association dataset threshold value standardized value NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.80314 Lung adenocarcinoma_LUAD_TCGA-73-4658-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U8XE-0426-SM-3DB91 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833923 QF-71-QI30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.573207 cerebellar cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.93811 POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K37942718 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35968 OB-06-WW76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.253191 doxorubicin_homo sapiens_gpl10558_gse42531 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RUNX1 ChEA Transcription Factor Targets 1.0 null BRD-K73839552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93685 BRD-K59445060 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47689 H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-GH-A9DA-01A-21R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE196540,GSE196542_4_v_5_dnmt3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE124410_3_v_5_stk40_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-S7PM-0006-SM-3NM8C GTEx Tissue Sample Gene Expression Profiles 1.0 1.07809 Lung squamous cell carcinoma_LUSC_TCGA-22-4596-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null small testis MGI Mouse Phenotype Associations 2023 1.0 null GSE158969_1_v_2_trastuzumab_human RummaGEO Drug Perturbation Signatures 1.0 null LIVF001-022 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.68253 GSE57871_5_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Trichostatin A_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152057 GSE155695,GSE155696_1_v_0_acetaminophen_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles 1.0 2.1299 USF1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Costunolide_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.01804 BD-18-MM33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.216497 YA-78-MS95_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.240301 SP2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.64122 Acute Myeloid Leukemia_LAML_TCGA-AB-2891-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HK-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TE-15-RO34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.428839 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.42223 HT1197 CCLE Cell Line Gene Expression Profiles -1.0 -1.4766 Extraocular muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.904 BGC823 CCLE Cell Line Gene CNV Profiles 1.0 1.33061 RXRA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.00016 protein modification process GO Biological Process Annotations 2015 1.0 null WC-09-GD62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.366706 Sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.188 TEAD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Charcot-Marie-Tooth disease dominant intermediate B DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.503 GTEX-XQ8I-0626-SM-4BOPT GTEx Tissue Sample Gene Expression Profiles 1.0 0.868746 H3K4me1_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null dorsolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22899 GSE182680,GSE182683_10_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-KR-A7K8-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EWS-26573619-CHIP-SEQ-HEK293-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H1_Derived_Neuronal_Progenitor_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.873873 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.931419 Brain Lower Grade Glioma_LGG_TCGA-P5-A5F6-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3R2-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_JNJ-26854165_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0192063 VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0321 GTEX-S33H-1226-SM-4AD69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.97335 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC8851354-Table_2.xlsx-Genes_reg_by_FUS-DDIT3-Supplementary_Table_2_Genes_significantly_regulated_by_FUS-DDIT3_expression_in_HT1080_cells_adjusted_p-value_0_05_and_log2_Fold_change_1_or_-1_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null protein binding GO Molecular Function Annotations 2015 1.0 null GTEX-XYKS-0002-SM-4BRWN GTEx Tissue Sample Gene Expression Profiles 1.0 0.843639 AA-22-UI44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.771166 HES2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.9295 NFYB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PANC0813 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.4549 BRD-K82922770 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8338 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Congenital myopathy 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.16 plant embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066263 BRD-K01717817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91662 BRD-K40674409 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25674 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null EP300_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPU-0011-R3A-SM-2XCAE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.948477 gonad TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.922405 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29X-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LN428 Achilles Cell Line Gene Essentiality Profiles 1.0 1.05228 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IA-76-ZU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.33386 posteroventral (inferior) parietal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.85607 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UF-27-HS98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.922753 AN3CA CCLE Cell Line Gene CNV Profiles -1.0 -1.60763 GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14145 BRD-K64001802 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12243 BRD-K54081441 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33794 GSE196671_6_v_1_obox4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE222047_0_v_1_imidazole_human RummaGEO Drug Perturbation Signatures 1.0 null CE-04-HT15_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.256593 H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NR2F2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J5-01A-21R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE213588_9_v_12_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null Skeletal muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.96 COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.53649 Rectum adenocarcinoma_READ_TCGA-AG-4021-01A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null USF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 5927_OGDH_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.516538 MCF7_MC1568_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.019739 sirolimus_mus musculus_gpl1261_gse21755 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PPARG-20887899-3T3-L1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HEC-1-A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.42932 Perturb_12848_KO_Kdm4a_SRP192379 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.84291 REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles 1.0 1.97968 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC5903287-NIHMS956886-supplement-Table_2.xls-THP1_THP2_cds_exp_up-gene_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null HMV-II COSMIC Cell Line Gene Mutation Profiles 1.0 null EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE203485_1_v_0_sunitinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-UPJH-0006-SM-3GACW GTEx Tissue Sample Gene Expression Profiles 1.0 1.12256 Peripheral Axonal Neuropathy DisGeNET Gene-Disease Associations 1.0 null SEM Achilles Cell Line Gene Essentiality Profiles -1.0 -1.23667 inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.14773 FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null BRD-K31013025 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42699 M band COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.631 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles 1.0 1.78715 Plasma membrane bounded cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 9210_TPP2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.9543 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 MOLT-4 COSMIC Cell Line Gene Mutation Profiles 1.0 null HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A48D-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE102757_1_v_0_panobinostat_mouse RummaGEO Drug Perturbation Signatures 1.0 null RUNX1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null uterus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-N7MS-0011-R7a-SM-2HMKN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0527 QA-07-KC40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.215276 AC-84-QG99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210455 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AF-99-HA02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.69743 POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43P-01A-31R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WDR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75753 CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Vastus medialis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.123 GSE148066,GSE157787_11_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null D542MG DepMap CRISPR Gene Dependency 1.0 3.28446 parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21978 QE-79-XO29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.276241 homeostasis/metabolism phenotype MPO Gene-Phenotype Associations 1.0 null CRCGN015_MCF10A_48H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00462 CFAP126 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00371 K562_AC480_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0184305 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RELA_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUZC-2126-SM-4BRW8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13991 GSE137144_5_v_7_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_SGI-1776 free base_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167599 hsa-miR-4260 TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.953697 GSE171180,GSE171181_0_v_1_e7107_human RummaGEO Drug Perturbation Signatures -1.0 null GSE220693_1_v_0_cgas_mouse RummaGEO Gene Perturbation Signatures 1.0 null TBX19 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1086 PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_19_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null HH CCLE Cell Line Gene CNV Profiles -1.0 -1.65606 AC-76-JB92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.251341 17683608-TableS2 GeneSigDB Published Gene Signatures 1.0 null BRD-K91043938 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.99097 GSE210101,GSE210114_6_v_9_urod_human RummaGEO Gene Perturbation Signatures 1.0 null GSE185519_3_v_0_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null 17676974-TableS2 GeneSigDB Published Gene Signatures 1.0 null GTEX-R55E-1126-SM-48FDZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21051 H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH1436 CCLE Cell Line Gene Expression Profiles -1.0 -1.81756 PMC9601604-NIHMS1841143-supplement-SuppTable-2.xlsx-FOXO3-specific_targets-FOXO3-specific_targets_1218_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF Rummagene Transcription Factor Associations 2026 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40763 orbital frontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07575 GSE131649_6_v_10_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null ELK1::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2199 BCLAF1 ENCODE Transcription Factor Targets 1.0 null BARD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72461 BRD-K73001304 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14068 BRD-K85965830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14182 BRD-K81619018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84104 GSE212486,GSE212488_0_v_1_gata4_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K77935284 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04846 BRD-K53387776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02301 Myofibrillar myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.345 H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE235390_4_v_2_lurbinectedin_human RummaGEO Drug Perturbation Signatures -1.0 null FB-66-UU47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.405558 Lytic vacuole membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.289 FLI1_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain - Substantia nigra GTEx Tissue Gene Expression Profiles 2023 1.0 1.19161 Malignant Hyperpyrexia Due To Anesthesia DisGeNET Gene-Disease Associations 1.0 null mediodorsal nucleus of thalamus_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.987466 FF-34-KW62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.253548 4554_LEPROTL1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.954043 H3K9ac_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Autosomal dominant centronuclear myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.096 CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.76003 IRF1 ChEA Transcription Factor Targets 1.0 null H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Tubular Aggregate Myopathy DisGeNET Gene-Disease Associations 1.0 null GTEX-WVLH-0011-R7A-SM-3MJFB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.995015 Sarcoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.721 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34465 plasma membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043892 GTEX-OHPK-0326-SM-2HMJO GTEx Tissue Sample Gene Expression Profiles 1.0 0.855064 BCL3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LE-40-JW92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.324623 BRD-K07614312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91812 BRD-K73795883 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82894 posteroventral (inferior) parietal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.915892 BRD-K05939258 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.42655 BRD-K89376872 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29887 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MAF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.2482 blood TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Sarcoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.699 KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.88968 BRD-K17582293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.06789 H4K8ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K67092184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32725 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051524 GTEX-T6MN-0011-R4A-SM-32QPG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18115 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOTO-0011-R6B-SM-4B65X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968924 GTEX-NPJ7-0011-R2a-SM-2I3GF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852789 Lung squamous cell carcinoma_LUSC_TCGA-85-7710-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lymphnode_5b HPA Tissue Sample Gene Expression Profiles 1.0 1.22191 Oculocerebrorenal syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.522 BRD-K91654198 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50537 GSE151782_4_v_7_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE203158_0_v_14_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE156115_2_v_1_igf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null key GeneRIF Biological Term Annotations 1.0 null BRD-K92791036 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02164 ABL1_mutant_179_GSE45452 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.60538 CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WQUQ-0006-SM-3MJF4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.31101 BRD-K21176717 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44732 PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WHSE-0011-R5A-SM-3P5ZO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37132 Lung adenocarcinoma_LUAD_TCGA-44-2668-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AA-22-UI44_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.40049 A549_Fulvestrant_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149336 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.130228 FOXA2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles -1.0 -2.92261 K562_PHA-680632_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0244068 K562_GSK J1_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145427 MEF2A ENCODE Transcription Factor Targets 1.0 null GTEX-X62O-0005-SM-46MV1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.891464 abnormality of the nervous system GWASdb SNP-Phenotype Associations 1.0 0.039022 GSE210580_5_v_2_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.869596 anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.825055 GTEX-NL4W-0011-R8a-SM-2I3G4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.934163 DB-54-GQ68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -7.02629 PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AH-0526-SM-2I3ED GTEx Tissue Sample Gene Expression Profiles 1.0 0.925555 K562_G007-LK_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0204513 MYBL2 ENCODE Transcription Factor Targets 1.0 null GSE204929_0_v_1_ywhag_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles 1.0 2.23776 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NPJ7-0011-R5a-SM-33HBK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15232 H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 mediodorsal nucleus of thalamus_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.24263 GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12363 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A1HR-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CF-87-AS90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.52784 BA-84-WN26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.16329 2932_RIPOR1_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 2.04518 ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20569 POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FARAGE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.34567 Integument TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-RVPU-0011-R9A-SM-3NM8E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71332 Semimembranosus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.051 LS-180 COSMIC Cell Line Gene Mutation Profiles 1.0 null POU2F1-35413990-HUMAN-ARPOSCRPROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null GSE152432_1_v_4_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.76584 DIFI DepMap CRISPR Gene Dependency 1.0 3.66752 DA-67-HS65_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.26922 GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.2296 Farage Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.46039 BRD-K76450447 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10306 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K71262871 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09047 GSE109913_1_v_2_bleomycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.66603 GSE192689_0_v_1_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null K562_Sirtinol_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157611 K562_BMS-536924_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0194117 Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SA-32-CC58_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.23292 GSE80537_0_v_2_adhfe1_human RummaGEO Gene Perturbation Signatures 1.0 null SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null SIHA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.843729 GSE210951_1_v_0_islr_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S3XE-0626-SM-4AD6B GTEx Tissue Sample Gene Expression Profiles 1.0 1.17062 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NUDHL1 CCLE Cell Line Gene Expression Profiles 1.0 2.46917 BRD-K02778241 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66198 organic substance biosynthetic process GO Biological Process Annotations 2015 1.0 null ZNF770 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 90.1684 K562_Alvespimycin_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179895 lytic vacuole LOCATE Predicted Protein Localization Annotations 1.0 null AU565_BREAST CCLE Cell Line Proteomics 1.0 4.08786 H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93X-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC4006 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17916 GSE239844_1_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null PL-21 COSMIC Cell Line Gene Mutation Profiles 1.0 null U-2-OS Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.32261 A172 DepMap CRISPR Gene Dependency 1.0 4.93696 GTEX-OIZF-0006-SM-2I5GQ GTEx Tissue Sample Gene Expression Profiles 1.0 2.52271 ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 73.1076 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Metabolism Reactome Pathways 2014 1.0 null neuromuscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.163729 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.90367 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K39688447 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73276 bipolar disorder GWASdb SNP-Disease Associations 1.0 0.545546 AC-35-CK01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.288775 SG in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.986816 cisplatin_mus musculus_gpl339_gse6206 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 4696_LSM6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.531194 GSE158834_11_v_3_palm_human RummaGEO Gene Perturbation Signatures 1.0 null K562_Regorafenib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0148226 ruffle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ZNF684 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60082 MEF2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null liver GTEx Tissue Gene Expression Profiles -1.0 -0.967233 GTEX-OOBJ-0006-SM-2I3F4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.41037 BD-73-TX58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.299836 PMC11665843-SYB2-18-218-s001.pdf-156-GTF2I_GTF2I Rummagene Transcription Factor Associations 2026 1.0 null BRD-K27352194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19438 GSE162739_6_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Autosomal dominant centronuclear myopathy ClinVar Gene-Phenotype Associations 2025 1.0 null GSE169205_0_v_6_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE210580_5_v_6_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE180277_0_v_1_bach2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.866425 ILF3-29590119-K562-HUMAN-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K73442516 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20098 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MZ in posterodorsal (superior) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11335 NE-94-VE83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.615072 WDR36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01771 ETV3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.0945 BRD-K71644199 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63802 H3K9ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A549_AMG-900_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0107666 PMC10789969-crt-2023-577-Supplementary-Table-S2.pdf-19-MECOM_MECOM Rummagene Transcription Factor Associations 2026 1.0 null GSE127790_6_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-UP-A6WW-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15265 Blepharoptosis DisGeNET Gene-Disease Associations 1.0 null Hypothalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.194 Atg12-Atg5-Atg16 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.832 GSE158834_0_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.87 ZC3H11A ENCODE Transcription Factor Targets 1.0 null PMC5110612__F1 PFOCR Pathway Figure Associations 2023 1.0 null Oxaprozin_SK-MEL-2 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0157782 GTEX-XQ8I-0226-SM-4BOPM GTEx Tissue Sample Gene Expression Profiles 1.0 0.903432 SW1088 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CORL47 CCLE Cell Line Gene Expression Profiles -1.0 -1.78881 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate portion of DFC (area 9/46) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.58176 Lung adenocarcinoma_LUAD_TCGA-55-7910-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.27949 BRD-K97332312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38228 inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.8526 lymphnode_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.33929 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1 ENCODE Transcription Factor Targets 1.0 null GSE212299_3_v_0_abi3_mouse RummaGEO Gene Perturbation Signatures -1.0 null shoot TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061318 MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NKX2-3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8293 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.879114 BRD-K87878529 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19631 GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles 1.0 1.14533 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Amp_AA-TCGA-Unnamed_22_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GSE175787_5_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null MCF7_MLN8054_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0229785 Inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.04 K562_ENMD-2076_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0210943 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_PJ34_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0138667 TBX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.4724 GTEX-WVLH-0011-R4A-SM-3MJFS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.879892 GTEX-WWYW-0011-R7A-SM-3NB3H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64911 BRD-K18783332 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56652 SKLU1_LUNG CCLE Cell Line Proteomics 1.0 2.38936 BRD-K87418665 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13022 Lung squamous cell carcinoma_LUSC_TCGA-43-6143-11A-01R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.01386 AA-99-HO76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.267982 phosphatidylinositol-3,5-bisphosphate phosphatase activity GO Molecular Function Annotations 2025 1.0 null rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.340641 BRD-K45819372 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13907 PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE240896,GSE240899_2_v_0_ccnt1_human RummaGEO Gene Perturbation Signatures 1.0 null A549_AMG-900_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0138848 seedling TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066263 polyhydramnios DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.984321 CRCGN016_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.36383 K562_Barasertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152842 PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XXEK-1726-SM-4BRVB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48738 BB-86-BE39_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.209225 mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.7905 an3ca HPA Cell Line Gene Expression Profiles -1.0 -1.15194 PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_9_CCF-Affected_Genes_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SN8G-0226-SM-4DM6B GTEx Tissue Sample Gene Expression Profiles 1.0 0.852345 FOXA1-25552417-VCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC8166871__F7 PFOCR Pathway Figure Associations 2024 1.0 null SW1990 DepMap CRISPR Gene Dependency 1.0 3.38525 Distal myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.584 PIAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.36382 E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBX15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.9331 SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-8201-11A-01R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null short sperm flagellum MGI Mouse Phenotype Associations 2023 1.0 null cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Asynchronous muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.64 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.997782 GTEX-X261-0011-R6B-SM-4E3J8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53464 Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.077 GTEX-WWYW-0011-R8A-SM-3NB3S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.97555 KMS27 DepMap CRISPR Gene Dependency 1.0 3.60101 abnormal muscle fiber morphology MPO Gene-Phenotype Associations 1.0 null BRD-K47461610 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24183 Synthesis of PIPs at the plasma membrane Reactome Pathways 2024 1.0 null GTEX-XBED-0526-SM-47JY3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08957 EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.42786 GTEX-SSA3-0005-SM-32QOT GTEx Tissue Sample Gene Expression Profiles 1.0 1.16539 GSE140997_4_v_3_nsun6_human RummaGEO Gene Perturbation Signatures 1.0 null Bone marrow cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 phosphatidylinositol metabolic process GO Biological Process Annotations 2023 1.0 null BRD-K56441027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21554 GSE152441,GSE152442_6_v_3_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NFK9-1626-SM-3LK5J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09075 TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles 1.0 1.092 GTEX-T5JW-0126-SM-4DM6K GTEx Tissue Sample Gene Expression Profiles 1.0 1.24485 Emg: Myopathic Abnormalities DisGeNET Gene-Phenotype Associations 1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNT-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.900717 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114992,GSE114993_0_v_3_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2914 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCI-AML5 COSMIC Cell Line Gene Mutation Profiles 1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TBX20-22080862-HEART-MOUSE ChEA Transcription Factor Targets 2022 1.0 null AF-41-QY60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.916719 variants GeneRIF Biological Term Annotations 1.0 null FOXA1_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE176008_4_v_1_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-FB-A5VM-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.44097 SP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE125862_2_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128730_3_v_5_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-SE5C-0326-SM-4BRWX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.975898 BRD-K68119260 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13266 SF539 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.866425 GTEX-WZTO-0011-R3B-SM-3NMC6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.861639 AD-16-HL96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.79324 BRD-K34741587 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65064 X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.62029 BRD-K96280720 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22083 nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.2882 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NPJ7-0006-SM-3GACR GTEx Tissue Sample Gene Expression Profiles 1.0 0.90468 GSE210150_0_v_1_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null epidermis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null KA-51-CQ55_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.477311 protein metabolic process GO Biological Process Annotations 2015 1.0 null BRD-K80761625 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46713 Bone marrow TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.423 9341_TSG101_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.774282 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.42131 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.92181 Lung adenocarcinoma_LUAD_TCGA-44-2657-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFYA ENCODE Transcription Factor Targets 1.0 null GTEX-S7SE-0005-SM-2XCEA GTEx Tissue Sample Gene Expression Profiles 1.0 1.32768 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.91678 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null uncovered GeneRIF Biological Term Annotations 1.0 null H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K87343552 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62597 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_2_MITF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SIX5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Right_Atrium Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.17676 GTEX-TKQ2-1726-SM-4DXUP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10156 BRD-K22065327 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.40006 K562_Triamcinolone Acetonide_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0124258 10663_ZNF830_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.519512 BRD-K79562803 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15099 H4K20me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Aminoglutethimide_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140966 UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.12134 RANGRF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74011 BRD-K22875065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42264 ALVA31 BioGPS Cell Line Gene Expression Profiles -1.0 -2.77987 EBNA1-20929547-CHIP-SEQ-RAJI-CELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PMC12260418-pnas.2425984122.sd02.xlsx-TEAD1_6fraction_test_result-Unnamed_3_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null BIRC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80653 GSE186483_1_v_4_lrrk2_mouse RummaGEO Gene Perturbation Signatures 1.0 null trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.01372 CRCGN017_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.062 regulatory GeneRIF Biological Term Annotations 1.0 null GTEX-N7MS-0011-R6a-SM-2HMJ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06175 ANXA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78137 SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.72796 GSE213588_9_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null SARS-CoV MA15_Day4_None_GSE49262 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.6126 respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043275 cytoplasmic part GO Cellular Component Annotations 2015 1.0 null SNU1196 DepMap CRISPR Gene Dependency 1.0 3.45448 NCI-H740 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K51535480 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66115 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6 ENCODE Transcription Factor Targets 1.0 null GSE207787_3_v_2_pdha1_human RummaGEO Gene Perturbation Signatures 1.0 null FA-36-VA24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.641943 POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K28937085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3255 ELK4_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE229973_3_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Jun JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.5339 GSE151090_2_v_1_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.948391 Perturb_14231_KO_Dpagt1_SRP230444 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 8.51223 CRCGN013_HEPG2_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2229 SW1417 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE151782_4_v_0_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null muscle fatigue MPO Gene-Phenotype Associations 1.0 null BRD-K44897610 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80754 K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.837945 8040_SLC35A4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.556394 H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null duodenum HPA Tissue Protein Expression Profiles 1.0 0.910487 BRD-K08811598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12569 GSE131377_1_v_0_spocd1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE128730_4_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null CUX1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Flight muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.688 GTEX-WHSE-1126-SM-3NMBU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02348 CRCGN014_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7992 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MIIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15387 FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17660535-TableS4a GeneSigDB Published Gene Signatures 1.0 null 8598_SUPT5H_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.660864 musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.505356 GTEX-XUZC-0326-SM-4BOO8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.865867 MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06596 RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K61316494 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.98233 MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null Hypertrophy CTD Gene-Disease Associations 1.0 1.47348 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BC-01-JL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.525299 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.825055 nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null AE-85-LR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.516741 Phosphate HMDB Metabolites of Enzymes 1.0 null Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.087 GSE203158_12_v_15_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null glycerolipid metabolic process GO Biological Process Annotations 2015 1.0 null FF-46-CU92_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.497131 496100317_FWM_no dementia_no TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.37078 GTEX-POYW-1126-SM-48TCI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.937569 BRD-K85513337 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39496 BRD-A20242387 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08248 13_AARS_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.521163 PPARG ChEA Transcription Factor Targets 1.0 null skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.611346 GSE150669_0_v_3_roxadustat_mouse RummaGEO Drug Perturbation Signatures -1.0 null FB-66-UU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.27727 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null liver HPA Tissue Gene Expression Profiles -1.0 -0.907865 GSE101239_4_v_2_valproic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null blood GTEx Tissue Gene Expression Profiles 1.0 1.42854 CRCGN014_HEPG2_3H:N12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7704 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_75_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K83994491 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59572 4578_LIG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.834242 DMS53 CCLE Cell Line Gene Expression Profiles -1.0 -1.55931 GSE148200_3_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null SP1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gracilis muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.865 JUND_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K72296840 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4156 SETDB1_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SRF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.13158 GTEX-S7SE-0011-R6A-SM-2XCD9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0002 BCL-2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.666 H3K9me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K47474571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05397 BRD-K38040305 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74774 Bolting stage TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.798 blood cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null t60-adrenal_consensus MoTrPAC Rat Endurance Exercise Training 1.0 2.67736 POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUYS-0005-SM-47JZ2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.54787 A172 COSMIC Cell Line Gene Mutation Profiles 1.0 null MHHES1 CCLE Cell Line Gene Expression Profiles -1.0 -1.9572 MCF7_Baricitinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0136092 YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A76A-01A-51R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K25312635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41265 BRD-K69740275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4419 POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL11A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5110612__F1 PFOCR Pathway Figure Associations 2024 1.0 null yy2_20215434_hela_lof_human_gpl570_gds3788 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.465759 adrenal gland HPA Tissue Protein Expression Profiles 1.0 0.910487 GSE190186,GSE190188_0_v_10_apoe_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A4PA-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCLC21H CCLE Cell Line Gene Expression Profiles -1.0 -2.40191 GSE153836_14_v_5_fluoxetine_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XPVG-0626-SM-4B65B GTEx Tissue Sample Gene Expression Profiles 1.0 1.27542 KM-12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.999232 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09966 CRCGN016_MCF10A.WT.HP_24H:F12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1725 membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.05556 NFKB1_01_167 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 9.45704 CA-75-HA22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.499207 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5551-01A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04209 GSE149035_3_v_5_hepacam_human RummaGEO Gene Perturbation Signatures 1.0 null TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5456-11A-02R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K88941096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36035 H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN012_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.87137 NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null A549_Panobinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0111022 parahippocampal gyrus, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.886184 GTEX-V955-0326-SM-4JBGV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04739 Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_EED226_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0205223 amygdalohippocampal transition zone, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08055 HCC1500_BREAST CCLE Cell Line Proteomics 1.0 2.37076 GTEX-SNOS-0926-SM-4DM7A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26848 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K37656403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33054 GSE193258,GSE193259_9_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null UT7 CCLE Cell Line Gene Expression Profiles 1.0 1.39462 POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Absent Reflex DisGeNET Gene-Phenotype Associations 1.0 null H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPMI-8402 COSMIC Cell Line Gene Mutation Profiles 1.0 null phosphatidylinositol monophosphate phosphatase activity GO Molecular Function Annotations 2023 1.0 null abnormal sarcoplasmic reticulum morphology MPO Gene-Phenotype Associations 1.0 null NFIC_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAL1-26923725-CHIP-SEQ-HPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.881081 ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0011-R6A-SM-4AT5K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29463 BHLHE40 ENCODE Transcription Factor Targets 1.0 null GA-87-BR97_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.246064 MCF7_Anacardic Acid_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0131664 Metabolism of lipids and lipoproteins Reactome Pathways 2014 1.0 null MERO25 DepMap CRISPR Gene Dependency 1.0 2.96652 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6467-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF Rummagene Transcription Factor Associations 2026 1.0 null Axonal spine COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.783 Sarcoma_SARC_TCGA-DX-A2J1-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcolemma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.662 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0035 BRD-K98625375 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34382 GSE128730_4_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null DBH_KO_GDS4324_362_mouse_Embryonic heart E10.