association dataset threshold value standardized value anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10017 H3K27me3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PPM1G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89321 PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39102 protein metabolic process GO Biological Process Annotations 2015 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE236228_0_v_1_penfluridol_human RummaGEO Drug Perturbation Signatures 1.0 null Mucosa TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.913185 PD-70-VS77_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.30008 ARHGEF25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19592 hippocampus (hippocampal formation)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.35668 GSE111247_14_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-WT-gene_symbol_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null METTL2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3098 DNAJC28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59578 soft tissue HPA Tissue Protein Expression Profiles -1.0 -1.47733 HCC1833 CCLE Cell Line Gene Expression Profiles 1.0 1.49408 EBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.6465 ADAL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93869 STK24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53897 BC-54-ON71_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.324365 Lymphoid cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.011 JHUEM7 DepMap CRISPR Gene Dependency 1.0 2.40365 GSE219195_0_v_2_rbm12_human RummaGEO Gene Perturbation Signatures 1.0 null SUDS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31329 SMIM30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71257 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3121-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 SIN3A ENCODE Transcription Factor Targets 1.0 null ALKBH5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75387 NUP153 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7736 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45229 CKS1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45137 BRSK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35871 Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CHLA266 DepMap CRISPR Gene Dependency 1.0 2.14091 Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34757 496100315_TCx_no dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.30584 hsa-miR-1286 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 RFK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92001 ZNF639 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01076 IRF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82794 OGT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74179 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.874613 DDX19A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81524 RCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06661 SULT2A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21942 Oral mucosa TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BRAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38033 SLC30A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04316 TRAFD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57853 ZNF485 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86183 THUMPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46398 macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null ZNF440 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33234 CSRP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32036 hsa-miR-4731-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 PMC12126244-jci-135-184115-s239.xlsx-Table_3_Suppl_Fig_16-Genes_down-regulated_in_SOX9_low_tumors_744_genes_SOX9 Rummagene Transcription Factor Associations 2026 1.0 null internal segment of globus pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.889111 ERG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.23452 GRWD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41109 CBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42119 SLFN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22435 SNU398 DepMap CRISPR Gene Dependency 1.0 9.3755 N4BP2L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89074 Brain Lower Grade Glioma_LGG_TCGA-S9-A7QW-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MTAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39876 HT144 DepMap CRISPR Gene Dependency 1.0 2.24513 primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.829332 primary motor cortex (area M1, area 4)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.842187 layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.825094 TTLL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03314 Brain Lower Grade Glioma_LGG_TCGA-HW-A5KJ-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nucleus of diagonal band Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.04959 HDAC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68745 TTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41177 posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03417 OV7 CCLE Cell Line Gene Expression Profiles -1.0 -1.45833 HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24004 ZNF320 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 299.046 ATRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02826 SLC7A8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85958 GSE157684,GSE173391_0_v_1_rgcc_human RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MS-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7009 ZKSCAN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55312 FF-06-MO73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.325385 Lung adenocarcinoma_LUAD_TCGA-55-8090-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null pancreas GTEx Tissue Gene Expression Profiles 1.0 0.825439 STARD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63437 496100343_TCx_possible Alzheimer's disease_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.76024 ESCO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61561 Blood TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.011 POLR3G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7035 GSE214212_2_v_0_chd6_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-4298 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 LEMD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42314 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A1NK-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.38214 Perturb_5600_KD_ESCCAL1_SRP259187 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 TUBE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6376 IFIH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31526 Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-A4AQ-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FUCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75458 HS294T CCLE Cell Line Gene Expression Profiles -1.0 -2.20912 GSE219274,GSE219276_2_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null KLF10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 281.306 EEF1E1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30046 HCN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.63789 FAM236B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47945 ZNF722 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77897 primary auditory cortex (core)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.830975 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.25562 cervix uteri GTEx Tissue Gene Expression Profiles -1.0 -1.01175 PRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64005 HS 683 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29969 HMGN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.08779 KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2131 primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02122 ABHD14B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49069 MDAMB436 CCLE Cell Line Gene CNV Profiles 1.0 1.49188 ZNF248 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61044 hsa-miR-3184 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 KNSTRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87021 HSDL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34264 dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01257 SLVL DepMap CRISPR Gene Dependency 1.0 2.18272 glutamyl-tRNA(Gln) amidotransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.175 IZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.842549 EC-62-OE64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.375796 acetyltransferase complex GO Cellular Component Annotations 2015 1.0 null ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Corpus striatum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.035 CLN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27907 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD23A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.63294 RAB3IP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03779 SP1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FDX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98708 Dorsal fin TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.734 cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null PRKCG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.54527 TUSC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53095 PSMB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62225 PSMC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61534 UBR7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78125 TM9SF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84777 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELOA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96876 duodenum HPA Tissue Protein Expression Profiles 1.0 1.4499 GCNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01919 ZNF654 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4783 Leukocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.011 Perturb_8980_KD_MEOX2_SRP358321 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.83964 WC-16-IR43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.408215 EIF4EBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84473 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A431-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SH4 DepMap CRISPR Gene Dependency 1.0 3.63166 RAD51B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82938 PIP5K1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.26818 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.965433 RNF26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.21284 primary somatosensory cortex (area S1, areas 3,1,2)_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.826749 primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.27212 ANKMY2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75607 ATF2 ENCODE Transcription Factor Targets 1.0 null IZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22229 hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40219 WDR53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56138 Prostate adenocarcinoma_PRAD_TCGA-TK-A8OK-01A-22R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null doxorubicin_homo sapiens_gpl6947_gse25741 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CXCL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12063 protein acetyltransferase complex GO Cellular Component Annotations 2015 1.0 null HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.927532 Kidney renal clear cell carcinoma_KIRC_TCGA-B2-4098-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rostral division of OFCi (area 11) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05246 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PHH TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.645 Von Willebrand's disease 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.444 cellular protein modification process GO Biological Process Annotations 2015 1.0 null CCDC74B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69408 DKKL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93193 posteroventral (inferior) parietal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.828467 ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.85298 H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PTGFRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24381 ERCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44698 transferase activity, transferring acyl groups other than amino-acyl groups GO Molecular Function Annotations 2015 1.0 null IZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.16196 DHX37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56519 bladder GTEx Tissue Gene Expression Profiles -1.0 -2.08156 dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.47056 OACP4C COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 MAX ENCODE Transcription Factor Targets 1.0 null SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03787 NOTCH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61052 peptide alpha-n-acetyltransferase activity GO Molecular Function Annotations 2015 1.0 null MCMBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51172 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VTI1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94082 rectum HPA Tissue Protein Expression Profiles 1.0 1.4499 EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.0876 primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.98154 RAB4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60698 TNFRSF13C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39368 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CDCA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87035 PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null ZNF32 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.63099 SP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 264.379 TFAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32401 NAV2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76978 C18orf21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0916 ASCL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49338 MFSD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91428 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.07714 SNU840 CCLE Cell Line Gene Expression Profiles -1.0 -1.72624 MDAMB453 CCLE Cell Line Gene CNV Profiles -1.0 -2.15879 MAZ ENCODE Transcription Factor Targets 1.0 null ventrolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10456 NEUROD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.972 RSBN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68709 NFATC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19475 SNU1214 CCLE Cell Line Gene Expression Profiles -1.0 -2.31972 posteroventral (inferior) parietal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14535 inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21809 IRF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.2011 orbital frontal cortex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16107 SLC35F6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.10008 PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S18-Table_S18_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-002_4H_vs_DMSO_RUNX2 Rummagene Transcription Factor Associations 2026 1.0 null PMAIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90098 UBL7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5852 dorsal subdivision of VLC Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.43313 NCIH2141 CCLE Cell Line Gene Expression Profiles -1.0 -2.36384 PDZD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8817 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LYSP100-associated nuclear domain COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.319 RBM18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60138 KNTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27656 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null OE33 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45229 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WW-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAFK JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.9043 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4735-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9568 BPGM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.62144 ARL2BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67186 macromolecular complex GO Cellular Component Annotations 2015 1.0 null LAPTM4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31687 PD-70-VS77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.509695 GPRIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70503 Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5SQ-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null principal sensory nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.22988 hsa-miR-4436b-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 