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DCLRE1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81953 GSE148695,GSE167281_2_v_1_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SAMD8 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00532518 tylosin-tartrate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53508 BRD-K25237268 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14056 JHH-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25076 A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_7Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.60852 CRCGN015_HEPG2_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.96102 UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03555 BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DOK DepMap CRISPR Gene Dependency 1.0 2.84849 Mafb JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.0225 BRD-K35429561 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26678 Crypt TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.442 BRD-K02822062_CT-200783_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE224969,GSE224971_3_v_5_chtop_mouse RummaGEO Gene Perturbation Signatures 1.0 null IRF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.3657 TWSG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50776 NAALADL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47151 ALX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97056 BRD-K87167435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20875 ASCL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82826 BRD-K00615600_AG14361_COV644_6.0_h_25.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null C8orf48 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38236 colorectal adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.586828 APCDD1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0072697 BRD-K83494171 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35168 posteroventral (inferior) parietal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22388 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3365-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PGM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84443 SNU182 CCLE Cell Line Gene CNV Profiles 1.0 2.66535 BRD-K63270352 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.09156 FBXO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20345 GSE148692,GSE148695_2_v_3_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K17140735_-666_EFO27_6.0_h_11.1_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MAFG::NFE2L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.3451 BRD-K15025317_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RCOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73592 CNIH4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40134 BRD-K54285478 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02503 FOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.6701 Adrenocortical carcinoma_ACC_TCGA-OR-A5LH-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUDT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58209 TSPOAP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00586583 NEO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07556 DSH1 GDSC Cell Line Gene Expression Profiles -1.0 -1.79421 JHU011 DepMap CRISPR Gene Dependency 1.0 3.59653 BRD-K06166879 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61068 FOXH1-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SLC25A19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20874 SJSA1 CCLE Cell Line Gene CNV Profiles 1.0 1.48241 ITGA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12587 Colorectal adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.333 BRD-K63250790 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44124 GSE199606_3_v_0_ricin_mouse RummaGEO Drug Perturbation Signatures -1.0 null ITGB2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00801712 KARPAS422 CCLE Cell Line Gene Expression Profiles 1.0 2.25277 SDC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00464296 Gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.890516 MIA PACA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03632 STAT3 JASPAR Predicted Transcription Factor Targets 1.0 null Large intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.892092 BRD-K86574132_-666_SKMEL28_6.0_h_48.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GDI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50421 SCC4 CCLE Cell Line Gene CNV Profiles 1.0 2.09557 BRD-K98195492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30049 BRD-K65320638 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14399 HK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00477583 NECAB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28741 SUMO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89857 ZDHHC7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68156 anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.962817 anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.858419 FOXA2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNRNPM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44762 BRD-K62459624_T5212475_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null LDLR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00459791 BRD-A34774643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06007 RAB11FIP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32628 KDM2B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00657578 Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.8895 abnormal lymph node morphology MGI Mouse Phenotype Associations 2023 1.0 null BRD-K21968411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1696 ELP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58008 ZC3H12C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.782 hsa-miR-4762-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 CHST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62905 COR-L95 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-4328 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 posteroventral (inferior) parietal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20282 SEC22C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14506 hypothalamus BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.58171 hsa-miR-4499 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19512 SKMEL28 CCLE Cell Line Gene CNV Profiles -1.0 -1.73225 CBX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33491 CPSF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39563 BRD-K18909381_-666_SKB_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null KMT5B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0115922 C8orf58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77473 TMEM44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83848 GSE200320_3_v_2_mfge8_mouse RummaGEO Gene Perturbation Signatures 1.0 null IST-SL1 GDSC Cell Line Gene Expression Profiles 1.0 1.56484 intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GOTO GDSC Cell Line Gene Expression Profiles -1.0 -2.26343 ZNF76 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79037 Caco-2/BBe cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.785 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.6559 BRD-K92571446_WZ-3105_PC3_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-A41250203_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IFI44L LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00639604 PRR36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80395 FSTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69918 OVCAR3 BioGPS Cell Line Gene Expression Profiles -1.0 -0.999545 Intestinal mucosa TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PPARD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.5525 CRCGN016_MCF10A.WT.HP_24H:O09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.19495 SEPTIN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9302 OVOL2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00604035 calcium channel activity GO Molecular Function Annotations 2015 1.0 null primary motor cortex (area M1, area 4)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.02995 BRD-K49313348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09917 CD56+_NKCells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.05703 BRD-K40373196_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ASIC2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00721517 BRD-K24132293_PIPLARTINE_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K99749624_S1003_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K26214026 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48512 SP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07507 BRD-K86472598_-666_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Colonic epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.89 CRCGN010_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4385 RPIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01841 RDES CCLE Cell Line Gene CNV Profiles 1.0 1.46076 PANX2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00544574 Adenoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.335 CREBZF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65516 SNU216 CCLE Cell Line Gene CNV Profiles 1.0 1.41943 mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.69388 BRD-K30055322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64658 BRD-K00877314 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6228 ventrolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.924252 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05807 TTT complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.811 Appendix disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.353 MEF2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.7543 dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.84333 BRD-K15409150_penfluridol_NCIH1694_6.0_h_30.