association	dataset	threshold value	standardized value
BRD-K83833383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39006
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
layer 6a of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05867
TGDS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04026
MPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72316
BAZ1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7048
RXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92334
Anterior olfactory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.2713
FAM72D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87484
TAOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94613
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAL1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NCIN87	CCLE Cell Line Gene Expression Profiles	-1.0	-1.88942
chemdependency	GAD High Level Gene-Disease Associations	1.0	0.295739
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
abnormality of carbohydrate metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.281141
GPC3	Pathway Commons Protein-Protein Interactions	1.0	null
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1431
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
heparan sulfate sulfotransferase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K56125296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44765
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9598
BRD-K45343543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12309
PMC11193738-41467_2024_48647_MOESM8_ESM.xlsx-Data_S5-Data_S5_HNF4A-bound_gene_targets_identified_from_ChIP-Seq_in_hepatic_cells_D8_Hep_and_HepG2_cells_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1127
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K42966513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24655
P2RY11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07334
layer III of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00694
MALL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23462
BRD-K33869336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15984
RNF103	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09066
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K21059010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52002
CRCGN015_MCF10A_48H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00565
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
TCF4	ChEA Transcription Factor Targets	1.0	null
Perisynaptic space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.508
nervous system disease	GWASdb SNP-Disease Associations	1.0	0.164967
BRD-K72029544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44204
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
snoutepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.926749
TLDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1454
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04837
BRD-K28694162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3463
layer 1 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69672
CBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23501
496100510_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.61632
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.24186
PAX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1181
outer CP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.845728
layer 4 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26002
SUPHD1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6771
ACER3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.17821
SMIM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78483
CP67-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_16895_KI_Htt_SRP250656	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.78904
EZH2	ENCODE Transcription Factor Targets	1.0	null
pyramidal layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.6023
Alcohol-Related Disorders	HuGE Navigator Gene-Phenotype Associations	1.0	null
LHX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67007
MITF	ChEA Transcription Factor Targets	1.0	null
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5696
CCNA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52615
p1 part of the substantia nigra reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25418
CRCGN010_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01892
colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091743
TP53-18474530-U2OS-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
KP-N-RT-BM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A69950438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22153
PEBP1_KO_GSE31150_52_mouse_pancreas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8S8-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH716	CCLE Cell Line Gene Expression Profiles	1.0	1.90628
VWA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74649
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
OCI-AML5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DGKE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3781
oval paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21353
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1YW-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	0.966054
GSE211474,GSE212779_8_v_2_phf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TYK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89744
pyramidal layer of taenia tecta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15831
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.18352
PEER	CCLE Cell Line Gene CNV Profiles	1.0	1.83508
Brain Lower Grade Glioma_LGG_TCGA-DU-5874-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100656_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17189
ZNF750	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91298
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-BrtoFay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K37062347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09323
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21671578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17856
Perturb_12157_KD_LIN28/LIN28A1_SRP061243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.51644
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TGIF2LY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75684
Lung adenocarcinoma_LUAD_TCGA-44-7669-01A-21R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2029	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K16479784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05288
posteromedial visual area, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30976
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ST6GALNAC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05547
PMC11185762-media-2.xlsx-ATAC2wk_KD_V337M_intersect_peak-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ACSL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61999
RAB3GAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88741
IRF2BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4221
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.247471
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
A704	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE109285_5_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7624
SVBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72303
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_14_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.183407
Lhx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.8414
GLOD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03445
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8260791-41467_2021_24345_MOESM4_ESM.xlsx-NOT_MODULAR_GENES_DISEASE_LOCI-Gene_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
FBXL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04517
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.49733
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A673	CCLE Cell Line Gene Expression Profiles	1.0	1.62543
periventricular stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14266
Anterior cingulate area, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.09078
HCFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14239
Prostate adenocarcinoma_PRAD_TCGA-VP-A87B-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0975
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5308
ARL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79443
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.894106
Medial amygdalar nucleus, posterodorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17854
