association	dataset	threshold value	standardized value
KCND1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554917
SRMS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00678454
BRD-K49630153_NCGC00183226-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CHRNB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00668632
GSE131649_4_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3817
STARD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61864
LYZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00389674
BRD-M34385771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26615
BRD-K35708212_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Postsubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52625
respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.061514
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2112
CCDC181	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00757113
4101_ILKAP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535493
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
TEK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522118
BRD-A04618830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50008
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054271
BRD-K84423439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04994
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3182
APP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63123
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.3993
hsa-miR-485-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K21937603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18642
BRD-K47292239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05758
BRD-K30217326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.97433
BRD-K84935903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14027
SIRPD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00783945
endomembrane system	GO Cellular Component Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-7454-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K22065327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07557
105_ACTG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.594849
6214_PELO_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517816
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0391
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6842_PSMA2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.836933
BRD-A89434049_SARMENTOGENIN_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FAM20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84517
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44377
BRD-K14909006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05761
Blood_CT2_eosinophil	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
2292_DNAJC19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.704535
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.0516
5583_NEDD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.718453
ALAS2_OE_GDS2118_74_human_Blood	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
trim28_23493425_cd71pluster119plus_sorted_from_bone_marrow_lof_mouse_gpl6887_gse44063	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.210296
ZPBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585086
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.887211
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03647
CMK86	CCLE Cell Line Gene Expression Profiles	1.0	1.35459
BRD-A35588707_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OSBPL6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646891
ZKSCAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20907
J7 hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
6040_PAICS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.569728
PMC5322933-pone.0172430.s013.xls-Pathways_MSC_Single_Basal_vs_MS-Unnamed_1_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.522889
GIMAP8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00662031
BRD-K50718861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38643
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.503141
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.5
SUMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00475312
6236_PFAS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500864
HL-60	GDSC Cell Line Gene Expression Profiles	1.0	2.04189
TNFRSF19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0059204
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34028745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19656
RBM39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82096
CDKN1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0074969
Ventral anterior-lateral complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46245
DKK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00546535
BRD-K65366129_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K84348716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5459
Intracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
HLA-DMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0046314
BRD-K97309399_THIOTHIXENE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.278
secretory granule membrane	GO Cellular Component Annotations 2023	1.0	null
Anteromedial visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01238
BRD-K89732114_trifluoperazine_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A8YI-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047317
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K37634338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50352
IL3RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055878
NOTCH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0047802
intermediate stratum of r3Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14851
Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NM-01A-21R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NTRK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00631015
BRD-K69840642_HDAC6 inhibitor ISOX_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NDUFB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00879096
ESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0462
r4 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.81863
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06834
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CP-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventral lateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74964
VSTM2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00928663
BRD-K35708212_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K50345393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75141
1667_CLNS1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.686599
LIMK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00464355
bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
NFATC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10041
BRD-K14920963_ERYTHROSINE SODIUM_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
5599_NELFB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516145
10163_ZNF131_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.672089
NCIH2052	CCLE Cell Line Gene CNV Profiles	1.0	1.45031
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X2-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCIRG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0073208
ovary cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.276145
gdm1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.914
Myeloid neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
BRD-K87808996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07915
pleural fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.268828
NPY5R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00718143
10174_ZNF146_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.546453
CYP2C9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639503
NQO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619224
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.96713
BRD-K56558538_Ambroxol hydrochloride_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K55895855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39873
Perturb_10203_KO_SLC35F2_ERP006028	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.0744
1840_CPSF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.90612
Alzheimer's disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6110_PCBP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.00844
GLYCTK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00667059
6511_POGZ_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.675997
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-2_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92571446_WZ-3105_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052843
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053351
BRD-K91623615_ABT-751_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A55594068_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K70891562_STOCK3S-04022_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8770_ELOB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.728244
TAS1R2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00733601
BRD-K69791255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02575
AKAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11739
8904_TICRR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.542823
MS4A7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00673245
BRD-K89093471_VU0418934-2_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K36862742_hydroflumethiazide_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
tauopathy	GWASdb SNP-Disease Associations	1.0	0.757675
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.78553
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	114.012
Fc-epsilon receptor I complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.123
LOXIMVI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A52729710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52959
CRCGN016_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.142
ALVA31	BioGPS Cell Line Gene Expression Profiles	1.0	1.00621
Primary somatosensory area, upper limb, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50133
MONOMAC1	CCLE Cell Line Gene Expression Profiles	1.0	1.79895
Taenia tecta, dorsal part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42749
NECTIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06477
BRD-A19500257_geldanamycin_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
4281_KAT8_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.545903
SETDB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00443429
BRD-A80960055_3203_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PTPN22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00532772
hsa-miR-3165	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
2538_EIF2B4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.723542
BRD-A75144621_digoxin_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POGLUT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00503592
SOX12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4159
HIPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00712225
Orbital area, lateral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11132
BRD-K79347397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57808
BRD-K56408846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67906
Perturb_14789_OE_GPRC5C_ERP125648	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.38857
LEO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.43212
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.191
Golgi cisterna membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.804
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
PFDN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00826535
CARD6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00724819
BRD-K78074905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19406
BRD-K64797043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42759
RIMS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00624362
ATR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0115191
2521_EHMT2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.783747
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MU-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78615842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13376
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.703
MEG-01	GDSC Cell Line Gene Expression Profiles	1.0	1.8021
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	86.3538
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.498
BRD-K71262871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.74332
BRD-K66032149_VU0365117-1_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KU-812 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.961
PMC5932012-41467_2018_4180_MOESM18_ESM.xlsx-Table_19-GSEA_Gene_lists-Zuber_Myb_KD_DN_HUMAN_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.074791
IL18R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00801015
5356_MVD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.883784
BRD-K99616396_S1032_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K37991163_PAROXETINE HYDROCHLORIDE_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KLE	DepMap CRISPR Gene Dependency	1.0	3.94226
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044119
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.6191
layer 5 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03689
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.721
BRD-A19500257_geldanamycin_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HEL	DepMap CRISPR Gene Dependency	1.0	2.28819
LTBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38235
SG in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.911507
HYCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49202
BRD-K89732114_trifluoperazine_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF512	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604767
IGR-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059053
BRD-K94441233_Mevastatin_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EGR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00377084
8098_SLC4A7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.56571
BRD-K79090631_CGP-60474_SKBR3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDGFL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00421847
PMC6962646-mmc2.xlsx-StemCell_Genesets_2018-LIN28A_LIN28A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39624
layer 6 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38231
GIMAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644071
BRD-K05137000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28386
IFI30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17322
MV3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.681
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81418486_vorinostat_PL21_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8787225-Data_Sheet_1.xlsx-STable_2_DEG-Supplementary_Table_2_1150_up-_and_down-regulated_differential_expressed_genes_upon_GATA2_activation_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
Azurophil granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.541
BRD-K92428232_GSK-461364_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZBTB18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07276
ZNF573	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02291
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PAK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0124612
BMI-1_DEPLETION_GDS2445_115_human_embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
496100443_HIP_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44345
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MS-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
HEY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00488556
BRD-A60513937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71569
BRD-K66870022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10653
ATP5F1D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00702915
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6324-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32000549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3099
Granulocyte-monocyte progenitor_Umbilical cord blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
VZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44461
HSD17B6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00735742
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7528
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.11119
SLC26A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00440005
BRD-K04325154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50731
1939_CTNNBL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.709369
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.138
BRD-A19500257_geldanamycin_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92571446_WZ-3105_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
9479_UBA2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.67797
BRD-K53901855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33179
ANKRD44	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00895828
SKRC20	DepMap CRISPR Gene Dependency	1.0	2.7136
FASTKD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00484205
SOX10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00919142
TAB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.009574
BRD-A62182663_YK 4-279_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CD55	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00455717
Kidney Chromophobe_KICH_TCGA-KN-8428-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HEL	GDSC Cell Line Gene Expression Profiles	1.0	2.39389
6846_PSMA6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.784393
CD74	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00712375
Prostate adenocarcinoma_PRAD_TCGA-EJ-5531-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OXSR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00728009
LCP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602331
cell property	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.126451
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.558457
BRD-K07259155_NCGC00182362-01_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FCRLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00837737
1312_CCDC9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.568891
Blood_CT2_eosinophil	HuBMAP ASCT+B Annotations	1.0	null
1873_CRIPT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.545323
BRD-K69852452_7241-4207_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC6A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00612646
BRD-K46119789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77829
CLN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00687265
METAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0047095
BRD-K34632780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04796
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A89575866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41445
IP6K3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00657774
TUFM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636479
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.87993
BRD-U82589721_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RUNX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8308
PANC0813	DepMap CRISPR Gene Dependency	1.0	2.4078
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0522
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8034
hsa-miR-4319	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K24133999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18769
r2 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31932
BRD-A51777634_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ABCA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00696785
PADI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0105011
BRD-K86268010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40475
2556_EIF3L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50698
r5 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.13789
BRD-K37991163_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K37015376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63894
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042009
Perturb_9244_KD_ENL_SRP074134	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.5719
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.54217
BRD-K76810206_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
CRCGN009_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00715
1545_CHAF1B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.44453
r2 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57425
BRD-K15592317_CP466722_BT20_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CANX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00793052
PKDCC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00807298
BRD-K03557653_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
2935_DIPK1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.623065
NDOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70715
BRD-U07805514_saracatinib_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SPHK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568331
BRD-K44100512_KIN001-043_MDAMB231_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GP1BA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00514733
PDCD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00638269
BRD-A68526335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10873
Blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.787
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.834914
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.8787
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6724
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11708
3994_HUWE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.569986
BRD-K49865102_PD-0325901_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LINGO3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00674351
BRD-K33379087_tivantinib_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SPI1	ChEA Transcription Factor Targets	1.0	null
BRD-K56196992_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MPPE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59246
BRD-A19500257_geldanamycin_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K03902845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95013
UBQLN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00498903
Ileal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.617
BRD-K23282736_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC3526356-supp_jem.20121387_JEM_20121387_sm.pdf-27-MEIS1_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
9506_UBE2I_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.37943
Respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K19216856_(-)-Gallocatechin gallate_WSUDLCL2_6.0_h_88.8_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LAMA-84	GDSC Cell Line Gene Expression Profiles	1.0	2.90674
CMTM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0103922
Cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1925
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_4day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.34311
ADCK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00691396
COX5B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00518336
GAD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563626
ZCCHC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15294
BRD-K71221636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65827
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.875633
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08003
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-8_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.94955
r1 part of intermediate nucleus of the lateral lemniscus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08043
BRD-K18855837_PZ0004_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K10995081_PERPHENAZINE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RAB8B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632673
TAF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066921
BRD-K65182930_NVP-AUY922_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A23723433_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8154_SMARCE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.569884
CRCGN009_HEPG2_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01397
CAMKK2 pathway	WikiPathways Pathways 2024	1.0	null
NHP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00985281
BRD-A16998493_etodolac_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Sensory dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.54
CHRNA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00973385
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6821
BRD-K42918627_GSK-2126458_LNCAP_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6266
9267_TRIM24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.632296
BRD-K85985071_E3380_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K33986892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84376
MDK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86016
Taenia tecta, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.94949
GYPE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00580023
MZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.880386
8438_SRSF7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.01614
BRD-K06666320_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FFAR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.008373
Secondary motor area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32385
WDR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00780319
BRD-K06020071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27779
TE4	CCLE Cell Line Gene CNV Profiles	1.0	1.35897
5598_NELFA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.09902
RECQL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614006
NRARP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5292
4631_LPCAT2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560247
BRD-K89784888_2339-2182_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8615
Lung squamous cell carcinoma_LUSC_TCGA-22-1016-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K99380810_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ADORA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677915
6515_POLD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504696
BRD-K67042874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64995
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.032166
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.1667
BRD-K90735586_5-PHENYL-4,7-DIHYDROTETRAAZOLO[1,5-A]PYRIMIDINE (Compound C)_CL34_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ventral juxtacommissural pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45935
Primary somatosensory area, unassigned, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56373
integral component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.146414
BRD-K68065987_MK-2206_LNCAP_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K49328571_dasatinib_MDAMB231_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
thymic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.654212
9312_TRMT5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521471
Vitamin B12 Measurement	DisGeNET Gene-Phenotype Associations	1.0	null
GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD81	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516607
lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.214975
BRD-A18419789_Etoposide_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cterminal	GeneRIF Biological Term Annotations	1.0	null
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08431
FCRL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00577902
PDLIM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00999873
BRD-K37601439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5042
DUSP6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061679
BRD-K39773004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75652
VPS18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00617116
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.225
MAP3K12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586061
PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K37724988_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A93236127_DIGITOXIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
proteasome accessory complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.304027
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.086432
BRD-K58277621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13758
496100640_PCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0741
7753_SEC61G_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.67381
MC1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19267
CLK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00659954
SCN3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00825609
Perturb_9024_KD_NR4A2_SRP324495	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.23399
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0047
496100336_TCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31896
Brain Lower Grade Glioma_LGG_TCGA-DB-5279-01A-03R-2347-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060218
CRCGN014_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06023
4553_LEO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.46979
8432_SRSF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.660539
BRD-K13390322_AT-7519_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
small intestine epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.790212
BRD-K87131514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2019
hsa-miR-4306	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
SLC18A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00557852
tcof1_15522210_neuroblastoma_lof_mouse_gpl339_gds998	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.141678
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HG-A2PA-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6050_PAM16_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.680908
BRD-K15933101_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K82433264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64696
Lung adenocarcinoma_LUAD_TCGA-44-3918-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
embryonic fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.097903
RELA_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
r3 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.07018
mantle zone of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73396
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.620509
hsa-miR-3647-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
K562	CCLE Cell Line Gene Expression Profiles	1.0	1.38263
ZNF280B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00701294
VGLL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561551
Immune System	Reactome Pathways 2024	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062295
BRD-K03122949_5102-0187_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
4960_MEF2A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.970025
9474_U2AF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.531704
BRD-K68202742_trichostatin A_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K90519599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03484
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2297
r11 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04664
OR5F1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00811909
TPBGL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00755662
BRD-K59437706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33029
BRD-K76907295_VU0418947-2_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
White Blood Cell Count Procedure	DisGeNET Gene-Phenotype Associations	1.0	null
MYB_01_48	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.58011
hsa-miR-2117	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
deep layers of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.9139
RPL17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00786513
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.5248
4985_METAP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.900794
Specific granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K61127831_VU0413247-1_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K65932559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35669
6889_PSPH_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.67497
NFKBIA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00576164
7893_SEM1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.601268
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K04623885_BIBR1532_NCIH508_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K23593468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89324
wi-38 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.47348
RNASE3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00704963
BRD-K92431275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88914
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TSSK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00714905
SELENOH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33247
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.138
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046022
6862_PSMC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.736325
BRD-A11512624_NCGC00181381-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bone_Marrow-granulocyte	Tabula Sapiens Gene-Cell Associations	1.0	2.32596
BRD-K37150847_methyl (3-phenyl-1H-indazol-1-yl)acetate BRD-K37150847_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K76703230_YM-155_H1299_6.0_h_0.310000002384_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A52024592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98668
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Intestinal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.647
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-4593-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.6383
ITPRIPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00865661
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_NCIH508_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
bronchial mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.574017
sublayer 6a of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41431
STAT5A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.621128
BRD-K74148702_curcumin_MCF7_24.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87084
BRD-K42805893_HG-14-8-02_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STK26	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00634121
BRD-K64606589_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6792_PRPF19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.515041
BRD-K94325918_-666_RMGI_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JAK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61152
BRD-K21680192_mitoxantrone_BT20_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STK35	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00859389
BRD-K40175214_torin-1_LNCAP_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18103
nuclear part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041451
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562	BioGPS Cell Line Gene Expression Profiles	1.0	1.76622
BRD-K68548958_-666_HA1E_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of PCx (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83535
PRPF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29125
BRD-K45076286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83992
hematopoietic cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
9272_TRIM33_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.76679
SCML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50818
SLC6A13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00578685
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44377
BRD-K60274257_Dephostatin_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K20526256_HG-14-10-04_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K26233698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07296
AKT2_knockdown_44_GSE12291	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.73802
myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.222938
SCG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09765
SYNPO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0089006
BRD-A01717111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12698
bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.243295
hsa-miR-4756-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09557
BRD-K78599730_manumycin A_SNGM_6.0_h_9.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
vitamin b 12	GAD Gene-Disease Associations	1.0	null
EIF2AK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00786171
BRD-A77216878_manumycin A_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K44897610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42944
7155_RBM14-RBM4_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.809508
CMK	CCLE Cell Line Gene Expression Profiles	1.0	2.3566
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
16857994-TableS1	GeneSigDB Published Gene Signatures	1.0	null
ACTN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00611122
SARS-CoV NSP16_Day7_None_GSE49263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.56787
GOT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613865
BRD-A93236127_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
2542_EIF2S2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.655192
KIAA0040	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78191
BRD-K08307026_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TP53	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00806098
Specific granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.064
central layers of TG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02249
SP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35737
ZNF696	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.339
CENPV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24541
BRD-K23363278_CYT997_MCF7_24.0_h_1.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
USP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71062
BRD-K54997624_BYL719_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K72414522_AZD-5438_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Blood-neutrophil	Tabula Sapiens Gene-Cell Associations	1.0	6.2301
DIDO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77842
TFAP2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00565267
BRD-K28178212_G3420_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SKM1	CCLE Cell Line Gene Expression Profiles	1.0	1.64089
BRD-A68930007_OUABAIN_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
4153_INTS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.17807
SLC2A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00789927
BRD-A19500257_geldanamycin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0151955
GM2493	BioGPS Cell Line Gene Expression Profiles	1.0	0.845368
BRD-K80888628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66536
BRD-K76543697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.6106
5244_MRPS14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.612394
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.078
GSE196117_1_v_7_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
5713_NME4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540849
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.994439
BRD-K86472598_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.265849
