association	dataset	threshold value	standardized value
Combined oxidative phosphorylation deficiency 7	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.919181
BRD-K13169950_NSC 3852_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OAS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00798235
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
Methanophenazine reducing hydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.279
BRD-K36740062_GSK-1070916_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LU65_LUNG	CCLE Cell Line Proteomics	1.0	2.18106
PMC9314667-Table_1.xlsx-Regulons-MITF_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
RSV_48Hour_22398282_GSE32138	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.85535
BRD-K17349619_HLI 373_COV644_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OC-10-FB51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.792675
posteroventral (inferior) parietal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.897865
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XE-01A-12R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DE-97-IV02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250724
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.22308
SKIL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00666445
PMC12978397-wjon-17-02-247-s002.xlsx-S2-Suppl_2_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25690923_-666_COV644_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A79768653_sirolimus_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.336619
IRAK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00652754
actin polymerization or depolymerization	GO Biological Process Annotations 2015	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.63233
MYC-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TNFAIP6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00656964
BRD-K67578145_GDC-0879_A375_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12913833-12672_2026_4481_MOESM3_ESM.xlsx-Table_S1-Table_S1_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
LN18	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37791
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
Mitochondrial electron transfer flavoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.515
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291064
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0307
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.7476
BRD-K63606607_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WHWD-0426-SM-3LK83	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27105
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.29103
GTEX-XMK1-1826-SM-4B66F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952146
BRD-K13169950_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GAB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543857
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.6489
INCB 3284	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-1226-SM-2XCFP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10748
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ3S-0526-SM-4BOQA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89565
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34856
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282717
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892336
GSE240027,GSE240030_5_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LCLC-103H	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02503
AM095	DeepCoverMOA Drug Mechanisms of Action	1.0	0.37
Thyroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.16909
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K88510285_B675700.cdx_U937_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.25005
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68535
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	1.0	0.8753
Stele	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.207
BRD-K19499941_STOCK1S-53863_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K38487270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02452
BRD-K24652731_Ivermectin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EPOP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561223
SKMEL1	CCLE Cell Line Gene Expression Profiles	1.0	1.79046
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.8497
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-gene_short_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4B-Up_Nanog_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.391615
BRD-K53717076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73043
Radicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.631
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.55898
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.94461
Lung adenocarcinoma_LUAD_TCGA-86-8673-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
B4GALT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01476
ZDHHC17	Pathway Commons Protein-Protein Interactions	1.0	null
KMRC1	DepMap CRISPR Gene Dependency	1.0	2.60197
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	119.588
GTEX-XUW1-0926-SM-4BONX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00871
SERPINC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00602589
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.258985
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.985529
BRD-K53414658_tivozanib_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PCIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42622
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.853105
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K54533560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46824
disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043323
HTR6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00530045
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1775
t69-brown-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	3.363
BRD-K23578173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17367
Commensal bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
PMC4540202-cddis2014370x2.xls-Sheet1-Table_S2_MEIS2-responsive_genes_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.245233
BRD-K25013674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05018
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Accessory olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0317
3866_HNRNPH1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521936
GTEX-X3Y1-0226-SM-3P5Z5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86593
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.18519
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCND1	ChEA Transcription Factor Targets	1.0	null
BRD-K50841342_PAC 1_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary auditory cortex (core)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.830636
ZFP281-18757296-E14-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MAZ_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular	GeneRIF Biological Term Annotations	1.0	null
GSE205316,GSE205317_0_v_1_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08271
Inner mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.495
BRD-K16136897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57034
GTEX-S4P3-0626-SM-4AD59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7161
BRD-A81552806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12099
cerebellar vermis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.71336
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56071
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Z-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78867378_mw-A1-12_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IRF6_KO_GDS2359_126_mouse_skin E17.5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
9215_TPR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.969532
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12938
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
biological regulation	GO Biological Process Annotations 2015	1.0	null
GSE169152_5_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21099
BRD-K77733130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86475
BX 471	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
CTCF_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEL4-0926-SM-3GAD1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93989
MC116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34687
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
GSE152055_0_v_1_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A495-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06271
GSE139911_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BICR18	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40107
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-55-XA97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277808
GTEX-RU72-0011-R8A-SM-2TF61	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978132
CREBRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11115
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30682
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NUDUL1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.2707
GTEX-XQ8I-0226-SM-4BOPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84366
Interanterodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54056
NTRK3_drugactivation_67_GSE20358	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.57625
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vitiligo	DisGeNET Gene-Disease Associations	1.0	null
GTEX-QESD-1426-SM-2S1R9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27464
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.08549
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE101546_3_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.16607
mantle zone of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61088
GSK3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582722
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.4322
GSE203655_0_v_1_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PHA granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.182
NEIL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592423
hsa-miR-4790-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE168233_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30142
cisplatin_homo sapiens_gpl570_gds3910	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COL1A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0084657
POLE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00344838
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2A_MEF2A	Rummagene Transcription Factor Associations 2026	1.0	null
Ventromedial hypothalamic nucleus, dorsomedial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37852
PMC10679653-mmc4.xlsx-ISL1_KO_Markers_T_L-Unnamed_0_ISL1	Rummagene Transcription Factor Associations 2026	1.0	null
ALDH18A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0041707
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.275
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30559
GTEX-OHPN-0011-R5A-SM-2I5FF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890221
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.64979
Eczema_Integument_GSE6012	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.5691
TEAD4	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0065257
Urinary tract infection	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
BRD-K01793276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40215
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CV-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.917
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29543
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23278
6275_PHB2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.641188
COLO775	CCLE Cell Line Gene Expression Profiles	-1.0	-2.01219
8666_TAF5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.537535
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059385
ventral part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48397
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K09951645_dabrafenib_A375_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09643
GSE100102_2_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K37764012_PF-3758309_A375_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K72452130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20254
BRD-K37687095_AZD-8330_HS578T_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K38557728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86423
Fbxl10_OE_GSE34691_579_mouse_fibroblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
FOXO1::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.0882
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FDR_0_1_RELB_RNAi-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOP-92	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.20318
NCIH196	CCLE Cell Line Gene CNV Profiles	1.0	2.05689
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.423567
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K02822062_CT-200783_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
15361855-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
16289389-Table2a	GeneSigDB Published Gene Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.621024
SIRPD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00740654
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K59069382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46834
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain	GeneRIF Biological Term Annotations	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FA-36-VA24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238555
GSE203072_2_v_3_rpl3l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Thyroid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.26094
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F9-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34499
EGR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81209159_HERNIARIN_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.413
intermediate stratum of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11393
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01723566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83107
BRD-K49865102_PD-0325901_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CMK115	DepMap CRISPR Gene Dependency	1.0	2.00056
BRD-K61553312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04612
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.802966
BRD-K41895714_AS-605240_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A654-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Telotristat	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
GSE122215,GSE122217_5_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20991
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27425
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8613_KO_Ctcf_SRP078142	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.51557
LCLC97TM1	DepMap CRISPR Gene Dependency	1.0	7.09363
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15474
TOV21G	CCLE Cell Line Gene Expression Profiles	1.0	1.43053
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.164359
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01962
BRD-A59174698_RITODRINE HYDROCHLORIDE_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.028925
BRD-K17705806_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K56343971_vemurafenib_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSTA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532816
BRD-K20735575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19185
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.966134
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Weight Gain	CTD Gene-Disease Associations	1.0	1.08231
FB-06-IU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291451
GSE210383_0_v_1_trim71_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K36me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93034159_2-chloro-2-deoxyadenosine_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2987-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16126
GSE143743_0_v_2_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4842-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08901
hsa-miR-4677-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
6549_POLR2H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.796576
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1394
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81233
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5568-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VSTM2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00635281
MAC2A	DepMap CRISPR Gene Dependency	1.0	2.27809
GSE196117_1_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE173911,GSE173917_0_v_1_morc3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A492-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15442
Fbxl10_OE_GDS4788_580_mouse_fibroblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
plastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.629892
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	1.0	2.82317
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.901
Prdm15	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.0286
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
heart muscle	HPA Tissue Gene Expression Profiles	1.0	2.23654
ventral premammillary nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.01681
together	GeneRIF Biological Term Annotations	1.0	null
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
7062_RAD21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50317
TMEM98	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00714325
perifornical nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4838
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPID	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00577543
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.468
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4691-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
actin filament polymerization	GO Biological Process Annotations 2023	1.0	null
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
outer CP in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.869685
GTEX-XYKS-1026-SM-4BRVH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82857
GSE148066,GSE157787_3_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.8783
GTEX-T5JW-0226-SM-4DM7I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27892
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.307256
GA-28-SS67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.461252
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC6642071__F1	PFOCR Pathway Figure Associations 2024	1.0	null
NUGGC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00745521
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.91373
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.50079
Plant bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.747
Congenital myopathy 1B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
GSE100732,GSE100733_0_v_1_lrpprc_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.70176
GSE216147_0_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ULK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00645615
BRD-K11113009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30078
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3052
2292_DNAJC19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.545803
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.6545
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
APLNR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00624172
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20432
MN-60	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52628
hsa-miR-526b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE240030,GSE252532_0_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FA-80-DR66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.255806
KURAMOCHI	CCLE Cell Line Gene CNV Profiles	1.0	1.53422
GTEX-WFG7-1026-SM-4LMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912449
NXPE4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00829682
TE-26-XS06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205365
FSCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07031
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.668
GAS7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00527953
subthalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23996
BMPR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00508698
PANC-08-13	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.13954
primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.87639
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62648
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.18132
SSTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00576
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.645347
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.54839
MUC20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590991
SHSY5Y	DepMap CRISPR Gene Dependency	1.0	2.4078
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
NCIH146	CCLE Cell Line Gene CNV Profiles	1.0	1.55469
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34654
GSE213588_9_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_KO_GSE39009_49_mouse_skeletal muscle (6 mo)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
msr	GeneRIF Biological Term Annotations	1.0	null
GSE132694,GSE132717_0_v_2_meis1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.6127
6867_PSMD13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.563276
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A25234499_aminoglutethimide_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928451
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05383
GSE178714_5_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KURAMOCHI	COSMIC Cell Line Gene CNV Profiles	1.0	2.59653
BRD-K88538240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09579
mRNA_NRIP1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.91291
MEK162	DeepCoverMOA Drug Mechanisms of Action	1.0	1.1
NOTCH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00890749
BRD-K08558441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17044
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.49249
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895863
GSE196671_5_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4981-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XLM4-2026-SM-4AT4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50083
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623386
BRD-K73394628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.57212
Hepatic cecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
POLR2AphosphoS5_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53547009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36491
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84572
posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.961563
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.089105
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908384
GSE153443_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_TMP195_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139042
regulation of transcription, dna-templated	GO Biological Process Annotations 2015	1.0	null
BRD-K04546108_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TA-20-FO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259035
skin_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.17076
GATA3	ENCODE Transcription Factor Targets	1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895141
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.113484
BRD-K16406336_METHYLENE BLUE_SKMEL28_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE129153_0_v_1_forskolin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49226
methionine-importing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.092
YY1_Deficiency_GDS4856_318_mouse_Soleus skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Precommissural nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17284
BRD-K86472598_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.9024
CRCGN008_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18928
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SARS-CoV MA15_Day2_None_GSE49262	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.67639
IRF1	ENCODE Transcription Factor Targets	1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVN-1626-SM-48TZC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846604
EP300	ENCODE Transcription Factor Targets	1.0	null
GTEX-XAJ8-1426-SM-47JYM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22303
VPS72	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510497
EPHX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00703804
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.503705
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.821
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16078
CD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00397519
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-2.06081
NR0B1-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MYOM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060234
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56127
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW-403 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
GTEX-XPVG-1726-SM-4B65W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24323
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059854
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Field CA2, stratum radiatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12483
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826502
CTCF	ENCODE Transcription Factor Targets	1.0	null
BRD-K63008302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64293
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.129
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
pa96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.0
buflomedil-1338	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cystitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.6214
lung	GeneRIF Biological Term Annotations	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.24213
Fatty Liver	CTD Gene-Disease Associations	1.0	1.46172
BRD-K73155123_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IL18BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00503074
LRCH4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491241
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210388_2_v_0_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
KCNH7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582125
TFPI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0053416
BRD-K29458283_chlorambucil_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05217
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.893927
OC-53-QX76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282454
MAST2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522972
TUBA4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535917
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K88198340_2-(6,6-dimethoxy-3-oxocyclohexa-1,4-dienylcarbamoyl)phenyl acetate GNFk-3_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.721654
BRD-K98704738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06515
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78659596_MLN2238_TYKNU_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
5190_MRGBP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.716806
H3K36me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50849
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.953836
GTEX-PWN1-0126-SM-2I3FK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09745
irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.030387
BRD-K08451418_5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K06320746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61765
GM2313	BioGPS Cell Line Gene Expression Profiles	1.0	1.2414
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.715827
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910374
BRD-K73789395_ZM 336372_U937_6.0_h_102.71_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K12621773_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
5441_NACA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.632518
roxarsone-2950	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MEST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00421238
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2C_MEF2C	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79090631_CGP-60474_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.92837
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.45014
BRD-K01853144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59026
GSE213048_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A78360835_cercosporin_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LYL1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
P2RY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41393
hsa-miR-4264	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
CTV1DM	DepMap CRISPR Gene Dependency	1.0	11.0129
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PAX3	ChEA Transcription Factor Targets	1.0	null
CXCR6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005022
Peptide methionine sulfoxide reductase	InterPro Predicted Protein Domain Annotations	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H1_Cell_Line	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.99366
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.403626
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4733
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.16017
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.963
response to stimulus	GO Biological Process Annotations 2015	1.0	null
CIRBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.004169
LIVF001-022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34072
4951_MED28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.580055
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8601
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21269
PLXNA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543268
KLF4-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K56ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K35049668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69373
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10R-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K91699951_Benzonatate_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32108
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.44715
SEC14L4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0074248
CTCFL_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.56214
dorsofrontal pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22422
Arid5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.0282
WM-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08236
GATA1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33164
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NR4A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00686626
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.913988
Fungal infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anthraquinone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25391
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298467
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EGR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0062851
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.90555
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Plastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.543
PMC3805607__F3	PFOCR Pathway Figure Associations 2023	1.0	null
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268099
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4847-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1482	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.89472
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
medial tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.18285
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87385385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24961
adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.132681
BRD-K13514097_S1120_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IB-33-TE51_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245557
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.61422
GA-28-SS67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.78443
BRD-K32827536_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IKZF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00340972
BRD-K88135858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37414
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.53013
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.7576
Prostate adenocarcinoma_PRAD_TCGA-G9-6498-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7822-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205316,GSE205317_0_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.15868
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.490905
GSE226249_2_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Proventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
496100618_PCx_probable Alzheimer's disease_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.4062
HCC2279	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3835
BRD-K41859756_-666_HCT116_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HS 675.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24908
ESC_V6.5_UP_LATE.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Nuclear senile cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.00385
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-WH-A86K-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5F1-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
BRD-A79768653_sirolimus_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SPI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0090491
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.686
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.597
BRD-K38118311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08491
Presubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18501
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82971429_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BHY	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62876
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.964793
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960559
BRD-A28105619_curcubitacin I_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KLM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.837089
BRD-K24170552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27195
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34864
4161_IPO13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.525449
EWSR1	ChEA Transcription Factor Targets	1.0	null
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17842
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4486168-pone.0131961.s006.xlsx-Sheet1-ARID3B_Down_Regulated_Genes_ARID3B	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE189653,GSE203344_5_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148066,GSE157787_2_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU1F1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00665757
chr10_23072185_C_T_b38	GTEx eQTL 2025	1.0	2.13432
GSE179031_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.61513
Lhx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.3767
GSE189772,GSE189773_3_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0526-SM-4BOON	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74568
Left atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.1
ZFX-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K39120595_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61132
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K34005205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00428
YY1	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2622_EMG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.569015
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68541
Bacteroid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.454
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.623407
BRD-K21982562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40805
Flower bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.76
GTEX-PLZ6-1426-SM-2S1OQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08857
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966119
NF-21-HQ00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.3015
Blood Coagulation Disorders	CTD Gene-Disease Associations	1.0	1.04276
NFIC	ENCODE Transcription Factor Targets	1.0	null
GSE218060_5_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18857
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU7-0926-SM-4BRX1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72938
GSE230354_0_v_1_rheb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ciliary body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38144
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5175-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Root hair tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.255
BRD-K26997899_D-64131_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
liver	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.236332
hsa-miR-4520a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE205687_1_v_0_mta1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24132293_piperlongumine (HPLC)_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0626-SM-4BOOO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16355
Perturb_16531_KO_Cdk8/Cdk19_SRP351257	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.11228
7439_RPL15_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02702
PFKFB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00578117
DF-03-OP38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.343469
GTEX-T6MN-0011-R4A-SM-32QPG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834358
STKLD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00869644
heart	GeneRIF Biological Term Annotations	1.0	null
BRD-K23589316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01147
BRD-K09819684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.012
893_BRD8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.558349
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74305673_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K25737009_-666_HCC15_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1031
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846839
GSE118794_2_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEp-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.835
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
EDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40896
NRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7259
BCL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00441581
PC-62-AQ92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.703664
Mitochondrial prohibitin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.964
Bed nuclei of the stria terminalis, posterior division, strial extension	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38809
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858149
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46968
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42902
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.3823
Intralaminar nuclei of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01019
Cotyledon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.133
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K67352070_TC 2559 difumarate_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	171.535
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13J-11A-13R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K94409042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4545
Vascular endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.117
STAT1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13937_KD_PHOX2B_SRP345639	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4494-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.89619
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.1868
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PLOD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00281862
macromolecular complex assembly	GO Biological Process Annotations 2015	1.0	null
GTEX-XV7Q-0226-SM-4BRVL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23646
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH28	DepMap CRISPR Gene Dependency	1.0	4.98008
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0748
GSE119694_1_v_0_lifr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112860_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1643
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Planktonic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.046
Lung squamous cell carcinoma_LUSC_TCGA-37-A5EL-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brain ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.170846
ZFP281-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K25982056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31383
mbn-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.925
BRD-A39996500_radicicol_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A47816767_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05549
NRF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PC-62-AQ92_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450299
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE203158_0_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K53561341_KIN001-220_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UPJH-0326-SM-3GADU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.971544
MAPK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00471804
BRD-K24468827_NCGC00181918-02_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intermediate stratum of PHyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25663
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5000-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53461563_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51313569_palbociclib_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K68174511_torin-2_MCF7_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE231720,GSE231724_2_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
DU-4475	GDSC Cell Line Gene Expression Profiles	1.0	2.44583
reductase	GeneRIF Biological Term Annotations	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81I-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Microvascular endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.127
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.2244
GTEX-R55G-0926-SM-48FDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10582
BRD-A43155244_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease Progression	HuGE Navigator Gene-Phenotype Associations	1.0	null
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18588
non-syndromic X-linked intellectual disability 91	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.39
BRD-K85606544_neratinib_HS578T_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.208
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.45429
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76703230_YM-155_HA1E_24.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
6050_PAM16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.698303
DPP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552839
BRD-K18190982_COT-10b_HCC15_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.63081
SLC26A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00427362
core of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1562
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06531
CDC42SE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00503632
Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of biosynthetic process	GO Biological Process Annotations 2015	1.0	null
protein repair	GO Biological Process Annotations 2025	1.0	null
hsa-miR-139-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A58280226_Y27632_VCAP_6.0_h_4.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052773
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.827211
BRD-K65203256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81789
hydrogen	GeneRIF Biological Term Annotations	1.0	null
HCC1500	CCLE Cell Line Gene CNV Profiles	1.0	1.42139
Supramammillary nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03426
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.68982
protein metabolic process	GO Biological Process Annotations 2025	1.0	null
medial habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.45359
GSE218060_2_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45941986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12827
BRD-K09711841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05379
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.848463
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
be107	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.467
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LU99	CCLE Cell Line Gene CNV Profiles	1.0	1.37275
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.645489
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.419835
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K54256913_MK-1775_HEPG2_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K24143478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00832
GTEX-U8XE-0326-SM-3DB8P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84896
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09613
CTCFL_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NE-34-OZ69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332385
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97365
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.37441
BRD-K01250897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77774
Cell septum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.997
TIM23 mitochondrial import inner membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.826
cytosol	GeneRIF Biological Term Annotations	1.0	null
BRD-K78211834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16599
BRD-K01095342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00562
oxidoreductase activity	GO Molecular Function Annotations 2015	1.0	null
heart_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.55001
Root cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.263
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ONX 0914	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.37
BRD-K53417444_OTSSP167_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HS-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05535086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05211
C19orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04983
Spongiome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.657
Prostate adenocarcinoma_PRAD_TCGA-G9-6379-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLR25	CCLE Cell Line Gene CNV Profiles	1.0	1.70796
BRD-K29935988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28102
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.479457
