association	dataset	threshold value	standardized value
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
layer 6a of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14757
Brain Lower Grade Glioma_LGG_TCGA-HW-7491-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.888284
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.99058
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.13426
Perturb_8215_KD_SUB1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.47393
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89348
Perturb_7031_KD_Casz1_SRP038989	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.37654
BRD-K97339945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11294
GTEX-XQ3S-1126-SM-4BOPK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883851
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44388
GSE167324_2_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100396_HIP_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04313
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836746
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26585
LOUNH91	DepMap CRISPR Gene Dependency	1.0	2.07491
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21255
HELZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34404
GTEX-R55E-2726-SM-48FCX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02274
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02188
GTEX-X88G-0426-SM-47JZ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874704
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SET2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67824
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.11961
tyloxapol-5672	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cellular carbohydrate metabolic process	GO Biological Process Annotations 2015	1.0	null
intermediate part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25452
TEAD4	ENCODE Transcription Factor Targets	1.0	null
Perturb_2322_KD_RBMX_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.47491
BRD-K89216747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02074
lateral subdivision of BNST	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06376
BRD-K80877725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14191
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051487
EGR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-QV31-1626-SM-2S1QC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K64132098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73125
BRD-K61486072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46002
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864237
Precatalytic spliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.623
CDC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57379
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_9120_KD_RNF213_SRP346985	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.3474
Water	HMDB Metabolites of Enzymes	1.0	null
Perturb_14093_KD_HDAC1_SRP199194	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.90628
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03918
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17392
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LS-01A-22R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KARPAS1718	DepMap CRISPR Gene Dependency	1.0	2.62133
FOXA2	ChEA Transcription Factor Targets	1.0	null
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DPYSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13289
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.964137
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73098
Perturb_14572_KO_EP300_SRP336466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.15257
Liver Diseases	CTD Gene-Disease Associations	1.0	1.52987
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07829
16166618-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE200673,GSE200691_2_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.14823
VDR-21846776-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_15098_KD_PDHA1_SRP385600	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.93117
mantle zone of m2AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54203
GTEX-RU72-0008-SM-46MV8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943222
Perturb_8190_KD_HNRNPU_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.27577
Methotrexate_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0271183
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.41898
GSE130383_1_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09676
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.49078
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931498
GTEX-QLQW-0726-SM-447AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0281
clomifene-6648	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cochlear nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.865834
ABL1_knockdown_144_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.25915
hsa-miR-129-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.9383
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
GTEX-XYKS-2226-SM-4E3IU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873186
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885567
Perturb_4758_KO_DLG2_SRP315088	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.56176
A3-KAW	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K27me3_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEL4-1426-SM-447AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.96483
CRCGN015_MCF10A_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03853
mantle zone of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45484
GSE127790_6_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QCQG-0126-SM-48U27	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XMD1-0011-R10A-SM-4AT4A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961639
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.863849
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10528072-NIHMS1928302-supplement-5.xlsx-ASCL1-target_genes-ABAT_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47618355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1357
PMC3573729-nl3042917_si_005.xlsx-OWY_Overlap_with_ANOVA-ORKIN_NMYC_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
PAX3-FKHR-20663909-RHABDOMYOSARCOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
promethazine-6477	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K62795540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28596
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0281
Perturb_8184_KD_DHX30_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.53703
GLI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14281
hsa-miR-4756-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Perturb_15391_KD_CHD6_SRP399677	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.50101
Coelomocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
omeprazole-4951	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
superficial stratum of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84883
Perturb_8403_KD_Safb_SRP234723	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.67742
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.78845
RH41	CCLE Cell Line Gene Expression Profiles	1.0	1.39337
abamectin-2519	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09313
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.889835
ETC-206_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.027755
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2958
A-Vietnam-1203-2004(H5N1)_24Hour_None_GSE43204	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.23686
SU-DHL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39262
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.098343
RBBP5	ENCODE Transcription Factor Targets	1.0	null
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8177
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.898134
GSE171837_0_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K00363054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69995
MKN7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86869
A427	GDSC Cell Line Gene Expression Profiles	1.0	1.54966
BRD-K53953065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16385
TET2_KO_GDS4287_430_mouse_CMP - bone marrow progenitor population	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
RXF393	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16506
PMC9170821-JCMM-26-3183-s001.xlsx-Oligo_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78104
neomycin-7221	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RU72-3126-SM-46MUB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17536
BRD-K52379384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43922
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K62182950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72624
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
subcallosal cingulate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.83494
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K13301506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00564
BRD-K01978082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66626
OSC20	DepMap CRISPR Gene Dependency	1.0	2.91383
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HOP-62	GDSC Cell Line Gene Expression Profiles	-1.0	-1.67157
BRD-K77591784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90007
GSE133087_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857369
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.35721
levallorphan-tartrate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00011
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K71538933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87648
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A510-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02565
GSE142684_0_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941125
LN-18 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.343
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869135
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K44713204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32786
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941921
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A7IP-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
subethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03608
LAMA-84	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_6504_KD_PIEZO1_SRP140640	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.0037
Perturb_7508_OE_ILF2_SRP195616	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.86588
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05952
HCC38	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47052
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3014
KDM5B	ENCODE Transcription Factor Targets	1.0	null
Perturb_15521_OE_proL1_SRP277452	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.55977
PMC3573729-nl3042917_si_005.xlsx-OWY_Overlap_with_ANOVA-ORKIN_ESRRB_ESRRB	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.86969
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.40879
GSE93674_2_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_7233_KO_ADIPOR2_SRP285935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.80016
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
MZ in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.890773
GSE65617_2_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06844
BRD-K76922696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56316
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COR-L88	GDSC Cell Line Gene Expression Profiles	1.0	2.36137
GSE114284_4_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.45512
Pancreas-pancreatic beta cell	Tabula Sapiens Gene-Cell Associations	1.0	0.698609
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Basal ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JN-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
trigeminal	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.21445
GSE148066,GSE157787_2_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K96663576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08141
Perturb_8162_KD_SNRNP70_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.40359
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.72277
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	1.0	3.46758
GTEX-S4UY-0006-SM-3K2A7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
SARM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74569
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Charcot-Marie-Tooth disease type 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.618
CRCGN012_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40105
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_4258_KD_HOXB13_SRP201342	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.33029
nutrition disease	GWASdb SNP-Disease Associations	1.0	0.391259
avian pallium	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-XPT6-0126-SM-4B65S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838388
telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14613
GSE174383_6_v_0_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JC-1726-SM-4DM6U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04877446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09068
pheniramine-4012	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_17210_KD_JUN_SRP188712	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	19.699
OV-90	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H2BK120ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.57251
ZNF263	ENCODE Transcription Factor Targets	1.0	null
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.31985
PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S9-ZNF384_SpecDMCs-Unnamed_3_ZNF384	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
r10 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06778
phosphatidylinositol-3,5-bisphosphate phosphatase activity	GO Molecular Function Annotations 2025	1.0	null
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31649
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.849118
BRD-K48899005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03846
BRD-K92767663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2045
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
plagl2_17983586_small_intestine_lof_mouse_gpl1261_gds3010	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.231385
Perturb_14161_KD_BZW1/BZW2_SRP316321	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.85712
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41867
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6796-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K27me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A2J0-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rovs	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.911
Simotinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0368816
NCI-H820	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.67322
Capmatinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.025884
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03311
PMC12729234-10194_2025_2222_MOESM1_ESM.xlsx-Table_S6-Table_S6_MR_results_of_the_significant_genes_from_human_brain_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.25778
MEG01	CCLE Cell Line Gene CNV Profiles	1.0	1.47757
H3K27me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K85917058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51617
PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6826
superficial stratum of r7Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19578
Posterolateral visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.93607
GTEX-WL46-0011-R9A-SM-3MJFP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36562
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.08206
posteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02268
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.88872
SW1116	GDSC Cell Line Gene Expression Profiles	-1.0	-1.83219
BRD-K14255526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83174
GSE65617_2_v_3_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MEL270	DepMap CRISPR Gene Dependency	1.0	4.65146
single-organism process	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Rectum adenocarcinoma_READ_TCGA-AG-3732-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951557
BRD-K95927760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33469
layer 1 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.02586
Body Mass Index	dbGAP Gene-Trait Associations	1.0	0.362285
Belzutifan_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0235736
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Oculocerebrorenal syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.34
PMC3573729-nl3042917_si_005.xlsx-OWY_Overlap_with_ANOVA-ORKIN_E2F1_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
multiform (lateral) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44084
Sox3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.9439
HS 940.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13143
mantle zone of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29239
novobiocin-na	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85787
chemdependency	GAD High Level Gene-Disease Associations	1.0	0.293278
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4735-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15901_KD_Jun_SRP361315	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.1156
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-WVLH-3126-SM-3MJGA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899559
HCC4006	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.861067
Perturb_4311_KD_SMRT_ERP126775	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.68106
Perturb_14803_KD_Gm26917_SRP340980	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K37454185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10281
PRMT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02314
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_DN3_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
EIF2B5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27937
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6114
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02576
BRD-K26074237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41611
variant creutzfeldt-jakob disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.958705
CRCGN010_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17105
clidinium bromide-2734	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE223008_5_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145639_7_v_4_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
smooth muscle	HPA Tissue Protein Expression Profiles	1.0	1.8551
GSE214382,GSE214383_1_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
noscapine-5851	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.01073
NCIH2196	CCLE Cell Line Gene Expression Profiles	1.0	1.56041
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TWF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25001
Protein-tyrosine/Dual specificity phosphatase	InterPro Predicted Protein Domain Annotations	1.0	null
Perturb_11829_KO_Pxdc1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.53083
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Docetaxel_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.013963
MZ in posterodorsal (superior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01077
GSE234647_1_v_3_regorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41915
anterior digastric muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40058
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.954818
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Charcot-Marie-Tooth disease type 4B2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.794
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900869
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.982885
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69863
Charcot-Marie-Tooth disease dominant intermediate B	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.009
BRD-K38111331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40303
BRD-K97962579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01689
dorsal preisthmic part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54203
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857538
hsa-miR-186	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE180185_4_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53548223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15291
BT549	CCLE Cell Line Gene CNV Profiles	1.0	1.50842
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44177
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4P0-01A-41R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K39211770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19238
RS11846	BioGPS Cell Line Gene Expression Profiles	1.0	0.871692
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.97784
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.44949
lateral tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37031
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.30341
BRD-K90821428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1299
Perturb_17209_KO_miR92a1_SRP050491	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.86602
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.978314
abnormality of refraction	GWASdb SNP-Phenotype Associations	1.0	0.3612
PAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12357
sensory system disease	GWASdb SNP-Disease Associations	1.0	0.08469
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
GSE100316_3_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14654
Perturb_6871_KD_HHEX_SRP323378	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.45974
LU99	CCLE Cell Line Gene CNV Profiles	-1.0	-2.02126
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-3126-SM-4AT6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00184
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.78492
lateral hypothalamic area, anterior part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.886805
BRD-K39411863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24064
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998954
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93498
single-organism carbohydrate metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889677
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K15202679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18773
Perturb_10323_KO_MYC/Setd2_SRP310502	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.92573
PIK3CA_mutant_27_GDS4053	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.91281
GTEX-RVPV-0526-SM-47JYL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10330983-ab-22-0432-Supplementary-Table-10.pdf-73-MTERF1_MTERF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912685
Uterine Carcinosarcoma_UCS_TCGA-NA-A4R1-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-623	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
ESRRB-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-W3-A825-06A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26709432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66966
Sarcoma_SARC_TCGA-IE-A3OV-01A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Omeprazole_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0277772
Chlorhexidine (diacetate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0218657
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HV-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TGBC24TKB	GDSC Cell Line Gene Expression Profiles	1.0	2.21135
BRD-K81322049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32271
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AOB, internal plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31113
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54276
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4225-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fc-gamma receptor I complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.091
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_11910_KD_Hmga2_SRP029975	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.56211
Anterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.90857
m1AD (DM) part of periaqueductal gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04444
eye and adnexa disease	GWASdb SNP-Disease Associations	1.0	0.102948
H3K9me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78702
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16774
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02508
Fetal Heart	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.894052
intermediate stratum of DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21593
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.5602
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.777095
CAL-12T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.848682
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ntera2	HPA Cell Line Gene Expression Profiles	1.0	1.12268
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6221-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.844143
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44R-06A-41R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Accessory olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02591
GSE88819_3_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Anterolateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45484
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	GO Molecular Function Annotations 2025	1.0	null
Fatty acid elongase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.049
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE133505_5_v_4_myf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SKN	DepMap CRISPR Gene Dependency	1.0	7.18695
GSE122215,GSE122217_5_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE113329,GSE113335_3_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ECC12	CCLE Cell Line Gene Expression Profiles	1.0	1.41313
BRD-K47558670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05829
GTEX-NPJ8-2626-SM-2D7W2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906787
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89326
18535662-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
GSE182680,GSE182683_10_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-501-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
layer 6 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14757
superficial stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13191
protein binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dentate gyrus, polymorph layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38557
GSE232631_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventral posterior inferior nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.951596
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924163
Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cerebellum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.14
Perturb_5725_KO_Mertk_SRP279562	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.91026
RPS18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01536
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4735-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.7524
TTC549	DepMap CRISPR Gene Dependency	1.0	4.50131
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19715
CRCGN016_MCF10A.TP53.M_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34573
Parkinson's disease 20	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.434
GTEX-OHPK-1826-SM-2YUMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966164
Acute Myeloid Leukemia_LAML_TCGA-AB-2863-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01416
GTEX-T2IS-0008-SM-4DM75	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21459
Perturb_8100_KD_ABCF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.55546
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31187110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25617
intermediate stratum of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20091
orbital frontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.42142
methotrexate-6654	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8294
medial parabrachial nucleus,right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.983096
Supplemental somatosensory area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22004
Perturb_14903_KO_PRMT6_SRP125977	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.72709
hsa-miR-4669	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
H3K9me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A48J-01A-21R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.53915
Perturb_440_KD_PRMT5_SRP073189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.0147
CRCGN014_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02916
MDAMB361	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32712
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19677
PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_3_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8494348-pone.0257161.s002.xlsx-D20-NOT_ext_ext-NOT_ext-Gene_Name_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TX-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75220555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08774
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3921
posterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.854642
GTEX-WZTO-0011-R7B-SM-4E3IS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868622
GTEX-N7MS-0826-SM-2HML4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
KARPAS-299 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.006
Perturb_11378_KD_OGT1_SRP311080	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.74169
hsa-miR-4762-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Synthesis of IP2, IP, and Ins in the cytosol	Reactome Pathways 2024	1.0	null
GSE199255,GSE199356_4_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138019_4_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4975
Belinostat_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0201493
BRD-K15201964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00089
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19097
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN009_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06782
GTEX-U412-0826-SM-3DB9K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849464
Perturb_14110_OE_C11orf53/Pou2f3_SRP343255	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.96964
internal cortical nucleus of inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0178
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OIZH-1326-SM-3NB1H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.105238
medial tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6937
GTEX-UTHO-2926-SM-3P5Z9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2517
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.24655
Inferior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.23754
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01046