6515_POLD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.82331
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9282
FAM135A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5834
EW22	DepMap CRISPR Gene Dependency	1.0	2.4668
PRKAB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539629
1118_C7ORF26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.632061
BRD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522521
BRD-K12119989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05943
AGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34029
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.200328
BRD-A80574334_13521_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K55127134_Fluphenazine dihydrochloride_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Baboon_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
layer 1 of LOT	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27393
CEM-ADR5000 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.824
PKN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581132
IL12RB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00722007
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K85402309_dovitinib_BT20_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TREM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00681778
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9369
BRD-K74710236_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
1781_COPS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.660187
RUNX1_01_47	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.88292
1351_CCT7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.907051
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.33388
BRD-K69852452_7241-4207_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4728-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K05649647_-666_AGS_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8603_SURF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.573837
BRD-K47366416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02508
IKZF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0074388
PIGV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614218
BRD-M86331534_BJM-ctd2-9_RMUGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_14170_KO_CDKN2A_SRP379417	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.70855
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7398-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PANC0813	CCLE Cell Line Gene CNV Profiles	1.0	1.53867
phenylketonuria	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.526904
posterolateral cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25324
BRD-K68185022_Ursolic Acid_HA1E_6.0_h_70.07_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZCCHC24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35978
ARFRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00448907
BRD-K90999434_-666_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
chr11_60048044_A_G_b38	GTEx eQTL 2025	1.0	1.4214
POLK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67247
2328_DOHH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.01927
BRD-A00881124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13071
BRD-K34595193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27431
APOH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531323
BRD-K20016759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27975
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.58809
BRD-K35026224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34037
BRD-A55913614_Primaquine diphosphate_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K86761848_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-NB4-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_NB4_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A19037878_trichostatin A_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
9172_TONSL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.590625
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.70991
LOX-1_OE_GDS4262_434_human_HAECT - aortic endothelial cell line - 12 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K00615600_Unable to generate chemical name O-4537-1_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A27887842_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DNMT3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00653389
KCNA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487893
MONOMAC6	CCLE Cell Line Gene Expression Profiles	1.0	1.53118
Vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
SPNS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00767404
BRD-K99198579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37381
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.8036
4682_LRSAM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.590567
4234_ITPK1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.86912
REL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00790239
THRB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00907453
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A19037878_trichostatin A_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RSBN1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00795205
layer 3 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66669
acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.063086
alzheimer's disease	GWASdb SNP-Disease Associations	1.0	0.757675
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.221025
1350_CCT6A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.503514
HTR7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00433339
NME8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00637099
GABRR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564827
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.869274
BRD-K68174511_torin-2_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3-5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89653
5579_NECAB3_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.645773
S100A12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0098645
AMHR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00560137
ZGPAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595213
gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.047665
PCTP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00934059
FLT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00612037
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
cotinine-5611	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KPNB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0154881
5476_NBAS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.639217
SNU216	CCLE Cell Line Gene CNV Profiles	1.0	1.42841
GCGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00727264
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12591
CD68	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00556253
specific granule membrane	GO Cellular Component Annotations 2025	1.0	null
GNAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00615322
RPL41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36019
BRD-K19894101_MST- 312_PC3_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A07029265_IPRATROPIUM BROMIDE_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intermediate part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00887
ENPEP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00732752
BRD-K43744935_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RGL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74888
BRD-K43389698_BMS-387032_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00913795
BRD-K91328526_Clomiphene citrate (Z,E)_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r3 part of cochlear sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9016
BRD-K42797038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37495
DPP8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00826763
Fbxl10_OE_GSE34691_579_mouse_fibroblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
DMPK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00843117
GAST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512687
BRD-K35687265_S1362_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-2690-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KP3	DepMap CRISPR Gene Dependency	1.0	2.271
ADCY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00756293
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.35892
BRD-K35046132_MLS-0437633.0003_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55886
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.81409
FGF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564773
ventricular zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.441042
MAP4K4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58107
DFFA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00475579
FDXR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78136
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5370-01A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EBC1	CCLE Cell Line Gene CNV Profiles	1.0	2.09208
CEACAM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00963111
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ARFGAP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660789
GSK3B_knockdown_206_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.39451
BRD-K68336408_Tyrphostin AG 1478_HA1E_24.0_h_56.78_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
1424_CDK12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.657958
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.55596
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2119
5493_NCBP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16534
PIGL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00947084
TRIM24_Deficiency_GDS3087_609_mouse_Hepatocellular carcinoma (HCC) tumors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
13_AARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.919445
Bone marrow_CT2_basophil	HuBMAP ASCT+B Annotations	1.0	null
9843_WDR77_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.675611
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47851
SRR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00852641
10648_ZNF804A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.507498
ADAM12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554966
WM1799	CCLE Cell Line Gene CNV Profiles	1.0	2.12666
BRD-K46124507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94111
BRD-K74402642_Chemistry 2804_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K10705233_GW405833 hydrochloride_SW948_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44433
OLIG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568914
BRD-K03549232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13119
BRD-U33728988_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4625-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00814051
endoplasmic reticulum	LOCATE Curated Protein Localization Annotations	1.0	null
Squamous Cell Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
BRD-K49666076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51635
SK-N-AS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
7634_SAE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.89105
BRD-A73605923_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMK1	DepMap CRISPR Gene Dependency	1.0	2.17041
AKAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3765
TEDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4344
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.266
8921_TIMM23B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.813517
M14	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PRKAR1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00507817
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YV-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR2F2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EVI2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00813173
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3925-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73523821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43959
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Yolk sac	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.718
SJSA1	CCLE Cell Line Gene CNV Profiles	1.0	1.49682
PRKG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0069367
3557_GSTCD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.926516
10689_ZNF888_ENST00000596623.1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506905
SLC38A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00556693
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Posterior parietal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01591
ARPC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00514537
BRD-K21680192_mitoxantrone_BT20_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XC-01A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U2AF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00894999
BRD-K54233340_Dorsomorphin dihydrochloride_HCT116_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.342285
COLO684	CCLE Cell Line Gene Expression Profiles	-1.0	-1.93752
4384_KIF20A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.599251
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056146
4424_KLF8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.628961
PMC9894241-pnas.2211429119.sd05.xlsx-G3_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
TOR2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82032
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.9792
BRD-K09661167_OSSK_645683_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6143-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE176008_7_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4909_MCPH1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.659497
TSLP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0078363
BRD-K41322154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33774
ZNF469	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9927
mantle zone of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57552
superficial stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1018
Prostate adenocarcinoma_PRAD_TCGA-EJ-7330-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00864789
Primary somatosensory area, trunk, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16574
4722_LYL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.635645
BRD-K77987382_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K53281329_SYK-inhibitor_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
5598_NELFA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.62616
BRD-K35708212_Strophantine octahydrate_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ADAM10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00538415
VHLL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00591879
periventricular stratum of the VAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03568
BRD-A35869383_ibrutinib_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mucoepidermoid carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hsa-miR-4509	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
PKMYT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00726837
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.829165
BRD-K15600710_S1057_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SKMEL30	DepMap CRISPR Gene Dependency	1.0	4.71621
HT55	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GRB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554897
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9869
H3K9me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
8923_TIMM44_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.733155
BRD-K93332168_Isocarboxazid_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZFHX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520643
BRD-K46056750_AZD-7762_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STMN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639408
BRD-K72034944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64289
10348_ZNF423_ENST00000262383.2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574469
BRD-A01320529_salmeterol_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DAPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635537
AAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604106
vitamin metabolic disorder	GWASdb SNP-Disease Associations	1.0	1.34295
9526_UBE3C_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.866247
PLOD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00248372
BRD-K49303291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11965
BRD-K47170544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35804
BRD-K49328571_dasatinib_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K57795803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48001
IDH3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0103098
UBAC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00546396
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.646072
SMC1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0149238
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OVCA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00721096
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.9074
Stat6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.4428
CXCR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00661752
8695_TARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.870473
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTPN12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00576848
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BRD-K02641134_2-(4-(tert-butyl)benzamido)-4-chlorobenzoic acid KUC105998N_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-A55408860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10303
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040537
GNAI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0097395
IL17RC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530122
CD20-like family	InterPro Predicted Protein Domain Annotations	1.0	null
1346_CCT2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.2646
CMLT1	DepMap CRISPR Gene Dependency	1.0	2.7631
BRD-K34858602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13199
Mitochondrial processing peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.255
BRD-K61168922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22975
FXYD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00763725
BRD-K21680192_mitoxantrone_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K48501991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55142
3517_GPS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516071
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.03025
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.40817
698_ATRX_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.05627
PMC9894241-pnas.2211429119.sd05.xlsx-G4_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13658
Progenitor cell_Blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072795
C9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00940453
4220_ITFG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.531722
pipenzolate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06722
thorax	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073722
6795_PRPF38B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.775852
BRD-A19037878_trichostatin A_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A25775766_Securinine_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K32405725_E933505_HEPG2_6.0_h_88.8_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K44100512_KIN001-043_A549_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PFKFB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00804222
KDM5B	ENCODE Transcription Factor Targets	1.0	null
jejunal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.946087
817_BEND6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504024
BRD-K11057086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06578
BRD-K57251296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1276
BRD-K07482874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27306
BRD-A11605036_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K06666320_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.127692
BRD-A75409952_wortmannin_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DDR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00916551
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2528
BRD-K68162101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23918
BRD-A32595718_CVF-CSC-7 BRD-A32595718_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
339_ANKRD39_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.612173
BRD-K37991163_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K96970199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24442
AURKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00880157
Acute Myeloid Leukemia_LAML_TCGA-AB-3012-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRKDC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00772933
BRD-A20697603_598226_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71644199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82322
SIRT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30091
BRD-K98548675_Parthenolide_CL34_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K52075040_-666_SNGM_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
BRD-K81642886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1967
16863911-table1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K16727544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02873
IPO9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22091
CRCGN017_MCF10A.TP53.M_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24935
UBL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5852
IGR1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53035
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9174
nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.098604
BRD-K46056750_AZD-7762_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CHRM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00641702
2536_EIF2B2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.773971
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78P-01A-12R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2973_FARSA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.560289
DHODH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636063
BRD-A98714080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.92524
PDE1C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00758516
Superior colliculus, motor related, intermediate gray layer, sublayer b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11956
abnormality of vitamin b metabolism	GWASdb SNP-Phenotype Associations	1.0	1.73304
6429_PLD3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.660834
BRD-K68690198_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC5322933-pone.0172430.s013.xls-Oncopath_MSC_Single_Basal_vs_MS-Unnamed_1_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38347298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9886
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_24_human_DRSG_higherRes-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-10_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
496100366_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.47801
BRD-K87909389_alvocidib_LNCAP_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
layer 6 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16385
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.691538
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
YH13	DepMap CRISPR Gene Dependency	1.0	3.19433
ARHGAP15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00738841
3862_HNRNPDL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.580017
3673_HDHD3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.570898
496100516_FWM_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31673
dorsomedial tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05923
4852_MARK2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517505
7176_RBM42_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.756738
Medial amygdalar nucleus, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92437
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal heart morphology	MGI Mouse Phenotype Associations 2023	1.0	null
8563_STXBP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.599559
PARP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0033501
PCYT1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00829466
BRD-K19166598_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BYSL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654341
AOC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00897942
5601_NELFE_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.12454
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6188
UBD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00712493
BRD-K95352812_NCGC00188530-01_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HEATR9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536123
OVOL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6312
BRD-A80383043_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K17008822_BD 1008 dihydrobromide_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intermediate stratum of JcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45935
BRD-A79768653_sirolimus_HCC515_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K50068274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96353
BRD-A06909528_MLS-0315871.0001_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PIGW	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.007753
CFHR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00853858
CRCGN016_MCF10A.TP53.M_24H:B23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28158
BRD-K88573743_A443654_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
1779_COPS3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.624174
carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.054512
TRIM28_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3632_HARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.7258
6720_PRDM10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.791472
5601_NELFE_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.602949
7495_RPRD1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.811771
CEP55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82587
BRD-K30910725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01745
biliary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.276495
BRD-K28120222_Prestw-550_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K35559145_Methotrimeprazine maleat salt_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4761
LYAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00787536
BRD-K24689407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86138
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WT-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15834839_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EMC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.6493
Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.72354
654_ATP5F1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.502728
SKNBE2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55116
Retrosplenial area, ventral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03747
NKX2-5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0110094
GNPDA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57553
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
nutrition disease	GWASdb SNP-Disease Associations	1.0	0.39925
IL17C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574199
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.1747
ZNRF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00549124
HRH3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00795342
NCOR1-26117541-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GCSH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53504
BRD-K24132293_piperlongumine (HPLC)_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
F8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0109034
Posterior parietal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31447
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54166
superficial stratum of r1BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08206
Primary somatosensory area, barrel field	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90269
subpallial amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22647
KP3	CCLE Cell Line Gene CNV Profiles	1.0	1.57117
LAMA84	CCLE Cell Line Gene Expression Profiles	1.0	3.40721
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12502280_TG101348_U937_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K34817515_Fluocinolone acetonide_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K78659596_MLN2238_AGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10351
2537_EIF2B3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.90509
PMC7680901-Table_6.xlsx-both_up_GSE117165-SETBP1_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
PIGU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48871
NFATC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03076
BRD-A51829654_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ADRB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537026
BRD-K53335788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27676
10332_ZNF397_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553132
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041283
Bonemarrow	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
BRD-K43798660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31712
mantle zone of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31845
hsa-miR-514b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Lung squamous cell carcinoma_LUSC_TCGA-46-3766-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K53547009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.98211
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.87407
BRD-K06593056_-666_VCAP_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
602_ATAD5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.577767
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1625
PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74305673_IMD 0354_RMGI_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K17574409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77425
IRAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00988549
6865_PSMD11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.577472
TRPV1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0090428
MORN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00886012
BRD-K47983010_BX-795_EFO27_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
6480_PMPCB_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.51856
H3K4me1_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PLPBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00491749
VMRCLCD	DepMap CRISPR Gene Dependency	1.0	2.57715
BRD-K54979104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08946
2340_DPF1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.523908
KCNJ4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00762286
BRD-K30198800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11645
Perturb_10189_KD_JMJD1C_SRP050058	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.4434
TE11	CCLE Cell Line Gene CNV Profiles	1.0	1.85296
r4 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25078
TE5	CCLE Cell Line Gene CNV Profiles	1.0	2.86863
BRD-K50140147_NVP-TAE684_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Psoriasis vulgaris_Skin tissue_GSE13355	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.38446
Megakaryoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
2535_EIF2B1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513349
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5395
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.606388
VAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3176
layer II of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09867
9837_WDR70_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.681283
bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.374618
LCP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063506
ILF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00600285
BRD-K88418404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43375
layer 4 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.86154
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.30063
Lung squamous cell carcinoma_LUSC_TCGA-56-7579-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31297909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20285
lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.059269
SCN3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00686783
SF3B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0063411
Prostate adenocarcinoma_PRAD_TCGA-EJ-5521-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A19500257_geldanamycin_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perireunensis nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10296
CRCGN014_HEPG2_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19925
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070737
DEF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00855656
Asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
1781_COPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.848668
SLA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00397516
neurodegenerative disease	GWASdb SNP-Disease Associations	1.0	0.291623
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K17743125_S1085_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00755207
BRD-K79551673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.74402
SLC12A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654372
MOSPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08974
Lung adenocarcinoma_LUAD_TCGA-55-1592-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLPI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0049028
Primary somatosensory area, trunk	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08093
NEU	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.045
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900465
cytoskeletal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046167
DACH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00581281
Postsubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55852
Gestational diabetes	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
hsa-miR-3921	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
SYK_knockdown_191_GSE54065	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.9397
BRD-U60236422_WH-4-025_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K80232129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.76767
BRD-A13650332_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A15415227_GW 1929_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0050396
Nonpigmented ciliary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.817
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878048
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Secretory granule membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
intestinal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.590437
BRD-K48056188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45527
Cord blood stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.789
ATIC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536286
MITF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625849
BRD-K52850071_JAK3 Inhibitor II_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF668	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00721614
BRD-K34069025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07266
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet4-RNAseq_SJIA_KD_up_inter_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-125b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K56751279_Y-39983_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MEOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1665
8124_PRELID3B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.693484
ALDH3A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00688675
KU1919	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46092
RUNX1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF514	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.969
GSTA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575697
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bone marrow_CT2_eosinophil	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
KM12	BioGPS Cell Line Gene Expression Profiles	1.0	0.918446
6860_PSMC3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02039
BRD-K68174511_torin-2_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
2446_E4F1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.599371
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
16166288-Table4	GeneSigDB Published Gene Signatures	1.0	null
BRD-A63998256_Helveticoside_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041398
BRD-K00337317_NU-7441_BT20_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878048
narcolepsy	GAD Gene-Disease Associations	1.0	null
BRD-K14618467_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.43798
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.9722
disease	GWASdb SNP-Disease Associations	1.0	0.043888
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EI-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GCH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512748
PSMA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0120061
ZNF285	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49043
Specific granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.757
CCR6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0056043
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.949
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058642
IGSF10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00532316
HBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54714
7328_RNASEH1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.708142
NCI-H2452	GDSC Cell Line Gene Expression Profiles	-1.0	-1.76144
Fc receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.176
polycythemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.332487
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1776
METTL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93219
BRD-K80332123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38061
HCC1143	CCLE Cell Line Gene CNV Profiles	1.0	1.97412
ITGAE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00434105
RPS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00899507
BRD-K30699866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3879
SEC11C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15685
BRD-K03339354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3445
NCOR1	ENCODE Transcription Factor Targets	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-11A-12R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.82641
BRD-K22878149_sb 205607_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
phenylpropanolamine-3217	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
BRD-A65767837_HYDROCORTISONE ACETATE_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CECR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9119
7950_SLBP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03043
5968_ORC4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.677051
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.46085
BRD-K68580555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11426
BRD-A26711594_NICARDIPINE HYDROCHLORIDE_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
8185_SMNDC1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.57456