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.860626
higher	GeneRIF Biological Term Annotations	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.555274
Obesity_Muscle - Striated (Skeletal) (MMHCC)_GSE474	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.47225
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.87047
GATA5_KO_GSE47425_50_mouse_lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K26647686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62689
BRD-A75409952_wortmannin_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K80431395_TRICIRIBINE_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bronchus	HPA Tissue Protein Expression Profiles	-1.0	-1.06452
GSE180200,GSE180201_15_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06002
GSE169205_0_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26871
BRD-A19633847_PERHEXILINE MALEATE_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K12359218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39501
GTEX-QCQG-1726-SM-3GIJ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30465
layer 6b of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01273
BRD-K34533029_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAF-26560356-CHIP-SEQ-TH1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE210101,GSE210114_6_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
kidney disease	GWASdb SNP-Disease Associations	1.0	0.912987
DDX21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00451933
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XV7Q-2226-SM-4BRVY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01256
schistosomiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.528835
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
protein polymerization	GO Biological Process Annotations 2023	1.0	null
CRCGN012_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18945
BRD-K49328571_dasatinib_A375_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PYGO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11812
CA-88-FC74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316057
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A75769826_SDM25N hydrochloride_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K01614657_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE81803,GSE81912_3_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A60245366_AS-601245_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC6811834-sby183_suppl_supplementary_data_set_1.xls-ZNF804A_DEX_FDR_0_01-Gene_Symbol_ZNF804A	Rummagene Transcription Factor Associations 2026	1.0	null
MM253	DepMap CRISPR Gene Dependency	1.0	3.38831
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.40091
BRD-A80960055_3203_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
IFNA17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00818728
GTEX-WFG7-1226-SM-4LMK2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988568
NFYB-21822215-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.528549
GTEX-X3Y1-0426-SM-3P5Z4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04923
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.707131
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.71377
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17328
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96608
496100557_TCx_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01111
BRD-K46737746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05473
BRD-A36275421_MW-ras12_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
G402_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	2.34311
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17819
GSE121824,GSE121826_0_v_2_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GJA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00463343
BRD-K96997646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48028
Phycobilisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.767
NECTIN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00522201
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3-21878914-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GPX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00759852
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28745
REST	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K16730910_regorafenib_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00258
BRD-K57357721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34479
IHF-DNA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.97
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49712247_NCGC00167098-01_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.07743
EWS-ERG-20517297-CADO-ES1-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
heart	GTEx Tissue Gene Expression Profiles	1.0	2.17911
toxin-antitoxin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.278
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-562	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.999927
BRD-K56987347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01819
ZNF143	ENCODE Transcription Factor Targets	1.0	null
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73041
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3137_KO_Celf1_SRP082172	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.82302
TAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00741927
BRD-K30677119_PP-30_RMGI_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
entire	GeneRIF Biological Term Annotations	1.0	null
SUZ12-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Germ tube	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.79
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.89479
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03252
BRD-K92571446_WZ-3105_A549_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
7607_RUVBL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.671437
claustrum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.8422
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.264
GSE240896,GSE240899_5_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R55G-0526-SM-2TC5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25827
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C6-06A-12R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4951_MED28_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.7551
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24303
NR3C1	JASPAR Predicted Transcription Factor Targets	1.0	null
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053768
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
SNU840	DepMap CRISPR Gene Dependency	1.0	4.62328
GTEX-XQ3S-1026-SM-4BOPJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11941
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.57226
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46677
BRD-K56593336_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A24436948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53704
central gray of the pons, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00954
1200_KNL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.707308
Cervical epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.191
BRD-K81418486_vorinostat_RKO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.05897
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Aripiprazole	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
GTEX-RM2N-0626-SM-48FD6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888576
GSE168797_2_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.338104
Cytosolic region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.829
BRD-K04531886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34515
SA-32-CC58_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204021
FES	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00500509
MEG-01 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.827615
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
ZNF581	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20085
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284805
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.56961
Prostate adenocarcinoma_PRAD_TCGA-KK-A7B0-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55G-0326-SM-48FDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42577
PMC11794132-41375_2024_2473_MOESM9_ESM.pdf-10-NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.866943
protein complex subunit organization	GO Biological Process Annotations 2015	1.0	null
BRD-K12867552_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GA-04-JM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295305
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.820042
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5546-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WYVS-2126-SM-3NMA3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911841
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TFAP2C	ENCODE Transcription Factor Targets	1.0	null
Methyl accepting chemotaxis protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.106
BRD-K28360340_TW 37_SKMEL28_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.27969
7463_RPL35_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.539807
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IGF1_OE_GDS3484_542_human_MCF-7	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15285
BRD-A47513740_calyculin A_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.946407
GIMEN	DepMap CRISPR Gene Dependency	1.0	2.13211
BRD-K61310138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89556
MYC	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-6202-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291015
NANOG-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
core of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.00631
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ADAM10	Pathway Commons Protein-Protein Interactions	1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.928529
GSE192513,GSE192515_1_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
r10 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39869
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PU1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
wi-38 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.599273
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49865102_PD-0325901_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K06399794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40144
GTEX-U8XE-0526-SM-3DB8R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903204
Lateral habenula	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49887
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RF-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.14438
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	3.82452
4941_MED19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.788979
catalase	GeneRIF Biological Term Annotations	1.0	null
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99633092_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CES1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00629363
ATP5F1D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575227
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE238116_1_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90911
single-stranded DNA-binding protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.301
IL5RA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509176
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202671
BRD-K78126613_MENADIONE_SW480_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	231.126
BRD-K21680192_mitoxantrone_BT20_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AIRE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00511878
PMC9810535-41590_2022_1370_MOESM3_ESM.xlsx-Table_S7-MECOM_down_genes_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
REST_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213632_1_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMC3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BB-86-UL91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218677
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE162739_8_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H1-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-DX-A3UD-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5022-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50140147_HY-10192_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K72253829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74857
ZNF184	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.5784
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Atrophy	CTD Gene-Disease Associations	1.0	1.07093
ERG-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
EB-67-WB79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223534
GSE82110,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84479
NBsusSR	GDSC Cell Line Gene Expression Profiles	-1.0	-1.55811
4931_MED11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.745065
parvicellular interstitial nucleus of the posterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1376
4273_KARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.719918
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KCNQ3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482695
4940_MED18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.821745
BRD-K93866368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40758
BRD-K62288678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35211
GP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00438329
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.17966
glutaredoxin	GeneRIF Biological Term Annotations	1.0	null
8157_SMC3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.95973
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19469
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824093
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861067
BRD-K64890080_BI 2536_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K62237490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43976
BRD-K49865102_PD-0325901_MCF7_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
regulation of cellular macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K06318195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04031
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2568
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05706
GSE186440,GSE186443_3_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S341-1726-SM-3K2AK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35879
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Mesocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.065
Cell pole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.376
BRD-K33787033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0319
PBX3	ENCODE Transcription Factor Targets	1.0	null
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MXRA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00738715
BRD-K49577446_flunisolide_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.884133
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.06089
GTEX-OIZG-0726-SM-33HBL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828807
ROR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593906
mRNA_SFPI1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
PMC12035842-ijmsv22p2139s1.pdf-5-ATF4_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53792571_Inhibitor BEC hydrochloride_HCT116_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JcPL part of the periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05482
GTEX-WY7C-1126-SM-3NB3A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00802
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16421
Superoxide dismutase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.145
Sarcoma_SARC_TCGA-K1-A3PO-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
INPP4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00680058
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
repair	GeneRIF Biological Term Annotations	1.0	null
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.8724
BRD-A19037878_trichostatin A_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.979955
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
IL1R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055015
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14225
HM7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.63119
MAP2K7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491649
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE92364_1_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K63487554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03217
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27777
Dmbx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9603
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37768
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.874995
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.872268
KARPAS-299	GDSC Cell Line Gene Expression Profiles	1.0	2.19226
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.536504
2764_ETV4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.61441
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.623778
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.839223
PMC7488531-13287_2020_1914_MOESM10_ESM.xlsx-HNF4A_regulated_DEGs_750-Unnamed_1_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.948402
BRD-K40711313_VU0424182-2_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K49103797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16704
GSE240027,GSE240030_1_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3770-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
interanterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59352
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.398
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68348
Brain Lower Grade Glioma_LGG_TCGA-HT-7483-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Eye	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Alkyl hydroperoxide reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.472
GATA1_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
midbrain reticular formation	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.865341
Sarcoma_SARC_TCGA-DX-A8BK-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
methionine	GeneRIF Biological Term Annotations	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.79895
Perturb_7808_KD_ACIN1_SRP075202	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CT-26 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
intermediate stratum of PcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22422
GSE223008_5_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arbuscule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.967
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.942432
hsa-miR-125a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA3	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K93123848_RAF 265_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.36648
GSE123105,GSE124556_0_v_2_pcf11_human	RummaGEO Gene Perturbation Signatures	1.0	null
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.39759
BRD-A39996500_radicicol_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC3303130-NIHMS40463-supplement-4.xls-KamKwaMuk_AA_differences-human_geneID_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0449
KF-18-RY71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254943
Amino acid transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.124
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.907969
PPIF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00737974
SOX2-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Dent disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.431
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.847072
STAT3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HRH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00666929
intermediate stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54327
NCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559107
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cefazolin-2564	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.63032
Field CA2, stratum oriens	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25369
Obstructive sleep apnea_Hepatic Tissue_GSE1873	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.54078
BRD-K07396820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92175
GTEX-O5YT-1326-SM-3MJGR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953575
LPAR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585694
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00418
BRD-A19500257_geldanamycin_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	78.1382
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FR 180204	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
MCF12A	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.691195
Photosynthetic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.086
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE186440,GSE186443_4_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
oxidoreductase activity, acting on a sulfur group of donors	GO Molecular Function Annotations 2015	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.795
capillary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23459
GSE214823,GSE214824_6_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
tissues	GeneRIF Biological Term Annotations	1.0	null
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Actin cortical patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.79
CTSB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00356989
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.5224
lateral periretromammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50755
BRD-K59709341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03777
BRD-A39996500_radicicol_HEPG2_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K11853856_PJ 34 hydrochloride_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RNOR-0826-SM-2TF5C	GTEx Tissue Sample Gene Expression Profiles	1.0	2.63304
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22064
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20993
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34
TDO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00652852
BRD-K48782834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37032
Nectar	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.76
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25371
BRD-K19166598_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-0226-SM-47JY8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50921
BRD-K96250732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74664
BRD-K88494268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05588
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30234
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K98272474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21064
NR0B1	ChEA Transcription Factor Targets	1.0	null
BRD-K12343256_trametinib_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.754
Kidney Chromophobe_KICH_TCGA-KN-8433-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47962810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25283
Seed coat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.025
GTEX-TSE9-0326-SM-3DB82	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914306
GSE216394_2_v_0_pfkp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRAPPC13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628275
NR0B1-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K09951645_dabrafenib_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258399
agranular insular cortex (area Iag)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.838889
7453_RPL26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.555913
Oxidoreductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.139
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.886232
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02816
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88085
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UPIC-0726-SM-3GADW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65238
BRD-K84595254_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.3362
FB-32-PY27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.48906
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.848555
BRD-K72156149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23745
BRD-A41451487_PK-11195_A375_24.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCM2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74786
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21161
BRD-K67578145_GDC-0879_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K14193598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23393
eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.222136
PMC4595011-pgen.1005555.s002.xlsx-MITF_UP_in_30kb-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.29287
superficial stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2439
preservation	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.2048
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47801
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48959
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830963
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE165579_0_v_1_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01781
SP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.57996
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40356
endoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.318205
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06201
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991959
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K95352812_NCGC00188530-01_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.529
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
betulinic acid-1345	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13657
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BD-93-AM31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232608
PMC12198892-pi-2025-0101-Supplementary-Material.pdf-45-KCNIP3_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE122711_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX9	ChEA Transcription Factor Targets	1.0	null
gray	GeneRIF Biological Term Annotations	1.0	null
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.62507
DY 131	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
SLC38A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00556081
BRD-K33283629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29712
TFAP2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530648
Posterior hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01273
PRKACB_knockdown_91_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.66838
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.884399
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50849
BRD-A79768653_sirolimus_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.51015
BRD-K24984327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39142
GSE225656_2_v_3_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
posterobasal nucleus, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01326
Tiplaxtinin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.76072
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN1_n_EN1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20526256_HG-14-10-04_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7166-01A-12R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GA-01-EO66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.244339
bacteroid-containing symbiosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.562
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
JD-58-MV19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370477
GSE215351,GSE215794_4_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZFP91	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0062679
GATA2	ENCODE Transcription Factor Targets	1.0	null
NCI-H716	GDSC Cell Line Gene Expression Profiles	1.0	3.60177
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24872
BRD-K14327064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54502
actin binding	GO Molecular Function Annotations 2025	1.0	null
Congenital muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE73561,GSE73563_0_v_1_mef2c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18402224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20483
Perturb_18102_KO_Tbx20_SRP007579	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K20138377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45421
4956_MED6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.531585
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96663576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51009
GSE89767_1_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.91611
MAP2K3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566441
BRD-K27823380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18802
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JA-23-QE71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248142
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HS 683	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08236
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05943
anteroventral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48935
GTEX-XPVG-0326-SM-4B653	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39209
IFNA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00686093
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	324.2
CD19+_BCells(neg._sel.)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.51615
Blood-nampt neutrophil	Tabula Sapiens Gene-Cell Associations	1.0	-0.190252
A172	BioGPS Cell Line Gene Expression Profiles	1.0	0.924528
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BX-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228106_0_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-2576-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49865102_PD-0325901_A549_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.804
Lung adenocarcinoma_LUAD_TCGA-91-A4BD-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0442
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD4_Memory_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.37358
DEL	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.08525
pioglitazone_rattus norvegicus_gpl341_gse21329	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229611
BRD-K70735803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32935
Lateral root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.958
UACC-893	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.839772
GTEX-XUYS-0126-SM-47JWZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06621
BRD-K22546959_N-(4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide CT-07_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Huntington's Disease_Brain_GSE3621	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.96197
BRD-K24178822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18385
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
zinc ion binding	GO Molecular Function Annotations 2025	1.0	null
MB21D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10239
metoprolol-2543	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K91191855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10514
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
DC-23-UM36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.387055
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.337
BRD-K05104363_PD-184352_MCF10A_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K31542390_Mycophenolic acid_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NR5A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00696201
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3129
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.05535
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049986
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12184916_NVP-BEZ235_HS578T_3_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06774
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055548
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04446
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HF-91-IU60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.293529
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
SLR25	CCLE Cell Line Gene Expression Profiles	1.0	1.40093
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.94966
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900009
SERPINB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00581631
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.321
BRD-K13781734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22489
BRD-K28030757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36191
globe disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.221793
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5176
Brain Diseases	CTD Gene-Disease Associations	1.0	1.22664
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.926118
liver cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071086
HOXB4-20404135-EML-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.703911
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18282
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	1.0	2.61695
Right_Atrium	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.47513
hsa-miR-561	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
BRD-K02708799_GSK-1059615_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO-783	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.3775
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2549
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303595
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LY-01A-31R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.58554
GATA3_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA6-21074721-CACO-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24132293_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
carbamoyl-phosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.143
lateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17267
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23303
BRD-K28360340_TW 37_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
kawain-2337	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.917201
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.553
BRD-K86269644_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
7439_RPL15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.58228
BRD-K01991250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72137
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210101,GSE210114_11_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.891295
Primary root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.965
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.615
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.843042
9328_TRRAP_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23325
BRD-K85402309_dovitinib_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
4716_LUC7L3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.33909
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.854202
BRD-K49865102_PD-0325901_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ventromedial hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10647
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE249544,GSE249637_8_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EK-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.40209
H-1152	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
TYRO3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00447234
BRD-K19133474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41772
OCT4-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE173997_1_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mss4-like	InterPro Predicted Protein Domain Annotations	1.0	null
SHSY5Y	CCLE Cell Line Gene Expression Profiles	1.0	1.6958
GSE118794_5_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3184
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23584
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.4807
BRD-A39969961_Eplerenone_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.37582
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
CSF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00886042
GSE239578_0_v_6_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8444
lateral hypothalamic area, anterior region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.91023
FDCSP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620256
BRD-K95895516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01233
GCM2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7212
NPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21495
Flagellate	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.207
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE199255,GSE199356_6_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.970218
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRAF_druginhibition_175_GSE42872	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.77279
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-25-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262188
layer 6a of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52536
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KIR2DL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00396005
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.17273
BRD-A89947015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38695
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.05352
GTEX-WK11-0626-SM-3NMAV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61448
SBK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00829327
GSE205163,GSE205164_1_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPMI8226	CCLE Cell Line Gene Expression Profiles	-1.0	-1.9874
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21853
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
subthalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.46406
BRD-K57080016_selumetinib_MCF10A_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Edema	CTD Gene-Disease Associations	1.0	1.29164
Rigid spine muscular dystrophy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.659
JA-79-II25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249938
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
benzethonium chloride-2508	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nitrate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.7
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43S-01A-21R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K12853587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93227
Lung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.907525
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular component organization	GO Biological Process Annotations 2015	1.0	null
TBC1D4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16764
BRD-K01436366_XMD-1150_LNCAP_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K97274161_N-{2-[benzyl(isopropyl)amino]ethyl}-4-({[(4-methylphenyl)sulfonyl]amino}methyl)benzamide_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206473
SEMA3F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00768739
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.987315
Microgametophyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
dorsal part of alar p3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9551
BRD-K18812295_Chrysene-1,4-quinone_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HNFA-21074721-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K11812419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41885
thioredoxin	GeneRIF Biological Term Annotations	1.0	null
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.97687
GSE102505_6_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-TKQ1-1026-SM-4GICL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19616
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K27726273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19915
H3K79me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1979
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897053
GSE123825_0_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.62375
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.38872
GTEX-W5WG-1826-SM-4KL2Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824062
NDUFA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00375752
GTEX-XPVG-1426-SM-4B668	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11972
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.95122
E2F4	ENCODE Transcription Factor Targets	1.0	null
HBMEC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LY 364947	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
liver_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.08454
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20814
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33586
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15706
BRD-K36997940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27853
BRD-U51024685_HG-6-64-01_A375_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060162
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7493
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052896
Anteromedial nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31735
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3107
W-13 HCl	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.37737
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K74514084_pazopanib_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDE4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566898
r5 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32716
GSE186483_6_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.876
GTEX-XV7Q-1226-SM-4BRVT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858209
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-gene_short_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62837
D-542MG	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.4494
BRD-K33197627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4563
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3759
dorsal tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19114
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.86285
Left_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.936915
Cognition	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K62533881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08905
BRD-A03623303_METOPROLOL TARTRATE_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-590-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
RAD21	ENCODE Transcription Factor Targets	1.0	null
BRD-K81651477_Parthenolide_HA1E_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10538
PMC5732738-oncotarget-08-103415-s002.xlsx-MFC-7_DEGs-Genes_with_significantly_different_expression_between_parental_MCF-7_and_GATA3_WT_clones_with_adjusted_P_value_0_05_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
TP53BP1_KD_GSE54268_669_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6825
Atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.12733
parasubthalamic nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45844
regulation of gene expression	GO Biological Process Annotations 2015	1.0	null
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31933
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A72703248_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE184087_2_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
OCT4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-FC-A66V-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AE-04-SN76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272012
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.892614
BRD-K59913416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59789
hsa-miR-4687-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
NCI-H1299	COSMIC Cell Line Gene Mutation Profiles	1.0	null
4945_MED22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.75066
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JL-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
protein complex assembly	GO Biological Process Annotations 2015	1.0	null
BRD-K81575721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55593
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
LY 344864	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.44
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE118794_2_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9399_TTI2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.505829
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7730811-13148_2020_983_MOESM1_ESM.xlsx-Table_S3C_HNF4A_Target_Genes-Table_S3C_HNF4A_Target_Genes_Average_Colon_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR3C1	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
8431_SRSF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.619353
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
CCNT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00505935
5910_NXF1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.657202
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43558
RCOR1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMK-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.59653
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.16276
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.57955
Anteromedial visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08119
HMGN3	ENCODE Transcription Factor Targets	1.0	null
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23442
BRD-K81651477_Parthenolide_A375_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5881-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49865102_PD-0325901_HT29_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K34519170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17927
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K71755056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27786
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AA-68-OJ16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273573
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.86208
GSE174498,GSE174500_0_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
BA-84-WN26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241027
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.11471
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.459554
cellular component assembly	GO Biological Process Annotations 2015	1.0	null
GSE158834_1_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A36275421_MW-ras12_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U3ZN-2326-SM-3DB7W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951088
A704	CCLE Cell Line Gene Expression Profiles	1.0	1.53586
BRD-K86964464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0383
BRD-K19295594_-666_A375_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSK3B_KD_GDS4305_179_human_HL-60 acute myeloid leukemia cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35076
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
zinc ion binding	GO Molecular Function Annotations 2015	1.0	null
GSE155305_2_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ND-39-PO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.53112
GTEX-N7MS-1626-SM-3LK5F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22898