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PTOV1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82067
mantle zone of the IG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.4066
Entorhinal area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.72497
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82611
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
abnormality of head or neck	GWASdb SNP-Phenotype Associations	1.0	0.096849
BRD-K09144377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43715
trastuzumab_homo sapiens_gpl570_gse15043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pyramidal layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01112
paraventricular nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16543
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
arcuate nucleus of medulla, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.93717
superficial stratum of isBI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10906
BRD-K86050213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1688
bmp receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.485289
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC7435699-mmc5.xls-Gene_lists-MITF_ChIP_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
SDC4	Pathway Commons Protein-Protein Interactions	1.0	null
Defective EXT2 causes exostoses 2	Reactome Pathways 2014	1.0	null
CRCGN015_MCF10A.TP53.M_24H:I03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30127
abnormality of bone marrow cell morphology	GWASdb SNP-Phenotype Associations	1.0	0.217137
duodenum	HPA Tissue Protein Expression Profiles	1.0	0.966054
KPNSI9S	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92896
GSE94814_2_v_3_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
circulating	GeneRIF Biological Term Annotations	1.0	null
SOX9-26525672-CHIP-SEQ-HEART-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MIEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89397
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22602
CFPAC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5558
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ICC8	DepMap CRISPR Gene Dependency	1.0	2.6952
Myoclonic epilepsy of Lafora	Reactome Pathways 2014	1.0	null
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
EIF3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23091
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DMS273	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.6794
ADISSP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57564
Defective CHST6 causes MCDC1	Reactome Pathways 2014	1.0	null
prostate	GTEx Tissue Gene Expression Profiles	1.0	0.925761
KMS21BM	CCLE Cell Line Gene CNV Profiles	1.0	2.04751
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7918-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SALL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82052
HELA	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.905229
Ventral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00216
BRD-K96778609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55207
BRD-K82224868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65966
WDR54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3319
PMC11732233-mmc1.pdf-118-ZBTB17_ZBTB17	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.939392
FXYD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98208
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
TUBB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17893
BRD-K66643401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30514
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.082718
NCIH226	DepMap CRISPR Gene Dependency	1.0	2.40352
BRD-K38692266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13019
IZ in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.979205
ERH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11025
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ITGB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79068
BRD-K48900723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00123
Perturb_12158_KD_LIN28A1_SRP061243	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.7644
PMC9630632-Table1.XLSX-diff_exp_genes-Group_2_vs_3_AND_Group_1_vs_3_NOT_Group_1_vs_2_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45959
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KW-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PUF60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20379
BRD-K74512976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02749
inferior occipital gyrus, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.996962
HMGCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34028
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TRMT61B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06346
pyramidal layer of S	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26407
bromopride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90819
BECKER	DepMap CRISPR Gene Dependency	1.0	8.13199
BRD-K16604405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23228
C19orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05957
Prelimbic area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.72937
Gustatory areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79892
ABHD14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49069
BRD-K64221857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44325
SRSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45751
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6362
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PCGF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03756
BRD-K66559139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75538
BRD-K50345393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6489
PFSK-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.25426
C4orf46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47123
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PFKP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91596
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20839
STX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44238
FAM169A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18502
MYOD1_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A39660642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08048
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65111
TP63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75945
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	67.6988
Alx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.9493
Brachial nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.75
BRD-K29420358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42193
BRD-K35616138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14026
Brain Lower Grade Glioma_LGG_TCGA-HT-7855-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NAMALWA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCC1954	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.64039
496100443_HIP_no dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.43529
Parataenial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78952
BRD-K79202867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1709
BRD-K30361950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5895
TARBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57594
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
KIF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05257
BRD-K81463178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17566
BRD-K26836050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35367
BRD-K22839533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83315
JMY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57921
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HUTU80	CCLE Cell Line Gene Expression Profiles	1.0	1.35309
BRD-K38558166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2948
LDL cholesterol levels in HIV infection	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.622185
layer 5 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53368
TRIFLUPERIDOL-2HCL	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.97725
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4763-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76578941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44611
Coronary Heart Disease	DisGeNET Gene-Disease Associations	1.0	null
language impairment	GWASdb SNP-Phenotype Associations	1.0	1.09488
CASKIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.69487
ventromedial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71481
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