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K70695911 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16806 BRD-K06049932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10862 ENPP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26821 IMPACT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91616 TNFRSF13C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39368 DIDO1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00848222 STRADB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0060745 KLHL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48963 PTOV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82067 BRD-K54420800 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38439 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.00128 dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19779 CDX2-22108803-LS180-HUMAN ChEA Transcription Factor Targets 2022 1.0 null RPAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97547 GSE160373_6_v_4_pparg_mouse RummaGEO Gene Perturbation Signatures -1.0 null cation transmembrane transporter activity GO Molecular Function Annotations 2015 1.0 null BRD-K16485616_S1122_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PHOX2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.7549 Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RLN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55566 NCI-H82 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.855496 RSPO1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00630081 PFKL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27299 TRPC4AP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2479 NCVADR RES BioGPS Cell Line Gene Expression Profiles -1.0 -1.15633 KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.874494 FOXC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 123.343 PIGS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71601 lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.53062 Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K72414522_AZD-5438_HME1_24_h_3.33_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN010_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.75941 BRD-K82135108_elesclomol_SW948_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE144838_1_v_8_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null MTMR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.62397 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.367 ALKBH8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10453 IMR-5 GDSC Cell Line Gene Expression Profiles -1.0 -1.41829 AKNA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14372 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16208 SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.854729 MCRS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99814 NR3C1_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOXA5 JASPAR Predicted Transcription Factor Targets 1.0 null CRCGN015_HEPG2_48H:G02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04785 FLT3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.006506 GATAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97155 BRD-K71935468_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K88378636_withaferin-a_HA1E_24_h_10_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K97399794_Quercetin_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K51215422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56448 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.55326 CD71+_EarlyErythroid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.08669 CA3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00684622 BRD-K96077293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21367 Hmga1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.877 RNF175 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26004 FBH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97218 GAL3ST2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00573901 CRCGN008_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.30185 H3K9me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null DAN-G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.26052 BRD-K52106083 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22627 MMP19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43359 SMAD3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00534054 BRD-K29834680 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07469 lovo cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.25324 POPDC3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00864658 SNRNP200 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24322 BRD-K54785440 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73995 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05808 BCL6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.8058 Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08999 HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.855496 RAB5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48927 BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_TYKNU_6.0_h_80.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PCK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0104619 IL17RC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.60218 Lymphocyte count GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.5699 VMCUB1 CCLE Cell Line Gene CNV Profiles 1.0 1.95023 CYRIA LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00652174 ATP8B4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00624776 ZBED2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31116 PLXNA4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00770396 ZNF354A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 144.186 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A61V-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-A36318220_Necrostatin-1_RKO_6.0_h_160.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SI LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.0072091 Basolateral plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.83 DPEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54616 NR3C1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.256 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058072 SLC13A1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00497507 cation transport GO Biological Process Annotations 2015 1.0 null BRD-K42966513 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29065 TLCD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16784 SNB19 BioGPS Cell Line Gene Expression Profiles -1.0 -1.18418 NCIH650 CCLE Cell Line Gene CNV Profiles 1.0 1.47818 GSE165647_2_v_1_cry2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PLEKHG6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06449 CENPQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50638 NCI-H1105 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K70875838 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34288 hippocampus (hippocampal formation)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18071 CNTN3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00525698 R3HDM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46643 STK31 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0066324 RNASET2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35287 CRB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12061 SKN3 DepMap CRISPR Gene Dependency 1.0 2.55612 