primary auditory cortex (core)_25 pcw_F_12948 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.980908 H3K27me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPSB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54063 SOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93629 BL4711 (PDCD4) NURSA Protein Complexes 1.0 null H3K4me1_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Nerve TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.006 ALDH9A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57535 SFRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.42675 GSE149366_1_v_0_sulconazole_human RummaGEO Drug Perturbation Signatures 1.0 null RASSF8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04097 MRPS14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06378 DMXL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13918 CHD1 ENCODE Transcription Factor Targets 1.0 null MAP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.8956 H3K27me3_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.23289 p95 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.708 orbital frontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.12701 hsa-miR-491-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 ZNF226 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35431 FAM171A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69833 H3K4me1_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100481_PCx_no dementia_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.25709 KDM5D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33294 KAT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90626 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.957932 CHMP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37451 ZKSCAN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54049 LHFPL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10727 NHBE cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.593 HEY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.961388 n-acetyltransferase activity GO Molecular Function Annotations 2015 1.0 null pituitary GTEx Tissue Gene Expression Profiles 1.0 2.08896 H3K36me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ventrolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.24258 HOXD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39323 shsy5y HPA Cell Line Gene Expression Profiles 1.0 0.879717 hsa-miR-762 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 DUT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52515 posteroventral (inferior) parietal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.872163 nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null MDA-MB-453 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13654 EBF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.2183 MAP4K5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3428 striatum_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06604 HT1080 CCLE Cell Line Gene Expression Profiles -1.0 -1.52342 posterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.57055 PTGIS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3036 transferase activity, transferring acyl groups GO Molecular Function Annotations 2015 1.0 null GSE205163,GSE205164_5_v_6_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3346-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39026 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 NDEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.84851 MMP16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82138 PNP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8152 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.893732 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858043 CTNNB1 ChEA Transcription Factor Targets 1.0 null GSE214725_1_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null WC-16-IR43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.25538 ACSBG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79752 HGS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71978 SEC31A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16361 posteroventral (inferior) parietal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.96915 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HOXC11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0889 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832799 PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1 Rummagene Transcription Factor Associations 2026 1.0 null TUB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.55289 oculomotor nuclear complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.54039 hsa-miR-4270 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GSE156454_0_v_1_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null CLDN34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16156 NCIH209 CCLE Cell Line Gene Expression Profiles -1.0 -1.4581 Rectum adenocarcinoma_READ_TCGA-EI-6883-01A-31R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11544636-CCS3-18-e12047-s001.xlsx-Supplementary_Table_S2-Supplementary_Table_S2_554_differentially_expressed_genes_between_DOX_and_CTR_D0_in_A673pTERshEWS_FLI1_model_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null TSHZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42932 RIMS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30722 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.75723 INSM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 50.3333 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08991 MTA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.81502 VEZT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39474 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COA8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34234 dorsolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20113 ERLIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42523 hsa-miR-4706 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TP-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE169152_3_v_1_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null NEUROG2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.2722 paracentral lobule, posterior part, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19965 SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null D423MG DepMap CRISPR Gene Dependency 1.0 2.50658 KLHL12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86324 Perturb_7957_KD_ZCCHC8_SRP222099 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.51787 GAP43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81913 red nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.963463 NPY1R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.05518 TULP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00643 HEY2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7577 ELF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8589 EFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95468 hsa-miR-505 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 PD-70-VS77_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.234873 KIAA1191 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27531 CAPZB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50344 Superoxide dismutase copper chaperone complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.193 RAB9A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69167 F3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.14268 GSE162892_3_v_0_isox_human RummaGEO Drug Perturbation Signatures 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.24608 H3K27me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ophthalmic nerve TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.006 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03984 hsa-miR-4755-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 MYCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25429 amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.82092 EBC1 DepMap CRISPR Gene Dependency 1.0 4.15269 BT16 DepMap CRISPR Gene Dependency 1.0 5.5049 primary motor cortex (area M1, area 4)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1167 BA-59-EN38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.210518 peptidyl-amino acid modification GO Biological Process Annotations 2015 1.0 null VLDLR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44011 hsa-miR-1237 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21391 PHF21A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75593 CACNB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86941 LU99 CCLE Cell Line Gene CNV Profiles -1.0 -2.86649 PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC Rummagene Transcription Factor Associations 2026 1.0 null E2F6_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PA-TU-8902 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858043 SEZ6L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33399 area postrema Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.969236 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_mononuclear cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06171 GSE228261_0_v_1_elesclomol_human RummaGEO Drug Perturbation Signatures 1.0 null MAPRE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46468 CYREN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89022 hsa-miR-31 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE202825_2_v_1_ano1_human RummaGEO Gene Perturbation Signatures -1.0 null NCOA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46834 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.97821 PSMD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77599 ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.899769 ventrolateral prefrontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.29702 NCS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.242 Prostate adenocarcinoma_PRAD_TCGA-HC-7821-01A-12R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DPYSL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.85741 Brain Lower Grade Glioma_LGG_TCGA-QH-A6X8-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AP1AR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92057 PLD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80943 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04409 HMGB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.943 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.51856 H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.833581 Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDR2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.43382 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08593 HSD17B4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56283 PAX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16391 PDRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49391 URI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30364 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null NUDT19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20843 Parietal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.0 TDRKH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97979 IZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.983059 H3K27me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null central gray substance of midbrain, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.932394 SAP30 ENCODE Transcription Factor Targets 1.0 null NB4 DepMap CRISPR Gene Dependency 1.0 2.90256 Prostate adenocarcinoma_PRAD_TCGA-V1-A8MU-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100323_FWM_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.20094 NCIH1385 CCLE Cell Line Gene Expression Profiles 1.0 2.35707 CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19005 CEP41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.75812 RECQL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44912 RKO CCLE Cell Line Gene Expression Profiles 1.0 1.48589 hsa-miR-4534 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 PMC9882185-media-4.xlsx-Neuron_KD-ID_AR Rummagene Transcription Factor Associations 2026 1.0 null CCDC142 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54606 peptide n-acetyltransferase activity GO Molecular Function Annotations 2015 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null catalytic activity GO Molecular Function Annotations 2015 1.0 null interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2539 ZNF484 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.49019 peptidyl-methionine modification GO Biological Process Annotations 2015 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6868-01B-12R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BB-42-FF52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.233481 EOLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09615 H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-69-A59K-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE193258,GSE193259_2_v_4_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.42709 CORL51 CCLE Cell Line Gene Expression Profiles 1.0 1.78726 ES-WA7 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.14235 IX Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.03014 H3K27me3_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ABHD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90799 MMP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.56132 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null Melanophore TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.654 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RBMS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10183 FF-86-NH56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.267153 FAM193A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1702 acetyltransferase activity GO Molecular Function Annotations 2015 1.0 null hsa-miR-4498 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 EPLC272H DepMap CRISPR Gene Dependency 1.0 3.01964 TLX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4253 SG in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06808 HES5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.8347 YOD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87353 496100328_TCx_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.50747 H3K27me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NOTCH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18147 WDR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19139 AE-39-DG66_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.254142 SPAG8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38639 FARSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34618 FOXF2 JASPAR Predicted Transcription Factor Targets 1.0 null MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAM8A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.87953 THAP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69237 OE21 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 B3GAT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.16782 CBFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01655 JL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17427 NEUROD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87815 KLHDC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33418 Rectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06727 GSE236280_0_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null PRMT8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.04765 GSE236003_2_v_3_ubr5_human RummaGEO Gene Perturbation Signatures 1.0 null CLPTM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39108 small intestine HPA Tissue Protein Expression Profiles 1.0 1.4499 TEAD4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RRS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26082 ANO9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39303 PPP1R16A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65504 n-acyltransferase activity GO Molecular Function Annotations 2015 1.0 null GNL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51225 Trigeminal nerve TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.006 LIG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82264 HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UQCR11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6181 H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TMEM86B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51985 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77752 SW1353 CCLE Cell Line Gene Expression Profiles 1.0 2.02494 ZNF260 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67873 HES7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.9061 Brain Lower Grade Glioma_LGG_TCGA-VW-A7QS-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VI, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32679 IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.894307 TBL1Y CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53468 SP1 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A65F-01A-21R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.4706 EBF1 