BRD-A62184259_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8980_TMED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.66047
PYGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15984
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
medial amygdala, anteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10489
BRD-K69468381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14704
BRD-K81322049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63347
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11708
TWIST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.28853
HEL	CCLE Cell Line Gene Expression Profiles	1.0	2.28789
BRD-K95901403_S1118_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SOD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00357894
BRD-K30361950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12044
KYSE-220	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
ULK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519857
BRD-K74694052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72587
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E8-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of TG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58362
SNX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38994
BRD-K30707190_PNU 74654_AGS_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
3566_GTF2A1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548276
BRD-K78559095_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal epididymis morphology	IMPC Knockout Mouse Phenotypes	1.0	null
Primary somatosensory area, barrel field, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.2528
5754_NOSIP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.58998
BRD-K73942403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31304
BCL2L14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00678527
PRXL2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00810474
BRD-A52650764_Ingenol 3, 20-dibenzoate_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A19500257_geldanamycin_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SEMA6C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0057594
NKM-1	GDSC Cell Line Gene Expression Profiles	1.0	1.49495
CEMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6056
GCKR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00557375
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.835694
PILRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613698
TSPAN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.011643
BRD-K92433833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05678
BRD-K91701654_70970_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DAGLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587482
BRD-K53461563_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1436
inner SZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07006
BRD-K98548675_Parthenolide_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BLTP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00489009
UBE2D3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00898182
NACA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00768156
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.79009
ETV2-25802403-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K06399794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36853
FBXO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98298
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KL-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80622162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16197
BRD-K62909525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08998
BRD-K49577636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16281
WNT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613411
BRD-K98161738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49527
BAG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00369059
ZBTB24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566867
BRD-K82928847_rocilinostat_HCC515_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
8885_THEMIS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.808338
HLA-DRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564524
BRD-K79090631_CGP-60474_SKBR3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K89574562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67784
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
EHBP1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00713559
ERN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543881
BRD-K92317137_-666_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NDUFA12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577728
BRD-A80705936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03241
external cortical nucleus of inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20054
BRD-K86930074_S1017_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4862
BRD-K42918627_GSK-2126458_SKBR3_3_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K12502280_TG-101348_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.597615
3632_HARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.808674
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5810_NRDE2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.93622
GFI1_KO_GDS4204_147_mouse_HSC	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
DACH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25179
r6 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66941
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DKK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060848
KY821	GDSC Cell Line Gene Expression Profiles	1.0	1.6542
RAB33A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00805013
BRD-K51843685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13894
BRD-K07259155_NCGC00182362-01_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GPR179	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00386289
2567_EIF4E_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.672887
BAZ1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00847258
BRD-A80775386_GR-237_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A43330902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44838
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09967
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_4day-MOI-10^3_None_GSE43302	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.47377
LIPC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00746149
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.71323
FGL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0073066
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8764
TFE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68062
Perturb_12975_KO_YTHDF2_SRP365416	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
BRD-K05392698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.51971
outer CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.975894
body mass index	GAD Gene-Disease Associations	1.0	null
4683_LRWD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.599971
SNU886	CCLE Cell Line Gene Expression Profiles	-1.0	-1.82536
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68407802_KIN001-055_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bronchus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.104985
BRD-K13146924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06838
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.80776
GATA2_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE94849_3_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45399554_CAM-9-027-3_NCIH508_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DCSTAMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00744104
FASN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00359905
G6PC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537439
superficial stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37334
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MR-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
small intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.391176
Mesonephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.763
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
CUX1	ENCODE Transcription Factor Targets	1.0	null
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A45498368_WYE-125132_SKBR3_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_782_KD_ASXL2_SRP078442	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.19939
9962_ZBED2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507398
Acute Myeloid Leukemia_LAML_TCGA-AB-2874-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bone marrow_CT2_basophil	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
hydrocortisone_homo sapiens_gpl201_gse21909	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K52075715_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CD300LB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00609434
RSL24D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00976481
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A17065207_Brefeldin A_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
XPOT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00425894
BRD-K71430621_clobenpropit_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Taenia tecta, ventral part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.30114
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-RA-A741-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.66409
6798_PRPF40A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.616621
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54673
BRD-K26872015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45056
BRD-K69932463_AZD8055_WSUDLCL2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K63743653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44775
IER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35403
Isocortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2171
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GRM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00412275
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4U1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H727	COSMIC Cell Line Gene CNV Profiles	1.0	4.51153
BRD-A75144621_digoxin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K82217056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04027
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.245685
CDH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566787
Human - Fetal Development - L2 - Heart-CLC_IL5RA positive cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59274
BRD-K46419649_U0126_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RC3H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55941
Lung	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SK-MEL-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33559
IRF1	ENCODE Transcription Factor Targets	1.0	null
BRD-A55594068_VINBLASTINE SULFATE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mantle zone of JcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16298
Cochlear nucleus, subpedunclular granular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47773
L3MBTL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00638396
BRD-K80359388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08928
C1S	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00745897
FKBP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0122901
intercalated amygdaloid nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07177
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058634
OR10V1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0114817
BRD-K81514393_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6958
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.263669
SIRT4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00450905
r10 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05568
ZNF551	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73601
CST3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635034
BRD-K38970027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09679
BRD-K26669427_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-U61997977_WZ-4-145_MDAMB231_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K56653679_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K41859756_-666_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K07061353_7909011_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8124_PRELID3B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509026
NCI-H1666	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K06117861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45052
colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.446558
BRD-K02837259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29035
Prdm14	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.5003
BRD-K41895714_AS-605240_MDAMB231_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K08679933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07604
HSPA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0128762
intestinal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.216325
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7317
hsa-miR-4659a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K28916077_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MTMR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061154
OCI-AML2	GDSC Cell Line Gene Expression Profiles	1.0	2.33119
SKM-1	GDSC Cell Line Gene Expression Profiles	1.0	1.80744
BRD-A28219573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80856
BRD-K16478699_PLX-4720_A375_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WDR45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49866
HIPK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00641177
WHSC1	ENCODE Transcription Factor Targets	1.0	null
10566_ZNF703_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.556227
ZR75B	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.780762
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.22797
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6942-01A-21R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K10705624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18977
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.98775
BRD-K81418486_vorinostat_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_14035_KD_LMNB1_SRP320092	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.76985
HOXA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6864
hsa-miR-542-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.78446
Dendritic cell_Peripheral blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
GNGT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599909
BRD-K73739802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23166
NFKBIE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50366
all	GWASdb SNP-Phenotype Associations	1.0	0.041637
BRD-A75817871_blebbistatin_CL34_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2AC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26536
dorsolateral part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07425
BRD-K51816706_Oxindole I_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.14939
BRD-K52552873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09654
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.834914
NEK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520655
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.62385
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4433
H3K27me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04701596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48391
BRD-K75784474_NCGC00188012-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K79239947_PF 573228_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K98548675_Parthenolide_SW948_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM255A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00699962
BRD-K97056771_HY-11007_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
375_AP2B1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562298
BRD-K40329609_NCGC00184830-01_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K25504083_C8273_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMT5B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0137488
BRD-K47599758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.80192
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22922
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.193285
colonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071905
P2RY8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0061932
289_AMD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.834295
Superior colliculus, optic layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13851
mantle zone of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78044
S100A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00530439
SUGT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.008285
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.61
SEMA3G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00736909
BRD-K41895714_AS-605240_MDAMB231_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
7645_SAMM50_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.851568
TGFB1I1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33031
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-4.10606
BRD-A86109770_Guggulsterone_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K97393725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24337
Organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
HOXA9_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Taenia tecta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23618
MKN7	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57717
regulation of cell cycle	GO Biological Process Annotations 2015	1.0	null
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.449054
BRD-A39747742_ESTRADIOL VALERATE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6867_PSMD13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.530475
superficial stratum of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25034
lung cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062728
BRD-K58547240_7856827_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tectal gray formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23661
IFNA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00724663
OPRM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00770221
Gli2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.1164
7157_RBM14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.729637
BRD-K55044200_amoxicillin crystalline_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TEX101	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0062325
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_13_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3723
dissociates	GeneRIF Biological Term Annotations	1.0	null
Sarcoma_SARC_TCGA-IS-A3K6-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bed nucleus of the accessory olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31252
mantle zone of TG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23917
CEBPD	ENCODE Transcription Factor Targets	1.0	null
BRD-K47869605_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K64881305_S1452_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K21682170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12183
HOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0167
DDI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00589228
1289_CCDC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.569134
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9248
erastin-6369	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RUNX1	ChEA Transcription Factor Targets	1.0	null
LIPT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00686004
STYK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0102284
SF268	GDSC Cell Line Gene Expression Profiles	-1.0	-2.24402
BRD-K08132273_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
bone marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068014
CEBPD_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
501_ARL14EP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.606987
BRD-A19500257_geldanamycin_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_1day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.7882
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.847424
GPNMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491896
hsa-miR-605	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-A80502530_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ADAMTSL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00674095
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32196
BRD-K08043579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02025
CKAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06772
BRD-K84836394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11131
BRD-K07691486_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K59221664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27875
BRD-K01121114_AT-MLPCN CSC-006_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1615
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.67706
BRD-A19500257_geldanamycin_OV7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
Kidney Chromophobe_KICH_TCGA-KN-8431-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CIT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552379
KCNJ14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00534528
C99	DepMap CRISPR Gene Dependency	1.0	2.99901
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7840-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25433859_maprotilline hcl_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.39215
FTCD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00421945
H3K27me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WDR72	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0101136
5810_NRDE2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07186
BRD-A29009894_AZD-1480_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CDKN2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18954
MXI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.24138
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19576
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.94153
BRD-K12184916_-666_NCIH508_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11708
VPS72	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00810337
2244_DLST_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.641035
TRMT10B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84624
BRD-K37764012_PF-3758309_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TMEM163	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00464637
GSE212330_1_v_0_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67512
outer CP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06733
glaucoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.18651
3134_FOLR3_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04646
antazoline-3173	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LILRB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572395
BRD-U82589721_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PTGER2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0068701
BRD-K54814515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69538
superficial stratum of AOV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26368
RFX5	ENCODE Transcription Factor Targets	1.0	null
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3023
BRD-K52695588_NCGC00188714-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cord blood stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.829453
MAGED1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00638286
KDM6A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00661466
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049219
Anterior olfactory nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05374
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-A94756469_DIGOXIN_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.497657
BRD-K02822062_CT-200783_WSUDLCL2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cSARS Bat SRBD_54Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.36477
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.63607
6006_OXA1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.581558
deferasirox_homo sapiens_gpl570_gds3558	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCDC87	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6947
Anteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08644
IFNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00517455
TIGD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15069
MOS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00783122
BRD-A30758703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04231
zonal layer of SC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13138
BRD-K76938712_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K96704648_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FLI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00692363
OLIG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0383
BRD-K72414522_AZD-5438_MCF10A_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YR-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OSM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00725651
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K88569143_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A13122391_16-HYDROXYTRIPTOLIDE_SKMEL28_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45057266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54974
BRD-K23282736_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CDK2	Pathway Commons Protein-Protein Interactions	1.0	null
PNPLA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00709586
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.10719
VEGFA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00708779
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.82396
GSE211267_1_v_0_trim21_human	RummaGEO Gene Perturbation Signatures	1.0	null
SPOCK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00808358
2501_EFR3A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564084
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
BRD-K37846922_GR-207_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.638914
BRD-A45333398_PERIPLOCYMARIN_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
3371_GINS3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.696935
TNFAIP8L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0064253
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-A26095496_CLOBETASOL PROPIONATE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TNKS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0109827
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.2088
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5681-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KCTD16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00812403
5969_ORC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.620301
ALDH18A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00380085
DPF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480484
BRD-K86867503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38733
BRD-K42191735_buparlisib_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet3-RNAseq_SJIA_KD_inter_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4632-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFYVE19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75053
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7161_RBM17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552333
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.43163
534_ARPC1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.14703
IFNG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528806
hsa-miR-4653-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE132408_1_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE131649_4_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.8877
BRD-K70057550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.85247
496100555_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.35028
SLC1A7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00393993
CSF1-CSF1R complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.821
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70149
BRD-K41859756_-666_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
1152_CAD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.834454
BRD-K05409106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33381
Ventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44819
TEAD4	ENCODE Transcription Factor Targets	1.0	null
BRD-K26122955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58042
BRD-K22915992	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78184
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.461
CRELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49323
Cytoneme	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.774
4152_INTS7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.53821
9212_TPRKB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.675181
BRD-K52075715_OXIBENDAZOLE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K95014129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11295
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.231
6748_PRIM2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503623
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.5882
BRD-K04534322_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PPIB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00747834
BRD-A72711497_LASALOCID SODIUM_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BTG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00778321
1469_CEBPG_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.836823
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7380-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7166_RBM25_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.535201
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05382
BRD-K58547240_7856827_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
1779_COPS3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.700614
SELE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0111237
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
hsa-miR-3148	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GABRQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99516
BRD-K39985369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93929
skeletalmuscle	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.29242
CRCGN014_HEPG2_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04374
BRD-K60507178_Podophyllotoxin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.848953
COX7C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00557344
U118MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.90294
SIN3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0092825
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0087
8703_TAZ_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.620913
MFE296	DepMap CRISPR Gene Dependency	1.0	3.61664
BRD-K02778241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51131
NCIH716	CCLE Cell Line Gene CNV Profiles	-1.0	-2.41574
5910_NXF1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.504161
WWP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89614
THBS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.010788
8425_SRRM2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.54664
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DB-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YWHAE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79824
KAT2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00439843
cell part	GO Cellular Component Annotations 2015	1.0	null
2536_EIF2B2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.642083
BRD-K18619710_Digoxigenin_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lateral ventricle	HPA Tissue Protein Expression Profiles	1.0	0.70149
BRD-K93483334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50971
BRD-K80786583_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ACAD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588718
BRD-K87982677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2871
MOB3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00704311
ARID3A	ENCODE Transcription Factor Targets	1.0	null
vitamin b12 deficiency	GWASdb SNP-Disease Associations	1.0	1.81431
Histiocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.446
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15743
KLRK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0060383
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-common-common_genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_NB4_HL-60_and_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31889
BRD-K60907484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24634
IST-SL2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K97274161_N-{2-[benzyl(isopropyl)amino]ethyl}-4-({[(4-methylphenyl)sulfonyl]amino}methyl)benzamide_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PCSK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98768
GSE131649_2_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KE39	DepMap CRISPR Gene Dependency	1.0	2.87833
2678_EPRS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.540444
PRSS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566591
Kupffer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.377
SKN3	DepMap CRISPR Gene Dependency	1.0	3.17395
8545_STT3A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.588555
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
CHRNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00579354
1230_CBX3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.902097
BRD-A97437073_Rosiglitazone Hydrochloride_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PIM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00954575
7188_RBMX_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.583529
BRD-K35240878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04498
hsa-miR-185	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
SLC4A11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551706
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
BRD-K44103530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05088
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.044266
HAO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628946
6861_PSMC4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.581251
BRD-K43639523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17188
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8094
MLLT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91003
layer 5 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01779
BRD-K24051260_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PIK3R4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0030796
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
1939_CTNNBL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.896408
5933_OGT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.769778
BRD-K16518464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17977
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A216-11A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDK12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628568
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.68786
PHF8	ENCODE Transcription Factor Targets	1.0	null
GSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9408
BRD-K40175214_torin-1_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GABRG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582336
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.7573
COG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060508
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22991
BRD-K22322324_5120-0434_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A22783572_Vinblastine sulfate_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MLPH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574501
BRD-K53414658_tivozanib_HEPG2_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K01815685_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K99252563_QL-XII-47_HME1_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PITPNM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0067729
perinuclear region of cytoplasm	GO Cellular Component Annotations 2015	1.0	null
BRD-K67007076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68496
5968_ORC4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.733948
11008_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.04785
UHRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28941
CTSS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00780717
BRD-K61463582_GR-239_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.05671
GABPA	ENCODE Transcription Factor Targets	1.0	null
CD48	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00708853
S1PR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00447499
BRD-K40175214_torin-1_LNCAP_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
2315_DNMT3A_ENST00000402667.1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.514928
GSE152441,GSE152442_0_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77621
ITPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654076
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067754
BRD-K44483161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70552
HOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9614
Pleural cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
BRD-K63068307_S1072_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GRIA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00769909
GSE217776,GSE217829_1_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	1.0	null
CA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00842923
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16587
GPN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00634027
PDCD10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494194
BRD-K96438475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2961
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.73258
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_3Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.60002
BRD-K95712112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00585
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7924-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00770194
ZBTB32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00516033
Skin	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
KCNJ8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0072988
NSUN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90969
BRD-K79131256_albendazole_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
specific granule	GO Cellular Component Annotations 2025	1.0	null
MESP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13206
1844_CPSF6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.687183
MEOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.637
NR2F2	ENCODE Transcription Factor Targets	1.0	null
PFKFB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00847377
PAX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00766153
WholeBlood	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.864606
BRD-A19500257_geldanamycin_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964219
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AF-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DCP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22866
septal organ	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.08055
G6PD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00610392
ACTR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056878
NFE2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01562
KCNU1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636451
ITGB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00369414