hsa-miR-4690-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
trichostatin A-6171	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
19305503-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XV7Q-1026-SM-4BRVR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10268
Methionine sulfoxide	HMDB Metabolites of Enzymes	1.0	null
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062379
NCI-H524	GDSC Cell Line Gene Expression Profiles	-1.0	-1.90327
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K94441233_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5068-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-U60236422_WH-4-025_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-4713-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4694-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.527928
59M	CCLE Cell Line Gene CNV Profiles	1.0	1.56624
BRD-K52075040_-666_SKMEL28_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCND1-20090754-RETINA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PU.1-20513432-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE225901_2_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T6MO-1626-SM-32QOM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01976
Sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K09951645_dabrafenib_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.807711
CPC-N	GDSC Cell Line Gene Expression Profiles	-1.0	-1.72253
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.66905
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
sensitive	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26646
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MF-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K37454185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3547
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.27924
QA-98-TQ46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.241529
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051718
CYP4F3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00826357
actin polymerization or depolymerization	GO Biological Process Annotations 2023	1.0	null
GATA6-21074721-CACO-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
THP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61431
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28358
GSE218060_5_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11875
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
especially	GeneRIF Biological Term Annotations	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10206
BRD-K56653679_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
SCA7_Knock-in_GDS3545_560_mouse_Cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K98548675_Parthenolide_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.525915
WWP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45658
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SNU503	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37515
C7orf50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38281
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22474
GTEX-WL46-0926-SM-3LK7T	GTEx Tissue Sample Gene Expression Profiles	1.0	2.60306
BRD-K84514454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03451
Photosystem	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.026
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Ciliary body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.914
GSE153189_2_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
lingual gyrus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.844795
BRD-K53414658_tivozanib_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5678-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09685
BRD-K76251351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78254
GTEX-VJYA-0526-SM-4KL1R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01206
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87737963_CYT387_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.988977
CTCFL	ENCODE Transcription Factor Targets	1.0	null
Cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.984
SIGLEC12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00855809
iron-sulfur cluster transfer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.748
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.491597
GTEX-QXCU-0626-SM-2TC69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910665
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.785628
GTEX-S3XE-1726-SM-3K2AM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32487
CDX2-21074721-CACO-2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.85272
BRD-K47869605_PODOFILOX_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TIGIT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00667807
almost	GeneRIF Biological Term Annotations	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.478805
Urothelial carcinoma_Urothelium_GSE3167	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.68573
BRD-K84158675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20551
DUSP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00437487
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cas1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.251
BRD-K62459624_T5212475_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K60297835_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TBL1-22424771-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92598
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4930_MED10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.55985
KMS21BM	CCLE Cell Line Gene Expression Profiles	-1.0	-2.43152
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN2_n_EN2	Rummagene Transcription Factor Associations 2026	1.0	null
REST-18959480-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
G84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4465
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
downregulated	GeneRIF Biological Term Annotations	1.0	null
BRD-K94176593_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VGLL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00517473
integrity	GeneRIF Biological Term Annotations	1.0	null
mantle zone of PHyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16167
MTA3	ENCODE Transcription Factor Targets	1.0	null
ependymal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.401386
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14001
MORCPR	CCLE Cell Line Gene CNV Profiles	1.0	1.54341
Vaginal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.874
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1303
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20553
BRD-K68618894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84947
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.645913
D425	DepMap CRISPR Gene Dependency	1.0	4.31604
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4161
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.57017
Isovaleric acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078149
BRD-K64642496_-666_JHUEM2_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
non-syndromic X-linked intellectual disability 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21805
GSE249544,GSE249637_8_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Infective endocarditis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.426
BRD-U07805514_saracatinib_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.78654
GTEX-S32W-0626-SM-2XCBG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33461
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.01724
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866861
thioredoxin-disulfide reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.393
UNC5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00627386
BRD-K39449566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0557
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
KMS12BM	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47334
GSE256181_2_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
UNC2250	DeepCoverMOA Drug Mechanisms of Action	1.0	0.71
3541_GRPEL1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.526629
ASAH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00414053
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6II-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3383-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05299
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K53662389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11525
stomach	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061624
GSE176008_8_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
2983_FAU_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.741512
dermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109609
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26774
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H3-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K51805276_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-L9-A443-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mcf7	HPA Cell Line Gene Expression Profiles	1.0	0.95772
hsa-miR-219-2-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39337
POLR3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13624
BRD-A48237631_MITOMYCIN C_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T2IS-0926-SM-4DM5B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04358
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A52E-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-720	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOX10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00425217
GTEX-UJHI-1526-SM-3DB99	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933877
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TR-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0094
mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-VUSG-2526-SM-4KL1V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855375
Sulindac Metabolic Pathway(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
DOHH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00567046
BRD-K05673000_Dicloxacillin sodium salt hydrate_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FCRL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00728093
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.567
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DOCK10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0067072
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MDA-MB-175-VII	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.62773
Autosomal recessive osteopetrosis 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26257
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
znf217_22593193_mda_mb_231_gof_human_gpl570_gse35511	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.016781
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.12353
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-ID_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
lumicolchicine-1317	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-UJHI-0626-SM-3DB8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60924
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
pronephros	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24486
BRD-K68257831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72639
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K02921955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24632
BRD-K49865102_PD-0325901_A375_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5554
Medial habenula	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.7294
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.911799
OLIG2	ChEA Transcription Factor Targets	1.0	null
BRD-K79090631_CGP-60474_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Tear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.79
ETV2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3602
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15716662_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PM20D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00683532
BRD-K42091424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17305
TTC709	DepMap CRISPR Gene Dependency	1.0	5.8402
18794137-SuppTable1a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-PWOO-0626-SM-48TZH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06835
Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69852452_7241-4207_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-O5YT-0126-SM-48TBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862365
GSE218060_7_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SB 525334	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.69
BRD-K13436682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09113
heart muscle	HPA Tissue Protein Expression Profiles	1.0	2.08237
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02251
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0006
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE189834,GSE189836_1_v_0_brd4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.924838
NCI-H1299	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71504
SPI1	ENCODE Transcription Factor Targets	1.0	null
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75364
HOXB4-20404135-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K57282030_JW-7-24-1_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_OV7_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S32W-0826-SM-4AD5Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986043
Perturb_6975_OE_Alox12_SRP320989	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.68817
NCIH1930	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43611
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LE-81-PG11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260088
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
STAT3	ENCODE Transcription Factor Targets	1.0	null
Chloroplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.487
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.787
BRD-K82224868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03334
BRD-K77987382_MEBENDAZOLE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
M14	BioGPS Cell Line Gene Expression Profiles	1.0	1.64888
GSE130246_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K64992851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32189
nucleus of the stria medullaris (prethalamic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95328
Weight Loss	CTD Gene-Disease Associations	1.0	1.34694
Leukemia_promyelocytic-HL-60	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.12128
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H520	GDSC Cell Line Gene Expression Profiles	1.0	2.07988
layer 2 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20589
BRD-K86958018_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
3980_HSPA9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.683978
KPNYN	DepMap CRISPR Gene Dependency	1.0	2.92549
TPSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36561
TCL1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0062098
Very long chain acyl-CoA dehydrogenase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GINM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41554
BRD-K99545815_PF-562271_HME1_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.52133
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
P300-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A45889380_QUINACRINE HYDROCHLORIDE_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CARD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94842
GSE143499_0_v_1_gata6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STK25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24278
GSE160765_2_v_1_twist1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XCL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00542801
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
Pictilisib	DeepCoverMOA Drug Mechanisms of Action	1.0	1.05
2537_EIF2B3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.59776
PHF8	ENCODE Transcription Factor Targets	1.0	null
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.02758
GSE151612_0_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Silver ion transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.923
flumetasone-2551	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TE4	DepMap CRISPR Gene Dependency	1.0	2.24424
CADOES1	CCLE Cell Line Gene Expression Profiles	1.0	2.25798
T3M4	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.09394
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07596
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ROCK_INHIBITION_GDS3944_464_mouse_Forebrain astrocytes - 24 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
EP300_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-Q2AI-0226-SM-48U1D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906651
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2926
CID-2745687	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
Eisosome filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.243
BRD-K66110520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12146
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15789
GSE203158_0_v_13_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68548958_-666_HA1E_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.582753
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
Congenital myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
lymphoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.158257
9592_UNC45A_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.32258
dorsomedial part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28742
GAL3ST2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00599395
PL45_PANCREAS	CCLE Cell Line Proteomics	1.0	3.90418
Huelle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.264
MEWO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
APOL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00492622
POU5F1-16518401-CHIP-PET-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
smooth	GeneRIF Biological Term Annotations	1.0	null
Stomach	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.580603
EIF2S3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02955
BRD-K88472400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45042
Methionine de novo and salvage pathway	WikiPathways Pathways 2024	1.0	null
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JW-1626-SM-3GADZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41301
BRD-K50660797_EPICATECHIN MONOGALLATE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10299
BRD-K78599730_manumycin A_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.988586
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20426
EBF1-22473956-BONE-MARROW-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
layer 6a of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3155
MYO1F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00837958
embryoday8.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.28378
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A5UA-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.861404
MZ7-mel	GDSC Cell Line Gene Expression Profiles	1.0	1.73097
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.977972
Lung squamous cell carcinoma_LUSC_TCGA-66-2768-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hyperhomocysteinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02965346_SU-11274_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1648	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46179
BRD-K28950508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21495
aorta	GeneRIF Biological Term Annotations	1.0	null
tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47321
DF-93-BT88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329738
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
seriously	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-3606	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GTEX-XPT6-0226-SM-4B65L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27383
Lysosomal lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.81
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25237
BRD-K32686643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09096
GSE138468_3_v_6_dyrk1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A79465854_auranofin_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K94993773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74559
GSE109140_0_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158502,GSE158506_3_v_0_fat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K28392481_AZD4547_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1117
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.949021
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PAP-1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.613535
H3K36me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2543_EIF2S3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21833
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.58971
PMC10809641-DataSheet3.pdf-260-MSANTD4_MSANTD4	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2939-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.3323
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE136894_2_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Thomsen disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.007
STAT1	ENCODE Transcription Factor Targets	1.0	null
Eccrine sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.58
FCGR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520957
system	GeneRIF Biological Term Annotations	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
GSE246461,GSE246463_5_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77014406_4-Isopropoxy-2-(3-methoxy-phenyl)-quinazoline BRD-K77014406_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K28392481_AZD4547_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Epimastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.598
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.46446
GTEX-QDVJ-0426-SM-2I5FW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.349
NCI-H2110	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
msrb	GeneRIF Biological Term Annotations	1.0	null
Efflux pump complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.658
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.507282
GTEX-RTLS-0826-SM-2TF5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2556
KLF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.793
GSE196671_5_v_0_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9426_TUBGCP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.782665
BE-27-RQ61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.522887
7523_RPS3A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532321
GSE149010_0_v_4_dars2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06513
FCGRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0196
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.36526
intermediate stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19077
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.233162
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Macrolide transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.068
7540_RPSA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.822412
Perturb_4582_OE_H3_SRP135904	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.5529
GSE217526_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TC-95-IR96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208623
anterior paraventricular nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92424
forestomach	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.260945
WSU-NHL	GDSC Cell Line Gene Expression Profiles	-1.0	-1.76515
BRD-K21635266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79629
GSE225901_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cation binding	GO Molecular Function Annotations 2015	1.0	null
LP-533401	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319009
2747_ESYT1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.952982
CEBPB_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Stria vascularis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.614
sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.201635
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
NR2F2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158715_2_v_4_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QCQG-0426-SM-48U29	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89113
Hypertrophic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K79259477_KIN001-265_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DE-58-OW37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261383
GSE186440,GSE186443_0_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
rt4	HPA Cell Line Gene Expression Profiles	-1.0	-0.932271
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67Q-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07961
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059521
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
GTEX-XQ8I-1626-SM-4BOOI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08226
NANOG	ChEA Transcription Factor Targets	1.0	null
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K36me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Field CA2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14507
MZ7-mel	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.78744
BRD-A93942655_NCGC00188535-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78603273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22523
PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54233340_Dorsomorphin dihydrochloride_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AD-30-OK99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265017
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K28296557_Akt inhibitor IV_THP1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE103124_1_v_0_bmpr1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
shell of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61878
GSE111102,GSE111105_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MF-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K03875473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14715
ZFP281-18757296-E14-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
nucleic acid binding transcription factor activity	GO Molecular Function Annotations 2015	1.0	null
BRD-A25775766_Securinine_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Glycogen granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.325
GSE198165,GSE198166_8_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959939
BRD-A93000692_CIGLITAZONE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ARHGDIA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00676391
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nucleus of Darkschewitsch, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.43581
Root hair	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.542
BRD-K74733595_A2478_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XBEW-1426-SM-4AT4J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922521
H3K79me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
VPS13B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00905706
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21722
BA-59-EN38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229307
GSPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1856
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	129.027
BRD-K63800697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59965
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27561
BRD-K12502280_TG101348_NCIH596_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LIPF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00617049
GSE188870,GSE188871_1_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dasatinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.88
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.55861
BRD-K87909389_alvocidib_HME1_3_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE136591_0_v_1_akap11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE84175,GSE84176_0_v_1_ctcf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1666
Fibrosis	CTD Gene-Disease Associations	1.0	1.53283
Pilus tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.051
ODF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10075
mitochondrion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.521841
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
molt-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.886286
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	108.134
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.82534
lens fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.609332
GSE173997_3_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
TPCA-1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.83
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07472
BRD-K15293421_NCGC00241071-01_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K95569142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26293
BRD-A35869383_ibrutinib_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
differentially	GeneRIF Biological Term Annotations	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
Xylem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.142
BRD-A71590475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73852
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abundant	GeneRIF Biological Term Annotations	1.0	null
BRD-K17421394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24418
16455954-TableS2	GeneSigDB Published Gene Signatures	1.0	null
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333793
Tonsil	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.32279
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRIM24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599681
BRD-K37014934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3635
Hypothalamic medial zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08452
testis_7f	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.824965
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.24545
BRD-K10232513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03721
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.661783
medial mammillary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44795
Osteosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
BRD-K82868643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16502
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CPNE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14157
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4942_MED1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.707391
GSE148066,GSE157787_8_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.144
GSE168807_0_v_8_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bladder	GeneRIF Biological Term Annotations	1.0	null
DUOX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00644983
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.34732
5649_NFKBIE_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.546115
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211525
regulation of cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
cysteine	GeneRIF Biological Term Annotations	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.03308
PMC4909989-ncomms11840-s2.xlsx-down-regulate-TEAD4-S_YAP_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153189_2_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
bergapten	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46243
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01852
NCIH1299	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70136
HCC366	CCLE Cell Line Gene CNV Profiles	-1.0	-1.90382
STAT3-24763339-IMN-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.01483
interstitial cystitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.824538
Postsubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20766
loss	GeneRIF Biological Term Annotations	1.0	null
DAGLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21949
NCIH716	CCLE Cell Line Gene Expression Profiles	1.0	2.59584
Adrenocortical carcinoma_ACC_TCGA-OR-A5J2-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K51196703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4151
GINS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00361087
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE96641_5_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04558
Perturb_8876_KD_ABCB6_SRP309466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.24199
CRCGN008_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.334
NT5C3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00609329
mantle zone of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74652
GGA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22886
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.84239
PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_18_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ASH2L-23239880-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12621
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60405
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.941916
IL15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502138
ZNF667	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32937
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11946
PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3B-Up_Dpy30_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PLZ6-0826-SM-3P61K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82954
BE-73-KD75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251943
BRD-A24396574_celastrol_MDAMB231_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rosiglitazone-1174	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A10715913_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A31159102_prozac_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lower basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.80986
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19824
Learning Disorders	CTD Gene-Disease Associations	1.0	1.22339
BRD-K80431395_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5105
Hypoxia_Astrocyte_GSE4483	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.741768
GSE58724_3_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PW2O-0826-SM-48TC5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00657
GSE228261_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cell envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.522
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14457
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE145215_0_v_1_krt13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XUJ4-2126-SM-4BOOX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03088
BRD-A29082194_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K03406345_azacitidine_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ABI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00681793
BRD-K11389666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44847
layer 6b of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3926
GSE102467_3_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QV44-0526-SM-2S1RE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47352
GTEX-X5EB-2226-SM-46MW4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919479
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86523
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4841-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73789395_ZM 336372_PL21_6.0_h_102.71_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MOLT-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.001
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.591666
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A519-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trigeminal	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.834561
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K32195266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28434
bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.578106
UM-UC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30682
Penis_Foreskin_Melanocyte_Primary_Cells_skin01	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.890104
BRD-K56301217_A112550.cdx_HCC15_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K33705415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05995
BRD-K49865102_PD-0325901_A375_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RAC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00347096
mantle zone of PHyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35134
Crizotinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.69
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE97352_1_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70237115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72717
Haustorium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.872
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968519
A 922500	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.22
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.316
MAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00453144
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K28803288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95235
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.0836
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21207
TFAP2C_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF8-20622853-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K09295309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22837
cefadroxil-3259	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPMI-8226	GDSC Cell Line Gene Expression Profiles	-1.0	-1.94769
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80V-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22693
BRD-K93900188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48822
BRD-K15373812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52335
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.880877
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RJ-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13321
BRD-K68185022_Ursolic Acid_A375_24.0_h_70.07_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Nutritional deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.279
Lung squamous cell carcinoma_LUSC_TCGA-98-8022-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-GATA3_only-Gene_Name_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.751271
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.578833
FPR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571749
BRD-K50168500_S1019_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37118
GTEX-P44H-0526-SM-2XCF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89974
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.52675
BRD-K82484347_GSK-J2_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K89377615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35163
lysosome	LOCATE Predicted Protein Localization Annotations	1.0	null
KA-63-FH23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.410547
Photophore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.867
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.554453
substantia innominata, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.895518
BRD-K76713298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40703
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12938
BRD-K99749624_linifanib_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4701-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13297
Lung squamous cell carcinoma_LUSC_TCGA-37-3783-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
peptide-methionine (R)-S-oxide reductase activity	GO Molecular Function Annotations 2023	1.0	null
3818_HMBOX1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.736053
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
absent	GeneRIF Biological Term Annotations	1.0	null
superficial stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1677
Prostate adenocarcinoma_PRAD_TCGA-J4-A67N-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02708799_GSK-1059615_A375_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3212
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10177
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.952346
BMI1_DN_MEL18_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GTEX-OHPM-0326-SM-33HCA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47518
BRD-K74305673_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K02407574_Parbendazole_A375_24.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8405683-41419_2021_4120_MOESM2_ESM.xlsx-Sheet1-Table_S2_MYCN-responsive_gene_list_1_5_fold_p_0_05_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72462751_C-1_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Keshan disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.781
CTCF_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210951_1_v_0_islr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPTBN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00592968
Type IV pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.728
8621_SYMPK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.551257
posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.839483
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SN8G-0126-SM-32PLI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27354
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28867
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.601272
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.798196
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386959
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-XG-A823-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30216
BRD-A18328003_GDC-0980_HS578T_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE86021_0_v_3_crenolanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
type	GeneRIF Biological Term Annotations	1.0	null
BRD-K76703230_YM-155_A375_24.0_h_0.31_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69859
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.900558
PMC8200296-LSA-2020-00928_TableS2.xlsx-table_s2_DEGs_log2foldchange_0-Table_S2_List_of_DEGs_induced_by_YY1_knockdown_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00758943
GSE134029_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.772
hsa-miR-4282	TargetScan Predicted Conserved microRNA Targets	1.0	0.598666
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R53T-0926-SM-3GADH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48319
hsa-miR-3169	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIGLEC11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00637341
CD56+_NKCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.01649
Parataenial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46677
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0382
HDLM-2	GDSC Cell Line Gene Expression Profiles	1.0	1.96851
PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K36me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Papillary Carcinoma of the Thyroid_Thyroid Gland (MMHCC)_GSE3678	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.71453
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67406
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.39013
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.5712
GTEX-PLZ5-0626-SM-2I5F8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984817
adrenalgland	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.898514
BRD-K32644160_UZI/1930680_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRAF_druginhibition_38_GDS5085	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.77279
NCI-H250	GDSC Cell Line Gene Expression Profiles	1.0	1.65573
YF-77-FV50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.402009
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.18873
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.838109
CEP95	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02142
ELF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00643018
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYEOV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00708755
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28473
t-lymphoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.585625
7217_RDH14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562862
H3K36me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_1_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K53414658_tivozanib_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
NOC3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01611
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50392
ChIP_NR0B1_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-A60245366_AS-601245_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SNMC-0426-SM-4DM5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853784
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-SIU8-0826-SM-2XCDQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32513
Infralimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0501
BRD-K30381304_OSSK_645668_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ARHGAP25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00540841
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SNAI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604124
habenula (old epithalamus)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73559
Perturb_7106_OE_Erbb2_SRP245626	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47W-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CENP-A recruiting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.691
SW-48 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	153.581
CA4 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.63862
BRD-A18763547_-666_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAD21	Pathway Commons Protein-Protein Interactions	1.0	null
CEBPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00679147
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.06735
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
phenothrin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66017
GTEX-RVPV-1226-SM-2TF73	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04945
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05806
DPS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.47
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.42974
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GTEX-UPK5-0226-SM-3GAEV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2157
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41885
GTEX-RTLS-1226-SM-46MUP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853479
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64942
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.74352
BRD-K99475920_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
4960_MEF2A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.662947
GSE149359_2_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
RPMI 8226	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.86123
zinc ion binding	GO Molecular Function Annotations 2023	1.0	null
protein binding	GO Molecular Function Annotations 2015	1.0	null
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.30183
AA-58-FJ71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.61802
6276_PHB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00861
BRD-A60245366_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	856.863