ENCODE Transcription Factor Targets 1.0 null BCAN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04989 HCCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1364 ELMO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99015 YA-78-MS95_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.318488 POU6F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64516 PRSS27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07224 ELF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92723 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 496100366_TCx_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.10966 ZNF391 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.29373 CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.92003 SC-67022 (SPDEF) NURSA Protein Complexes 1.0 null hippocampus (hippocampal formation)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.08587 ALAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00206 SHROOM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14531 RTBDN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41829 ZFAND2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.36448 MSH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49656 DNER CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74973 GSE233679_5_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null ECH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24605 H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NKX1-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09525 SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29073 EE-03-SG02_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.39103 Acyl-CoA N-acyltransferase InterPro Predicted Protein Domain Annotations 1.0 null PANC0504 DepMap CRISPR Gene Dependency 1.0 3.12536 NCAPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38134 Lung adenocarcinoma_LUAD_TCGA-MN-A4N5-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DDT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.03755 SKMEL5 CCLE Cell Line Gene Expression Profiles 1.0 1.88979 Pancreatic adenocarcinoma_PAAD_TCGA-H6-A45N-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAPK9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63748 CAL-12T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.880428 Von Willebrand's disease 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.389 CEP104 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13199 PYCARD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.73455 GSE144500_8_v_2_ventx_human RummaGEO Gene Perturbation Signatures 1.0 null SP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 297.204 HOXB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02798 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14257 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4837-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EC-62-OE64_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.439216 Brain Lower Grade Glioma_LGG_TCGA-TM-A84H-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ABCG4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51013 ZNF155 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17272 GCM2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6453 MAN2C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49433 parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.85739 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC39A10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42142 RSAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56885 KMRC20 CCLE Cell Line Gene CNV Profiles 1.0 1.4966 HES1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8374 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TMEM43 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.28682 RPS6KB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62361 medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.5565 Perturb_7958_KD_ZCCHC8/ZFC3H1_SRP222099 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.4396 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.880428 hsa-miR-4469 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 DNMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85424 GSE146982_7_v_5_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null HCC2279 CCLE Cell Line Gene CNV Profiles -1.0 -1.85952 CACNG6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60152 RXRA::VDR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0 ACO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.00126 KLF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 189.981 COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null ZNRD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5505 dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.955638 RAB40C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93859 FKBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.61221 NAA15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37955 MITF-21258399-MELANOMA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null SYNM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51342 TTC14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.6364 COPS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9512 olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.45482 Duodenum Mucosa Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.906897 PPP1R2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.663 PHF8 ENCODE Transcription Factor Targets 1.0 null hsa-miR-2909 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 EB-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16965 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16335 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3325-01A-01R-0864-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13751 superior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.13118 UQCRH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49168 hsa-miR-4441 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GSE111247_2_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null DNAAF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93347 APEX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.68043 SHSY5Y CCLE Cell Line Gene Expression Profiles 1.0 2.63965 Lung adenocarcinoma_LUAD_TCGA-75-7025-01A-12R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.72076 striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00643 496100390_PCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.06476 GSE229671,GSE229673_3_v_1_yrdc_human RummaGEO Gene Perturbation Signatures 1.0 null stratum pyramidale of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.824048 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34219 paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05773 APOBEC3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51363 paraterminal gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.18336 GSE210682_0_v_3_methadone_human RummaGEO Drug Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.69356 COLO668 CCLE Cell Line Gene Expression Profiles 1.0 1.36711 IER2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35403 105KC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.833581 Eye-retinal bipolar neuron Tabula Sapiens Gene-Cell Associations 1.0 0.972436 EZH2 ENCODE Transcription Factor Targets 1.0 null transferase complex GO Cellular Component Annotations 2015 1.0 null PCBP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.15761 Perturb_6487_OE_MDM2_SRP302203 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.66045 Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PARP11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03587 TYK-NU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.71263 H3K4me1_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CHK2_KD_GSE54268_667_human_MCF-10A GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null TPRX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42388 TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SETBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.15779 H3K27me3_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5105166-ncomms13331-s5.xlsx-Sheet1-Supplementary_Data_4_Gene_expression_signature_of_MEF2D-rearranged_cases_stranded_data_only_MEF2D Rummagene Transcription Factor Associations 2026 1.0 null peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02248 E2F6 ENCODE Transcription Factor Targets 1.0 null PRICKLE4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45007 ZNF672 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20252 n-terminal protein acetyltransferase complex GO Cellular Component Annotations 2015 1.0 null ZMIZ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75013 Brain Lower Grade Glioma_LGG_TCGA-RY-A83Y-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NR1H2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.12 H3K4me1_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100467_FWM_probable Alzheimer's disease_no TBI_89_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.29851 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A6DV-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CAPAN1 DepMap CRISPR Gene Dependency 1.0 2.63758 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventral lateral nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3514 GSE205630_0_v_1_gmds_human RummaGEO Gene Perturbation Signatures -1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H9 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.53704 NELFB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.18391 PLPP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13455 CDK16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62033 CD177 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56563 ZNF365 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67613 VEZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.0743 TMEM256 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62057 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Amylin receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.71 496100460_TCx_possible Alzheimer's disease_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.69841 H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null QA-07-KC40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.228071 SLC12A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16258 Celiac ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.978 ATP5MJ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.289 hsa-miR-127-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GSE135514_8_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null indusium griseum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0515 PMC4470057-12943_2015_398_MOESM7_ESM.xls-probes_KD_inh_in_common-SYMBOL_AR Rummagene Transcription Factor Associations 2026 1.0 null Duodenum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CDC14C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58124 H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-885-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 OVMANA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.881216 MKN45 DepMap CRISPR Gene Dependency 1.0 4.71157 lateral hypothalamic area, anterior part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.89477 MICAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76119 SPSB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07183 NCIH1339 CCLE Cell Line Gene CNV Profiles -1.0 -1.39926 subcallosal cingulate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.8969 PAN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73861 hsa-miR-3926 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 PRDM9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 312.223 IRF2 JASPAR Predicted Transcription Factor Targets 1.0 null PPARG JASPAR Predicted Transcription Factor Targets 1.0 null MITF ChEA Transcription Factor Targets 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.7611 H3K4me1_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null LC-12-VN85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.517093 CBX8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33491 KELLY CCLE Cell Line Gene CNV Profiles -1.0 -1.69653 CL11 CCLE Cell Line Gene CNV Profiles 1.0 1.41849 USF1 ENCODE Transcription Factor Targets 1.0 null MFNG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64608 CHLA15 DepMap CRISPR Gene Dependency 1.0 4.40472 SPIN2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65284 posteroventral (inferior) parietal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.839012 ovary HPA Tissue Protein Expression Profiles -1.0 -2.09854 GSE57871_1_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null DNMT3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80589 mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25341 C32 CCLE Cell Line Gene Expression Profiles 1.0 1.5836 PLXND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.50865 E2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.1081 KYSE-510 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.833581 inferior olive, dorsal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00188 ZNF417 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.5365 RC-K8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03787 C2orf81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11998 striatum_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.932437 SG in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.72395 SPNS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73966 YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39102 VDAC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10976 Whole Blood GTEx Tissue Gene Expression Profiles 2023 1.0 4.38918 ERV3-1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34765 RGS16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.21332 PRM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91129 PDAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.25968 smooth muscle HPA Tissue Protein Expression Profiles -1.0 -2.09854 ABCC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57807 HSPB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33015 Tail fin TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.267 hsa-miR-548s TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 NFX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91138 RPL13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31567 ELF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.88635 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3HZ-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35962 GSE169152_3_v_7_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.31802 lateral subdivision of BNST Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.896317 Prostate adenocarcinoma_PRAD_TCGA-J9-A52E-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TUBA1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92201 AA-58-FJ71_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.222832 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6962-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8981_KD_MEOX2_SRP358321 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.50035 n-terminal protein amino acid acetylation GO Biological Process Annotations 2015 1.0 null MCC13 DepMap CRISPR Gene Dependency 1.0 4.56523 TFAP4::ETV1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.6131 PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_-2-1280_genes_are_more_than_four-fold_downregulated_in_PRDM8-_-_compared_to_control_PRDM8 Rummagene Transcription Factor Associations 2026 1.0 null Lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.011 PCDHB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92823 H3K27me3_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.918467 TSC22D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54937 AGXT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47511 PPM1J CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74689 GK5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71186 Basal ganglion TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.035 ZNF134 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.514 GSE214248_0_v_1_cxcl8_human RummaGEO Gene Perturbation Signatures 1.0 null GSE171352_2_v_3_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null B3GNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7156 PCDHB16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50949 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.32823 WM983B DepMap CRISPR Gene Dependency 1.0 2.26667 Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCDN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4233 FANCM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4225 IZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1171 MRPS15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12958 GSE135514_2_v_3_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null 496100399_PCx_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.04866 primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.918778 Rectal Mucosa Donor 31 