BRD-K12035825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19795
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
SCARB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543238
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33978
LMNB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41803
cerebellum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.958834
BRD-K91239327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04315
SLC39A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00854593
BRD-K47109712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58395
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044157
BRD-A19500257_geldanamycin_AGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K22087390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85049
Severe acute respiratory syndrome (SARS)_Peripheral blood mononuclear cell_GSE1739	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.32137
BRD-A95442017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49842
Primary somatosensory area, barrel field, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19045
HCN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00536706
8373_SPRY1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504734
SLFN11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00762429
Primary somatosensory area, barrel field, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.04391
A_CA_04_2009_7dayMOI-10^3_None_GSE37569	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.30546
metabolic	GAD High Level Gene-Disease Associations	1.0	0.295739
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9924
BRD-A01593789_CHLORMADINONE ACETATE_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BtuCD complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.86
BRD-K70487031_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-5398-01A-02R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF695	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67286
enlarged heart	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K09523238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2597
PON1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617083
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5131
LN340	DepMap CRISPR Gene Dependency	1.0	7.63588
GPR25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00835408
BRD-K05402890_17757146_HA1E_24.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1696
BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K70116387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05236
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.701253
PIM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0067411
r5 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.77958
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NMRK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.008077
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23264
RNASE6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585671
KCNB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0071372
BRD-K91900765_S1458_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25141
ventral subnucleus of MG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2624
AMY1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00739125
BRD-K23327891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07322
H3K9me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.288
RERE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1023
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-0.888279
BRD-K48046422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28781
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.201
731_B3GNTL1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.749727
SP140	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622495
TRPC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00709926
lung fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.128352
HLA-DRB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00530458
8166_SMG5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.690554
BRD-A95513702_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CYP2C8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00641087
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01429
Ebolavirus(ZEBOV)_1hr_Macrophage_22028943_GSE31747	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.37776
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4P0-01A-41R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AV-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100526_TCx_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14242
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1677
Pheochromocytoma and Paraganglioma_PCPG_TCGA-PR-A5PF-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A84702196_penicillin v_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
16652140-Table2	GeneSigDB Published Gene Signatures	1.0	null
reticular formation of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03853
BRD-K81277520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01946
Lung adenocarcinoma_LUAD_TCGA-55-6975-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64800655_HY-11001_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A08191729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06996
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.865284
NPHS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566993
CRCGN017_MCF10A.WT.HP_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1243
BRD-K51575138_TPCA-1_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14487
BRD-A36151937_Genistin_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A74134989_Structure possibly contains amino acid derivative which is not supported in current version!_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E6-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A19500257_geldanamycin_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.77635
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2812
ZNF365	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00507405
5902_NUP88_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563405
3980_HSPA9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.14289
BRD-K07160586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0056
2173_DGCR2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.536761
BRD-K15891719_T018500_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00779318
IM95	DepMap CRISPR Gene Dependency	1.0	10.8231
CYP11A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00679108
BRD-K25710391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75447
BRD-K19220233_JNK-9L_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ANGPTL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00811264
RUNX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00514356
BRD-K07303502_Arachidonyl trifluoro-methyl ketone_NCIH1836_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K09878843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.4093
BRD-A19500257_geldanamycin_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A51B-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24422491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22393
6890_PSPH_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.787741
SKMEL2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92708
colonic epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.248361
Core mediator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.811
BRD-K30707190_PNU 74654_PC3_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CLDN11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00547921
SLC13A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00567356
4250_JAZF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.554723
NCIH226	DepMap CRISPR Gene Dependency	1.0	7.00584
CDK18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0101051
MST1R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00840857
MDA-MB-231	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K68174511_torin-2_MDAMB231_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9787
hsa-miR-4641	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
IRF6_01_101	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.14967
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00944
1786_COPS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.549759
superficial layers of TG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31761
BRD-A09719808_NCGC00188536-01_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Blood_CT2_basophil	HuBMAP ASCT+B Annotations	1.0	null
Primary somatosensory area, upper limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11817
GNMT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0100654
inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046396
PWWP3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62611
8669_TAF7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.804653
8918_TIMM17B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.579898
BRD-K81651477_Parthenolide_NCIH2073_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DUSP16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549706
NNMT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00525519
BRD-K53026281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19275
1268_CCDC174_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552885
CARD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0109935
Carcinoma, Squamous Cell	HuGE Navigator Gene-Phenotype Associations	1.0	null
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.83727
KLRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04204
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.35
BRD-K76205745_Losartan Potassium_RMGI_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
8772_TCERG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.677431
GATA1	ENCODE Transcription Factor Targets	1.0	null
3_AACS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.61238
Primary motor area, Layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02142
ZSWIM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05762
BRD-A68865339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15433
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6258
PMC11401508-NIHMS2019525-supplement-2.xlsx-Sheet1-SP1_candidate_repressors_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
SPRY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0129782
PMC8088646-13148_2021_1081_MOESM1_ESM.xlsx-ST12-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068812
BRD-K57182060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9081
9601_UPF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.724234
Diphtheria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
9426_TUBGCP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.37415
Primary lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.802
7823_SETDB1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.29423
KCNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632061
neoplasms	GeneRIF Biological Term Annotations	1.0	null
TANK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00741605
ZDHHC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11158
BRD-K24132293_piperlongumine (HPLC)_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intralaminar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19232
BRD-K06980535_PROMAZINE HYDROCHLORIDE_MDST8_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Blood_CT2_basophil	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
TMEM52B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0118373
BRD-K05471809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35619
C8B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00692416
BRD-K74399971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.448
BRD-K36737713_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CSAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00611546
BRD-K38358574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41792
dorsalrootganglion	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
NCAPG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00773488
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EA-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.16315
Nucleus of the trapezoid body	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00526
BIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00774651
BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_RMGI_6.0_h_6.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18190982_COT-10b_U937_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PRKAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64492
BRD-K61323504_SB 225002_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Neutrophil degranulation	Reactome Pathways 2024	1.0	null
2520_EHMT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.614651
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72034681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39641
HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4938
5658_NFYC_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.54369
Essential tremor 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.086
Retrosplenial area, lateral agranular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16959
BRD-K59955428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03962
PMC10248509-Data_Sheet_5.CSV--GSE66724_DE-Genes_AND_GSE41177_DE-Genes_NOT_Autophagy_NOT_GSE58294_DE-genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
2031_DAXX_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.703933
BRD-K37328981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8499
skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
TFPI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0061682
BHMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9015
MOLM13	CCLE Cell Line Gene Expression Profiles	1.0	1.43157
714_AURKA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.660754
BRD-K30326216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35141
BRD-K26734305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06628
MKS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.9
adrenal gland	HPA Tissue Gene Expression Profiles	-1.0	-0.888279
MMP23A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00796656
Body Mass Index	dbGAP Gene-Trait Associations	1.0	0.227193
5501_NCKIPSD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.980556
HDAC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00411542
Thymoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.918
retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.119331
HEL9217	DepMap CRISPR Gene Dependency	1.0	2.60001
RHOH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00513279
PILRB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0047052
BRD-K09146396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84212
PMC9894241-pnas.2211429119.sd05.xlsx-G7_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051287
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
HOP-62	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52709
BRD-K93034159_2-chloro-2-deoxyadenosine_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K34387287_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8759131-advancesADV2021004469-suppl2.xlsx-Table_S1-Supplementary_Table_1_Differentially_expressed_genes_post_knockout_of_MEF2D_in_MOLM-13_AML_cells_MEF2D	Rummagene Transcription Factor Associations 2026	1.0	null
7929_SIRT7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.795586
U138	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.05576
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-7_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
subpretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26665
BRD-K30707190_PNU 74654_MCF7_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DGKE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0107289
GPR132	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614597
HCC2218	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27611
6798_PRPF40A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.840938
4653_LRPPRC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509438
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.133
periventricular stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.07166
BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_RMGI_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.75131
Brain Lower Grade Glioma_LGG_TCGA-HT-A5RB-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60483981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14816
BRD-A56592690_PX12_MCF7_24.0_h_30.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r10 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10018
Flocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43489
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC7A14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00952687
6860_PSMC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.796744
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5739
BRD-K28346421_rifapentine_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PDK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4033
STAT5A_02_182	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.6094
Ltk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
BT474	CCLE Cell Line Gene CNV Profiles	1.0	1.76041
b-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.408592
inner CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.874895
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_13_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K08845546_FK506_NCIH1694_6.0_h_22.2_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K49061529_ETHYL-beta-CARBOLINE-3-CARBOXYLATE_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K04192407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02085
C1QTNF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45542
amygdalostriatal transition area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07346
CATSPER1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660015
Anteromedial visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23791
CSF1R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00616863
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A84695402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78832
Chronic myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059144
neurological	GAD High Level Gene-Disease Associations	1.0	0.293278
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.71983
BRD-A72703248_SKF 96365 hydrochloride_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.994439
actin cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.234891
facilitates	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6828-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4703-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K25737009_-666_HCC15_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72316
olfactory part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20264
BRD-K78599730_manumycin A_SKMEL1_6.0_h_9.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PDK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490605
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
HOXB7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4506
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.633924
PSMB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621619
XCL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00895851
GSE182680,GSE182683_0_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8190596-mmc2.xlsx-ETV6_mut-ETV6_mut_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.598
BRD-K64800655_HY-11001_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Gizzard	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
BRD-K68174511_torin-2_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GALNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82219
dorsal pallium/isocortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28765
specific granule membrane	GO Cellular Component Annotations 2023	1.0	null
8426_SRRT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.887
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.600735
PMC11309649-medi-103-e37185-s002.xlsx-Sheet1-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
hypothalamic amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57552
CML - Chronic myeloid leukemia_Haematopoietic stem cell_GSE11889	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.95004
BRD-K93747373_HG-5-113-01_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NREP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625408
FCRL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00880545
BRD-K67950754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78369
heart muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.888279
BRD-K19220233_JNK-9L_SKBR3_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STK19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00802822
SF295	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59059
BRD-K81418486_vorinostat_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A770-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1351_CCT7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.593479
navicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.14024
BRD-A22713669_BVT 948_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MXD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00705837
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.1219
PMC8755441-mmc3.xlsx-IRF1-UP-mono_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K42506600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94471
medial amygdala, posterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11817
RHOV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00594977
PCK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00707894
ZACN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00597516
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19983
6981_QARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.643322
FDXR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490487
BRD-K11589884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10115
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
BRD-K70511574_S1485_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PIK3C2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81232
BRD-K37906141	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24444
BRD-K89278382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20392
BRD-K05002317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62758
CDKN3	Pathway Commons Protein-Protein Interactions	1.0	null
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3019
BRD-A80574334_13521_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pernicious anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.60147
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.468
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.199993
IP6K2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490663
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.19726
16140871-SuppTable7	GeneSigDB Published Gene Signatures	1.0	null
5266_MRPS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.512571
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K57282030_JW-7-24-1_MDAMB231_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
1780_COPS4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.936699
BRD-K66032149_VU0365117-1_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BICRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49341
BRD-K90049800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46487
PLA1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0103376
CNR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00901522
PHF19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543794
MMAA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00637076
BRD-K36852613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07845
BRD-K73402542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4469
TGM2_KD_GSE23702_716_human_NB4 cells, 72h ATRA-induced differentiation	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K99859971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18155
LDHC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00989018
BRD-K77884956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3736
KCNJ5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00754703
PTDSS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85252
rhombomere 11	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71478
BRD-K39733634_L 161982_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC22A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00741224
BRD-K92428232_HY-50877_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Taenia tecta, ventral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.00601
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.105725
BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
BRD-K98772859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52592
CCDC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15518
8669_TAF7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533257
TACR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00705121
BRD-K29418729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46886
EoL-1-cell	GDSC Cell Line Gene Expression Profiles	1.0	1.51932
5762_NPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.898156
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.3486
Myelocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.088
2539_EIF2B5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.647877
ocular hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.708364
abnormal heart morphology	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K34106082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41763
GSE147366_3_v_2_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.298165
thymus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.13909
KCNQ4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00579216
UBTFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22889
5600_NELFCD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.573887
Brain Lower Grade Glioma_LGG_TCGA-WY-A85C-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary somatosensory area, barrel field, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.86154
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07693
Bronchial Hyperreactivity	DisGeNET Gene-Disease Associations	1.0	null
EM2	CCLE Cell Line Gene Expression Profiles	1.0	1.58933
PL21	CCLE Cell Line Gene Expression Profiles	1.0	2.04874
Chronic myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.256
SETDB1	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-4609-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144500_8_v_2_ventx_human	RummaGEO Gene Perturbation Signatures	1.0	null
SPINK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620618
BRD-K96560179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67943
PRAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0052053
UNC119	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664121
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
Cortical amygdalar area, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1785
SPI1-20176806-THIOMACROPHAGE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE185519_6_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
inner CP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25058
SKRC20	CCLE Cell Line Gene Expression Profiles	-1.0	-2.14932
organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045697
BRD-K83898111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28173
BRD-K31912990_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K42253676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09893
ITGA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00547798
lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.074536
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9811
BRD-K93537437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46463
5908_NUTF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.982149
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.07646
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6818
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SYNCRIP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512334
294_AMMECR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.653531
ALPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563229
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01001
Cobalamin transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.888
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_MCF7_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K98408839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40209
PMC9904760-elife-79363-supp2.xlsx-MDS1-Gene_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071884
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.45403
smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.310783
BRD-K54099984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27563
BRD-K63606607_bufalin_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K05236810_Luteolin_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K75252192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27384
CDON	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58217
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8734
hsa-miR-620	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Perturb_728_OE_QKI5_SRP293637	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A4TM-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00662134
BRD-K81528515_nilotinib_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Blood-cd24 neutrophil	Tabula Sapiens Gene-Cell Associations	1.0	-0.23073
NAT8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0075138
CHCHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90448
BRD-K36111748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01555
POU2AF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0102453
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9895
NB4	CCLE Cell Line Gene Expression Profiles	1.0	1.59768
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00989
BRD-A52794651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05575
SDF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00714367
BRD-K94012289_OSI-027_SKBR3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.995193
ORMDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43218
DUOX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0071463
LRAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595301
BRD-K42728290_NVP-BGJ398_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K06408981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.56437
BRD-K39815998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11496
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFKB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622954
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26648
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1509
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.6886
specific granule	GO Cellular Component Annotations 2023	1.0	null
BRD-A54927599_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7330-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
19549311-SuppTable2-MMLandPhenotype	GeneSigDB Published Gene Signatures	1.0	null
BRD-K49371609_528116.cdx_HA1E_24.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
1780_COPS4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.564866
BRD-K75410936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7195
RBM15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30269
7389_RNF34_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.601483
BRD-K05197617_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.500699
BRD-K44432556_VU0418946-2_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OCIAML3	CCLE Cell Line Gene Expression Profiles	1.0	1.4791
chronic myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.432608
BRD-K28195874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00418
GSE76425_0_v_3_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2789_EXOSC2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.60032
BRD-K53417444_OTSSP167_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A06276885_N-Benzylnaltrindole hydrochloride_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GJB7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00625942
BRD-A75421526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22696
amino acid metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.166768
BRD-K74402642_Chemistry 2804_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC39A11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00999102
Chronic asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
Lung squamous cell carcinoma_LUSC_TCGA-22-4596-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K45252063_Clofibrate_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-DX-A2J4-01A-32R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A59145032_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JMJD6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00579003
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32016
K-562 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.243
BRD-K00914921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48909
BRD-K23363278_CYT997_HA1E_24.0_h_1.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2778-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NME4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00836533
MBD3L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65319
9641_USP21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.518411
MAST4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0102151
TIFAB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00556555
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H82	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6819
PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S12-ZNF384_DiffExprGene-Unnamed_1_ZNF384	Rummagene Transcription Factor Associations 2026	1.0	null
JOSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00043
GSE131649_6_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATP13A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36777
fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076282
Cytoplasmic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.688
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.099
PRSS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00630763
BRD-A48237631_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
R3HDM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00957792
BRD-K92317137_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer 1 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34537
AML193	CCLE Cell Line Gene Expression Profiles	1.0	1.85351
BRD-A22783572_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cervix uteri	GTEx Tissue Gene Expression Profiles	-1.0	-0.898998
BRD-K54233340_Dorsomorphin dihydrochloride_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
9475_U2SURP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516107
CCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00604698
BRD-K53417444_OTSSP167_MCF7_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K27540772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35272
fourth ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.260267
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055594
BRD-K33200274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.63354
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MP-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.9792
hsa-miR-23b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
CRCGN016_MCF10A.TP53.M_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05575
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08547
YDJC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623038
RNASEH2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00976293
CHD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00580369
EVSA-T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MRPL36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04811
JHESOAD1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.7057
hsa-miR-1912	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.1893
RAGE_knockout_268_GDS3755	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.39685
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6849_PSMB1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532129
colonic cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074085
P2RX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00630031
PDE4D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00807414
Arid5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.0423
ABC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.67591
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1507
Primary somatosensory area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.50107
NEK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00610512
BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE150055_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
CNFN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04028
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27743
hsa-miR-4486	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A1A1-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
APEH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00732734
MYC	ENCODE Transcription Factor Targets	1.0	null
PARP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61415
CD160	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614518
PKIA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00883138
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WM1799	DepMap CRISPR Gene Dependency	1.0	2.03982
Retrosplenial area, lateral agranular part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33533
BRD-K03176945_7910663_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1061
NLGN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1096
PRDM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05036
SLAMF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613109
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.52556
SUSA	DepMap CRISPR Gene Dependency	1.0	2.96989
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NIM1K	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00731511
Prostate adenocarcinoma_PRAD_TCGA-CH-5763-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9894241-pnas.2211429119.sd05.xlsx-G8_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
496100357_TCx_no dementia_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.60565
BRD-K80786583_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SCD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00594174
cephalothin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65266
PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Baboon_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-RP-A693-06A-13R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral parabrachial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04678
BRD-K69496360_7831785_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8214_SNIP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.523177
BRD-K52075715_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K73858940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54125
BRD-K81647657_3-methyladenine_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
NFKBIZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00717897
BRD-K08940439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03194
TAL1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7032
SEMA3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90969
5658_NFYC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.748501
BRD-K11636097_S1249_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K17896185_FIT_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
XRCC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00425276
TRAPPC13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00583892