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.4481
HCFC1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24006
BLTP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00576695
16166618-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.938555
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Ensembl_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Ciliary body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K46195730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64283
UB-41-DY23_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247932
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A79768653_sirolimus_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
plant-type vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.923
BRD-K06181161_Carbetapentane citrate_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SMG7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00725471
GTEX-RWS6-2026-SM-2XCB5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924654
BRD-K49865102_PD-0325901_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
follicle	GeneRIF Biological Term Annotations	1.0	null
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1984
NBTGR	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.21
Mammillary body	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39801
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.37019
Mitochondrial mRNA editing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.801
Lung adenocarcinoma_LUAD_TCGA-86-A4JF-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BT20	CCLE Cell Line Gene CNV Profiles	1.0	2.04298
CCLFUPGI0005T	DepMap CRISPR Gene Dependency	1.0	4.37349
geldanamycin-6187	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-R55E-1026-SM-2TC5S	GTEx Tissue Sample Gene Expression Profiles	1.0	3.19959
BRD-K60758969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56476
AA-62-HP31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2789
Cytochrome o ubiquinol oxidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.807
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_24_human_DRSG_higherRes-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.846443
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01817716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19229
HS766T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59596
acute lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.483206
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43367
BRD-K57556489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48629
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290187
hsa-miR-654-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
KCNK12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00365355
REST_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LY9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00673876
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.46844
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SETDB1_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148066,GSE157787_3_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14414396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.80942
AKT_UP_MTOR_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
NCIH1693	CCLE Cell Line Gene CNV Profiles	-1.0	-1.89887
t70-white-adipose_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.86682
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.383359
DCLRE1C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00451642
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DENND1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0052663
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26163
BRD-K05804044_AZ-628_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0748
ZNF766	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4813
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
medial subhabenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40883
AZ 628	DeepCoverMOA Drug Mechanisms of Action	1.0	1.24
SR 3335	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.89
BRD-K78978845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20428
overexpression	GeneRIF Biological Term Annotations	1.0	null
BRD-K70584304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46029
SOX10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6268
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79814
BRD-K31633810_DAU 5884 hydrochloride_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CyPPA	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.57
BRD-K02130563_S1030_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K88573743_A443654_HME1_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PSDG-0226-SM-33HC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89786
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34264024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1777
Fumarate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.841
Mitochondrial inner membrane peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.114
BRD-K43389698_BMS-387032_HS578T_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060328
496100296_PCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.1088
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.03367
MARCKS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00475112
VAMP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510992
Mobitz type II atrioventricular block	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.087
SBK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572886
BRD-K08939002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17858
medial parabrachial nucleus,right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.867884
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A5UD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EHMT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00451445
GE-34-TW62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00735
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01133
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900403
transition metal ion binding	GO Molecular Function Annotations 2023	1.0	null
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20415826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68007
hair	GeneRIF Biological Term Annotations	1.0	null
BRD-K94888615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27377
RTEL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558632
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38233
Acute Myeloid Leukemia_LAML_TCGA-AB-2985-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07485
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62964
BRD-K90524085_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DUSP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537324
GSE205163,GSE205164_3_v_0_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.7959
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03352270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76322
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.14362
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
accumulation	GeneRIF Biological Term Annotations	1.0	null
peroxide	GeneRIF Biological Term Annotations	1.0	null
BRD-K07881437_S1107_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K52154207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28349
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Primary somatosensory area, lower limb, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13182
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-K1-A3PN-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91836367_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IC-80-CT90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211864
IGFBP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496433
NU7441	DeepCoverMOA Drug Mechanisms of Action	1.0	1.2
Disease Models, Animal	CTD Gene-Disease Associations	1.0	1.47889
Right atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.26686
lateral part of the lateral habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92966
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48685
HCT-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896615
gp16	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.575
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BLNK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664422
FASN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74781
BRD-K20495487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02116
FAM8A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11775
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.417818
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_3_TurboID_1hr_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
Antipodal site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.665
2236_DLAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.66257
GSE203329_2_v_3_mettl5_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H520	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.98298
BRD-K21423050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09244
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
layer 3 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13008
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
basal part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28406
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84232
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GYPC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613508
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.312232
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Eye-cd8-positive, alpha-beta t cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.190252
GTEX-U3ZH-0326-SM-3DB7A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4707
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.539032
8653_TAF12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.594013
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04979
3980_HSPA9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512924
mantle zone of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74074
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.916493
BRD-K92428153_MYCOPHENOLATE MOFETIL_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	339.641
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.34195
BRD-U86922168_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28168037_Fenretinide_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K29143088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41239
GSE123825_0_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CE-15-YU05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254284
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
BRD-K14618467_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.743378
BRD-A22783572_Vinblastine sulfate_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABRB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00626758
BRD-A46186775_HYDROCORTISONE PHOSPHATE TRIETHYLAMINE_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05238
KCNMB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00474913
DCTN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72191
BRD-K24132293_PIPLARTINE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55515
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	1.0	1.0085
BRD-K09598619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9795
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829329
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K20846358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5006
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.364
mantle zone of PThE	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9551
Dorsomedial nucleus of the hypothalamus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.87196
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12581
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42278
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8274
Endomyocardial fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
NXPE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0100686
GSE164757,GSE164759_1_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10337103-13046_2023_2747_MOESM2_ESM.pdf-25-ENSG00000137504_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
testis_7e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.14644
Heart Diseases	CTD Gene-Disease Associations	1.0	1.10527
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1651
EWP-815	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
GPI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02601
SMC3	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-371-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
4-Methylhistamine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.4
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1955
cellular process	GO Biological Process Annotations 2015	1.0	null
BRD-K33606137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85692
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SUCS-0326-SM-32PLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08667
GTEX-WYJK-1026-SM-3NM8W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79898
BRD-K74402642_Chemistry 2804_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K03736784_-666_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UI-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
Fbxl10_OE_GDS4788_327_mouse_MEF fibroblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
BRD-K82571240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73257
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.59504
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210662_2_v_0_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-1.06452
Brain - Hypothalamus	GTEx Tissue Gene Expression Profiles 2023	1.0	1.16863
Prostate adenocarcinoma_PRAD_TCGA-HI-7169-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2013
RBM28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.44253
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K90702609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5642
OE-18-ZX28_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.34978
BRD-K19712167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44239
Paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02921
BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-11.4657
Adrenocortical carcinoma_ACC_TCGA-OR-A5K5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39987650_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5010-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Divisome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.838
BRD-K61795707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38734
lateral septal nucleus, intermediate part, periventricular	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23154
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0714
Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1934
free-living state	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
BRD-K81418486_vorinostat_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51313569_palbociclib_A375_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K28296557_Akt inhibitor IV_RMGI_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
embryonic fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109363
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GATA3-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF3	ENCODE Transcription Factor Targets	1.0	null
GTEX-XBEC-1226-SM-4AT65	GTEx Tissue Sample Gene Expression Profiles	1.0	2.10454
KARPAS299	CCLE Cell Line Gene Expression Profiles	1.0	2.94581
SLC2A4RG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00756059
GSE169205_0_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HSD17B3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0066678
Hemocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.659
BRD-K09991945_GSK-3 Inhibitor II_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE244730_0_v_1_erlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
QE-18-WG07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224193
intermediate stratum of PThE	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96076
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0019
BRD-K07303502_Arachidonyl trifluoro-methyl ketone_A375_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-607	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.4011
Anterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95328
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
liver cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065784
GSE112860_0_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.59804
BRD-K57080016_selumetinib_BT20_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8431_SRSF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.744921
BRD-A71459254_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A29082194_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WFG8-0626-SM-3GILJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40045
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K53993775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15128
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1651	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.37074
BRD-K03116010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50958
BRD-A69196860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22899
CTCF_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120370_0_v_6_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZFP281-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K81651477_Parthenolide_SKLU1_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.84954
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.355408
Carotid sinus nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
Cobalamin transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.536
Sessile cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.945
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ASIC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00513569
YDJC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00627221
BRD-K59130962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7567
BRD-K98598055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32488
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OV-90	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K26767475_NCGC00183255-01_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.454816
graywhite	GeneRIF Biological Term Annotations	1.0	null
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.13415
H3K36me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	297.352
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15838
GTEX-T5JC-1226-SM-4DM7C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30495
BRD-K33102216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44654
HCC1143_BREAST	CCLE Cell Line Proteomics	1.0	14.2504
C8orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07125
H4C9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00727906
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.21707
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0418
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RB1_KD_GSE50532_641_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069505
BRD-K07914894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41753
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
9399_TTI2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05665
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-REY6-0626-SM-2TF4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884865
LARP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85863
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261914
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	185.294
GTEX-OXRK-0826-SM-2HMK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42369
Brain microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.13
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36789
GOLGA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01713
BRD-K88510285_B675700.cdx_A549_24.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
stratum pyramidale of caudal CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02571
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	1.0	0.927563
Heart ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.263
BRD-A94756469_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K92632379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09309
Esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.112
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
NANOG-16518401-CHIP-PET-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE60837_0_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06611347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23486
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KCNK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00411189
skeletal	GeneRIF Biological Term Annotations	1.0	null
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BC-61-BE07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.948469
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SYT11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00773983
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.80751
SAA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00881961
BRD-K30707190_PNU 74654_HA1E_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE108495_1_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39322
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20641
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CREB1_01_274	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.68338
EBF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-X5EB-0626-SM-46MVQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09318
Tivozanib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.48
BRD-K46641047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60737
PMC8872993-41380_2021_1274_MOESM4_ESM.xlsx-Table_S6-Supplementary_Table_S6_Differentially-Expressed_Genes_after_T-3_KD_in_hiPSC-derived_Astrocytes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K45909830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79283
ST8SIA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00536642
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35049
Protein repair	Reactome Pathways 2024	1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
POU3F4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0975
GSE217201_1_v_0_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GE-22-ME44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209255
EF-92-OO68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265005
hsa-miR-4659b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.65007
DA-10-HD17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311809
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CDK4_knockdown_225_GSE8866	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.15975
2784_EXOC7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.753405
GSE203158_0_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hyphal tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.878
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Flagellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.097
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.944358
BRD-K13662825_dinaciclib_HT29_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0488
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63251
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48903
BRD-K73304092_NCGC00011606-02_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TAF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36396
PDE5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00595157
BRD-K42828737_sutent_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K32185628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06381
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.65064
BRD-K15935639_Z-Leu3-VS_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76929
OXCT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00278381
u698	HPA Cell Line Gene Expression Profiles	-1.0	-2.39936
SUDHL10	CCLE Cell Line Gene Expression Profiles	-1.0	-2.17378
dorsal juxtacommissural pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66071
1716_CNOT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.667434
JUN	ENCODE Transcription Factor Targets	1.0	null
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	1.0	2.52109
BB-09-GD09_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277277
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34362
mantle zone of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11854
PRKAG3_Mutation (R225Q)_GSE4067_390_mouse_Skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93658967_Aloisine A_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.32463
BRD-K03440991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20591
NCI-H196	COSMIC Cell Line Gene CNV Profiles	1.0	2.59653
Histamine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
GTEX-WFG8-0326-SM-4LVN4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24837
BRD-K55612106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02461
lateral subhabenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37232
FYB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604384
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K53443314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42516
BRD-K61776140_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CH5132799	DeepCoverMOA Drug Mechanisms of Action	1.0	0.86
mitochondrial	GeneRIF Biological Term Annotations	1.0	null
PMC3805607__F3	PFOCR Pathway Figure Associations 2024	1.0	null
MRE11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03077
GSE164529_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00898593
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00231
esophagus	HPA Tissue Protein Expression Profiles	-1.0	-1.06452
eye	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PSMG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054405
496100561_PCx_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11351
LRSAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06311
BRD-K42754852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5302
BRD-K14570970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09475
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.27496
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
displayed	GeneRIF Biological Term Annotations	1.0	null
acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.124814
ribonucleoside-diphosphate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.299
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.63745
Type IV secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.356
Paraflocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00121
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981932
inner CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28127
strong	GeneRIF Biological Term Annotations	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K37527074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88553
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.53962
PMC12255818-41467_2025_61448_MOESM1_ESM.pdf-51-NFIB_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
tuberomammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.10658
H3K9me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12344
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20982
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.251
degeneration of macula and posterior pole	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.78066
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.253
Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dithiothreitol	CTD Gene-Chemical Interactions	1.0	null
GSE133213_9_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K08417745_SID 26681509_THP1_6.0_h_88.8_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T5JC-1826-SM-4DM6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01462
MC116	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66021
SFRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660965
SARS-CoV MA15_Day7-C57BL-6_None_GSE40824	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.40517
QPCT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00436762
PMC4595011-pgen.1005555.s001.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
CHRNA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00646052
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.866187
1840_CPSF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.733294
KYNU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00710008
BRD-K13566078_BMS-345541_MDAMB231_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWOO-0326-SM-48TDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931632
REST	ChEA Transcription Factor Targets	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
vacuole	LOCATE Predicted Protein Localization Annotations	1.0	null
Glycine reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.668
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43002773_GDC-0068_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.557462
TAF2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.941734
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ES-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K88038091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46256
BRD-K49865102_PD-0325901_A549_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.05691
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K88278778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13174
BRD-K49039223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41548
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10035
CIITA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00541459
regulation of nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-A26199074_2561_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K41271559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2795
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.678737
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09756
BRD-K81949875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3313
DGCR6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35395
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A46747628_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1428	CCLE Cell Line Gene CNV Profiles	1.0	1.79521
NCIH69	CCLE Cell Line Gene Expression Profiles	-1.0	-2.89817
Potassium ion-transporting ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.632
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.7084
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.78906
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.35928
BRD-K41895714_AS-605240_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A60245366_AS-601245_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A99687212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08547
BRD-K81528515_nilotinib_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Fast twitch muscle fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.751
Ethiprole	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
CD207	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00479199
amygdaloid complex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.917456
DC-93-NP78_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20869
hsa-miR-4801	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.907596
GSE217132_0_v_1_pfkfb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WYBS-1226-SM-3NM9N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17911
BRD-K43203897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07828
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_3-ZNF195_ZNF195	Rummagene Transcription Factor Associations 2026	1.0	null
regulation of rna biosynthetic process	GO Biological Process Annotations 2015	1.0	null
LN18	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54173
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.32559
BRD-K47150025_Ki 8751_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cystitis	CTD Gene-Disease Associations	1.0	1.07875
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28876
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.284
acetohexamide-1829	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TUBB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00669547
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.76239
GSE142210_11_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.801041
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70949
EIF2B5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2142
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999045
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48859
PMC9928584-41556_2022_1059_MOESM3_ESM.xlsx-Table_8-Supplementary_Table_8_ETV6-repressed_genes_defined_by_dTAG_at_72_hours_ETV6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54330070_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SUCS-1426-SM-4DM5W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30999
hsa-miR-4727-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K14431723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34364
EGR1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DAPK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00532314
GTEX-WI4N-1026-SM-3LK7N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24612
Impetigo	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880287
GTEX-QESD-0626-SM-2I5G4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920929
Tozasertib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.75
BRD-K01362004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29598
TE5	DepMap CRISPR Gene Dependency	1.0	2.33013
GSE148066,GSE157787_3_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04181
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.34242
BRD-K93975822_NCGC00183244-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K19168437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41987
BRD-K01162126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47412
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.45125
CNOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75607
Sarcoma_SARC_TCGA-K1-A3PN-02A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210101,GSE210114_0_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.7193
peptide-methionine (R)-S-oxide reductase activity	GO Molecular Function Annotations 2025	1.0	null
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84732
EKVX	BioGPS Cell Line Gene Expression Profiles	1.0	0.826875
hsa-miR-4772-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
transition metal ion binding	GO Molecular Function Annotations 2025	1.0	null
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971822
BRD-K50000283_PHA-767491_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K19800225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61469
BRD-A97759891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54251
Division septum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.981
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
MET_knockout_253_GSE30651	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.67941
BRD-A34842997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26969
GSE148262,GSE150691_1_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZD 7288	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
upon	GeneRIF Biological Term Annotations	1.0	null
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.96767
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862006
NR2F2	ENCODE Transcription Factor Targets	1.0	null
Pilus shaft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.916
Lung adenocarcinoma_LUAD_TCGA-44-4112-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.555701
hsf1_17216044_hela_lof_human_gpl571_gds1733	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.21881
MCF7	CCLE Cell Line Gene Expression Profiles	1.0	1.46115
melanocytes	GeneRIF Biological Term Annotations	1.0	null
Anterior cingulate area, dorsal part, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02367
lung cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065856
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77784
PMC9270251-mmc2.xlsx-4_Filtered_DEGs_Control_vs_KD_3-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9810535-41590_2022_1370_MOESM3_ESM.xlsx-Table_S3-MECOM_down_genes_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
Lhx8	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.6634
ALPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00684038
CENPM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29808
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r1 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22927
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.67627
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6326-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.7608
trim28_23493425_cd71pluster119plus_sorted_from_bone_marrow_lof_mouse_gpl6887_gse44063	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.901824
BRD-A09539288_HOMATROPINE BROMIDE_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K74892102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09029
GTEX-P44H-0726-SM-48TBT	GTEx Tissue Sample Gene Expression Profiles	1.0	2.35624
GSE133516_0_v_1_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
tamoxifen_homo sapiens_gpl3921_gse33366	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC11161988-12906_2024_4523_MOESM3_ESM.pdf-160-ZNF20_ZNF20	Rummagene Transcription Factor Associations 2026	1.0	null
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01815685_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LIVF001-023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09231
BRD-K37865854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23107
Probenecid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
BRD-K60093216_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE223008_7_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.67374
BRD-K50472386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21813
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306978
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.963697
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.06225
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.488247
GSE120415,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.96322
SIK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590461
SUM149PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.780145
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0245
Lung squamous cell carcinoma_LUSC_TCGA-21-5784-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KARPAS299	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
chr10_23098364_G_A_b38	GTEx eQTL 2025	1.0	1.10446
oxygen	GeneRIF Biological Term Annotations	1.0	null
ZFX-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GLB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00350539
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.21477
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.828419
STAT1-20625510-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.878
BRD-U61997977_WZ-4-145_A549_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Metabolism of proteins	Reactome Pathways 2024	1.0	null
P300-27058665-CHIP-SEQ-ZR-75-30CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
7275_RGS14_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.644535
BRD-K89767945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22525
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
weak	GeneRIF Biological Term Annotations	1.0	null
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	160.333
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.950942
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.393549
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226249_2_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44733
Anagrelide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
MAX	ENCODE Transcription Factor Targets	1.0	null
BRD-K60623809_SU11652_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KYSE-140	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.97599
NCI-H28	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-5.14428
tail of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.913881
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.867312
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.17405
BRD-K00853706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23738
Postsubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19225
496100339_HIP_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02839
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100656_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02206
FOS	ENCODE Transcription Factor Targets	1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78659596_MLN2238_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Nifedipine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.59
CMYC-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K74305673_IMD 0354_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K03406345_azacitidine_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18833
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K12613826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20342
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.48228
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A15798299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15077
BRD-K36198571_WAY 170523_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PGM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622295
BRD-K26108750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06689
Toceranib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.81
Ceritinib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.67
BRD-K49865102_PD-0325901_HS578T_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A28105619_curcubitacin I_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HS936T	CCLE Cell Line Gene Expression Profiles	1.0	1.93953
BRD-K88510285_B675700.cdx_A375_24.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K36me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H4K20me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Blood-granulocyte	Tabula Sapiens Gene-Cell Associations	1.0	-0.189685
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64857848_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
E2F7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09382
GSE226249_5_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Homocystinuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.862
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.02855
BRD-K13715646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30061
BRD-A20697603_598226_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A68930007_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K78599730_manumycin A_A375_24.0_h_9.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
periventricular stratum of JcPL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05389
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92079
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33578
PLEKHG5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28252
GTEX-UJMC-0526-SM-3GAE3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37923
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97496
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K04853698_LDN-193189_SKBR3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWOO-1026-SM-48TCN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960412
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K67844266_MLN4924_SKLU1_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2614
BRD-K98203492_GSK-J4_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.67887
Epithalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70908
estradiol-1182	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K17234088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18117
BRD-K35960502_NICLOSAMIDE_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SSR 69071	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.92
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRKAR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00500635
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.481648
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PVOW-0426-SM-2XCF8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41115
heart	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
BRD-K05734090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06962
Adrenocortical carcinoma_ACC_TCGA-OR-A5LA-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A5W4-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRO-AP2	GDSC Cell Line Gene Expression Profiles	-1.0	-2.61713
GSE109530,GSE109531_1_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K74305673_IMD 0354_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Acquired Immunodeficiency Syndrome	HuGE Navigator Gene-Phenotype Associations	1.0	null
MICOS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.661
BRD-K65737790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06312
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7DV-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K10207760_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61662457_CAY10594_HCT116_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.7009
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.826418
BRD-K43989220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17681
Peribacteroid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.565
intralaminar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03121
ZNF263	ENCODE Transcription Factor Targets	1.0	null
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0086498
Vacuolar lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.825
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.551055
GSE160246_9_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Neu-Laxova syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.749
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.42731
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYC-27129775-CHIP-SEQ-CORNEA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
JB-09-SI50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201413
BRD-K66874953_Pifithrin-a_A549_6.0_h_69.83_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2925-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24146
HCA-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65778
Lung adenocarcinoma_LUAD_TCGA-50-5044-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100663_TCx_no dementia_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.59102
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.2169
GSE87299_2_v_3_nr1d1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0643
DU-4475	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.8454
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31505
PPP2R2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50165
COLO679	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42575
GTEX-XQ8I-2326-SM-4BOQC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928994
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04558
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
DOV13	DepMap CRISPR Gene Dependency	1.0	2.74421
Becker disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
cuneiform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.978236
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NR2C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03438
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14491