BRD-K36368568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18264
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49591
rt4	HPA Cell Line Gene Expression Profiles	1.0	0.935361
globose nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3138
SOX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.25
GSE94849_3_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IRS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32378
CRCGN012_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00284
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08762
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39419290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31221
disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
KDM5B-21448134-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-0126-SM-48FDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
SNU668	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5871
BRD-K13257316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28321
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WS-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2249
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065394
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.317
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898607
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.6448
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911352
saquinavir-3549	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
(S)-Crizotinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0242178
DENR	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K47694606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08495
Perturb_7567_KD_CPSF6_SRP327319	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE214823,GSE214824_0_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91021
Perturb_7632_KD_AF9_SRP078067	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.02792
PI Metabolism	Reactome Pathways 2024	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87457
BRD-K91490997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23294
Perturb_17551_KD_PHF14_SRP354496	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.33168
BRD-K72050226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8735
GSE246053_1_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841612
PMC11732233-mmc1.pdf-24-PRDM2_PRDM2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4QT-0126-SM-2I3FL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.823954
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969941
intermediate stratum of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30711
subgenual (subcallosal) division of MFC (area 25)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.59712
lung disease	GWASdb SNP-Disease Associations	1.0	0.641537
C14orf119	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44542
Metabolism of lipids	Reactome Pathways 2024	1.0	null
Phagophore assembly site	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.809
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82508
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	1.0	3.13001
GPHA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06824
superficial stratum of PCPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27678
phosphatidylinositol biosynthetic process	GO Biological Process Annotations 2015	1.0	null
adrenal_4d	HPA Tissue Sample Gene Expression Profiles	1.0	0.998754
GSE130383_2_v_3_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH810	CCLE Cell Line Gene Expression Profiles	1.0	1.9456
KDM2B-26808549-CHIP-SEQ-REH-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
COLO201	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.967851
Perturb_3126_KO_Stra6l_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.42126
respiratory system disease	GWASdb SNP-Disease Associations	1.0	0.192787
hsa-miR-4446-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21414
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8752
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.3104
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871582
Perturb_5395_KD_LIM1_SRP402415	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.72442
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66186
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.983924
CRCGN016_MCF10A.WT.HP_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2804
GTEX-RNOR-2426-SM-48FDY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98291
BRD-K00620786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15876
Perturb_242_KD_Blimp1_SRP094038	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
PMC12640707-NIHMS2124006-supplement-Supplemental_tables.xlsx-Supplemental_Table_S5-Supplemental_Table_S5_Genes_commonly_downregulated_in_both_clones_of_ZFX-depleted_HEK293T_cells_in_Ni_et_al_2020_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91810283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1091
RAB22A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27298
BRD-K26024910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18571
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876906
Perturb_11846_KO_Tmem106b_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.78043
body mass index	GAD Gene-Disease Associations	1.0	null
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53976
C99	DepMap CRISPR Gene Dependency	1.0	5.81944
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GSE149903_3_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.768635
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15442
Perturb_3573_KD_JAB1_SRP222371	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
r7 part of spinal trigeminal nucleus, interpolar part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2005
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PL-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebral lobe	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN011_HEPG2_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3387
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4609
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.92118
Perturb_8928_KD_CHD4_SRP350011	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.04449
Nuclear aryl hydrocarbon receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.591
BRD-K31081052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45697
DNMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16535
granule cell layer of the DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28198
hsa-miR-612	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149096_4_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
HT29	BioGPS Cell Line Gene Expression Profiles	1.0	0.95979
Uterine Carcinosarcoma_UCS_TCGA-N6-A4V9-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.454
bucladesine-2741	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	1.0	2.38818
dorsolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.914957
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
postcentral gyrus, right, bank of the posterior central sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.975462
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.19
Oligospermia	CTD Gene-Disease Associations	1.0	1.32251
Creutzfeldt-Jakob Syndrome	dbGAP Gene-Trait Associations	1.0	0.731179
BRD-K78222058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03944
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.27645
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14224
COLO668	CCLE Cell Line Gene Expression Profiles	1.0	1.47378
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30446
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.00248
GPATCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99091
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41481
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.909293
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03343
WSU-DLCL2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49074
GTEX-PLZ4-1626-SM-3P618	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970983
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.449
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3319-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67676
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z6-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.41928
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K40432489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49135
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
Anterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26326
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30544
GSE254848_4_v_13_ptges_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX3	ChEA Transcription Factor Targets	1.0	null
GTEX-XV7Q-2226-SM-4BRVY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887999
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PBX1	ChEA Transcription Factor Targets	1.0	null
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.713372
Phosphatidylinositol 3-kinase complex, class I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.805
SKNFI	CCLE Cell Line Gene Expression Profiles	1.0	1.38664
BRD-K85722065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11798
CAPAN1	CCLE Cell Line Gene Expression Profiles	-1.0	-3.58232
GSE175787_5_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.61605
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6463
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.78492
U-118MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.592
amygdaloid complex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.883114
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A24D-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer CP in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.881476
AOB, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05314
CRCGN015_MCF10A.WT.HP_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08822
Brain Lower Grade Glioma_LGG_TCGA-HT-7881-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04998
PEER cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.868
CRCGN013_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58686
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K19958830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06282
Perturb_7819_KD_DDX39B_SRP099127	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.37583
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42665
PMC9703992-peerj-10-14124-s005.xlsx-gene_sets_cub_to_canonical-TFAP2E_TFAP2E	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-1261	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.61641
RAB17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16074
periventricular stratum of m1AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04624
cycloserine-6782	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bolting stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.941
crizotinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.021789
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsal endopiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42505
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30307
BRD-K76713927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64338
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.751
epilepsy syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.632384
preweaning lethality, incomplete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
Synthesis of PIPs at the late endosome membrane	Reactome Pathways 2024	1.0	null
BRD-K34209560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24991
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
Protein-tyrosine phosphatase, active site	InterPro Predicted Protein Domain Annotations	1.0	null
CD63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08356
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47525
phosphatidylinositol dephosphorylation	GO Biological Process Annotations 2015	1.0	null
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07524
Perturb_10861_KO_Med23_SRP027536	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.51307
organophosphate catabolic process	GO Biological Process Annotations 2015	1.0	null
r7 part of paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.40546
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.05499
polyol catabolic process	GO Biological Process Annotations 2015	1.0	null
Perturb_7044_KO_miR17~92_SRP050491	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.34315
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
SOX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23942
CDK4_knockdown_143_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.37676
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877847
hsa-miR-576-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
hsa-miR-767-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
SNU182	CCLE Cell Line Gene CNV Profiles	-1.0	-2.07216
BRD-K08408085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13945
Tcf12	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3462
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907426
benzonatate-1843	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Phosphoric acid	HMDB Metabolites of Enzymes	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K96384208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22137
BRD-K36271521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0397
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15648
Creutzfeldt-Jakob Disease	DisGeNET Gene-Disease Associations	1.0	null
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10377
APTO-253_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00958527
nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049857
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
fenoprofen-4736	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.916959
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.950873
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979152
CAL-39	GDSC Cell Line Gene Expression Profiles	1.0	1.96279
Prostate-smooth muscle cell	Tabula Sapiens Gene-Cell Associations	1.0	0.494663
GTEX-X4XX-2926-SM-3NMB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21417
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905286
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27772
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.88864
BRD-K43029808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24513
PMC7523182-Table_2.XLSX-Lipid_metabolism_pathways-NFYA_NFYA	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-1626-SM-3K2AJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
rifamycin-sv	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10571
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00045
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-SIU7-1826-SM-2XCE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Perturb_11822_KO_Phtf1_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.94822
GSE114284_4_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12467
K562	CCLE Cell Line Gene Expression Profiles	-1.0	-1.8339
HCC-56	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K10540354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77863
SP1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
ZNF485	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09225
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5099-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JV-01A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K94196749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71265
Acute Myeloid Leukemia_LAML_TCGA-AB-2913-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nobox	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.3947
H3K36me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Flumatinib (mesylate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0244962
Piroxicam_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0123119
Demeclocycline_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0313524
PRDM1	JASPAR Predicted Transcription Factor Targets	1.0	null
CRCGN011_HEPG2_24H:A09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8476
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.70495
hsa-miR-302f	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Charcot-Marie-Tooth disease type 4J	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11983
Perturb_6468_OE_PROX1_ERP110083	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.40722
GTEX-X62O-2226-SM-46MW3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26722
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06602
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2749
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06907
Perturb_13370_KD_NR1D1_ERP118284	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.45064
BRD-K60828476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33481
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.38195
hsa-miR-3125	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
RPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77353
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-Q2AI-0626-SM-48TZU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857719
intermediate stratum of ITTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21028
Perturb_6891_KD_PIRIN_SRP375440	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_3409_KD_Zbtb10_ERP123680	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-REY6-1726-SM-48FDL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
anterior group of nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.51276
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39863565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.65376
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.932115
Ixazomib citrate_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.019429
GSE148692,GSE148695_2_v_4_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200673,GSE200691_1_v_4_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H660	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mantle zone of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14346
Parasubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48463
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19309
GSE210101,GSE210114_0_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49074
Perturb_1763_KD_Tcf1_SRP311399	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.18204
A253	COSMIC Cell Line Gene CNV Profiles	1.0	2.15402
PMC7335061-41467_2020_17150_MOESM4_ESM.xlsx-Table_S3-LIN28B_correlates_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-MB-A5Y8-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
thyroid gland	HPA Tissue Gene Expression Profiles	1.0	1.20529
hsa-miR-3938	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K99048639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54587
Perturb_2873_Mut_KRAS_SRP404927	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.45752
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
Charcot-Marie-Tooth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.341
BRD-K58743752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12302
BRD-K58324650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57278
CAOV4	DepMap CRISPR Gene Dependency	1.0	2.77277
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KURAMOCHI	GDSC Cell Line Gene Expression Profiles	-1.0	-1.73782
Lung adenocarcinoma_LUAD_TCGA-95-A4VP-01A-21R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OUMS-23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.39212
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940264
Perturb_8678_KD_AKAP8_SRP226172	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.61639
Perturb_2385_KO_ASXL2_SRP333775	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.47853
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53691
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
hsa-miR-583	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
protein dephosphorylation	GO Biological Process Annotations 2025	1.0	null
Perturb_2616_KD_TRIM28_SRP252344	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.87147
NIHOVCAR3	CCLE Cell Line Gene CNV Profiles	1.0	1.77955
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27901
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53976
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6945-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07524
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24741
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.89063
PMC11058205-42003_2024_6202_MOESM6_ESM.xlsx-Data3a_DirectGene_CEBPA-Data3a_Genes_directly_regulated_by_CEBPA_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
COLO684	CCLE Cell Line Gene CNV Profiles	1.0	1.46198
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Central nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
carbenoxolone-4093	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_8722_KD_HNRNPC_ERP012958	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.48315
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
phospholipid dephosphorylation	GO Biological Process Annotations 2015	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K57472585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27002
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Lung adenocarcinoma_LUAD_TCGA-86-A4D0-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.941917
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
NCI-H810	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Centronuclear myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.99
NCI-H2196	COSMIC Cell Line Gene Mutation Profiles	1.0	null
medial part of r10B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23139
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01761
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
SIN3A	ENCODE Transcription Factor Targets	1.0	null
protein dephosphorylation	GO Biological Process Annotations 2023	1.0	null
GSE175787_8_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78961368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45225
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cefsulodin-4148	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.09173
E2F6_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225901_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mediodorsal nucleus of thalamus_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.61521
CRCGN012_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05122
GTEX-QDT8-0011-R2A-SM-32PKQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55085
BRD-K75514760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05863
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.88859
BRD-K65932559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37382
PMC10641274-mmc2.xlsx-FOXK1_Insulin-SYMBOL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
posteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30711
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Lung adenocarcinoma_LUAD_TCGA-86-7701-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adrenal gland	HPA Tissue Gene Expression Profiles	1.0	0.975969
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_378_KO_HDLBP_SRP261899	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.31313
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EP300_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO-205	GDSC Cell Line Gene Expression Profiles	-1.0	-1.4413
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.5988
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HY-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06968
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U3-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterodorsal tegmental nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06715
H3K27me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
Perturb_2345_KO_CGAS_ERP131756	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.07002
BRD-K46620987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29793
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NADP	HMDB Metabolites of Enzymes	1.0	null
BRD-K11596967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32603
Pectoral muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.952
BRD-K43136464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03256
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.28294
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K83751422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06341
PMC12347849-mmc1.pdf-3-ENSG00000118526_TCF21	Rummagene Transcription Factor Associations 2026	1.0	null
valproic acid-4446	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-PWO3-1026-SM-2I5F2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84804
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10181932-41588_2023_1366_MOESM4_ESM.xlsx-Supplementary_Table_2-Supplementary_Table_2_Additional_information_for_all_SOX9-dependent_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_13683_KD_FTO_SRP116935	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.30968
Liver hepatocellular carcinoma_LIHC_TCGA-5R-AA1D-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
salivarygland_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.35338
Brain Lower Grade Glioma_LGG_TCGA-HT-7607-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50177531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63379
tail of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.41153
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.29386
SP in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.86576
AGTPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18721
periventricular stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.16075
Charcot-Marie-Tooth disease type 4B1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.939
CRCGN015_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22965
Perturb_2552_KD_TRIM28_SRP067706	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.15328
Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FGF22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3761
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47410882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07161
MV-4-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01732
tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.46132
Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.910568
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04155
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
RCM1	DepMap CRISPR Gene Dependency	1.0	2.28848
Perturb_10199_KD_RUNX1/RUNX1T1_SRP291095	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.87283
SKNMC	CCLE Cell Line Gene CNV Profiles	1.0	1.96553
17009876-tableS1a	GeneSigDB Published Gene Signatures	1.0	null
Sarcoma_SARC_TCGA-PC-A5DK-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43918582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16544
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99813
BRD-K79551673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41851
Brain Diseases	CTD Gene-Disease Associations	1.0	1.35906
posterior (ventral) nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.39234
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K25757224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04263
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04409515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66875
limbic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_8112_KD_SUPT6H_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.99618
Memory Disorders	CTD Gene-Disease Associations	1.0	1.64663
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6433-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Trimetrexate_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0255685
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.5055
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959622
PMC4123077-cddis2014283x10.xls-Sheet1-Table_S5_Genes_upregulated_by_HAND1_in_DLD1_cells_HAND1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6853299-pbio.3000476.s011.xlsx-Fig_4A-HVC_612_gene_expression_ratio_in_ZF_and_OF_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07471
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
prion disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.564889
Sarcoma_SARC_TCGA-DX-A23T-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
yohimbine-7130	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.76272
GSE88819_5_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.48495
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
Lung	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.568995
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K85044233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01443
Ventral posterolateral nucleus of the thalamus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04289
BRD-K33770771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62262
cerebellar cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21285
PBX1-22567123-OVCAR3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCIH524	CCLE Cell Line Gene Expression Profiles	1.0	1.50323
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14268
Perturb_6434_KD_HOXA10AS_ERP131886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.11408
GSE236228_0_v_1_penfluridol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09084
SBF transcription complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.593
GTEX-TSE9-0011-R6A-SM-3DB7L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.870559
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07829
H2BK12ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K13309514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48593
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.941606
HDDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0196
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12285
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A4-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K89089981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27351
BRD-K22071228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02922
BRD-K80880605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02146
TBC1D25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45735
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14070721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06323
hsa-miR-4443	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.00885
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inositol phosphate dephosphorylation	GO Biological Process Annotations 2015	1.0	null
Perturb_14683_KO_Dpy30_SRP320666	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.25748
IZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19492
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.59734
REH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-3150b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
CRCGN017_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4305
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
CRCGN011_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0779
PMC11214527-mmc5.xlsx-NFATC3-gene_NFATC3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Sarcoma_SARC_TCGA-IE-A4EK-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE143643,GSE143644_3_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cingulate gyrus, retrosplenial part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26366