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.739999
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0587
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.573
HCE4	DepMap CRISPR Gene Dependency	1.0	4.40402
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.087202
JPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21551
Somatosensory areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.38807
6856_PSMB7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.554012
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.876664
zygote	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.281776
4273_KARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.50471
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27743
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.607
IZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.88313
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05539
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18601
ARVCF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97977
BRD-K47618355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04309
BRD-K13086002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1169
BRD-K72636697_QL-X-138_BT20_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6854
THP1	DepMap CRISPR Gene Dependency	1.0	4.05056
HEPACAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00521393
BRD-K93747373_HG-5-113-01_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8264_SOCS3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.686173
H1-8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71125
TOB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0084004
Perturb_13502_KD_WDR5_SRP321449	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.36893
LB647-SCLC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.804604
BRD-K09854848_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Alzheimer's disease	GWAS Catalog SNP-Phenotype Associations	1.0	0.220915
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059747
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.789039
TIMD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00535209
SLR21	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56331
GSE152441,GSE152442_6_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nutritional deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.223509
CEBPA-26348894-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
7950_SLBP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.96215
CORL105	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62767
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-697_elements_included_exclusively_in_HIF1_genes_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A90289676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67191
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046014
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5273_MS4A3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.689702
Primary somatosensory area, unassigned, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4044
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.423818
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
BRD-A93236127_DIGITOXIN_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CMPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00535655
3369_GINS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16772
BRD-K00615600_AG14361_H1299_6.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K16570418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28737
SETD1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35411
HPS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00771461
NPM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00999722
ESCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5642
TESK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00597808
DTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61969
16144796-Table4	GeneSigDB Published Gene Signatures	1.0	null
BRD-K67200393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19707
BRD-K31805261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07799
1893_CSE1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.50568
8692_TARDBP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500957
BRD-K84709232_Caffeic acid phenethyl ester_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.10508
SNAI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00877837
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.283295
19837975-TableS1	GeneSigDB Published Gene Signatures	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.50301
BRD-A55484088_BNTX maleate_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NY-05A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.556
GJB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00477068
BRD-A19962819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.89271
hsa-miR-509-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
FBXW11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065783
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JDP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00837361
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0556
Leukemia	DisGeNET Gene-Disease Associations	1.0	null
645_ATP1A1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.992255
HRH4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00837896
ICAM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00403086
BRD-K86995890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27483
6135_PCNA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.632511
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.43
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31059261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40256
BRD-K32037893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03382
BRD-A49765801_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K88378636_withaferin-a_BT20_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A22032524_AMLODIPINE BESYLATE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K68143200_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K22701871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45479
BRD-A07861932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.81947
3654_HBS1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.795187
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K75618633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14555
MS4A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00548782
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.041855
BRD-K23029982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9493
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00605548
DCUN1D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00820827
Wheezing	DisGeNET Gene-Phenotype Associations	1.0	null
KLF7_KO_GDS2069_68_mouse_olfactory epithelia	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.137932
r11 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73396
Primary somatosensory area, lower limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.31698
16109776-TableS1	GeneSigDB Published Gene Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2175
BRD-K08316444_-666_HT29_24.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49138
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7102
lymphoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071735
Promyelocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.783
FLCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52863
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20138377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26543
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.925988
20371479-TableS2	GeneSigDB Published Gene Signatures	1.0	null
C12orf43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4751
Postpiriform transition area, layers 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05568
BRD-K10987837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19812
968_C12ORF60_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.612341
BRD-K04853698_LDN-193189_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_11934_KD_AKR2_SRP286031	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9337
2427_DYNLL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.604616
APOBEC3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00680243
BRD-A00267231_HEMADO_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K17349619_HLI 373_COV644_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
stratum oriens of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01518
GALNT10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00727411
BRD-K25504083_C8273_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF580	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.47541
BRD-K03857568_1-Methyl-3-nitro-4-p-tolylsulfanyl-1H-quinolin-2-one BRD-K03857568_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K19930413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50917
beta-N-acetylhexosaminidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.29
MELHO	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38045
OE21	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37035
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16587
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Specific granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.182
6319_PIAS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.887124
BRD-K84937637_A-275_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K12184916_-666_WSUDLCL2_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595574
BRD-K77634326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77129
6850_PSMB2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.775046
BRD-K09638361_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A85231803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5341
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.97057
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27743
GSE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02416
LRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00982093
612_ATF7IP_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.944515
BRD-K58892587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07305
Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
salivary gland	GTEx Tissue Gene Expression Profiles	-1.0	-1.10081
CARM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494346
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
IL12A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620378
TRIM46	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598474
G6PC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00656437
SGF29	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00887866
9316_TRMU_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538466
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0974
COLO678	CCLE Cell Line Gene CNV Profiles	-1.0	-2.00148
TSHR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00837384
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50000283_PHA-767491_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ACO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00702195
BRD-K25868508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01421
TTBK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00634558
Prostate adenocarcinoma_PRAD_TCGA-CH-5745-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CXCL13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00607611
BRD-K57782577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27291
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cortical amygdalar area, posterior part, lateral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08276
BRD-K64770897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26575
Mesothelioma_MESO_TCGA-LK-A4O4-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K53417444_OTSSP167_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
granulocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.147867
hsa-miR-582-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
2238_DLD_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.29593
lung fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220831
BRD-A20697603_T8902_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PU.1-20176806-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-A5NK-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GHRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567353
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GATA3-21867929-TH1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52224
nuclear membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.18516
BRD-K81795824_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K21313369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08751
Lateral tuberal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.576
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A58955223_L-sulforophane_RMUGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPS6KC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00657154
KG1	CCLE Cell Line Gene CNV Profiles	1.0	1.53501
leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.061419
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-5_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K21718444_KW-2449_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A79768653_sirolimus_SKBR3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GRK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00848779
Bone marrow	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
CDH3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00468199
KCNK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00576064
BRD-K64742599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02641
BRD-K49669041_HY-11005_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K12040459_AT7867_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
9412_TUBB2A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.730058
PMC5903287-NIHMS956886-supplement-Table_2.xls-THP1_THP3_cds_exp_down-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GJB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0103427
CRCGN017_MCF10A.WT.HP_24H:K16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.271
BRD-A98283014_C3930_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K03816923_ROTTLERIN NCGC00025228-11_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-M30523314_V2264_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2661-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ICOS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00497178
LYST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567844
GSTM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00607503
CALHM6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0053889
BRD-K14812927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78607
FXN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00382764
BRD-K52163391_NCGC00165208-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K60692685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55752
BRD-A30435184_Metergoline_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RCC4	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68489
BRD-K24132293_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6517_POLD3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.562901
7893_SEM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.650552
dorsal subnucleus of MG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.423
H3K9me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE144500_8_v_6_ventx_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4512-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KCNJ10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00675828
BRD-A19500257_geldanamycin_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37441
BRD-K79259477_KIN001-265_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC5322933-pone.0172430.s013.xls-HG_MSC_Single_Basal_vs_MSC_AD_B-Unnamed_1_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51576
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.83542
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.341
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
1425_CDK13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.651306
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K67844266_MLN4924_SW620_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K11373525_ZD 7155 hydrochloride_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RTEL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00574365
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5685
peripheral blood stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.221061
1709_CNIH4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544756
AATK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00717875
overnutrition	GWASdb SNP-Disease Associations	1.0	0.462498
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32016
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
1893_CSE1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.40801
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0458
9399_TTI2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.760569
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.33107
BRD-A98203122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22767
RGS5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00838088
GFUS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30239
BLTP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40252
DCAF13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00661586
NUAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00665243
BRD-K35491869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61234
3369_GINS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.19116
2989_FBRSL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539138
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.405935
377_AP2M1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.97535
BRD-K67478255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03127
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
651_ATP2C1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.826194
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13223
BRD-K88573743_A443654_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.054557
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8237
BRD-A23723433_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ML-2	GDSC Cell Line Gene Expression Profiles	1.0	1.90489
igh2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.368
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
RYR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539306
BRD-A24396574_celastrol_BT20_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KCNJ15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00650734
BRD-K55679243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0288
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8411-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.258016
16740760-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
OVOL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9847
BRD-K02927989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00326
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.391
Postpiriform transition area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2994
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7617
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964219
BRD-K84987553_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NFATC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00410959
FBXL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530299
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
Vitamin B12 deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
BRD-U51024685_HG-6-64-01_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K18518344_Digitoxigenin_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NELL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00907699
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
7795_SERF2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.11612
Primary somatosensory area, upper limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33533
NCI-H1915	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A3HE-01A-21R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06765193_5663823_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAFF	ENCODE Transcription Factor Targets	1.0	null
8431_SRSF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.769123
BRD-K16943897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0604
BRD-K19817946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79454
HOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1682
PMC5322933-pone.0172430.s013.xls-Immune_MSC_Single_Basal_vs_MSC-Unnamed_1_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
CD177	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00870817
MTHFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00965342
HUS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602316
645_ATP1A1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.536932
1782_COPS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.75367
PES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30078
SNU182	CCLE Cell Line Gene CNV Profiles	1.0	2.66593
BRD-A19500257_geldanamycin_HS578T_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3634
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FCGR2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575971
LHCGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00674091
1532_CFDP1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.509005
9435_TUT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512814
Nucleus of the lateral olfactory tract, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30994
GSK3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00624237
Autosomal dominant intellectual developmental disorder 22	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.689
U937	DepMap CRISPR Gene Dependency	1.0	2.10221
BRD-A43575461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27328
5038_MGAT4B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.14523
ZDHHC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00998
Fbxl10_OE_GDS4788_580_mouse_fibroblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069913
TRIM28_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
TAF5L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00779424
NCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502
UACC893	DepMap CRISPR Gene Dependency	1.0	3.6138
TM31	CCLE Cell Line Gene CNV Profiles	1.0	1.43864
BRD-K99545815_HY-10459_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0342
Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.2557
BRD-A83124583_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0104875
seminiferous tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.19299
Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052742
HCC1395	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6449
HOXA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3653
enhances	GeneRIF Biological Term Annotations	1.0	null
BRD-K49865102_S1036_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MFSD10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00654976
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K64800655_PHA-793887_A375_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K76431854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1416
M14	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52398
Koelliker-Fuse nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10221
superficial stratum of AHy	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57552
6861_PSMC4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.515738
BRD-K53903639_480743.cdx_PL21_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K53972329_CT-INCB_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K15409150_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCIH2073	CCLE Cell Line Gene CNV Profiles	-1.0	-2.14116
BRD-K72296840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74721
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07084
FIBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00715492
Lung adenocarcinoma_LUAD_TCGA-62-A46R-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00461534
BRD-K08036779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55121
BRD-K95037415_NCGC00167094-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Taenia tecta, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.77701
MAPKAPK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0032816
BRD-K25737009_-666_MCF7_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SETD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00476457
BCL2L10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84519
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069976
BRD-K01436366_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TKFC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00661162
BRD-K73418978_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MPP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0123278
DPP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608137
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	1.0	1.45257
Lung squamous cell carcinoma_LUSC_TCGA-56-7730-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cytoplasmic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
skeletal muscle	HPA Tissue Protein Expression Profiles	1.0	1.09761
PMC3572987-pone.0056308.s001.xls-EVI1_regulated_genes-GENE_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
OVOL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0108743
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1081
H3K4me1_CD34 Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K36583698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15736
7062_RAD21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.518909
kap	GeneRIF Biological Term Annotations	1.0	null
MAP3K8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543211
NR5A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00847738
MFSD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66015
TPD52L3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00646766
EWSR1_KD_GDS4962_465_human_Ewing sarcoma and prostate cancer	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
8578_SUGT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.918447
borderline glaucoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.708364
Anteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66669
CIP2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00731669
5236_MRPL52_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505736
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.78558
8816_TELO2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.599433
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56595
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TTLL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42308
BRD-K21680192_mitoxantrone_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Super elongation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.644
UACC812	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.781642
NCR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567054
BRD-K64890080_BI-2536_HS578T_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC4487811-mmc3.xlsx-siRE_enriched_geneLists-siRE_occupancy_pattern_gene_lists_after_RUNX1_ETO_knock_down_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
CA11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00808071
SNU13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00976706
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MMACHC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00780548
THY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00863885
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.17066
BRD-K54112192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47835
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042217
BRD-K97534490_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K03816923_Rottlerin_VCAP_6.0_h_9.68_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PANX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00606409
lens	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.218398
CDKN2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00533747
posterior paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33686
SUDHL5	DepMap CRISPR Gene Dependency	1.0	2.32067
PMC6962646-mmc2.xlsx-StemCell_Genesets_2018-GSX1_GSX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7219112__F7	PFOCR Pathway Figure Associations 2024	1.0	null
FN3KRP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00316757
BRD-K50704115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38852
BRD-K33583600_ISOLIQUIRITIGENIN_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.730696
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056785
PROX1_01_06	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60698
abnormality of vitamin metabolism	GWASdb SNP-Phenotype Associations	1.0	0.398408
BRD-K07061353_7909011_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KIT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0194659
BRD-K29905972_S1005_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
7496_RPRD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.781166
CORL279	CCLE Cell Line Gene Expression Profiles	-1.0	-2.03899
BRD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00761227
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05465
RGS7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00758398
Spleen-intermediate monocyte	Tabula Sapiens Gene-Cell Associations	1.0	0.725151
Ciliary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.538
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-PHOX2B-fromNode_PHOX2B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A38030642_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K45421483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.437
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
obstructive lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.205916
BRD-K94629607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11278
629_ATIC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.691423
CRCGN008_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6351
DAGLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70395
BRD-K96263742_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RSL1D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00444767
r11 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73396
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.532413
Lung squamous cell carcinoma_LUSC_TCGA-22-5472-11A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60794504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45769
1161_CALR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.65278
LB1047RCC	DepMap CRISPR Gene Dependency	1.0	2.61507
HTR6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00607631
CDC42EP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28326
BRD-K98731749_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K65752097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12058
HDAC6	ENCODE Transcription Factor Targets	1.0	null
GJB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00838534
IKBKG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0074139
2367_DPY30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.688919
MEIS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70747
BRD-K19540840_HY-10234_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
kapcdk2cyclin	GeneRIF Biological Term Annotations	1.0	null
BRD-A55594068_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CCL11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00851469
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BLTP3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00915793
BRD-K15591233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.57583
periventricular stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.08045
ORAI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00715029
BRD-K77417197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0514
ATP4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520283
BRD-K15282657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20417
HPCAL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01646
POLR2G_02_130	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60282
bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.119122
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1769
BRD-K09854848_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC4A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00981
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7058-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8475
mantle zone of AOV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26325
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.312988
BRD-K68336408_tyrphostin-AG-1478_PC3_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
IL11RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00545945
BRD-A34806832_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K21680192_mitoxantrone_HT29_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K57382977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-6.50263
core-binding factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.178
S100A9 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.674
6856_PSMB7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.57997
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8495
GLUD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.005494
Lung squamous cell carcinoma_LUSC_TCGA-43-6773-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
dephosphorylation	GeneRIF Biological Term Annotations	1.0	null
IFNA14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00387079
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2193
BRD-K78431006_HY-50878_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC25A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00469393
PMC3470785-NIHMS377161-supplement-3.pdf-632-SREBF2_SREBF2	Rummagene Transcription Factor Associations 2026	1.0	null
HL60	CCLE Cell Line Gene Expression Profiles	1.0	1.45376
SHP77	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81838
BRD-K56224420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05069
Erythroid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.737
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAGI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00534387
BRD-K94452277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41023
3567_GTF2A2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.652829
SLC25A37	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0112726
BRD-K17140735_-666_MCF7_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RO60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66146
9215_TPR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.607849
TGFB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00617049
mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063149
BRD-K41303952_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K08109215_I-BET_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STAT6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00477779
Lung adenocarcinoma_LUAD_TCGA-44-2666-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K33860558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38072
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072253
CISD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00445472
BRD-K91701654_70970_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Myeloid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.774
BRD-K98437821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7855
3823_HMG20B_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.633045
INPP5K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13974
BRD-A10188456_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2419
TWF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628611
Acute Myeloid Leukemia_LAML_TCGA-AB-2897-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1844_CPSF6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.10878
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6218-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
471_ARHGAP6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.619485
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5721
CXCL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00776705
COX5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56579
ADCK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566155
BRD-K10573841_T7765_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K79376287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05547
ABCA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0068272
BRD-K69492024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30603
BRD-K74148702_curcumin_NCIH1694_6.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K50894381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52173
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2648
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Combined-MYB_Combined_sgRNA_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.261245
697	DepMap CRISPR Gene Dependency	1.0	5.87018
TF1	CCLE Cell Line Gene Expression Profiles	1.0	1.38111
BRD-K49328571_dasatinib_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
EARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00867
hsa-miR-4530	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K14599588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5169
Lhx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.093
BRD-K84881516_Thiophene-2-carboxylic acid benzothiazol-2-ylamide MLS-0446110.0001_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A87C-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TNFRSF9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0108799
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.9151
CTCF	ENCODE Transcription Factor Targets	1.0	null
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05374
PSKH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00442821
Medial septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45382
BRD-K18909381_cgs 12066b_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IGR39	CCLE Cell Line Gene CNV Profiles	1.0	1.79426
BRD-K42308740_ST056792_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JEKO1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63824
2186_DHDDS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.12642
TENM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563502
GM97	BioGPS Cell Line Gene Expression Profiles	1.0	0.959706
1175_CAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.588004
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.00268
EZH2	ENCODE Transcription Factor Targets	1.0	null
PDE6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00775323
BRD-K64890080_BI-2536_MCF10A_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SPTBN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20678
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5985-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary motor area, Layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24553
BRD-K46056750_AZD-7762_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K11928012_NCGC00182913-03_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TBX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00396897
BRD-K90284572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79794
TCIRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60988
NFATC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523985
superficial stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66807
BRD-A49447682_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K82109576_vincristine_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
9479_UBA2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.50038
GSE120612_6_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19220233_JNK-9L_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GLUL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00904268