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8302-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dinoflagellate cingulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.951 BRD-K35635390 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42263 post-mRNA release spliceosomal complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.937 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919801 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.60322 salivarygland_6c HPA Tissue Sample Gene Expression Profiles -1.0 -0.988778 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.969816 MCF7_Tanespimycin_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0109098 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18763 Foxl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.6415 FTC238 CCLE Cell Line Gene Expression Profiles -1.0 -1.4944 GSE184892_4_v_1_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null PMC3973337-supp_gkt1387_nar-02202-a-2013-File010.pdf-6-ZNF217_ZNF217 Rummagene Transcription Factor Associations 2026 1.0 null SP2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.7712 H3K4me3_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-145-5p MiRTarBase microRNA Targets 1.0 null NF-Y MotifMap Predicted Transcription Factor Targets 1.0 null GSE146156_2_v_3_tagap_mouse RummaGEO Gene Perturbation Signatures 1.0 null SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRF1 ENCODE Transcription Factor Targets 1.0 null seed TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063598 4959_MED9_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.6837 BRD-K88485670 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26568 11085_NON-TARGETING_NON-TARGETING Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.521831 TE11 CCLE Cell Line Gene CNV Profiles 1.0 1.39804 4940_MED18_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.513027 MCF7_ZM 447439_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160397 Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.69043 SCABER COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE171269_1_v_4_pioglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null BRD-K80443236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31175 inner CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.919685 AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null GTEX-P4QS-0926-SM-48TBS GTEx Tissue Sample Gene Expression Profiles 1.0 0.990237 Peripheral_Blood_Mononuclear_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 2.59791 primary auditory cortex (core)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.914377 VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.10921 ISTMES2 DepMap CRISPR Gene Dependency 1.0 5.16959 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null INSM1_lack of the seven N-terminal amino acids_GDS5066_404_mouse_pituitary glands GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80359 SKM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.41472 GSE147366_1_v_4_med13_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K37379978 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0456 BRD-K55638368 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01373 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lordosis DisGeNET Gene-Phenotype Associations 1.0 null GTEX-XOTO-0826-SM-4B65O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88846 H3K79me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K35480932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51199 cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042116 RUNX1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ruffle GO Cellular Component Annotations 2015 1.0 null centronuclear GeneRIF Biological Term Annotations 1.0 null BRD-K80880605 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18738 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A69786436 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14959 uterine cervix TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FOXP1 ChEA Transcription Factor Targets 1.0 null MDST8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.834953 urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.52865 K562_Pirarubicin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0150926 ETS1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBXT JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3574 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE203485_1_v_0_zdhhc2_human RummaGEO Gene Perturbation Signatures -1.0 null deltaEF1 MotifMap Predicted Transcription Factor Targets 1.0 null JD-44-KF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.575993 FXR MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-SUCS-0626-SM-32PM5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.835613 AM38 Achilles Cell Line Gene Essentiality Profiles 1.0 1.07596 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02061 GSE148066,GSE157787_0_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PSDG-0426-SM-2S1OF GTEx Tissue Sample Gene Expression Profiles 1.0 0.922616 H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles 1.0 1.09319 CRCGN010_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.85545 basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.3563 K562_AMG-900_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147012 BRD-K82637883 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70203 H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K85398599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22834 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55E-0011-R6A-SM-2TC5T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32987 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A7HU-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.55637 OC-10-FB51_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.242873 Fetal_Intestine_Large Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.01833 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PM-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Phagophore assembly site COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.595 DPY19L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46226 basolateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.960879 DC-51-WE27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.593344 primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13691 Spleen Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.823932 NCIH2110 CCLE Cell Line Gene Expression Profiles -1.0 -1.48333 Nemaline myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.318 17683608-TableS5 GeneSigDB Published Gene Signatures 1.0 null HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.902581 Lung adenocarcinoma_LUAD_TCGA-49-4488-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.69958 GI-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null U-2932 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.935498 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE198380_0_v_1_phgdh_human RummaGEO Gene Perturbation Signatures 1.0 null CA1 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04652 E2F1 ChEA Transcription Factor Targets 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5J6-01A-31R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148200_0_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE210580_0_v_1_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE255432_4_v_0_imeglimin_mouse RummaGEO Drug Perturbation Signatures 1.0 null K562_Carmofur_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0200503 MCF7_Ofloxacin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152792 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OAW42 Achilles Cell Line Gene Essentiality Profiles 1.0 1.30196 Synaptic vesicle protein transport vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.594 SIRT6 ENCODE Transcription Factor Targets 1.0 null WRNIP1 ENCODE Transcription Factor Targets 1.0 null MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE235516_0_v_1_zdhhc2_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K70935154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05704 SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.984598 GTEX-T5JC-0011-R9A-SM-32PLV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55467 BRD-K79954583 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83575 ZSCAN31 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.6436 K562_Valproic acid sodium salt_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0212834 biological_process GO Biological Process Annotations 2015 1.0 null KDM5B ENCODE Transcription Factor Targets 1.0 null u26684 HPA Cell Line Gene Expression Profiles 1.0 1.26888 GSE212299_2_v_1_abi3_mouse RummaGEO Gene Perturbation Signatures 1.0 null AUTS2-25519132-293T-REX-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K69594935 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47005 H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FEZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.3094 GSE166536_1_v_2_docetaxel_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QEL4-1326-SM-447AD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85822 GSE199204,GSE211619_4_v_6_glutamine_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE115542_2_v_1_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null Polyhydramnios DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.163 MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7686-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Large For Gestational Age DisGeNET Gene-Phenotype Associations 1.0 null TAL1 ENCODE Transcription Factor Targets 1.0 null GTEX-XLM4-0011-R4B-SM-4AT5C GTEx Tissue Sample Gene Expression Profiles -1.0 -0.840601 Perturb_1027_KO_Ovgp1_SRP379795 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.56532 USF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CMK115 CCLE Cell Line Gene Expression Profiles 1.0 1.56732 GATA1_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7PM-0011-R5A-SM-3NM8G GTEx Tissue Sample Gene Expression Profiles -1.0 -2.19114 MCF7_PD173074_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140294 GSE193258,GSE193259_5_v_13_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null K562_Daphnetin_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0220941 BRD-K79997957 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.9141 H3K9ac_Rectal Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC8160578-JCB_202009147_TableS4.xlsx-FOXM1_targets-Genes_n_696_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-NFK9-0926-SM-2HMJU GTEx Tissue Sample Gene Expression Profiles 1.0 0.944176 JSC-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.83296 BRD-K84794783 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36142 BRD-A84923154 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.27274 GSE223008_7_v_12_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null Congenital myopathy 4A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.354 BRD-K70949282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50562 PCM6 CCLE Cell Line Gene Expression Profiles 1.0 1.808 RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K00048792 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13531 cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.47215 Slow twitch muscle fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.684 Alx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.5796 H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ATF2 ENCODE Transcription Factor Targets 1.0 null GSE231891_1_v_0_cdk8_human RummaGEO Gene Perturbation Signatures -1.0 null A549_Panobinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0101463 SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.86616 GTEX-WHSE-0011-R1A-SM-3P5ZK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.926807 GSE211989_0_v_1_nlrc3_mouse RummaGEO Gene Perturbation Signatures 1.0 null NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Soleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.377 POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TGIF2LX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.0586 Vaesbj TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.84 BRD-K81537454 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.01627 GSE149903_5_v_2_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null pancreas_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.7301 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3Q0-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K63354944 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21608 GSE44157,GSE44163_3_v_0_nr6a1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE95685_2_v_3_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-S4UY-0526-SM-3K2AN GTEx Tissue Sample Gene Expression Profiles 1.0 1.31289 hsa-miR-4534 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.857913 PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1 Rummagene Transcription Factor Associations 2026 1.0 null MV411 CCLE Cell Line Gene Expression Profiles 1.0 1.55023 hmc1 HPA Cell Line Gene Expression Profiles 1.0 1.20642 impaired skeletal muscle contractility MGI Mouse Phenotype Associations 2023 1.0 null Charcot-Marie-Tooth disease type 4B2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.729 GTEX-Q2AI-0426-SM-48U13 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18485 BA-56-QV45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.032 reticulotegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.841011 FOS ENCODE Transcription Factor Targets 1.0 null NFE2L2-22581777-LYMPHOBLASTOID-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE185519_4_v_7_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null FA-80-DR66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.296338 BB-23-PM31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.200379 ZBTB33_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE190384,GSE190386_2_v_8_fulvestrant_human RummaGEO Drug Perturbation Signatures -1.0 null GSE118794_2_v_1_zmynd8_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K86897283 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44627 MZ in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09969 GSE228413_4_v_3_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.919158 viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5Q5-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K74651253 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01451 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.45038 BRD-K40266835 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05605 BRD-K60453579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92129 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TF1 CCLE Cell Line Gene Expression Profiles 1.0 1.63894 WM3772F DepMap CRISPR Gene Dependency 1.0 3.02634 CRCGN015_MCF10A.TP53.M_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8555 GSE218060_7_v_0_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RNOR-0011-R4A-SM-3GAD3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.85737 CRCGN015_MCF10A_48H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5725 occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28699 H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Type 1 diabetes mellitus_pancreatic islet_GSE2254 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.47093 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.14507 HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE148066,GSE157787_2_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BA-95-YU85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.372784 embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051886 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X3Y1-0726-SM-3P5YU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60577 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null HCC1599 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.979237 GSE161295_2_v_3_cdk8_mouse RummaGEO Gene Perturbation Signatures 1.0 null HM7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XXEK-1126-SM-4BRUX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.082 EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T8EM-0826-SM-4DM76 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40578 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.70786 spinal (inferior) vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.24949 tonsil_8e1 HPA Tissue Sample Gene Expression Profiles 1.0 1.2325 BRD-K02274100 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10113 CHD1 ENCODE Transcription Factor Targets 1.0 null glycerophospholipid biosynthetic process GO Biological Process Annotations 2015 1.0 null GTEX-WFJO-0926-SM-4LVM2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.04213 Lung adenocarcinoma_LUAD_TCGA-38-4632-11A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE114992,GSE114993_4_v_3_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null Myotube TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.33 bounding membrane of organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.05815 PMC12909843-41467_2026_68388_MOESM4_ESM.xlsx-fig3g-up-regulated_gene_expression_in_OTX2-KO_8CLCs_OTX2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.928197 FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null CRCGN015_MCF10A.TP53.M_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8765 MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE126463_6_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K15380626 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17114 H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_3_MITF Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Malignant hyperthermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.138 outer CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.875126 GSE139239_3_v_5_ddr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null RD-90-OY66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.5809 MCF7_CUDC-907_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0060397 metabolic process GO Biological Process Annotations 2015 1.0 null GSE158834_0_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4424-01A-22R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K24133999 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3509 H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.18075 JARID1A-20064375-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11218 BRD-K77869064 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01707 PMC12260418-pnas.2425984122.sd01.xlsx-TEAD4_6fraction_test_result-Unnamed_3_TEAD4 Rummagene Transcription Factor Associations 2026 1.0 null midbrain reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.51727 GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles 1.0 2.30374 HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.7615 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Limbic system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.194 Perturb_10438_Mut_Adad2_SRP262140 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.33204 dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.931547 GSE120612_7_v_3_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.872036 Perturb_4885_KD_TP53_SRP131666 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 NCIH1385 CCLE Cell Line Gene Expression Profiles -1.0 -1.71514 RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX3 ENCODE Transcription Factor Targets 1.0 null GTEX-U8XE-1226-SM-4E3HN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.985875 BRD-K30799912 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59926 GSE151782_6_v_7_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE235701,GSE261434_2_v_1_enasidenib_human RummaGEO Drug Perturbation Signatures 1.0 null Congenital Fiber Type Disproportion DisGeNET Gene-Disease Associations 1.0 null GSE142210_4_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2709-11A-01R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K91980109 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1248 BRD-K70851916 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31375 hippocampus (hippocampal formation)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0113 Tobacco Use Disorder HuGE Navigator Gene-Phenotype Associations 1.0 null REST ENCODE Transcription Factor Targets 1.0 null GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles 1.0 0.974495 8517_STK24_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.672214 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.871188 GTEX-XBEW-0006-SM-4AT4E GTEx Tissue Sample Gene Expression Profiles 1.0 1.07688 RPRD1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72365 Metabolism Reactome Pathways 2024 1.0 null 7657_SARS_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.743671 GSE192689_0_v_3_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE130383_1_v_0_gps2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.28553 Lysosomal lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.102 CRCGN015_MCF10A.WT.HP_24H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.28422 pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.0924 Perturb_146_KD_Mettl3_SRP033779 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.52031 BHLHE40_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K91180296 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15865 OF-05-CB18_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.353034 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.850637 RH41 CCLE Cell Line Gene CNV Profiles 1.0 1.36462 GTEX-NL4W-0011-R5a-SM-2I3GD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35045 GSE211126_3_v_0_hapln1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ETV7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.493 TEAD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1954 Achilles Cell Line Gene Essentiality Profiles 1.0 1.24021 HAUS8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06523 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.863706 KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.833714 BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.313518 TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_11354_KD_METTL3_SRP292229 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.79246 Lung squamous cell carcinoma_LUSC_TCGA-63-7023-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdaloid complex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.919422 MGA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7335 PSMD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45586 GTEX-PWO3-0926-SM-2I5EY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.873581 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XLM4-0011-R9A-SM-4AT45 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3724 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RM-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CORL24 CCLE Cell Line Gene Expression Profiles -1.0 -1.77972 K562_S3I-201_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0222309 BRD-K59821747 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67546 H3K4me1_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null PMC11193738-41467_2024_48647_MOESM8_ESM.xlsx-Data_S5-Data_S5_HNF4A-bound_gene_targets_identified_from_ChIP-Seq_in_hepatic_cells_D8_Hep_and_HepG2_cells_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A band COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.695 H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K03381861 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26331 RGS14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46426 GSE140074_1_v_0_kif20a_human RummaGEO Gene Perturbation Signatures 1.0 null PMC9195629-Table1.xlsx-Supplementary_Table_1-JUN_JUN Rummagene Transcription Factor Associations 2026 1.0 null MOLM16 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 hsa-miR-193b-3p MiRTarBase microRNA Targets 1.0 null K562_Hesperadin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0276341 PEO4 DepMap CRISPR Gene Dependency 1.0 5.00522 hsa-miR-24 TargetScan Predicted Conserved microRNA Targets 1.0 0.49473 HCC70 Achilles Cell Line Gene Essentiality Profiles 1.0 1.4092 hsa-let-7e-5p MiRTarBase microRNA Targets 1.0 null GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.0486 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB7A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARGFX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3066 GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles 1.0 1.92591 GSE169205_0_v_5_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null SRF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-EP-A3RK-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5463-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE201309_4_v_6_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K78397696 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56232 Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.106 YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCV JFH1_120Hour-Huh7_5_1_None_GSE29889 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.65595 GSE151782_2_v_7_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Phosphatidylinositol 3-kinase complex, class III COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.597 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.386273 BRD-K19036695 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18498 KDM5A ChEA Transcription Factor Targets 1.0 null BRD-K08939947 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42016 BRD-K95651150 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34296 phosphoinositide GeneRIF Biological Term Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5248-01A-01R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PA-TU-8988S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919801 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29H-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSU CCLE Cell Line Gene CNV Profiles 1.0 1.8588 EPI-1526-1 (BAG1) NURSA Protein Complexes 1.0 null Ptosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.413 GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles 1.0 1.28387 BB-42-FF52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.245539 lymph node HPA Tissue Gene Expression Profiles 1.0 1.15561 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KM-8443-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55F-0011-R8A-SM-2TF4F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.919384 BD-18-MM33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.453087 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SK-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXA2 ChEA Transcription Factor Targets 1.0 null BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 3.24385 RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QMR6-0011-R4A-SM-32PKU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862745 EBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LS 180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null SNAP23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14079 all GWASdb SNP-Phenotype Associations 1.0 0.030139 endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GTEX-P4PQ-0326-SM-2HMJ8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02025 BRD-K45713337 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11781 GSE146962_0_v_1_glucosamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K14070721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42512 GSE169205_3_v_5_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null KYSE-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31229 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MV-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K47109712 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14451 CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20589 BD-69-GX17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.410214 GSE158834_0_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdalohippocampal transition zone, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13915 GTEX-XMD1-0011-R2B-SM-4AT5N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36455 tonsil HPA Tissue Gene Expression Profiles 1.0 1.61261 A549_Prednisone_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140384 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4875-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7876_SH3BGR_P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.520763 MRPL38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0369 Gonadal sheath cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.596 BRD-K99022424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02292 YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 3986_HSPE1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.536929 RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MEL-24 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01885 BRD-K05001008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15453 GSE240896,GSE240899_10_v_0_ccnt1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K12343830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.188 STAT3 ChEA Transcription Factor Targets 1.0 null GTEX-NL3H-0011-R6a-SM-2I3G8 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.24379 lomofungin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 5.18383 GTEX-WZTO-0011-R1B-SM-3NMAR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26475 BRD-K20847739 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15596 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE175787_5_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.44861 BRD-K20259776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15016 BB-79-AG41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.320187 BRD-K18726958 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45407 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YAP1-20516196-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.996607 RERF-GC-1B COSMIC Cell Line Gene CNV Profiles 1.0 2.76305 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043263 GSE165704_0_v_1_rif1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PVOW-0011-R1A-SM-32PL6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58144 BB-86-BE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.33713 CRCGN017_MCF10A.WT.HP_24H:K18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0363 EP300_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24677 GTEX-R55E-0011-R1A-SM-2TC6N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12976 PMC6469946-aav1472_Data_file_S3.xlsx-PPARG_targets_UP_RNA-Seq_Young-Supplemental_Table_3_PPARG_targets_up_regulated_in_dKO_vs_CONTROL_RNA-Seq_Young_FDR_0_1_n_376_PPARG Rummagene Transcription Factor Associations 2026 1.0 null single-organism biosynthetic process GO Biological Process Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-1017-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K79048835 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29091 GSE152441,GSE152442_6_v_4_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null K562_IOX2_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0164598 BD-69-GX17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.802592 Peliosis hepatis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.092 NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.69846 embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052797 GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.874441 L428_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 2.41288 GTEX-PVOW-0011-R3A-SM-32PKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48964 kidney TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null K562_Enzastaurin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0180174 BRD-K19930413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00696 amygdaloid complex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.13274 NCI-H2347 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.32152 SA-53-XG95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.221285 Biceps TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.223 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Navitoclax_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0177082 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null myc_20940306_e13dot5_erythroblast_purified_from_liver_gof_mouse_gpl6885_gse18558 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.12997 X-linked monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.328 GTEX-WFG7-0426-SM-4LMK5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14163 PBX3 ENCODE Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4839-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Colonic cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 lateral reticular nucleus (principal part) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.61513 reduced male fertility MGI Mouse Phenotype Associations 2023 1.0 null BRD-A46778020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51555 Brain - Spinal cord (cervical c-1) GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.35436 BA-15-VE07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.30226 DOHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.74939 Kidney TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE236486_1_v_2_arnt_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles 1.0 1.76934 Anterior horn cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.642 dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.9518 Lung adenocarcinoma_LUAD_TCGA-78-7540-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A8O8-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29M-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE162739_2_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ME-31-RM40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.661627 GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 1.0246 POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE126463_5_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null muscle fibre TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.261964 POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.85521 Cardiovascular system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.192 Biceps femoris TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.975 K562_Decitabine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0186553 GSE179974_3_v_1_carboplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Sarcoma_SARC_TCGA-DX-A3M2-01A-21R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.876141 GSE92589_0_v_1_sirolimus_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE234334,GSE234336_1_v_0_zhx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HPAF-II Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00704 Cryptorchidism DisGeNET Gene-Disease Associations 1.0 null ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_0_v_4_palm_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K44684577 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13961 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K72029544 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6601 Atf3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.2975 REST ChEA Transcription Factor Targets 1.0 null NB-80-IM48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -5.13933 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.941623 ChIP_TCFCP2L1_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null A549_GSK-LSD1 2HCl_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0182703 GSE120413,GSE120447_4_v_2_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE95543_1_v_0_klhl41_mouse RummaGEO Gene Perturbation Signatures 1.0 null SREBF1 ENCODE Transcription Factor Targets 1.0 null BRD-K28274866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12928 CRCGN016_MCF10A.TP53.M_24H:G03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34649 SIX5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-Netherlands-602-2009(H1N1)_12Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.99865 GTEX-WY7C-2526-SM-3NB2N GTEx Tissue Sample Gene Expression Profiles 1.0 0.949769 1941_CTPS1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.731147 MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R53T-0426-SM-48FEM GTEx Tissue Sample Gene Expression Profiles -1.0 -2.5943 GTEX-PLZ6-0726-SM-3P619 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.97266 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AV-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PI Metabolism Reactome Pathways 2014 1.0 null YAP1-20516196-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Coffin-Siris syndrome 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.073 TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CORVET complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.536 cerebellum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.966146 SUM225CWN Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.1772 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0197 BRD-K40143134 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12966 DE-73-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.303163 Cytosol COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 K562_Thiotepa_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0207764 H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BICR 78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902711 cerebellar cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.52278 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8755441-mmc3.xlsx-IRF1-UP-mono_IRF1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Aspirin_HS-578T Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00420559 MFSD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51592 TOR4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28454 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null HSPB9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51894 GSE114992,GSE114993_7_v_2_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null FOXJ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19644 BRD-K69515345 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41422 NFE2L2-22581777-LYMPHOBLASTOID-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.868659 H3K4me1_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MZ in midinferior temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.837314 GSE165579_0_v_1_opa1_mouse RummaGEO Gene Perturbation Signatures -1.0 null AA-23-FM46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.439291 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A905-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Inclusion body myopathy with Paget disease of bone and frontotemporal dementia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.259 MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null vorinostat_homo sapiens_gpl10558_gse35242 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K77483143 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02582 GSE192689_0_v_2_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null NR2C2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVJO-0011-R6A-SM-2S1QN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.949429 GTEX-WYVS-0006-SM-3NMA7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.78611 GSE254517_1_v_0_irf7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE211286_4_v_6_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null sarcoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.395873 SIX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11639743-mmc2.xlsx-LIN28B-gene_name_LIN28B Rummagene Transcription Factor Associations 2026 1.0 null ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.870104 JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.02479 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5697-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AE-52-NW93_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.381744 Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.31 POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Arid5a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.2428 PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-Gene_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE242290_3_v_7_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.23 GSE184892_7_v_3_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XPT6-2026-SM-4B64V GTEx Tissue Sample Gene Expression Profiles 1.0 1.02108 X-Linked Centronuclear Myopathy DisGeNET Gene-Disease Associations 1.0 null GTEX-XMK1-0005-SM-4B665 GTEx Tissue Sample Gene Expression Profiles 1.0 1.90705 5205_MRPL21_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.501275 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.85193 hsa-miR-597 TargetScan Predicted Conserved microRNA Targets 1.0 0.257113 KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.811429 Talc_SW 1271 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0189605 SKMEL2 BioGPS Cell Line Gene Expression Profiles 1.0 1.50626 primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.874646 SAP30 ENCODE Transcription Factor Targets 1.0 null HSC3 CCLE Cell Line Gene CNV Profiles -1.0 -2.5271 1588_CHMP6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.845467 brain_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.34209 phosphatidylinositol phosphate phosphatase activity GO Molecular Function Annotations 2015 1.0 null BRD-K43558307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73593 BRD-K53293966 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4645 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32507 cellular metabolic process GO Biological Process Annotations 2015 1.0 null YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K83946740 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.63426 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.9051 GSE149359_2_v_0_asap2_human RummaGEO Gene Perturbation Signatures 1.0 null FOXA2-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSG-0626-SM-4KL1Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.874358 {centronuclear myopathy, autosomal, modifier of} OMIM Gene-Disease Associations 1.0 null AD-51-FB60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.670453 laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.923262 ticlopidine-1975 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K16525290 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89353 BRD-A37645929 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73449 mediodorsal nucleus of thalamus_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.12024 BRD-K79658624 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30754 H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA1 ENCODE Transcription Factor Targets 1.0 null BICR31 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN008_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.667 SP1 ENCODE Transcription Factor Targets 1.0 null Muscle Fibrillation DisGeNET Gene-Phenotype Associations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RELA ENCODE Transcription Factor Targets 1.0 null 10623_ZNF774_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.57189 YE-80-LN04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.393621 TCCSUP DepMap CRISPR Gene Dependency 1.0 2.41067 myb_16205643_mcf7_gof_human_gpl96_gse2815 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.892572 GSE122378_0_v_1_carmil3_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Areflexia DisGeNET Gene-Phenotype Associations 1.0 null LC-12-VN85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.407391 VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.89519 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ovarian surface epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.714 NFIC_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.80301 GTEX-X4XY-0526-SM-46MW1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838043 PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE149903_3_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE199255,GSE199356_6_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K33860558 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.32368 IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE203329_0_v_1_mettl5_human RummaGEO Gene Perturbation Signatures -1.0 null HMGN3 ENCODE Transcription Factor Targets 1.0 null PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CE-02-FZ80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.222112 LB647-SCLC Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.28746 H3K79me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Anxiety Disorders CTD Gene-Disease Associations 1.0 1.46304 K562_PHA-680632_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0219992 catalytic activity GO Molecular Function Annotations 2015 1.0 null GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.79886 CA-48-SW47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.41231 Protein-tyrosine phosphatase, active site InterPro Predicted Protein Domain Annotations 1.0 null GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles 1.0 1.30584 SMOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60846 GTEX-PLZ6-0126-SM-48TC6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.924163 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BCLAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6071_PARK7_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.51646 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_9_MITF Rummagene Transcription Factor Associations 2026 1.0 null SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TRIM28 ENCODE Transcription Factor Targets 1.0 null BRD-K21296995 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.20249 K562_SRT1720 HCl_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152466 H3K79me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Extrinsic component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.389 PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-KDM5B-Unnamed_7_KDM5B Rummagene Transcription Factor Associations 2026 1.0 null GSE226983_2_v_0_ddx5_mouse RummaGEO Gene Perturbation Signatures -1.0 null NFKB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66689 BRD-A14424697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47571 ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles 1.0 1.57211 EB2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.968107 BRD-K59484021 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67915 phospholipid metabolic process GO Biological Process Annotations 2015 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19O-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_1155_KO_Max_SRP150708 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -14.5305 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE137144_4_v_6_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null 1840_CPSF2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.804897 OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03518 ICC10 DepMap CRISPR Gene Dependency 1.0 2.09924 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8045971-Table_3.xlsx-vs_LPS_ctrl-Unnamed_4_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN016_MCF10A.TP53.M_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.1379 GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SYK_druginhibition_288_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.28444 GTEX-UTHO-0726-SM-3GAEN GTEx Tissue Sample Gene Expression Profiles 1.0 1.11463 GSE179974_3_v_0_carboplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TMED4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06103 single-organism process GO Biological Process Annotations 2015 1.0 null PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-gene_name_LTF Rummagene Transcription Factor Associations 2026 1.0 null Mesothelioma_MESO_TCGA-MQ-A4LV-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.835374 H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CSTF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69405 H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COR-L279 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.00434 TP63 ChEA Transcription Factor Targets 1.0 null GSE216273,GSE216292_14_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.363 first GeneRIF Biological Term Annotations 1.0 null FF-28-ES17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.818598 451Lu Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.27539 BRD-A95480808 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16869 H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null increased male germ cell apoptosis MGI Mouse Phenotype Associations 2023 1.0 null AE-95-UU45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.33456 phosphate-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null PMC10248509-Data_Sheet_5.CSV--Autophagy_AND_GSE41177_DE-Genes_NOT_GSE58294_DE-genes_NOT_GSE66724_DE-Genes_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null GSE57871_6_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.939636 Tibialis anterior TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.118 PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PX3G-1626-SM-2S1PT GTEx Tissue Sample Gene Expression Profiles 1.0 0.949207 BRD-K23232542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00174 GTEX-TML8-1826-SM-32QOR GTEx Tissue Sample Gene Expression Profiles 1.0 0.998443 BRD-K90127029 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29927 COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35445 BRD-K85234739 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39735 GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_MC1568_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0167636 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31229 hippocampus (hippocampal formation)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.24345 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06444 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_unique_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles 1.0 2.04564 H3K23me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Liver And Intrahepatic Biliary Tract Carcinoma DisGeNET Gene-Disease Associations 1.0 null BRD-K41709602 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.27343 GSE179002_0_v_1_caprin1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE162739_8_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S7SE-0011-R4A-SM-2XCDB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37812 POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.903401 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Flexion Contracture DisGeNET Gene-Disease Associations 1.0 null H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.88353 MAP1LC3B Pathway Commons Protein-Protein Interactions 1.0 null GSE133516_5_v_6_kat7_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K93817456 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17459 SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-5483-11A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.88033 GSE194358,GSE194361_0_v_1_kdm5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.884958 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Rucaparib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141699 EF-74-KW12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.488766 BRD-K00363054 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24772 GSE157383_0_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-A52377240 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78003 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.91479 GTEX-OIZH-0326-SM-2HMKC GTEx Tissue Sample Gene Expression Profiles 1.0 0.889405 ARID3A ENCODE Transcription Factor Targets 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_PF-573228_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0188476 inner SZ in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15956 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE196671_6_v_8_obox4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE125025_2_v_3_lyl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW837 CCLE Cell Line Gene Expression Profiles -1.0 -1.99731 BICR10 DepMap CRISPR Gene Dependency 1.0 4.88458 BRD-K45628030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45888 FE-64-KC49_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21488 EP300 ENCODE Transcription Factor Targets 1.0 null single-organism metabolic process GO Biological Process Annotations 2015 1.0 null urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MCF7_Resveratrol_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161445 SKBR3 DepMap CRISPR Gene Dependency 1.0 4.43595 BRD-K02374169 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31268 GSE229102_1_v_0_nr2f6_mouse RummaGEO Gene Perturbation Signatures -1.0 null SAT COSMIC Cell Line Gene Mutation Profiles 1.0 null intracellular part GO Cellular Component Annotations 2015 1.0 null NFYB ENCODE Transcription Factor Targets 1.0 null depression GWASdb SNP-Phenotype Associations 1.0 0.354749 Phosphatidylinositol 3-kinase complex, class III, type II COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.95 Phospholipid metabolism Reactome Pathways 2024 1.0 null HOXD12::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6412 GTEX-UTHO-0011-R6A-SM-3GIJW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.986348 GTEX-TSE9-0011-R9A-SM-3DB7Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4332 H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FF-28-ES17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.40659 E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K49424866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60281 particular GeneRIF Biological Term Annotations 1.0 null BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:H08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.42415 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null U-937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.87263 Phosphatidylinositol 3-kinase complex, class IA COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.746 Lung squamous cell carcinoma_LUSC_TCGA-22-5478-11A-11R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KINGS1 DepMap CRISPR Gene Dependency 1.0 2.83844 behavioral abnormality GWASdb SNP-Phenotype Associations 1.0 0.088205 STAT3-23295773-U87-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null AD-54-FG24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.203323 Flexor digitorum longus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.544 MRPS17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48421 Clumsiness - Motor Delay DisGeNET Gene-Disease Associations 1.0 null dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.2225 GTEX-XLM4-0011-R6A-SM-4AT4B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32551 PK-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22174 ventrolateral prefrontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.22762 JUND_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042023 mammalian phenotype MPO Gene-Phenotype Associations 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-O5YT-1026-SM-3MJGF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925167 RUNX1-22412390-EML-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K28488100 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37941 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles 1.0 1.34941 MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEACAM16 LINCS L1000 CMAP CRISPR Knockout Consensus Signatures -1.0 -0.0049439 Necrosis CTD Gene-Disease Associations 1.0 1.27286 GSE201309_1_v_3_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null IZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.75301 TCF12 ENCODE Transcription Factor Targets 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null CRCGN012_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.18816 fulvestrant-7096 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ETS1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null GSE232223_1_v_0_letmd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GATA3 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7B0-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null spleen_3b HPA Tissue Sample Gene Expression Profiles 1.0 0.847137 phosphoprotein phosphatase activity GO Molecular Function Annotations 2015 1.0 null PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K81821040 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61276 CRCGN014_HEPG2_24H:M15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80168 LS411N DepMap CRISPR Gene Dependency 1.0 2.25477 hsa-miR-4651 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTPBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02932 lateral tuberal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12724 YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Proximal Muscle Weakness In Upper Limbs DisGeNET Gene-Phenotype Associations 1.0 null SPI1_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE207611,GSE207612_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null acts GeneRIF Biological Term Annotations 1.0 null PMC12824906-mmc5.xlsx-Sheet1-Table_S4_Target_genes_of_FOXM1_and_their_expression_across_the_subtype_of_breast_tumors_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.964571 BL4774 (MTOR) NURSA Protein Complexes 1.0 null SKMEL30 DepMap CRISPR Gene Dependency 1.0 5.70018 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE213588_8_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null Apical tubulobulbar complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.68 TAL1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXF2 JASPAR Predicted Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4873-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPL-1026-SM-3MJGI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.903578 GSE103068_0_v_1_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7061-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-323-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 BRD-K20355073 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45089 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUU-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE229580_2_v_1_creb1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K50677542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49917 GSE148066,GSE157787_11_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R55E-0011-R7A-SM-2TC5Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.890755 Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K29338816 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00503 CRCGN013_HEPG2_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.69648 SP2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38436 GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.02264 GSE57871_8_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-VJYA-0326-SM-3GAEX GTEx Tissue Sample Gene Expression Profiles 1.0 0.918419 K562_Linifanib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161337 pancreas GTEx Tissue Gene Expression Profiles -1.0 -1.82011 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 6801_PRPF4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.620114 GTEX-WZTO-0011-R4A-SM-3NMC7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.883664 leukocyte TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-TMMY-0005-SM-33HBN GTEx Tissue Sample Gene Expression Profiles 1.0 0.868487 VDR-33458620-PRIMARYEPITHELIAL-HUMAN-PROSTATE ChEA Transcription Factor Targets 2022 1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.68908 H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles 1.0 1.76982 PB-09-OE00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.606518 FA-88-II68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.45234 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ8I-1926-SM-4BOOK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.99198 ELOB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18019 DJM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null cellular protein modification process GO Biological Process Annotations 2015 1.0 null Charcot-Marie-Tooth disease type 4B3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.278 PRC_Partial Depletion_GDS3531_563_human_U2OS cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles 1.0 1.43256 BRD-K62621376 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86966 GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18218 GTEX-NPJ8-0011-R4a-SM-2HML3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18648 vivo GeneRIF Biological Term Annotations 1.0 null hacat HPA Cell Line Gene Expression Profiles -1.0 -1.44151 POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K10221669 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1059 GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P44H-0011-R4A-SM-2XCEW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1389 10790_NON-TARGETING_NON-TARGETING Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.776358 disease GWASdb SNP-Disease Associations 1.0 0.023794 Dehydration_CNS - Brain - Hypothalamus (MMHCC)_GSE4130 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.70017 GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.85639 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AB-33-EM56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.682651 Dense body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.617 GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SNU-C2B COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_SB431542_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0123982 H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BA-72-YP01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.235317 SDF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2255 SNB19 BioGPS Cell Line Gene Expression Profiles -1.0 -1.03347 SRF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.911227 GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles 1.0 1.14986 1771_COPB1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.561804 RERFGC1B DepMap CRISPR Gene Dependency 1.0 2.25984 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TR-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null plumule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068012 BRD-K80535598 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28004 PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null JIMT1 CCLE Cell Line Gene CNV Profiles 1.0 1.40742 RCOR1 ENCODE Transcription Factor Targets 1.0 null GTEX-WYJK-1026-SM-3NM8W GTEx Tissue Sample Gene Expression Profiles 1.0 1.11908 GSE225684_0_v_2_tfap4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE179031_3_v_2_foxp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-NPJ8-0011-R7a-SM-2HMJV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22699 GSE70935_3_v_5_cyfip1_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K32170456 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29145 GSE242083,GSE242098_3_v_4_med1_human RummaGEO Gene Perturbation Signatures 1.0 null STAT3-23295773-U87-HUMAN ChEA Transcription Factor Targets 2022 1.0 null sirolimus_homo sapiens_gpl2895_gse16944 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HBE cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.662 H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ELK3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.0376 BRD-K10404799 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06477 H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2595 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.986987 EGR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RH-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 7466_RPL36_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.548227 Perturb_10396_KD_MAFB_SRP352813 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 16.022 znf217_22593193_mda_mb_231_gof_human_gpl570_gse35511 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.765704 Perturb_14868_KO_PU.1_SRP166067 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.01263 Liver TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Brain_Germinal_Matrix Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.14748 JUND_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149903_5_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Fluorouracil_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161196 REST-18959480-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZI-0005-SM-2XCED GTEx Tissue Sample Gene Expression Profiles 1.0 2.52401 Liver hepatocellular carcinoma_LIHC_TCGA-T1-A6J8-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.3147 organophosphate biosynthetic process GO Biological Process Annotations 2015 1.0 null PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K10011427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48304 GSE93309_2_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles 1.0 0.941072 ZNF460 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 142.967 BRD-K04652643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16156 WholeBlood BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.23078 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE123943_2_v_0_sox1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-A84695402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74226 hsa-miR-92a-3p MiRTarBase microRNA Targets 1.0 null TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8494348-pone.0257161.s002.xlsx-D20-NOT_ext_ext-NOT_ext-Gene_Name_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null PRDX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39791 Pexophagosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.823 GTEX-WFON-2026-SM-4LVMW GTEx Tissue Sample Gene Expression Profiles 1.0 1.14448 BRD-K57579659 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04117 6709_PPY_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.654662 PHF8 ENCODE Transcription Factor Targets 1.0 null Muscle Weakness DisGeNET Gene-Phenotype Associations 1.0 null GSE152441,GSE152442_6_v_5_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null SH3GLB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25574 dorsolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12641 BDCA4+_DentriticCells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.20968 GSE100102_2_v_6_cgas_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OHPN-0011-R4A-SM-2I5FD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42928 MCF7_PHA-680632_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149747 V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.13437 centronuclear myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.91173 MUTZ5 CCLE Cell Line Gene Expression Profiles 1.0 1.46885 Eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.203 GTEX-QMR6-0011-R1A-SM-32PKW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.952898 SKNMC CCLE Cell Line Gene CNV Profiles -1.0 -1.36159 K562_Aminoglutethimide_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0212192 CD105+_Endothelial BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.891262 VCAP_PROSTATE CCLE Cell Line Proteomics 1.0 7.32879 SW1783_CENTRAL_NERVOUS_SYSTEM CCLE Cell Line Proteomics 1.0 3.58827 CRCGN008_HEPG2_24H:L04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.00045 GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22223 Myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.296 RL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 2.00742 SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55E-0011-R5A-SM-2TC5N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851381 BRD-K60661821 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31419 GSE138468_3_v_6_dyrk1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K73730918 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52557 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BB-62-SZ35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.294862 WC-59-RG09_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.5801 BRD-K06116445 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05636 9482_UBA52_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.55862 GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CORL51 CCLE Cell Line Gene Expression Profiles -1.0 -2.29243 GTEX-S95S-0726-SM-4B64H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42739 SBF transcription complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.044 Fatty Liver CTD Gene-Disease Associations 1.0 1.11501 BRD-K81758631 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32089 Quadriceps TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.093 GTEX-OXRN-0011-R5A-SM-2I5EF GTEx Tissue Sample Gene Expression Profiles -1.0 -2.0923 dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.923983 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null phosphatidylinositol monophosphate phosphatase activity GO Molecular Function Annotations 2015 1.0 null GSE108326_1_v_0_doxycycline_mouse RummaGEO Drug Perturbation Signatures 1.0 null bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.74657 orbital frontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.62549 Lung adenocarcinoma_LUAD_TCGA-64-5778-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DOV13 DepMap CRISPR Gene Dependency 1.0 2.05117 GSE152441,GSE152442_7_v_5_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE203308_1_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K97921950 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08259 u138mg HPA Cell Line Gene Expression Profiles -1.0 -0.985099 LC1SQSF CCLE Cell Line Gene Expression Profiles -1.0 -1.94223 BRD-K58892587 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89938 OB-17-DQ74_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.231549 BRD-K34370545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22417 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.995002 BRD-K82105167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0168 H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-1207-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.131849 GSE126463_0_v_2_arid2_human RummaGEO Gene Perturbation Signatures -1.0 null CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.82372 TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE179002_0_v_8_caprin1_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary motor cortex (area M1, area 4)_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.851489 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I6-01A-12R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIX5_02_78 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59185 BRD-K52139780 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83736 BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.488358 GF-35-IT27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.665054 HPBALL CCLE Cell Line Gene CNV Profiles -1.0 -1.43826 lipid metabolic process GO Biological Process Annotations 2015 1.0 null 9341_TSG101_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.12597 K562_UNC1999_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0163891 EP300_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles 1.0 2.07074 ZNF667 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63908 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.01399 VSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0335 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VUSG-1726-SM-4KKZL GTEx Tissue Sample Gene Expression Profiles 1.0 0.833688 BRD-K65725294 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25308 CRCGN014_HEPG2_24H:N12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.51118 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046265 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.85894 GTEX-QDVN-2426-SM-2S1Q4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.36072 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPDEF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7596 GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39397 GSE147943_4_v_6_cited2_mouse RummaGEO Gene Perturbation Signatures 1.0 null AA-99-PN83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220699 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles 1.0 1.16606 SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UKE-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.26243 YWHAB Hub Proteins Protein-Protein Interactions 1.0 null PMC9380317-13045_2022_1327_MOESM3_ESM.xlsx-Table_S7-Table_S7_Top_500_differentially_modified_gene_bodies_between_MM_and_its_precursors_in_AA_patients_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null SP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.933455 Liver hepatocellular carcinoma_LIHC_TCGA-FV-A2QQ-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUW1-1726-SM-4BOOZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.88461 CRCGN013_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.10321 GSE57871_6_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null PMC5577301-in-17-237-s001.xls-AR_downregulated_DEGs-Liver_GSE13440_GENE_AR Rummagene Transcription Factor Associations 2026 1.0 null A549_BMS-536924_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0136856 H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.51285 BRD-A09961470 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23055 EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRO-0011-R2A-SM-3NB1W GTEx Tissue Sample Gene Expression Profiles -1.0 -2.51454 GSE122067_2_v_1_mtch2_mouse RummaGEO Gene Perturbation Signatures -1.0 null WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20506 GSE210580_0_v_12_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.54996 ZBTB33_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_PD173074_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0219962 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null female reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.083915 BRD-K10130686 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12035 PMC6299095-41389_2018_108_MOESM4_ESM.xlsx-T47D-TRPS1_peak-gene_symbol_TRPS1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K47906308 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4384 H3K56ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_79_MITF Rummagene Transcription Factor Associations 2026 1.0 null NCI-H1666 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20589 abnormal spermatogenesis MGI Mouse Phenotype Associations 2023 1.0 null H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XMD3-0006-SM-4AT5X GTEx Tissue Sample Gene Expression Profiles 1.0 1.57857 SPI1 ChEA Transcription Factor Targets 1.0 null CD19+_BCells(neg._sel.) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.00768 FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.797179 496100426_PCx_no dementia_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.54144 MCF-7/LCC9 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.711 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20506 BRD-K25200031 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.343 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39X-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE137144_2_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null CA2 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40514 CRCGN009_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.561 POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP4 ENCODE Transcription Factor Targets 1.0 null liver_c HPA Tissue Sample Gene Expression Profiles -1.0 -1.31781 impaired muscle contractility MPO Gene-Phenotype Associations 1.0 null GTEX-R55E-0011-R4A-SM-2TC5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08951 lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.913335 GATA3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1 ENCODE Transcription Factor Targets 1.0 null GSE114992,GSE114993_4_v_6_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100452_HIP_possible Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.78481 SCLC-22H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09966 brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE112761,GSE112767_2_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE179031_0_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null JE-72-KV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.287246 USF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K10048365 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35612 AB-71-CI37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.236997 MCF7_Droxinostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176483 PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-GeneName_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TSE9-0011-R1A-SM-3DB7E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27025 hippocampus (hippocampal formation)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.10252 SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q3-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.835758 Lung adenocarcinoma_LUAD_TCGA-55-8619-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE234514,GSE234516_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null QA-07-KC40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.78242 Amyotrophic lateral sclerosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.022 ptdins35p2 GeneRIF Biological Term Annotations 1.0 null SNU-283 COSMIC Cell Line Gene Mutation Profiles 1.0 null NANOG ENCODE Transcription Factor Targets 1.0 null GTEX-RM2N-0326-SM-48FD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68885 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06319 A704 CCLE Cell Line Gene CNV Profiles -1.0 -1.49012 RA-27-ST16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.413191 HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919801 SNU119 CCLE Cell Line Gene Expression Profiles -1.0 -1.69438 EZH2 ENCODE Transcription Factor Targets 1.0 null BRD-K88671309 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04175 outer CP in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.988155 Lung squamous cell carcinoma_LUSC_TCGA-56-7730-11A-01R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 1581_CHMP2A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.594143 YY1 ENCODE Transcription Factor Targets 1.0 null RERFGC1B CCLE Cell Line Gene CNV Profiles 1.0 2.15506 GTEX-UJHI-0126-SM-4IHLP GTEx Tissue Sample Gene Expression Profiles 1.0 1.43857 NA-30-HS87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.257165 TRIM39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03157 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-A03898562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43553 Brain - Anterior cingulate cortex (BA24) GTEx Tissue Gene Expression Profiles 2023 1.0 2.90695 GSE179531_1_v_0_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.977637 ENO3 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H1341 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.06127 SW1271 COSMIC Cell Line Gene Mutation Profiles 1.0 null RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dilated sarcoplasmic reticulum MPO Gene-Phenotype Associations 1.0 null GTEX-QDVJ-0005-SM-2TC5X GTEx Tissue Sample Gene Expression Profiles 1.0 1.54201 BRD-K67980271 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45061 GSE150349_0_v_1_msx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K46897949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42439 MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.931506 GTEX-S7SE-0011-R1A-SM-2XCDE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29921 PMC9675280-12950_2022_317_MOESM2_ESM.xlsx-LPS_vs_control-Unnamed_1_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K08431704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04759 Fat body TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.4 GSE112761,GSE112767_1_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null TGIF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.414 pre-autophagosomal structure membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.806606 KA-75-LP02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.77375 RPAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88573 GTEX-XBEC-1226-SM-4AT65 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06337 BRD-K96893659 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50396 17210682-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null hsa-miR-1206 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 U937 CCLE Cell Line Gene Expression Profiles 1.0 1.90574 BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13006_KO_C3_SRP235282 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.00411 GSE148066,GSE157787_0_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PVOW-0011-R5A-SM-32PL7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05399 GTEX-WL46-0011-R10A-SM-3MJFQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.8565 primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.55073 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PXR (PXR:RXR) MotifMap Predicted Transcription Factor Targets 1.0 null BD-49-MD69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.2217 K562_Dacinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153221 central gray of the pons, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.96829 AE-39-DG66_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.23423 H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null PMC5542661__F1 PFOCR Pathway Figure Associations 2023 1.0 null Centronuclear myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.169 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null vertebrate muscular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.690042 ME-31-RM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.703928 IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.25924 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UTHO-0011-R1A-SM-3GIJO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17351 FOXA2-19822575-HEPG2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CA-68-KG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.30282 CRCGN012_HEPG2_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.86349 primary motor cortex (area M1, area 4)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.845987 Metabolism of lipids Reactome Pathways 2024 1.0 null HA-22-CY42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.372629 IC-76-JU42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.571071 CEBPG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.9987 PMC9434001-Table_1.XLSX-Sheet_1-ZBTB7B_ZBTB7B Rummagene Transcription Factor Associations 2026 1.0 null CHD1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K90231936 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05474 PMC9675280-12950_2022_317_MOESM3_ESM.xlsx-siPAD2_LPS_vs_siCON_LPS-Unnamed_1_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE155162,GSE155169_1_v_3_buparlisib_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-6846-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K10876822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44353 Fatty acid elongase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.793 BRD-K86946907 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.33829 GSE211286_1_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-A77697958 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22874 MAFK JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.4992 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null glycerophospholipid biosynthetic process GO Biological Process Annotations 2023 1.0 null Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.933 GTEX-XQ3S-0126-SM-4BOO9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10341 Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A76B-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null External Ophthalmoplegia DisGeNET Gene-Disease Associations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V1-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skeletal muscle cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.188 GTEX-Q2AH-2026-SM-2S1PX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.982206 GSE115542_5_v_4_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null RPMI 2650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.971919 