PFSK1	DepMap CRISPR Gene Dependency	1.0	17.9738
GSE143643,GSE143644_2_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.51176
Acute Myeloid Leukemia_LAML_TCGA-AB-2955-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36187
GTEX-T5JC-2526-SM-4DM6G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830717
Carcinoma, Hepatocellular	CTD Gene-Disease Associations	1.0	1.65621
Perturb_625_KD_IGF2BP3_SRP068523	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.10822
certolizumab pegol_homo sapiens_gpl570_gse33585	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lhx8_18509161_newborn_ovary_lof_mouse_gpl1261_gds3254	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.336508
glycerolipid metabolic process	GO Biological Process Annotations 2015	1.0	null
KYSE-150	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TUHR14TKB	DepMap CRISPR Gene Dependency	1.0	2.10459
Ectorhinal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22004
GSE128634,GSE128636_4_v_5_foxo1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Mesothelioma_MESO_TCGA-LK-A4NY-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4521181-oncsis201520x8.pdf-41-ZNF654_ZNF654	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98876398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76269
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE174406_2_v_1_lin28b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Oxaprozin_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0243256
BRD-K19103068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13361
CREB1	ENCODE Transcription Factor Targets	1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0012
GTEX-WFG8-2326-SM-3GILF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-A29371732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06761
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
idiopathic generalized epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.9696
GTEX-XLM4-0011-R8A-SM-4AT44	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10683
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
cellular lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K06208179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1032
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.919422
Rectum adenocarcinoma_READ_TCGA-CL-5918-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AZD2858_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0270252
BRD-K49577636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24056
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59179
NCI-H226	GDSC Cell Line Gene Expression Profiles	-1.0	-1.7795
GSE151829,GSE151831_3_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MZ1-PC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Disease by infectious agent	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	GO Molecular Function Annotations 2023	1.0	null
hsa-miR-1285	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
BRD-A01848933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30713
HCC1833	CCLE Cell Line Gene Expression Profiles	1.0	1.92943
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GDF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23044
AOB, mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11166
GSE173810_0_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31088
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.22233
SNU61	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33672
H3K27ac_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE148510_3_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150055_0_v_1_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13346
reticular nucleus of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.839985
BRD-K17765399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03675
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995632
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4822
hydrolase activity, acting on ester bonds	GO Molecular Function Annotations 2015	1.0	null
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.3958
BRD-K40367360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40127
Creutzfeldt-Jakob disease (variant)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17113
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH889	CCLE Cell Line Gene Expression Profiles	1.0	3.4046
glycerophospholipid metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K59437706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12701
stratum lacunosum-moleculare of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42885
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE114284_2_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
azaperone-3573	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ChIP_SETDB1_19884257	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33936
Perturb_8463_KO_IL10R2_ERP121014	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.49266
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27059
phosphatidylinositol metabolic process	GO Biological Process Annotations 2025	1.0	null
BRD-K59130962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08866
Perturb_8929_KD_CHD4/ARID1A_SRP350011	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.44943
GSE178255_3_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29677
BRD-K94580242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32463
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.45862
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Idiopathic generalized epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.25557
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13814
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_16592_KO_Trp53/Brca1_SRP186281	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.21161
Perturb_7597_KO_TENT3A/TENT3B_SRP400572	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-13.4637
GTEX-XPVG-1826-SM-4B64X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.888987
PANC 08.13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29725
Perturb_12182_KD_PALB2_SRP015361	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.2968
COCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Perturb_15765_KD_Msi2_SRP218930	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.04667
SKRC20	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46527
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19964
Perturb_13864_KD_KDM6B_SRP258989	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.4808
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.30247
CRCGN010_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23926
Vagina	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.586405
Perturb_7379_KD_SMG5_ERP122822	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.36481
KCL22	CCLE Cell Line Gene CNV Profiles	1.0	1.79067
BRD-K38791044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12681
diclofenac-2756	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-5311-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.1002
Perturb_7230_KD_UPF1LL_SRP295982	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.53521
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K05969019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40109
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879418
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCI-H1648	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.85704
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06815
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
KMT2A	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00335
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.63175
external part of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27298
U343	CCLE Cell Line Gene Expression Profiles	-1.0	-2.32573
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alcohol catabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916959
Perturb_8460_KO_IFNLR1_ERP121014	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.14176
H3K4me1_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K85513726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5071
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A6DV-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46137
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.29403
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.99477
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Perturb_15767_OE_Msi1_SRP218930	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.08155
Perturb_7957_KD_ZCCHC8_SRP222099	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.05861
GTEX-XLM4-2026-SM-4AT4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838149
Perturb_15673_KD_Hnrnpk_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.07016
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05516
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.91073
BRD-K14268329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31874
GTEX-SIU8-0826-SM-2XCDQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K96096022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44223
GSE145915_0_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
Perturb_12934_KD_DHODH_SRP340404	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.27837
DJM-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.13838
BRD-K46715415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09993
parbendazole-3881	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-R55E-0011-R8A-SM-2TC66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28806
GSE158182_5_v_7_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4773	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-K59960811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14234
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.2475
temporal lobe	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16264
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37777
GSE209598_1_v_2_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K16694974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15764
Tcf1_KO_GDS1473_307_mouse_Pancreatic islets	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.84645
A-Netherlands-602-2009(H1N1)_7Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.78066
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.1294
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06421
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.54505
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer 4 of CCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01318
hsa-miR-3065-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
GSE217101_0_v_1_mcph1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3914
SUPB15	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48554
dephosphorylation	GO Biological Process Annotations 2023	1.0	null
RCCFG2	DepMap CRISPR Gene Dependency	1.0	3.20831
BRD-K46839342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34769
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
heart_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.09235
GTEX-OHPM-0426-SM-3TW8V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863577
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_5859_KD_Lap2_SRP287033	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.39001
BRD-K28006645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05021
BRD-K93316985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04554
H3K4me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_2575_KD_LINE1_ERP011233	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.15582
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.10478
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
mantle zone of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.00279
phosphatidylinositol metabolic process	GO Biological Process Annotations 2023	1.0	null
Perturb_15758_KO_Adipor1_SRP339096	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.65486
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49074
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12997
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.064
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52589
Creutzfeldt-Jakob disease (variant)	GWAS Catalog SNP-Phenotype Associations	1.0	0.405958
GTEX-R55E-2526-SM-2TC6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.874089
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me1_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PRPF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29125
BRD-K76485827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23195
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.82961
alcohol metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC3573729-nl3042917_si_005.xlsx-OWY_Overlap_with_ANOVA-ORKIN_ZFX_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.094
Immune System Diseases	CTD Gene-Disease Associations	1.0	1.04794
NF2	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.04887
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.344
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886729
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
overnutrition	GWASdb SNP-Disease Associations	1.0	0.456788
BRD-K43261169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33082
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966571
GTPase activator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.129
organophosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-OHPN-0011-R11A-SM-2I5FM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913641
Perturb_14376_KD_MECOM_SRP276625	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.91063
protein modification process	GO Biological Process Annotations 2025	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94145457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31022
GTEX-UTHO-3026-SM-3GAFB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915568
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MQ-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.63495
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13921_KO_PPARGC1A_SRP314654	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.27863
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7165
CD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7503
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35682
LTBR_INHIBITION - 2 Days_GDS2005_729_mouse_Lymph nodes  (MG-430B)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K28467941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59522
PMC5527282-ncomms16041-s3.xlsx-M_LPS_-_gene_signature-Supplementary_Data_2_Full_gene_list_of_M_LPS_-_signatures_as_defined_in_figure_3_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Corticotropic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
17683608-TableS5	GeneSigDB Published Gene Signatures	1.0	null
Perturb_17550_KD_HMG20A_SRP354496	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.91992
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.454093
Perturb_8143_KD_NCBP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.93109
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13078
propidium iodide-5803	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.01099
phosphoric ester hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09683
H3K4me1_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2622
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.397
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3057
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	2.20841
GTEX-OXRK-0008-SM-3NB28	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.3163
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3646	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
Esmolol (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0195124
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFON-0526-SM-4LVLY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859043
GTEX-XPT6-2226-SM-4B66R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923137
GTEX-NPJ8-1426-SM-3MJHR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963755
GSE220914_2_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.878323
MELAS - Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes_Muscle - Striated (Skeletal) (MMHCC)_GSE1462	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.36088
BRD-K23467057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25952
CRCGN011_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.50915
Phagophore assembly site membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.522
Perturb_8398_KD_Safb_SRP180874	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.67742
Phosphoinositides metabolism	WikiPathways Pathways 2024	1.0	null
hsa-miR-3609	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
496100438_PCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.18687
LS-411N	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60407
ChIP_ESRRB_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988397
p3 part of the ZL core	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02725
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02488
hek293	HPA Cell Line Gene Expression Profiles	1.0	1.00781
betahistine-6611	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.83857
BRD-K14309706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27432
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00378
ME1	CCLE Cell Line Gene CNV Profiles	1.0	2.36488
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3116
INTS10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6004
myopia	GWASdb SNP-Phenotype Associations	1.0	0.494133
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56385
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.98824
Perturb_2586_KD_RORC_SRP066204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.4578
CRCGN013_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98522
BRD-K10704442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06645
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.91579
Adrenocortical carcinoma_ACC_TCGA-OR-A5JZ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.994714
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K89260735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05427
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.923732
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70P-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1325
BRD-K48407262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10668
PHB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83187
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
SNU449	DepMap CRISPR Gene Dependency	1.0	3.38187
BRD-K17482709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86192
protein modification process	GO Biological Process Annotations 2015	1.0	null
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.944466
Perturb_3532_KD_PTBP1_SRP310663	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.3847
GSE210580_0_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5264-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE159678_6_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SKNFI	DepMap CRISPR Gene Dependency	1.0	3.62724
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2912-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO-668	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_15994_KD_MIAT_SRP221619	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.34153
brain	HPA Tissue Gene Expression Profiles	1.0	2.24804
BRD-K77032979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62854
SOX2	ChEA Transcription Factor Targets	1.0	null
BRD-K74311661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29104
BRD-K86831676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07353
Fostamatinib (disodium hexahydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0229924
BRD-K72050003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13352
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4633-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE209598_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RU72-0011-R11A-SM-2TF6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64776
Accessory olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12938
cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2614
Mesothelioma_MESO_TCGA-TS-A7P8-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
cingulate gyrus, frontal part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.884879
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A87494167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0095
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.18954
BRD-A06232236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0726
Cholesterol	dbGAP Gene-Trait Associations	1.0	0.077409
ventromedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.869926
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.39472
Lung adenocarcinoma_LUAD_TCGA-55-6983-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906391
BRD-K06958718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52316
GTEX-Q2AG-3026-SM-48U1L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923694
Temporal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65238
GSE232631_4_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Joubert syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.389
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72468
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_12918_KD_C1orf186_SRP411666	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.73337
hsa-miR-520g	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
Perturb_6175_OE_Zeb1_SRP187711	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.91822
HARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25295
Perturb_8219_KD_XRCC6_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.00569
layer 4 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86521
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09605
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49074
hsa-miR-561	TargetScan Predicted Conserved microRNA Targets	1.0	0.065994
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10229
superior colliculus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.904347
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.97668
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30625
Perturb_8168_KD_GRSF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.03449
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051486
Prostate adenocarcinoma_PRAD_TCGA-CH-5752-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Metencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.14
Gonadal Disorders	CTD Gene-Disease Associations	1.0	1.08196
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28700379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2134
PMC12659123-12864_2025_12285_MOESM12_ESM.xlsx-Table_S12-Table_S12_Differentially_expressed_genes_after_SPI1_knockdown_SPI1	Rummagene Transcription Factor Associations 2026	1.0	null
Generalized epilepsy with febrile seizures plus 6	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.791
GSE174418,GSE174421_2_v_3_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.84237
Entorhinal area, medial part, dorsal zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04966
SNU620	CCLE Cell Line Gene CNV Profiles	1.0	1.37499
CME1	DepMap CRISPR Gene Dependency	1.0	4.35736
Hindbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.14
H3K27me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skeletal muscle satellite cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.843
preweaning lethality, incomplete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
MYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7557
cingulate gyrus, retrosplenial part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.964798
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52673
RAB3A_KO_GDS2483_700_mouse_Cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M6-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MUTZ8	DepMap CRISPR Gene Dependency	1.0	2.12394
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03381861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20507
diltiazem-6710	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAPK14_knockdown_139_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.85539
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.979096
nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
Perturb_11580_KD_BUD23_ERP119404	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.32639
Decitabine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0167196
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8236_KD_PTBP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.6224
GTEX-R55E-0011-R9A-SM-2TC6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54547
Inferior colliculus, external nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04966
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9825
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882509
posteroventral (inferior) parietal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25286
VDR-24763502-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_12296_KD_RORC_SRP066204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.77678
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
enzalutamide_homo sapiens_gpl570_gse44905	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4330	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
DB	DepMap CRISPR Gene Dependency	1.0	3.23093
Perturb_8886_OE_FOXM1_ERP109084	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.27482
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.77491
H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-X585-0011-R4B-SM-46MVH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875537
Perturb_5659_KO_SA2_SRP201842	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.86869
NCI-H522	GDSC Cell Line Gene Expression Profiles	-1.0	-1.57747
BRD-K84949119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04624
RAB3A_Mutation - D77G point mutation_GDS2483_697_mouse_Cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2371
hsa-miR-624	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
CAOV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.25268
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.985219
r7 part of the basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30216
cefotetan-4116	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K09972656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11945
Perturb_3561_OE_MYC/HHEX_SRP174604	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.78705
BRD-K98510376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8128
Perturb_8211_KD_SLTM_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.72389
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	1.47665
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE110178_1_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TUBGCP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08352
Perturb_8199_KD_CALR_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.0229
BRD-K57937572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09471
SLR26	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68361
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949087
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908253
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93791165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24855
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.31332
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.921512
BRD-K64449549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33841
Rutin (trihydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0278079
Nrf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	94.1665
Perturb_2717_KO_TET1_SRP110516	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.413
Perturb_4761_KO_DLG2_SRP315088	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.7773
hsa-miR-3973	TargetScan Predicted Conserved microRNA Targets	1.0	0.123298
GTEX-NPJ8-0011-R9a-SM-2YUN5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891994
Postlarva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.598
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRN-0226-SM-2I5EJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.52348
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.596225
In situ melanoma of skin_Epidermis_GSE4587	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.47894
protein tyrosine phosphatase activity	GO Molecular Function Annotations 2015	1.0	null
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.51565
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	1.00322
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.27606
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.964525
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K94903598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01417
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.40592
BRD-A07944983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30929
SNU503	DepMap CRISPR Gene Dependency	1.0	2.36156
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.962598
GTEX-WL46-0926-SM-3LK7T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Brain Lower Grade Glioma_LGG_TCGA-HT-7603-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-V955-0926-SM-4JBJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903725
hsa-miR-642b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.35966
BRD-K39548949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31834
GSE226316_4_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_8161_KD_SF3B1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.09296
GSE126463_5_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ovary	GTEx Tissue Gene Expression Profiles	1.0	0.926856
CAL-85-1	GDSC Cell Line Gene Expression Profiles	1.0	1.76206
Dapagliflozin ((2S)-1,2-propanediol, hydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0235509
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Posterior limiting nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03171
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-645	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Accessory olfactory bulb, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52774
GSE192513,GSE192515_2_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_10629_KO_Fnc_SRP161615	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.49791
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1156
Perturb_13797_KO_Phc1_SRP096055	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5984-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63487554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61698
lipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1385	CCLE Cell Line Gene Expression Profiles	1.0	1.68637
thyroid_5d	HPA Tissue Sample Gene Expression Profiles	1.0	1.26684
dexpropranolol-3553	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933566
GSE126127_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SETDB1	ChEA Transcription Factor Targets	1.0	null
km3	HPA Cell Line Gene Expression Profiles	-1.0	-0.841361
BRD-K68705041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17985
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29103
protein tyrosine phosphatase activity	GO Molecular Function Annotations 2023	1.0	null