HOXA10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.9961 ZNF367 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00624817 Telencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BRD-K58149231 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.42163 Brain ventricle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GBP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00452173 U138MG CCLE Cell Line Gene Expression Profiles -1.0 -1.91645 SNF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08996 BRD-K49371609_528116.cdx_HA1E_24.0_h_0.09_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.227445 orbital frontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.999801 RARB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25133 NCI-H292 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46137 Colorectal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.303 CXCL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68224 BRD-K74514084_S1035_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PFKL LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00821493 NFILZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33012 BRD-A63583287_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H2029 COSMIC Cell Line Gene Mutation Profiles 1.0 null Small intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ERICH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13721 SLC25A12 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00564407 BRD-K94777797 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27262 CRCGN015_HEPG2_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.95145 BRD-K32636001_MLS-0437446.0001_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-6144-11A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAS2R5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42325 substrate-specific transporter activity GO Molecular Function Annotations 2015 1.0 null BRD-K37561857_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null KDM1A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00449599 BRD-K13697445 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08635 CRCGN015_MCF10A_48H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.39717 GNB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11103 TPCN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99667 BRD-A96536816 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52964 496100369_PCx_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 10.2752 VCX3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50396 ALAD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41751 stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29326 TM31 CCLE Cell Line Gene CNV Profiles 1.0 1.42897 Colon Carcinoma DisGeNET Gene-Disease Associations 1.0 null MAST2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.174 SSTR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42923 Nkx3-2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.4833 CAMA1 CCLE Cell Line Gene CNV Profiles -1.0 -1.91325 FCHSD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23948 PTGER3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0059169 MPV17L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68611 FOXA2 ENCODE Transcription Factor Targets 1.0 null hsa-miR-3972 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 hydroxyprogesterone LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26995 UNK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3797 ACTL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49671 BRD-A06352508_SB 218078_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE112174_5_v_7_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PRECLH CCLE Cell Line Gene Expression Profiles -1.0 -1.47594 CRCGN010_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.63806 H2BC11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00779008 MAFK_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHAX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26234 BRD-K81515704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.12285 striatum_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12483 TCF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98237 GP2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00504395 SHD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22173 BRD-K34092021_Arvanil_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ACAA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.15079 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.647 primary auditory cortex (core)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10858 SuperiorCervicalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.42069 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.903174 BRD-K38904629 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30098 BRD-K13109628 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19322 NCIH2228 CCLE Cell Line Gene Expression Profiles -1.0 -2.51946 ADORA2A LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00471462 ZNF480 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05141 BRD-K81721884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2985 hippocampus (hippocampal formation)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26401 FOXO4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.2624 CRCGN015_MCF10A.TP53.M_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.1608 APAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.57162 MDA MB435 BioGPS Cell Line Gene Expression Profiles 1.0 1.05913 VPS37B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00487619 GMFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33041 Adrenocortical carcinoma_ACC_TCGA-OR-A5J9-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RMUGS CCLE Cell Line Gene Expression Profiles 1.0 1.82571 17210682-Table2a GeneSigDB Published Gene Signatures 1.0 null IGFBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82788 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.456 Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z4-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null N4BP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34813 Perturb_16550_KO_Pclaf_SRP130991 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.97478 Stomach cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 CD320 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99887 BRD-K74148702_curcumin_HA1E_24.0_h_48.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K78816149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01409 BRD-K21680192_mitoxantrone_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FOXP3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.9748 intestinal mucosa TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K11804865 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45 dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.71274 FOXA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.7025 primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10761 ASAP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00953348 CALM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15505 KCNG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58748 TTC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43999 BRD-K13646352_-666_NPC_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K58607444 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8743 H2AC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99894 Colonic mucosa TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SLC7A10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74411 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MH-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TSR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8845 NRM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86407 AAK1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00528708 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MMACHC LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00650931 BRD-K43389698_BMS-387032_HME1_24_h_0.12_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K56653679_-666_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HOXC13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5065 CRCGN015_MCF10A.TP53.M_24H:O23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2933 BE-13 GDSC Cell Line Gene Expression Profiles 1.0 1.84925 ELOF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00612261 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07859 CRCGN016_MCF10A.TP53.M_24H:G10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.37439 ML1 CCLE Cell Line Gene CNV Profiles -1.0 -1.46071 FASTKD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00593237 