Exercise-Induced Myalgia DisGeNET Gene-Phenotype Associations 1.0 null Respiratory Insufficiency Due To Muscle Weakness DisGeNET Gene-Phenotype Associations 1.0 null GTEX-POMQ-0126-SM-48TD6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.970349 GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.7745 GSE120216_3_v_0_cbfb_human RummaGEO Gene Perturbation Signatures 1.0 null L3MBTL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82275 POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EM2 DepMap CRISPR Gene Dependency 1.0 2.37517 GC-69-JF03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.284077 MCF7_Gandotinib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.013269 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null K562_Belinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153868 ND-39-PO34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.456965 Ptosis DisGeNET Gene-Disease Associations 1.0 null GSE175787_13_v_7_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K73995655 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19867 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A624-01A-22R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149901_3_v_0_anlotinib_human RummaGEO Drug Perturbation Signatures -1.0 null 10237_ZNF250_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.514347 TGIF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2612 HCC1482 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.31748 hsa-miR-339-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 FOXO1-32281255-CHONDROCYTES-HUMAN-OSTEOARTHRITIS ChEA Transcription Factor Targets 2022 1.0 null primary motor cortex (area M1, area 4)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.31777 HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC4-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null IL17RE LINCS L1000 CMAP CRISPR Knockout Consensus Signatures 1.0 0.00613835 HCA-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.94621 X-linked dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.002 AD-86-OB87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.308956 PMC11732233-mmc1.pdf-142-NANOG_NANOG Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null DAUDI COSMIC Cell Line Gene Mutation Profiles 1.0 null AR-27623747-22RV1-MOUSE-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null BC-61-ZY95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.287576 K562_Flavopiridol HCl_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0187832 CRCGN010_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.63848 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null JUND_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A1KX-01A-22R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null midbrain reticular formation, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.927428 ERBB2_druginhibition_8_GDS2139 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.08033 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5455-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K97763545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57825 PKNOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4929 CRCGN017_MCF10A.WT.HP_24H:I19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.2345 ETS1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DB-21-FY75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.890398 NRL_Deficiency_GDS2936_629_mouse_Retinas - 2 days GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046678 BRD-K49490091 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09928 GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles 1.0 2.47398 evidence GeneRIF Biological Term Annotations 1.0 null BRD-K14451397 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90582 Brain Lower Grade Glioma_LGG_TCGA-HT-7857-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K31059159 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.7784 GSE154767_1_v_5_adam10_mouse RummaGEO Gene Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8373 496100397_PCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.06467 GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5645 POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SG-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XMD1-0011-R5A-SM-4AT47 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.897778 KDM5A ENCODE Transcription Factor Targets 1.0 null GTEX-WZTO-0011-R7B-SM-4E3IS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872256 GSE172295_1_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K99873441 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.5905 JUN_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22174 GTEX-R55F-0011-R6A-SM-2TF4L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.936236 GSE206400_3_v_2_nusinersen_mouse RummaGEO Drug Perturbation Signatures -1.0 null phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO Molecular Function Annotations 2023 1.0 null Lysosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.29 GTEX-XUJ4-0226-SM-4BOP8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.972289 MCF7_Maraviroc_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0226814 BRD-K58194737 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13092 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IL-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JC-0011-R1A-SM-32PM6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4242 GTEX-RU72-0011-R7A-SM-2TF5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74387 GSE76771_1_v_3_atf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.55048 GTEX-NL3H-0011-R3a-SM-2I3GL GTEx Tissue Sample Gene Expression Profiles -1.0 -2.02372 GSE210580_5_v_11_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Foxo3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.7047 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AICD_Induced expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02061 GB-73-QS80_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208997 TFCP2L1 ChEA Transcription Factor Targets 1.0 null POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null single-organism cellular process GO Biological Process Annotations 2015 1.0 null SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cardiovascular system phenotype MPO Gene-Phenotype Associations 1.0 null VMRCLCD CCLE Cell Line Gene Expression Profiles -1.0 -2.6233 MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Slow Progression DisGeNET Gene-Phenotype Associations 1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN010_HEPG2_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.20422 POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE151829,GSE151831_3_v_0_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null STAT4 MotifMap Predicted Transcription Factor Targets 1.0 null HEC1B CCLE Cell Line Gene CNV Profiles 1.0 1.56833 BICR31 CCLE Cell Line Gene Expression Profiles 1.0 2.53474 H3K4me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null abnormal emotion/affect behavior GWASdb SNP-Phenotype Associations 1.0 0.261095 GTEX-XV7Q-0926-SM-4BRVQ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.04499 phosphatidylinositol biosynthetic process GO Biological Process Annotations 2015 1.0 null GSE77108_6_v_7_saha_human RummaGEO Drug Perturbation Signatures 1.0 null GSE173578_1_v_0_atf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hmga1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.9668 BRD-K91459693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26611 EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SH-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K60192542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13803 POT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10205 lysosome LOCATE Predicted Protein Localization Annotations 1.0 null PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K22475995 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16886 RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9804_WDR12_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.625765 REST_PFSK-1_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null impaired exercise endurance MGI Mouse Phenotype Associations 2023 1.0 null BCL6B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.0712 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BEN CCLE Cell Line Gene CNV Profiles 1.0 1.48095 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.93927 H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.927134 PL-21 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.75808 CRCGN014_HEPG2_24H:M14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.12082 FOXA2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K81385845 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09469 GSE210580_4_v_1_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K70843862 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74898 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null organophosphate metabolic process GO Biological Process Annotations 2015 1.0 null GSE141328_3_v_2_rock2_mouse RummaGEO Gene Perturbation Signatures -1.0 null KYSE-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08363 MAFK_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF3 ENCODE Transcription Factor Targets 1.0 null K562_Toremifene Citrate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0188158 H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K53095870 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.79705 EE-64-WM03_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.264734 EFO21 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.26573 BRD-K72441510 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75053 OV-7 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.1559 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5191-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X88G-0008-SM-47JWN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.933958 anterior (rostral) cingulate (medial prefrontal) cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18773 GSE223540_1_v_3_anxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null encodes GeneRIF Biological Term Annotations 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.845415 SYK_knockdown_280_GDS3609 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.5752 CRCGN014_HEPG2_24H:L05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5932 GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles 1.0 1.53025 BRD-K81982648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09104 Prostate adenocarcinoma_PRAD_TCGA-G9-6338-01A-12R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.58952 DDX60L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02813 BRD-K44494409 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14895 vascular tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.123209 SIN3A_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.081 H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 pallidohypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.66984 H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal calcium ion homeostasis MGI Mouse Phenotype Associations 2023 1.0 null BRD-K63757821 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.77211 AE-39-DG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.656072 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.20759 Foot TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.037 AA-68-OJ16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.229001 DMS53 CCLE Cell Line Gene CNV Profiles -1.0 -2.08705 primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11634 SIN3A_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles 1.0 3.34188 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.71406 Kidney Chromophobe_KICH_TCGA-KL-8331-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bone structure disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.081 dephosphorylation GO Biological Process Annotations 2015 1.0 null GSE223008_11_v_2_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE112763,GSE112767_4_v_1_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-UJHI-0626-SM-3DB8T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16748 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CDC34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29174 ATG2-ATG18 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.913 CRCGN011_HEPG2_24H:N09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2784 PAX5 ENCODE Transcription Factor Targets 1.0 null male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 MCF7_PCI-34051_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0169635 BCL6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9832 CAL27 CCLE Cell Line Gene CNV Profiles -1.0 -1.44054 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25S-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.846623 GTPase activator complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.14 SIN3A ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-38-4626-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NPJ7-0011-R1a-SM-3GACT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04152 GTEX-PSDG-0005-SM-3GADC GTEx Tissue Sample Gene Expression Profiles 1.0 1.49457 BHLHE41 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1502 4043_IFITM3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.576109 GSE154767_4_v_3_adam10_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC8593586-mmc2.xlsx-LIN28A_interactome-Unnamed_1_LIN28A Rummagene Transcription Factor Associations 2026 1.0 null SNU46 CCLE Cell Line Gene CNV Profiles 1.0 1.91586 FOXP2-23625967-PFSK-1 AND SK-N-MC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE92457_7_v_8_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null EP300_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.45835 PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null dorsal thalamus_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.75342 CA14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.86596 GTEX-NPJ8-0011-R6a-SM-2HMKB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12537 TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7516_RPS27A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.679244 Acute Myeloid Leukemia_LAML_TCGA-AB-2825-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 5331_MTMR14_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.52183 GSE151782_2_v_0_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Foreskin fibroblast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.611 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5081-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE165682_2_v_1_ptbp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE148200_0_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null cases GeneRIF Biological Term Annotations 1.0 null IV Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.931147 Sarcoma_SARC_TCGA-IS-A3K7-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JC-0011-R10A-SM-32PM2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.868756 LF-94-HB11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.316845 CRCGN012_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.13588 CRCGN016_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.24775 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1DE-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null orbital frontal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.0678 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NB6 DepMap CRISPR Gene Dependency 1.0 4.80694 mood disorder GWASdb SNP-Disease Associations 1.0 0.284539 nfe2l2_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.944938 GSE117730,GSE117732_0_v_2_apobec2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null P31-FUJ COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-S33H-0005-SM-2XCAL GTEx Tissue Sample Gene Expression Profiles 1.0 1.15196 hsa-miR-877-5p MiRTarBase microRNA Targets 1.0 null cerebellar cortex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.05455 sarcolemma COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.182422 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE154577_13_v_5_plagl1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-U3ZN-0226-SM-3DB8D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.901815 primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.956279 GSE201309_1_v_8_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null SPI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRL-0326-SM-2I3F2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.973371 USF1_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RT-A6YC-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEY2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1078 CAL33 CCLE Cell Line Gene CNV Profiles -1.0 -1.81487 BRD-K48276655 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14325 Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 plant form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062032 Amphisome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.157 Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWO3-0011-R6A-SM-2I5F3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.887967 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null Liver Neoplasms CTD Gene-Disease Associations 1.0 1.01324 TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.05444 JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.11706 GTEX-Q2AG-0011-R9A-SM-2HMJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76961 hsa-miR-4652-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 pineal_night BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.43421 H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GATA3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles 1.0 1.8352 GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 0.910092 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K21479004 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81454 DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.47557 GSE151090_2_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mesothelioma_MESO_TCGA-NQ-A57I-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null AR-20517297-VCAP-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1182 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 Foxf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.9982 GTEX-TKQ1-0006-SM-33HBI GTEx Tissue Sample Gene Expression Profiles 1.0 1.43562 CRCGN012_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.27997 GSE151090_0_v_4_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Twitch muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.015 Neuromuscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.885 T-tubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.756 GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles 1.0 1.83545 amygdaloid complex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.946537 Autolysosome lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.999 Congenital structural myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 3.172 GTEX-X638-0005-SM-47JX6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.78489 CRCGN008_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8052 BRD-A12894472 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78665 medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.71219 GSE203267_0_v_1_alkbh5_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K34501072 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62826 Perturb_1724_KO_Tet2_SRP353433 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -16.4516 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Facial Paralysis DisGeNET Gene-Disease Associations 1.0 null superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.1888 Diencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.194 H3K9ac_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.64532 t-tubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.406361 GTEX-NL4W-0011-R2a-SM-2I5GV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17256 D-myo-inositol-5-phosphate metabolism HumanCyc Pathways 1.0 null Cranial nerve disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.087 cellular_component GO Cellular Component Annotations 2015 1.0 null GSE215314_0_v_1_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Spleen GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.25729 CRCGN015_MCF10A.TP53.M_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6257 catalytic GeneRIF Biological Term Annotations 1.0 null CRCGN011_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7283 ZBTB33_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AA-52-JS03_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.286353 PMC11093744-41592_2024_2172_MOESM3_ESM.xlsx-ELP-genes_NR5A1 Rummagene Transcription Factor Associations 2026 1.0 null SC-19220-7095 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Liver GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.10614 OCILY19 CCLE Cell Line Gene Expression Profiles 1.0 1.94768 primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00319 496100415_PCx_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.22118 ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FC-13-VS25_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.75931 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles 1.0 1.37894 GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.48903 GB-57-XV52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.31727 Runx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.797 Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NN-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EP300_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 3-phosphoinositide degradation HumanCyc Pathways 1.0 null BRD-K83562499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.41714 K562_GSK1070916_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155482 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null ARIH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04154 GTEX-N7MS-0011-R4a-SM-2HMKW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.873999 hsa-miR-592 TargetScan Predicted Conserved microRNA Targets 1.0 0.598666 GSE180641_0_v_1_zfp503_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE184399_0_v_2_cnot1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SJXC-0426-SM-2XCFH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830369 FOXA1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_7_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PVOW-0726-SM-2XCF5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.01168 ZNF143 ENCODE Transcription Factor Targets 1.0 null NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.871899 Ca-Ski Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.14104 GSE169205_3_v_8_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null AA-22-UI44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.75386 BRD-K10590495 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47567 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles 1.0 1.12955 WHSC1 ENCODE Transcription Factor Targets 1.0 null GSE84922,GSE84924_0_v_1_sall4_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K74399971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03286 POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 BRD-K95792127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09749 Carcinoma, Ovarian Epithelial DisGeNET Gene-Disease Associations 1.0 null FF-86-NH56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.412695 AA-88-PJ86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.320135 GTEX-R55G-0926-SM-48FDN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12347 negative GeneRIF Biological Term Annotations 1.0 null BRD-K80414383 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00589 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-94-8491-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZBTB33_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 0.982091 H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K30433551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06536 POLR2A ENCODE Transcription Factor Targets 1.0 null RXRA::VDR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.2 GSE169691_1_v_2_saha_mouse RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JD-44-KF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.936004 H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHSE-0011-R3A-SM-3P5ZM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57876 JUN ENCODE Transcription Factor Targets 1.0 null CRCGN009_HEPG2_24H:A24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.18665 DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.11538 PMC9434001-Table_4.XLSX-Sheet1-ZBTB7B_ZBTB7B Rummagene Transcription Factor Associations 2026 1.0 null MHHES1 CCLE Cell Line Gene CNV Profiles -1.0 -1.71449 GSE127790_9_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null K562_Meprednisone_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0183839 ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null embryonic fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.463787 EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.830792 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null amygdaloid complex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.880953 OCILY3 CCLE Cell Line Gene Expression Profiles 1.0 1.93202 H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Adult Liver Carcinoma DisGeNET Gene-Disease Associations 1.0 null LUDLU1_LUNG CCLE Cell Line Proteomics 1.0 3.8851 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null BRD-K58070604 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24222 CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5X1-0001-SM-3P61V GTEx Tissue Sample Gene Expression Profiles 1.0 1.02051 OLIG2-29049317-MOUSE-SPINALCORD ChEA Transcription Factor Targets 2022 1.0 null organic substance metabolic process GO Biological Process Annotations 2015 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A183-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PWO3-0011-R1A-SM-2I5EW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.981954 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A194-01A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE199255,GSE199356_6_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null BRD-K16251850 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.7226 H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SPI1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null myotonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.581996 FUOV1 CCLE Cell Line Gene CNV Profiles 1.0 1.40067 GTEX-NL4W-0011-R4a-SM-2I5GZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77413 BT20 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.600397 GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2914 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JC-0011-R7A-SM-32PME GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08384 BRD-K65752097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.37073 Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12107 cognitive disorder GWASdb SNP-Disease Associations 1.0 0.093007 1774_COPG1_P1 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.82064 Mafg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.6527 H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Buccal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.908 striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.22035 decreased fertilization frequency MGI Mouse Phenotype Associations 2023 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K28140029 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0362 FF-28-ES17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.30532 hsa-miR-2355-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null glycerolipid biosynthetic process GO Biological Process Annotations 2015 1.0 null H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null 1544_CHAF1A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.508403 H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F6_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FPGS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73335 CRCGN013_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.017 hsa-miR-3661 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 primary motor cortex (area M1, area 4)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.888434 HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20589 H3K9ac_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-PX3G-0006-SM-33HBQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.84383 GTEX-X4EP-0326-SM-3P5Z6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.993612 H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWO3-0011-R2A-SM-2S1OX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.895188 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CEBPB ENCODE Transcription Factor Targets 1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08786 TBX20-22328084-HEART-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MHH-PREB-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null 10738_ZWINT_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.611326 GTEX-RTLS-0726-SM-46MV4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.945353 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158834_11_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null RB-34-TO07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.238129 GSE184884_2_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE160817_7_v_1_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A9WH-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_HEPG2_48H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.52422 GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles 1.0 1.88997 CRCGN015_MCF10A_48H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.6129 bonemarrow_6c HPA Tissue Sample Gene Expression Profiles 1.0 0.895636 Plantaris muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.595 QB-35-FO29_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.216548 H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.17657 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.391176 GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles 1.0 1.2993 GTEX-X4LF-1726-SM-3NMBZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.844709 melanocyte TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FOXA2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-49-MD69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.92004 GSE142210_3_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null ZMYM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43939 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20985 Lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE168797_1_v_5_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05474 NFYB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF1-21803131-MONOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null SIN3A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UACC893 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.17354 AB-30-CR11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.261243 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc_7Hour_None_GSE43204 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.26931 VD-88-MW70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.259514 TOP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74647 laminin-2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.651 ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null Cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 BRD-K86746660 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.94241 spinalcordlower BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.59461 Testicular cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CHD1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.0733 GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles 1.0 2.35499 GSE129389_0_v_4_tropifexor_mouse RummaGEO Drug Perturbation Signatures -1.0 null Gata-6_KO_GDS4782_330_mouse_Adult heart during pressure overload GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.753 NCIH1436 CCLE Cell Line Gene CNV Profiles -1.0 -1.49066 CRCGN010_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.12291 GSE182181_1_v_0_ricolinostat_human RummaGEO Drug Perturbation Signatures 1.0 null WC-09-GD62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.4796 BRD-K31526203 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20388 PDCD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02977 CW-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE158834_0_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null A549_Aurora A Inhibitor I_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0125594 GR MotifMap Predicted Transcription Factor Targets 1.0 null RPMI-7951 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00713 GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.911602 POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null endoplasmic reticulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.128396 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.96745 phosphatidylinositol-3-phosphatase activity GO Molecular Function Annotations 2015 1.0 null GSE148066,GSE157787_3_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE100316_5_v_6_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null 5637 COSMIC Cell Line Gene Mutation Profiles 1.0 null SKNAS CCLE Cell Line Gene CNV Profiles -1.0 -1.6883 GSE168797_1_v_0_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.251 PBX3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE126621,GSE126920_1_v_3_dppa4_mouse RummaGEO Gene Perturbation Signatures 1.0 null cytoplasm LOCATE Curated Protein Localization Annotations 1.0 null Centronuclear Myopathy DisGeNET Gene-Disease Associations 1.0 null GSE171177,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null FOXA1_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tibialis posterior TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.891 RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Familial combined hyperlipidaemia_lymphoblast_GSE1010 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.50341 GSK3A_knockdown_205_GDS4305 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.33109 inner CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.928224 GTEX-OXRO-0011-R9A-SM-3NB1X GTEx Tissue Sample Gene Expression Profiles -1.0 -2.32262 BRD-A84941884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39847 liver_a HPA Tissue Sample Gene Expression Profiles -1.0 -0.849642 GSE180321_0_v_1_imperatorin_human RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-FV-A495-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Polycystic Ovary Syndrome_Adipose tissue_GSE5090 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.35861 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-7332-01A-11R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell part LOCATE Curated Protein Localization Annotations 1.0 null NCI-H2342 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null phosphatidylinositol metabolic process GO Biological Process Annotations 2025 1.0 null ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K46119789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.18569 PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null BRD-K92974694 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67253 LI7 DepMap CRISPR Gene Dependency 1.0 3.81669 TF-77-DW08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21208 Esophagus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.003 GTEX-R53T-1226-SM-48FCT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02356 GSE208096_1_v_0_progesterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A.WT.HP_24H:D24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.60918 SNU1214 CCLE Cell Line Gene CNV Profiles -1.0 -1.55825 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE148066,GSE157787_8_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100395_TCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.03758 LMO2-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CB-49-OG36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.377593 BRD-K87290989 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40129 abnormal motor coordination/ balance MPO Gene-Phenotype Associations 1.0 null GSE124410_2_v_5_stk40_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN014_HEPG2_24H:K06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.29076 Proximal Muscle Weakness DisGeNET Gene-Phenotype Associations 1.0 null Heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.009 GSE126463_1_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null HC-74-HM63_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.473987 Autophagy - animal KEGG Pathways 2026 1.0 null Cystic Fibrosis_Intestinal Epithelium_GSE765 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -0.933998 Cvt vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.515 A549_AR-42_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00921781 RAB6D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95308 ZNF384 ENCODE Transcription Factor Targets 1.0 null GSE80098,GSE80366_0_v_6_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null 17533364-TableS3 GeneSigDB Published Gene Signatures 1.0 null abnormal heart morphology MPO Gene-Phenotype Associations 1.0 null GTEX-WZTO-0011-R6B-SM-4E3J6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88576 BCL6-25482012-CML-JURL-MK1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CREB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN008_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.26025 BRD-K37015376 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16152 PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-mouse_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.09585 GTEX-OHPM-1026-SM-3LK74 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23961 GTEX-XGQ4-0126-SM-4AT4H GTEx Tissue Sample Gene Expression Profiles 1.0 1.01266 9073_TMEM41B_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.535679 POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.63069 SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.26426 FOXA1-21915096-LNCAP-1F5-HUMAN ChEA Transcription Factor Targets 2022 1.0 null OE33 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.26997 BRD-K98441254 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13652 H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8046804-41467_2021_22478_MOESM11_ESM.xlsx-Del_AA-TCGA-Unnamed_38_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.125883 BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31686 pineal_day BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.996126 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lipid biosynthetic process GO Biological Process Annotations 2015 1.0 null enzymatic GeneRIF Biological Term Annotations 1.0 null TCF7L2-21901280-H4IIE-RAT ChEA Transcription Factor Targets 2022 1.0 null GSE167324_2_v_0_eif4e_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary motor cortex (area M1, area 4)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.917969 STAT3 MotifMap Predicted Transcription Factor Targets 1.0 null THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.3514 GSE181003_1_v_0_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H2126 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16726 BRD-K42650945 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76638 FA-88-II68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.1037 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE214505_0_v_1_akr1b1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211286_1_v_3_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null BC-10-SB73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.310969 K562_Anacardic Acid_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0180329 CRCGN010_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40705 USF1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.87245 GSE186647,GSE217288_1_v_4_hnrnpc_human RummaGEO Gene Perturbation Signatures 1.0 null GSE198165,GSE198166_5_v_11_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null Megaconial type congenital muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.041 BRD-K97934318 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07853 GSE48812_2_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GSE68155_3_v_2_gpr3_mouse RummaGEO Gene Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21458 GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SL-01A-21R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCFCP2L1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K13788250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06747 5637 CCLE Cell Line Gene Expression Profiles 1.0 3.39377 hsa-miR-657 TargetScan Predicted Conserved microRNA Targets 1.0 0.336728 Endomysium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.927 GSE159893_2_v_0_genistein_human RummaGEO Drug Perturbation Signatures -1.0 null BICR 22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66056 BRD-K57784254 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04752 GTEX-P4PQ-1626-SM-2HMKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.01256 Spontaneous Abortion DisGeNET Gene-Phenotype Associations 1.0 null YAP1 ChEA Transcription Factor Targets 1.0 null H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE152441,GSE152442_0_v_4_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE81193_3_v_5_irf3_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K78238858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27937 vomeralnasalorgan.VMO. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.03104 GTEX-R53T-0005-SM-3GADK GTEx Tissue Sample Gene Expression Profiles 1.0 1.13576 GSE240439_1_v_2_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE103297_1_v_0_glis3_mouse RummaGEO Gene Perturbation Signatures 1.0 null central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.831228 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE206400_3_v_4_nusinersen_mouse RummaGEO Drug Perturbation Signatures -1.0 null 5637 CCLE Cell Line Gene CNV Profiles 1.0 2.59998 KALS1 DepMap CRISPR Gene Dependency 1.0 2.9613 USF2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GAK Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.85768 BRD-K53168433 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01881 PMC6786946-NIHMS1535503-supplement-3.xlsx-SAT1_2_0x-FOXM1_genes_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-1005-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WAOSEL DepMap CRISPR Gene Dependency 1.0 2.00051 SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.47346 muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.11022 REST_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE118794_5_v_4_zmynd8_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.162 AKT1_knockout_210_GSE39699 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.37472 hippocampus (hippocampal formation)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.57454 BRD-K54003455 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08893 GSE148066,GSE157787_3_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FBXO27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00929 GTEX-TKQ2-0426-SM-4DXUO GTEx Tissue Sample Gene Expression Profiles -1.0 -2.09013 PMC11321995-41556_2024_1460_MOESM2_ESM.xlsx-Supplementary_Table_9-Supplementary_Table_9_Unique_genes_with_exons_significantly_correlated_with_OTX2_expression_in_Group_3_and_Group_4_MB_tumors_OTX2 Rummagene Transcription Factor Associations 2026 1.0 null Ruffle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 SKOV3 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.13926 H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skeletal muscle satellite cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.699 dorsolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05518 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YD-49-HM53_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.882046 BRD-K45282594 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03429 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.19391 HPAFII CCLE Cell Line Gene CNV Profiles 1.0 1.65329 Lung adenocarcinoma_LUAD_TCGA-69-8453-01A-12R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K44052748 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61597 SIX5 ENCODE Transcription Factor Targets 1.0 null Vastus lateralis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.035 BRD-K64075179 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00453 CAS1 DepMap CRISPR Gene Dependency 1.0 2.71577 cone-rod dystrophy 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.142 IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0056 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JL-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8851354-Table_5.xlsx-FUS-DDIT3_ruxo_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_both_FUS-DDIT3_and_ruxolitinib_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null GSE205316,GSE205317_2_v_3_nrip1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ITGB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23734 Perturb_9548_KO_Ucp1_SRP323371 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.65761 GTEX-UJHI-0006-SM-3DB8H GTEx Tissue Sample Gene Expression Profiles 1.0 4.54982 20174566-TableS1 GeneSigDB Published Gene Signatures 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LH-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K29760532 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54777 GTEX-WCDI-0005-SM-3NB2M GTEx Tissue Sample Gene Expression Profiles 1.0 1.80074 GTEX-WZTO-1126-SM-3NM93 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.993438 abnormality of nervous system physiology GWASdb SNP-Phenotype Associations 1.0 0.052824 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.44702 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.29279 teratozoospermia MGI Mouse Phenotype Associations 2023 1.0 null BRD-K68869896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33595 BB-79-AG41_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.227825 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K67902591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23894 Basal tubulobulbar complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.927 BRD-K74267000 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13255 GTEX-XXEK-0126-SM-4BRVU GTEx Tissue Sample Gene Expression Profiles 1.0 0.875717 PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT6 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-U3ZN-1826-SM-4DXUY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.850397 BRD-K36583698 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58816 K562_Raltitrexed_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0216324 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.165463 hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SLC45A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06316 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.12258 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null glycerophospholipid metabolic process GO Biological Process Annotations 2015 1.0 null H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33203 Phagophore COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.948 PBX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hypocotyl TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067477 BRD-K19645475 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.28932 ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.2511 GSE195582_3_v_1_pim1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE179974_3_v_4_carboplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null ZD-18-MI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.456607 HB-06-WU12_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.278402 CAL51 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.84192 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3WY-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RMUG-S TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.762 BRD-K22988729 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53462 Urinary system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K36198653 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06546 MDA MB435 BioGPS Cell Line Gene Expression Profiles 1.0 2.00356 BRD-K61491580 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70702 A549_Iniparib_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0126552 PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null A549_2-Methoxyestradiol_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0104602 H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y7-01A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MV-4-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.63683 GSE202434,GSE202438_13_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null NF-21-HQ00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.328946 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.199033 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HY-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KA-29-AB08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.444822 MRPL19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2825 A549_Ofloxacin_1然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.0114127 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_88_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null HES5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0899 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1331 GSE169205_0_v_1_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE128730_0_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K25718630 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21524 BRD-K19501975 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.16033 Synthesis of PIPs at the plasma membrane Reactome Pathways 2014 1.0 null GSE237426_0_v_1_eif4a1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null phosphatidylinositol-3,5-bisphosphate phosphatase activity GO Molecular Function Annotations 2023 1.0 null LinE complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.629 VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19103 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OPM2 DepMap CRISPR Gene Dependency 1.0 2.77931 autophagic vacuole COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.507163 plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054247 BRD-K29642620 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40157 PRKACA_knockout_266_GSE20984 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.56174 DISP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26805 primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.865584 SKMEL24 CCLE Cell Line Gene CNV Profiles -1.0 -1.32539 MCF7_TMP195_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0171 HEYA8 DepMap CRISPR Gene Dependency 1.0 2.67451 H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null rectum HPA Tissue Protein Expression Profiles 1.0 0.910487 TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-4593-11A-01R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE146982_3_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null VI Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.832823 GSE60837_6_v_3_bcl9_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE146982_3_v_6_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158834_11_v_4_palm_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K82433264 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00558 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JC-0226-SM-32PMA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10227 BRD-K25868508 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48349 GTEX-NL3H-0011-R2a-SM-2I3GG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48813 GSE240896,GSE240899_10_v_4_ccnt1_human RummaGEO Gene Perturbation Signatures 1.0 null skin TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null JHOS4 CCLE Cell Line Gene CNV Profiles 1.0 1.72055 HCC1143 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.597049 G140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.835758 AD-16-HL96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 3.15513 GTEX-REY6-1026-SM-2TF4Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.972889 NCIH23 Achilles Cell Line Gene Essentiality Profiles 1.0 1.3476 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.58315 ZBTB33 ENCODE Transcription Factor Targets 1.0 null GSE137144_4_v_0_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T5JW-0226-SM-4DM7I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04653 Liver Diseases CTD Gene-Disease Associations 1.0 1.07625 BCL3-23251550-MUSCLE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles 1.0 1.5559 primary auditory cortex (core)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.27278 CP in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16005 GTEX-R55G-0226-SM-48FEI GTEx Tissue Sample Gene Expression Profiles 1.0 0.857126 STAT5A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SISO Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.80257 BRD-K57497543 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.94478 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PCGF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49517 Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4437 TargetScan Predicted Conserved microRNA Targets 1.0 0.348832 Charcot-Marie-Tooth disease type 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.83 phosphatase GeneRIF Biological Term Annotations 1.0 null GC-04-UF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.60618 SKMM2 DepMap CRISPR Gene Dependency 1.0 5.56211 INSM1_KO_GDS5066_472_mouse_pituitary gland GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BE-79-QU25_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.543852 dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.03307 GSE126776_2_v_1_pelp1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QDVN-0326-SM-2I3FS GTEx Tissue Sample Gene Expression Profiles 1.0 0.932831 MCF7 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.08042 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null missense GeneRIF Biological Term Annotations 1.0 null GSE198165,GSE198166_6_v_11_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null SIG-M5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.66999 PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP2 ChEA Transcription Factor Targets 1.0 null SMC3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K97393725 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.87665 GSE199081_0_v_1_insr_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K80877725 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.25969 Vici syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.111 JARID1A-20064375-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null bewo HPA Cell Line Gene Expression Profiles 1.0 2.45878 BRD-K21841771 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.09957 A3-KAW Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.97379 dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.0501 NR2F2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ8I-1726-SM-4BOQB GTEx Tissue Sample Gene Expression Profiles 1.0 1.02611 MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K47599758 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38891 MAFA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.5472 H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null t-cell chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08447 SP1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null iPS-18 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.70895 BRD-K61354849 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63495 CRCGN015_HEPG2_48H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27805 BRD-A89441445 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05978 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE206516,GSE206518_6_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K43909206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4394 Foxj3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 37.3225 PEO1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.41018 USF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gastrointestinal cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BE-79-QU25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.43842 epidermal cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE89154_1_v_0_proscillaridin_human RummaGEO Drug Perturbation Signatures -1.0 null DC-51-WE27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.703273 BRD-K25942808 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01285 nizatidin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26971 ES-I3 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 2.11968 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cellular biosynthetic process GO Biological Process Annotations 2015 1.0 null POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05866 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-F5-6864-01A-11R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.292 PK59 CCLE Cell Line Gene CNV Profiles 1.0 1.53972 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE207863_0_v_1_hdac5_human RummaGEO Gene Perturbation Signatures 1.0 null BD-04-NG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.415933 Crus I, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01699 SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15314 CHD1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCRT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3501 CiliaryGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.23837 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UPK5-1426-SM-4JBHH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828614 RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7SE-0011-R5A-SM-2XCDA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.942263 H3K27ac_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K30566330 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23073 GSE148066,GSE157787_5_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-5489-11A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.12369 RUNX1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null LPS510 DepMap CRISPR Gene Dependency 1.0 2.18022 H3K23me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MZ in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.31997 BRD-K46641047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01613 testis TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 BRD-K43298189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75355 ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919801 Congenital myopathy 1B DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.345 orbital frontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.51593 GTEX-XMK1-0126-SM-4B65F GTEx Tissue Sample Gene Expression Profiles 1.0 1.09325 BRD-K42526449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04957 Semitendinosus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.943 GA-59-RW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249255 MCF7_PF-3845_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137598 16651409-SuppTable5 GeneSigDB Published Gene Signatures 1.0 null GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.24091 GSE148066,GSE157787_2_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Myosin filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.751 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null COPD - Chronic obstructive pulmonary disease_Lung Tissue_GSE1650 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.59327 ZBTB33_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_AZ 960_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0130981 phosphatase activity GO Molecular Function Annotations 2015 1.0 null H3K27ac_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SNAI3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8341 BRD-K76942055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29607 GTEX-R55D-1426-SM-48FEN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83122 BRD-K26472648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08333 GTEX-WL46-0011-R9A-SM-3MJFP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11587 GTEX-S4UY-0006-SM-3K2A7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.87276 CF-24-KQ98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.212745 organelle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.054194 UBC Pathway Commons Protein-Protein Interactions 1.0 null G-361 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-Q2AG-0011-R4A-SM-2HMKA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.888339 GSE210655_3_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null MCF7_Prednisone_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0128662 GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30543 GTEX-WH7G-0002-SM-4LVN9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.932942 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.62641 GTEX-TSE9-0011-R7A-SM-3DB7P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12056 TCF3/E2A-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null GTEX-X261-0011-R7A-SM-4E3JJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62247 GSE218356_1_v_0_cited1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MTDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00431 GTEX-QMR6-0011-R6A-SM-32PKP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.932387 GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.68167 Generalized Hypotonia DisGeNET Gene-Phenotype Associations 1.0 null NCI-H292 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.13574 PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K45472595 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03452 Kidney Chromophobe_KICH_TCGA-KN-8430-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null IPC-298 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null K562_NVP-BSK805 2HCl_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0131509 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K32722078 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53863 NFYB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.1815 BRD-K04877446 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04056 OTX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.563 GSE117042_1_v_3_tunicamycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null LCLC97TM1 DepMap CRISPR Gene Dependency 1.0 6.74496 BRD-K79555196 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77505 teratocarcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-T5JC-2526-SM-4DM6G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21204 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUM1315MO2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.699873 VI, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.4827 amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.15677 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:P14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.40357 PMC8851354-Table_5.xlsx-FUS-DDIT3_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_FUS-DDIT3_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TSE9-0011-R4A-SM-3DB7H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18833 GTEX-UTHO-0011-R2A-SM-3GIKC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16545 MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bethlem myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.286 MAFF ENCODE Transcription Factor Targets 1.0 null PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_Activation - 24 hours_GDS2025_726_mouse_Pancreatic islet beta cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null FOXM1 ENCODE Transcription Factor Targets 1.0 null POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149903_3_v_2_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.64478 GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles 1.0 0.970878 WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL3 ENCODE Transcription Factor Targets 1.0 null SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919801 H3K27ac_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K87082948 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.857 GTEX-T2IS-0426-SM-32QPE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13396 GSE130081,GSE130082_5_v_1_neil2_mouse RummaGEO Gene Perturbation Signatures 1.0 null protein tyrosine phosphatase activity GO Molecular Function Annotations 2015 1.0 null hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26102 binding GO Molecular Function Annotations 2015 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IA-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NRL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.542 Tonsil BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.871852 Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WC-16-IR43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.378826 MAFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1631 H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8432-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null E2F1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-PX3G-1026-SM-48TZW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73077 primary somatosensory cortex (area S1, areas 3,1,2)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.917825 AF-87-II41_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.252425 PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Unnamed_25_KLF10 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-UPK5-1626-SM-4JBHI GTEx Tissue Sample Gene Expression Profiles 1.0 0.828595 pi3p GeneRIF Biological Term Annotations 1.0 null GTEX-XLM4-0008-SM-4AT4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04398 Kidney - Cortex GTEx Tissue Gene Expression Profiles 2023 1.0 0.933681 phosphatidylinositol GeneRIF Biological Term Annotations 1.0 null ISTMEL1 DepMap CRISPR Gene Dependency 1.0 3.03413 ELF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.727 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO Molecular Function Annotations 2025 1.0 null GTEX-UTHO-0011-R5A-SM-3GIJD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43345 A549_Abexinostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0104055 K562_JQ1_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0124614 PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null AF4-26711339-SEM-HUMAN-BLOOD-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null GSE223540_0_v_3_anxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MCF7_PF-3845_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141375 GSE223908,GSE223909_1_v_6_serpinb3_human RummaGEO Gene Perturbation Signatures 1.0 null alitretinoin_homo sapiens_gpl6480_gse43090 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null IRF8-27001747-CHIP-SEQ-BMDM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null EOL1 DepMap CRISPR Gene Dependency 1.0 5.36936 PD-70-VS77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.741623 leaf TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068878 BRD-K51707293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56549 BRD-K91588908 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.8432 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5881-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal sperm principal piece morphology MGI Mouse Phenotype Associations 2023 1.0 null CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LC-12-VN85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.239365 BRD-K89110518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0687 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114992,GSE114993_7_v_11_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.902711 GSE112765,GSE112767_1_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null Leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MET_knockout_248_GDS3148 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.69139 Protein phosphatase 4 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.614 PB-09-OE00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.246298 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dactinomycin_homo sapiens_gpl7172_gse12459 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null DD-42-PC65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.631409 GSE103122_0_v_1_puromycin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K79me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE209533_0_v_1_disulfiram_human RummaGEO Drug Perturbation Signatures 1.0 null YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Inflammation CTD Gene-Disease Associations 1.0 1.0561 MCF7_Mercaptopurine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0163621 Lung squamous cell carcinoma_LUSC_TCGA-22-5491-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE167474_1_v_3_naa40_human RummaGEO Gene Perturbation Signatures -1.0 null SK-N-DZ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17198 BRD-K36445086 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10299 PD-70-VS77_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.512627 superpathway of inositol phosphate compounds HumanCyc Pathways 1.0 null GTEX-NPJ8-0011-R5a-SM-2HMJY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06893 H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WL46-0011-R7A-SM-3LK7X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02227 K562_Entinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0205938 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_1197_KO_Klf13_SRP302435 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.02985 MEWO cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.701 MARVELD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23216 HEY COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-RM2N-1926-SM-48FCU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.938586 K562_Pracinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0191443 Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A9DB-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K37283718 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28252 SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.345929 SNU8 DepMap CRISPR Gene Dependency 1.0 4.59947 JUND_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.836393 Pancreatic_Islets Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.16327 GSE193258,GSE193259_2_v_0_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null renal epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC6469946-aav1472_Data_file_S3.xlsx-PPARG_targets_UP_RNA-Seq_Diet-Supplemental_Table_3_PPARG_targets_up_regulated_in_dKO_vs_CONTROL_RNA-Seq_Diet_FDR_0_1_n_290_PPARG Rummagene Transcription Factor Associations 2026 1.0 null GTEX-T2IS-0011-R5A-SM-32QP4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35749 ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal heart morphology MGI Mouse Phenotype Associations 2023 1.0 null RT11284 DepMap CRISPR Gene Dependency 1.0 2.11327 macroautophagy GO Biological Process Annotations 2023 1.0 null BRD-K88282877 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27352 NCIH1694 CCLE Cell Line Gene CNV Profiles -1.0 -1.91999 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Dok TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.018 MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.5928 Genital Diseases, Female CTD Gene-Disease Associations 1.0 1.04538 Lung squamous cell carcinoma_LUSC_TCGA-66-2785-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K57472585 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41791 hairpin sperm flagellum MGI Mouse Phenotype Associations 2023 1.0 null AR ChEA Transcription Factor Targets 1.0 null CRCGN017_MCF10A.TP53.M_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.01989 PD-05-HV36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.544234 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CD33+_Myeloid BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.54907 FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null myotubularins GeneRIF Biological Term Annotations 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REH Achilles Cell Line Gene Essentiality Profiles -1.0 -1.10964 STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YD-49-HM53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.12143 COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919801 PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1694 CCLE Cell Line Gene Expression Profiles -1.0 -2.19545 E2F4_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.9393 5163_MPHOSPH10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.525071 GSE120413,GSE120447_0_v_2_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SC-965 (MDM2) NURSA Protein Complexes 1.0 null NFIC ENCODE Transcription Factor Targets 1.0 null P granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.718 H4K20me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.953276 POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE95386_0_v_1_trim24_human RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-6771-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Autophagosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.938 Ulcerative Colitis_Peripheral blood mononuclear cell_GSE3365 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.7433 A-CA-04-2009(H1N1)_6Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.80053 Congenital Structural Myopathy DisGeNET Gene-Disease Associations 1.0 null CPSF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29973 TrigeminalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.11564 GSE189941_1_v_2_kdm4c_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CC-68-YZ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.504874 GTEX-RWSA-0926-SM-47JXW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857058 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE102132_2_v_1_irf3_human RummaGEO Gene Perturbation Signatures 1.0 null mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27074 MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7782698-41467_2020_20367_MOESM9_ESM.xlsx-Student_s_t-test_BP1_ILK_GFP-Gene_names_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null Phosphatidylinositol 3-kinase complex, class II COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.521 GSE197257_0_v_1_gpd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Chimp_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null RELA_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Chimp_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Charcot-Marie-Tooth disease type 4J DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.499 SREBF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22266 AU565 COSMIC Cell Line Gene Mutation Profiles 1.0 null SZ in subgenual cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.014 NO11 DepMap CRISPR Gene Dependency 1.0 2.57913 GSE175787_8_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.73995 abnormal muscle physiology MGI Mouse Phenotype Associations 2023 1.0 null EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-0526-SM-2S1PW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53878 8433_SRSF3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.68787 H3K79me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-193a-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 CRCGN011_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.0779 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.19588 GTEX-WHSE-0011-R4A-SM-3P5ZN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35597 GTEX-NPJ7-0011-R4a-SM-2I3GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92075 DMS114_LUNG CCLE Cell Line Proteomics 1.0 2.10973 anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.28861 GTEX-WL46-0011-R6A-SM-3LK6X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.934307 muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.868368 Erythroleukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN013_HEPG2_24H:N13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.54134 inner CP in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.66291 GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles 1.0 1.26012 Brain_Hippocampus_Middle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.18532 Lung squamous cell carcinoma_LUSC_TCGA-63-6202-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5452-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OSC-19 COSMIC Cell Line Gene CNV Profiles 1.0 2.76305 ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA Rummagene Transcription Factor Associations 2026 1.0 null smooth muscle HPA Tissue Protein Expression Profiles 1.0 0.910487 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K37308886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52777 H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE148066,GSE157787_2_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-U3ZM-0002-SM-3NMDM GTEx Tissue Sample Gene Expression Profiles 1.0 1.19926 Adductor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.783 amygdaloid complex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.829462 Melanoma cell line TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 substantia nigra, reticular part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23122 skeletal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.938777 PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ENSG_LTF Rummagene Transcription Factor Associations 2026 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41R-01A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K06049932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52937 H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null LN319 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.32557 REST_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 888 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.42609 E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-0626-SM-2XCBG GTEx Tissue Sample Gene Expression Profiles 1.0 1.06278 NCI-H2228 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.893846 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.392686 BRD-K83898111 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49273 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SSBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71114 CRCGN017_MCF10A.WT.HP_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.3726 SK-N-FI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24908 head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K79me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.05819 Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41P-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Disulfiram_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0179278 macrophage BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.19657 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null Macroautophagy Reactome Pathways 2024 1.0 null GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles 1.0 1.05154 GTEX-PWO3-0011-R5A-SM-2I5EZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20261 GSE131649_6_v_9_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null Disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.153 GSE127790_10_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Buccal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.299 muscle phenotype MPO Gene-Phenotype Associations 1.0 null midbrain raphe nuclei Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14319 PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K50177531 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0881 Perturb_12961_KO_NMNAT1_SRP313669 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -13.1599 GSE168697_0_v_1_wdr6_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PML_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.32361 parasolitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.45069 BRD-K63859730 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50149 GSE158834_0_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null principal sensory nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.21105 POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Trichostatin A_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00951168 USF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WWYW-0011-R5A-SM-3NB3E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13389 PAX5_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K79347397 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.33598 BRD-K15591233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99908 CRCGN011_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2443 USF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ID4_KO_GDS4178_620_mouse_Splenic B cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CAL 27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.836554 Charcot-Marie-Tooth disease type 4B1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.916 PMC8047323-Table_3.xlsx-Venn_581_LPS_T24_vs_LPS_T0-GeneSymbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Centrally Nucleated Skeletal Muscle Fibers DisGeNET Gene-Phenotype Associations 1.0 null PD-70-VS77_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.276688 BC-25-VR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.38858 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D6-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular part LOCATE Curated Protein Localization Annotations 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles 1.0 1.17 abnormal sperm midpiece morphology MGI Mouse Phenotype Associations 2023 1.0 null dilated sarcoplasmic reticulum MGI Mouse Phenotype Associations 2023 1.0 null BRD-K51342021 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07568 Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A74V-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null U2-type catalytic step 1 spliceosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.042 Easy Fatigability DisGeNET Gene-Phenotype Associations 1.0 null GSE154577_7_v_10_plagl1_human RummaGEO Gene Perturbation Signatures -1.0 null bipolar affective disorder GWASdb SNP-Phenotype Associations 1.0 0.465095 TF-04-RX73_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.250331 MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K41334119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28741 YBX1_01_255 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61091 GSE126463_0_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null Blood cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me1_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8059 GSE179880_7_v_5_e2f4_mouse RummaGEO Gene Perturbation Signatures -1.0 null tonsil_8a1 HPA Tissue Sample Gene Expression Profiles 1.0 3.11468 GSE158834_11_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.882874 CAL33 CCLE Cell Line Gene Expression Profiles -1.0 -1.79741 USF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-51-4081-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE112860_0_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null SOX15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.9161 PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null G141 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.825079 NFATC1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OV7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30656 Disease of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.015 LC1F CCLE Cell Line Gene Expression Profiles -1.0 -1.66837 GTEX-WH7G-0826-SM-4LVMR GTEx Tissue Sample Gene Expression Profiles -1.0 -2.1604 GSE112761,GSE112767_2_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null golgi apparatus LOCATE Predicted Protein Localization Annotations 1.0 null MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ID-69-QF93_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.2921 GSE186707_1_v_0_hdac4_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K04877855 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03565 7751_SEC61A1_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.518601 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE154767_2_v_0_adam10_mouse RummaGEO Gene Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3IE-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN013_HEPG2_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11178 myotonic dystrophy type 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.596402 brain HPA Tissue Gene Expression Profiles -1.0 -0.996102 GTEX-T5JC-0011-R5A-SM-32PLK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7727 SPI1-22790984-ERYTHROLEUKEMIA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null impaired acrosome reaction MGI Mouse Phenotype Associations 2023 1.0 null posteroventral (inferior) parietal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.953276 huh-7 BioGPS Cell Line Gene Expression Profiles 1.0 1.16628 GTEX-RWS6-1126-SM-47JXC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49479 BRD-K59120074 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15202 H3K79me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HF-91-IU60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.260252 myopathy GeneRIF Biological Term Annotations 1.0 null H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null heart muscle HPA Tissue Protein Expression Profiles 1.0 0.910487 bonemarrow_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.63618 ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-A84816049 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14034 GSE76771_2_v_3_atf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RU1J-0006-SM-2TF6M GTEx Tissue Sample Gene Expression Profiles 1.0 2.24323 K562_Tozasertib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0148983 UBTF ENCODE Transcription Factor Targets 1.0 null COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.04944 Hemangioma DisGeNET Gene-Disease Associations 1.0 null GSE114992,GSE114993_8_v_5_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4712-11A-02R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE201309_1_v_6_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.40688 Lung adenocarcinoma_LUAD_TCGA-50-5045-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_REST_18959480 