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55362
BRD-K21064560_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16587
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.19801
SMIM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0103558
2633_EN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563444
Flocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32058
NDUFA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00854838
SNU738	DepMap CRISPR Gene Dependency	1.0	2.19307
immune	GAD High Level Gene-Disease Associations	1.0	0.293278
BRD-K05474024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01438
PCID2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0070491
PINK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0073166
10202_ZNF207_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.578041
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
NPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81711
BRD-K12884811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51221
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39897
medial pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33728
Prostate adenocarcinoma_PRAD_TCGA-KC-A7FE-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LSM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0050745
NPY2R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00594744
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06834
HIPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00647985
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061675
SW1990	DepMap CRISPR Gene Dependency	1.0	5.22894
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
Subiculum, ventral part, stratum radiatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38422
Brain Lower Grade Glioma_LGG_TCGA-DB-A64L-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE131649_2_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A87137733_GSK-690693_BT20_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6111
E2F7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00827377
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K42496940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24506
PLAGL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00671247
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.558583
EP300	ENCODE Transcription Factor Targets	1.0	null
BRD-K06792661_Narciclasine_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-A34205397_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Megakaryocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.48
Perturb_13501_KD_WDR5_SRP261594	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
3370_GINS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.532617
BRD-K45609222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.01849
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HC-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
HCC1419	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
SLC4A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00729417
BRD-K61909412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.48607
BRD-A37959677_ESTRONE_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12055596-41375_2025_2570_MOESM4_ESM.xlsx-PDX1-Unnamed_14_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73O-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KNS60	DepMap CRISPR Gene Dependency	1.0	2.6331
SIRT5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646461
BRD-K88677950_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8185_SMNDC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.973088
CRCGN010_HEPG2_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30581
BRD-K56343971_PLX-4032_RMGI_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K03554945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08999
medial geniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23618
BRD-A52193669_2816_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.249329
490_ARID3A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.501241
5869_NUDT21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.644202
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K77947974_Fluspirilen_HT115_6.0_h_4.21_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
3370_GINS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.53389
BRD-K97183783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04664
BRD-K65639003_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Human - Bone Marrow - L2 - Basophil Eosinophil Mast Progenitor	HuBMAP Azimuth Cell Type Annotations	1.0	null
BRD-K35708212_-666_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DTX3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89652
BRD-K42436189_AZ20_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
2678_EPRS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.856478
BRD-K65261396_F4679_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PELP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00407209
BRD-K23361743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00015
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.852657
BRD-K12079898_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CHRM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00474647
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06755
LSM6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00767775
NDC80	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00560138
NEUROD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00914149
RCOR1	ENCODE Transcription Factor Targets	1.0	null
CUL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00712883
BRD-K46056750_AZD-7762_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K06096379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18758
BRD-K64800655_PHA-793887_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8018-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ADRA2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00439727
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0114
BRD-K81418486_vorinostat_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
SPI1-20176806-THIOMACROPHAGE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CREB1_01_04	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.37249
CYP24A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00986671
IRAK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00944111
bone	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
BRD-K67844266_MLN4924_HT29_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Ventral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06632
IRF1-21803131-MONOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
VPS26C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00721149
BRD-K35687265_S1362_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K15863674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07153
9606_UQCC2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.527724
Egg	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.591
SFXN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00925507
ZNF101	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58361
Vitamin B12 levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.45229
GRPR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0070123
Secretory granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
testis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.146395
WNK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00488965
8793_TCP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.702866
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8001-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9600_UPF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.613318
ACTR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00905018
hsa-miR-4795-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
SBK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0107063
CRCGN017_MCF10A.TP53.M_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36187
OFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30376
SIRT6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00698515
Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065405
NADK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00770048
BRD-K88573743_A443654_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K25979535_8009-6730_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2882
eosinophil	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.283191
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D5-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49328571_dasatinib_HS578T_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3421-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Vitamin metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.349
Pancreas_CT2_Neutrophil	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
abnormal epididymis morphology	MGI Mouse Phenotype Associations 2023	1.0	null
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.792
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
REST	ENCODE Transcription Factor Targets	1.0	null
6517_POLD3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.43528
BRD-K10207760_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539668
261_ALDOA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.528407
SARS-BatSRBD_Day7_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.69086
VSTM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00658042
Secretory vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TIGAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00559776
STK33_SKM	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
hsa-miR-1245b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
TUBG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00872118
ZNF254	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48574
A498	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48106
DOT1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495252
BRD-K91271834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24268
P31-FUJ	GDSC Cell Line Gene Expression Profiles	1.0	1.98597
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S18-Table_S18_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-002_4H_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
r3 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32871
PMC11647701-JHA2-5-1243-s008.xlsx-RUNX1-Gene_Name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
LNZ308	CCLE Cell Line Gene Expression Profiles	-1.0	-2.15023
inner CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00035
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.0621
BRD-K49328571_dasatinib_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ARID2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00710389
PIKFYVE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00952953
BRD-A20213616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.73385
Primary somatosensory area, lower limb, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56373
non-small cell lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.085254
BRD-K19645475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1635
Specific granule membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
IFI6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00670356
BRD-K99749624_S1003_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GAA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2612
SART1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00741731
Perturb_10147_KO_FAM122A_SRP235545	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.10927
BRD-K64881305_S1452_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K30707190_PNU 74654_NCIH2073_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4644	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
PADI6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0078888
BRD-K49810818_S-8599_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KLHL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540573
BRD-K33104513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20267
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.995193
IDH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598444
P31FUJ	CCLE Cell Line Gene Expression Profiles	1.0	1.71454
TNFAIP6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00758761
KYSE-150	GDSC Cell Line Gene Expression Profiles	-1.0	-1.69056
tm-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.622639
BRD-A22783572_Vinblastine sulfate_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
9703_VARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.589873
332_ANKRD17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.10031
KIF5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00686845
SLC47A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00814103
LTB4R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00527812
ulcerative colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.446558
GSE229580_2_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	1.41884
colonic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07231
8940_TK1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539739
Cortical amygdalar area, posterior part, lateral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3705
TEAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2897
H3K27me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A-Netherlands-602-2009(H1N1)_0Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.09172
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3026
BRD-K78659596_MLN2238_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K87909389_alvocidib_SKBR3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K08489825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00348
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.98575
AIRE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82072
TSC22D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69558
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05238
CLCNKB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602674
BRD-K06344882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03072
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.34509
CAMK1G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0062875
BRD-K16472144_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Primary somatosensory area, mouth, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78754
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bone marrow_CT2_mast cell	HuBMAP ASCT+B Annotations	1.0	null
mantle zone of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90218
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.2944
ZNF692	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96087
hsa-miR-23a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
CYP19A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00855443
BRD-K48899005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.6548
BRD-A50454580_Axon1408_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OLIG3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3294
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SET2	CCLE Cell Line Gene Expression Profiles	1.0	1.49472
hsa-miR-875-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
15902281-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
TEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5274
k-562 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.456828
BRD-A45498368_WYE-125132_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_10192_KD_AML1ETO_SRP149373	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
vorinostat_homo sapiens_gpl6947_gse41504	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
bile duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.121199
NDUFB5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067758
GSE201309_5_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K56287385_ST001903_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PTGIS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0107253
BRD-K97470305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64724
gastrointestinal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068522
CRCGN015_HEPG2_48H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3569
TXNIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36776
Basolateral amygdalar nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35283
176_AFG3L2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.605993
BRD-K47983010_BX-795_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K84401063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04954
SNRPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00995275
496100303_HIP_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0173
OSCAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00844965
BRD-K08806317_s(-)-timolol_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
skein-like inclusion	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.509
SIGM5	CCLE Cell Line Gene Expression Profiles	1.0	1.54273
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053442
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878048
actin filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.407919
1504_CEP350_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.625172
PMC11696763-41598_2024_79298_MOESM7_ESM.csv--Table_S1_Differentially_expressed_genes_including_ZNF560_were_screened_out_between_normal_and_tumor_tissues_ZNF560	Rummagene Transcription Factor Associations 2026	1.0	null
5493_NCBP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.2003
Liver reticuloendothelial system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.354
LTC4S	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00883492
TNFSF13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00713888
SCC9	DepMap CRISPR Gene Dependency	1.0	4.09929
VSIG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00435408
BRD-K47217000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15225
CIZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63529
BRD-U86922168_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MIF_DEPLETION_GDS3626_95_human_HEK293 kidney cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NOLC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00518169
BRD-K91810283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01032
BRD-K54507743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24448
BRD-A38030642_cyclosporin A_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081682
HOXA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00425706
ASPM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53386
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LC4-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MMUT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635729
KIR2DS4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00693512
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43865
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.29905
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070659
ERMAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00951707
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1897
anterior olfactory area, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26368
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.286
5494_NCBP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.14135
bone marrow	HPA Tissue Protein Expression Profiles	1.0	1.09761
SLC19A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490528
7814_SETD1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.598211
t-lymphoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.229032
BRD-K00259736_Colchicine_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K05804044_AZ-628_HT29_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RDES	CCLE Cell Line Gene CNV Profiles	1.0	1.47288
5955_OR4K1_ENST00000285600.4	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.67452
TXK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060243
CD180	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00647038
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2953
BRD-K13169950_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K47635719_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hindbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078243
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3909
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K04853698_LDN-193189_HS578T_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K83972459_JWE-035_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2189
BRD-A39969961_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23393
Lung adenocarcinoma_LUAD_TCGA-05-4389-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9663
BRD-K13390322_AT-7519_SKBR3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Medial geniculate complex, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14428
BRD-K65887908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4444
CXCL6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652916
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12619
BRD-K98444789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41369
7785_SEPTIN2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.545895
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04092
adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.194232
dementia	GWASdb SNP-Disease Associations	1.0	0.383074
Lung squamous cell carcinoma_LUSC_TCGA-22-5478-11A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47983010_BX-795_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ADAD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00541976
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051047
CYP2D7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00596039
hsa-miR-3127-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067095
BRAF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0102102
KU812	CCLE Cell Line Gene CNV Profiles	1.0	1.33364
BRD-K34685430_Methylergometrine maleate_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.785
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.947617
9324_TRPM7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.827831
H2BC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00478
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.67521
BRD-A79465854_auranofin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE185519_1_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CBFB_01_43	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.62449
CD19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585951
BRD-K83562499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27608
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-RELA_DN_V1_UP-Gene_name_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-4659b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K69337311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27371
2389_DTL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.704653
LMX1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46887
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
NPPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054668
HNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53777
testicular cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.227445
GUK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00928458
DNPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93831
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.22923
parastrial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41054
BRD-A68631409_Evodiamine_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mantle zone of LAP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0196
BRD-K44100512_KIN001-043_HEPG2_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K44432556_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RNPEP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00437368
MYB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42898
SRRT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00769698
6792_PRPF19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.996772
ANKRD13C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55664
BRD-K42125900_S1148_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K52522949_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SCC15	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4819
skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZR751	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56207
10136_ZMAT2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52883
H3K9ac_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
UBE2E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48559
BRD-K83270677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15169
BRD-A47109850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49361
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
FAM13A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00595687
ALDH3B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00516241
binding	GO Molecular Function Annotations 2015	1.0	null
Primary visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01063
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A50737080_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FES	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00672816
BRD-K93578426_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K12244279_MEK1/2 Inhibitor_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
jejunum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.207636
SLITRK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68817
BRD-A39996500_radicicol_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K21196859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06041
BRD-K10435664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11267
MZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.92244
9398_TTI1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.614613
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2711
BRD-K59507567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46639
BRD-K70401845_erlotinib_MCF10A_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GNA12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00801508
lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066955
1545_CHAF1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.50017
STK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567844
medial amygdala, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.26526
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CL-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7631_KD_AF4_SRP078067	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.47986
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71989
Prostate adenocarcinoma_PRAD_TCGA-J4-A67K-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5ST-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K99252563_QL-XII-47_LNCAP_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3133
ACSL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56063
7823_SETDB1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	2.03353
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041025
HEPACAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00794206
SP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.917044
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040802
cdk2	GeneRIF Biological Term Annotations	1.0	null
MCHR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00684869
18510698-Table2	GeneSigDB Published Gene Signatures	1.0	null
MVK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00496306
SLAMF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00984734
BRD-K83820627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51061
MYB-21317192-ERMYB-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K34954550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47344
cycle	GeneRIF Biological Term Annotations	1.0	null
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067048
lateropallial amygdalopiriform area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01591
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6777
Rectum adenocarcinoma_READ_TCGA-EI-6885-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.994439
Primary somatosensory area, lower limb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11009
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050702
NECTIN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00789439
BRD-A89434049_SARMENTOGENIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DBP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.216
BRD-K60870698_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZEB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00692308
PDE8A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00408639
GGT7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0107763
PIK3R5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00469201
9107_TMOD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.671232
CRCGN012_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40364
BRD-A30083233_NP-007374_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer 2 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29058
H3K9me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SULT1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11071
PTGIR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0100124
5966_ORC2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.899406
r2 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00703
SKMEL28	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69159
BRD-K88200990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85515
BRD-K30799912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03814
BRD-K25737009_-666_HT29_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TAL1	ENCODE Transcription Factor Targets	1.0	null
BRD-K12879624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63072
BRD-K25504083_C8273_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lassa Fever Virus_8hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.83805
8426_SRRT_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.69297
BRD-K39688447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44094
CASP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00615413
abnormality of the vitamin b12 metabolism	GWASdb SNP-Phenotype Associations	1.0	1.73304
BRD-K15616905_CCCP_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NDUFB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00965676
USH1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34581
BRD-K87669982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80335
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.7144
1570_CHERP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.602209
IRF1-21803131-MONOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
SST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570512
TEAD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A76528577_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K93752373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.96307
CGB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2514
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046483
SHMT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00646326
ACVRL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677029
2203_DHX15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.741566
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A23359898_sibutramine_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CEP43	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00611117
BRD-K22670776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07608
BRD-K73459389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50882
SPATS2L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0077867
r4 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.24397
HEKTE	CCLE Cell Line Gene Expression Profiles	-1.0	-1.59655
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MALME3M	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6194
BRD-K92479346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11654
BRD-K39345836_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K62970326_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.877
respiratory mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.167998
PYGM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00669295
893_BRD8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.546052
Retrosplenial area, lateral agranular part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19232
NDUFB8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00764342
PGRMC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00269313
SUPT7L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.008885
EZH2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hematopoietic cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
2336_DONSON_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.632609
RAVE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.001
NCIH3255	CCLE Cell Line Gene Expression Profiles	-1.0	-1.82879
BRD-K05350981_oligomycin c_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.83839
BRD-K03093950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74224
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.605
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4174-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fbxl10_OE_GDS4788_327_mouse_MEF fibroblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K23478508_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K49577446_flunisolide_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K50474387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06843
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.7823
BRD-K12306640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15756
BRD-K35960502_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE120612_4_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K22134346_simvastatin_RKO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sarcoma_SARC_TCGA-MB-A5Y9-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BTNL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00548734
XCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00605963
BRD-K38248167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1318
BRD-A58955223_L-sulforophane_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DUSP1_Deficiency_GDS1606_765_mouse_Spleen	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964219
Primary somatosensory area, trunk, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33353
BRD-K64800655_PHA-793887_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventral part of JcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16298
ITPKC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00431118
PAFAH1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79393
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7245-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
thymus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.180018
SOX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9211
Tertiary granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.027
BRD-K62533881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42715
pleura	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.193271
SMARCA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01711
NRAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00779849
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45190659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85314
3372_GINS4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.29044
KDM1A	ENCODE Transcription Factor Targets	1.0	null
BRD-K45062933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23683
ARAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14169
periventricular stratum of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.57425
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878048
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2036
TGFBR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0136857
BRD-K03736784_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Tertiary granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.758
BRD-K86998514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16837
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-HL-60-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_HL-60_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
6138_PCNX3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.57048
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.9085
Rectum adenocarcinoma_READ_TCGA-AG-3902-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K27354087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07202
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	2.03533
MEF2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516862
SIGMAR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537414
BRD-K87316858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09303
6351_PIK3C2A_ENST00000265970.7	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539239
obesity	GWASdb SNP-Disease Associations	1.0	0.876818
r3 part of ventral parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15038
BRD-K10649245_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC36A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00769537
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.884742
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83W-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05326558_2-(1,3-Dimethyl-2,6-dioxo-7-propyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-N-(4,5,6,7-tetrahydro-benzothiazol-2-yl)-acetamide_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ELOF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647385
GABRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462686
BRD-K75130046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35885
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.769717
Skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4511
SCLC21H	CCLE Cell Line Gene Expression Profiles	-1.0	-1.89616
7188_RBMX_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.545106
BRD-K78867378_mw-A1-12_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CXCL8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0085157
BRD-K55722623_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K26767475_NCGC00183255-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FGFR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00616658
BRD-A64290322_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
5619_NF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.775749
BRD-K54233340_Dorsomorphin dihydrochloride_NCIH2073_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A11095214_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KASUMI-1	GDSC Cell Line Gene Expression Profiles	1.0	1.44269
granular layer of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.872774
BRD-K98173387_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.104195
Leukemic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.017
BRD-K14109347_LY2603618_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K18787491_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RUNX1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K63547380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45656
BRD-K25931705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48964
1109_MTRES1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.612098
NCIH650	CCLE Cell Line Gene CNV Profiles	1.0	1.49211
TRIP10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00369137
UCMA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89114
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.116033
embryonic fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.100237
CYP20A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00655075
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.865284
Gestational Diabetes	DisGeNET Gene-Phenotype Associations	1.0	null
trichostatin A-3227	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IL1RAPL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00775103
SLC52A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00684609