Colonic mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.193 NR2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.2941 icSARS CoV_30Hour_None_GSE37827 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.33458 single-organism localization GO Biological Process Annotations 2015 1.0 null TP53I13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56761 MAST2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0045132 DTWD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72602 KRI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15389 BRD-K82791632 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61883 PRDM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86061 JHH-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null PABPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21547 hsa-miR-548i TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 BRD-K94346447 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02322 ERGIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75805 IFIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19626 binding GO Molecular Function Annotations 2015 1.0 null PBXIP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00725082 CRCGN014_HEPG2_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.29807 NR1H4::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6111 TCEA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2598 ONECUT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.6648 EPPK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7226 primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0091 BRD-K30296925_FLAVOKAWAIN B_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN017_MCF10A.WT.HP_24H:P09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.57175 CRCGN010_HEPG2_24H:H07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.6181 SLC29A4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00694935 PLAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91263 ANXA3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00352423 AMMECR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60612 WM1799 CCLE Cell Line Gene CNV Profiles 1.0 2.06302 LCP1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00710183 HMX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33177 PRR14L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83665 GNMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39809 HUCCT1 COSMIC Cell Line Gene Mutation Profiles 1.0 null nucleus of diagonal band Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04306 colonic epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.21223 FSHR LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00627114 Intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 OE21 CCLE Cell Line Gene CNV Profiles -1.0 -1.40563 Acute Myeloid Leukemia_LAML_TCGA-AB-2855-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 8505C CCLE Cell Line Gene Expression Profiles 1.0 1.54725 KLC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16502 SP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27033 TAL1::TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.0682 BRD-K60870698_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Anchored component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.632 NR0B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.32387 IGSF9B LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00511841 BRD-K44260904 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.47999 THOP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12682 BRD-K24387065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02644 CRCGN017_MCF10A.TP53.M_24H:P21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17801 EZH2_DEPLETION_GDS2445_117_human_embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null FOXD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 77.6225 XRCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12926 FGFRL1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00670209 KG1 CCLE Cell Line Gene CNV Profiles 1.0 1.51682 Brain Lower Grade Glioma_LGG_TCGA-HW-8319-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.19625 salivarygland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 TE4 CCLE Cell Line Gene CNV Profiles 1.0 1.35457 PARG LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00870141 Temporal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BRD-A27887842_PREDNISOLONE_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null THOC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73556 BRD-K54003455 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19529 H3118 DepMap CRISPR Gene Dependency 1.0 3.06342 BRD-K67936348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07491 CACNA1H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13457 RH30 DepMap CRISPR Gene Dependency 1.0 2.94738 SP in caudal cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05284 ANG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04961 IST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02184 UAP1L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58096 BRD-K23412959_NCGC00165188-01_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K31024887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80392 HARBI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55987 NCIH1573 CCLE Cell Line Gene Expression Profiles -1.0 -2.12615 SOX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.1229 ZNF513 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77853 SKMEL24 DepMap CRISPR Gene Dependency 1.0 2.4029 HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null CRCGN017_MCF10A.TP53.M_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.15921 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A1-11A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.15759 BRD-A76490030_K784-3131_PC3_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null VGLL3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00463993 PRR35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4966 SETDB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28233 OCILY10 CCLE Cell Line Gene Expression Profiles 1.0 2.13326 FOXS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.4519 MHH-NB-11 GDSC Cell Line Gene Expression Profiles -1.0 -1.5943 hutu80 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.598 CRCGN011_HEPG2_24H:H21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6615 SIPA1L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73039 AIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06675 CRCGN012_HEPG2_24H:D01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.24372 TTBK2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00802002 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.21428 BRD-A18497530_EI-293_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null kidney TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TMEM163 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00811386 BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K98519785 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23347 Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.918075 BRD-K22093396 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.35578 T47D Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.37913 BRD-K16485616_S1122_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null C18orf25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91657 FOXA3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.9609 UBALD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87046 PMC9577795__F4 PFOCR Pathway Figure Associations 2024 1.0 null PPFIA1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00512068 dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1591 UBE2L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41699 TOE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45118 Rectum adenocarcinoma_READ_TCGA-AH-6643-11A-01R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAPKAPK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26128 SCRN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88138 SIKE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73937 NKX2-1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27229 BRD-K48325920 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77922 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065929 Stomach TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 METTL2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.50846 BRD-K15341710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03116 KCNK7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00472302 BRD-K29379705 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13534 