SLX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39191
GSE174383_2_v_0_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE101112_0_v_2_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE189683_3_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
outer CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.957098
BRD-K26195700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00264
SW1271	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39812
KMS11	DepMap CRISPR Gene Dependency	1.0	2.93959
GTEX-TSE9-2626-SM-4DXV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
tonsil_8a1	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.17336
SFTPC_KO_GSE35989_48_mouse_lung (type II cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_15061_OE_Trp53_SRP345823	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.34773
Phospholipid metabolism	Reactome Pathways 2024	1.0	null
PANC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47409
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cardiac myofibril	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.515
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
glycerophospholipid biosynthetic process	GO Biological Process Annotations 2023	1.0	null
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
inner CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1989
KURAMOCHI	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A4BB-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K65166009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30316
GCT	DepMap CRISPR Gene Dependency	1.0	3.98299
GSE146072_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178255_3_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Doxorubicin (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226788
TMEM37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26425
NCIH1155	CCLE Cell Line Gene Expression Profiles	1.0	1.56204
glycerolipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3467-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RUSQ-0626-SM-2TF5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.24138
Entorhinal area, medial part, ventral zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17831
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.25121
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.32751
GTEX-XMD1-0011-R9A-SM-4AT49	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5352
GTEX-N7MS-0011-R8a-SM-2YUMK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1511
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.062873
BRD-K41709602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8626
Perturb_14588_KD_TCF7L1_SRP094619	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.27142
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947666
GSE127790_4_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R53T-0926-SM-3GADH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GSE112714_2_v_0_ctnnb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67904
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906391
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
creutzfeldt-jakob syndrome	GAD Gene-Disease Associations	1.0	null
Perturb_15213_KD_BRD4_SRP255722	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.14164
layer 1 of RSC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17162
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53845
PBX1-22567123-OVCAR3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K94833531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09895
GSE151119_2_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OSC-19	COSMIC Cell Line Gene Mutation Profiles	1.0	null
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
NDUFA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81195
BRD-K02159857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06932
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.59203
urinarybladder_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.09959
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Folic Acid	CTD Gene-Chemical Interactions	1.0	null
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09247
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34522
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-4.10703
HTK	CCLE Cell Line Gene Expression Profiles	-1.0	-1.91659
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K09250647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32862
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4499
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
ribostamycin-3444	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84623
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10641274-mmc2.xlsx-FOXK1_Insulin-ENSEMBL_FOXK1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T5JC-0011-R2A-SM-32PLZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08772
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31649
Fetal Death	CTD Gene-Disease Associations	1.0	1.66231
CRCGN013_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16346
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04382
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.57477
superficial stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.92481
BRD-K05250921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13865
NCIH146	CCLE Cell Line Gene Expression Profiles	1.0	1.52528
BRD-K19766710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24776
STK38L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18371
mediodorsal nucleus of thalamus_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.63016
amygdaloid complex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02784
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.03493
Perturb_8759_KO_SETDB1_SRP141213	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.40073
BRD-K75869095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50503
Cardiovascular Diseases	CTD Gene-Disease Associations	1.0	1.03419
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.854024
phosphatase activity	GO Molecular Function Annotations 2015	1.0	null
E2F1	ChEA Transcription Factor Targets	1.0	null
cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE174383_2_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4522	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE174383_1_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_4759_KO_DLG2_SRP315088	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.21006
PMC7403583-41598_2020_69884_MOESM2_ESM.xlsx-Sheet1-Supplementary_Table_1_Differentially_Expressed_Genes_FDR_q_0_05_in_U2932_ROCK2_KD_vs_Scrambled_shRNA_Constrols_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ChIP_RCOR2_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
rimexolone-5517	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6206_KD_UBF_SRP188861	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.85144
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96534
GTEX-R55D-1526-SM-48FEJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Supraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76037
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6UY-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein tyrosine phosphatase activity	GO Molecular Function Annotations 2025	1.0	null
Accessory olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16412
GTEX-QDT8-0011-R8A-SM-32PKE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86314
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
equilin-5255	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IV, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.923409
SR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.18763
GSE196671_5_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23531
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
GSE124048,GSE124067_1_v_0_irf6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Loeys-Dietz syndrome 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.12663
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.938255
abnormality of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.112305
smallintestine_4b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.983129
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62196
subgranular zone of caudal dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24221
parasubicular cortex (parasubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.222
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02471
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923828
BRD-K00231307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26024
496100555_TCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.53061
639-V	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-N7MT-0011-R4a-SM-2I3G9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841213
Apalutamide_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0223225
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4931
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K90527476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49123
artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07839
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.48059
paromomycin-4595	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NANOG-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BHT-101	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4708-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K69817449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10565
L-Eflornithine (monohydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0374308
tonzonium bromide-5678	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6383
NUMA1	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-T5JC-0011-R9A-SM-32PLV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982422
Weight Loss	CTD Gene-Disease Associations	1.0	1.46832
BACH1	ENCODE Transcription Factor Targets	1.0	null
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32624
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDVJ-1326-SM-48U1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844308
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04299
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K12571248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07857
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCAS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48078
BRD-K53772256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12893
GSE131161_3_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62547690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18285
Primary somatosensory area, barrel field, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30711
GTEX-WVLH-0011-R6A-SM-3MJFZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927104
Perturb_8158_KD_HNRNPLL_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.58309
H3K27me3_iPS-20b	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Retrosplenial area, lateral agranular part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00381
ES5	DepMap CRISPR Gene Dependency	1.0	2.49361
LIVF001-005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.348
TRIM28-17542650-NTERA2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Talc_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.030698
BRD-K12555854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4436
abnormal eye physiology	GWASdb SNP-Phenotype Associations	1.0	0.192766
GSE214823,GSE214824_6_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5379
r10 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4098
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K13204142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40184
Prion disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.517
Inositol phosphate metabolism	KEGG Pathways 2026	1.0	null
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23973
GTEX-WH7G-0008-SM-4LVNM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.871144
BCCIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20965
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47243
SOX17	ChEA Transcription Factor Targets	1.0	null
Ventral anterior-lateral complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24896
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20965
Acute Myeloid Leukemia_LAML_TCGA-AB-2971-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.8564
Atrophy	CTD Gene-Disease Associations	1.0	1.66706
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.826833
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1048	GDSC Cell Line Gene Expression Profiles	1.0	1.73023
eye disease	GWASdb SNP-Disease Associations	1.0	0.102948
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.37415
BRD-K69751974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41698
Perturb_8973_KD_RBL1_SRP218370	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.49959
primary motor cortex (area M1, area 4)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.033
EZH2	ENCODE Transcription Factor Targets	1.0	null
GTEX-QCQG-0008-SM-48U2G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9137
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU81	CCLE Cell Line Gene Expression Profiles	-1.0	-2.41006
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
SOX17-20123909-XEN-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ventral nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82768
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.86645
IM-95	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75151
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20463
MXI1	ENCODE Transcription Factor Targets	1.0	null
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.892312
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149903_4_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
brain disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
HS-445	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7692-01A-12R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
superficial stratum of r5Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.96219
Choline	CTD Gene-Chemical Interactions	1.0	null
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27412
ventral posteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.65562
cone-rod dystrophy 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.3519
BRD-K40941329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05192
HT29	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51164
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K35119180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29367
Posterolateral visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.1212
GSE198165,GSE198166_7_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K24070365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21771
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906391
Perturb_3791_KD_KCNK1_SRP057613	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.78748
Perturb_13490_KD_Ncor1_ERP132013	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-14.6881
HT55	COSMIC Cell Line Gene Mutation Profiles	1.0	null
zfx_17448993_embryonic_stem_cell_lof_mouse_gpl1261_gds2718	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.717198
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
THOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04222
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P4PQ-0226-SM-2S1NK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27857
Perturb_39_KD_ATRX_SRP308220	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.76912
Perturb_8418_KO_Yap1/Wwtr1_SRP143461	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.07072
Posterior complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.93055
GTEX-X4XY-1726-SM-46MVO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
PMC11058205-42003_2024_6202_MOESM5_ESM.xlsx-Data2c_CEBPA_ChIP-Unnamed_9_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
MAML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39479
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965194
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4116-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126127_0_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K94790210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44992
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.20389
GTEX-OXRK-0626-SM-2HMJ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836231
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23971
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5876-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13532
Prostate adenocarcinoma_PRAD_TCGA-M7-A723-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6141_OE_PPP1CA/PPP1R8_SRP118980	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.8019
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31854
GJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43156
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CA46	GDSC Cell Line Gene Expression Profiles	1.0	1.69089
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164529_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RU72-2926-SM-2TF66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16842
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30943
Autophagosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.691
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.55378
IDRA-21	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.035
BRD-K97445906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04805
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6131
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SF539	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.830227
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Phosphatidylinositol signaling system	KEGG Pathways 2026	1.0	null
KDM5B_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1009
Generalized epilepsy with febrile seizures plus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.473
CDK2_knockdown_146_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.04127
Perturb_8087_KD_EIF4G2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.12374
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
protein modification process	GO Biological Process Annotations 2023	1.0	null
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50729
BRD-K57830670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97229
CTBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07703
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.67123
DMS79	CCLE Cell Line Gene Expression Profiles	1.0	1.60869
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.44768
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998624
Lung adenocarcinoma_LUAD_TCGA-50-5051-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
zimeldine-4609	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOSL1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01277
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.852314
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4276
SAP30	ENCODE Transcription Factor Targets	1.0	null
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901927
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9423
NRF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A73618687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13671
Edema	CTD Gene-Disease Associations	1.0	1.40232
GSE127790_10_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
piriform cortex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.976964
HPAF-II	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18978
Cerebral lobe	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
r10 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.84425
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840229
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.17029
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
Dentate gyrus, granule cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21046
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.96389
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26982
Adrenocortical carcinoma_ACC_TCGA-OR-A5LC-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW954	DepMap CRISPR Gene Dependency	1.0	3.16519
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41917
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
monobenzone-6713	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NPJ8-0326-SM-2D7VV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Nervous System Malformations	CTD Gene-Disease Associations	1.0	1.25183
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25138
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7920-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K57650037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24375
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Apical tubulobulbar complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.936
GSE122215,GSE122217_5_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95385525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0435
HPBALL	CCLE Cell Line Gene Expression Profiles	-1.0	-1.79172
supramarginal gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0388
TC32	DepMap CRISPR Gene Dependency	1.0	2.00787
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4860-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7941712-40478_2021_1135_MOESM12_ESM.xlsx-Table_S4D_DEG_ST-EPN-RELA-Unnamed_6_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal respiratory system morphology	GWASdb SNP-Phenotype Associations	1.0	0.141256
temporal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.55326
HCC70	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.11641
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.96437
THP1	CCLE Cell Line Gene CNV Profiles	1.0	1.36829
small molecule catabolic process	GO Biological Process Annotations 2015	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70E-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.78775
NAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27535
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14295
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.91084
MRPL57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52064
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.09908
Bipolar Disorder_frontal cortex_GSE5389	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.66331
GSE144500_8_v_2_ventx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.4425
Perturb_2367_KO_CGAS_ERP131756	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.35336
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
inositol phosphate metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K35128023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57976
BRD-K99660943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75234
brain	GTEx Tissue Gene Expression Profiles	1.0	1.46429
BRD-K83815065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28418
SRSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18919
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
CRCGN015_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66455
H3K4me1_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.00754
glis3_19805515_embryonic_pancreas_lof_mouse_gpl1261_gds3812	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.20331
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8833
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_17338_KO_Mageb4_SRP259999	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.44042
SW1783	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041287
APLP2_KO_GDS4414_536_mouse_adult cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Levobupivacaine (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0189949
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989059
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE100316_3_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4763_KO_DLG2_SRP315088	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.50476
BRD-K52232548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03941
GSE232631_5_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K26748243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20674
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
FAM236B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20089
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875497
GSE179974_3_v_5_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44415
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12318
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23702
SHP-77	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Methionine	CTD Gene-Chemical Interactions	1.0	null
H4K91ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02088
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15403_KD_AR_SRP377764	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Liver hepatocellular carcinoma_LIHC_TCGA-GJ-A6C0-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE192513,GSE192515_1_v_0_atg16l1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K77832645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12436
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16541
BRD-K75130046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67065
JUN-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
KIF13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29552
GTEX-T6MN-2726-SM-4DM77	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835174
Acute Myeloid Leukemia_LAML_TCGA-AB-2959-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GSE180185_4_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
prion disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887038
Ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
posterior group of nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02109
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.98751
GTEX-XMD3-0008-SM-4AT4V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863107
BRD-K15028515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7109
pituitary	GTEx Tissue Gene Expression Profiles	1.0	1.37508
JHOS-4	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.11641
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GP-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral group of nuclei, left, dorsal division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40388
NCI-H1770	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19237
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
not applicable_cell type comparison_GSE49439_365_human_podocytes and progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21767
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20918
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
short insular gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.970593
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09683
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23281
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K50240676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10356
NCIH1869	DepMap CRISPR Gene Dependency	1.0	2.02718
SP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6274
BRD-K14723547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85281
Perturb_15536_KO_Ezh2_SRP220248	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
periventricular stratum of AStr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05877
BRD-K33805386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1217
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47835
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.1627
GTEX-U8XE-0826-SM-4E3J1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930317
Acne_Sebocyte_GSE10432	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.22545
Synthesis of PIPs at the late endosome membrane	Reactome Pathways 2014	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MS-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69594935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03894
BRD-K93752373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01016
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04917
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.62805
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7884-01B-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1978
Perturb_2872_Mut_KRAS_SRP404927	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.23872
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13359
H3K27me3_CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-3919	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K96925976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14402
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.13423
BRD-K89584810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25275
BRD-K22449045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61837
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A40504327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29711
Perturb_8108_KD_HNRNPM_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.83398
increased mean corpuscular hemoglobin concentration	IMPC Knockout Mouse Phenotypes	1.0	null
GSE114284_1_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
anterior group of nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19025
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Prostate adenocarcinoma_PRAD_TCGA-J4-A67L-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56133
Pemigatinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0271477
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
KCL22	CCLE Cell Line Gene Expression Profiles	1.0	1.67316
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.829461
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12800118-41698_2025_1217_MOESM1_ESM.pdf-6-JDP2_JDP2	Rummagene Transcription Factor Associations 2026	1.0	null
CHP-126	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.992518
SW1710	GDSC Cell Line Gene Expression Profiles	-1.0	-2.96762
TIG3TD	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6661
amygdaloid complex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15425
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8162-01A-21R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE88819_11_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_9976_KD_G3BP2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.45868
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LA-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87967738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11931
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
SNUC5	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80988
Perturb_14735_KD_ADAR1_SRP250165	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.89177
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29725
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AKT1_knockdown_141_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.22331
BRD-K10010414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20346
NAD	HMDB Metabolites of Enzymes	1.0	null
19658189-TableS4	GeneSigDB Published Gene Signatures	1.0	null
delavirdine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84072
hsa-miR-575	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-K83395537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4527
r5 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.16075
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26A-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199255,GSE199356_6_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_DN4_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