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A562-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K89391146_RG 108_THP1_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-cARID1A_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64906
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68A-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
naproxen-2533	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28018
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
peptide-methionine (r)-s-oxide reductase activity	GO Molecular Function Annotations 2015	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
heart_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.66046
GSE144115_0_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A13122391_16-HYDROXYTRIPTOLIDE_SKMEL28_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ELK1	ENCODE Transcription Factor Targets	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892743
protein polymerization	GO Biological Process Annotations 2015	1.0	null
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.9588
Alosetron	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16717067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00429
4153_INTS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.690038
CDHR4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623162
t69-brown-adipose_male_8w	MoTrPAC Rat Endurance Exercise Training	-1.0	-1.91863
LMNB1_02_195	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63694
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JE-04-LS32_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244054
TFAP2A	ENCODE Transcription Factor Targets	1.0	null
BRD-K64634304_Retinoic acid_MCF7_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K08451418_5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K47869605_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65647
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE111247_2_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07544
CTCF_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4540_LDB1_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.695542
paraventricular nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.912182
Adrenocortical carcinoma_ACC_TCGA-OR-A5JX-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AE-36-JB67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228258
dorsal spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.33949
vitiligo	GeneRIF Biological Term Annotations	1.0	null
LK2	CCLE Cell Line Gene Expression Profiles	1.0	1.63645
BRD-K74096348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00917
superior colliculus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.858868
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
3220_FUNDC2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15382
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
Plant tumor tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.967
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.926764
8155_SMC1A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.564872
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.2353
KARPAS620	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76267
BRD-K87180723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57946
BRD-K48556518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05672
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.611002
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K68185022_Ursolic Acid_MCF7_24.0_h_70.07_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
LAIR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00733965
HCC1143	CCLE Cell Line Gene CNV Profiles	1.0	2.30124
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAY10550	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.8
BRD-A09988375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14607
dorsal part of alar p2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74074
NDUFA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00596566
BRD-K90052868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2213
DMD_Deficiency_GDS2996_613_mouse_Cardiac muscles from 8-week (mdx animals)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16515
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67888
BRD-K12184916_NVP-BEZ235_HS578T_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FGFBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566236
BRD-K83090041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23693
GSE112714_2_v_3_ctnnb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60219430_serdemetan_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.54634
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907273
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
ND-54-NO97_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301059
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21207
skin	HPA Tissue Gene Expression Profiles	-1.0	-1.08398
BRD-K60274257_Dephostatin_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPL26L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00702749
BRD-A19037878_trichostatin A_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
LILRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663453
GA-81-DL34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240875
BRD-K21232462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71371
BRD-K93927229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00642
RHBDD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57391
H3K9me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33153
BRD-K36616567_Doxepin hydrochloride_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE67266_7_v_3_etoposide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.575
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.93025
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836567
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15276
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3554
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15409150_PENFLURIDOL_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE240027,GSE240030_1_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-42-FF52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320799
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.0435
BRD-K24132293_piperlongumine (HPLC)_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5595
BRD-K19965080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72003
NR3C1_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A58280226_Y-27632_PC3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4c-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
GATA3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-2626-SM-4B669	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05664
SLC7A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0034145
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-U51024685_HG-6-64-01_A375_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052617
Sarcoma_SARC_TCGA-WK-A8XY-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17481
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14004
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59251
HDLM2	CCLE Cell Line Gene Expression Profiles	1.0	1.61377
PMC11653668-ADVS-11-2400133-s005.pdf-6-ZNF777_ZNF777	Rummagene Transcription Factor Associations 2026	1.0	null
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.754
tert-Butylhydroperoxide	CTD Gene-Chemical Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GR-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
sense organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE180277_0_v_1_bach2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAVER1	DepMap CRISPR Gene Dependency	1.0	2.58514
without	GeneRIF Biological Term Annotations	1.0	null
RPL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24929
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K91410469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50746
TCF7L2_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB5	DepMap CRISPR Gene Dependency	1.0	2.59643
BRD-K37595074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07252
Lung squamous cell carcinoma_LUSC_TCGA-18-3417-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SOX9-26525672-CHIP-SEQ-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Peeling skin syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A65145453_ATPA_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A52193669_2816_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K51017127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82399
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.092125
CHD2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chloroplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.650869
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.97989
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
CRCGN016_MCF10A.WT.HP_24H:I01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49157
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02822062_CT-200783_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSS008	DepMap CRISPR Gene Dependency	1.0	4.89799
BRD-K49865102_PD-0325901_HCC515_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A47513740_calyculin A_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TC32	CCLE Cell Line Gene Expression Profiles	1.0	1.8517
BRD-K90294313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40459
POLR2AphosphoS2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08096
BRD-K88378636_withaferin-a_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
AKT2_knockout_221_GSE19079	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.3163
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40564
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CJ-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MMP26	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543191
BRD-K34445094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04388
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504374
BRD-K38750802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17795
BRD-K24970278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02629
CF-24-KQ98_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230101
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate periretromammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4156
BRD-K31688005_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P4QS-1126-SM-3NMD5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900531
cisplatin_homo sapiens_gds3910	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A1-11A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7091-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.961182
BRD-K55288106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1178
BRD-K88510285_B675700.cdx_HT29_24.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A29901043_HY-11066_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TIMD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00958352
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.29169
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	61.1743
GSE62292,GSE62295_2_v_0_col4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00589
hnf1b_16297991_hek293_embryonic_gof_mouse_gpl96_gds1499	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.078573
TOR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88415
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38024
FOXA1_OE_GDS4957_144_human_LNCaP prostate cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bacterial nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.386
BRD-K46015322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02837
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6103
BRD-K92978173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03815
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.3103
intermediate part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35219
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30205
BRD-K85402309_dovitinib_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE165071,GSE165072_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.78168
5677_NIPBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.717043
BRD-K11643336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21043
Lateral septal nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06356
Microsporidian	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
msra	GeneRIF Biological Term Annotations	1.0	null
LA-42-ER00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.957464
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.39301
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.022
GTEX-OIZH-0126-SM-2HMIS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882564
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
protein repair	GO Biological Process Annotations 2023	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y5-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76664579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31985
FCGR1BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601014
BRD-A19037878_trichostatin A_HEC108_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29843
BRD-K91370081_-666_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CEBPZ_02_118	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.62449
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.416027
CRCGN011_HEPG2_24H:N20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12757
Brain - Nucleus accumbens (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.90371
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01039605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03422
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1806	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51298
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068421
UK 383367	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.95
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.051
BRD-A09062839_Amyleine hydrochloride_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SMARCA4	ChEA Transcription Factor Targets	1.0	null
BRD-K13566078_BMS-345541_SKBR3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	134.161
hsa-miR-3135b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
T24	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.80977
UE-90-AA63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.370257
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68548958_-666_HA1E_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PCK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0089737
SK-HEP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.116
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
AKT_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57228212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22921
GSE186440,GSE186443_2_v_5_daxx_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-A7UU-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.107995
GTEX-O5YT-1026-SM-3MJGF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0356
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WH7G-0426-SM-3NMBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20644
BRD-K90543092_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K19325444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04045
AC-30-XU83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220062
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71252
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
pattern	GeneRIF Biological Term Annotations	1.0	null
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.460799
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCO2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.73558
ChIP_ASH2L_23239880	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
heart_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.72841
LS-411N	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.39973
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.9769
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
OCUG1	DepMap CRISPR Gene Dependency	1.0	2.52741
PBX3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glufosinate	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
GSE148066,GSE157787_9_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A64849281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02938
HIPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00584017
LB831-BLC	GDSC Cell Line Gene Expression Profiles	1.0	1.43841
acute	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
REST-18959480-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE223893_1_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A47598013_Citalopram hydrobromide_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
organs	GeneRIF Biological Term Annotations	1.0	null
scalp	GeneRIF Biological Term Annotations	1.0	null
reductases	GeneRIF Biological Term Annotations	1.0	null
thp1	HPA Cell Line Gene Expression Profiles	1.0	0.882482
GTEX-WFG8-2226-SM-3GIL9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62168
ZFTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46718
HCC1428	CCLE Cell Line Gene Expression Profiles	1.0	1.38305
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38111331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00737
GTEX-TSE9-0011-R8A-SM-3DB7R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05731
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07145
Phagophore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.001
Lung adenocarcinoma_LUAD_TCGA-50-8460-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HIV-1_LAI_12Hour-UV_treatment_None_GSE56484	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.57451
BRD-K51544265_cabozantinib_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.985949
PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-GATA3_only-Nearest_Ensembl_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
TRPM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00542115
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.690371
KPNRTBM1	CCLE Cell Line Gene Expression Profiles	1.0	1.83997
GSE218727_0_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Plastid stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.743
Mildronate	DeepCoverMOA Drug Mechanisms of Action	1.0	0.21
Raynaud-Claes syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.964793
H3K36me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AGTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067858
dl-alpha tocopherol-1320	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K67702605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02854
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.975927
TFAP2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.066669
BRD-K17140735_-666_MCF7_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PVOW-0126-SM-2XCFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919524
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YN-11A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K18173053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40878
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fetal Death	CTD Gene-Disease Associations	1.0	1.36848
HNF4A	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4114-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
Type III protein secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.181
digestive	GeneRIF Biological Term Annotations	1.0	null
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1666
HS611T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76243
SZ in subgenual cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02463
BRD-K15409150_PENFLURIDOL_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KMS27	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64511
GTEX-XPVG-1326-SM-4B65P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824231
NDUFB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0932
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00158
mantle zone of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48433
BRD-K81888673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22559
DLG4	Hub Proteins Protein-Protein Interactions	1.0	null
HNF4A	ENCODE Transcription Factor Targets	1.0	null
outer CP in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19569
MD-17-VD78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254422
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48415
ZNF384	ENCODE Transcription Factor Targets	1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
GRIK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00488913
S0-EE-YEKU_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223967
MPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4586
JHU022	DepMap CRISPR Gene Dependency	1.0	10.4233
BRD-K08753635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18203
fulvestrant-7096	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K68733377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00737
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.506227
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMCH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565926
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-2.10021
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83633
SAP30	ENCODE Transcription Factor Targets	1.0	null
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
FUT4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00464203
BRD-A26787626_CYCLOPIAZONIC ACID_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00511
BRD-K82362034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31425
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Nearest_Ensembl_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K49865102_PD-0325901_A375_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Multiple carboxylase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
HES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24597
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43986
BRD-A76528577_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
5919_STN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.703269
Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29409
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.976672
perimammillary part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43486
GTEX-WHSB-1326-SM-3LK6W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10851
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
BRD-A60245366_AS-601245_SKBR3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WYJK-0126-SM-3NMAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07214
NFYA-21822215-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K13169950_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q734-1426-SM-48TZQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850653
PTEN_KD_GDS2958_101_human_SKBR-3 MAMMARY ADENOCARCINOMA cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.54552
COX7A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00880804
BRD-K08109215_I-BET_MCF7_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE101546_3_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0519
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3518
FBXL20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608273
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20695
6548_POLR2G_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.522066
VZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.90827
GTEX-P4PQ-0326-SM-2HMJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48653
GSE144115_4_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BD-81-LB65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20961
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE210476_11_v_4_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cob	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.449
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-1.06452
STAMBPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00565513
dlx4_00000000_mcfdash7_gof_human_gpl201_gse21657	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.288442
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09089
1455_CDR2L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.514928
GTEX-OXRL-0726-SM-3NM9A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997811
BRD-K13662825_dinaciclib_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intermediate stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49379
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lytic vacuole	LOCATE Predicted Protein Localization Annotations	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82764092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05665
Macronucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.929
BRD-K87142802_ABT-888 (Veliparib)_THP1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BF-49-KQ10_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302832
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K65417056_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cytoskeletal protein binding	GO Molecular Function Annotations 2015	1.0	null
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.45125
GTEX-RU1J-0526-SM-46MUT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.92433
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30388
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.493
BRD-K00562490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0554
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.15168
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.90284
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57706
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EKVX	GDSC Cell Line Gene Expression Profiles	1.0	1.78993
BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_HA1E_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K94325918_-666_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CACNA1I	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519663
SPRED2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00329175
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A98283014_C3930_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252463
NELFE	ENCODE Transcription Factor Targets	1.0	null
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19894101_MST- 312_A375_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventrolateral part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0039
Epoxomicin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.17
Perturb_7048_KO_Dll4_SRP057171	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.01367
BB-86-UL91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.325438
Thylakoid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.783
PML	ENCODE Transcription Factor Targets	1.0	null
CHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.849954
H3K4me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37151525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25068
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K92571446_WZ-3105_A375_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FAAH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00524535
LM-1685-253	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OIZH-0326-SM-2HMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64689
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.09576
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7111_RARA_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.548385
Carbamazepine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.878615
BRD-K54099984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29502
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41264
Perturb_13928_OE_DLG2_ERP119345	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.2579
SNU520	CCLE Cell Line Gene Expression Profiles	1.0	1.3829
AZD8055	DeepCoverMOA Drug Mechanisms of Action	1.0	0.94
Lung squamous cell carcinoma_LUSC_TCGA-22-0940-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78618254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82165
GTEX-N7MS-0826-SM-2HML4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04255
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cataract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
Lung squamous cell carcinoma_LUSC_TCGA-66-2778-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066511
Electrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.89
BRD-K01888220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49044
Lung adenocarcinoma_LUAD_TCGA-44-3918-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228813
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
MITF	ChEA Transcription Factor Targets	1.0	null
BRD-K44417704_NCGC00182607-01_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
sirolimus-1022	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
most	GeneRIF Biological Term Annotations	1.0	null
GTEX-QEG5-0926-SM-2TC64	GTEx Tissue Sample Gene Expression Profiles	1.0	2.63502
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EWS-ERG-20517297-CADO-ES1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
amygdalohippocampal transition zone, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.869819
GTEX-WH7G-2026-SM-3NMBL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940784
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.028899
BRD-K63169405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50891
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55655
5903_NUP93_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06115
BRD-A68930007_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RWSA-0126-SM-2XCBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07826
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20627
GSE130246_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FA-63-WI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233028
CB-24-AT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.569493
GSE232631_5_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67578145_GDC-0879_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.6742
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TEX101	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563091
GTEX-XGQ4-0526-SM-4AT6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26044
BRD-K46970272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35658
OAW-28	GDSC Cell Line Gene Expression Profiles	-1.0	-1.54482
PIGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00688662
GSE162688_3_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCIH520	CCLE Cell Line Gene Expression Profiles	1.0	1.93688
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF232	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01467
BRD-K38251852_Paxilline_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.61598
ganglion cell layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.257572
Endocardium disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.73
i-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.698
caudal prosubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18792
trimetazidine-1727	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Mild Cognitive Disorder	DisGeNET Gene-Disease Associations	1.0	null
Duvelisib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.5
16872506-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
DDI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03571
NMC-G1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE135352_2_v_3_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17239874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52864
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.0531
BRD-K60460300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99877
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.00551
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05399
LPA2 An1	DeepCoverMOA Drug Mechanisms of Action	1.0	0.72
4955_MED4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08206
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V1D1-2026-SM-3GAF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858076
Pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.595
GSE178907_4_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
9841_WDR75_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.544385
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054288
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	60.3704
Signal peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.955
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	1.0	null
4939_MED17_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31552
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
Acute Myeloid Leukemia_LAML_TCGA-AB-2977-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A02481876_Importazole_MCF7_24.0_h_60.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K00414849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37448
Eye degenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06936
BRD-K72238567_656402-250MG_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TCF7L2_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.936883
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.68878
GABRG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00449122
BRD-K79946769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32277
4953_MED30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.2182
BRD-K73330516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01571
Obesity-related traits	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
actin binding	GO Molecular Function Annotations 2015	1.0	null
PMC11794132-41375_2024_2473_MOESM9_ESM.pdf-10-NFIC_1_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
anterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.899175
BRD-K44975377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34477
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.638224
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S4UY-0126-SM-3K2BB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951606
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.112
JB-23-ZE86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348113
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.08628
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18173
Vegetative stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.512
eye and adnexa disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.218715
GSE92364_0_v_5_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10679
diethylstilbestrol_rattus norvegicus_gpl1355_brown norway_gds2913	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Type 2 diabetes mellitus_Endocrine Pancreas - Islet Cell of Langerhans - Beta Cell (MMHCC)_GSE6428	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.98291
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6940_KO_Rbm20_SRP403612	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.12729
perimammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74711
BRD-K73789395_ZM 336372_HT29_24.0_h_102.71_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE207433_2_v_3_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_16957_KO_Drp1_SRP173900	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.13253
Perturb_5235_KO_Ncor2_SRP222273	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.02391
BRD-K19139070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17101
BRD-K30382953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91629
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
BRD-K93176491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00251
Uterine leiomyoma_Uterus - Myometrium (MMHCC)_GSE593	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.85946
H3K27me3_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K40738845_BMS-777607_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K62957665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12557
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A60245366_AS-601245_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF684	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91936
GTEX-RU72-0326-SM-2TF5T	GTEx Tissue Sample Gene Expression Profiles	1.0	2.19407
BRD-A45889380_QUINACRINE HYDROCHLORIDE_NCIH1836_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.99879
DMRT1-23473982-TESTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72355
NUGC3_STOMACH	CCLE Cell Line Proteomics	1.0	3.1459
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847164
CHD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00519769
BRD-K11853856_PJ 34 hydrochloride_SW620_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
epidermal	GeneRIF Biological Term Annotations	1.0	null
BRD-K19237647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85641
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.96604
layer 6 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52679
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KARPAS-299	COSMIC Cell Line Gene CNV Profiles	1.0	2.59653
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4945_MED22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.921958
Lung squamous cell carcinoma_LUSC_TCGA-33-4566-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Medial lobe of mushroom body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.274
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.941315
Perturb_10621_OE_Mst1_SRP398098	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K65184008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09119
BRD-K12396271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23234
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2109
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.1
Dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10151
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K22957824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62536
NISCH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40065
LY-294002-6195	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GA-16-IU17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.436637
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6225799-annrheumdis-2018-213524supp003.xlsx-Activated-state-LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MPHOSPH6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00468231
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.471234
ALVA31	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.890875
BRD-K54939987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68114
BRD-K13390322_AT-7519_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
S0-EE-Y97N_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334379
HOP92	CCLE Cell Line Gene CNV Profiles	1.0	1.42431
BRD-K07691486_roscovitine_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K35708212_Strophantine octahydrate_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RNOR-1326-SM-48FDE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891674
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-6.17149
ps90	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.694
4150_INTS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50797
HCC70	CCLE Cell Line Gene CNV Profiles	1.0	2.46215
UPCISCC152	DepMap CRISPR Gene Dependency	1.0	3.14365
TAF1	ENCODE Transcription Factor Targets	1.0	null
supramammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.92194
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Toxic shock syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	551.2
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A68930007_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-V1D1-0726-SM-4JBH7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00669
9461_TXN_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.618496
BRD-K82292504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18595
SNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15653
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347267
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A69L-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fruit capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.89
ADORA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664851
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral (parvicellular) part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22834
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04785
BRD-K07836769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28072
medial parabrachial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00081
PMC12816669-41698_2025_1236_MOESM1_ESM.pdf-968-SREBF2_SREBF2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31337291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1612
BRD-K78126613_MENADIONE_WSUDLCL2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Primary somatosensory area, lower limb, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00224
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.30156
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
5587_NEDD8-MDP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.06019
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4181
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35939
peduncular part of dorsomedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68461
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.924145
zinc sulfate_rattus norvegicus_gpl341_gds3369	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.282857
intermedioposterior nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04536
BRD-K53088255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00388
BRD-K88510285_B675700.cdx_PL21_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.1166
clozapine-1170	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06942
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41929
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MKN74	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53261
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67748
BRD-K03304013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47593
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mediodorsal nucleus of the thalamus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.167
GTEX-WI4N-0626-SM-3TW8Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85674
SARS-CoV MA15_Day2_None_GSE49263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.74014
Perturb_6313_OE_GLDN_SRP407749	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.76851
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19442
single-organism process	GO Biological Process Annotations 2015	1.0	null
Ebolavirus(ZEBOV)_1day_Spleen_None_GSE57214	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.50042
CD8+_Tcells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.29807
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K33551950_R2146_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC4006	CCLE Cell Line Gene CNV Profiles	-1.0	-2.32525
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37392901_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18425
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12079898_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69348
GTEX-VJYA-0826-SM-4KL1M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07336
BACH1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-641	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64767126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20624
BRD-K94325918_-666_RMGI_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE188458_2_v_3_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE225762_1_v_0_pcmt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53172
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A3UC-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE247862,GSE247863_0_v_3_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ion binding	GO Molecular Function Annotations 2015	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AM-095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27604
BRD-K23867157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64549
Vaginal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.661
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4422
BRD-K05877335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48897
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33442
Jurkat	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.35696
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1176
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36968
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64103
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BRD-A41450521_Tosufloxacin hydrochloride_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A38030642_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K12003101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34773
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00449
ChIP_REST_18959480	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5100-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19331
hsa-miR-3064-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
FADS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63231
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27366
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45456
DPF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495786
Middle lamella	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.62
OPRL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00758479
lymphnode_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.09412
carnitine-acylcarnitine translocase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
GTEX-Q734-0826-SM-48U1G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827849
BRD-K97263385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42369
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.888725
BRD-K18142082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24491
MMP10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00632923
569_ASB8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544536
YME1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0126264
Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U-698-M	GDSC Cell Line Gene Expression Profiles	-1.0	-2.12887
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31559
BRD-K49865102_PD-0325901_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3611	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE114284_2_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134896_0_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2179
capan2	HPA Cell Line Gene Expression Profiles	1.0	0.847977
BRD-K05753543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37595
ADCY5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00589054
H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25711
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y7-01A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92484282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54584
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10718
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
uterus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
BRD-K92428232_GSK-461364_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MM160113	DepMap CRISPR Gene Dependency	1.0	3.35069
A-VN-1203-2004(H5N1)_Day1-10^3pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.51516
Lung adenocarcinoma_LUAD_TCGA-50-6597-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ED-27-OE11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230468
GB-64-HC34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.362575
GTEX-QLQW-0626-SM-447A6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00512
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CE-18-ZM38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.458593
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.704