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 2.48548 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.90316 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AC-92-HS43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.223848 VIRMA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2249 TUHR4TKB CCLE Cell Line Gene Expression Profiles -1.0 -2.49424 primary metabolic process GO Biological Process Annotations 2015 1.0 null H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.92039 IPC-298 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.868726 DNM1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81683 catalytic complex GO Cellular Component Annotations 2015 1.0 null H3-3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.00118 SG in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.88728 biological_process GO Biological Process Annotations 2015 1.0 null Sarcoma_SARC_TCGA-DX-A7EI-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF394 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.49514 ME-31-RM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.445758 PMM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80291 TCF12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0656 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NEMF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9128 HEY1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5594 LRRC58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94224 hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.47686 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5377 protein acetylation GO Biological Process Annotations 2015 1.0 null HDAC6 ENCODE Transcription Factor Targets 1.0 null Perturb_13855_KD_IGF2BP1_SRP284043 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 14.7657 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NDUFB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58059 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YS-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PELI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72011 ACTR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23993 anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.995239 CD40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70579 OE33 CCLE Cell Line Gene CNV Profiles 1.0 1.93288 Ribulose bisphosphate carboxylase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.753 496100630_PCx_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.99036 AIFM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38436 ventrolateral prefrontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.878317 253J CCLE Cell Line Gene Expression Profiles 1.0 1.87433 MFSD2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96215 NCI-H82 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02637 GBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53243 PPP2R5D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32861 hsa-miR-4723-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 APIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73086 COLO677 CCLE Cell Line Gene Expression Profiles 1.0 2.26174 H3K4me1_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TMEM184A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27959 stratum lacunosum-moleculare of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.995371 PMC9305137-PATH-256-297-s005.xlsx-CIC_associated_DE_genes_IDH1-W-Unnamed_1_CIC Rummagene Transcription Factor Associations 2026 1.0 null orbital frontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.907967 cellular metabolic process GO Biological Process Annotations 2015 1.0 null NOP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43024 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.897 Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-genes_with_VDR_peaks_with_and_without_D3_VDR Rummagene Transcription Factor Associations 2026 1.0 null H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.37067 NB6 DepMap CRISPR Gene Dependency 1.0 2.34376 AA-22-UI44_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.22411 BB-44-SX65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220431 ME-31-RM40_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.300346 TSC22D4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27262 PACS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40676 P2RX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7402 Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PD-70-VS77_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.402841 MALME3M CCLE Cell Line Gene CNV Profiles 1.0 1.42665 CTSZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.52277 RERFLCSQ1 CCLE Cell Line Gene CNV Profiles 1.0 1.40831 CCDC85C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2567 HERPUD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60822 Brain Lower Grade Glioma_LGG_TCGA-QH-A6X4-01A-51R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.953099 GSKIP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24383 CTNNB1-24651522-LGR5+ INTESTINAL STEM CELL-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-8469-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RNF227 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92939 Perturb_14131_KD_YAP1_SRP264810 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.16058 PRSS22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97131 NUDT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28425 GSE242555_1_v_0_fn3k_human RummaGEO Gene Perturbation Signatures 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.37067 CARD19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49425 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09926 PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S17-Table_S17_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-001_4E_vs_DMSO_RUNX2 Rummagene Transcription Factor Associations 2026 1.0 null GR-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09926 H3K4me1_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FLI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.42195 UPCISCC200 DepMap CRISPR Gene Dependency 1.0 2.31183 ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05075 JURKAT CCLE Cell Line Gene Expression Profiles -1.0 -2.01892 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A6RX-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CGGBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66713 SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.92003 CAPN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5531 GPRASP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60899 H3K14ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE191021_1_v_0_nono_human RummaGEO Gene Perturbation Signatures -1.0 null PER2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74954 PMC8656035-40001_2021_613_MOESM2_ESM.docx-66-ZNF117_ZNF117 Rummagene Transcription Factor Associations 2026 1.0 null NCIH82 DepMap CRISPR Gene Dependency 1.0 3.35513 GSE117212,GSE117214_0_v_1_zbtb1_human RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8105-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20352 substantia nigra, compact part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.55428 cytoplasmic part GO Cellular Component Annotations 2015 1.0 null NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2131 cerebral cortex HPA Tissue Protein Expression Profiles -1.0 -0.923229 H3K27me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_12_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.03452 NFKB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 73.8012 FUNDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.05659 H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-601 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858043 VI, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.892488 GSE137702_2_v_1_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null SRRM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76746 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PERP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23623 IRF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 66.6835 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RBBP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99937 primary auditory cortex (core)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.59751 RANBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34538 CERS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2097 Perturb_224_KD_YBX3_SRP289565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.08688 n-terminal protein amino acid modification GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135514_8_v_3_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ventrolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03656 SFRP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41082 SKOV3 CCLE Cell Line Gene CNV Profiles -1.0 -1.50368 Brain Lower Grade Glioma_LGG_TCGA-S9-A6WN-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFKB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.5001 RHOXF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31705 YAPC CCLE Cell Line Gene Expression Profiles -1.0 -1.76546 X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.57798 orbital frontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.94958 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.1743 NSMAF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70665 PF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86345 TBPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46002 amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.64706 posteroventral (inferior) parietal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.823919 JHOM2B CCLE Cell Line Gene Expression Profiles -1.0 -1.46378 SPIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7122 PACSIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23486 DCAF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58576 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AP-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ANKRD46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52542 TJAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14099 MVB12A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38688 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ISL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3227 upper (rostral) rhombic lip_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.88164 NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null SS18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30386 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.59659 ZIM3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.5293 ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.881341 TSHZ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75582 USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CP in caudal hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26797 HAND2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6059 dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.59251 hsa-miR-3679-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 ECE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66715 ZNF30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42077 GSE182680,GSE182683_7_v_2_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GTF2H5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3678 ASPHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71673 H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null OFD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30376 JHH2 CCLE Cell Line Gene CNV Profiles 1.0 1.42502 Brain Lower Grade Glioma_LGG_TCGA-DH-5140-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-Unnamed_35_CREB1 Rummagene Transcription Factor Associations 2026 1.0 null PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-RRHO_concordant_degree_CREB1 Rummagene Transcription Factor Associations 2026 1.0 null RPL30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38296 TMEM229A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75062 TSPAN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75252 H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEGF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.86926 WM-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29969 Attention deficit hyperactivity disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 Pancreas-pancreatic beta cell Tabula Sapiens Gene-Cell Associations 1.0 4.93611 RCAN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.95717 ATP11C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18733 NCI-H1993 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 GSE143692_0_v_1_trim8_human RummaGEO Gene Perturbation Signatures 1.0 null head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HNRNPAB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.45198 AA-58-FJ71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.400961 AR ChEA Transcription Factor Targets 1.0 null HEC251 DepMap CRISPR Gene Dependency 1.0 2.38959 OVCAR4 CCLE Cell Line Gene CNV Profiles 1.0 1.69576 VAPA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32708 Skin Cutaneous Melanoma_SKCM_TCGA-D9-A6EA-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TRIM16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13609 mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.02793 VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.859648 QA-07-KC40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220646 GSE149096_4_v_3_ascl1_human RummaGEO Gene Perturbation Signatures -1.0 null TFDP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77876 FOXH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04543 hsa-miR-3158-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40425 RMGI CCLE Cell Line Gene CNV Profiles -1.0 -1.81326 Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BATF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2774 EBAG9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73732 NCIH522 DepMap CRISPR Gene Dependency 1.0 2.54272 ATAD3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.45112 dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.35504 HCC1143 CCLE Cell Line Gene CNV Profiles -1.0 -1.47569 Brain Lower Grade Glioma_LGG_TCGA-DU-6394-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DUSP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28092 Lung squamous cell carcinoma_LUSC_TCGA-92-8063-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94666 stratum radiatum of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16216 ATG16L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66705 ZNF692 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.5888 CD2AP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59837 ACSS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2007 orbital frontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.829332 NR2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.2882 FEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47126 nucleus LOCATE Predicted Protein Localization Annotations 1.0 null hippocampus (hippocampal formation)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.14294 SUZ12 ENCODE Transcription Factor Targets 1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11173 primary auditory cortex (core)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16806 H3K27me3_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EIF3H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00877 HEYA8 CCLE Cell Line Gene CNV Profiles -1.0 -1.44195 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16335 NCIH1563 CCLE Cell Line Gene CNV Profiles -1.0 -1.57969 KG1 CCLE Cell Line Gene CNV Profiles -1.0 -2.18696 SF3B4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38846 FF-86-NH56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.400829 CHTF18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5671 superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.67234 GSE195663_7_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null SU8686 CCLE Cell Line Gene Expression Profiles -1.0 -1.67861 POU5F1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71788 CTCF ENCODE Transcription Factor Targets 1.0 null TET2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54241 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.927532 Mesothelioma_MESO_TCGA-SH-A7BD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSTA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3277 SUMO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02451 primary auditory cortex (core)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.828167 FE-29-XM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.379978 RBM12B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69398 Lassa Fever Virus_24hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.61116 JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNHIT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76061 ZIC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12611 DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.426521 