creutzfeldtjakob	GeneRIF Biological Term Annotations	1.0	null
phosphatidylinositol biosynthetic process	GO Biological Process Annotations 2023	1.0	null
RAP1GAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07396
GSE186810,GSE186813_7_v_1_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dephosphorylation	GO Biological Process Annotations 2015	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	2.13888
BRD-K15779027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08141
BRD-K61494613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22772
GTEX-NPJ7-0011-R11A-SM-2I3E8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29497
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QV44-0526-SM-2S1RE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K44975377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1255
GSE153663,GSE153664_1_v_0_zeb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.02883
COV318	DepMap CRISPR Gene Dependency	1.0	2.27594
Lung squamous cell carcinoma_LUSC_TCGA-22-4594-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.39142
Hs-578-T	GDSC Cell Line Gene Expression Profiles	-1.0	-2.39167
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.43522
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-Q734-0126-SM-48U1E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85604
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0876
MKN45	DepMap CRISPR Gene Dependency	1.0	10.4674
Perturb_4905_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.49275
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0687
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08458
Epirubicin (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0220795
refractive error	GWASdb SNP-Disease Associations	1.0	0.417452
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral group of nuclei, left, ventral division	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.824643
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
tribenoside-3507	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_9080_KD_FGFRL1_SRP319532	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.40575
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.845989
ZNF384	ENCODE Transcription Factor Targets	1.0	null
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.3583
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86547
GSE210580_3_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KIJK	CCLE Cell Line Gene Expression Profiles	1.0	2.31358
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.8905
GSE149903_3_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46G-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.45631
Brain Lower Grade Glioma_LGG_TCGA-HT-7610-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
r5 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13353
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-NB4-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_NB4_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
Peretinoin_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0180042
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3662	TargetScan Predicted Conserved microRNA Targets	1.0	0.119151
BRD3OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15808
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.930042
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36772
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6467-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221020,GSE221023_2_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOSL1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI Metabolism	Reactome Pathways 2014	1.0	null
phosphatidylinositol biosynthetic process	GO Biological Process Annotations 2025	1.0	null
PPDPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08352
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
19074828-TableS4	GeneSigDB Published Gene Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gill filament	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.535
GSE223334_1_v_2_bcl11b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218580_1_v_4_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14548
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
SETDB1-19884257-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
r3 part of parvicellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02268
GTEX-X585-0011-R11B-SM-46MUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36317
Metabolism	Reactome Pathways 2024	1.0	null
GSE214823,GSE214824_0_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25945
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895938
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00258
Inflammation	CTD Gene-Disease Associations	1.0	1.55995
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_8924_KD_LINC01133a_SRP320645	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.25197
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.35905
Paraplegia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.929781
BRD-K76951133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15223
Kidney Chromophobe_KICH_TCGA-KN-8428-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cyproterone-3545	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IST-SL1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.59026
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16004_OE_HOXA13_SRP107176	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.72249
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
ZNF28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18689
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Trametinib (DMSO_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0334694
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.40704
Posterolateral visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.77364
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20182
neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.32373
brain disease	GWASdb SNP-Disease Associations	1.0	0.253146
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K76431854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04488
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.995913
GSE164529_0_v_2_tamoxifen_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_8141_KD_MAGOH_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.17437
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
GSE160293_2_v_4_celf6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_4312_KD_SMRT_ERP126775	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Radotinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.017016
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04958
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.950931
BRD-K62370517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04815
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
zbtb7b_19734230_cd8_p14_memory_lof_mouse_gpl1261_gds3566	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.80435
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OB olfactory fiber layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54203
PAX3-FKHR-20663909-RHABDOMYOSARCOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13138
BRD-K21196859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10827
Phosphatidylinositol 3-kinase complex, class II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.641
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K10017294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0691
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062771
Basal tubulobulbar complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.184
CRCGN014_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21601
r6 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14346
BRD-K79355381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44746
practolol-3204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K27889081	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12402
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A6DW-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ventral posterior complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.28337
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11259
Perturb_10718_KO_Hck_SRP340501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.731
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.97787
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
ECC10	CCLE Cell Line Gene CNV Profiles	1.0	1.49088
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.36486
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RQ-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.844286
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87464
hsa-miR-3148	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.72696
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
cholesterol	GAD Gene-Disease Associations	1.0	null
ONCODG1	CCLE Cell Line Gene CNV Profiles	1.0	2.00166
Perturb_12058_KO_Stat5a/Stat5b_SRP012574	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.7957
granular layer of caudal dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16391
Perturb_1893_Mut_Trem2_SRP173901	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.85344
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)HAAvirmut_1day-MOI-10^4_None_GSE37572	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.04512
Perturb_10944_KO_Mtdh_SRP080807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.37741
estradiol-5205	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10245467-mmc3.pdf-140-RBSN_RBSN	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K22139757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96356
cytosol	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-4519	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE174383_4_v_0_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	3.95353
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
hsa-miR-630	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE234289_3_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GPR180	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08915
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
cholesterol, ldl	GAD Gene-Disease Associations	1.0	null
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04648
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FXR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21685
MAPK1_knockdown_145_GSE31912	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.88564
E2F6	ENCODE Transcription Factor Targets	1.0	null
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4135
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.9588
GSE143643,GSE143644_1_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
myopia	GWASdb SNP-Disease Associations	1.0	0.58076
GTEX-U8XE-1226-SM-4E3HN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.935294
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13428
GSE178255_5_v_6_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Alzheimer's Disease_Entorhinal cortex_GSE5281	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.51065
BRD-K44078665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.60896
CTBP2	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6ME-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ERBB2_druginhibition_6_GDS2139	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-3.14536
BRD-K15714104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25197
biological_process	GO Biological Process Annotations 2015	1.0	null
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.891826
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.17067
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82991
Lymphnode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.964454
PC3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33807
Body Weight Changes	dbGAP Gene-Trait Associations	1.0	0.356527
Ebolavirus(EBOV)_3day_Splenocytes_19683682_GSE17509	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.4708
496100504_TCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02114
BRD-K86584551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39582
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE196540,GSE196542_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JHH4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57245
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A51B-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.095184
BRD-K17152303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34102
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4718
DV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49074
mantle zone of r10BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22996
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44824
GSK3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48169
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.714661
BRD-K06997715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08851
BRD-K57502201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25376
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE197948_2_v_0_atp7b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_14118_KD_RPS6KB2_SRP187713	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.75723
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04289
PMC10594727-13062_2023_428_MOESM14_ESM.xlsx-Sheet1-PPARD_PPARD	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K36156445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09648
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
BRD-K47804666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3716
BRD-K37584671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09931
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8191_KD_ILF2_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.63912
Perturb_14233_KD_PABPN1_SRP326835	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.6653
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873563
BRD-K73357010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56138
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211177,GSE211178_9_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI H226	BioGPS Cell Line Gene Expression Profiles	1.0	0.836057
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
body weight changes	GAD Gene-Disease Associations	1.0	null
Posaconazole_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.037099
Acute Myeloid Leukemia_LAML_TCGA-AB-2975-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE214823,GSE214824_3_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM120A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34478
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hepatitis	CTD Gene-Disease Associations	1.0	1.23837
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76691746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07505
BRD-K46348476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03514
hsa-miR-4792	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE199255,GSE199356_3_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NUGC2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70697
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43527
GTEX-U4B1-1926-SM-3DB9E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930435
GTEX-QEG5-1226-SM-447AR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
HCC1195	CCLE Cell Line Gene CNV Profiles	-1.0	-2.30162
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50474387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58806
NFKB1	JASPAR Predicted Transcription Factor Targets	1.0	null
Perturb_8239_KD_RECQL_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.47581
GSE232631_5_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.98694
ABCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51459
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21993
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32012
Precancerous Conditions	CTD Gene-Disease Associations	1.0	1.059
External cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02268
phosphorylated carbohydrate dephosphorylation	GO Biological Process Annotations 2015	1.0	null
CRCGN013_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0285
hilus of the DG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2166
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-N7MT-1026-SM-3TW8T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965781
bone marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.328994
preoptic region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.831278
CRCGN012_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12124
BRD-K27028848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07214
phosphatidylinositol monophosphate phosphatase activity	GO Molecular Function Annotations 2025	1.0	null
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K08036779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49173
Ventral premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3826
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
Seasonal affective disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
GSE210885_5_v_6_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TP53_01_68	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.57146
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04374
Parasubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71435
Fatty Liver	CTD Gene-Disease Associations	1.0	1.88192
18537972-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K04969760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1877
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49099
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10079
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85173
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8272
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58828
Perturb_8120_KD_SF1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.93988
GSE171175,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
Entorhinal area, medial part, ventral zone, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53517
BRD-K36353158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10206
ondansetron-6270	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ranolazine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0165725
shell part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63918
GTEX-TMZS-0008-SM-47JWM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89831
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
Oligodendrocyte_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
hsa-miR-1243	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2135
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RU72-0011-R8A-SM-2TF61	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875489
BRD-K59831227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06526
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5397
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08882
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5153-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178255_5_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Developmental and epileptic encephalopathy 53	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.628
BRD-K55877261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67709
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56893290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10372
Avian pallium	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MYC	ENCODE Transcription Factor Targets	1.0	null
PMC9601604-NIHMS1841143-supplement-SuppTable-2.xlsx-FOXO3-specific_targets-FOXO3-specific_targets_1218_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_3937_KO_DBC1_SRP371865	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.29467
BRD-K76588804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73022
Perturb_1559_KO_Ticam2_SRP056432	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.56059
dephosphorylation	GO Biological Process Annotations 2025	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
Perturb_12610_KD|Mut_Ezh2|Jak2_SRP075921	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.56853
r7 part of parapyramidal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.83857
BRD-K89801935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86994
Perturb_6621_KO_NEUROD1_SRP388830	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.08644
GSE207832_1_v_0_usp22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8639-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04583
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.951423
KANSL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49971
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.8
Perturb_15486_KD_SIM2_SRP218853	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.49257
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cefalotin-2517	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3916	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSK3A_KD_GDS4305_180_human_MOLM-14 myeloid leukemia cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE95685_2_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE188870,GSE188871_4_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234289_4_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ventrolateral part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49556
GTEX-T6MN-1126-SM-4DM71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K96023136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.186
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.07947
Fatty Liver, Alcoholic	CTD Gene-Disease Associations	1.0	1.20031
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.05704
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Neuromuscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
BRD-K26479796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78294
cyproterone-6806	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K10157835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75526
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Variant Creutzfeldt-Jakob disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.673
EPHA4_drugactivation_229_GSE26523	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.13095
BRD-K95666495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40473
Poisoning	CTD Gene-Disease Associations	1.0	1.61667
GSE180951_1_v_4_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AP2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45409
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7897-01A-21R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K68364310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74355
BRD-K19168437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89752
NCIH209	CCLE Cell Line Gene CNV Profiles	1.0	1.52142
TRIM28	ChEA Transcription Factor Targets	1.0	null
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.77927
BRD-K34761198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06546
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
Autosomal recessive centronuclear myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.714
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.93198
LS-411N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
central amygdaloid nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30711
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02321
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Parasubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.40556
hsa-miR-4676-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GTEX-PLZ4-0726-SM-2TC6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09784
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.69424
intermediate part of r7B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44982
PMC12670081-mct-24-0704_supplementary_table_s10_suppst10.xlsx-Supplementary_Table_S10-Supplementary_Table_S10_Differential_expression_of_TFCP2-rearranged_RMS_Vs_Other_RMS_FC_3_padj_0_01_TFCP2	Rummagene Transcription Factor Associations 2026	1.0	null
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.39073
OCUM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33219
neurological	GAD High Level Gene-Disease Associations	1.0	0.293278
BRD-K29301364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80576
GSE114553_0_v_1_lhx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5465
HCC2814	CCLE Cell Line Gene Expression Profiles	-1.0	-2.37307
chlorogenic acid-3282	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN011_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92365
sulfanilamide-6810	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Suprageniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02725
EGR-1_KO_GDS3607_525_mouse_Retina - 30 Days (POST-NATAL)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE123372,GSE123373_1_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K85475457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66327
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.69397
CRCGN016_MCF10A.WT.HP_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35782
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.882189
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841196
Lung adenocarcinoma_LUAD_TCGA-91-6828-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE121824,GSE121826_0_v_8_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03813
Brain Lower Grade Glioma_LGG_TCGA-FG-6690-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.80818
GSPT1	MSigDB Cancer Gene Co-expression Modules	1.0	null
PLC/PRF/5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.827016
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.3777
lateral posterior nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20107
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Weight Gain	CTD Gene-Disease Associations	1.0	1.07269
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15857
cotinine-5246	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XXEK-1226-SM-4BRUY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Adrenocortical carcinoma_ACC_TCGA-OR-A5K1-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.66491
Perturb_15672_KD_Hnrnpc_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.63699
central nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
Perturb_17642_OE_YAP_SRP298391	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.34037
Perturb_16954_KO_MLX_SRP183152	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.18956
Perturb_1740_KO_Usp15_SRP290189	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.76496
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.89544
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K27320944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37031
tilorone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0648
GSE126127_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29419
hsa-miR-2278	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Entorhinal area, medial part, dorsal zone, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62738
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.03098
JUND-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
GSE155031_5_v_0_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5580-01A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW1463	GDSC Cell Line Gene Expression Profiles	-1.0	-2.00574
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4302	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Beta-D-Fructose 2-phosphate	HMDB Metabolites of Enzymes	1.0	null
hsa-miR-4698	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K33462260	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01543
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
CHAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76426
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3073
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.226607
thalidomide-5990	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.944451
GSE158853_0_v_1_hmgcs2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49074
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.905015
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.829583
ventral lateral nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05093
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.956299
CRCGN017_MCF10A.TP53.M_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2267
layer 1 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15767
TIGD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06837
BRD-K23694339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13848
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K41645779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50965
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.63465
GSE200673,GSE200691_1_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K89595887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04026
18516279-GeneList	GeneSigDB Published Gene Signatures	1.0	null
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.67107
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21066
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31153
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K60192542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11622
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CHUK	MSigDB Cancer Gene Co-expression Modules	1.0	null
NCIH211	CCLE Cell Line Gene Expression Profiles	1.0	1.42451
PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_15_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_10185_KD_ARNT1/3_SRP337185	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.6637
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	1.0	null
RH28	DepMap CRISPR Gene Dependency	1.0	2.99565
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2385
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-570	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
GTEX-UTHO-3126-SM-3P5ZB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908586
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventral premammillary nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48596
autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.321181
GTEX-R55F-1226-SM-2TF59	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905178
GSE228894_0_v_1_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.121791
ChIP_H3K36me3_18692474_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE190316,GSE190324_1_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174383_1_v_0_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-203	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Perturb_12704_KO_LIPA_SRP310406	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.75685
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19563
dorsal motor nucleus of the vagus (vagal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.827043
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9038
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
cell part	GO Cellular Component Annotations 2015	1.0	null
Thymic Carcinoma_Thymus_GSE2501	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.46042
Lung squamous cell carcinoma_LUSC_TCGA-39-5034-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lipid modification	GO Biological Process Annotations 2015	1.0	null
PECAPJ34CLONEC12	CCLE Cell Line Gene CNV Profiles	-1.0	-2.23352