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00985
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Fetal Brain Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.44856
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.940726
BRD-K88378636_withaferin-a_HS578T_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Olvance	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
BRD-K79228133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26174
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05514
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PRX-08066	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KCNK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00597976
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21384
BRD-K85402309_dovitinib_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
regulation of nucleic acid-templated transcription	GO Biological Process Annotations 2015	1.0	null
ISL1-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Bone_Marrow-cd24 neutrophil	Tabula Sapiens Gene-Cell Associations	1.0	-0.189685
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.248361
HUO9	DepMap CRISPR Gene Dependency	1.0	3.0973
GTEX-XPT6-0126-SM-4B65S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69737
while	GeneRIF Biological Term Annotations	1.0	null
CPT1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00778461
Perturb_6495_KD_PIEZO1_SRP392492	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K27ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cytosol	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.472011
GSE159678_4_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.11402
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91628074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10942
BRD-K05605336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.90685
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.3195
Bergenin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.47
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HUS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564657
Choroid plexus epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.665
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Wolff-Parkinson-White syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
BRD-K31348453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00483
SPTLC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554041
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.6283
NCI-H2110	COSMIC Cell Line Gene CNV Profiles	1.0	2.59653
GTEX-WYJK-1126-SM-3NM9Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920375
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
dorsal part of JcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.1162
CHD2	ENCODE Transcription Factor Targets	1.0	null
preoptic region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17722
CHD1-26751641-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Diisocyanate-induced asthma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
liver	GeneRIF Biological Term Annotations	1.0	null
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.94401
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
Lens disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
GSE201042_6_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14399036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16578
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.052
BRD-K38997615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21612
Protein storage vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.826
lung fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.325701
carisoprodol-1314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K22475995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91514
CC-03-PW00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.850439
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00718646
8816_TELO2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.54297
JUND	ENCODE Transcription Factor Targets	1.0	null
BRD-K14117311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40348
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.957696
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04788
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
reductant	GeneRIF Biological Term Annotations	1.0	null
LTB4R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482119
496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.51916
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JM1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.08325
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03674
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Cystic fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.326
MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.3141
CAKI1	DepMap CRISPR Gene Dependency	1.0	2.28526
BRD-K02992638_lamivudine_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mantle zone of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20801
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K12343256_trametinib_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6181_PDIA6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.602798
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BF-97-LS55_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358851
GSE216147_2_v_3_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MG-132	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.2
basal nucleus of Meynert	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.93712
BRD-K19216856_(-)-Gallocatechin gallate_SKMEL28_6.0_h_88.8_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K92928918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65973
well	GeneRIF Biological Term Annotations	1.0	null
RXR-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K15930345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12095
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PIM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00519037
finasteride-2206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K90382497_-666_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PKDCC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537873
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.37392
FGF14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00538275
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.5502
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89039
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SETDB1	ENCODE Transcription Factor Targets	1.0	null
glutamate-cysteine ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.795
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.01474
MCF7_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0131073
BRD-A19633847_PERHEXILINE MALEATE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K73669270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54151
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A6HP-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATPase dependent transmembrane transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.224
HNF4G	ENCODE Transcription Factor Targets	1.0	null
BRD-A15079084_phorbol-12-myristate-13-acetate (PMA)_SNGM_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K56001384_A8674_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21081
Seratrodast	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
Perturb_572_KO_Plod1_SRP321648	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.04334
GSE168596_1_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
496100573_HIP_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24368
metal ion binding	GO Molecular Function Annotations 2015	1.0	null
testis_7d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.38235
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13328
GF-35-IT27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27086
BE-17-CS60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209583
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.51531
AZD7762	DeepCoverMOA Drug Mechanisms of Action	1.0	1.04
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12938
4941_MED19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.671782
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.890383
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37746
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
BRD-K13265046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08838
GSE114258_3_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GHDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22863
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE148066,GSE157787_11_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.474547
Brain microvascular endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.214
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.19843
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K31602570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08243
layer 1 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08312
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.849869
BRD-K72488042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63156
BRD-K35035851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57664
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.003
BRD-K34602185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02336
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Tipifarnib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.58
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K24549321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21012
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.475159
BRD-K49865102_PD-0325901_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51577368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10502
BRD-K68143200_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GSE210101,GSE210114_11_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253193
Perturb_1789_KO_Irf8_SRP265303	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.39064
WM1799_SKIN	CCLE Cell Line Proteomics	1.0	3.12419
BRD-K06592610_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
medial (magnocellular) part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17951
NCIH2452	CCLE Cell Line Gene CNV Profiles	1.0	2.00889
Nervous System Malformations	CTD Gene-Disease Associations	1.0	1.05793
EGR1	ENCODE Transcription Factor Targets	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
16651414-Supp2	GeneSigDB Published Gene Signatures	1.0	null
MARS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00725592
CRCGN014_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38554
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K50660797_EPICATECHIN MONOGALLATE_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K20183527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66889
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A19500257_geldanamycin_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cerebellar cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.829771
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1YY-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lens epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.408592
parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.056206
HOXC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00739
BRD-K03659510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08487
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4839-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1437	CCLE Cell Line Gene CNV Profiles	1.0	1.39452
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.28665
Histone locus body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.772
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Midline group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02216
ATAD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00470246
BRD-K19085288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52865
GTEX-NPJ8-0426-SM-2HMK6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9658
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Nearest_Ensembl_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
MOR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33165
Anteroventral nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.669
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.22046
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.86363
SPTA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00854458
PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54576503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56132
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE155567_1_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
resolving	GeneRIF Biological Term Annotations	1.0	null
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.7515
BRD-K78126613_MENADIONE_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WY7C-0526-SM-3NB3D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05536
BRD-A20697603_598226_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ChIP_ZFP281_18358816	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE144838_4_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K03736784_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Dicyclohexylamine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.52
kidney	GeneRIF Biological Term Annotations	1.0	null
GTEX-XPVG-2126-SM-4B667	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.837061
actin filament polymerization	GO Biological Process Annotations 2025	1.0	null
dorsomedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.829501
BRD-K77808555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.45689
IDI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549227
2858_FAM136A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.736038
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Stomodeum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.504
Stem nodule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.31
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31011
BRD-A77577770_AC-1121_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4769-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
QE-00-EB96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286922
PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
actin binding	GO Molecular Function Annotations 2023	1.0	null
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03892
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00624019
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.419
496100621_TCx_probable Alzheimer's disease_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03538
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16517
BRD-K18573205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20878
lymphnode_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.939554
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201042_6_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
smallintestine	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.86087
PPP2R5A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571611
GSE223008_7_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3179	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
shafts	GeneRIF Biological Term Annotations	1.0	null
RP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00482021
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	2.53013
KYO1	CCLE Cell Line Gene CNV Profiles	1.0	1.33496
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30025
CMLT1	DepMap CRISPR Gene Dependency	1.0	2.90826
Silique	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
parasitic helminthiasis infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.374438
GSE225218_9_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.6816
shell of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72888
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VUSG-2326-SM-4KL1U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883614
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.5239
SCARA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00841845
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36812
Endocarditis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.739
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19O-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.61753
Hemorrhage	CTD Gene-Disease Associations	1.0	1.22664
Cus cation efflux complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.923
BRD-K61517058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99369
NFE2L2_Mutation_GDS4498_597_mouse_Skin	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CCL4L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00599919
NCIH2887	DepMap CRISPR Gene Dependency	1.0	2.82876
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232557
BRD-A10715913_SULPIRIDE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P4QT-0126-SM-2I3FL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69008
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
BRD-A25736793_everolimus_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A-375	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.828982
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15119
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
valproic acid_mus musculus_gpl6885_gse41020	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nucleus	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0808
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53716
Subcortical maternal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.617
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Symbiosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.707
gemfibrozil-1430	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DMS-53	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.56607
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AICD_Induced  expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE200673,GSE200691_2_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K99127896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23055
HNF4G_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149075_6_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZFX	ChEA Transcription Factor Targets	1.0	null
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
BRD-K15992638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97781
Sepsis_Splenocyte_GSE4479	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.41061
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21486
r4 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2439
retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.315366
GSE149903_0_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4944_MED21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.922732
DE-28-XP50_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21507
3050_FDPS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.636531
HNF4A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K62841603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01289
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A45498368_WYE-125132_HME1_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299666
HA-22-CY42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209851
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
SUDHL6	CCLE Cell Line Gene Expression Profiles	-1.0	-1.77675
DU4475	CCLE Cell Line Gene Expression Profiles	1.0	2.45338
GTEX-QDVN-0926-SM-2I5GL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961893
age related macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.793771
stratum spinosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.234878
BRD-K83988098_S1142_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.012
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.282
mecamylamine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49993
Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04623885_BIBR1532_RMGI_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.947634
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein polymerization	GO Biological Process Annotations 2025	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5001-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K00313977_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.40044
Periplasmic space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.927
trifluoperazine-6183	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A39093044_K784-3187_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cognitive trait	GAD Gene-Disease Associations	1.0	null
sodium-phenylacetate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26792
BRD-K86104966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55968
BRD-A38275906_ST019366_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K21025364_NVP-TAE226_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BF-01B-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Field CA2, stratum pyramidale	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15671
AKAP17A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18835
Dorsal premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.77711
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A41B-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NFKBID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02769
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5296
Alzheimer Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21531
Bag cell neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.51
medial geniculate nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34878
Septofimbrial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59598
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Dorsomedial nucleus of the hypothalamus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76608
NCIH522	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41604
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.743805
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211024
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
hsa-miR-150	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K37803976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73316
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.2595
BRD-K93123848_RAF 265_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
4932_MED12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.27203
BRD-K31197843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03552
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_24_human_DRSG_higherRes-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04307
hair follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.251606
amygdaloid complex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.922588
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE218727_0_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04388
BRD-K36740062_GSK-1070916_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
methionine-importing ABC transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.094
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	69.3067
TAL1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3667-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Succinate dehydrogenase complex (ubiquinone)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.797
GTEX-WHPG-1026-SM-3NMBA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18249
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-4.10739
BRD-A19500257_geldanamycin_MCF7_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.664
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83689
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149075_6_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ventral premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.09303
BRD-K39140255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24443
BRD-K41707108_C2 CERAMIDE_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K89366873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98786
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36201
BRD-K30071505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23077
GA-28-SS67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.731622
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	1.0	3.46472
KDM4A	ENCODE Transcription Factor Targets	1.0	null
MED13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00441896
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE188870,GSE188871_0_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05087
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.6427
DC-84-GJ21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.975675
rpmi8226	HPA Cell Line Gene Expression Profiles	-1.0	-1.22015
FAM47E-STBD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558978
Acute Myeloid Leukemia_LAML_TCGA-AB-2981-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC5A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00662826
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3155
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114284_2_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AHCY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558599
Tail	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.641
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.95395
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K19499941_2-Chloro-N-heptyl-N-m-tolyl-acetamide_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134896_0_v_7_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Biotinidase deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.112
STAT1-20625510-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRF2-31884422-A549-HUMAN-LUNG-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
buildup	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X5EB-1926-SM-4E3IW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00961
GSE220520_3_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
primary auditory cortex (core)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.858512
periventricular stratum of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09364
GTEX-T6MN-0926-SM-32PLX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.95743
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041626
NCIH2106	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64304
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04154
GATA3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
granular layer of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.917969
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cpa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
upper basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33348
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05531
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.477974
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1799
BRD-K80396088_Gliquidone_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
diethylstilbestrol_mus musculus_gpl6887_gse37969	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SS-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11799530-12276_2024_1380_MOESM1_ESM.xlsx-DEG_KD_PC-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SQ1	CCLE Cell Line Gene CNV Profiles	1.0	1.91324
GTEX-XPVG-0726-SM-4B658	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50822
RC-K8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13714
BRD-K21819164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18582
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0126-SM-32PLP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900034
external segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3017
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03402
Merocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.58
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
BRD-K67783091_HALOPERIDOL_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
INSM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.4167
tc90	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.789
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91285
GTEX-QLQ7-0526-SM-2I5G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34352
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE110341_1_v_0_lmna_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
16166195-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_1day-MOI-10^3_None_GSE43302	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-3.45811
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	1.0	null
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.32399
exocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.106815
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00231
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235644_1_v_0_fasn_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.013
BRD-K89637567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23374
CEBPD_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.9832
BRD-A72703248_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.028192
BRD-K24132293_piperlongumine (HPLC)_COV644_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K79090631_CGP-60474_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32071534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88942
Dorsomedial nucleus of the hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5951
hsa-miR-3132	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K82823804_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mediodorsal nucleus of the thalamus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25086
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K48059230_YM 298198, Desmethyl-_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE238005_5_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Human brain microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.219
GTEX-NFK9-0226-SM-2HMKQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08253
GTEX-T8EM-1026-SM-3DB7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14264
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.5322
macromolecular complex subunit organization	GO Biological Process Annotations 2015	1.0	null
Taranabant	DeepCoverMOA Drug Mechanisms of Action	1.0	0.51
REST-19997604-NEURONS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WHPG-0826-SM-3NMBF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41438
BRD-K81418486_vorinostat_SKM1_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOS_MCF 10A_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378652
PMC10830421-41589_2023_1452_MOESM5_ESM.xlsx-HEK293T_MAX-Tg_tissues-Unnamed_0_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
PLB985	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40253
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A11095214_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WFJO-0626-SM-4LVMC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07359
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral parabrachial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.868678
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052665
19286929-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
Bed nucleus of the anterior commissure	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.39207
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16432886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37807
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.109
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100445_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05565
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FAHD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29577
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A74904029_EI-231_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-5847-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-WQUQ-1326-SM-3MJFF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20091
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A9-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64890080_BI-2536_LNCAP_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XQ3S-1226-SM-4BOPP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03802
GAS6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00675733
basal peduncular hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15298
BRD-K31210612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97206
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21832
BRD-K61323504_sb 225002_VCAP_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619877
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054176
BRD-K48463604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59915
superficial stratum of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50719
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K52735829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17887
GSE153189_1_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39V-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE196117_1_v_11_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.82879
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mastitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.506
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3617	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GTEX-Q2AH-0526-SM-2I3ED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30769
GSE223008_4_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K99416393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0984
GSE175883_0_v_1_dis3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-MB-A5Y9-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE48812_8_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
acts	GeneRIF Biological Term Annotations	1.0	null
proxymetacaine-3113	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZB-16-BR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.647406
BRD-K53798768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03581
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K75073374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0456
BRD-K08618283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19743
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A182-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.115
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Electric organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.788
mediodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2768
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.22599
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26172
PMC9810535-41590_2022_1370_MOESM3_ESM.xlsx-Table_S2-Table_S2-MECOM_network_genes_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
Urogenital Abnormalities	CTD Gene-Disease Associations	1.0	1.21337
GTEX-WQUQ-0426-SM-3MJFU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873317
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
CPCN	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57556
upper basal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34083
GTEX-U8T8-0126-SM-3DB94	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17182
hsa-miR-4775	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
19235837-TableS2a	GeneSigDB Published Gene Signatures	1.0	null
HCC70	GDSC Cell Line Gene Expression Profiles	1.0	1.92307
BRD-K81473043_-666_PL21_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K05335635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30538
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
Perturb_3537_KD_HNRNPK_SRP355083	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.9642
TAGAP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0059018
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60030763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34071
BRD-K27754030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87942
GSE214823,GSE214824_6_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926706
H3K36me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMMY-0226-SM-33HBA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894297
GTEX-X261-0126-SM-3NMD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936799
Zotarolimus	DeepCoverMOA Drug Mechanisms of Action	1.0	0.56
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.21759
SIN3A	ENCODE Transcription Factor Targets	1.0	null
BRD-K07313741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34152
BRD-K92725027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3888
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44895
15489324-TableS2	GeneSigDB Published Gene Signatures	1.0	null
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ERBB2_knockdown_237_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.78904
AA92593	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.88
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.6712
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.73228
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15269548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44251
DMRT1	ChEA Transcription Factor Targets	1.0	null
STAT1	ChEA Transcription Factor Targets	1.0	null
Placenta Diseases	CTD Gene-Disease Associations	1.0	1.02003
SH10TC	CCLE Cell Line Gene CNV Profiles	1.0	1.45749
TCFCP2L1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19961
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70076
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.994048
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K03063480_PF-477736_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.603732
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LC-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70412
RYR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502195
H4K20me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Eisosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.993
GSTA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621298
thereby	GeneRIF Biological Term Annotations	1.0	null
5427_NAA25_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.534412
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.99902
H2AC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12648
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.26439
intermediate stratum of PHyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71936
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGFR_druginhibition_83_GSE27640	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.22539
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7499_RPS11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00137
PSMB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00619109
BRD-K37865504_LY-2183240_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Aerial part	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.844
GSE165548_2_v_13_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.810414
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74148702_curcumin_HA1E_24.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35339
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49865102_PD-0325901_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tanespimycin-6177	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPS6KA3_knockout_73_GSE22137	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.81519
PMC7603494-41467_2020_19353_MOESM6_ESM.xlsx-Ch_TCF3_up_and_binding_Overlapp-Unnamed_6_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38678
GLIS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16791
BRD-A93236127_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BHMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1535
CD4_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.31043
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H524	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4659a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DCLK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005894
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QS-2026-SM-3NMCG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32484
Sulindac metabolic pathway	WikiPathways Pathways 2024	1.0	null
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.123007
GSE150215_1_v_2_etl4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AV-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tripartite attachment complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.847
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.79189
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K73830970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45372
BRD-K52075040_-666_SKM1_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K51608228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09146
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A57353172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28754
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.553683
NTERA2CLD1	DepMap CRISPR Gene Dependency	1.0	6.3107
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04438
hsa-miR-921	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
HDAC1	ENCODE Transcription Factor Targets	1.0	null
Bacterial meningitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
GTEX-WHSE-0126-SM-3NMBT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2393
HDAC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00576977
SNU1544	DepMap CRISPR Gene Dependency	1.0	5.33456
skin	HPA Tissue Protein Expression Profiles	-1.0	-0.81014
GTEX-OHPL-1026-SM-3MJGI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66075
callosal sling	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.861122
CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
intermediate stratum of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4142
GSK3A_KD_GDS4305_184_human_U937 acute myeloid leukemia cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K62325456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3427
BRD-A79768653_sirolimus_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HTR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50821
BRD-K03057797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18333
TFCP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7572
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
GSE198165,GSE198166_9_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.953991
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Storage vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.798
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OMC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.55926
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	176.229
STK235555	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
WDR87	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00720821
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04
PLSCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0044601
GTEX-X4EO-0326-SM-3P5YO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869558
layer VI of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07282
ventromedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.945326
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02822062_CT-200783_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pirenzepine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.91
AE-19-BK71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.4316
MAFK	ENCODE Transcription Factor Targets	1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Increased_in_both_CSDE1_KD_hESC-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Chloride channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.361
TNFSF13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487088
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16909
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.581559
HOXB4	ChEA Transcription Factor Targets	1.0	null
8272_SON_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509488
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11636
RUNX1T1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051565
GTEX-WEY5-0226-SM-3GIKN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20323
IP6K1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00702685
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.3162
PMC7388612-vdaa078_suppl_supplementary_table_6.xlsx-MRs_PN_Rim-vs-MRs_PN_C-MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE123825_1_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4b-WT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28375929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02493
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.60366
Ribociclib	DeepCoverMOA Drug Mechanisms of Action	1.0	0.7
8433_SRSF3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.739871
Lung adenocarcinoma_LUAD_TCGA-78-7149-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.418493
BRD-K14442101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04142
Cervical epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.024
EC-GI-10	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.13498
HCT 116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.880877
GSE157296,GSE157298_4_v_5_kbtbd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052374
9215_TPR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.795784
anterior nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78758
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K09951645_dabrafenib_A375_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE214583,GSE214585_1_v_0_steap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP2	ENCODE Transcription Factor Targets	1.0	null
BRD-K85168571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15893
HS742T	CCLE Cell Line Gene Expression Profiles	1.0	1.6139
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.262986
DF-00-BU08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238183
anteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37141
central lateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01179
BRD-K01660763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14407
PAX5	ENCODE Transcription Factor Targets	1.0	null
GSE162739_4_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.862454
GSE164757,GSE164759_1_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K60623809_SU11652_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE162892_3_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68548958_-666_A549_24.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Ethanolamine ammonia-lyase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.313
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.68165
BRD-K60230970_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.891897
BMI1_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-WY-A85A-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.932399
CCT128930	DeepCoverMOA Drug Mechanisms of Action	1.0	0.75
disease	GWASdb SNP-Disease Associations	1.0	0.025083
NCBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0104159
Adrenocortical carcinoma_ACC_TCGA-OR-A5L3-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
SUDHL5	CCLE Cell Line Gene Expression Profiles	-1.0	-2.01529
MRPS33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48374
GTEX-P4QS-0726-SM-3NMCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976077
BRD-A19037878_trichostatin A_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TAL1-30185409-K562-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
SK-MEL-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01194
BRD-K24132293_piperlongumine (HPLC)_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-424	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.33073
schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.165001
TUBB6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00365034
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845863