SKNEP1 DepMap CRISPR Gene Dependency 1.0 2.06511 ZNF804A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90888 PMC10260405-41588_2023_1409_MOESM6_ESM.xlsx-ST12-Supplementary_Table_12_Most_likely_causal_genes_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null TBP ENCODE Transcription Factor Targets 1.0 null PITPNC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.887 Lung adenocarcinoma_LUAD_TCGA-62-A472-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PATZ1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 383.425 B3GNT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59135 PARP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17428 JHH4 CCLE Cell Line Gene Expression Profiles 1.0 1.45258 Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 UBALD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17344 T-lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.011 GIPC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.29381 FANCI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67412 primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.73036 PIPOX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75083 YIPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6571 Hematopoietic cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.011 RELL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32824 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TMEM52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47065 HNRNPCL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63707 EIF4A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65988 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KLF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 238.363 EPM2AIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.19005 TERT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31731 Prostate adenocarcinoma_PRAD_TCGA-KK-A7B0-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OCIAML3 DepMap CRISPR Gene Dependency 1.0 6.12226 PMC4791243-oncotarget-06-43452-s006.xlsx-Supplementary_table_S5-Supplementary_table_S5_Differentially_expressed_genes_in_TP53_mutant_versus_TP53_wild_type_cell_lines_TP53 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SUDHL8 DepMap CRISPR Gene Dependency 1.0 3.56323 TLE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33306 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NALM6 DepMap CRISPR Gene Dependency 1.0 6.75215 Prostate adenocarcinoma_PRAD_TCGA-J9-A52B-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MT-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03787 Perturb_338_OE_PBX1_SRP389513 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 17.9101 WASL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22997 XXYLT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.704 ZNF709 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50795 HEXD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09092 lateral habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06281 TSPYL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5839 KLF14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 204.322 ROMO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06257 TSR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8845 Acute Myeloid Leukemia_LAML_TCGA-AB-2849-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF205 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12763 MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07493 IPO7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99898 CSRNP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99177 PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.64266 ECC10 CCLE Cell Line Gene Expression Profiles 1.0 1.71866 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 hsa-miR-423-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 496100586_HIP_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.88804 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null brain GTEx Tissue Gene Expression Profiles 1.0 1.1187 Brain Lower Grade Glioma_LGG_TCGA-S9-A6WH-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE112714_2_v_0_ctnnb1_human RummaGEO Gene Perturbation Signatures 1.0 null ADAM11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69176 NCCSTCK140 CCLE Cell Line Gene Expression Profiles -1.0 -1.83306 SCMH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12993 protein complex GO Cellular Component Annotations 2015 1.0 null PPP2R5C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08814 RUVBL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48033 SKCO1 CCLE Cell Line Gene CNV Profiles 1.0 1.80844 GADD45GIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35177 CAL148 CCLE Cell Line Gene Expression Profiles -1.0 -1.7651 GSE235701,GSE261434_0_v_3_enasidenib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE167224,GSE168147_3_v_5_hnrnpk_human RummaGEO Gene Perturbation Signatures 1.0 null ARID1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72453 H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null DNTTIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.06552 NDUFB5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57415 orbital frontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.850568 RNH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.325 primary motor-sensory cortex (samples)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.49685 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null ZNF236 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29257 MESSA CCLE Cell Line Gene CNV Profiles -1.0 -1.82454 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.978309 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6937-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Specific developmental disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 hippocampus (hippocampal formation)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.923763 inferior colliculus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.854296 III, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.827035 EZH2_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF112 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74484 MIER2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92521 PIGP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3446 ACTG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18333 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.871154 DTX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.32094 AP-1 MotifMap Predicted Transcription Factor Targets 1.0 null AB-97-BI36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.246271 H3K27me3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11255 HDAC2 ENCODE Transcription Factor Targets 1.0 null TT2609C02 DepMap CRISPR Gene Dependency 1.0 2.12271 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.934456 PNKD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.53877 GSE239688_2_v_5_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null basolateral nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.984924 H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-5899-01A-11R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF677 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46827 organelle LOCATE Predicted Protein Localization Annotations 1.0 null MBD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87141 hsa-miR-1275 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 amygdaloid complex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.35504 dorsolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37268 PVR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.6928 MSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74546 TM9SF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8779 LSS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25209 EVX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16297 SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.64744 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H2-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PTMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26185 USF2 ENCODE Transcription Factor Targets 1.0 null ZDHHC11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.98873 H3K27me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.00049 DACT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94563 PLC/PRF/5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46535 H3K4me1_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null THOC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11415 inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.944022 METTL21C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65522 RBFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57277 mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.842063 PKMYT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19857 hsa-miR-4432 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 EPLC272H CCLE Cell Line Gene CNV Profiles 1.0 2.13994 ECC12 CCLE Cell Line Gene Expression Profiles -1.0 -2.801 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.09389 SG in midlateral extrastriate cortex (area 19) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42522 RUNX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56027 cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.38295 PPARD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0286 cerebellum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.962997 ISHIKAWAHERAKLIO02ER DepMap CRISPR Gene Dependency 1.0 4.00359 PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null salivary gland HPA Tissue Protein Expression Profiles 1.0 1.4499 GEN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.54516 ATF2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D Rummagene Transcription Factor Associations 2026 1.0 null RHBDL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50831 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4342-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null metabolic process GO Biological Process Annotations 2015 1.0 null hsa-miR-939 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 PMC6855629-pone.0225186.s008.xlsx-Sheet1-DEGs_downregulated_in_SK-N-SH_MEIS1_OE_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null ZNF530 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 91.7586 496100421_PCx_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.79878 ARHGAP19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82534 CCDC90B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77832 SIX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73998 posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12413 NOTO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27484 MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858043 PAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.835 C19orf44 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13757 SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.08351 SNU5 CCLE Cell Line Gene CNV Profiles 1.0 2.07551 ZNF274 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18775 HS936T CCLE Cell Line Gene Expression Profiles 1.0 1.6993 EBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IZ in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03926 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08991 ZNF212 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75776 central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.964457 YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CE-96-GH46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.254889 orbital frontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.85335 cerebellum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.57063 Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.988952 SZ in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.917277 HSD11B1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00463 MMP25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41682 transferase activity GO Molecular Function Annotations 2015 1.0 null GSE230744,GSE237803_5_v_3_hira_human RummaGEO Gene Perturbation Signatures -1.0 null PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07807 DU 145 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null NUP37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18627 ventromedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04374 CAL29 CCLE Cell Line Gene CNV Profiles 1.0 1.98277 ZFP91 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64534 NMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23488 GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Amylin receptor complex 1 COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.799 LN443 CCLE Cell Line Gene Expression Profiles 1.0 2.14985 ABHD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16737 EBC1 CCLE Cell Line Gene CNV Profiles 1.0 2.25386 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RING1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61569 RMUGS CCLE Cell Line Gene CNV Profiles -1.0 -1.38384 GLCCI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58724 ZDHHC18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47365 SLC52A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15578 Brain Lower Grade Glioma_LGG_TCGA-DU-6400-01A-12R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216273,GSE216292_14_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE242555_1_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8001-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRKD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24307 BD-18-MM33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.267352 oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.42376 OCIAML2 CCLE Cell Line Gene Expression Profiles -1.0 -1.66908 H3K27me3_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null OB-06-WW76_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.215256 basomedial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.49343 POLR1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88402 CL11 CCLE Cell Line Gene Expression Profiles 1.0 1.45391 Osteoarthritis_Chondrocyte_GSE16464 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.95738 organic substance metabolic process GO Biological Process Annotations 2015 1.0 null ZMYM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51593 FERD3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03761 PMS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47788 ZNF675 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.8128 Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66S-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01972 Kidney Chromophobe_KICH_TCGA-KN-8433-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZXDC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3455 amygdalohippocampal transition zone, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0253 ZNF497 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92643 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3467-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TGBC11TKB CCLE Cell Line Gene Expression Profiles -1.0 -1.95886 H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-198 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 GSE111247_0_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null TRIM25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19522 GSE206729_3_v_1_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null SP in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06284 LBR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56337 TE8 CCLE Cell Line Gene Expression Profiles -1.0 -1.46294 GSE57871_1_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null NAMALWA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16965 H4C5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.57907 DOHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16965 PMC7914369-thnov11p3676s2.xls-BPTF-KOvsCtrl-AccID_BPTF Rummagene Transcription Factor Associations 2026 1.0 null X Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1437 G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.40619 ZC3H8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02349 GE-47-OO30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.319657 PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-1n_h-r__CIC-2n_h-r_CIC Rummagene Transcription Factor Associations 2026 1.0 null LRRC55 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76515 RAB35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.756 Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.53927 PBX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32791 C32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.7408 NOD2 Pathway Commons Protein-Protein Interactions 1.0 null PRXL2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39772 MALME3M CCLE Cell Line Gene Expression Profiles 1.0 1.51191 H3K27me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFAP2E JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.0252 orbital frontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.862058 REST ENCODE Transcription Factor Targets 1.0 null GSE162892_3_v_0_sox9_human RummaGEO Gene Perturbation Signatures 1.0 null CD9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7503 URB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.061 PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A Rummagene Transcription Factor Associations 2026 1.0 null RGS12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71152 GCDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9648 posterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27728 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NAB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12169 NR2C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.3128 SEMK2 DepMap CRISPR Gene Dependency 1.0 2.61491 GSE142210_3_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null thyroid GTEx Tissue Gene Expression Profiles 1.0 0.865608 RRP36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03985 GSE226584,GSE226589_2_v_0_ezh2_human RummaGEO Gene Perturbation Signatures 1.0 null IRF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7305 cellular process GO Biological Process Annotations 2015 1.0 null GRTP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96362 OTULINL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77083 protein modification process GO Biological Process Annotations 2015 1.0 null VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.11889 H3K4me1_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Down_bins-Down_bins_loosing_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null SRSF11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95777 EDEM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56139 primary motor cortex (area M1, area 4)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.36269 H3K9me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SLU7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10788 UBFD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79006 ATF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77652 LC-12-VN85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.296231 DPM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65991 BB-42-FF52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.255045 Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MED22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63369 H2BC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38932 NCIH3255 CCLE Cell Line Gene CNV Profiles 1.0 1.35666 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZFP57 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6388 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2855-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SG in dysgranular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04882 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19562 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A556-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH510 DepMap CRISPR Gene Dependency 1.0 2.25739 primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24972 SNU466 CCLE Cell Line Gene CNV Profiles 1.0 1.68444 AA-58-FJ71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.410403 VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.942394 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF555 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56455 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5697-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SOX30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92922 HEL CCLE Cell Line Gene Expression Profiles -1.0 -1.49317 GAPVD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42448 Lung adenocarcinoma_LUAD_TCGA-05-4396-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100623_PCx_no dementia_TBI_86_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.0961 RASD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65596 GATAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.97155 RNF113A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65834 Perturb_17546_KD_STAT3_SRP354633 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 NMU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32621 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65048 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.59265 EDEM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91128 Nucleus lentiformis TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.035 BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832799 FERMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45007 primary motor cortex (area M1, area 4)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22996 protein acylation GO Biological Process Annotations 2015 1.0 null H3K23me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FC-20-EQ58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.285565 METTL21A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2918 Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.49821 TRMT2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29462 TWNK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40519 BATF::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.385 CD320 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99887 GIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.33838 H2AFZ ENCODE Transcription Factor Targets 1.0 null Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Prostate adenocarcinoma_PRAD_TCGA-HC-8262-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.26615 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null N-terminal protein acetyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.736 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AA-23-FM46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.249155 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null striatum_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.09604 SLF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2663 THUMPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.15321 BSDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99994 Prostate adenocarcinoma_PRAD_TCGA-CH-5751-01A-11R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cytotoxic T-lymphocyte TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.011 CA4 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33793 inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35214 PMC13137955-ijbsv22p4243s2.xlsx-Sheet1-hTFtarget_E2F3_E2F3 Rummagene Transcription Factor Associations 2026 1.0 null SNU13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8138 ACSM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.16653 NCI-SNU-5 COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 PPARGC1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64595 CA4 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.912082 YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.84278 mediodorsal nucleus of thalamus_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.33451 H4K91ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCIH2228 CCLE Cell Line Gene CNV Profiles -1.0 -1.53769 MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF669 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 57.745 Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3383-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF140 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.9815 HC-74-HM63_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.416494 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IV Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.981166 PTPRG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45267 JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08788 NDFIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8045 LF-94-HB11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.461275 PPP6R2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.56784 LN464 CCLE Cell Line Gene Expression Profiles 1.0 1.98508 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.981005 Brain Lower Grade Glioma_LGG_TCGA-DU-6392-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.977136 C11orf96 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.17346 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF300 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90116 C8orf82 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35718 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null CAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12856 Von Willebrand's disease 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.559 LRRC20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09783 Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.853379 Erythroid cell TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.002 EXOSC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27937 ZNG1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78622 NPEPPS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85424 H3K27me3_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100395_TCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.02236 VIIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.58066 superior colliculus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.08991 GSE216273,GSE216292_0_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null ETV5::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.3053 CREB1 ENCODE Transcription Factor Targets 1.0 null cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QH-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.913729 ZNF85 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.19892 CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HG3 DepMap CRISPR Gene Dependency 1.0 2.25032 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.77976 CANX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12012 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31791 EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A5R9-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TADA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8895 KLF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 191.126 RAMOS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.16965 DZIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.96722 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BATF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6225 RPL6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.65988 PLAG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 120.556 TSPOAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52812 PMC8995879-Table_1.xlsx-exome_variants_MAF_0_01-Gencode_34_hugoSymbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null Pituitary GTEx Tissue Gene Expression Profiles 2023 1.0 2.07394 ANXA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.7076 XYLT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84754 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null CCNI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58838 NTMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29191 H3K4me1_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ventral posterior inferior nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08378 PRKAA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13192 KO52 CCLE Cell Line Gene CNV Profiles -1.0 -2.14198 ZNF816 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.8082 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null UTP20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96201 ZDHHC19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74068 PMC7064337-elife-51373-supp1.xlsx-MTF2_targets_shCTR-List_of_2011_genes_marked_by_MTF2_ChIPseq_in_control_conditions_shCTR_MTF2 Rummagene Transcription Factor Associations 2026 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I5-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD46 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24435 ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06171 UBA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75001 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87317 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5454-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.0675 ZNF707 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.64174 ATP6AP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9347 BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.462844 H3K4me1_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40337 H3K4me1_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ANKS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.32524 EJM DepMap CRISPR Gene Dependency 1.0 8.6612 ZNF827 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75965 NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.858043 UBAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3063 PE/CA-PJ15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3685 H3K27me3_cardiac mesoderm_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.52365 SNU1327 DepMap CRISPR Gene Dependency 1.0 2.7452 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00218 oral mucosa HPA Tissue Protein Expression Profiles 1.0 1.4499 cellular_component GO Cellular Component Annotations 2015 1.0 null HS 69ST Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.79604 ANAPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33777 WFS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3688 CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.64274 Rectum adenocarcinoma_READ_TCGA-AF-4110-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BLTP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17486 Metallochaperone complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.949 NCIH2106 CCLE Cell Line Gene Expression Profiles 1.0 1.58061 TMEM126A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91048 ACACA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27565 JHOS2 CCLE Cell Line Gene CNV Profiles -1.0 -1.57553 NF-21-HQ00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.215247 CD2BP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90697 H3K27me3_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null JUN::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.1556 NT5DC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.68638 GSE176144_0_v_1_zfc3h1_human RummaGEO Gene Perturbation Signatures 1.0 null DF-75-OU25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.212677 ETS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08153 DLX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.98905 GSE206729_2_v_1_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null TIMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21922 HELB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56073 SLC25A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.94352 YY1 ENCODE Transcription Factor Targets 1.0 null PTPRA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54573 SP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 207.023 H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ORMDL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46607 647V DepMap CRISPR Gene Dependency 1.0 2.59296 intracellular part GO Cellular Component Annotations 2015 1.0 null PMC8616957-41467_2021_27270_MOESM4_ESM.xlsx-Sheet1-Supplementary_Data_1_Differentially_expressed_genes_FDR_0_05_edgeR_exact_test_in_MLL-AF4_infant-ALL_vs_MLL-AF4_childhood-ALL_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null STX7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47195 granular layer of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.30852 NPAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.13431 H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PNMA6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48356 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00013 anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.24485 PICK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77277 BZW2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74832 lateral hypothalamic area, mammillary region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.857831 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.11485 TMEM115 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61758 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4859-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCNN1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35832 cisplatin_homo sapiens_gpl570_gse23553 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AKAP12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23577 Pancreas-pancreatic delta cell Tabula Sapiens Gene-Cell Associations 1.0 0.506122 primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.30022 FASTKD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20835 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11255 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 POLR2J2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14048 ZFAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99516 RARA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.2485 MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE14 CCLE Cell Line Gene Expression Profiles -1.0 -1.60265 GABPA ENCODE Transcription Factor Targets 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7920-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-A8OV-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE111247_11_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27me3_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SBF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.80218 PK-45P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11075 HUH28 CCLE Cell Line Gene Expression Profiles 1.0 1.65537 QPCTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47348 ZMPSTE24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0245 spleen HPA Tissue Protein Expression Profiles -1.0 -1.23479 JUND ENCODE Transcription Factor Targets 1.0 null ZXDA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27003 PDS5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78285 ZDHHC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11158 FMNL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33753 SLC25A38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42891 Mesothelioma_MESO_TCGA-NQ-A57I-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.93103 Ganglion TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.035 OE33 DepMap CRISPR Gene Dependency 1.0 2.2537 ZNF704 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09562 ZNF454 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 138.894 ARPC1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04641 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MLMA COSMIC Cell Line Gene CNV Profiles 1.0 2.64759 Adrenocortical carcinoma_ACC_TCGA-OR-A5J3-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF876P CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93129 LHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29919 anterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01154 ZNF701 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 70.6999 CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.60066 MAN1B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82251 ECHS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13298 PMC11046918-12967_2024_5211_MOESM4_ESM.xlsx-F_HT1080_FUS-DDIT3_regulated-Table_S2_Regulated_genes_between_scaffold-cultured_and_monolayer-cultured_cells_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null VI, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.26904 RBBP5 ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-73-4668-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NPW CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53963 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5706-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CCDC88A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12735 HMGA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24509 POLR2D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74357 JAG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16874 MZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.36749 H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FBXO6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4544 GSE153443_1_v_2_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_15238_KD_TINCR_SRP082178 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -16.3499 Cranial nerve TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.006 DBN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34007 H1-7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.99308 IZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11998 H3K27me3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NUDHL1 CCLE Cell Line Gene Expression Profiles 1.0 3.40797 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LEDGF_KD_GDS1580_249_human_293T cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null posterior (caudal) superior temporal cortex (area 22c)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.857395 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.37584 Brain Lower Grade Glioma_LGG_TCGA-P5-A5F0-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE213588_10_v_11_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.967548 Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TC138 DepMap CRISPR Gene Dependency 1.0 2.29366 DGCR6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.321 ONDA9 DepMap CRISPR Gene Dependency 1.0 2.6608 Perturb_3911_KD_SOX9_SRP118481 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.51152 CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.49303 VIIB, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04006 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45U-01A-12R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DDX42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.24594 hsa-miR-4639-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 TSSC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21554 LYRM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.95925 Brain Lower Grade Glioma_LGG_TCGA-FG-A87N-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33342 CNMD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02791 GSE178907_0_v_3_fkrp_human RummaGEO Gene Perturbation Signatures -1.0 null GSE213588_10_v_5_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null UBR3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81305 GSE190316,GSE190324_6_v_9_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null MDP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.76759 chr7_101170753_C_T_b38 GTEx eQTL 2025 1.0 2.71035 MGME1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18126 SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.92003 QF-71-QI30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.201493 hsa-miR-4505 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 ANGEL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01575 CA-68-KG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.208946 NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09926 VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.29833 ZZEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0377 H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RV-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MRPL22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46812 HIGD1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48332 Crus I, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.942971 Globus pallidus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.035 TRMT5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49529 IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19261 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09404 AA-22-UI44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.416868 Lung adenocarcinoma_LUAD_TCGA-49-6761-01A-31R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.978309 PIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66409 THAP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33347 MXI1 ENCODE Transcription Factor Targets 1.0 null HS 695T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.966493 GFI1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92993 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FOXD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40629 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RNASE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95184 RELA JASPAR Predicted Transcription Factor Targets 1.0 null GSE205730,GSE205731_2_v_1_tazemetostat_human RummaGEO Drug Perturbation Signatures 1.0 null ZBTB25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31552 MIEF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.40394 anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21226 UKE-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.00049 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GID4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47758 ventrolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05481 ZNF281 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 390.859 primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.42385 Brain Lower Grade Glioma_LGG_TCGA-HT-8012-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBPJL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72889 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z3-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null molecular_function GO Molecular Function Annotations 2015 1.0 null ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28065 UNCX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03863 CABLES1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9927 RAB34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54239 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.16171 CCC5 DepMap CRISPR Gene Dependency 1.0 8.55706 SG in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.75902 COA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27302 GSE188458_2_v_1_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PHAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28471 primary motor-sensory cortex (samples)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.874006 TRPS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51952 EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4142 posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.50565 PKP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85391 EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.355266 GSTO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26891 KG-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.833581 ACVR2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91231 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FM-8000-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE185519_4_v_7_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4 Rummagene Transcription Factor Associations 2026 1.0 null HIC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13165 PCNX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.41109 MORF4L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82037 SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.972772 PMC7176284-pcbi.1007753.s008.xlsx-2_MYCN-NA_NBL_Multimodal_Genes-gene_MYCN Rummagene Transcription Factor Associations 2026 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null DCUN1D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76639 EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEP290 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96754 GSE146982_7_v_5_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null subthalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.77882 ATP1B3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66956 496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.0825 TGFBR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91576 ORAI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14238 BCL2L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58168 Inner kinetochore COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.664 RPS4Y1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40822 VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.88857 SCC4 CCLE Cell Line Gene CNV Profiles 1.0 2.59483 AB-97-BI36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.20729 TRAPPC8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34575 Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95296 CTCFL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.2208 NEUROD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01735 dorsolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.912899 centromedian nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30436 Perturb_13930_OE_DLG2_ERP119345 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 15.0451 ZNF586 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13583 PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null H2AL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28258 EVSAT CCLE Cell Line Gene CNV Profiles 1.0 1.76504 III Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.884971 NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION ChEA Transcription Factor Targets 2022 1.0 null SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A59Z-01A-12R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRMS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06098 PPM1F CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.76344 MKN7 CCLE Cell Line Gene CNV Profiles -1.0 -1.3346 WB-48-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.244423 DARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59513 posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.933712 KMS26 CCLE Cell Line Gene Expression Profiles 1.0 1.46375 Mis6-Sim4 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.175 IM-95M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.92003 GSE169152_3_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-3195 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GSE213650_3_v_1_everolimus_human RummaGEO Drug Perturbation Signatures -1.0 null BC-25-VR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.561669 TCEA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70216 RMGI CCLE Cell Line Gene Expression Profiles 1.0 1.34891 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.73835 USF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF318 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93801 TWIST1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32192 RERFLCSQ1 DepMap CRISPR Gene Dependency 1.0 2.2393 496100659_PCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.01087 primary auditory cortex (core)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12522 hsa-miR-138 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GBGT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12307 CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2131 natb complex GO Cellular Component Annotations 2015 1.0 null EGR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98549 Kidney Chromophobe_KICH_TCGA-KO-8414-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EE-03-SG02_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.255807 PLEC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18653 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CB-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09926 BC-54-ON71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.214571 CCNDBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42455 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4707-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Fin TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.988 MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35119 Acrosomal matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.237 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25008 H3K4me1_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K36me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68014 RNF181 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36481 PTMA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55457 lateral group of nuclei, right, dorsal division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.11385 ATF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5711 Serum metabolite levels GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.30458 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null THAP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.7375 PSN1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.918467 DAAM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90324 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MT-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.97013 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4747-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 SNU1033 CCLE Cell Line Gene Expression Profiles -1.0 -3.28059 Slow muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.91 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100327_PCx_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.91413 C1GALT1C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37385 hsa-miR-4665-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 LYPLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.05876 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70V-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null septal nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.996583 n-terminal peptidyl-methionine acetylation GO Biological Process Annotations 2015 1.0 null PRKAR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.80875 KDM3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.32211 MRPS10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86335 IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.72257 KE-37-MN32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.219072 DYNC1LI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8316 Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.68215 ZNF653 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41953 