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64932
Primary somatosensory area, barrel field	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39034
Osimertinib (mesylate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0237391
BRD-K18084996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13453
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56844
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
NRF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.79099
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.036459
LRRK2_mutant_32_GDS4400	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.80128
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5456-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.03288
GTEX-RWS6-0526-SM-4GIAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934172
PARP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15498
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09523
BRD-K94751306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82787
OCI-AML3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49074
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37525
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10355_KD_SHQ1_SRP154234	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.7673
ZMAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22907
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5LR-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tamoxifen_homo sapiens_gpl570_gds4095	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
GSE254848_4_v_3_ptges_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pyridoxine-5813	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K27540772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12805
Perturb_8214_KD_SRSF5_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.77987
Telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.1927
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SU-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_15394_KD_RRM2_SRP155857	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.52021
POLR2AphosphoS5_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MXD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16959
Perturb_6435_KD_HOXA10AS_ERP131886	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	17.0953
Perturb_5089_KO_Sall4/Sall1_ERP014607	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.27763
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
propylthiouracil-4157	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-665	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GTEX-RNOR-0011-R9A-SM-2TF52	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55986
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.33204
hsa-miR-4451	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE211989_0_v_1_nlrc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GK_KO_GDS1555_127_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88155
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36622
GTEX-T2IS-0011-R2A-SM-32QPF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921564
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_16_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20801
BRD-A28219573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90249
LY-2584702 (tosylate salt)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0149382
r7 part of cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.68919
BRD-K61681480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26372
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.88884
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120370_0_v_6_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Canagliflozin_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0179832
Ouabain (Octahydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0140847
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
intermediate stratum of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06524
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826811
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040717
middle cerebral artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.593247
GSE248668_1_v_0_atxn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25199508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22924
SUDHL1	CCLE Cell Line Gene Expression Profiles	1.0	2.32861
BRD-K71647210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8551
Perturb_3913_KD_Y14_SRP118481	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38597
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1555
Smooth muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939333
BRD-K22390389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77576
Phosphatidylinositol 3-kinase complex, class III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.239
GSE174751_0_v_1_postn_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.869942
Brain Lower Grade Glioma_LGG_TCGA-HT-7694-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mad-Max complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.746
GSE118794_2_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040149
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20055
NELFA-20434984-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09726
HNF4A-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.92118
superficial stratum of PaS (cortical plate/marginal zone)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29733
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.862188
GTEX-PWO3-0011-R8A-SM-2I5GD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990894
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915439
parasubiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29733
BRD-K36445086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21994
Perturb_11834_KO_Rilp_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.50325
N1E-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.042
FOS_01_99	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	7.76789
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5833
LYNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12781
BRD-K55800245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09648
Anterior cingulate area, ventral part, 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12901
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-RUSQ-0826-SM-47JWW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.881689
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.6201
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0896
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05626
Liver Cirrhosis, Experimental	DisGeNET Gene-Disease Associations	1.0	null
Amygdala	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.928286
CHD2	ENCODE Transcription Factor Targets	1.0	null
Cleft Palate	CTD Gene-Disease Associations	1.0	1.10388
COLO-678	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A41916216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06702
CRCGN012_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.95926
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NQ-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.13499
NCI-H1876	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.05386
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30425
GSE76771_2_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100462_PCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.31844
hippocampus (hippocampal formation)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.868882
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K23481525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46664
Tubulobulbar complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.029
dexamethasone_rattus norvegicus_gpl1355_gse29912	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.16541
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0615
hsa-miR-4516	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Brain Lower Grade Glioma_LGG_TCGA-HT-7874-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFX-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34105
GSE188870,GSE188871_4_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
creutzfeldt-jakob disease	GWASdb SNP-Disease Associations	1.0	1.39396
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K26976202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03301
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.13355
r8 part of the paragigantocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76281
T3M3	DepMap CRISPR Gene Dependency	1.0	3.78214
BRD-K27885385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46368
SUP-HD1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ISTMES2	CCLE Cell Line Gene CNV Profiles	1.0	2.14026
Perturb_691_KD_PTPN6_SRP275597	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.81063
EHMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30194
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32427
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.40471
GTEX-X4EP-3226-SM-3P5YR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971892
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.952054
neuroblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.586026
BRD-K54386075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59046
linked	GeneRIF Biological Term Annotations	1.0	null
dorsolateral prefrontal cortex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.957954
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02321
Leber congenital amaurosis_Retina_GSE3249	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.55128
Perturb_8186_KD_DNAJC21_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.44255
CASTOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38281
Perturb_14287_KD_TENT4A_SRP237261	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.36646
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00064
MTMR9	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_6463_OE_NFAT1_SRP173011	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.784
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7761
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33413
BRD-K52657580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.046
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05021
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49074
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982178
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0317
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
HNRNPA1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06007
organophosphate biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Perturb_11698_KO_METTL3_SRP287496	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.09248
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215351,GSE215794_1_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7926
Charcot-Marie-Tooth disease type 4B3	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Dimethyl fumarate_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0238705
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K25236390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39915
GTEX-PLZ5-1826-SM-3NB22	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QG-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.10838
ChIP_ZFX_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960983
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
LS-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OXRN-1726-SM-3NM9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Perturb_6404_KO_ERBB_SRP118937	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.72868
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7669-01A-21R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JP-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventricular (matrix) zone of pons	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33281
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TB-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74363294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15809
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.5182
GTEX-N7MS-2625-SM-3LK77	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880949
GM97	BioGPS Cell Line Gene Expression Profiles	1.0	0.886434
BRD-K80782159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30871
Perturb_532_KD_TCF4_SRP234742	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.26742
CRCGN014_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5379
APOBEC3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49497
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.59967
Cholestasis	CTD Gene-Disease Associations	1.0	1.13041
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.53586
ventral posterolateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81103
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04872
myb_16205643_mcf7_gof_human_gpl96_gse2815	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.090821
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
hsa-miR-4434	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-K25016708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23532
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.48649
Perturb_10740_KD_Ddx3_SRP324914	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.46694
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827312
Glasdegib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0348509
Nfe2l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.5978
Perturb_2797_KD_RORC_SRP066204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.15881
Perturb_15995_KD_LUCAT1_SRP221619	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.04155
GTEX-N7MT-0011-R3a-SM-2I3GC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03234
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992822
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4204
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3672	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
BRD-K42061172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00011
GSE168807_0_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36507
BRD-K06486611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07468
PMC6902611-40104_2019_400_MOESM2_ESM.ods-FA-SNA-Total_of_1_054_out_of_1_627_proteins_were_considered_for_analyses_65_SNAI1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90688
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.848123
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.269
PMC10961392__F2	PFOCR Pathway Figure Associations 2024	1.0	null
inferior olive, dorsal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.913605
CRCGN014_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.807
N-Acetylmannosamine	HMDB Metabolites of Enzymes	1.0	null
Perturb_8717_KO_DHRS4AS1_SRP370273	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.80709
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865793
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09394
hsa-miR-623	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K35639494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66823
BRD-K78816149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21565
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.926653
bed nucleus of stria terminalis, lateral amygdaloid division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22969
methoxsalen-6661	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_2763_KD_CBX3_SRP077334	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	13.3574
medial geniculate complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.60171
Perturb_8234_KD_NELFE_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.1316
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2441
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.59179
intracellular part	GO Cellular Component Annotations 2015	1.0	null
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.76613
LXR-22158963-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
primary auditory cortex (core)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03918
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1538
caudal subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33833
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866169
GTEX-OIZH-1826-SM-2YUNP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861039
GTEX-OHPK-2526-SM-3MJH9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.930091
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
CRCGN012_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05067
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.848123
ventral tegmental area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.43903
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC70	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72331
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853816
KATO III	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.44161
OCUM1	CCLE Cell Line Gene CNV Profiles	1.0	1.40774
SFTPC_KO_GDS4876_476_mouse_Lung Type II cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
catabolic process	GO Biological Process Annotations 2015	1.0	null
Congenital myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.772
CRCGN008_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9631
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66532
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.879375
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IE-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEIS1-26253404-OPTIC-CUPS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE112860_5_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_6286_OE_MIR574_SRP139041	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.67808
RBM34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14242
Perturb_13172_KD_Birc6_SRP115807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.89052
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06901
BRD-K54637865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13958
Prostate adenocarcinoma_PRAD_TCGA-G9-7525-01A-31R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.55946
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.91711
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC8567280-EMBR-22-e53014-s008.xlsx-PC3_TIP5_bound_promoter-Unnamed_4_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93040255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18807
NMU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07327
U118MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51099
APEX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78371
ERA-27197147-CHIP-SEQ-ENDOMETRIOID-ADENOCARCINOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_10946_KO_Nr1d1_ERP117724	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.00707
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VX-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K28029070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2858
BRD-K96280720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08113
BRD-K87167435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22164
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
Lateral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25853
RNPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3886
BRD-K11571815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17633
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950178
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60267900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07346
GSE103124_2_v_0_bmpr1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8203-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Metabolism of lipids and lipoproteins	Reactome Pathways 2014	1.0	null
BRD-K37919122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12696
BRD-K30013099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12584
GTEX-VUSG-0526-SM-4KL22	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 940.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39262
ZCCHC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9946
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
glycerophospholipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.44345
GTEX-PLZ4-0008-SM-48TE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862722
BRD-K20071915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23123
Lung adenocarcinoma_LUAD_TCGA-55-8507-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NANOG	ENCODE Transcription Factor Targets	1.0	null
ZNF384_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83487481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12568
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75047
SW156	DepMap CRISPR Gene Dependency	1.0	2.47825
NCIH1836	DepMap CRISPR Gene Dependency	1.0	2.25697
GSE114284_2_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K37696710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84483
Almonertinib (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0204452
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE124410_3_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NPRL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16519
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
D-Fructose	HMDB Metabolites of Enzymes	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942724
Perturb_2464_KD_SETDB1_SRP344480	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.99253
NCIH716	DepMap CRISPR Gene Dependency	1.0	3.21272
Down Syndrome_Brain_GSE5390	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.96651
BRD-K02329600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1833
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K03923461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35886
PLAGL2_deficiency_GDS3010_139_mouse_embryonic small intestine	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2141	CCLE Cell Line Gene Expression Profiles	1.0	1.43961
DEDD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66932
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.31263
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XB-01A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
BRD-K51707293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15321
CRCGN017_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29623
COLO783	CCLE Cell Line Gene CNV Profiles	1.0	1.95905
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
generalized epilepsy with febrile seizures plus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.15666
Nucleus of the solitary tract, gelatinous part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00381
Tetracycline (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0264413
Prion disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K9ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OC-314	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.31407
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27536
GSE193027_1_v_0_krt19_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Inositol phosphate metabolism	Reactome Pathways 2024	1.0	null
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20825
PLEKHG4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21636
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.88433
carcinine-4809	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pleckstrin homology-like domain	InterPro Predicted Protein Domain Annotations	1.0	null
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.868979
Perturb_12703_KO_LIPA_SRP310406	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.19586
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905352
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism biosynthetic process	GO Biological Process Annotations 2015	1.0	null
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
3-acetylcoumarin-4664	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SR786	CCLE Cell Line Gene Expression Profiles	1.0	2.65507
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.21576
GABPA	ENCODE Transcription Factor Targets	1.0	null
hacat	HPA Cell Line Gene Expression Profiles	-1.0	-1.53888
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
r7 part of the posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.92885
GSE142684_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Thalamus, sensory-motor cortex related	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25374
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TFAP2A-35110662-HEPM-HUMAN-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82021299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20669
Protein-tyrosine phosphatase-like	InterPro Predicted Protein Domain Annotations	1.0	null
CRCGN014_HEPG2_3H:C06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07618
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865044
BRD-K97263385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32021
CRCGN016_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.00781
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PPIP5K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50307
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	57.8143
Pituitary	GTEx Tissue Gene Expression Profiles 2023	1.0	1.34857
Perturb_13922_KO_PPARGC1A_SRP314654	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-10.9516
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01825
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.863857
inner CP in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.841623
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.043769
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1159
GSE254770_3_v_1_sin3b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormality of the eye	GWASdb SNP-Phenotype Associations	1.0	0.075998
PEO4	DepMap CRISPR Gene Dependency	1.0	3.68304
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.08676
Lung adenocarcinoma_LUAD_TCGA-55-8615-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100457_TCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.27172
fluoxetine_mus musculus_gpl1261_gse35761	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE114284_1_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lonafarnib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0167387
BRD-K01152687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28754
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09782
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08425
BRD-K14121002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08197
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SHP77	CCLE Cell Line Gene Expression Profiles	1.0	1.66803
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-WHSE-0011-R11A-SM-3P5YY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09267
Pancreas-pancreatic alpha cell	Tabula Sapiens Gene-Cell Associations	1.0	0.902555
Perturb_14214_KO_App_SRP254653	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.35149
K562	BioGPS Cell Line Gene Expression Profiles	1.0	1.14533
HCC1171	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33866
GTEX-Q2AH-0126-SM-48U2B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
STAT3_OE_GDS3444_576_mouse_Cultured embryonic stem (ES) cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
luteolin-6658	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lower respiratory tract disease	GWASdb SNP-Disease Associations	1.0	0.212294
GSE151689_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K02833343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38315
BRD-K48780709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19613
Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9CZ-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1828
hsa-miR-4755-5p	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
butyl hydroxybenzoate-5245	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE179974_3_v_1_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_4908_OE_SNCA_ERP129142	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Perturb_5402_KD_HOXA4_SRP348097	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.66839
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Lateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18608
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K52094743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75077
arcuate nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.54292
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Entorhinal area, lateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13507
TPX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01048
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6326-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
phosphatidylinositol-3,5-bisphosphate phosphatase activity	GO Molecular Function Annotations 2023	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
CRCGN017_MCF10A.WT.HP_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22095
Entorhinal area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10336
BRD-K62248885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0513
PMC12549544-mmc2.xlsx-AA_D14_VS_D21-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE197564,GSE198513_2_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11061611-cd-23-0857_table_s4_suppst4.xlsx-Epithelial_F1-pEpi11_FU1_shared_B_ASCL1_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57172
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.41861
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.874378
Transplanted Heart Complication_Myocardial tissue_GSE582	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.29459
GTEX-WZTO-3026-SM-3NMA2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20302
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.24385
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00292
Temporal association areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.62199
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K51535480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04208
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.54647
Carbidopa (monohydrate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0388426
organic hydroxy compound catabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833515
ZFX-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
superficial stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67531
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24422491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40647
HCV_8week+IFN-a_None_GSE37715	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.7417
hsa-miR-576-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.017945
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCC26	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-M34385771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23434
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.03118
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.02317
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.880816
BRD-K67036882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53865
creutzfeldt-jakob disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.486425
u26684	HPA Cell Line Gene Expression Profiles	-1.0	-0.830108
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A253	CCLE Cell Line Gene CNV Profiles	1.0	2.56134
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949965
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100478_HIP_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.26404