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60230970_MG-132_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.347
BRD-K44141416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10811
THAP1	ENCODE Transcription Factor Targets	1.0	null
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00315
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAT protein transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.686
8155_SMC1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.850033
GTEX-PX3G-0726-SM-48TZT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838078
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05622
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Meningitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.621
HIF1AN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00757371
Fungal biofilm matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.129
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5428
ACADSB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00657612
OR10S1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00725463
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hair	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.103338
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054289
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.33104
Mediodorsal nucleus of the thalamus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40487
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55342
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04811
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kinetoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.698
ATP1B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40497
urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.071984
H3K27me3_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FB-98-HM88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206254
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1852
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular stratum of r4Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2439
BRD-K76420749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86716
ATP5PB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00511962
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30999
BRD-K28168037_Fenretinide_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
non-syndromic X-linked intellectual disability 92	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60056
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
CHK2_KD_GSE54268_668_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K53281329_SYK-inhibitor_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974271
W chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.58
Paraventricular nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.89315
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-1.06452
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71252
BRD-K68869896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47181
AE-88-WQ63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220882
DC-43-KF54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318004
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.09471
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5185-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K22384464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05586
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A80502530_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WI4N-0726-SM-3TW93	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3042
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NOP10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00683526
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Gene_Name_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K09951645_dabrafenib_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K78007953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21058
15220918-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
9682_UTP15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.516989
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.513601
7556_RRM1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.607625
PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6642071__F1	PFOCR Pathway Figure Associations 2023	1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K88510285_B675700.cdx_HA1E_24.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2803-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JW-0326-SM-4DM6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35002
E4F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08834
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K21648400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25351
Hydroxyisourate hydrolase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.678
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
19797726-SuppTable1b	GeneSigDB Published Gene Signatures	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
THAP1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_5_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CSNK2A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0797
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1385	CCLE Cell Line Gene Expression Profiles	1.0	1.5094
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.1772
hsa-miR-3162-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
HCC1500	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.95249
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.838972
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04577
2858_FAM136A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.846272
KCND2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0079963
MIR140_Silencing_GDS3462_574_mouse_C3H10T1/2 fibroblast cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
lymphoblastoid cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.373118
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.828558
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SOX9-24532713-HFSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49289
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72543
GTEX-UPJH-0226-SM-3GADV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917175
GTEX-NPJ7-2926-SM-3MJGQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06158
LOVO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Presubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19862
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.532943
DNTTIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43178
striatum_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48864
BRD-K53387776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13673
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.454418
Pericycle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.205
GTEX-V955-0326-SM-4JBGV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25695
NRTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34529
NANOG-16518401-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K64132098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87314
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.73833
GTEX-XOT4-1126-SM-4B66E	GTEx Tissue Sample Gene Expression Profiles	1.0	2.451
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3197
4716_LUC7L3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.575034
BRD-K30566330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83157
ALDH9A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54579
layer 6 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15794
BRD-K24132293_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cellular macromolecular complex assembly	GO Biological Process Annotations 2015	1.0	null
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.613835
nitrofural-6721	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.72636
Perturb_2892_KO_Crls1_SRP132399	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86688
Acute Myeloid Leukemia_LAML_TCGA-AB-2908-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11828
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EDEM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06439
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98582
AR-21915096-LNCAP-1F5-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03509
lower dorsal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12832
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A49046702_SKF 89976A hydrochloride_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.53223
BRD-K04680784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2509
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.48023
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8586238-41467_2021_26788_MOESM6_ESM.xlsx-S2A_CDE_genes-S2A_CDE_-_genes_of_the_two_CCD_genes_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A77440546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14732
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.2634
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.964359
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04571
SUGT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00694538
imatinib_homo sapiens_gpl96_gds3048	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ESC_J1_UP_LATE.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
different	GeneRIF Biological Term Annotations	1.0	null
aging	GeneRIF Biological Term Annotations	1.0	null
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03442
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5682285-41467_2017_1744_MOESM8_ESM.xlsx-Change_in_both_CSDE1_KD_hESCs-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
lateral hypothalamic area, mammillary region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.899569
Schistosomulum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.938
CCK81	DepMap CRISPR Gene Dependency	1.0	4.75293
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.697664
GSE168807_2_v_8_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.845151
MCF7_MC1568_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111315
BRD-K47410882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39883
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
TK-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0266
CHEMBL1597046	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
BB-83-ZM06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.506692
GSE183335,GSE183351_3_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
salivary gland	HPA Tissue Protein Expression Profiles	-1.0	-1.06452
PC-68-DU31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.368393
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.31038
BRD-K40887375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68245
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4b-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0493
BRD-K68530167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39947
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.28408
PBX3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dorsomedial nucleus of the hypothalamus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37949
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-DX-A3M2-01A-21R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4737
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.529418
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
19621087-Table1b	GeneSigDB Published Gene Signatures	1.0	null
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.58992
GPER1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522369
HBA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00526001
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043671
BRD-K12184916_-666_SNGM_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A02799884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38093
PMC11003700-pbio.3002240.s013.xlsx-siMYCN_RNA_IMR32_48h_q_0_05_1_5-Table_S6_Genes_commonly_and_differentially_regulated_by_MYCN_and_WDR5_in_IMR32_cells_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
geldanamycin-2688	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mRNA_ZSCAN4C_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
Type II protein secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.214
sulfoxide	GeneRIF Biological Term Annotations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fat body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.565631
BRD-K28785305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47911
ZNF367	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633097
3861_HNRNPC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506738
10074-G5	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
HDAC2	ENCODE Transcription Factor Targets	1.0	null
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.207643
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
D-407 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.306
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01194
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K64642496_-666_NCIH1836_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K61087440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84931
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.48755
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
TM31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59596
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein repair	GO Biological Process Annotations 2015	1.0	null
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SHISA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0069705
Lung adenocarcinoma_LUAD_TCGA-49-4510-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A13082766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29944
Chloroplast stroma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.663
GTEX-WXYG-2326-SM-4E3I6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934137
BRD-K17315445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26155
Muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71088
BRD-K49865102_PD-0325901_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE203158_12_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AP2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29109
rhein	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42132
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09629
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE195513_0_v_3_cpeb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ChIP_ZFX_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A30758703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35326
968_C12ORF60_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.685127
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Cell tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.001
lateral tuberal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.852498
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-10q22_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
SLC22A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00600032
mitochondrion	GO Cellular Component Annotations 2015	1.0	null
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9284
arcuate nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.3882
BRD-K42873980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58545
BRD-K77947974_Fluspirilen_SKMEL28_6.0_h_4.21_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.3
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.16674
SMAD1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PELO	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00678725
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6292_PHF6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.564979
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ENY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65098
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	209.174
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Field CA2, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03265
WAY 316606	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
RC-18-AD40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202067
PGC-1alpha_Deficiency_GDS4904_310_mouse_Aged gastrocnemius muscle - 10 weeks	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
oxidation-reduction process	GO Biological Process Annotations 2015	1.0	null
BRD-K88510285_B675700.cdx_SW620_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H1770	GDSC Cell Line Gene Expression Profiles	-1.0	-1.59831
HCC70	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.43357
showed	GeneRIF Biological Term Annotations	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.99091
2750_ETF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.699501
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.06815
L-Methionine	HMDB Metabolites of Enzymes	1.0	null
BRD-A75409952_wortmannin_SW480_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37764012_PF-3758309_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
7,8-Dihydroxyflavone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
hsa-miR-621	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
epidermal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063481
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COLO-792	GDSC Cell Line Gene Expression Profiles	1.0	1.46228
Lung squamous cell carcinoma_LUSC_TCGA-O2-A52W-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NDUFV1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00626126
HCC70	CCLE Cell Line Gene Expression Profiles	1.0	1.8661
GSE86021_0_v_1_crenolanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GPNMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00698139
BRD-K73789395_ZM 336372_MCF7_6.0_h_102.71_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535788
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
testis_7a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.14291
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202306
BRD-K12955049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38726
GTEX-QVUS-0011-R6A-SM-3GACX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14164
CRCGN015_MCF10A.TP53.M_24H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5208
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Brain endothelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.182
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K84709232_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TBL1X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12382
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74402642_Chemistry 2804_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K56301217_A112550.cdx_PL21_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0864
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.187
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K89329876_-666_HA1E_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE149903_6_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bartter disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46F-01A-31R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Myotonia congenita	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.965
CDX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33431
inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37937
SZT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00578132
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POU5F1	ChEA Transcription Factor Targets	1.0	null
Dimethylfraxetin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.44
BRD-K28397270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4272
BRD-K29178949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07484
GTEX-PSDG-0926-SM-2I5FP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6217
BRD-K07813434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07656
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	1.44422
NEDD8	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	1.0	0.947768
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00258
GTEX-WFON-1926-SM-3LK7L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993274
GSE162892_3_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TICAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00399028
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
actin filament organization	GO Biological Process Annotations 2015	1.0	null
GSE167886_2_v_1_chd7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GB-57-XV52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.252926
Sarcoma_SARC_TCGA-DX-A3UB-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61002
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.501645
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05242
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23206
BRD-K96799727_-666_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Psoas major	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.711
BRD-K64857848_XMD-885_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K03287885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.71525
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67219
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
184B5	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.902131
L-6 myoblast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.5886
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K68836091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04047
reactive	GeneRIF Biological Term Annotations	1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80607
GTEX-V1D1-0626-SM-4JBHN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2088
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.77417
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19602
HS578T	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.895136
SMAD3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K88510285_B675700.cdx_RMGI_6.0_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2720-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K01716842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22901
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.261
L-Methionine	DrugBank Drug Targets	1.0	null
GTEX-R55E-0826-SM-2TC5M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889755
pedunculo(pontine) tegmental  nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17825
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K74056311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78
NANOG-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XQ8I-1826-SM-4BOOJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46764
plant-type vacuole membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.629
Ramos-2G6-4C10	GDSC Cell Line Gene Expression Profiles	-1.0	-3.21541
BRD-K79090631_CGP-60474_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ependymocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.533065
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85I-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4939_MED17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.945123
fusiform gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.895051
BRD-K43389698_BMS-387032_HS578T_3_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSDMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00486203
basomedial nucleus (accessory basal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.911544
BNIPL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555239
Jalili syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.525
Poisoning	CTD Gene-Disease Associations	1.0	1.11775
PRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554095
CCL24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00479639
BRD-A75517195_thiazolopyrimidine_HA1E_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.848475
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.17958
NCI-H196	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.08707
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RV16_0Hour-B2B_None_GSE28904	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.69475
CHD7	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6972-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216101
ID-12-NA84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21471
ES-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02046
BRD-K56653679_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18103
BICD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25064
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836321
GAD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00480991
GSE164529_0_v_2_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Glutaric acidemia I	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
NCIH196	CCLE Cell Line Gene Expression Profiles	1.0	2.07009
BRD-K72895815_SSR 69071_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
chlorpromazine-1158	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05315
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.401304
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.925615
GTEX-S32W-2126-SM-2XCB1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41079
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917795
GSE216147_0_v_3_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.961065
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22634
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0088
GTEX-XYKS-0226-SM-4BRW3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46999
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293898
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.25963
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.20424
PMC4595011-pgen.1005555.s001.xlsx-MITF_UP-regulated-Gene_name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.833795
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0182
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WRHK-1426-SM-3MJF9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961185
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
sequence-specific dna binding transcription factor activity	GO Molecular Function Annotations 2015	1.0	null
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.890333
BRD-K06926592_Isotretinoin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
vorinostat_homo sapiens_gpl6947_gse41504	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A41250203_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCC5	DepMap CRISPR Gene Dependency	1.0	6.82048
BRD-K54233340_Dorsomorphin dihydrochloride_HCC15_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K02671211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75993
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.33874
MKRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18101
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223782
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GOT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00667539
GTEX-QDVJ-1126-SM-48U1U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976575
YC-57-OY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204309
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PPARA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00677259
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
Copper ion transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.922
GTEX-U4B1-0726-SM-4DXUA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70631
JE-55-OJ53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222263
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
DUSP11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506742
Perturb_234_KD_MITF_SRP048577	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.2438
16289389-TableS1	GeneSigDB Published Gene Signatures	1.0	null
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11828
CRCGN015_HEPG2_48H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01785
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.619
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11864
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251856
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.52557
BRD-K31912990_CGP 71683 hydrochloride_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K39664334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12071
cervix, uterine	HPA Tissue Protein Expression Profiles	-1.0	-1.06452
BRD-K17854062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41463
BRD-K54233340_Dorsomorphin dihydrochloride_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE149123,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
principal sensory nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44985
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.826418
HT1080	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.36691
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.49
anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.958436
BRD-K18194590_MEPHENTERMINE SULFATE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pellicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.558
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3898
BRD-K64052750_gefitinib_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F4-06A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05804044_AZ-628_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
t-lymphoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.525955
SMIM30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71257
BRD-K51313569_palbociclib_BT20_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
retinal pigment epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.584823
tanespimycin-221	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
9175_TOP2A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.37573
TALL1	CCLE Cell Line Gene Expression Profiles	1.0	1.35703
Lateral root primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.808
BRD-K15940717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13454
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.785683
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873215
RPS6KA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0063433
eccrine sweat gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.745864
Lung adenocarcinoma_LUAD_TCGA-49-4486-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
affected	GeneRIF Biological Term Annotations	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.413
BRD-K59041191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47385
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.37813
actin polymerization or depolymerization	GO Biological Process Annotations 2025	1.0	null
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.64703
scavenging	GeneRIF Biological Term Annotations	1.0	null
CRCGN012_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50826
BRD-K24554824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03977
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14470344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1772
CCDC163	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16678
GSE233548_2_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
301_ANAPC10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.748241
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2679
BRD-K42918627_GSK-2126458_MDAMB231_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7-Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
oxidative	GeneRIF Biological Term Annotations	1.0	null
STAT1	JASPAR Predicted Transcription Factor Targets	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.35351
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6285
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.9763
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03269
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4843-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4957_MED7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.973169
BRD-K43226598_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00903
CEBPZ_02_176	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63005
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	GO Molecular Function Annotations 2023	1.0	null
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
Lung adenocarcinoma_LUAD_TCGA-95-A4VP-01A-21R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17952126-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
BRD-A21858158_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261504
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21629
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.452577
PMC12381255-41389_2025_576_MOESM3_ESM.xlsx-Differentiated_SRCAP-1879-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
LIN7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0215
embryonic fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.106702
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.42318
hsa-miR-642a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
(RS)-PPG	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.742
Fast muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.837
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pallidohypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.37474
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE179031_3_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AE-04-SN76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24454
786_BCAS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.540431
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HUNS1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.86571
NCI-H1648	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A09115727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03138
REST-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K65883179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41758
Hairy root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.01
GTEX-OHPL-0126-SM-2HMJ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00851
hsa-miR-1262	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K55070890_thiothixene_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC4641642-pone.0142229.s010.xls-AP2-GeneSymbol_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
GATA2_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4731-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988374
BRD-K92428232_GSK-461364_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXA5_01_305	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.66331
KARPAS299	DepMap CRISPR Gene Dependency	1.0	7.49894
GTEX-T8EM-0826-SM-4DM76	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48838
SMAD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00637702
HIV_Infected-mDC_None_GSE42058	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.7871
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GMPPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00640007
S9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.704
nerve	GTEx Tissue Gene Expression Profiles	-1.0	-0.912377
hepatoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074201
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Postsubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31261
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320995
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.001
HCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00641668
CCND1-20090754-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5024-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
XIRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00548919
GTEX-WFG7-1626-SM-4LVMF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11402
BRD-K44227013_ponatinib_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cystathioninuria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
Rovs	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.107
BRD-K28790383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22314
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934274
GSE135514_8_v_7_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NMCG1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51002
Peeling skin syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.745
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071108
posterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.49981
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.973685
lens	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.289582
BRD-K59263278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19277
RCOR1	ENCODE Transcription Factor Targets	1.0	null
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.10863
6537_POLR1D_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.630008
ASH-3	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.89022
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081998
EBLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43944
GTEX-QV44-1026-SM-447CG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902038
CA3 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.63366
AASS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38473
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.85952
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.19014
MCF7	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.801574
CSNK2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24484
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17122
hnf4a_21852396_wao9_lof_human_gpl570_gds3926	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.019614
BRD-A60414806_VINCRISTINE SULFATE_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-11A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
KARPAS-299	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.60863
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4617-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RT4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.969695
ABTB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00604005
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Juvenile absence epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
Biofilm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.849
GTEX-P78B-0426-SM-2I5F5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16623
r10 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49659
GTEX-WHWD-0326-SM-3LK6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00949
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.22535
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.355942
BRD-A47598013_citalopram_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DB-34-QA60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210035
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.508462
3343_GFI1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.556333
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857479
Agranular insular area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07053
BRD-K23192422_L-6307_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K11095218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26307
SEMA4C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00786286
Prostate	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.35141
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A375	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.10629
E2F1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.455342
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.886444
PDGFD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566999
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
nucleus	LOCATE Curated Protein Localization Annotations	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14423
RBBP5	ENCODE Transcription Factor Targets	1.0	null
ATP-binding cassette (ABC) transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.253
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866002
response to oxidative stress	GO Biological Process Annotations 2015	1.0	null
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UJHI-0926-SM-4IHKF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826139
Prostatic Diseases	CTD Gene-Disease Associations	1.0	1.01776
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TP53INP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44467
GATA1	ENCODE Transcription Factor Targets	1.0	null
CTCF_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02045
GSE149880_0_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CA-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.36898
BRD-K41604824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.80123
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49328571_dasatinib_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
umbilicalcord	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.36536
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-697_elements_included_exclusively_in_HIF1_genes_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DB	CCLE Cell Line Gene Expression Profiles	-1.0	-2.87086
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of rna metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC10769395-media-2.xlsx-S2D_EF_Repressed_genes-Ebegboni_et_al_Supplemental_Table_S2D_Increased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39737
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.73207
LRGUK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00500332
BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K44366801_NCGC00182371-01_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14737
PBXIP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00594889
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.248
C11orf58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19225
DMS454	CCLE Cell Line Gene CNV Profiles	-1.0	-2.44352
H3K36me3_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88819_6_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
GTEX-WRHU-1026-SM-4E3ID	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27359
EDNRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52898
GSE110178_5_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K44227013_ponatinib_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4875-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLPI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00471714
9680_UTP14A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.963777
Glycyrrhizic acid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
PCNX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0063216
CRCGN014_HEPG2_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1675
OCIAML5	CCLE Cell Line Gene Expression Profiles	-1.0	-2.51921
RUNX1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K86953192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03381
BRD-K43601041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04542
ChIP_POU5F1_16518401	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
dorsomedial nucleus, terminal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76434
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC38A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00464418
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.61981
BRD-K81142122_STK249718_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	GO Molecular Function Annotations 2015	1.0	null
GSE148066,GSE157787_2_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A28970875_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC10181932-41588_2023_1366_MOESM4_ESM.xlsx-Supplementary_Table_2-Supplementary_Table_2_Additional_information_for_all_SOX9-dependent_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypermethioninemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24222
GTEX-XV7Q-0726-SM-4BRV6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48403
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
CBP-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PRPS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00624716
Signal recognition particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.007
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.24385
KDM1A	ENCODE Transcription Factor Targets	1.0	null
PMC4954754-elife-15550-fig3-figsupp1-data1.xlsx-HSF1_Genes-Unnamed_12_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPK5-1326-SM-4IHLE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916527
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4640-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49328571_dasatinib_HT29_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-MN-A4N1-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4520b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Lens epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.961
NCIH2141	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21044
BRD-K52751261_HY-10456_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
BRD-K54233340_Dorsomorphin dihydrochloride_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FAIM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00844193
E2F1	ChEA Transcription Factor Targets	1.0	null
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Gene_Name_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
substantia innominata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.825569
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A41451487_PK-11195_HA1E_24.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_17757_KD_Esrra/Esrrg_SRP217321	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204381
BRD-A09719808_NCGC00188536-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPS27A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00960854
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.8883
5659_NGDN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.554416
HCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00791801
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142684_4_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Vestibular sensory epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.752
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6488577-41598_2019_43010_MOESM2_ESM.xlsx-Proteingroups_MBD3_pos-Gene_names_MBD3	Rummagene Transcription Factor Associations 2026	1.0	null
AD-18-XC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306669
FOSL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00639604
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48859
GSE159678_4_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE199921_1_v_0_romidepsin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130217_5_v_3_sesn2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.387751
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K67860401_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
KLM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64888
ESRRB-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DF-00-BU08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.509414
BRD-K24132293_piperlongumine (HPLC)_CL34_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68985225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40435
outer SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00049
species	GeneRIF Biological Term Annotations	1.0	null
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.9997
CE-00-EK89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292398
OSI-027	DeepCoverMOA Drug Mechanisms of Action	1.0	0.7
BRD-K34533029_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76534306_ENROFLOXACIN_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48226
MGST1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00511836
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.31828
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.876113
Caspase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.59
BRD-A74904029_EI-231_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
actin filament polymerization	GO Biological Process Annotations 2015	1.0	null
BRD-K54233340_Dorsomorphin dihydrochloride_THP1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