YA-78-MS95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.336973 496100647_TCx_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.1937 PRDM13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38787 C11orf71 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18014 OVMIU DepMap CRISPR Gene Dependency 1.0 6.86926 C5orf34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39426 SCARF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.0346 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19656 C32 CCLE Cell Line Gene CNV Profiles 1.0 1.98092 MPND CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23914 MCIXC DepMap CRISPR Gene Dependency 1.0 4.41215 RCOR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.78645 IQSEC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56086 TUHR14TKB DepMap CRISPR Gene Dependency 1.0 4.12072 H3K4me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null IDH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88101 Lung adenocarcinoma_LUAD_TCGA-67-3771-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF416 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.2435 EIF2AK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80688 Perturb_8809_KD_FLNA_SRP318361 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 SMAD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.74283 TE6 CCLE Cell Line Gene CNV Profiles -1.0 -1.86065 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A551-01A-21R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.18861 PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR Rummagene Transcription Factor Associations 2026 1.0 null ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.61464 CDK10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03474 E2F6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.2164 Lung adenocarcinoma_LUAD_TCGA-91-8497-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PGK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77099 CWC15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61678 LF-94-HB11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.232595 PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12 Rummagene Transcription Factor Associations 2026 1.0 null Lung adenocarcinoma_LUAD_TCGA-64-5815-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE202434,GSE202438_10_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE185519_4_v_0_gilteritinib_human RummaGEO Drug Perturbation Signatures 1.0 null NDOR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.70715 I-II Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12622 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.59169 T-47D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21391 GSE202434,GSE202438_7_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158743_1_v_2_nfkbia_human RummaGEO Gene Perturbation Signatures 1.0 null AC-76-JB92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.408477 HSPG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42019 KMT2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31571 Lung adenocarcinoma_LUAD_TCGA-38-4625-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.928325 KPTN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48129 Breast - Mammary Tissue GTEx Tissue Gene Expression Profiles 2023 1.0 4.25016 ZNF319 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17244 MBD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95527 GSE153871_1_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures 1.0 null VPS35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21934 GSE113817_2_v_1_bach1_human RummaGEO Gene Perturbation Signatures -1.0 null SLC4A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47843 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03671 primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.82302 EN DepMap CRISPR Gene Dependency 1.0 2.64811 PMC7773934-Table_1.XLSX-Table_S2-Supplementary_Table_2_TBX22_co-expressed_genes_detailed_results_TBX22 Rummagene Transcription Factor Associations 2026 1.0 null ZNF597 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00691 SHISA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.43111 midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1564 HOXD12::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.1269 JMJD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.20828 GF-35-IT27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.236259 DGKE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3781 hippocampus (hippocampal formation)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0302 cell part LOCATE Predicted Protein Localization Annotations 1.0 null PRPSAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0572 DRGX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.48634 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.21093 H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF574 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.1808 OVCAR-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.878925 Brain Lower Grade Glioma_LGG_TCGA-DB-A75K-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7871-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216273,GSE216292_0_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.29023 CCNB1IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32531 TCEAL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58548 TXNDC16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9638 VAX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70224 METTL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.162 JUND_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33957 ZNF506 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4353 GSE178532_1_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null NCIH322 CCLE Cell Line Gene CNV Profiles -1.0 -2.30528 NMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70284 BMAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.29187 Respiratory Tract Diseases CTD Gene-Disease Associations 1.0 1.09011 H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null JHUEM1 DepMap CRISPR Gene Dependency 1.0 2.27792 GSE180185_9_v_8_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null CMK115 DepMap CRISPR Gene Dependency 1.0 7.8522 UPF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.12466 496100513_TCx_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.09199 stratum pyramidale of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25376 HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.92686 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null D283MED CCLE Cell Line Gene CNV Profiles -1.0 -1.87592 PMC7373278-pone.0236187.s013.xlsx-MDA231genes_overexpressed_in_AR-Gene_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null SF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7969 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.903977 SET2 CCLE Cell Line Gene CNV Profiles -1.0 -1.53367 LARP1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94568 TRIM21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.9329 primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.93945 59M CCLE Cell Line Gene CNV Profiles -1.0 -1.45686 HNRNPC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.88249 VPS33A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31214 ZNF534 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77624 CORL47 CCLE Cell Line Gene Expression Profiles 1.0 1.70929 GSE167956_1_v_0_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null ARL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33745 SCO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40257 MRPL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77974 VPS37A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35111 TE9 DepMap CRISPR Gene Dependency 1.0 2.6651 amygdalohippocampal transition zone, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.052 TEAD4 ENCODE Transcription Factor Targets 1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE233679_5_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null primary motor cortex (area M1, area 4)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1513 NCIH1838 CCLE Cell Line Gene Expression Profiles 1.0 1.44842 GSE135514_2_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null DNMT3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04158 MANSC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00812 WAOSEL DepMap CRISPR Gene Dependency 1.0 2.04893 RELA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.1667 H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11173 Pancreas-pancreatic alpha cell Tabula Sapiens Gene-Cell Associations 1.0 0.272964 CDCA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66888 XRCC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.77053 CAMKMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75574 GSE97352_1_v_2_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null upper (rostral) rhombic lip_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.947738 IQCB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62971 mediodorsal nucleus of thalamus_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.34697 Developmental disorder of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.999 EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.866335 G61 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.927532 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null AMOTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38377 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45301 Prostate adenocarcinoma_PRAD_TCGA-KK-A8I9-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ADSS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78001 ASXL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.23051 H3K27me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9882185-media-4.xlsx-Neuron_KD-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null WC-09-GD62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.309805 KMT2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45216 ATAD3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.00567 hsa-miR-4697-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 DBT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73106 chromosome, subtelomeric region COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.327 hsa-miR-645 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 primary auditory cortex (core)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05553 SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.918467 RUNX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29435 GSE157036,GSE166411_3_v_1_halofuginone_human RummaGEO Drug Perturbation Signatures 1.0 null DUS1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52379 PDCL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27392 HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02637 DRD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72037 VIIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.881162 TMSB10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.94139 FRS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5715 ZBTB7A ENCODE Transcription Factor Targets 1.0 null VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.988844 HD-29-LW24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.231643 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LMBR1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28878 HADHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2757 AR-20517297-VCAP-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null PMC12179525-mmc1.xlsx-Group_HNF4A_vs_Null_sign-Supplemental_Table_S1_Differentially_expressed_genes_in_HNF4A-transduced_cells_vs_Null_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-7897-01A-21R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7064337-elife-51373-supp1.xlsx-SUZ12_targets_shPHF19-List_of_567_genes_marked_by_SUZ12_ChIPseq_iafter_PHF19_KD_shPHF19_AR Rummagene Transcription Factor Associations 2026 1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Grm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.735 FUCA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06291 FUZ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14123 Perturb_13905_KD_DAZAP1_SRP102807 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.75198 B4GALNT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1503 primary motor cortex (area M1, area 4)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.60638 FXYD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27057 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-6027-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF93 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 127.968 medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27204 primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -3.00281 MKNK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89495 PACS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06337 Adrenocortical carcinoma_ACC_TCGA-OR-A5JJ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4325-01A-02R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MED29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14503 inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21906 PMC7925689-41467_2021_21687_MOESM10_ESM.xlsx-A_HIF1A-Unnamed_8_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null RCN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20589 GABRG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38282 NRIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15024 EIF5AL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60724 ZNF605 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18337 striatum_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.00256 AB-74-VK99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.211939 Methionine adenosyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.851 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BD-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.84807 paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.29276 hsa-miR-4492 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 ZNF700 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12127 GNAT domain InterPro Predicted Protein Domain Annotations 1.0 null retroparafascicular area of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.919356 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4N-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RIPK2 Pathway Commons Protein-Protein Interactions 1.0 null BICR16 CCLE Cell Line Gene CNV Profiles 1.0 1.51405 TAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84805 VCY1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40782 GSE216273,GSE216292_14_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21391 496100361_TCx_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.42013 hippocampus (hippocampal formation)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11094 GSE144500_8_v_6_ventx_human RummaGEO Gene Perturbation Signatures 1.0 null FZD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87386 TBX20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17671 SU-DHL-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30413 AMOTL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01355 VD-76-SO91_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.32421 anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.08722 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HILPDA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39002 macromolecule modification GO Biological Process Annotations 2015 1.0 null Primary T cells from cord blood Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.05996 H3K27me3_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null hsa-miR-3922-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Perturb_12628_KD_CYGB_SRP388176 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.71549 RDH14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.31262 primary motor-sensory cortex (samples)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.51518 FAN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45107 MAD2L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74112 primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.91206 SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.868726 Prostate adenocarcinoma_PRAD_TCGA-EJ-5494-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZC3H13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87998 GSE162892_3_v_1_isox_human RummaGEO Drug Perturbation Signatures 1.0 null OUMS27 CCLE Cell Line Gene CNV Profiles 1.0 1.44759 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5681-11A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MUC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.33433 Brain Lower Grade Glioma_LGG_TCGA-HT-A619-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TOR1AIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.93333 hsa-miR-4749-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 PALM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15885