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965161
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15491
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56041
hsa-miR-4784	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.22495
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	0.823929
IM-95M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49074
GSE153443_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K64424704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29608
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
prion disease	GWASdb SNP-Disease Associations	1.0	0.638262
phospholipid dephosphorylation	GO Biological Process Annotations 2025	1.0	null
Perturb_8135_KD_G3BP1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.34678
SOX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15949
mRNA_ZFX_17448993	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
hsa-miR-3194-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.79247
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CORL279	CCLE Cell Line Gene Expression Profiles	1.0	1.76065
GTEX-N7MT-0011-R2a-SM-2I3GI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962309
Perturb_15667_KD_Srsf7_SRP313287	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.50927
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864032
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
phosphatidylinositol-3-phosphate phosphatase activity	GO Molecular Function Annotations 2025	1.0	null
Ventral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76281
KMS34	CCLE Cell Line Gene CNV Profiles	1.0	1.75299
Creutzfeldt-Jakob disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
adrenal_4c	HPA Tissue Sample Gene Expression Profiles	1.0	0.824379
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45779
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09009
Torkinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0267965
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
MZT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02753
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965957
GSE199541_2_v_5_mbd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155031_5_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.936684
GTEX-QDT8-0011-R1A-SM-32PKS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11196
BRD-K99529078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26437
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.860029
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.877392
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28849
Perturb_11808_KO_Il6ra_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.56358
Pons	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.26996
CRCGN017_MCF10A.WT.HP_24H:C02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06229
GTEX-RN64-1226-SM-2TC6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Brain Lower Grade Glioma_LGG_TCGA-HW-7493-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE239541_11_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:I17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27645
hsa-miR-4286	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Ahr::Arnt	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.625
HPAFII	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32677
SP in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.914726
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
Centronuclear myopathy X-linked	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.911
H2BK120ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940425
Crus II, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.929921
GTEX-O5YT-0926-SM-48TDG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
Ligustrazine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245317
hsa-miR-593	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K27me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.24465
GSE214823,GSE214824_6_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.109
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.67682
posterior triangular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.72478
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11733
Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QK-01B-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K41731186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04347
Centronuclear myopathy 6 with fiber-type disproportion	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.864
bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063151
mantle zone of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25376
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
thyroid_5b	HPA Tissue Sample Gene Expression Profiles	1.0	0.871686
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
inositol phosphate catabolic process	GO Biological Process Annotations 2015	1.0	null
ZNF610	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.6224
BRD-K35943892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69546
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
18537972-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977705
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6909-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0041
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ7-2826-SM-2I3FU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826628
pallidal amygdala	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48463
BRD-K45609222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14613
GSE235066_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K97064059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02865
BRD-K03861440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43021
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A954-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3410_KD_Zbtb10_ERP123680	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-XOTO-0011-R9A-SM-4GICI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04083
callosal sling	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.893042
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.97861
GSE235605,GSE235701_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Primary somatosensory area, barrel field, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01318
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.443
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
stratum pyramidale of rostral CA3	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.920083
MZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.958645
GTEX-OXRO-0326-SM-33HBM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872905
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.49756
Fc-gamma receptor III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.011
salivarygland_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.54089
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.3519
organic substance catabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12211054-spectrum.00100-25-s0002.pdf-13-NPAS3_NPAS3	Rummagene Transcription Factor Associations 2026	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.865997
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC11184788-40164_2024_526_MOESM4_ESM.xls-MSC-EV_proteins-Unnamed_4_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z7-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CJUN-26792858-CHIP-SEQ-BT549-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K72842159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22451
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50679
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056863
Perturb_15101_KD_PDHA1_SRP385600	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.73174
CRAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07378
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FU-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAPK8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10342
posteroventral (inferior) parietal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.924784
Quinidine (15% dihydroquinidine)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0225033
Voriconazole_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00865178
BRD-K86838462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3189
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4223-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Phospholipid metabolism	Reactome Pathways 2014	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2914-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07532
BRD-K33456231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58879
SPRYD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44038
CCNK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46313
H4K20me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary hematopoietic stem cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.26008
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Appendix	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.967621
GSE232631_4_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Dentate gyrus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01686
GR-ST	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39081
Orlistat_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0294
NCIH650	DepMap CRISPR Gene Dependency	1.0	4.54734
NCIH211	CCLE Cell Line Gene CNV Profiles	1.0	1.54796
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-3161	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89787
sox4_16636670_acc3_lof_human_gpl96_gds2193	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.694232
Perturb_2785_KD_ESR1_SRP201903	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.44068
496100551_PCx_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.30258
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861713
CRCGN013_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.53411
CDK5RAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07161
Perturb_2515_KD_TEAD4_SRP181909	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.5949
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.41528
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.13303
Perturb_14378_KD_PAX8_SRP276625	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.76993
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Ventral posteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.7661
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.82752
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882954
bemegride-6668	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3213
MLKL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05211
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SK-NEP-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.45861
PMC11462941-CAS-115-2947-s001.pdf-171-JDP2_JDP2	Rummagene Transcription Factor Associations 2026	1.0	null
HINFP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21853
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882372
PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199606_2_v_7_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K51054234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00901
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LI-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Atazanavir (sulfate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0198836
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.884984
Perturb_15766_KD_Pcbp2_SRP218930	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.02045
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23503
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17384
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R7-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4489_KO_Rnu11/Trp53_SRP309496	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.0591
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OTT1_KO_GDS4315_146_mouse_HSC	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
15902281-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
layer 3 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55517
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040522
MT-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00332
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35852
Perturb_3887_KD_EIF2B5_SRP124930	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.09631
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8519-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
macrocephaly-autism syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.413
BRD-K27137352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77445
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6374
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.63387
BRD-K22087390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33254
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.829583
BRD-K61020385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06888
GSE210885_2_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NH-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
risk	GeneRIF Biological Term Annotations	1.0	null
CRCGN010_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26889
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FO-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41517
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE199606_2_v_7_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Choanomastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.896
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01045
naltrindole-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21747
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K26612358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43734
GTEX-QEG5-1426-SM-447AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856448
Perturb_12314_KO_AGO1_SRP136692	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.2359
SRP72	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41333
GTEX-NFK9-0008-SM-4E3JE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
periventricular stratum of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01318
GTEX-QVJO-0526-SM-447CE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
t59-kidney_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.34739
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
shell of SCH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13447
Acute Myeloid Leukemia_LAML_TCGA-AB-2904-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5076
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.54421
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842985
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_47_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S95S-0008-SM-4AT5M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.888858
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
cerebral artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.557661
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.44095
H3K27ac_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superficial stratum of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76281
TAF7	ENCODE Transcription Factor Targets	1.0	null
Schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.15229
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
Perturb_7833_KD_CPSF6_SRP115462	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.97797
phosphatidylinositol monophosphate phosphatase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K83898323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09327
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.14857
primidone-3065	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MES-SA	GDSC Cell Line Gene Expression Profiles	-1.0	-1.49865
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16498
Crus 2, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04258
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.15454
clonidine-4478	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMRC2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92391
Perturb_8257_KD_RBM27_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.6511
Perturb_83_KD_HOXC4|HOXC6_SRP192852	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.60509
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.9103
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.23287
Lung adenocarcinoma_LUAD_TCGA-55-6969-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043212
phosphatidylinositol dephosphorylation	GO Biological Process Annotations 2025	1.0	null
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	1.0	0.906878
hsa-miR-4689	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
H3K4me1_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88777_0_v_1_cnot7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.2687
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
estradiol-6718	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_13802_KO_Mettl14_SRP286301	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
Agranular insular area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41683
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CAL-148	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00292
GSE186810,GSE186813_2_v_1_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14654
Sinomenine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0260776
Temporal association areas, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10544
BRD-K19527338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.253
Perturb_8209_KD_RPS10_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.4312
HCC1500	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
lorglumide-4658	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Intramuscular adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.876
BRD-K73075421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5392
PMC8554124-DataSheet2.XLSX-34-RFX3_RFX3	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.61597
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906391
BRD-K98418950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08825
PMC12211354-12915_2025_2224_MOESM6_ESM.xlsx-Sheet1-Sheet1_The_source_list_of_zebrafish_Npas4b_targets_from_human_NPAS4_targets_in_CHEA3_database_NPAS4	Rummagene Transcription Factor Associations 2026	1.0	null
metabolic	GAD High Level Gene-Disease Associations	1.0	0.303208
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K88384015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5527
BRD-K25791914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.014
dentate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09316
anterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05778
BRD-K43435656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26476
NCAPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64777
PMC11035615-41420_2024_1944_MOESM1_ESM.pdf-11-NFYA_NFYA	Rummagene Transcription Factor Associations 2026	1.0	null
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16646
BRD-K31977946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12553
TBP	ENCODE Transcription Factor Targets	1.0	null
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Muscular Diseases	CTD Gene-Disease Associations	1.0	1.03419
BRD-K62781263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15509
JUN	ENCODE Transcription Factor Targets	1.0	null
GTEX-X261-3226-SM-3NMC3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86481
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-O5YW-0008-SM-4E3IE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
hsa-miR-889	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39364
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25592
Perturb_2325_KD_SF3A1_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.4754
UBR7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44025
single-organism catabolic process	GO Biological Process Annotations 2015	1.0	null
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.943
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03062
CRCGN017_MCF10A.WT.HP_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1682
PF-06260933_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0265369
CRKL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45273
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0599
GSE149096_4_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BAY1125976_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245439
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12254
hsa-miR-550a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
USP6	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K55864253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04817
paraterminal gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.92549
GTEX-OHPN-0011-R9A-SM-4DXUH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895961
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A267-06A-21R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_2793_KD_PRMT1_SRP214436	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.05964
RAB3A_KO_GDS2483_701_mouse_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
N-Acetyl-D-mannosamine 6-phosphate	HMDB Metabolites of Enzymes	1.0	null
BRD-K05392698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17467
BRD-K04786080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34375
BRD-K29936219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08021
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01508	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.987983
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hycanthone-4630	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12617
hsa-miR-211	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03176
CRCGN012_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.75022
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K48999921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27495
SKLMS1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81764
scrapie	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.682693
Crus 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00908
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN012_HEPG2_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02037
ALG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01621
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K53088255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17092
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27511
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4093
SW1417	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33151
azathioprine-4667	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
neuroblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.475812
CRCGN015_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0088
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.891668
Darinaparsin_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.016007
GTEX-NPJ8-0011-R11A-SM-2YUMS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23829
BANP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2063
GATA2_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SJSA1	CCLE Cell Line Gene CNV Profiles	1.0	1.35762
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9369
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974366
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.5534
non-Hodgkin lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12985
r11 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20565
hsa-miR-3074-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
hsa-miR-299-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K08458391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94732
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94155
EP300	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TUT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11903
Anterior cingulate area, ventral part, 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05428
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30216
BRD-K15350548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14762
PMC8567280-EMBR-22-e53014-s008.xlsx-PC3_TIP5_bound_promoter-BAZ2A-regulated_genes_with_BAZ2A-bound_promoter_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.982061
Erectile dysfunction_Penis Erectile Tissue_GSE2457	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.35628
golgi apparatus	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K05857732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11936
CSGALNACT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13323
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08874
GTEX-S7SF-1426-SM-4AT5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879858
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4763-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_5094_KO_Cbx1_SRP104194	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.36902
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.973223
Ectorhinal area/Layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30216
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23747
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17576
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18498
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.2808
Acute megakaryoblastic leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.731
KDM5B	ChEA Transcription Factor Targets	1.0	null
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41234
GTEX-Q2AG-0011-R2A-SM-2HMIT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66126
Perturb_1761_OE_Notch1_SRP311399	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.94444
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906391
PMC7673140-41467_2020_19575_MOESM4_ESM.xlsx-Data_S1d-List_of_2302_of_genes_differentially_regulated_by_SOX2_FDR_0_1_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_3299_KO_Bmpr1a_SRP116199	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.2643
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F2-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE90019,GSE90020_5_v_2_phf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05297
NOS1	DepMap CRISPR Gene Dependency	1.0	2.03137
GSE174383_4_v_5_ly6d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-5396-01A-02R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XGQ4-1826-SM-4AT6F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN009_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.90301
CTCF	ENCODE Transcription Factor Targets	1.0	null
BRD-K60937893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74368
BI-78D3_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00887492
cellular process	GO Biological Process Annotations 2015	1.0	null
phosphatidylinositol metabolic process	GO Biological Process Annotations 2015	1.0	null
CARD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30874
CRCGN017_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28224
muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Perturb_17641_OE_YAP_SRP298391	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	7.16159
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09961
CHD7	ENCODE Transcription Factor Targets	1.0	null
obesity	GWASdb SNP-Disease Associations	1.0	0.819144
GSE149903_4_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922321
CRCGN014_HEPG2_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43115
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.75804
periventricular stratum of m2AD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54203
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
adrenal_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.02395
GSE254517_2_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_Fetal Heart	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE114284_4_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173810_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cholesterol, LDL	dbGAP Gene-Trait Associations	1.0	0.105922
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K34445094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74252
SK-MES-1	GDSC Cell Line Gene Expression Profiles	1.0	2.66237
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_4538_KO_Mtf2_SRP103933	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.17825
Perturb_9248_KO_Setdb1_SRP332486	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	9.12311
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE214382,GSE214383_4_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Entorhinal area, medial part, ventral zone, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.81476
CRCGN012_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4429
r5 part of the cochlear column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.00656
EIF3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1177
Prostate adenocarcinoma_PRAD_TCGA-FC-7708-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE214382,GSE214383_6_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_11879_KO_Suz12_SRP322808	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.89628
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.887635
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
JHU011	DepMap CRISPR Gene Dependency	1.0	2.14619
PMC12678582-41698_2025_1153_MOESM5_ESM.xlsx-Sheet1-Common_genes_between_OVCA420-ZNF217_and_MCF7_157_965_1122_ZNF217	Rummagene Transcription Factor Associations 2026	1.0	null
heart_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.879527
ramipril-6792	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.915941
hsa-miR-520h	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
NCIH1836	CCLE Cell Line Gene Expression Profiles	1.0	2.13763
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OXRP-0926-SM-48TC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863891
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
Metabolism	Reactome Pathways 2014	1.0	null
SARS-CoV_24Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.8999
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11821
Prenatal Injuries	CTD Gene-Disease Associations	1.0	1.04647
phospholipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-3909	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K90806964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27685
SOWAHD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77182
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Rosiglitazone_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0191818
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.907525
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sclc21h	HPA Cell Line Gene Expression Profiles	1.0	2.63745
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149903_5_v_2_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K22875065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07465
JHOS4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.61671
r5 part of posteroventral cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.95997
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.27697
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A66X-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2925
hsa-miR-4799-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02524
phosphatidylinositol-3-phosphate phosphatase activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
MAX	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q2AH-0826-SM-48TZN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03057