ATP11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56851
16652140-Table3	GeneSigDB Published Gene Signatures	1.0	null
BRD-K10906552_7887507_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5163-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SENP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0266
midbrain reticular formation	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.861339
BRD-A43155244_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6777_PRMT5_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.854401
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.50892
nucleus	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-A17635048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.14311
18818702-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
8750_TBX1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.557414
MOGGUVW	DepMap CRISPR Gene Dependency	1.0	2.4661
FOSL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00711952
BRD-K14618467_IKK 16_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PTGDR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00659814
5356_MVD_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01295
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K54233340_Dorsomorphin dihydrochloride_OV7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Innate Immune System	Reactome Pathways 2024	1.0	null
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5255
BRD-K31342827_GF-109203X_HT29_24.0_h_12.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FABP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00656941
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NFS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00369723
BRD-U64521890_XMD16-144_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EM-2	GDSC Cell Line Gene Expression Profiles	1.0	1.58967
Spleen-hematopoietic stem cell	Tabula Sapiens Gene-Cell Associations	1.0	2.69449
HNRNPCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63707
BRD-K18194590_MEPHENTERMINE SULFATE_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
3654_HBS1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.543887
MV411	CCLE Cell Line Gene Expression Profiles	1.0	1.91708
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44377
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5888-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.178
ATP8B4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0054913
CCL18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0079823
DRAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00383479
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
SERPINI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00944849
BRD-K56343971_PLX-4032_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0041
BRD-K30318008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.94768
BMP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00867803
gizzard	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.390421
BRD-K75857911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.64011
BRD-A20242387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11318
HEL9217	CCLE Cell Line Gene Expression Profiles	1.0	1.75398
9703_VARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.715229
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.9217
CTSB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00445421
BRD-K34604755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37065
BRD-K71870778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88795
CAMK1D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647281
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4777
BRD-K39120595_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ACADSB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00627962
Bone marrow_CT2_mast cell	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
STRADB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00688737
K-562R cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.69
BRD-A35588707_TENIPOSIDE_THP1_6.0_h_1.25_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8427-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7529
3634_HAUS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.808658
BRD-A72066420_SR 202_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
C2CD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10494
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT5A_02_72	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.64442
hsa-miR-4684-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
CELF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35214
4152_INTS7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.975537
FAM86C2P	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2546
GSE162623_0_v_1_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K55187425_ON-01910_A549_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TLR7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575171
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98684188_G5797_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.262304
biological regulation	GO Biological Process Annotations 2015	1.0	null
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.4151
PIK3R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063867
786_BCAS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.35506
BRD-K56836463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28293
STAT5A	ENCODE Transcription Factor Targets	1.0	null
BRD-K66413698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30648
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Ventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
CCDC85B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509329
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.834914
204_AHCY_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.664187
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
BRD-A36010170_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRYBB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00513955
GSS	CCLE Cell Line Gene CNV Profiles	1.0	1.43637
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4666
1778_COPS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.09973
BRD-K84937637_A-275_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Superior colliculus, sensory related	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03935
BRD-K60781525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57666
DVL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0040136
BRD-K41895714_AS-605240_MDAMB231_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PRSS16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0097669
4371_KIAA1958_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.08589
8520_STK32C_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.839503
Granular lamina of the cochlear nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.25142
BRD-A90643929_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRR14L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00436319
HCC364	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51293
el-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.388158
GSE199204,GSE211619_4_v_7_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0873
retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.086593
OR5B21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00911814
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
BRD-K18036262_L-168,049_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_753_KD_ABAT_SRP385901	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
allergic asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.668742
CAL72	DepMap CRISPR Gene Dependency	1.0	2.39958
S1PR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608582
hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.216933
SHARPIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0045138
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058138
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878048
MAP2K4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00538277
DNAJC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97685
4863_MAT2A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.80105
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65676
HNRNPH1_02_08	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.67945
1206_CASP8AP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09806
DDC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00436294
PCDHB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61382
HDAC2	ENCODE Transcription Factor Targets	1.0	null
BRD-K22185032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33775
bone marrow	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4823
JAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16874
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CI-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bile canaliculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.535833
PM20D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595692
BRD-K30707190_PNU 74654_HA1E_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STK39	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00728619
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BIRC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00514584
CRP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00799767
9548_UBR5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.635311
hsa-miR-23c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE152441,GSE152442_0_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K20742498_RS 39604 hydrochloride_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
10244_ZNF260_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.933525
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.620084
MNX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.738
RPL26L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00709966
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92937
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5405
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EX-01A-12R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7457_RPL29_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520164
MAPK14_KD_GDS2693_533_mouse_A431	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4317
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.44551
superficial stratum of the PBC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04596
SLC7A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00495238
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86411
KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K48029790_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MONO-MAC-6	GDSC Cell Line Gene Expression Profiles	1.0	1.80263
bleomycin-sulfate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89522
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61250553_Loperamide hydrochloride_NCIH508_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3974	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
hsa-miR-1200	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
6480_PMPCB_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.525855
BRD-K13049116_BMS-754807_RMGI_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K33204113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88219
ASCL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03841
ACTA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00557935
RIEG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00516912
RIOK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00895041
EHMT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00651494
terfenadine-1381	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A69512159_carbidopa_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K96799727_-666_RKO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GM1600	BioGPS Cell Line Gene Expression Profiles	1.0	1.135
SIGIRR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00388493
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2761
ATP8B2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00604119
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
DUSP1_KO_GDS1606_775_mouse_Spleens	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CDK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00348914
TH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00498682
KCNN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0065275
BRD-K69097969_VU0418939-2_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_12940_KO_YBX1_SRP321707	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K64763786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36624
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6758
superficial stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23747
BRD-K75746738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16908
MDAMB175VII	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72
7814_SETD1A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13074
USP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00842595
STK33	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
ZDHHC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47365
Posterior parietal association areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24168
BRD-K44494409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04252
alzheimer disease	GWASdb SNP-Phenotype Associations	1.0	0.656005
IL21R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561052
BRD-K54879095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0459
BRD-K37387086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74735
superficial stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.13709
hsa-miR-383	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
p2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.718
AK8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00671223
FOXP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0062477
BRD-K21064560_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.24838
5263_MRPS34_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.706448
FGF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521891
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7671
bone marrow	HPA Tissue Gene Expression Profiles	1.0	2.24804
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.876664
BRD-K74402642_Chemistry 2804_DV90_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PLD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16858
hsa-miR-1290	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-K48950795_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RD	CCLE Cell Line Gene Expression Profiles	-1.0	-1.96231
ATM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569251
BRD-K78659596_MLN2238_SKMEL28_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27743
8008_SLC25A42_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.718557
STAMBPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.006208
BRD-K53903639_480743.cdx_AGS_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.213
10016_ZBTB9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504847
NKRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93395
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.13736
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900465
Vitamin B 12	dbGAP Gene-Trait Associations	1.0	1.20587
HIF3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646866
POU2F2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0105152
SAP30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91125
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63175663_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC2A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587908
proteasome regulatory particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.306632
BRD-A99518825_STOCK4S-23872_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.63
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.862074
BRD-K21036759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89798
BRD-A54927599_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K52075040_-666_PL21_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN008_HEPG2_24H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6798
NIHOVCAR3	DepMap CRISPR Gene Dependency	1.0	4.85794
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT5A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71823332_S1297_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K13879491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06229
1187_CAPZB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540949
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.7773
BRD-K32318651_acyclovir_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ciliary epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.601283
hsa-miR-1262	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
thymoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.405678
MMP28	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00656147
SKP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44159
BRD-A07875874_Cilnidipine_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8065
BRD-A77216878_manumycin A_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DDX21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.004974
TUBB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00695453
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28143534_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Thymic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
8678_TAMM41_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.520227
5494_NCBP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.749222
BRD-K37456065_VU0365114-2_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K54686062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47534
BRD-A28746609_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K44227013_ponatinib_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SERPINA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553626
377_AP2M1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.514438
BRD-A19633847_PERHEXILINE MALEATE_OV7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
6865_PSMD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552893
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.87981
DOK	DepMap CRISPR Gene Dependency	1.0	3.68091
SH10TC	DepMap CRISPR Gene Dependency	1.0	2.26177
r3 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87034
Uvula (IX), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00279
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ovary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066017
BRD-A19500257_geldanamycin_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KLF1	ChEA Transcription Factor Targets	1.0	null
3531_GRB2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.59499
Adrenocortical carcinoma_ACC_TCGA-OR-A5KT-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5903287-NIHMS956886-supplement-Table_2.xls-THP1_THP2_cds_exp_down-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03736784_-666_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
3531_GRB2_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.536863
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4472
496100426_PCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.36157
CACNA2D2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0100324
CBLB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00484465
mantle zone of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.82914
PRKACG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00950201
Primary somatosensory area, mouth, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01063
TM4SF5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540936
CEBPD_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16533489_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K89997465_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K85965830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03396
Paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4243
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05233
BRD-A34806832_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
prednisolone_homo sapiens_gpl570_gse32962	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5933-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6794_PRPF38A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.04476
Acute Myeloid Leukemia_LAML_TCGA-AB-2877-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K97514127_vinorelbine_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
parietal cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.83535
BRD-A36630025_-666_U937_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K50140147_HY-10192_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2238_DLD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.6422
Asthma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K21568472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41226
CRCGN014_HEPG2_3H:M03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15278
BRD-K12502280_TG101348_PL21_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2644
MYBPC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00889988
SETDB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00508706
BRD-K53281329_SYK-inhibitor_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K53903639_480743.cdx_NCIH1836_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070664
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057593
N4BP2L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00733578
BRD-K79254416_decitabine_A375_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
S100A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76555
BRD-K65955264_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K79179851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54147
bronchoalveolar system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072262
6214_PELO_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.697083
MYB	ChEA Transcription Factor Targets	1.0	null
HINFP	JASPAR Predicted Transcription Factor Targets	1.0	null
DPP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.322
Human - Fetal Development - L1 - CLC_IL5RA positive cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
1605_CHTF8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564173
HERC5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00556307
MAK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602008
CHP212	DepMap CRISPR Gene Dependency	1.0	2.12439
DMS114	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39766
BRD-K02822062_CT-200783_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
1785_COPS7B_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.643625
TRPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00934787
VEGFC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00636699
YMB1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58353
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	1.0	6.88956
ZIC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73269
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.176357
MT-ND4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28111
BRD-K51643438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17601
TUBB2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88885
SYK_druginhibition_154_GSE34176	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.18898
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900465
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8122
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-8121-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DNAJC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13568
BRD-K11362964_5235244_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3483
HTR2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00872126
BRD-K83213911_PF 750_LOVO_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K79090631_CGP-60474_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TMF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585365
BRD-K44432556_-666_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TSPO	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00932786
CACNA1G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544824
PLOD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00673923
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8787
GRK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558313
BRD-K27476975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22377
BRD-K45628030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40962
1578_CHML_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.819705
CRCGN017_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51075
OPRD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00919308
ACTR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00370156
HOP62	DepMap CRISPR Gene Dependency	1.0	2.35096
Bipolar Disorder_frontal cortex_GSE5388	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.48603
BRD-K81810589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23521
BRD-K84320538	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21678
PPP1R13B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36815
TLCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2262
8618_SYF2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.85748
hsa-miR-3653	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
NDUFV2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73625
BRD-K09434518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4591
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.526432
BRD-K79877849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21972
GART	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49183
open-angle glaucoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.403438
BRD-K30649484_4-(aminomethyl)benzenesulfonamide_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HMCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554825
6920_PTP4A2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.17924
CHD1	ENCODE Transcription Factor Targets	1.0	null
BRD-K46017542_NCGC00241435-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K33272502_DG-041_SKMEL28_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ART3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00961321
TLR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0077551
Superior colliculus, superficial gray layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1018
1349_CCT5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.179
SNU475	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68176
BRD-K36228696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44168
hsa-miR-4420	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3261
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.878048
BRD-K12539581_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
2366_DPY19L4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.09519
LDHA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00454471
BRD-K47635719_Dexamethasone acetate_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K40876208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00856
1255_CCDC130_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.552176
EPHA10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0108604
BRD-K69387464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52163
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13498
Anterior cingulate area, dorsal part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01063
BRD-K52924481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.91008
BRD-K78524708_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K85401814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25484
BRD-K36529613_P0030_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TP53I3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00598541
Vitamin B12 levels	GWAS Catalog SNP-Phenotype Associations	1.0	0.841354
BRD-K66359319_4151-0165_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OCIM1	CCLE Cell Line Gene Expression Profiles	1.0	1.9542
GSE120612_4_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00727432
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2401
cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042383
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
6104_PBX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.08754
LPCAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81917
lung	GTEx Tissue Gene Expression Profiles	1.0	0.936661
BRD-K62221994_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66356
COL7A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00787786
CHUK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564132
spanning component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.449643
BRD-K20416270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34251
phosphatase	GeneRIF Biological Term Annotations	1.0	null
TAPBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545665
hsa-miR-1270	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K52678950_5377525_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K27915221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.00855
CDK9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0104124
SUM159PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.82029
Perturb_10187_KD_RUNX1|ETO_SRP035930	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.0815
VAMP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0117812
7842_SFPQ_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.134
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.237216
ITPR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00762077
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.81597
PODXL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94225
BRD-K07836769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08376
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
sertaconazole-4475	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
9310_TRMT2B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.05642
BRD-K64890080_BI-2536_HME1_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K53095870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31758
eosinophilia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.206248
EZH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82215
BRD-K68869896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2698
Integument	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73841
SF539	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07929
1352_CCT8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.566344
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A7UZ-01A-12R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17712
IL15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626728
aging	GAD High Level Gene-Disease Associations	1.0	0.293278
BRD-K02822062_CT-200783_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33085
3861_HNRNPC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.649087
HCC1833	CCLE Cell Line Gene Expression Profiles	-1.0	-2.02607
BRD-K37764012_PF-3758309_HA1E_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GPHN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0107203
BRD-A52886023_A8674_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K17649115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18018
KLF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571194
MYB_01_102	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.64636
BRD-A57762296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35633
Photoreceptor distal connecting cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.724
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9979
BRD-K19702946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.25752
NAE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0033875
1268_CCDC174_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.677445
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5683-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.948419
Gemini of coiled bodies	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.023
lateral parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.908405
CD24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582438
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.7574
IL18RAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0100532
etoposide_mus musculus_gpl6887_gse33626	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
layer 5 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76007
SH2D2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614456
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_WSUDLCL2_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A85860691_chaetocin_NCIH1836_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
DICER1_Deficiency_GDS3685_518_mouse_Hepatocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
JSRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00767514
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.342
U937	CCLE Cell Line Gene Expression Profiles	1.0	1.41105
Prostate adenocarcinoma_PRAD_TCGA-CH-5789-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.98862
BRD-A93236127_DIGITOXIN_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A47706533_C1386_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2803-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84924563_6-diazo-5-oxo-l-norleucine_A673_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
APRT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00457335
PPIF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00616498
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.992714
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-9_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30566330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36305
polycythemia vera	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.416521
Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC23A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00699583
GLP1R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621916
BRD-K12986423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02836
CD72	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571853
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.502813
GYG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83873
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0242
SHTN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00613212
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
PRM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00785203
basolateral amygdaloid nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27986
AADAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00553161
6777_PRMT5_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.623835
BRD-A18328003_GDC-0980_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07558
Cytoplasmic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.1506
HNRNPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14907
BRD-A77824596_FLUOCINOLONE ACETONIDE_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SPI1-23127762-K562-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
dexamethasone_homo sapiens_gpl3921_gse28896	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K19731191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40577
BRD-K88198340_2-(6,6-dimethoxy-3-oxocyclohexa-1,4-dienylcarbamoyl)phenyl acetate GNFk-3_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.504318
BRD-K41888813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35162
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6476
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506894
BRD-K12184916_NVP-BEZ235_A375_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
VPS35	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00435915
HSD17B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00685149
2748_ESYT2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.734056
BRD-K15834839_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K58248315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04208
hsa-miR-4261	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Bone marrow_CT2_eosinophil	HuBMAP ASCT+B Annotations	1.0	null
hsa-miR-1299	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05241
CASP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00694758
Perturb_11932_KO_STAG2/RUNX1_SRP199099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
8921_TIMM23B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.651091
BRD-K44640865_VU0365121-1_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A55153871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17463
ML1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43099
layer 3 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02375
intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.116291
BRD-K53936012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14726
Posterior parietal association areas, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46028
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05982
Prostate adenocarcinoma_PRAD_TCGA-J9-A52C-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_704_KD_SETDB1_SRP116955	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
hsa-miR-3667-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
RARRES1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0100978
CD200	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00720628
PUS10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00496543
HLA-DPA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599074
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36857
BRD-K48935217_S1364_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PPM1G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519867
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.694
6492_PNN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535923
BRD-K92317137_-666_WSUDLCL2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
158_ADNP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.35182
TMED7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98354
Postsubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.987
GSE131649_2_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PHTF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00930677
TSPOAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509268
9939_YLPM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513869
2587_ELF4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.719329
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9329
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70186
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3419980-leu201249x4.xls-All_expression_genes_RUNX1ETO-All_differentially_expressed_genes_with_more_than_2_fold_in_at_least_one_day_set_and_correlate_with_RUNX1_ETO_peaks_genes_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K57044355_NCGC00181061-03_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AJUBA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00632195
lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.070642
BRD-K15616905_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8588_SUMO2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.955725
Primary somatosensory area, upper limb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84173
CUX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68696
hsa-miR-576-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-A64774838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42652
BRD-K24337237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37827
BRD-A16313205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48213
blood	GTEx Tissue Gene Expression Profiles	1.0	2.13559
SNPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5406
8873_THAP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.82557
IRF1	ChEA Transcription Factor Targets	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.283295
DICER1_KO_GDS4504_585_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Aortic intima	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.606
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K21296995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40907