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.788 MCF7_JNJ-7706621_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0132577 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.41635 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158431_2_v_6_pioglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null BCL3 ChEA Transcription Factor Targets 1.0 null lymphnode_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.18144 primary auditory cortex (core)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.40796 LYL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.43137 USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-2226-SM-3TW8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33024 BRINP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85254 CRCGN012_HEPG2_24H:D24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.02236 BRD-K78003637 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03515 T-cell chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MCF7_Curcumin_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141252 impaired exercise endurance MPO Gene-Phenotype Associations 1.0 null RNF138 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.20336 PHF20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6575 Muscular atrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.524 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-06A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.11025 BRD-K94440323 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2339 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.5259 Lung adenocarcinoma_LUAD_TCGA-80-5611-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-38-4625-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K17060750 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32318 BRD-K00970182 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69804 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7058-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ampulla TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.602 Catalytic step 1 spliceosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.008 GSE128730_7_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02061 NCIH1385 CCLE Cell Line Gene CNV Profiles -1.0 -1.49738 primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.850637 BRD-K96288607 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.11661 GTEX-U8XE-1026-SM-4E3HM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38555 GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29854 Phosphatidylinositol signaling system KEGG Pathways 2026 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148066,GSE157787_8_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXM1-25889361-OE33-AND-U2OS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null A204 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.0933 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AN3 CA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.19481 BB-11-JI42_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.333318 K562_Tucidinostat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140739 TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09572 Sarcoma_SARC_TCGA-SG-A849-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K34808207 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77467 CRCGN017_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.89862 GSE223008_11_v_3_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null OV7 CCLE Cell Line Gene CNV Profiles 1.0 1.3879 GTEX-WEY5-1026-SM-4LMK9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886399 GTEX-XLM4-0011-R7A-SM-4AT5L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.825837 FOXM1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.WT.HP_24H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33941 TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RL CCLE Cell Line Gene Expression Profiles 1.0 1.44363 GSE193258,GSE193259_5_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Ramelteon_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0133822 A498 BioGPS Cell Line Gene Expression Profiles -1.0 -1.26975 BHLHE40_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN017_MCF10A.TP53.M_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.19257 dorsal lateral geniculate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18855 GSE137144_3_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Congenital muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.661 HCC1263 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919801 GSE210580_5_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8333-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null BRD-K95443593 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05688 GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles 1.0 1.12592 KA-29-AB08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.73095 GSE159049_1_v_0_sox2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE154767_2_v_5_adam10_mouse RummaGEO Gene Perturbation Signatures -1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.576999 PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1 Rummagene Transcription Factor Associations 2026 1.0 null Difficulty Walking DisGeNET Gene-Phenotype Associations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null 3291_GATA1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.521054 GTEX-TML8-0526-SM-32QOQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58273 COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0197 Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3Z7-01A-12R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal muscle relaxation MGI Mouse Phenotype Associations 2023 1.0 null GSE223008_11_v_8_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null internal segment of globus pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03849 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles 1.0 1.29592 CRCGN010_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3306 GSE148066,GSE157787_3_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null upper (rostral) rhombic lip_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.880993 GSE202587_1_v_0_xrn1_mouse RummaGEO Gene Perturbation Signatures -1.0 null IKZF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K89432538 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51225 SPI1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sarcoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.365477 GTEX-P4QR-0006-SM-2I5GN GTEx Tissue Sample Gene Expression Profiles 1.0 1.14829 Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null QE-18-WG07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.265282 Myopathy DisGeNET Gene-Phenotype Associations 1.0 null GTEX-X4XX-0011-R6B-SM-46MWP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962168 CCRF-SB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.97991 PA-75-VL17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.15737 EP300_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.1258 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PSDG-1526-SM-48TCY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17004 BRD-K58835676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10777 Autophagosome membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.285 K562_GSK-LSD1 2HCl_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0148205 GSE131649_4_v_9_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-A75409952_wortmannin_A549_6.0_h_10.0_um LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE141328_1_v_0_rock2_mouse RummaGEO Gene Perturbation Signatures 1.0 null WC-09-GD62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.31688 hsa-miR-152 TargetScan Predicted Conserved microRNA Targets 1.0 0.766596 BRD-K04192407 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.37418 H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE119564_2_v_3_zfp217_mouse RummaGEO Gene Perturbation Signatures -1.0 null BA-95-YU85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.51845 phosphoric ester hydrolase activity GO Molecular Function Annotations 2015 1.0 null KMS12BM CCLE Cell Line Gene Expression Profiles 1.0 1.60723 SUP-B15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.898476 EP300_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.886403 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FA-36-VA24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.364506 VSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.736 BRD-K03554945 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60517 YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CUX1 ENCODE Transcription Factor Targets 1.0 null USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LNZ308 Achilles Cell Line Gene Essentiality Profiles 1.0 2.0289 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.11519 FOXA1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ATF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7574 GTEX-WHSE-0011-R2A-SM-3P5ZL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11025 Sleepy Facial Expression DisGeNET Gene-Phenotype Associations 1.0 null GTEX-OXRO-0011-R10A-SM-2I5EH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75078 431_AQR_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.555861 GSE149903_4_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01152 Uterine Carcinosarcoma_UCS_TCGA-N5-A59F-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUW1-0005-SM-4BOQ7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13243 excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55E-0006-SM-2TC5G GTEx Tissue Sample Gene Expression Profiles 1.0 1.47925 GSE200352_5_v_3_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null autophagy GeneRIF Biological Term Annotations 1.0 null GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.850529 GTEX-QLQW-0326-SM-447A8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16499 spleen GTEx Tissue Gene Expression Profiles 1.0 1.39925 IRF4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.051258 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.855176 SRR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49665 SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFE2L2 ChEA Transcription Factor Targets 1.0 null KMS34 DepMap CRISPR Gene Dependency 1.0 3.55308 GSE165548_2_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10695615-medi-102-e36343-s001.docx-0-ARNT_ARNT Rummagene Transcription Factor Associations 2026 1.0 null GSE228413_2_v_1_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null Centronuclear myopathy X-linked DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.776 STK17B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08256 Tubulobulbar complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.772 BRD-K87080069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72734 GSE193258,GSE193259_2_v_8_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K13927197 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11021 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.75704 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5X1-0006-SM-3GIJZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.69719 GTEX-OOBK-1026-SM-48TC2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.97357 H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE228413_4_v_1_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null MB-46-BT89_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.40918 UF-27-HS98_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.476902 PMC10594727-13062_2023_428_MOESM14_ESM.xlsx-Sheet1-PPARD_PPARD Rummagene Transcription Factor Associations 2026 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04896 Autosomal dominant intellectual developmental disorder 23 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.763 Sartorius TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.224 GTEX-U8XE-1826-SM-4E3HV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.874185 I band COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.286 Brain Lower Grade Glioma_LGG_TCGA-HT-7478-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE240896,GSE240899_2_v_4_ccnt1_human RummaGEO Gene Perturbation Signatures 1.0 null Extensor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.282 Fatigue DisGeNET Gene-Phenotype Associations 1.0 null A549_Navitoclax_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0132963 PMC11166884-mmc4.xlsx-Table_S3-Table_S3_proinflammatory-EC2_comparison_between_WT_and_TG_TCF15 Rummagene Transcription Factor Associations 2026 1.0 null phospholipid biosynthetic process GO Biological Process Annotations 2015 1.0 null X-linked myopathy with excessive autophagy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.88 AC-84-QG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.490917 MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GSE131377_4_v_3_spocd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Peripheral nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.501 abnormal cardiovascular system physiology MPO Gene-Phenotype Associations 1.0 null HDAC1 ENCODE Transcription Factor Targets 1.0 null GSE158834_0_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20506 JF-62-LU77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.49054 KM12 COSMIC Cell Line Gene Mutation Profiles 1.0 null FOXA1 JASPAR Predicted Transcription Factor Targets 1.0 null ML-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.933246 GSE148066,GSE157787_9_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null fatigue MPO Gene-Phenotype Associations 1.0 null PMC11067031-pnas.2317690121.sd06.xlsx-gene_list_14_txt-Differentially_expressed_genes_between_PML_RARA_GFP_vs_C88A_PML_RARA_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA Rummagene Transcription Factor Associations 2026 1.0 null VIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.949717 IRF1-21803131-MONOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null X-linked recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.34 NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-0926-SM-3GAD1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16179 GTEX-NL4W-0011-R10A-SM-2I3DY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18861 GTEX-T8EM-0006-SM-3DB71 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14208 Physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.157 caudal subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.870547 posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.52426 abnormal muscle contractility MGI Mouse Phenotype Associations 2023 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S3XE-0526-SM-4AD4G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44907 BC-62-RZ55_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.385121 GTEX-PX3G-0926-SM-48U12 GTEx Tissue Sample Gene Expression Profiles 1.0 0.859374 WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.55814 GTEX-X261-0011-R8A-SM-4E3I5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.949013 496100402_FWM_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.06906 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null QE-00-EB96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.393304 BRD-K88658905 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61213 RBBP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04 TC-71 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.49382 BRD-K84401063 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48267 drofenine-7129 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null CCRF-CEM COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE130676_0_v_1_suds3_human RummaGEO Gene Perturbation Signatures 1.0 null GSE243683_0_v_1_s100a16_mouse RummaGEO Gene Perturbation Signatures 1.0 null SAOS2 BioGPS Cell Line Gene Expression Profiles -1.0 -1.51573 H2AFZ ENCODE Transcription Factor Targets 1.0 null CRCGN009_HEPG2_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.28505 GSE82032_3_v_1_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NPJ8-0011-R2a-SM-2TC6M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.972531 GSE241402_0_v_1_prmt5_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles 1.0 2.27422 GSE175787_11_v_0_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GSE148066,GSE157787_5_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K89277562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31086 1583_CHMP3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.28908 POLR2A_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Celecoxib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0249453 H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A5BI-01A-31R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null melanoma cell line TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K15478481 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06153 Perturb_248_KD_TPRX1/TPRX2/TPRXL_SRP361145 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.34294 ERF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.532 A549_Ellagic acid_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0193003 BRD-K08829593 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92763 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.66056 GSE186287_1_v_3_ufm1_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.12036 KNS81 CCLE Cell Line Gene CNV Profiles 1.0 1.51125 Inositol phosphate metabolism KEGG Pathways 2026 1.0 null POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K74676765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06633 GSE167956_1_v_0_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null GSE244072_4_v_6_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE146982_3_v_1_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K14255526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10246 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K68595406 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69498 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K29652917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43897 K562_Tubastatin A HCl_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0266975 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.05079 BRD-K91271834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36874 Adductor magnus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.127 GSE152432_5_v_2_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null HELA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.973399 Brain - Frontal Cortex (BA9) GTEx Tissue Gene Expression Profiles 2023 1.0 2.56721 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null pancreas HPA Tissue Gene Expression Profiles -1.0 -2.04646 placenta disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.504973 H3K4me1_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null E2F1-26619117-HEPATOCYTES-MOUSE-LIVER ChEA Transcription Factor Targets 2022 1.0 null outer CP in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.871033 GSE118794_2_v_4_zmynd8_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles 1.0 1.3872 GSE193258,GSE193259_9_v_0_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null OAW42 DepMap CRISPR Gene Dependency 1.0 2.64608 DBH_KO_GSE33906_53_mouse_heart (E10.5) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-NPJ8-0011-R1a-SM-33HCB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.93427 plant vessel TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.658678 GTEX-VJYA-0126-SM-4KL1P GTEx Tissue Sample Gene Expression Profiles 1.0 1.50599 GSE182179_2_v_3_kdsr_human RummaGEO Gene Perturbation Signatures 1.0 null SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.37426 GSE183413_1_v_2_ash1l_mouse RummaGEO Gene Perturbation Signatures 1.0 null ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_SRT1720 HCl_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0113542 primary visual cortex (striate cortex, area V1/17)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.886623 CC-04-WK34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.01884 Phospholipid metabolism Reactome Pathways 2014 1.0 null 8661_TAF1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.24507 Excretory gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Phosphatidylinositol 3-kinase complex, class I COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.082 TCF7L2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null phosphatidylinositol monophosphate phosphatase activity GO Molecular Function Annotations 2025 1.0 null BICR56 CCLE Cell Line Gene CNV Profiles -1.0 -1.36295 cellular lipid metabolic process GO Biological Process Annotations 2015 1.0 null CHD4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-548u TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 BRD-K52218664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07191 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Atherosclerosis_Hepatic Tissue_GSE363 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.71971 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EGR1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K43431234 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79311 BCL11A ENCODE Transcription Factor Targets 1.0 null BRD-K67661742 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08112 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null bone marrow HPA Tissue Gene Expression Profiles 1.0 1.05674 GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-7107-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-DX-A8BN-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Thiotepa_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146798 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K97373334 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.69611 Lung squamous cell carcinoma_LUSC_TCGA-39-5029-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K89264608 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.90785 HE-80-BQ08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.462043 REST_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K40367360 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52023 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null testicular cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null OBI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46556 K562_RG108_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0189784 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q734-0006-SM-2I3FJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.917049 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.61866 POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Paresis DisGeNET Gene-Phenotype Associations 1.0 null GSE198165,GSE198166_9_v_11_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K95709431 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18681 CHD4 ENCODE Transcription Factor Targets 1.0 null GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles 1.0 1.76123 GTEX-XQ3S-1226-SM-4BOPP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826402 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AG-0011-R8A-SM-2HMK5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841641 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GI-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K59957885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96777 EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null authors GeneRIF Biological Term Annotations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6088-11A-01R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.842967 BRD-K55171585 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43748 DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.952933 H3K79me2_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null GTEX-OOBJ-0326-SM-33HBO GTEx Tissue Sample Gene Expression Profiles 1.0 0.956674 FD-59-TC81_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.282227 gallbladder HPA Tissue Protein Expression Profiles 1.0 0.910487 PLC/PRF/5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.954479 microbody LOCATE Predicted Protein Localization Annotations 1.0 null dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.860881 LHX9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7315 GTEX-P4PP-1026-SM-3NM9O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.36949 WC-16-IR43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.30648 POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-0006-SM-33HBH GTEx Tissue Sample Gene Expression Profiles 1.0 2.01755 496100514_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.0443 neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.075502 Urinary Incontinence DisGeNET Gene-Phenotype Associations 1.0 null GSE254517_3_v_0_irf7_mouse RummaGEO Gene Perturbation Signatures 1.0 null TCF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBJ-0926-SM-48TDO GTEx Tissue Sample Gene Expression Profiles 1.0 0.910092 BRD-K42849858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1133 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XV7Q-0626-SM-4BRV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01163 GTEX-WHSE-0011-R8A-SM-3P5Z1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886996 decitabine_homo sapiens_gpl570_gse30985 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CAOV4 Achilles Cell Line Gene Essentiality Profiles 1.0 1.03763 GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles 1.0 1.25119 CLPSL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1665 BRD-K46162352 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26468 HOPS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.244 GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles 1.0 1.00263 BRD-K74694052 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35699 GSE142210_11_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null CD-13-QZ32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.402501 CRCGN015_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.66218 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RUSQ-1926-SM-2TF6K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07499 MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.56806 CI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.31747 GABPA_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE101537_4_v_2_neurog3_mouse RummaGEO Gene Perturbation Signatures 1.0 null HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.22063 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.31421 CE-96-GH46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.623079 increased muscle fatigability MGI Mouse Phenotype Associations 2023 1.0 null JD-81-YX02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.3697 MYOPATHY, CENTRONUCLEAR, 1 CTD Gene-Disease Associations 1.0 2.88009 K562_Bisindolylmaleimide IX_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0166751 Masseter TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.644 Ocular motility disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.549 H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-K45190659 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.36401 GSE162739_4_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MA-58-RR04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.214307 GTEX-PWOO-0626-SM-48TZH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831192 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE125219,GSE125221_4_v_0_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null cerebellar cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.74477 USF2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1143 CCLE Cell Line Gene CNV Profiles 1.0 1.77163 MICAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1484 SIN3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEG5-1226-SM-447AR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844336 ADRA2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11591 5748_NOP2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.659897 mediodorsal nucleus of thalamus_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08327 BRD-K35646839 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.00791 imatinib_homo sapiens_gpl96_gds3043 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-WFON-0126-SM-4LVM9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09 GSE126219_0_v_1_haloperidol_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null HCC70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.90431 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2777-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.045786 MB-49-LL22_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.906656 CRCGN011_HEPG2_24H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.7122 GSE231641_0_v_1_robo1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K54384984 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80465 CRCGN015_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.91495 GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles 1.0 1.37226 A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.22231 NB10 DepMap CRISPR Gene Dependency 1.0 2.24735 BRD-K28853245 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15448 SCC-25 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06096 ELK4 ENCODE Transcription Factor Targets 1.0 null POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRN-1726-SM-3NM9B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892523 GTEX-R55G-1126-SM-48FDG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.914712 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null EC-62-OE64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.356227 PMC10742386-pnas.2311372120.sd05.xlsx-GCM1_ST-Gene_Symbol_GCM1 Rummagene Transcription Factor Associations 2026 1.0 null Abnormality Of The Foot Musculature DisGeNET Gene-Phenotype Associations 1.0 null GTEX-OXRK-1826-SM-2HMJE GTEx Tissue Sample Gene Expression Profiles 1.0 0.828668 BRD-K91406875 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13026 NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03785 STAT5A ENCODE Transcription Factor Targets 1.0 null hsa-miR-135b TargetScan Predicted Conserved microRNA Targets 1.0 0.274552 OV-56 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.66162 FA-89-PW29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.20183 SREBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K48987279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80032 PMC6902611-40104_2019_400_MOESM2_ESM.ods-FA-SNA-Total_of_1_054_out_of_1_627_proteins_were_considered_for_analyses_65_SNAI1 Rummagene Transcription Factor Associations 2026 1.0 null 20418243-SuppTable1a GeneSigDB Published Gene Signatures 1.0 null GSE117042_0_v_3_tunicamycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.10934 SLC7A6OS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07991 primary auditory cortex (core)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.11662 BRD-K35491869 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12938 NR2F2 ENCODE Transcription Factor Targets 1.0 null BRD-K84060528 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14417 PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.18363 FOXA2 ENCODE Transcription Factor Targets 1.0 null GC-04-UF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.238096 GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles 1.0 1.3473 GK_KO_GDS2610_162_mouse_Brown adipose tissue GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ETV6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6385 GSE201309_5_v_7_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.419 BRD-K80439500 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0034 ATF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ3S-1026-SM-4BOPJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01968 BRD-K20600965 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09061 BC-40-TU13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.929353 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.37617 BRD-K36368568 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.09228 CRCGN015_MCF10A.TP53.M_24H:L09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2022 HDAC2 ENCODE Transcription Factor Targets 1.0 null RPL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06701 GTEX-XMK1-2526-SM-4B666 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.932824 GTEX-RUSQ-0326-SM-47JWS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38154 CRCGN015_MCF10A.WT.HP_24H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5038 GSE80446_2_v_1_anakinra_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles 1.0 1.31089 Cell leading edge COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 PMC5542661__F1 PFOCR Pathway Figure Associations 2024 1.0 null KA-81-AG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.19756 KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.55407 Autophagy Reactome Pathways 2024 1.0 null Gross Motor Development Delay DisGeNET Gene-Disease Associations 1.0 null phosphatidylinositol-3-phosphate phosphatase activity GO Molecular Function Annotations 2025 1.0 null NR1D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0275 VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16765 BRD-K64732418 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23758 GTEX-T6MN-0011-R7A-SM-32QP5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.876959 trovafloxacin_homo sapiens_gpl96_gse9166 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IN-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4433-01A-22R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEYA8 Achilles Cell Line Gene Essentiality Profiles 1.0 1.25864 BRD-A66164310 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29427 GTEX-WWYW-0011-R6A-SM-3NB3G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78416 LYL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.85816 GTEX-QV31-1626-SM-2S1QC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857456 BRD-K59185421 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03314 primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.60167 SMC3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K83125173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38507 HS294T_SKIN CCLE Cell Line Proteomics 1.0 2.26835 posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.80549 POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BJ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.763 RARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19646 BRD-K39223685 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35243 abnormal sperm head morphology MGI Mouse Phenotype Associations 2023 1.0 null GSE171837_3_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 S0-EE-WJKI_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.26692 BRD-K12571248 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18997 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13689 hippocampus (hippocampal formation)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.62575 BACH1 ENCODE Transcription Factor Targets 1.0 null Intercostal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.819 BB-86-BE39_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.24755 phosphatidylinositol biosynthetic process GO Biological Process Annotations 2025 1.0 null inner portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15893 JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K34024207 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1025 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K83898323 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26557 TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PBX3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML ENCODE Transcription Factor Targets 1.0 null protein serine/threonine phosphatase activity GO Molecular Function Annotations 2025 1.0 null ZNF136 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.8472 BRD-K76803075 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93405 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046918 BRD-K64055457 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16865 EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null MDAMB436 CCLE Cell Line Gene CNV Profiles 1.0 1.50469 cell leading edge COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Duchenne muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.189 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null MITF ChEA Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7728-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gluteal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.036 Vacuolar lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.176 SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.889725 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles 1.0 2.03576 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytisine-1766 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Foxj2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 35.2498 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K86855109 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30251 XRN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44942 pdx1_22135308_duodenum_lof_mouse_gpl1261_gds4348 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.01107 Flexor TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.44 Motor Delay DisGeNET Gene-Phenotype Associations 1.0 null BRD-K23593468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65696 POU2F2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN013_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66424 CDC23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29767 BRD-K50479239 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53309 J82_URINARY_TRACT CCLE Cell Line Proteomics 1.0 3.08439 HUP-T4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.927213 DOHH2 CCLE Cell Line Gene Expression Profiles 1.0 2.14039 GTEX-X585-0005-SM-46MV3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29478 Adductor longus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.381 496100329_FWM_probable Alzheimer's disease_TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.01778 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE133087_1_v_2_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null Ms TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.039 Obesity DisGeNET Gene-Disease Associations 1.0 null GSE237053_1_v_0_comt_human RummaGEO Gene Perturbation Signatures -1.0 null PBX3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null KIF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8261 GTEX-NL3H-0011-R5a-SM-2I3GB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89173 Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.32376 GTEX-Q734-0426-SM-48TZX GTEx Tissue Sample Gene Expression Profiles -1.0 -3.61478 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner CP in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.920739 perinuclear region of cytoplasm GO Cellular Component Annotations 2015 1.0 null Teratocarcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07345 FF-90-JK74_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.768035 GATA3_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cranial nerve disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.440914 FOXA1-27197147-CHIP-SEQ-ENDOMETRIOID-ADENOCARCINOMA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BON-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.93 BCL3-23251550-MUSCLE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Polyhydramnios DisGeNET Gene-Phenotype Associations 1.0 null NGLY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0713 MYC ENCODE Transcription Factor Targets 1.0 null increased body fat mass MGI Mouse Phenotype Associations 2023 1.0 null 11906190-Table1a-1 GeneSigDB Published Gene Signatures 1.0 null striatum_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31456 KLF4 ChEA Transcription Factor Targets 1.0 null GSE232631_0_v_2_brca2_mouse RummaGEO Gene Perturbation Signatures 1.0 null AtrioventricularNode BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.41295 GTEX-NPJ7-0011-R6a-SM-2I3G7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00095 GSE210580_4_v_12_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CD-05-PU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.60592 CCNT2 ENCODE Transcription Factor Targets 1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.051009 GSE128730_7_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null SLR25 Achilles Cell Line Gene Essentiality Profiles 1.0 1.68886 GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null posterior (caudal) superior temporal cortex (area 22c)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.901824 outer CP in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.892464 BRD-K20809650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21937 PRRX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8383 POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null phosphatidylinositol-3-phosphate phosphatase activity GO Molecular Function Annotations 2023 1.0 null 496100618_PCx_probable Alzheimer's disease_no TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.10994 cytosol GO Cellular Component Annotations 2015 1.0 null BRD-K62017257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23825 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE140651,GSE140653_2_v_1_med1_human RummaGEO Gene Perturbation Signatures 1.0 null outer SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05879 GSE127790_13_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null globus pallidus, internal segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.897528 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RA-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Atg1/ULK1 kinase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.742 vascular bundle TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.131087 Reflex, Abnormal CTD Gene-Disease Associations 1.0 1.30299 H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null lymphnode_4b HPA Tissue Sample Gene Expression Profiles 1.0 0.996597 GSE100464,GSE100465_1_v_3_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null KA-81-AG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.20282 muscular atrophy MGI Mouse Phenotype Associations 2023 1.0 null GSE115542_5_v_1_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K68060538 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03365 LYL1 ChEA Transcription Factor Targets 1.0 null GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 0.909031 GTEX-QDT8-0011-R1A-SM-32PKS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.920361 GSE128730_0_v_5_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE57871_1_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RU1J-0426-SM-46MUK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.906724 ChIP_JARID1A_20064375 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TGIF2LY JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.4035 GSE160246_0_v_7_cpeb4_mouse RummaGEO Gene Perturbation Signatures 1.0 null EBF1 ENCODE Transcription Factor Targets 1.0 null GTEX-QV31-0226-SM-447BO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54638 DV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null ABC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.852072 GTEX-QVJO-0011-R5A-SM-2S1QM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95407 GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles 1.0 1.50259 tonsil_8b1 HPA Tissue Sample Gene Expression Profiles 1.0 1.29343 protein serine/threonine phosphatase activity GO Molecular Function Annotations 2023 1.0 null CL-34 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE112860_0_v_8_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.WT.HP_24H:A20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.87431 SIX5_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.84796 GTEX-XMK1-0326-SM-4B652 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31444 hydrolase activity, acting on ester bonds GO Molecular Function Annotations 2015 1.0 null AE-39-DG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.641243 Protein-tyrosine phosphatase-like InterPro Predicted Protein Domain Annotations 1.0 null NF-kappaB MotifMap Predicted Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TG-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RFX5 ENCODE Transcription Factor Targets 1.0 null ML1 CCLE Cell Line Gene Expression Profiles -1.0 -1.51209 A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.05534 BRD-K32078195 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26903 GTEX-T6MN-0011-R5A-SM-32QPD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.879382 BRD-K30795375 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48088 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.56806 BRD-K57795803 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49394 GD-79-TW34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.364202 BRD-K83238251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43647 GSE103122_0_v_1_riok3_human RummaGEO Gene Perturbation Signatures -1.0 null E2F4_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null perinuclear region of cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 NUGC2 CCLE Cell Line Gene Expression Profiles 1.0 1.34819 macroautophagy GO Biological Process Annotations 2025 1.0 null GABP-19822575-HEPG2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Omegasome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.612 BA-84-TD72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.216869 BRD-K60578515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49232 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles 1.0 1.13665 Retinitis Pigmentosa_Retina_GSE128 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.44115 HOXA10_01_358 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.69645 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_19_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OXRN-0011-R10A-SM-2I5GC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01845 H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2A MotifMap Predicted Transcription Factor Targets 1.0 null asthenozoospermia MGI Mouse Phenotype Associations 2023 1.0 null stomach HPA Tissue Protein Expression Profiles 1.0 0.910487 piriform cortex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.18849 CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSG-0126-SM-4KL1X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4475 HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.902581 Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A59T-01A-21R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.872215 GTEX-T6MN-0002-SM-3NMAH GTEx Tissue Sample Gene Expression Profiles 1.0 1.13523 SCH DepMap CRISPR Gene Dependency 1.0 2.30291 NCI-H2023 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.05262 PMC8350019-mmc2.xlsx-DESeq2_Pten_vs_control_batch_LF-ensembl_LTF Rummagene Transcription Factor Associations 2026 1.0 null intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.80292 BRD-K61551681 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15736 H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K83300227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32411 K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1331 GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.93614 CRCGN015_MCF10A.TP53.M_24H:B22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.1067 PMC8851354-Table_5.xlsx-Ruxolitinib_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_ruxolitinib_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null EE-03-SG02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.361992 RBBP5 ENCODE Transcription Factor Targets 1.0 null primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17673 GSE205070_2_v_5_mertk_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4621-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal cardiac muscle contractility MGI Mouse Phenotype Associations 2023 1.0 null DF-84-RT50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.97185 KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.835779 PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_22-Supplementary_Table_22_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_Beat-AML_cohort_TET2 Rummagene Transcription Factor Associations 2026 1.0 null SISO COSMIC Cell Line Gene Mutation Profiles 1.0 null SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01842 496100438_PCx_possible Alzheimer's disease_no TBI_88_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.40149 BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.15164 H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158456_1_v_3_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K55581069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60243 Pyloric Stenosis DisGeNET Gene-Phenotype Associations 1.0 null 496100358_HIP_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.64799 FOXM1-23109430-U2OS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null primary auditory cortex (core)_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29523 Congenital myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.948 GSE130383_2_v_3_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-NL3H-0011-R10A-SM-2I3E9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18938 GSE114992,GSE114993_8_v_3_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_89_MITF Rummagene Transcription Factor Associations 2026 1.0 null Perturb_1615_KO_Actb_SRP056432 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.55634 BRD-K10545066 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13783 K562_Aurora A Inhibitor I_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0167023 GSE115363_3_v_5_esrrb_mouse RummaGEO Gene Perturbation Signatures 1.0 null Thin Rib DisGeNET Gene-Phenotype Associations 1.0 null CRCGN015_MCF10A.WT.HP_24H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3194 Foxo1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.3339 HDAC2_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.940582 NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K40738002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11781 NRF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VI, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.886103 Ebolavirus(EBOV)_6day_PBMCs_17725815_GSE8317 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.59959 GTEX-WHSE-0011-R6A-SM-3P5ZP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30969 abnormal cardiac muscle contractility MPO Gene-Phenotype Associations 1.0 null whole plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054265 Respiratory failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.011 CORL279 CCLE Cell Line Gene Expression Profiles -1.0 -1.78082 USF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.64313 reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MAX_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE103068_5_v_1_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE57871_11_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null F36P DepMap CRISPR Gene Dependency 1.0 4.74111 hydrolase activity GO Molecular Function Annotations 2015 1.0 null HT1197 DepMap CRISPR Gene Dependency 1.0 2.67463 embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.92454 SETDB1 ENCODE Transcription Factor Targets 1.0 null KLF4-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SOHLH2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.7023 MCF7_Quisinostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00689204 Rectum adenocarcinoma_READ_TCGA-DY-A1DG-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PF-382 COSMIC Cell Line Gene Mutation Profiles 1.0 null HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.44513 Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles 1.0 1.45555 TCF12_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bronchopulmonary dysplasia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.086 CAL62 CCLE Cell Line Gene CNV Profiles 1.0 1.72164 NCIH1339 CCLE Cell Line Gene CNV Profiles 1.0 1.43429 Urogenital Abnormalities CTD Gene-Disease Associations 1.0 1.26329 ACTL6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81889 peptidyl-tyrosine dephosphorylation GO Biological Process Annotations 2015 1.0 null GTEX-VUSG-0006-SM-3GIK9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19132 COLO783 Achilles Cell Line Gene Essentiality Profiles 1.0 1.05418 cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07603 SUM 149PT Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.82675 BRD-K30491662 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31347 GSE203158_1_v_15_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null 8154_SMARCE1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.74653 H3K79me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Divalproex Sodium_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0261741 dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.3449 MDST8 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.105 Daytime sleep phenotypes GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.6 BRD-K77940693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04033 CRCGN009_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04496 MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1 ENCODE Transcription Factor Targets 1.0 null H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MDAMB231 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.678318 BRD-K32000549 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12007 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5333-01A-01R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null TB-06-VB30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.207672 H3K79me2_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC10961392__F2 PFOCR Pathway Figure Associations 2024 1.0 null CRCGN017_MCF10A.TP53.M_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4451 GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles 1.0 0.87518 MCF7_Zileuton_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0170722 USF MotifMap Predicted Transcription Factor Targets 1.0 null NCIH209 CCLE Cell Line Gene CNV Profiles -1.0 -1.89219 BRD-K89232006 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00442 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.894562 hsa-miR-3611 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GSE202434,GSE202438_13_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null t30-blood-rna_consensus MoTrPAC Rat Endurance Exercise Training 1.0 3.08715 tobacco use disorder GAD Gene-Disease Associations 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.777 7515_RPS26_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.561329 NFYA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE179974_3_v_2_carboplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE195559_2_v_4_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null R-atenolol-4841 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null integument TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles 1.0 1.48678 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CREB1 ENCODE Transcription Factor Targets 1.0 null GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.873913 TCCSUP_URINARY_TRACT CCLE Cell Line Proteomics 1.0 3.46215 primary motor cortex (area M1, area 4)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.86621 GSE171311_0_v_1_ellagic acid_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neuropathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.629 BHLHE40_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE114992,GSE114993_7_v_10_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 9747_VPS28_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.613241 H3K9ac_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE162739_7_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE179002_0_v_7_caprin1_mouse RummaGEO Gene Perturbation Signatures -1.0 null TBP ENCODE Transcription Factor Targets 1.0 null PK-59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.932704 Brain Lower Grade Glioma_LGG_TCGA-HT-A61B-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE112763,GSE112767_4_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCIH1963 CCLE Cell Line Gene CNV Profiles -1.0 -1.35544 lateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.51212 PMC8047323-Table_1.xlsx-FC_LPS_T24_Vs_LPS_T0_P_0_05_FC-GeneSymbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null impaired skeletal muscle contractility MPO Gene-Phenotype Associations 1.0 null GSE160246_0_v_5_cpeb4_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YF-00-IN39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.472376 TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.56286 MCF7_Costunolide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142575 Lung adenocarcinoma_LUAD_TCGA-97-8176-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null BRD-K96637326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51112 CRCGN015_MCF10A.TP53.M_24H:D17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.386 A-CA-04-2009(H1N1)_12Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.52706 GSE203308_4_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null cell projection GO Cellular Component Annotations 2015 1.0 null K562_TGX-221_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0178286 K562_Fasudil_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0239152 PI Metabolism Reactome Pathways 2024 1.0 null FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE175787_11_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null Water vascular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.599 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SP4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease of mental health GWASdb SNP-Disease Associations 1.0 0.041942 H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40912 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KYSE-510 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.36211 GSE233679_12_v_10_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OHPM-1626-SM-2HMK4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.981405 abnormal muscle relaxation MPO Gene-Phenotype Associations 1.0 null C32 Achilles Cell Line Gene Essentiality Profiles 1.0 2.27274 DMS454 CCLE Cell Line Gene CNV Profiles -1.0 -2.30175 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN010_HEPG2_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.87904 ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16191 CHP134 DepMap CRISPR Gene Dependency 1.0 3.64422 CAL-51 COSMIC Cell Line Gene Mutation Profiles 1.0 null NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles 1.0 1.12083 CCDC96 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0272 TJP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.011 SC-25-HE80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.342044 PMC5527282-ncomms16041-s3.xlsx-M_LPS_-_gene_signature-Supplementary_Data_2_Full_gene_list_of_M_LPS_-_signatures_as_defined_in_figure_3_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null PUM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18775 CHD1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37432 BRD-K28122619 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33864 abnormal muscle physiology MPO Gene-Phenotype Associations 1.0 null Sarcoma_SARC_TCGA-DX-A8BP-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135030_11_v_1_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null 496100616_FWM_no dementia_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.21268 HCC70 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.771935 K562_Triamcinolone Acetonide_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0184589 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ELF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K07361992 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43292 A549_GSK J1_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0200584 PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null SP2 ENCODE Transcription Factor Targets 1.0 null GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles 1.0 1.21539 Atrophy CTD Gene-Disease Associations 1.0 1.13793 ChIP_KLF4_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K76628294 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10096 BRD-K60127720 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18882 POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF85 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.286 BRD-K65729622 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22124 GSE131377_4_v_2_spocd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12325 Cervical carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.385509 LB2241-RCC Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.99106 CPSF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39563 CHD2 ENCODE Transcription Factor Targets 1.0 null cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BRD-K71472853 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74147 SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.7249 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.84796 DETROIT 562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.962372 BRD-K87654551 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33158 EP300_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ovary epithelium cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.646 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SP1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.88765 GATA3_01_163 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 9.26806 7477_RPL7A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.765859 IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1319 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.07824 nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 17638893-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null connective tissue TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052714 Renal epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K01285236 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01192 GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles 1.0 1.08795 FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE213588_9_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null small intestine HPA Tissue Protein Expression Profiles 1.0 3.27095 GABP-17652178-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE148066,GSE157787_0_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X88G-0006-SM-47JX5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.43343 olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.57836 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null phosphorus metabolic process GO Biological Process Annotations 2015 1.0 null Calf Muscle Hypertrophy DisGeNET Gene-Phenotype Associations 1.0 null Proximal Muscle Weakness In Lower Limbs DisGeNET Gene-Phenotype Associations 1.0 null PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_unique_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null MAFA MotifMap Predicted Transcription Factor Targets 1.0 null Epithelium TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K71499752 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11741 BRD-K25931705 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1366 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.006 ocular motility disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.77207 GSE142210_4_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE146156_1_v_3_tagap_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE93124_0_v_1_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FA-80-DR66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.376105 GSE148066,GSE157787_5_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K94196749 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.9408 BEN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.4038 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null USF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMS-79 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.41255 POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BLOC1S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4907 orbital frontal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.179 GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles 1.0 1.91223 H2595 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K84362145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20452 GSE148200_3_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null melanoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null outer CP in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09639 KB-46-EJ60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.83969 BRD-K70200818 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5391 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15978 7515_RPS26_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.627363 GSE171837_3_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H2BK12ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PRPF6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55648 A204 BioGPS Cell Line Gene Expression Profiles -1.0 -1.06542 BRD-K25645002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26279 Vascular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.032 IM-95 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.23794 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35795 Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.988203 GSE135030_11_v_6_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null SIGM5 CCLE Cell Line Gene Expression Profiles 1.0 1.79856 Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HL-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null SRF_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.38 COLO 849 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062443 FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral hypothalamic area, mammillary region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.903077 rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.6189 Ophthalmoplegia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.721 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17426 G292CLONEA141B1 CCLE Cell Line Gene CNV Profiles 1.0 1.44688 GSE157036,GSE166411_3_v_1_halofuginone_human RummaGEO Drug Perturbation Signatures 1.0 null organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041193 BRD-K57821544 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20178 BRD-K72770355 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69317 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_3_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null NCIH1092 CCLE Cell Line Gene Expression Profiles -1.0 -1.8588 H2BK12ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDAMB361 DepMap CRISPR Gene Dependency 1.0 4.81006 GSE128240_0_v_1_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null inner CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.876821 USF1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-5670-01A-21R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.TP53.M_24H:H22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.25975 EMG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04393 NELFE ENCODE Transcription Factor Targets 1.0 null SNU387 CCLE Cell Line Gene CNV Profiles 1.0 1.98119 Autosomal Dominant Myotubular Myopathy DisGeNET Gene-Disease Associations 1.0 null A204 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.51953 BRD-K66735566 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36809 H3K9ac_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE207611,GSE207612_3_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2856-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.48459 BRD-A77941182 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11274 GSE173262_2_v_0_ash1l_mouse RummaGEO Gene Perturbation Signatures -1.0 null MT-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE146982_3_v_6_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-5471-11A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KMS28BM CCLE Cell Line Gene CNV Profiles -1.0 -1.36387 BRD-K90519599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18233 EE-03-SG02_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.509743 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03785 Centronuclear myopathy 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.293 GTEX-T6MN-0011-R9A-SM-32QOZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59218 SIG-M5 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.17619 Perturb_17356_KO_Mir22_SRP216410 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.99145 LS 174T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null CPCN CCLE Cell Line Gene CNV Profiles -1.0 -1.59952 cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.13199 BRD-K61772027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05828 GSE216757_4_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B5-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ2-1226-SM-4DXSV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.85028 MDAMB415 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.17647 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LB-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null brain_3c HPA Tissue Sample Gene Expression Profiles -1.0 -0.893159 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE205729,GSE205731_2_v_1_tazemetostat_human RummaGEO Drug Perturbation Signatures 1.0 null SUM149PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.93372 POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K18856772 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89835 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.67912 NRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null reticular nucleus of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.991832 sclc21h HPA Cell Line Gene Expression Profiles -1.0 -1.30826 PRORP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11453 GSE223008_0_v_8_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE179031_3_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null cerebellar vermis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.88239 H3K79me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ISL1-27105846-CHIP-SEQ-CPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HCC2935 CCLE Cell Line Gene CNV Profiles -1.0 -1.40914 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5468-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9904760-elife-79363-supp2.xlsx-MDS1-Gene_MECOM Rummagene Transcription Factor Associations 2026 1.0 null NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.42694 WASF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84202 GTEX-WWYW-0011-R1A-SM-3TW8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5251 GSE216273,GSE216292_0_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN017_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.00295 cytosol COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 ptdins3p GeneRIF Biological Term Annotations 1.0 null LMO2-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Secondary lysosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.706 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Charcot-Marie-Tooth disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.857 BRD-K72866723 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83192 PMC8173714-NIHMS1678410-supplement-Supplementary_Table_2.xls-OfficialIPEXsig-Supplementary_Table_2_-_IPEX_signature_genes_with_their_average_IPEX_HD_fold_change_in_Tregs_and_Tconvs_FOXP3 Rummagene Transcription Factor Associations 2026 1.0 null Muscle Fiber Predominance DisGeNET Gene-Phenotype Associations 1.0 null GTEX-U4B1-0526-SM-4DXTK GTEx Tissue Sample Gene Expression Profiles 1.0 1.24553 GTEX-NPJ8-2126-SM-3MJGK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970107 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 16651409-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null K562_Resminostat_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0144462 mcf7 HPA Cell Line Gene Expression Profiles 1.0 1.05885 HDAC2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K42943023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67211 H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11651170-pt4c00533_si_002.pdf-67-SIX5_SIX5 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles 1.0 0.96185 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.01288 K562_Gandotinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0330247 H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6209 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K80819226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58964 RIGI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6347 Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.45093 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5457-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_MK-0752_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0210954 GSE128730_3_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE122101,GSE122103_3_v_4_ssu72_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_Ellagic acid_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.024047 NOTO JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.9936 H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null brain GTEx Tissue Gene Expression Profiles -1.0 -0.919983 VCAP Achilles Cell Line Gene Essentiality Profiles -1.0 -2.13745 BRD-K64811593 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2041 CRCGN011_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0206 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-0726-SM-4DXUA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01636 H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null substantia innominata, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.930137 A549_Danusertib_100nM_72h Sci-Plex Drug Perturbation Signatures 1.0 0.00986761 H3K79me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.919801 AD-16-HL96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.32922 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EJ-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A-CA-04-2009(H1N1)_7Hour_None_GSE37571 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.81693 SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null estradiol_mus musculus_gpl4134_gse23241 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null bonemarrow_6a HPA Tissue Sample Gene Expression Profiles 1.0 1.02911 MDST8 COSMIC Cell Line Gene Mutation Profiles 1.0 null EP300_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K22694513 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71894 EA-18-FP00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.209116 BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K49745983 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40024 Scoliosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.224 GSE186483_6_v_4_lrrk2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-TMMY-1326-SM-4DXU9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41134 ZBTB7A ENCODE Transcription Factor Targets 1.0 null Membrane fusion priming complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.852 CRCGN017_MCF10A.TP53.M_24H:L19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.42335 IRF1 ENCODE Transcription Factor Targets 1.0 null K562_Cimetidine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0214948 FOXP2_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DMS454 CCLE Cell Line Gene Expression Profiles -1.0 -3.23422 methotrexate-2041 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 1952_CTSS_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.579166 substantia innominata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01022 EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHSE-0011-R7A-SM-3P5YZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2796 Brain Lower Grade Glioma_LGG_TCGA-FG-5963-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_TMP195_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0168117 496100467_FWM_probable Alzheimer's disease_no TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.23943 PPP1R3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46846 TMEM268 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05904 subiculum, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14972 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.3756 SRF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZBTB33_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QV31-0126-SM-447BP GTEx Tissue Sample Gene Expression Profiles 1.0 1.26686 H3K27ac_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K69536411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07585 cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null 7251_RFFL_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.561364 liver_d HPA Tissue Sample Gene Expression Profiles -1.0 -0.981061 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null BE-81-QL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.377395 EP300_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211126_1_v_0_hapln1_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC38 CCLE Cell Line Gene CNV Profiles 1.0 2.14323 MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K26786741 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07697 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SPI1-22096565-GC-B-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null abnormal muscle contractility MPO Gene-Phenotype Associations 1.0 null GT3TKB COSMIC Cell Line Gene CNV Profiles 1.0 2.76305 respiratory failure DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.23945 ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.31549 H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TCFAP2C-20176728-TROPHOBLAST STEM CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -3.2956 MZ in midcingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14798 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.45321 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K20me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null BRD-K87808996 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55466 JARID1B-DAIN-22020125-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE90710_1_v_0_med13_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE154577_7_v_12_plagl1_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_HEPG2_48H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.61515 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A5-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K48092898 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48499 BRD-K32960568 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01246 BRD-K86867503 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.17293 K562_Costunolide_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0179902 Brain Lower Grade Glioma_LGG_TCGA-P5-A77W-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.62661 FE-10-KQ78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.416043 MCF7_Streptozotocin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157407 Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.559 GSE171179,GSE171181_0_v_1_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null AC-74-ZA35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.2159 RUNX2-24655370-MC3T3E1-MOUSE-BONE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.82438 19218430-TableS3 GeneSigDB Published Gene Signatures 1.0 null BRD-K31010207 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11407 NANOG_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_SNS-314 Mesylate_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0113775 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Q-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.WT.HP_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.73814 patient GeneRIF Biological Term Annotations 1.0 null BRD-K46293468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70559 Autolysosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.79 H3K4me1_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Myopathy DisGeNET Gene-Disease Associations 1.0 null BRD-K29636267 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32456 FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL3H-0011-R7a-SM-2I3G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.26933 CRCGN010_HEPG2_24H:B23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.05488 BRCA1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE112763,GSE112767_0_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null cisplatin_mus musculus_gpl339_gds3099 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K16231990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01016 GTEX-U4B1-0006-SM-3DB8E GTEx Tissue Sample Gene Expression Profiles 1.0 1.94934 BRD-K83949633 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42451 FF-86-NH56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.369178 TP63 JASPAR Predicted Transcription Factor Targets 1.0 null Congenital myopathy 1A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.404 abnormal exercise endurance MPO Gene-Phenotype Associations 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ELF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autosomal recessive centronuclear myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.981 EGR1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:A14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.73015 GTEX-UJMC-0526-SM-3GAE3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14553 Lung adenocarcinoma_LUAD_TCGA-91-6829-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147613_1_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 VA-92-QP54_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.242537 Dorsal fin TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.622 GTEX-XAJ8-0126-SM-47JYG GTEx Tissue Sample Gene Expression Profiles 1.0 1.11649 SNU201 DepMap CRISPR Gene Dependency 1.0 2.99713 GSE211126_3_v_4_hapln1_mouse RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.871168 CRCGN016_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.98942 SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11909 male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-608 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.617561 hsa-miR-3119 TargetScan Predicted Conserved microRNA Targets 1.0 0.199275 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.20821 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.68563 H3K9ac_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8346-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.55865 K562_Altretamine_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0247079 GSE167474_2_v_3_naa40_human RummaGEO Gene Perturbation Signatures -1.0 null Mesothelioma_MESO_TCGA-LK-A4O7-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null FEZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3419 Learning Disorders CTD Gene-Disease Associations 1.0 1.30696 upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.931571 NCIH441_LUNG CCLE Cell Line Proteomics 1.0 4.44304 BRD-K36852613 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16542 BRD-K67478255 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38243 BRD-K50976856 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09461 Lung squamous cell carcinoma_LUSC_TCGA-52-7809-01A-21R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U8XE-0005-SM-3DB8I GTEx Tissue Sample Gene Expression Profiles 1.0 1.33657 BRD-K13564884 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0458 H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QDVN-0526-SM-48TZ4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08901 anterior (rostral) cingulate (medial prefrontal) cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.929794 Perturb_2892_KO_Crls1_SRP132399 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 5888_NUP155_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.548689 ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.11049 PGA1 DepMap CRISPR Gene Dependency 1.0 6.23884 PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null POU2F2_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A3LU-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K94647035 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11928 GSE137144_2_v_0_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K05137000 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6333 GSE139239_2_v_6_ddr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RTLS-1326-SM-46MUN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.922328 GSE235587_2_v_0_mitoxantrone_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN012_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27422 skin cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.70713 primary metabolic process GO Biological Process Annotations 2015 1.0 null GSE158834_11_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-NL4W-0011-R6a-SM-2I3GA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55185 BRD-K49051633 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.53371 H3ac_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AA-23-FM46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.283409 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.10568 vacuole COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.081129 K562_Resveratrol_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157237 inner CP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.863601 GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 0.877997 RXRA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K80766355 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14533 A361 BioGPS Cell Line Gene Expression Profiles 1.0 0.857836 CRCGN015_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.84827 SARS-CoV_48Hour_20090954_GSE17400 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.60186 PMC10248509-Data_Sheet_6.CSV--Autophagy_AND_GSE58294_DE-genes_NOT_GSE66724_DE-Genes_NOT_GSE22255_DE-Genes_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null impaired fertilization MGI Mouse Phenotype Associations 2023 1.0 null H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null decreased testis weight MGI Mouse Phenotype Associations 2023 1.0 null POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158456_2_v_3_furin_mouse RummaGEO Drug Perturbation Signatures 1.0 null STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SIU7-0226-SM-4BRX2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.99107 TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.34228 CE-96-GH46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.721612 PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE240027,GSE240030_1_v_3_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JC-0011-R4A-SM-32PLT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27544 primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.54028 TBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7494 GE-53-SM76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.388063 TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV NSP16_Day7_None_GSE49263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.81951 FOXP1-21924763-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ5-0006-SM-2S1NZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.72391 GTEX-O5YT-0926-SM-48TDG GTEx Tissue Sample Gene Expression Profiles 1.0 0.939342 AA-58-FJ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.404425 BRD-K64571715 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68402 HC-74-HM63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.905342 BRD-K29969800 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.22657 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53225 MD-86-UW46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.236759 BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WE-43-PZ45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.207836 7141_RBBP5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.546778 H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_TGX-221_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0156051 MDS-L cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.56 salivarygland_6b HPA Tissue Sample Gene Expression Profiles -1.0 -1.45233 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TU-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cervical carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null 8656_TAF1A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.50777 H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K78363521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.58274 PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4 Rummagene Transcription Factor Associations 2026 1.0 null 6558_POLR3D_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.21244 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K27476515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21791 GSE145628,GSE145629_1_v_0_myrf_human RummaGEO Gene Perturbation Signatures 1.0 null prostate_4c HPA Tissue Sample Gene Expression Profiles -1.0 -1.00585 BRD-K10301055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89393 K562_Dacinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0152477 reuniens nucleus (medioventral nucleus) of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19577 GTEX-QLQW-0126-SM-447BK GTEx Tissue Sample Gene Expression Profiles 1.0 1.16222 IPC-298 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null FOXA1_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14959 Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09664 TFAP2C ChEA Transcription Factor Targets 1.0 null DES_KO_GDS4804_171_mouse_young skeletal muscles GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_2_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null GSE111881_0_v_1_znf768_human RummaGEO Gene Perturbation Signatures 1.0 null SPI1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K60272064 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16847 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KU812 DepMap CRISPR Gene Dependency 1.0 5.01593 BRD-K97595801 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32797 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FD-91-OK66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.38288 PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null ZNF728 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37785 FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null BRD-K25226763 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35655 Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.25298 GTEX-OIZH-0926-SM-48TBR GTEx Tissue Sample Gene Expression Profiles 1.0 0.912306 GSE179002_4_v_7_caprin1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1957 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TE1 CCLE Cell Line Gene CNV Profiles 1.0 1.33943 Lung adenocarcinoma_LUAD_TCGA-55-7281-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RM2N-1626-SM-2TF5N GTEx Tissue Sample Gene Expression Profiles 1.0 0.874736 biosynthetic process GO Biological Process Annotations 2015 1.0 null H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE168797_4_v_0_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP2 ENCODE Transcription Factor Targets 1.0 null GTEX-T8EM-1326-SM-3DB7G GTEx Tissue Sample Gene Expression Profiles 1.0 0.991275 BRD-K15931098 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.98344 BCL11A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K01142063 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21939 ophthalmoplegia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.935799 Perinuclear region of cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GTEX-NPJ8-0011-R8a-SM-2HMLG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15904 BRD-K80945184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08824 CB-16-SY72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.91516 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K00882360 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01094 CRCGN011_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8302 RI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.07139 GTEX-OIZH-1826-SM-2YUNP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06172 ETS1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null LOUNH91 DepMap CRISPR Gene Dependency 1.0 2.52236 BRD-K19142902 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23035 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.174 BD-38-QC39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.334366 CF-87-AS90_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232574 pyramidal cells of caudal CA4 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.905522 RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K85532500 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3712 HC-74-HM63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.86043 SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K59232896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2313 POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Z8-0226-SM-4AD5K GTEx Tissue Sample Gene Expression Profiles 1.0 1.16291 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null APP Pathway Commons Protein-Protein Interactions 1.0 null BRD-K96416345 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14194 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles 1.0 1.81135 NFATC1 ENCODE Transcription Factor Targets 1.0 null 9747_VPS28_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.799979 hsa-miR-4667-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 BRD-K78596805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31303 fertilizedegg BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.47319 FLI1 ChEA Transcription Factor Targets 1.0 null RERFLCAI CCLE Cell Line Gene CNV Profiles 1.0 2.35139 muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.868777 BRD-K59006776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14155 GSE68155_1_v_0_gpr3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney Chromophobe_KICH_TCGA-KO-8410-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-Q3-A5QY-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE228106_0_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null PPP4R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.65532 GTEX-XBED-0826-SM-47JYC GTEx Tissue Sample Gene Expression Profiles 1.0 0.888768 SNRNP40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59132 nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044612 RAD21 ENCODE Transcription Factor Targets 1.0 null BRD-K48389518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18956 GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12951 BRD-K77109731 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42131 GSE112860_0_v_4_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null phosphatidylinositol metabolic process GO Biological Process Annotations 2015 1.0 null MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.96504 BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.835758 internal male genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GSE149903_4_v_2_myd88_mouse RummaGEO Gene Perturbation Signatures 1.0 null Whole Blood GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.24689 posterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.868534 layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.01459 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6UY-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F4 ENCODE Transcription Factor Targets 1.0 null FE-56-PV35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.523113 GSE102486,GSE102490_1_v_5_setdb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Asphyxia DisGeNET Gene-Disease Associations 1.0 null rhabdomyolysis-myalgia syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.779 skeletal muscle HPA Tissue Protein Expression Profiles 1.0 0.910487 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.879913 GSE192663_1_v_5_acly_mouse RummaGEO Gene Perturbation Signatures -1.0 null PDCL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27392 H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles 1.0 3.05036 bj HPA Cell Line Gene Expression Profiles -1.0 -0.930183 congenital heart disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.416147 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-125a-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.348832 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null BRD-K59571728 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77511 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null imatinib_homo sapiens_gpl96_gds3045 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.40787 GSE57871_11_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TD-48-XJ84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.262036 GTEX-T2IS-0011-R6A-SM-32QP2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44393 hippocampus (hippocampal formation)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1288 H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXM1 ChEA Transcription Factor Targets 1.0 null KDM1A ENCODE Transcription Factor Targets 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE213588_10_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SF295 DepMap CRISPR Gene Dependency 1.0 2.66073 posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.841797 impaired smooth muscle contractility MGI Mouse Phenotype Associations 2023 1.0 null GSE95077_5_v_2_amiloride_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FOXM1-23109430-U2OS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.554059 5729_NOC2L_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.554498 496100596_FWM_dementia_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.75649 hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.67798 GABPA_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF4_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-PBX3-Unnamed_3_PBX3 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K62536891 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.97413 GSE116810_5_v_1_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_7_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_4_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null impaired coordination MPO Gene-Phenotype Associations 1.0 null LF-94-HB11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.667221 NB10 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.24509 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.204 GTEX-QXCU-0006-SM-2TC5K GTEx Tissue Sample Gene Expression Profiles 1.0 1.60011 BRD-K55869732 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08697 RFX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K60781525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14634 amygdaloid complex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16756 GSE179880_2_v_5_e2f4_mouse RummaGEO Gene Perturbation Signatures -1.0 null 9481_UBA52_P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.502217 H3K9ac_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCLC-21H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.41685 GSE212486,GSE212488_2_v_3_gata4_mouse RummaGEO Gene Perturbation Signatures -1.0 null A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.42932 H3K79me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 10123_ZIC5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.550054 abnormal muscle morphology MPO Gene-Phenotype Associations 1.0 null BRD-K14795621 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70975 female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null hsa-miR-4277 TargetScan Predicted Conserved microRNA Targets 1.0 0.175726 A549_CEP-33779_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0131193 Acute Myeloid Leukemia_LAML_TCGA-AB-2948-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LMO2 ChEA Transcription Factor Targets 1.0 null MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null thp1 HPA Cell Line Gene Expression Profiles 1.0 0.863317 3p deletion syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.935 Phagophore assembly site membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.45 BRD-K76609014 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.2705 BRD-K42828928 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38208 GSE99875_2_v_0_everolimus_human RummaGEO Drug Perturbation Signatures 1.0 null JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DC-23-UM36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.419854 NCI-H1975 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.0154 5637 COSMIC Cell Line Gene CNV Profiles 1.0 2.76305 GSE196505,GSE196507_3_v_2_kdm2b_human RummaGEO Gene Perturbation Signatures 1.0 null pre-autophagosomal structure COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.716791 A549_NVP-BSK805 2HCl_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0116836 cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.851634 FADU COSMIC Cell Line Gene Mutation Profiles 1.0 null BC-54-ON71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.528973 BC-15-EL49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.385775 Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE100316_5_v_2_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.87197 abnormal motor capabilities/coordination/movement MPO Gene-Phenotype Associations 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE254517_2_v_0_irf7_mouse RummaGEO Gene Perturbation Signatures 1.0 null Tibialis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.184 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-R55G-0326-SM-48FDM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.944859 EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.690024 DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.91531 18535662-TableS2b GeneSigDB Published Gene Signatures 1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null VI, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15704 molecular_function GO Molecular Function Annotations 2015 1.0 null MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null impaired coordination MGI Mouse Phenotype Associations 2023 1.0 null sporadic GeneRIF Biological Term Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null XB-53-OZ95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.761602 GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.10817 K562_Belinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0245385 lateral mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40587 stem TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.073786 hsa-miR-148b TargetScan Predicted Conserved microRNA Targets 1.0 0.766596 CB-16-SY72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.0344 SUIT2 CCLE Cell Line Gene Expression Profiles -1.0 -2.13374 noscapine-5851 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC7614775-EMS178742-supplement-Proteomics_Table_1.pdf-112-GMEB2_GMEB2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K38248167 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.85228 TAF7 ENCODE Transcription Factor Targets 1.0 null PMC8410083-elife-65574-fig7-data1.xlsx-KLF10_network-Genes_bound_by_KLF10_in_their_-10_1kb_region_or_differentially_expressed_in_WT_vs_HepKO_hepatocytes_challenged_with_high_sugar_KLF10 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-631 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 NCIH2347 CCLE Cell Line Gene Expression Profiles 1.0 1.44453 BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Macrocephaly DisGeNET Gene-Phenotype Associations 1.0 null lateral hypothalamic area, mammillary region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -3.02991 GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Asthma, allergic_Lung Tissue_GSE3184 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.64284 MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.12116 BRD-K70116387 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.0526 GSE195559_3_v_4_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null RXRA ENCODE Transcription Factor Targets 1.0 null hsa-miR-3665 TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23K-01A-11R-A16R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-LI-A9QH-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectus femoris TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.271 decreased male germ cell number MGI Mouse Phenotype Associations 2023 1.0 null PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Macaque_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autosomal Recessive Centronuclear Myopathy DisGeNET Gene-Disease Associations 1.0 null CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE127790_4_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7539-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100372_HIP_dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.29373 H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.918788 HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06443 BRD-K88542817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.80472 GSE241036_0_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Fluorouracil_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0187169 AB-21-VE32_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.205886 BRD-K88527653 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16098 CRCGN015_MCF10A.TP53.M_24H:P13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.02485 GSE172458_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null BRD-K31672963 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56831 GTEX-R55D-0626-SM-3GAD5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0127 Biceps brachii TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.986 GTEX-X5EB-0626-SM-46MVQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.328 Cell surface furrow COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.934 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01155 hematopoietic cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null ACTL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51875 uterine disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.443923 GTEX-R55D-0006-SM-3GIJS GTEx Tissue Sample Gene Expression Profiles 1.0 1.32401 BRD-K07836769 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26533 HCFC1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.1331 BL2365 (KIAA0528) NURSA Protein Complexes 1.0 null reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.066334 GM1600 BioGPS Cell Line Gene Expression Profiles -1.0 -1.48965 CD-16-KY17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.326425 Psoas_Muscle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.938354 LU-65 COSMIC Cell Line Gene Mutation Profiles 1.0 null STAT1::STAT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.6484 Perturb_15365_KO_Klf2_SRP064312 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.73334 GTEX-U8XE-0626-SM-3DB8U GTEx Tissue Sample Gene Expression Profiles -1.0 -2.04216 BRD-K41241300 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18565 BRD-K03654379 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62083 Prostate adenocarcinoma_PRAD_TCGA-VP-A872-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.26578 Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.278 SIX5_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMRT-22465074-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16917 dactinomycin_mus musculus_gpl6246_gse21233 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.990788 IRF4 ENCODE Transcription Factor Targets 1.0 null DB-21-FY75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.78608 BRD-K14246348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91356 GSE173262_6_v_0_ash1l_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T5JC-0011-R2A-SM-32PLZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13639 H4K5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 3537_GRINA_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.530176 BRCA1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148510_3_v_2_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null USF1 ENCODE Transcription Factor Targets 1.0 null inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.51267 NR2C2 ENCODE Transcription Factor Targets 1.0 null INSM1_Deficiency_GDS5066_272_mouse_Fetal pituitary glands from embryonic day 17.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null macromolecule modification GO Biological Process Annotations 2015 1.0 null Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.1 l45 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.601 BRD-K45508763 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40035 9909_XRCC6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.529862 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09572 H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null female reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Macaque_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null MCF7_Aminoglutethimide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0175476 IKZF1 ENCODE Transcription Factor Targets 1.0 null Huntington's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.314 GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.0952 BRD-K69396470 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.91828 GTEX-Q2AG-0011-R5A-SM-2HMJH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845005 Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5580-11A-02R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K10987837 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23065 GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles 1.0 1.1447 Lung squamous cell carcinoma_LUSC_TCGA-51-4080-11A-01R-1758-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Motor neuron disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.078 SYK_KD_GDS3609_440_human_MCF10A GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-U3ZH-0626-SM-4DXT3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.86826 H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-62-A46U-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158834_11_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null SNU-175 COSMIC Cell Line Gene Mutation Profiles 1.0 null cellular process GO Biological Process Annotations 2015 1.0 null BRD-K05335635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60353 GSE174418,GSE174421_2_v_3_mettl5_mouse RummaGEO Gene Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JH-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETS1_ETS1 Rummagene Transcription Factor Associations 2026 1.0 null inner SZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.899793 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17504 BRD-K45665532 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43981 caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.49605 GTEX-X261-0011-R5A-SM-3NMB4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.843154 Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE198165,GSE198166_8_v_4_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null Extensor digitorum longus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.201 BRD-K62351887 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30265 SYK_knockdown_191_GSE54065 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.66765 BRD-K21897482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16566 AC-47-YZ27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.478472 GTEX-QCQG-0226-SM-48U28 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00482 Z disc COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.329 BRD-K75672292 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02696 GSE195559_0_v_9_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null FEV JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.7788 RCM1 DepMap CRISPR Gene Dependency 1.0 4.82675 BRD-K27398402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64746 GSE122101,GSE122103_0_v_1_ssu72_mouse RummaGEO Gene Perturbation Signatures 1.0 null King Denborough syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.277 Prostate adenocarcinoma_PRAD_TCGA-M7-A71Y-01A-22R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7430-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.TP53.M_24H:E17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.29753 RCCFG2 DepMap CRISPR Gene Dependency 1.0 4.82314 Abscission zone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.74 RERFLCAI CCLE Cell Line Gene Expression Profiles 1.0 1.87171 7608_RUVBL2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.579526 GTEX-TSE9-0011-R6A-SM-3DB7L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13634 RELA_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null vacuole LOCATE Predicted Protein Localization Annotations 1.0 null SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE175787_4_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A.TP53.M_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.75255 BRD-K31806725 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10447 HES6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4649 PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3 Rummagene Transcription Factor Associations 2026 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A685-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BD-61-OO16_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.289307 GTEX-QDT8-0006-SM-32PL3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25127 GSE175787_13_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null Pax7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.0166 DND-41 COSMIC Cell Line Gene Mutation Profiles 1.0 null CD4_Memory_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.05727 SG in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14214 ZMIZ1 ENCODE Transcription Factor Targets 1.0 null provides GeneRIF Biological Term Annotations 1.0 null Sarcoma_SARC_TCGA-3B-A9HJ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K88323568 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35237 MAX ENCODE Transcription Factor Targets 1.0 null COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.839889 UM-UC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50467 ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null XA-12-UL84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.280139 CRCGN015_MCF10A.WT.HP_24H:N11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.05709 A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_18Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.15444 Charcot-Marie-Tooth disease intermediate type DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.306 peroxisome LOCATE Predicted Protein Localization Annotations 1.0 null POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MHHCALL4 CCLE Cell Line Gene Expression Profiles 1.0 1.39198 GSE110178_4_v_7_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04689 abnormal cardiovascular system morphology MPO Gene-Phenotype Associations 1.0 null GSE48812_2_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FB-49-NW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.792676 CIBAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29253 CRCGN017_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.94991 Perturb_1211_KO_Zfp580_SRP302435 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.6742 NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HIGD1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48332 SMAD1-26771354-MESC-MOUSE-STEM ChEA Transcription Factor Targets 2022 1.0 null POU2F2 ENCODE Transcription Factor Targets 1.0 null GSE236262_0_v_3_trim28_mouse RummaGEO Gene Perturbation Signatures -1.0 null LA-42-ER00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.734043 GSE109530,GSE109531_1_v_3_hdac3_mouse RummaGEO Gene Perturbation Signatures 1.0 null SPI1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null KASUMI1 DepMap CRISPR Gene Dependency 1.0 2.48365 prdm1_00000000_e9dot5_placenta_lof_mouse_gpl6887_gse39584 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.573777 BRD-K60389305 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93007 BRD-K26709432 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48986 GSE180800,GSE180801_0_v_5_tex10_mouse RummaGEO Gene Perturbation Signatures -1.0 null XPNPEP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12709 DorsalRootGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.7457 PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null PMPCB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.7871 DF-75-OU25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.355105 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YU-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6481-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.989923 CBX3_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tcf21 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.5757 female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF7L2 ENCODE Transcription Factor Targets 1.0 null GABP-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles 1.0 0.856774 parathyroid gland HPA Tissue Protein Expression Profiles 1.0 0.910487 MDAMB436 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.960721 pancreas_6b HPA Tissue Sample Gene Expression Profiles -1.0 -2.46968 YD38 CCLE Cell Line Gene CNV Profiles -1.0 -2.23856 FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MFE-296 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.64301 BT549 CCLE Cell Line Gene CNV Profiles 1.0 1.42559 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null oocyte BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.02814 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PIPOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14009 NOP14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72326 VMRCLCD CCLE Cell Line Gene CNV Profiles -1.0 -1.67911 MCF7_EED226_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.017033 GSE213588_8_v_12_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-S7PM-0011-R6A-SM-3NM8F GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14722 dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04807 HCC2935 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.17194 H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K65506286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04347 HC-01-FD24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.670635 emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19859 GSE196259_2_v_3_gcm1_human RummaGEO Gene Perturbation Signatures 1.0 null LA-42-ER00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.15962 GTEX-OHPN-0011-R1A-SM-2I5GB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16345 GTEX-UTHO-0011-R3A-SM-3GIK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18957 abnormal metabolism MPO Gene-Phenotype Associations 1.0 null BRD-K44483161 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2565 muscular atrophy MPO Gene-Phenotype Associations 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_10_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null protein dephosphorylation GO Biological Process Annotations 2015 1.0 null CRCGN016_MCF10A.WT.HP_24H:G02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.32768 GSE146612_2_v_0_amiodarone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE231891_1_v_4_cdk8_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K67632894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5775 SNRPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03683 cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.045936 H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 GSE235390_4_v_0_lurbinectedin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-U3ZH-0002-SM-3NMDD GTEx Tissue Sample Gene Expression Profiles 1.0 0.903493 LY2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 2.03713 amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.67801 GSE171175,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-135a TargetScan Predicted Conserved microRNA Targets 1.0 0.274552 GSE242290_3_v_11_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3426-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PW2O-0826-SM-48TC5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03087 posteroventral (inferior) parietal cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.941739 A-Vietnam-1203-2004(H5N1)_12Hour_21865398_GSE28166 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.26914 GSE157296,GSE157298_4_v_3_kbtbd4_human RummaGEO Gene Perturbation Signatures -1.0 null GM2313 BioGPS Cell Line Gene Expression Profiles -1.0 -1.12428 POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE223008_11_v_12_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-P4QR-0726-SM-2I5GO GTEx Tissue Sample Gene Expression Profiles 1.0 1.05896 GSE84922,GSE84924_0_v_3_sall4_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null FD-91-OK66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.907605 GTEX-P4PQ-1026-SM-3NMCN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968531 GSE149903_0_v_7_myd88_mouse RummaGEO Gene Perturbation Signatures -1.0 null YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148066,GSE157787_0_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hamstring muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.209 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE172295_0_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K42496940 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71233 layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.38075 SPI1-22790984-ERYTHROLEUKEMIA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K37219127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83335 USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PSDG-0926-SM-2I5FP GTEx Tissue Sample Gene Expression Profiles 1.0 1.28112 GSE240439_1_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null FOXP1-21924763-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN015_MCF10A.TP53.M_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0235 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE160246_9_v_1_cpeb4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE130690,GSE130692_2_v_0_sirt6_mouse RummaGEO Gene Perturbation Signatures 1.0 null glycerophospholipid biosynthetic process GO Biological Process Annotations 2025 1.0 null GTEX-OIZG-0005-SM-2HMJC GTEx Tissue Sample Gene Expression Profiles 1.0 1.00844 BRD-K71574401 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44649 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08142 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.20878 GSE137144_5_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures 1.0 null TBX2-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null mania GWASdb SNP-Phenotype Associations 1.0 0.465095 H3K27ac_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null fastigial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.985201 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043134 behavior/neurological phenotype MPO Gene-Phenotype Associations 1.0 null SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null small molecule metabolic process GO Biological Process Annotations 2015 1.0 null orbital frontal cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.931051 CRCGN011_HEPG2_24H:I10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0016 BRD-K10269761 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04389 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.962372 Danon disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.452 disrupts GeneRIF Biological Term Annotations 1.0 null primary motor cortex (area M1, area 4)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.956279 pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.152521 7454_RPL27A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.647088 CD14+_Monocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.09139 BRD-K74015591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39693 GSE158969_1_v_0_trastuzumab_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null Reduced Fetal Movement DisGeNET Gene-Phenotype Associations 1.0 null NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0449 NFIC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49623 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles 1.0 1.95594 GSE149359_2_v_1_asap2_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null RELA_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K98451611 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01298 FOXA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K35726223 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28782 affect GeneRIF Biological Term Annotations 1.0 null SRF ENCODE Transcription Factor Targets 1.0 null DMS153 CCLE Cell Line Gene Expression Profiles -1.0 -1.51884 SKMM2 Achilles Cell Line Gene Essentiality Profiles -1.0 -2.13693 BRD-K52592505 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58671 dioxybenzone-5699 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DHPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05648 vitamin c_homo sapiens_gpl570_gds3635 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null phosphatidylinositol biosynthetic process GO Biological Process Annotations 2023 1.0 null NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.962372 V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.908646 Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COPS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60049 STAT1 ENCODE Transcription Factor Targets 1.0 null CRCGN012_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15334 GTF3C2-35216376-H9-HUMAN-BONEMARROW-LYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null K562_Avagacestat_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0165029 CMK COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XGQ4-0226-SM-4GIDS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28522 BRD-K15350548 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.95297 GTEX-XOTO-0011-R9A-SM-4GICI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54211 Long QT syndrome 9 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.372 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7SF-0006-SM-3K2B6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.5535 KAT2A ENCODE Transcription Factor Targets 1.0 null GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.897941 BRD-K64742599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14493 Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE125011_0_v_2_cd83_human RummaGEO Gene Perturbation Signatures -1.0 null occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.86536 hsa-miR-148a TargetScan Predicted Conserved microRNA Targets 1.0 0.766596 H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN008_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6361 VI, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.40706 DLD1 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.5698 FOXP2-23625967-PFSK-1-AND-SK-N-MC-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K77101974 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30347 USF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5886-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null estradiol_homo sapiens_gpl570_gse16683 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K93260425 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05254 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal behavior MPO Gene-Phenotype Associations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-5481-11A-01R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4863-11A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HTC-C3 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.15237 HCC70_BREAST CCLE Cell Line Proteomics 1.0 3.7662 K562_Tazemetostat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0174063 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 3054_FECH_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.577135 HUPT4 CCLE Cell Line Gene CNV Profiles 1.0 1.61589 Urinary tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SARS-BatSRBD_0Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.66821 PMC3290552-pone.0032232.s006.xls-MUC4-KD_vs_Mock-Unnamed_3_AR Rummagene Transcription Factor Associations 2026 1.0 null SC-242 (ATF2) NURSA Protein Complexes 1.0 null GTEX-WOFM-1326-SM-3MJFR GTEx Tissue Sample Gene Expression Profiles 1.0 1.71999 GTEX-NL3H-0011-R4a-SM-2I3GK GTEx Tissue Sample Gene Expression Profiles -1.0 -2.52393 RERFGC1B CCLE Cell Line Gene Expression Profiles 1.0 1.89838 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE152432_1_v_2_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SARS-CoV MA15_Day4-PFU-10^5_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.86646 GTEX-XXEK-1826-SM-4BRVC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00058 mediodorsal nucleus of thalamus_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.491 GSE190186,GSE190188_8_v_5_apoe_mouse RummaGEO Gene Perturbation Signatures 1.0 null T3M4 BioGPS Cell Line Gene Expression Profiles -1.0 -1.01569 hESC Derived CD184+ Endoderm Cultured Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.06582 H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.236 FOSL2 ENCODE Transcription Factor Targets 1.0 null GSE110248_1_v_6_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Tozasertib_10然_72h Sci-Plex Drug Perturbation Signatures 1.0 0.012483 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F2-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 CRCGN009_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.54067 Chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0