BRD-K80381603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68292
BL2030 (RFWD2)	NURSA Protein Complexes	1.0	null
GTEX-RN64-1026-SM-48FDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17519
GTEX-R53T-0826-SM-48FCP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GSE160765_2_v_1_twist1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.572
SW1116	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32174
Brain stem	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.14
BRD-K79735667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80815
nucleus sagulum, deep part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18608
Learning Disorders	CTD Gene-Disease Associations	1.0	1.72055
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V955-2026-SM-3GAFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-P44H-0011-R5A-SM-2XCEX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07856
norfloxacin-7283	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ebolavirus(EBOV)_5day_Splenocytes_19683682_GSE17509	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.60271
BRD-K24743998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04577
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44177
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3396
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZF-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE186810,GSE186813_7_v_1_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.315729
BRD-K95218317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00042
PMC12821819-40478_2025_2173_MOESM9_ESM.xlsx-Supplementary_Table_3a-Supplementary_Table_3A_List_of_Top_1000_Genes_with_the_Highest_Stochasticity_by_JSD_in_the_ATRT-MYC_Subtype_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
DBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28216
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83267
CP in rostral hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.988899
BJHTERT	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50329
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.894491
Adrenocortical carcinoma_ACC_TCGA-OR-A5L9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
glycerophospholipid biosynthetic process	GO Biological Process Annotations 2025	1.0	null
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Posterolateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03171
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE88819_7_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RCC4	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81922
Perturb_10035_KD_PUM1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.95141
RCC-ER	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-3187-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
phospholipid metabolic process	GO Biological Process Annotations 2015	1.0	null
496100323_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03057
hsa-miR-1298	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11712
GATA2_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K83238251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68548
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-1326-SM-4LVN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.68091
amygdala	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_8758_KO_SETDB1_SRP141213	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.53694
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23601
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.171034
CAKI-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01863
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SNOS-1226-SM-4DM5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Perturb_2324_KD_SF3A1_SRP268983	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.3274
superficial stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77017
CRCGN009_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16304
superficial stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00784
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6294
GSE226316_6_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sapanisertib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00978651
FARAGE	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K15609977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10363
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
n1e-115 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.24208
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28982281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00676
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	2.80851
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15759_KO_Msi1_SRP353788	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.32553
Urinary Bladder Neoplasms	CTD Gene-Disease Associations	1.0	1.03308
hsa-miR-502-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02697
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
amygdalo-striatal transition	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06815
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Perturb_10001_KD_FMR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.11709
Basal ectoplasmic specialization	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.509
GSE118617,GSE118619_2_v_3_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3927	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BRD-K99412981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18314
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8252
myosmine-4293	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32241
TAF1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63838
Perturb_1327_KD_COX2_SRP074235	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.98505
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3	JASPAR Predicted Transcription Factor Targets	1.0	null
Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.826341
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906391
mediodorsal nucleus of thalamus_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.96727
ATP6V1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60963
GTEX-X4XX-0011-R2A-SM-3P623	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0962
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28089
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K34335352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01193
Limbic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PFKM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14395
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08633
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
AOB, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4196
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052064
Creutzfeldt-Jakob disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.395
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25893
BRD-K68605096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70425
MHHNB11	CCLE Cell Line Gene Expression Profiles	1.0	1.35514
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1726_KO_Zeb1_SRP269619	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.4561
ATM_KD_GSE54268_663_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Neoplasms	CTD Gene-Disease Associations	1.0	1.05386
BRD-K35407043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06787
hsa-miR-204	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4904_KO_NSUN6_SRP233222	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_1154_KO_USP29_SRP329795	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.20567
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37689
Lung adenocarcinoma_LUAD_TCGA-78-7153-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4264	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6954
GATA2	ENCODE Transcription Factor Targets	1.0	null
BRD-K25127909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42138
protein dephosphorylation	GO Biological Process Annotations 2015	1.0	null
Perturb_8914_KO_KDM1A_SRP348808	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.26036
GNPDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29027
Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PYGM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09353
ESRRB	ChEA Transcription Factor Targets	1.0	null
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ITK_defectivemutant_125_GSE28200	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.50156
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899116
GSE234289_5_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1693	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TE-11	GDSC Cell Line Gene Expression Profiles	1.0	2.02024
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Fluvoxamine_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0109351
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.6854
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RHBDL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46258
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
BRD-K61052964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03245
NRF1	ENCODE Transcription Factor Targets	1.0	null
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.909666
Perturb_4236_KD_Cnot7_SRP091584	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.4277
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Ralimetinib dimesylate_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0194976
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4857-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48305
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3577
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE199255,GSE199356_3_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.968403
organic hydroxy compound metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
GSE200673,GSE200691_2_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.015
p2 part of the zona limitans core population	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05877
DEL	CCLE Cell Line Gene Expression Profiles	1.0	2.04754
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21682
CHK2_KD_GSE54268_668_human_MCF-10A	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986264
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC8561673-NIHMS1742950-supplement-Table_S7.xlsx-Housekeeping_MYC_ProxTubGenes-Proximal_Tubule_Enriched_Genes_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	132.543
Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX17-20123909-XEN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.908253
CRCGN014_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57344
GSE142232,GSE142234_0_v_2_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119603_1_v_0_oxaliplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE95685_4_v_5_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.81915
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
16207381-Table1Sb	GeneSigDB Published Gene Signatures	1.0	null
dorsalrootganglion	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.59582
dorsal part of m2A	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54272
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE101239_5_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gonadal sheath cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
KAP1-27257070-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8920_KD_P300_SRP256204	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.22038
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6809
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.05333
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23422
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924465
REST_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07279
SETDB1-19884257-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6827-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SR-786	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.03875
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7866-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS934T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83091
CRCGN017_MCF10A.WT.HP_24H:K16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2186
Perturb_6684_KD_SMARCA2_SRP378606	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76609014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02066
flupentixol-6708	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ChIP_RCOR3_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC9533694-MOL2-16-3410-s013.xlsx-FIR20vsREST_DEMs-FIR20_vs_REST_DEMs_Down_REST	Rummagene Transcription Factor Associations 2026	1.0	null
phosphate-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
NEU3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25227
VDR-24787735-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051325
GI-ME-N	GDSC Cell Line Gene Expression Profiles	-1.0	-1.87728
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.0
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4620-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
parvocellular part of r8LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07785
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83385
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10475
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05366
Eye-eye photoreceptor cell	Tabula Sapiens Gene-Cell Associations	1.0	10.9469
Posterolateral visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29733
r9 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09313
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Perturb_9249_KO_Setdb1_SRP332486	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	14.5193
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.276
palbociclib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0188087
PDX1_KO_GDS4348_360_mouse_Proximal small intestine	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.33419
Perturb_8285_KD_DDX27_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.30162
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22505
hsa-miR-1179	TargetScan Predicted Conserved microRNA Targets	1.0	0.127531
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1399
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.398
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.23912
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03207
KDM5B-21448134-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
A549	GDSC Cell Line Gene Expression Profiles	-1.0	-2.39183
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887432
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RJ-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.68846
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.41199
Perturb_8841_KO_PSMA3_SRP281428	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.36203
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37387086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14564
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_8134_KD_FXR1_SRP013565	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-9.16301
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15390_KD_E2F1_SRP399677	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.51629
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-A61522392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11036
Perturb_17316_KO_Tardbp_SRP321767	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.6461
ZBTB7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.381
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97383
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30973
TCF21-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.49395
orbital frontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00429
BRD-K11741103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49522
BRD-K07482874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52686
GSE165174,GSE165175_0_v_1_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K83645749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12062
BRD-K93295557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37844
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.74849
BRD-A58937872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09231
GSE118617,GSE118619_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K52764062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19662
Temporal lobe	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me1_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K27997230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06167
BRD-K77519898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36792
hsa-miR-4775	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
8p23 1 copy number variation syndrome	WikiPathways Pathways 2024	1.0	null
H3K27me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61796
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEG5-0326-SM-2S1PB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52471
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171352_2_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.943683
BRD-K07160568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57846
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32183
GSE179974_3_v_4_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
phosphoprotein phosphatase activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K08715020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65887
BRD-K69241192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14268
Creutzfeldt-Jakob Syndrome	HuGE Navigator Gene-Phenotype Associations	1.0	null
mantle zone of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25156
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
hsa-miR-590-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37809
inner CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14664
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101239_4_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NUDT17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23306
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.027681
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43072
Ventral posterolateral nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83293
Perturb_8681_KD_ZNF827_SRP318474	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.59165
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZFX	ChEA Transcription Factor Targets	1.0	null
BRD-K08431704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51525
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19127
Myotubularin-like phosphatase domain	InterPro Predicted Protein Domain Annotations	1.0	null
layer 2 of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59579
MZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.922516
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	0.944302
CRCGN015_MCF10A.TP53.M_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08952
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	1.21853
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.992449
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.827907
H3K27me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_43_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0439
GTEX-NPJ7-0011-R2a-SM-2I3GF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954916
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7390_KO|KD_UPF3A_ERP130415	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.18395
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.14597
GSE148692,GSE148695_2_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Acute megakaryoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1097
mantle zone of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47972
Perturb_16845_KO_Kcnj10_SRP241402	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.6155
BRD-K69074358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13581
BRD-K74855272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26938
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_mouse_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28467592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0088
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060893
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.04524
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.036302
oxedrine-6798	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_2990_KO_UTX_SRP108473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.113
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997845
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.978314
Brain Lower Grade Glioma_LGG_TCGA-DU-7302-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860098
SU-DHL-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.955548
variant	GeneRIF Biological Term Annotations	1.0	null
GSE88819_0_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35578
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05275
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7539
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.16068
genomewide	GeneRIF Biological Term Annotations	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Kuru	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_54_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN010_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6519
carbohydrate metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC11214527-mmc5.xlsx-TCF4-gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NPJ7-0011-R9a-SM-2TC5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04295
V	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.827315
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BICR78	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
ESRRB-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69520171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13244
BRD-K88836117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45332
phosphatidylinositol bisphosphate phosphatase activity	GO Molecular Function Annotations 2025	1.0	null
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
H3K27ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE149903_5_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
brain_3b	HPA Tissue Sample Gene Expression Profiles	1.0	1.65629
GTEX-U3ZN-2026-SM-4DXUC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
NCIH69	CCLE Cell Line Gene Expression Profiles	1.0	1.84948
TRIM28-17542650-NTERA2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
peptidyl-tyrosine dephosphorylation	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5986-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
periventricular stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40353
abnormality of the lung	GWASdb SNP-Phenotype Associations	1.0	0.546287
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4113
GTEX-X4XX-0011-R11A-SM-46MWQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43157
GSE148262,GSE150691_1_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MM-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.25615
UMC-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4621
MDA MB435	BioGPS Cell Line Gene Expression Profiles	1.0	1.5429
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A8O6-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.037655
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Perturb_439_KD_MEP50_SRP073189	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.40897
prilocaine-4749	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_15163_KD_PGR_SRP097736	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.50747
Perturb_17490_KO_Krt13_SRP248501	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.51274
Perturb_17036_KD_RUNX2_SRP265978	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.91066
hsa-miR-450b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Perturb_12702_OE_ERG/FLI1_SRP397680	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.81694
superficial dorsofrontal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27974
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.959916
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16655
H3K9ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
salivary gland	HPA Tissue Gene Expression Profiles	-1.0	-1.54151
GSE254770_0_v_1_sin3b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.381
Dok	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.752
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE183101_0_v_1_hvcn1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nicolaides-Baraitser syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.293
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3471-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6470-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_61_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.903207
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4703
JAR	COSMIC Cell Line Gene Mutation Profiles	1.0	null
basal ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE173810_4_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
polyol metabolic process	GO Biological Process Annotations 2015	1.0	null
Cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_6711_KD_STAU1_SRP266909	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.06591
GSE186810,GSE186813_2_v_1_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843578
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26192
CRCGN012_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07861
Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32930844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02676
BRD-K56470219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.46532
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Entorhinal area, medial part, ventral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4873
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
troglitazone-6191	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6811-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE120370_4_v_1_thrombin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
UBE3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12126
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
RAB3A_Mutation - D77G point mutation_GDS2483_698_mouse_Hippocampus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A97Q-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14736
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48217
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08141
Perturb_12522_KD_MUC1_SRP381930	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.02752
Perturb_10637_KO_Sip1_SRP028877	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
BRD-K50146114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41974
chr8_17413328_G_C_b38	GTEx eQTL 2025	1.0	2.02585
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30271
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195503_3_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRAF_drug inhibition_GSE42872_368_human_A375	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A59V-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXL2NB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94614
GTEX-V1D1-1026-SM-4JBHE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902403
shsy5y	HPA Cell Line Gene Expression Profiles	1.0	1.52734
phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IO-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARHGAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42394
Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_11384_KD_CIT_SRP173646	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.56435
Perturb_11226_KD_Mafg_SRP165897	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.02141
BRD-K25942808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96445
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883832
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EA-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1428	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49134
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-2426-SM-2XCEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81547
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.982004
hsa-miR-4797-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BRD-K53186055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18251
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IH-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.6883
Prostate adenocarcinoma_PRAD_TCGA-H9-A6BX-01A-31R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IALM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62616
ZKSCAN3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.2762
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DX-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH209	CCLE Cell Line Gene Expression Profiles	1.0	1.79252
HNF4A	ChEA Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A5W9-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU245	CCLE Cell Line Gene Expression Profiles	-1.0	-1.90502
Posterolateral visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.81666
hsa-miR-4263	TargetScan Predicted Conserved microRNA Targets	1.0	0.011888
MOLM13	CCLE Cell Line Gene CNV Profiles	1.0	1.5974
GSE131649_2_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAPKAPK2	Kinase Library Serine Threonine Kinome Atlas	1.0	null
KHM1B	CCLE Cell Line Gene CNV Profiles	-1.0	-1.75273
BRD-K84710243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05786
DHRS7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62555
17683608-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Congenital structural myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.989
CREB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05245
GTEX-V1D1-0226-SM-4JBHG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862562
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4791
GSE246053_4_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RTLS-0826-SM-2TF5Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848318
increased mean corpuscular hemoglobin concentration	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-WZTO-2826-SM-3NM8P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2948
hsa-miR-4328	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
BRD-K73227372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15742
CST6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47758
GTEX-XUYS-0008-SM-47JYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88672
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38845
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K04559718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66026
hsa-miR-548ah	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.78036
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0364
Growth Disorders	CTD Gene-Disease Associations	1.0	1.11501
intermediate stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18608
Omegasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.532
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-3126-SM-3P5ZI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959506
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.944451
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8582
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11483
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19092
FOSL1	ENCODE Transcription Factor Targets	1.0	null