ASH2L	ChEA Transcription Factor Targets	1.0	null
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02839
Perturb_7552_OE_IL1RN_SRP300901	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.61505
archaeal-type flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.131
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12527
BRD-K66089377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01678
BRD-K17059629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2087
UF-27-HS98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.580514
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_downregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05804044_AZ-628_A375_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K24838542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44032
Calpain complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.624
BRD-K49328571_dasatinib_A375_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RHOBTB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060651
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307186
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980715
GTEX-X5EB-0526-SM-46MVP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49138
Brain - Hippocampus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.46776
Proplastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.359
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86894
PAX3-FKHR-20663909-RHABDOMYOSARCOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
IFNA14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00409605
GTEX-Q2AI-0426-SM-48U13	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54585
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18316
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.8333
HNRNPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1249
KMS27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54208
lung fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.142307
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	GO Molecular Function Annotations 2025	1.0	null
Adult_Liver	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.40235
GSE196671_6_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39735
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17969
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.437
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067038
CHK1_KD_GSE54268_665_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K83972459_JWE-035_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HOP-92	GDSC Cell Line Gene Expression Profiles	1.0	1.67605
BRD-K06792661_Narciclasine_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF395	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27473
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78098006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23827
hl60	HPA Cell Line Gene Expression Profiles	-1.0	-1.3189
Tularemia	DisGeNET Gene-Disease Associations	1.0	null
Breast Cancer_Mammary Gland Tissue_GSE1872	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.48975
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K76166595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39036
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.43294
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14317
9398_TTI1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.884173
subthalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00021
cell part	GO Cellular Component Annotations 2015	1.0	null
PPP1R13L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43277
nucleus of diagonal band	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.893055
8-M-PDOT	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96972
PMC4333416-supp_gku1375_nar-02461-x-2014-File012.xlsx-AR-reg_genes_imapcted_by_siPIAS-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K09607752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89443
BRD-K31898235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95424
KNS-42	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81429
ETS1	ENCODE Transcription Factor Targets	1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.51789
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K32862555_NCGC00183412-01_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38077
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Photosystem I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.647
Photoreceptor inner segment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.595
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE191174_0_v_1_ccdc92_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93123848_RAF 265_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K46308702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40057
PMC4595011-pgen.1005555.s001.xlsx-MITF_UP-regulated-Ensembl_gene_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Thylakoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.113
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
metformin-4	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC11263679-41598_2024_66946_MOESM1_ESM.pdf-156-SPI1_SPI1	Rummagene Transcription Factor Associations 2026	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
OLIG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00602004
GSE101239_4_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.896867
BRD-K08300592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10662
GSE112860_0_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Type VI protein secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.967
Ralfinamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.51
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HB-92-XE24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.283817
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09782
NFIC_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mo-B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.35
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Hairy cell leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.32
BRD-K12067186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73652
CPSF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02652
periventricular stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23111
PMC12592558-41419_2025_8097_MOESM4_ESM.xlsx-downregulated_3_-_DATASET_1-RNA_Seq_analysis_upon_lncMB3_KD_in_D283_Med_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ADAMTS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16699
GSE171177,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE225656_0_v_1_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Idiopathic generalized epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
sulfafurazole-1603	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92241597_CHR 2797_HCC15_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K23162004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36448
SLC39A14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00596265
BRD-K18629365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38921
GSE215109_0_v_2_ep400_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BB-20-UU03_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224002
BRD-A26002865_V4877_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20982
Endocytic patch	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.778
monensin-2580	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.884
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.1041
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
pi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.69
posteroventral (inferior) parietal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25304
enzymes	GeneRIF Biological Term Annotations	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8339-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.918773
FAM3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95575
nucleus of the stria terminalis, medial division, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08942
GA10	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88352
BRD-K41887762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49163
BRD-K67016489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03862
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30073
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.35522
TCF12	ENCODE Transcription Factor Targets	1.0	null
stress	GeneRIF Biological Term Annotations	1.0	null
4956_MED6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.514671
Pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.396
estradiol-6200	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OVTOKO	DepMap CRISPR Gene Dependency	1.0	3.51758
BRD-K56653679_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
9328_TRRAP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.770827
GTEX-VUSG-0726-SM-3GIK1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868505
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU475	CCLE Cell Line Gene CNV Profiles	1.0	1.48205
PMC4498179-srep11671-s1.pdf-246-SOX7_SOX7	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WHWD-1826-SM-3LK6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915804
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.91412
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
paraterete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62872
NTRK2_drugactivation_66_GSE20358	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.57625
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE93918_1_v_3_clozapine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A35588707_TENIPOSIDE_THP1_6.0_h_1.25_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03601405_NCGC00242337-01_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE226249_5_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HTRA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0871
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NDUFB7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0042744
Lung Injury_Lung Tissue_GSE1541	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.53879
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.950942
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23535
R3HDM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0111325
GTEX-NFK9-0926-SM-2HMJU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25688
5426_NAA20_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.552518
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01762107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33944
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.562
Osteopetrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
picrotoxinin-2161	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
WI-38 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.289
SPDEF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525675
RUNX3	ENCODE Transcription Factor Targets	1.0	null
BRD-U74615290_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DDC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602984
CD-13-QZ32_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239588
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
NAP1L4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587996
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.865217
BRD-K49457424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09857
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.01957
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252901
ALAS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549327
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37593
mantle zone of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32624
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW403	DepMap CRISPR Gene Dependency	1.0	2.77204
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	1.0	1.17707
leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101503
Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KIF3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00592061
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19158
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.150086
lateral mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1668
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Tripartite ATP-independent periplasmic transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.275
BRD-K66847579_WZ-7043_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8816_TELO2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.628376
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981325
GSE162590_1_v_0_gsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48685
TMEM120A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497203
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
central part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2288
NCI-H2369	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01391
BRD-K45894579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09225
skmel30	HPA Cell Line Gene Expression Profiles	1.0	1.78029
Eplerenone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
KC-32-GO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235782
GTEX-PX3G-0126-SM-2I3EN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00295
SLC4A11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00609324
BRD-A19500257_geldanamycin_MDAMB231_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE98755,GSE98756_1_v_0_fbxl19_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.391615
Medial pretectal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.4708
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
decreasing	GeneRIF Biological Term Annotations	1.0	null
Uniplex complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.526
BLK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00629648
BRD-K01594666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14324
HOXA13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00708064
sebaceous gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.485156
ZFX-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.9066
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.52093
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18778
BRD-K90999434_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73610817_NCGC00183371-01_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.921102
HMGB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59226
skin	GeneRIF Biological Term Annotations	1.0	null
PAX3-FKHR-20663909-RHABDOMYOSARCOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K23149109_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8838
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75364
CD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00548404
BRD-K18888894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30077
Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	155.955
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.283545
PMC7403583-41598_2020_69884_MOESM2_ESM.xlsx-Sheet1-Supplementary_Table_1_Differentially_Expressed_Genes_FDR_q_0_05_in_U2932_ROCK2_KD_vs_Scrambled_shRNA_Constrols_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03189
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
RPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49197
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH716	CCLE Cell Line Gene CNV Profiles	1.0	1.45721
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78015078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05111
GSE81803,GSE81912_2_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CC-03-PW00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368035
BRD-K73227372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33607
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.893971
KDM5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01405
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EBF1-22473956-LYMPHODE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GRK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00638352
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0822
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08236
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SJRH30	CCLE Cell Line Gene Expression Profiles	1.0	1.41933
BRD-K70549064_EI-156_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K71247208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51073
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.55886
CTCF_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87909389_F3055_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K35708212_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HNF4A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125025_2_v_3_lyl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K81418486_vorinostat_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.95109
muscle	GeneRIF Biological Term Annotations	1.0	null
Root primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
Glutathione synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.88
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Left ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.263
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4PQ-0726-SM-3NMCR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87618
BRD-K29086754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5552
striatum_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15492
ASH2L-23239880-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Formate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.328
GSE111385_2_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CD72	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00569297
Parotid acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.543
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987835
BRD-K13662825_dinaciclib_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
vitamin c_homo sapiens_gpl570_gse11919	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A51777634_-666_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
KE39	CCLE Cell Line Gene CNV Profiles	-1.0	-2.16432
Perturb_9726_KD_SF3B1_SRP278642	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
496100520_HIP_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.07042
D458	DepMap CRISPR Gene Dependency	1.0	2.53444
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IER3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545164
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270937
BRD-K14696368_16759925_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8124_PRELID3B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.530934
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6436-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SJCRH30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.93621
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Nitrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.793
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.53786
HELT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45988
BRD-K35960502_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.61664
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.721
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K67856917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43551
GSE155567_3_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRXL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01723
PRPF4B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00464185
TMEM145	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15035
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503367
ADO	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00486475
P53-22387025-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RF-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.44809
GSE138019_3_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATM_KD_GSE54268_663_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Mediodorsal nucleus of thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34933
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ferredoxin-thioredoxin reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.511
9837_WDR70_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538728
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16242
BRD-K49865102_PD-0325901_HEPG2_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRDM1	JASPAR Predicted Transcription Factor Targets	1.0	null
NB1	DepMap CRISPR Gene Dependency	1.0	2.19796
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00418
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE226355,GSE226357_1_v_4_ybx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.595111
ERG-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20746
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67219
GTEX-X4EP-0326-SM-3P5Z6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51814
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0257
JD-44-KF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.637313
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59302
3-Hydroxyflavone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.54
P2URK562	DepMap CRISPR Gene Dependency	1.0	2.721
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE196117_1_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Golgi transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.335
primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04547
GTEX-S7SF-1626-SM-3K2AY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56938
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89714
superior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.89824
keratinocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.257907
Biofilm matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.045
BRD-K49328571_dasatinib_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K15694916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04257
BRD-K72501910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98204
Lung adenocarcinoma_LUAD_TCGA-73-7499-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20731
POU5F1-16518401-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GPR55	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0085395
CCR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00782545
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.592
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.984759
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7029036-41598_2020_59469_MOESM2_ESM.xlsx-NR4A1_vs_GFP_adj_pval_0_05-Gene_NR4A1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OHPN-0011-R7A-SM-2I5FI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896087
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lower basal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45953
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PKLR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00596949
Acifran	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
Retinal degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.25903
KB-92-MK13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250642
GTEX-X8HC-1626-SM-46MWE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22494
BRD-K06177900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.59418
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H1-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.873804
SLC22A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571646
NAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01509
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
transition metal ion binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-XUZC-1726-SM-4BRWS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34697
BRD-K39188321_Betamethasone_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K88344082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28407
Medial group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27915
CDC25C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549498
KYSE-510	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.944157
BRD-K93176058_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE218060_1_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MEIOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09487
BRD-K78659596_MLN2238_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.19275
DF-00-BU08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202568
hsa-miR-3190	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
ovary	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.14138
COX7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588649
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K30964193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65181
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4943_MED20_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.671603
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.509
RHAG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572284
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SA1-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.93031
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41544
Embryonic axis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.31
NDUFA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00633912
DAUDI	CCLE Cell Line Gene CNV Profiles	-1.0	-2.05332
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X3-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-5778-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.720431
5658_NFYC_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.716304
r3 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1695
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.405013
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47757
BRD-K31856043_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE189653,GSE203344_2_v_0_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2545
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Peptide methionine sulphoxide reductase MrsB	InterPro Predicted Protein Domain Annotations	1.0	null
leads	GeneRIF Biological Term Annotations	1.0	null
hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.093078
BRD-A37056613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7214
Esophagus - Gastroesophageal Junction	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.44965
PMC4595011-pgen.1005555.s001.xlsx-BPTF_UP-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
Field CA1, stratum pyramidale	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03854
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.796729
9420_TUBB_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557709
UF-98-OM26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346287
claustrum, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.82625
Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Amino acid metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.622
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1666
MCF7	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.93044
SDC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571103
SMYD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00687999
U-698-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
colon_8a	HPA Tissue Sample Gene Expression Profiles	1.0	0.881692
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.6334
ERG	ChEA Transcription Factor Targets	1.0	null
BRD-K69840642_HDAC6 inhibitor ISOX_NCIH2073_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HS695T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55903
GF-37-MB64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.424754
CEBPD	ENCODE Transcription Factor Targets	1.0	null
BRD-K67390061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02848
STAT3-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
AB-12-IS33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246698
Hyperargininemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
EKVX	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.4892
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K11107424_Tiotidine_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KHM1B	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69301
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARS-dORF6_36Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.39651
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3Y4-01A-51R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial part of the lateral habenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76556
GTEX-U3ZH-1126-SM-4DXUG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0294
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7056-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
valproic acid_homo sapiens_gpl96_gds1050	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K35963610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81127
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23635
H3K36me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CADO-ES1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.12529
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.372165
BRD-K54233340_Dorsomorphin dihydrochloride_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.603481
Blindness	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_16088_KD_Pml_SRP306364	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.46626
BRD-K83963101_MLN-8054_PC3_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sulfapyridine-2538	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TMEM184A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43215
Miracidium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.609
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.167
Lung adenocarcinoma_LUAD_TCGA-44-2655-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UACC893	CCLE Cell Line Gene CNV Profiles	1.0	1.51375
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
BRD-A77216878_manumycin A_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
outer CP in (rostral) midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12819
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXA1_OE_GDS4957_10_human_LNCaP prostate cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K56716645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31454
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.27894
BRD-K03147246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52656
BRD-K09560946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55743
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174428
BRD-K67075780_TGX-115_HA1E_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268363
Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE136894_1_v_3_psen1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CB-44-RT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.456042
SLVL	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.95264
CC-90-EX35_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348965
NB5	GDSC Cell Line Gene Expression Profiles	1.0	1.56109
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
BRD-K29707171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10176
TE-10	COSMIC Cell Line Gene CNV Profiles	1.0	2.59653
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SMC1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19221
troglitazone-1173	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.301
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.36782
Lhx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.0507
BRD-K90675978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01329
Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A84U-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K40175214_torin-1_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K27331198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.959
Lung squamous cell carcinoma_LUSC_TCGA-66-2790-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Renal tubular transport disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
17192395-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78867378_mw-A1-12_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266109
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
1718_CNOT3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.587174
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.74213
GTEX-WFG7-0426-SM-4LMK5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33102
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30273
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.70176
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2676
BRD-A36074203_Remacemide hydrochloride_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MPF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.71
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
CEACAM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00994967
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27404
BRD-K22679163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13674
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.900558
BRD-K55877261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61788
Perturb_4793_KD_Tex10_SRP056038	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PMC8755441-mmc3.xlsx-IRF7-Up-stat1-hela_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K52119965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60011
BRD-K13514097_S1120_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-X62O-0826-SM-46MW8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07681
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5191-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A90451247_KU-60019_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
merocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.745451
GTEX-QCQG-1326-SM-48U24	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06255
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11697
shsy5y	HPA Cell Line Gene Expression Profiles	1.0	1.34594
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K14520048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25106
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04667232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02213
NCIH1618	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71361
shows	GeneRIF Biological Term Annotations	1.0	null
Skeletal muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
9435_TUT1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.522895
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266872
GAA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00279821
intermediate stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14507
dorsal motor nucleus of the vagus (vagal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.49827
GTEX-WH7G-0326-SM-3NMBH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28163
GSE151612_0_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K38347298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00371
GTEX-REY6-1026-SM-2TF4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04381
RNF168	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.011449
GSE244072_4_v_6_tfeb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-86-QK08_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258085
JAG1_OE_GDS3571_40_human_endometrial stromal cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MRPS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59963
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.09041
BAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66013
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962139
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05269
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
Pancreas-mast cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.190252
CXCR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00433067
BRD-A56592690_PX12_RMGI_6.0_h_30.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7684-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07809
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11857
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06223
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3657
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1500	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.15828
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.097833
NCI-H716	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	4.27002
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
organelle	GO Cellular Component Annotations 2015	1.0	null
duodenum	HPA Tissue Protein Expression Profiles	1.0	2.08237
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.336
PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Staphyloenterotoxemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.573
HCC2157	CCLE Cell Line Gene CNV Profiles	1.0	1.97482
SLC2A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00721623
PCSK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005642
Mavorixafor	DeepCoverMOA Drug Mechanisms of Action	1.0	0.5
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CYP4A11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00867056
medial pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33219
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
BRD-A62182663_YK 4-279_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.04849
TMF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494764
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544476
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.606
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8782
CENPI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14676
FOSB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00586065
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.11
BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC2820592-NIHMS144142-supplement-8.xls-LMS_SAM_3-GENES_HIGHLY_EXPRESSED_IN_GROUP_III_LMS_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02708799_GSK-1059615_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GR-ST	GDSC Cell Line Gene Expression Profiles	-1.0	-2.32979
Ventromedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07928
EGR1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17405
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.899947
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K51575138_TPCA-1_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2785-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2582_KD_SRA_SRP032999	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01273
USF2	ENCODE Transcription Factor Targets	1.0	null
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.257
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
CSTB_KO_GSE47516_18_mouse_brain (P7 cerebellum, P30 cerebellum, cerebellar granule cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.485524
BRD-K78866450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47402
Perturb_1259_KO_Bap1_SRP253039	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
2251_DMAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.760033
paclitaxel_homo sapiens_gpl570_gse39042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10290283-biol-2022-0622-sm3.pdf-108-MSX1_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223241_2_v_0_cdkn2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Chlorosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
AKIRIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41956
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05938
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.879267
BRD-K64215924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47594
3866_HNRNPH1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.751935
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.42401
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.868486
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0726-SM-3LK5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44456
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R3RS-0126-SM-3GIJL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966925
496100385_TCx_dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02535
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224149
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0268
GATA5_KO_GDS4809_170_mouse_Lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.27511
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-IE-A4EH-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24459
response to stress	GO Biological Process Annotations 2015	1.0	null
ZNF281	ChEA Transcription Factor Targets	1.0	null
GTEX-P44H-0226-SM-2XCEU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848257
RT-112	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.16122
hepatoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071483
BRD-K07762528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33789
BRD-K99749624_S1003_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSTM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00648893
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.914684
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52059
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_2_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	239.198
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.376
BRD-K66526269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31946
NDUFA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00493479
BRD-K21284411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94828
GSE193027_1_v_0_krt19_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-0526-SM-47JY3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59358
Brain Lower Grade Glioma_LGG_TCGA-HT-7873-01B-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADAMTSL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551033
H-NS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.313
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26575
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53803
GTEX-WFON-2126-SM-3LK7O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22113
GTEX-Q2AH-1626-SM-3GAF8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53474
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.754596
ARSG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00580766
GTEX-S3XE-1026-SM-4AD4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902623
ZNF488	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79406
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975284
PMC6522222-NIHMS977514-supplement-Sup_Table_15.xlsx-WT3_WT5-Unnamed_0_POU6F2	Rummagene Transcription Factor Associations 2026	1.0	null
MEG01	CCLE Cell Line Gene CNV Profiles	1.0	1.5452
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04788
GSE225218_8_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21726
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZM-0826-SM-4DXU6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953757
GTEX-OXRP-0126-SM-3NB32	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859004
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
C1QA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00710995
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.919425
EP300_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K25165359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23969
BRD-K68143200_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4444
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4177
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.85009
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
kidney	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.14414
SCLC-22H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.985949
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85418
PMC10337103-13046_2023_2747_MOESM2_ESM.pdf-25-CREBZF_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anteromedial nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09072
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.923221
Outer mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.044
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular protein complex assembly	GO Biological Process Annotations 2015	1.0	null
SB 218795	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
SU-DHL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19538
CEBPB	ENCODE Transcription Factor Targets	1.0	null
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84688
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	160.626
GSE220520_6_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.4705
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01067
BRD-K79090631_CGP-60474_A375_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Right_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.17567
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31938
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.513414
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A74V-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3691-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41979
NB5	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.82267
BRD-K19724398_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE148262,GSE150691_1_v_0_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.53066
pepstatin-1328	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
prethalamic eminence	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9551
6276_PHB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.545791
BRD-K79090631_CGP-60474_HCC515_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K49865102_PD-0325901_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.70802
QKI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00759797
BB-09-GD09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.467542
CCSER1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00611165
DIPK2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52041
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ADNP_Deficiency - NULL MUTATION_GDS2540_691_mouse_E9 embryos - Heterozygous mutant	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K60952519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28912
BRD-K49865102_PD-0325901_MCF10A_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymphocytic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.459145
layer 3 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43053
PATZ1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	341.432
sk-hep-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.622639
FD-79-TC61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.370643
BRD-K49865102_PD-0325901_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K58336011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60928
layer 5 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39462
H3K36me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K55844427_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955467
GSE123022,GSE123030_2_v_6_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAF-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Prelimbic area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08119
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1094
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.73207
GTEX-U4B1-0326-SM-3DB8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26092
TT2 ES cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.718
RFX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51448
DOK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.84954
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Isl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.1758
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.447586
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
BRD-K57080016_selumetinib_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K05804044_AZ-628_A375_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null