CHRM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00457615
BRD-K41895714_AS605240_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
respiratory system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
NR2F6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00370759
LPAR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540817
BRD-A26640795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0803
cellular_component	GO Cellular Component Annotations 2015	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4153_INTS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.870256
CRCGN011_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08025
P4HB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619187
3134_FOLR3_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.742129
BRD-A80960055_3203_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TUR	GDSC Cell Line Gene Expression Profiles	1.0	1.58035
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
intrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.134275
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02749
BRD-U82589721_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCIH727	CCLE Cell Line Gene CNV Profiles	1.0	1.80021
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44377
TRIM24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00828337
TRIB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00649319
BRD-K08547377_Irinotecan hydrochloride trihydrate_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.135
Medial amygdalar nucleus, posterodorsal part, sublayer b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66268
CD151	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00608214
BRD-K85266146_NRB 04155_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
URB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00689598
inner SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25444
APLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.846
ACP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85563
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.931625
BRD-K63584084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51205
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K67036882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20227
UBE2N	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490261
BRD-K24132293_piperlongumine (HPLC)_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44076
DESI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00670988
SNU349	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48258
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ARF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0044088
Medial amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43059
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12518476-10067_2025_7574_MOESM9_ESM.xlsx-Sheet2-RNAseq_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98824517_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K02407574_Parbendazole_MCF7_24.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LTB4R2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00805277
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GLRB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0074648
BRD-A41250203_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OCIAML2	CCLE Cell Line Gene Expression Profiles	1.0	2.13648
RGL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544252
TKKK	DepMap CRISPR Gene Dependency	1.0	2.25388
Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41933
oocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.545342
BRD-K23657553_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K79090631_CGP-60474_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.38552
JcP contribution to LTL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37377
COLO320	DepMap CRISPR Gene Dependency	1.0	5.02337
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39V-11A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intestinal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068522
BRD-K47983010_BX-795_RMUGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Narcolepsy	HuGE Navigator Gene-Phenotype Associations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-A4BW-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.814
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.48507
BRD-K73995655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04294
GAA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00597488
FCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00675079
r10 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13508
BRD-K16885048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0889
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.889411
3710_HEXIM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.787442
SPG7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0101225
fisetin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11419
Chronic myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.203
NR2C2_02_77	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59847
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38488
6748_PRIM2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.560363
GSE76425_0_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SH3BP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00396231
SLC30A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566726
Human - Bone Marrow - L2 - Granulocyte Monocyte Progenitor	HuBMAP Azimuth Cell Type Annotations	1.0	null
ACAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36519
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_24_human_DRSG_higherRes-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1395	CCLE Cell Line Gene CNV Profiles	1.0	1.7285
GSTA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00792233
S100A8 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.782
Perturb_727_OE_QKI5_SRP293637	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0888
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
786_BCAS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.912833
THP1	CCLE Cell Line Gene Expression Profiles	1.0	1.67564
JHH5	CCLE Cell Line Gene CNV Profiles	1.0	2.28667
htm4	GeneRIF Biological Term Annotations	1.0	null
BRD-K84595254_Strophanthidin_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Muscular coat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.734
BRD-K67868012_PI-103_HS578T_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	8.10222
layer 1 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04174
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86411
LMX1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52934
TE10	CCLE Cell Line Gene CNV Profiles	1.0	1.425
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A77216878_manumycin A_NCIH1836_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
valproic acid_mus musculus_gpl6885_gse41020	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NPTX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0124977
8648_TADA2A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.534595
MAP3K20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00508879
SLC5A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0115829
TPMT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0032911
PMC7219112__SF7	PFOCR Pathway Figure Associations 2023	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
BRD-K09537769_NU-7026_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SLC11A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530798
BRD-K28578425_Cilostamide_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16574
r4 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.08122
Allergic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
5928_OGFOD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.671037
CREB_DEPLETION_GDS3487_41_human_K562 myeloid leukemia cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-A45349889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21759
BRD-K39396484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55331
Perturb_13689_KD_TFEB_SRP033784	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CRIM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00544291
spanning component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.449643
BRD-K85275009_methyl 4-hydroxy-2-(trifluoromethyl)thieno[3,4-b]pyridine-7-carboxylate MAY_9_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
gentamycin-sulfate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01211
STXBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00826098
enlarged heart	IMPC Knockout Mouse Phenotypes	1.0	null
layer I of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19927
hsa-miR-3915	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
RNF112	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00734071
HT29	BioGPS Cell Line Gene Expression Profiles	1.0	1.11536
BRD-K12539581_NOCODAZOLE_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sertoli cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.575616
PMC6293073-LSA-2018-00153_TableS3.xlsx-B_KD_Tr_2_genes-155_genes_upregulated_upon_knockdown_of_Tr_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056374
Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15293421_NCGC00241071-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LV-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC16A14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497897
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00087
Medial amygdalar nucleus, posterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00348
BRD-K92317137_-666_NCIH1836_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8435-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A1QS-01A-61R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
supporting cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.198436
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TW-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5162-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1062
CBP-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K43389698_BMS-387032_HS578T_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ITPKA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00535791
BRD-K08753635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21833
superficial stratum of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73396
3-nitropropionic acid-6372	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1791
BRD-K94647035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60796
2700_ERCC8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.604572
HAVCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528203
CAMA1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85152
BRD-K45399554_CAM-9-027-3_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.456
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A19500257_geldanamycin_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K61681480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69963
ZBTB7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00973969
Jejunal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.743
13_AARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.40898
NKRF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00787133
BRD-K52139780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29324
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12041
6130_PCK2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506396
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964219
8218_SNRNP27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.52415
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-1_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
3788_HIST2H2BE_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.541142
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.47411
Lung adenocarcinoma_LUAD_TCGA-91-8496-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1352_CCT8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.546323
RNF168	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00906153
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25119
15755900-Table2	GeneSigDB Published Gene Signatures	1.0	null
TNFAIP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0107138
TYK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00499685
mantle zone of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00887
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.870264
ZFP36L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0116608
PTPRO	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00948922
BRD-K91039552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60943
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49328571_dasatinib_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K69181860_arg-csc-91_RKO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN014_HEPG2_3H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3556
BRD-K52911425_GDC-0941_SKBR3_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A3KAW	DepMap CRISPR Gene Dependency	1.0	2.10265
GNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51573
TMEM43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28682
SEC14L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00420675
BRD-K94833531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52582
BRD-A94413429_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-150-5p	MiRTarBase microRNA Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4710-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9506_UBE2I_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.40464
chronic myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.162026
VRK1_knockout_64_GSE19329	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.796292
ATXN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00666517
PRKAR2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00836912
BRD-K14236372_-666_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
893_BRD8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.683754
GLO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00678868
BRD-K36740062_GSK-1070916_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Primary somatosensory area, lower limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19045
BRD-K18163752_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K56489029_NCGC00238551-02_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE131649_4_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
megakaryoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.482038
BRD-A14424697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68505
Perturb_1701_OE_CLK3_SRP128920	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.3168
GNG11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00651441
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17558
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.941389
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LASV_FML29_24hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.677707
RARA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88083
BRD-K92742972_2-({[2-(4-ethoxyphenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)-N-(2-furylmethyl)acetamide MLS-0052895.0001_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A43155244_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LN443	CCLE Cell Line Gene Expression Profiles	-1.0	-2.02673
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3901
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K29662589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10879
BRD-K62248885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18466
NEMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98339
BRD-K93747373_HG-5-113-01_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLITRK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00430743
1544_CHAF1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.32934
lung cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GYPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0174729
SKIL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00829838
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.34025
spleen	GTEx Tissue Gene Expression Profiles	1.0	1.1904
BRD-K66792149_-666_HT29_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZFP36L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0135378
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520761
AMT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00726531
5263_MRPS34_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.555292
layer IIIu of area 35r	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.949786
OFD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00760663
BRD-A78391468_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
4150_INTS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.29624
BRD-K77343050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09328
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.976376
PMC11976269-41375_2025_2519_MOESM3_ESM.xlsx-ChIP_GATA2_Cluster_A-GeneName_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0469
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964219
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061856
Uterine Carcinosarcoma_UCS_TCGA-N7-A59B-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	123.481
integral component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.391228
Lung cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HDAC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03569
SPI1-23127762-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
EBF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00634061
BRD-A60414806_VINCRISTINE SULFATE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K50140147_HY-10192_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KIF21A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0120491
SOX14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7292
guaifenesin-3897	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DMD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0109866
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10352
BRD-K06765193_5663823_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4775	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-A68930007_OUABAIN_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-1245b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
SLC2A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00510185
JHOS-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K85767870_Adenosine 5'-monophosphate monohydrate_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IL9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565556
Perturb_4875_OE_HAND1_SRP216437	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
IRF2_01_100	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.5213
MYB-21317192-ERMYB-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
5967_ORC3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509129
inherited metabolic disorder	GWASdb SNP-Disease Associations	1.0	0.404737
PMC6694122-41467_2019_11591_MOESM7_ESM.xlsx-f_CEBPA_DEGs-Gene_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
4926_MEAF6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.29027
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
NFE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00622169
BRD-K58347372_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cho cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.442962
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE120612_6_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ROPN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0067733
BRD-K64424704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13944
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.57221
BRD-K74949371_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SASH3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0116153
BRD-K04399953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7858
Flocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20261
BRD-K05151076_ZK 164015_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.557
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.852657
8816_TELO2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.849278
METTL24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00819416
3635_HAUS2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.628054
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.04843
GNG7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587024
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.82078
hsa-miR-514	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
spleen	HPA Tissue Gene Expression Profiles	1.0	1.01438
9833_WDR61_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.748006
NCIH322	CCLE Cell Line Gene CNV Profiles	-1.0	-2.14238
2929_CCNQ_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.624367
BRD-K91600270_NCGC00242557-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K10916986_S1527_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K87158025_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K83125173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72474
7166_RBM25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.566938
BRD-K99252563_QL-XII-47_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SHROOM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0102279
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.995193
SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.204
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2008
BRD-K81821040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43441
MYD88	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00992372
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.627128
BRD-A79768653_sirolimus_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BHLHE40	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00403141
stomach	HPA Tissue Protein Expression Profiles	1.0	1.09761
BRD-K81651477_Parthenolide_SKMEL28_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DOCK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00457645
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
HUNK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00956031
TAL1_02_201	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58855
3980_HSPA9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.48418
Lassa Fever Virus_24hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.59609
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.972575
PDGFRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00658282
lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.07179
Sarcoma_SARC_TCGA-MJ-A68J-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6830-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE196117_6_v_7_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4690-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
TMEM219	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64757
BRD-K54472332_S2001_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
BRD-A34806832_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_9237_KD_ENL_SRP074134	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
p4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.836
496100614_PCx_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.09593
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17558
CEBPB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
1346_CCT2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10418
BRD-K57353465_N-benzyl-2-(indolin-1-yl)quinazolin-4-amine KUC106468N_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
7634_SAE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	2.03879
9420_TUBB_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.510041
HTR5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0101017
CHD7	ENCODE Transcription Factor Targets	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05241
BRD-K82115725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02452
4696_LSM6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.513309
GJD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00638892
BRD-K58347372_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K53308430_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SP3_Deficiency_GDS3058_610_mouse_Embryonic heart  (day 12.5 C57Bl/6)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
cell surface	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.26239
DGKQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57589
cyclin	GeneRIF Biological Term Annotations	1.0	null
RAD21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0152937
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.18089
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.685135
RNF141	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27533
BRD-K02113016_AZD2281 (KU59436)_SNGM_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Mucoepidermoid carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
lung	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CREBBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00864332
FPGT-TNNI3K	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571725
2793_EXOSC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.630666
LN-405	GDSC Cell Line Gene Expression Profiles	-1.0	-1.50458
Prostate adenocarcinoma_PRAD_TCGA-KC-A7F6-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50168500_canertinib_MDAMB231_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K37720887_SB-525334_MCF7_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4852-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CFL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00713548
ENTPD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.013228
BRD-K82145108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58965
layer 4 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10868
PPIP5K2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00762713
6006_OXA1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.604959
Sarcoma_SARC_TCGA-SG-A849-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-A36630025_-666_PL21_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_9851_KD_IBTK_SRP079879	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.7926
611_ATF7IP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.50849
hsa-miR-3142	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
DDX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05515
BRD-K17185909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10991
BRD-K44640865_VU0365121-1_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF764	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26413
PTGER3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00906056
STK32C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00762785
imatinib_homo sapiens_gpl571_gds3518	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K22974051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35571
PMC11906621-41598_2025_93656_MOESM6_ESM.pdf-29-IRF7_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K69023402_THAPSIGARGIN_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC9A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0044644
CCDC74B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69408
EXT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00506408
BRD-K88625236_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12055596-41375_2025_2570_MOESM4_ESM.xlsx-PDX1-Unnamed_13_PDX1	Rummagene Transcription Factor Associations 2026	1.0	null
HSC3	CCLE Cell Line Gene CNV Profiles	-1.0	-2.47503
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5879-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IRF5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0072465
COL4A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00668309
hct-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.66925
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.815257
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-4_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
HSD17B4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539998
ZNF141	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582437
BRD-K13074426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48289
MYBL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4217
hsa-miR-125a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
ANKRD22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00733461
1544_CHAF1A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.01546
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67F-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-U32049204_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TLR10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00853766
BRD-K27221973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54574
TTN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00539476
496100451_TCx_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	6.28145
U2904	DepMap CRISPR Gene Dependency	1.0	2.06987
10445_ZNF557_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.933063
Endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-A53077924_Tianeptine_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZFP90	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0120505
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27743
BRD-K79131256_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IRX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97114
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06755
BRD-K73395020_ARP 101_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CHRNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574976
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
Ppara	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.6151
Leukemia_chronicMyelogenousK-562	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31354
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.570021
BRD-K64409586_KUC104488 KUC104488N_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCIH1650	CCLE Cell Line Gene CNV Profiles	1.0	1.44392
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
BRD-K53903639_480743.cdx_A673_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A91461229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.74365
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DENND1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0053832
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59274
BRD-K00615600_AG14361_HT29_24.0_h_25.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YAPC	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36659
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05382
BRD-K41996876_AG 9_SW948_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GATA2	ENCODE Transcription Factor Targets	1.0	null
1348_CCT4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.725523
ovary	HPA Tissue Gene Expression Profiles	-1.0	-0.888279
SZT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0092989
6516_POLD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.721142
CAAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32176
BRD-K58347372_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
secretory granule membrane	GO Cellular Component Annotations 2025	1.0	null
BRD-K72414522_AZD-5438_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sertoli cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.219101
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
intermediate stratum of TG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02165
4150_INTS5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.725143
CEBPB_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
spleen_3d	HPA Tissue Sample Gene Expression Profiles	1.0	0.828603
BRD-K48654774_-666_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EP300	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0052385
BRD-A05883068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20638
BRD-K34092011_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
MIA PACA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.995193
layer 3 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19969
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.19652
BRD-A57382968_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RARA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00965204
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6919
interleukin-3 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.664
FJX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00448204
Lung squamous cell carcinoma_LUSC_TCGA-58-8386-11A-01R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventral posteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21157
GJB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537222
r2 part of anteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28756
CMK115	CCLE Cell Line Gene Expression Profiles	1.0	2.65486
BRD-K46121327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12229
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4271
BRD-A84327315_71820_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K66538826_amuvatinib_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
7843_SFSWAP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.704504
PDPN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543678
ZNF384	ENCODE Transcription Factor Targets	1.0	null
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-RELA_DN_V1_UP-Ensemble_gene_ID_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11354
EP300_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A19500257_geldanamycin_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LHX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1383
PMC7921413-41467_2021_21650_MOESM5_ESM.xlsx-002_DE-CD34_Blasts_AP1_low_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
PCGF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00640497
BRD-K27049948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46212
2251_DMAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.658521
4158_IP6K1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.76059
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A2OS-01A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.60445
BRD-K53523901_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.865284
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-6_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3702
BRD-K05635176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19578
9751_VPS35_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.550523
SF539	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.918452
INSRR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.006174
LRRC40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41701
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11873
BRD-K08206212_S1252_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K38557728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00801
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.330966
1579_CHMP1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516966
GSE234155_7_v_1_nfix_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K59182232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39514
6676_PPP1R8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.612312
BRD-A54927599_KF 38789_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ITGA11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00424035
BRD-K09460582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09669
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17588104_(-)-JQ1_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Primary somatosensory area, mouth	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48269
Lung adenocarcinoma_LUAD_TCGA-35-4123-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54503842_JAS07_010_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55643
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.592872
BRD-K40175214_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K72414522_AZD-5438_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4682	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K90733503_Cephalexin monohydrate_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
thymoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.658678
BRD-A77577770_AC-1121_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CIB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00529142
Lung squamous cell carcinoma_LUSC_TCGA-34-7107-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.888279
Primary somatosensory area, lower limb, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.51823
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
Cortical amygdalar area, anterior part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63424
CDK2	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-A61599461_NCGC00229600-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DGKB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00618954
4004_IARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564279
thymus cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.385936
proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.17687
PADI4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639499
BRD-K16364953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36949
GSS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00859152
PAX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7343
Childhood Leukemia	DisGeNET Gene-Disease Associations	1.0	null
BRD-K37865504_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K78596368_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4701-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06436
BRD-A27844016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3072
EPCAM_OE_GDS4887_343_human_IL-28B	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE185519_3_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5869_NUDT21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.06658
Acute Myeloid Leukemia_LAML_TCGA-AB-2999-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLRB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00899554
BUD31	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00683327
PLCXD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00489062
PSMB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00581084
SMIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67912
BRD-A94756469_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.194865
BRD-A95513702_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
569_ASB8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.838874
TBCCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72068
protein binding	GO Molecular Function Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A76L-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K93316985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.90568
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4334
BRD-K99252563_QL-XII-47_HME1_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OC314	DepMap CRISPR Gene Dependency	1.0	3.41189
VENTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32188
BRD-K61711624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10545
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.19
TET2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54241
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
PLCG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00657535
3308_GBF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.536482
BRD-K31230200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6534
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9058
EGF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0131675
BRD-K49328571_dasatinib_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A76528577_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K03816923_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
superficial stratum of r2Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28756
KDM4E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00527414
1206_CASP8AP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.04675
GLYATL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0104228