Gata3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.7975 BRD-K36170758 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17985 PANK4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00510362 CRCGN009_HEPG2_24H:C08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27731 FDXR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78136 CRCGN016_MCF10A.TP53.M_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03402 MKN28 DepMap CRISPR Gene Dependency 1.0 3.94623 POU2F1::SOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.108 OLIG1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00845175 SNAI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.421 Mesothelioma_MESO_TCGA-SC-A6LN-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.TP53.M_24H:F14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.82287 HMGB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.943 H2AFZ ENCODE Transcription Factor Targets 1.0 null ATP1B3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00566797 BRD-K94493764_NP-009169_HA1E_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PDPR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77849 Polysomal ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.87 OFD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30376 Hnf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.6741 Nfat5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.8596 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A729-06A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-A3M2-01A-21R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4477a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 MST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3763 CSF2RB LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00509791 ZNF391 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00819267 CRCGN013_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5774 LYRM9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79959 LGI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39423 BRD-K70327191_BENZOXIQUINE_HCC515_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K57184137 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16954 HCC1395 CCLE Cell Line Gene CNV Profiles 1.0 1.6903 CRCGN016_MCF10A.TP53.M_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.1652 FOXF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.5673 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.14602 UMUC9 DepMap CRISPR Gene Dependency 1.0 3.34115 MRPL20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8427 PAQR9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50302 FAM222B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43542 KCNA4 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00496375 PSG7 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00973245 SCRT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3001 Rectum adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.568 CHMP4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19359 MedullaOblongata BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.03911 MRPL21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09951 TEF LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00816647 BRD-K41207293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32986 SLC4A11 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00661216 Rectum cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.621 BRD-K49371609_528116.cdx_SKMEL28_6.0_h_0.09_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K20203758 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31061 CKM complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.762 NFATC3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4019 SLC35C2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00706 MAPK1IP1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81758 PRM3 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00504407 TAF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80961 Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.353 MGAT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.65239 whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 KARPAS-422 GDSC Cell Line Gene Expression Profiles 1.0 1.92901 PFKM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78668 TRAF1 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00837936 CRCGN016_MCF10A.WT.HP_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.22027 RAVER1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.07952 CRCGN015_HEPG2_48H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.29653 RAB6C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3199 striatum_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06969 primary somatosensory cortex (area S1, areas 3,1,2)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.872315 CEBPB JASPAR Predicted Transcription Factor Targets 1.0 null ZNF680 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.3968 BRD-K70549064_EI-156_PC3_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81G-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACE LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00594228 LoVo cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.376 Colon descendens TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.71 Outer mucus layer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.524 CD9 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00597976 H3K9me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lyf-1 MotifMap Predicted Transcription Factor Targets 1.0 null CRCGN016_MCF10A.TP53.M_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.74674 BRD-K11516621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09105 SART3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14623 JAM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02177 PPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44948 BRD-K17176016 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16103 SCH DepMap CRISPR Gene Dependency 1.0 2.16538 MAPK11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16568 RTN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48882 ASB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63199 outer plexiform zone in extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07215 BRD-A20697603_598226_A549_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BEND6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.39567 EFE184 CCLE Cell Line Gene Expression Profiles 1.0 1.40958 BRD-K61217870_-666_HCC515_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HORMAD2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00610287 single-organism cellular process GO Biological Process Annotations 2015 1.0 null BRD-K49042040 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.74551 NSMF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15958 orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.98287 SLC30A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94244 INMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27823 UBE2Q2 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.00682923 CRCGN016_MCF10A.TP53.M_24H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48355 PMC6529539-41598_2019_43492_MOESM5_ESM.xls-Table_S4b-Table_S4b_Normalised_log2_data_of_RETRO-C_FFPE_samples_profiled_using_the_modified_protocol_Normalised_to_HKs_RPL13a_PPIA_ZNF384_ZNF384 Rummagene Transcription Factor Associations 2026 1.0 null MAP7D3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00905 Adrenocortical carcinoma_ACC_TCGA-PA-A5YG-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EOLA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04831 HSF1_01_155 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.43133 BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HA1E_24.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PTK7_knockdown_185_GSE50138 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.74778 BRD-A16332958_-666_MCF7_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN009_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.66508 CRCGN015_HEPG2_48H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.06361 CRCGN016_MCF10A.WT.HP_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9198 BRD-K57014223 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04841 RABEPK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92837 PUM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73456 NR2F2 ENCODE Transcription Factor Targets 1.0 null MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null plasma membrane LOCATE Predicted Protein Localization Annotations 1.0 null Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.545 ZNF397 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52813