TEAD1	JASPAR Predicted Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5483-01A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.808011
ZNF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7203
DDX60L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02813
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sarcoma_SARC_TCGA-DX-A6B9-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
BRD-A96536816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01327
GRK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58553
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K88679751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79866
EPHA4_drugactivation_229_GSE26523	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.30693
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of r4BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34549
SNU398	CCLE Cell Line Gene Expression Profiles	1.0	2.13796
BRD-K71274071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24619
AGPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52159
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.961607
BRD-K14909006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32623
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.43623
ATM_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
XPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30082
HMV-II	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Dmbx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.3773
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PACSIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76371
BRD-K69564473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55934
PHF21B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20959
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.865077
SUMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89857
HTR1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1147
Golgi lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.969
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
centromedian nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55095
IZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10947
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K56179613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57796
MYBL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.933
DUSP28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48641
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
r4 part of medial pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26551
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K04321001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81704
LARP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94568
BRD-K93101873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12802
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12358249-supplementary_table_s5_ioaf064.xlsx-DMRT1_-_vs_WT__4_months-Unnamed_1_DMRT1	Rummagene Transcription Factor Associations 2026	1.0	null
medial parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29772
H3K9me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45734531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21636
Endocytic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.828
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
culture condition	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.442194
Postcentral gyrus volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
ZNF772	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67023
NCI-H446	GDSC Cell Line Gene Expression Profiles	1.0	1.62585
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_15069_KD_Twist1_SRP150075	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	19.5229
CTAGE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61345
intermediate stratum of IC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15574
ZNF528	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74946
MS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE114992,GSE114993_9_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K23427500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14698
Perturb_8609_KD_Camta1_SRP048702	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.51698
Prostate adenocarcinoma_PRAD_TCGA-EJ-5527-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95672029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1256
OPM2	CCLE Cell Line Gene CNV Profiles	1.0	1.34735
GSE112714_2_v_0_ctnnb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
developmental disorder of mental health	GWASdb SNP-Disease Associations	1.0	0.302993
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36595
PMC3376834-emmm0004-0052-SD2.xlsx-NR2E3_Specific_1847-Unnamed_1_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6542-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GPC6	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16484
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lingual gyrus, left, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.928092
SU-DHL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
tyw3cryz	GeneRIF Biological Term Annotations	1.0	null
BRD-K96382853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43919
BRD-K96945047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74367
STT3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76733
Lung squamous cell carcinoma_LUSC_TCGA-85-7950-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K98189856	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04852
enzalutamide_homo sapiens_gpl570_gse44905	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
heparan sulfate proteoglycan biosynthetic process	GO Biological Process Annotations 2015	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18833
Invasive ductal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11956947-media-4.xlsx-C_GSEA_gene_sets-ATF3_Q6_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K01009153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03251
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Subiculum, dorsal part, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68091
ZNF275	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89632
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7034
Stomach	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.567443
ZNF345	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83371
Prelimbic area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18763
MPS IIIC - Sanfilippo syndrome C	Reactome Pathways 2014	1.0	null
NCLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32962
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5B-Up_H3K4me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Metapathway biotransformation Phase I and II	WikiPathways Pathways 2024	1.0	null
MAPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74249
NNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.27544
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.86866
BRD-K68408385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02985
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83324
MEOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4796
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92246187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17107
OTUD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20393
BRD-K61247793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43204
mantle zone of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06687
Glycosaminoglycan metabolism	Reactome Pathways 2024	1.0	null
CHL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TDRD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8689
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Dlx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.507
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Metabolism	Reactome Pathways 2014	1.0	null
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K72314068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25742
Substantia nigra, reticular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19747
AGRN	Pathway Commons Protein-Protein Interactions	1.0	null
NFYB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Piriform area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02341
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
MRPL37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57324
Exostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.506
Brain Lower Grade Glioma_LGG_TCGA-CS-6668-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE89636_2_v_0_glucagon_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:K04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02212
PRKAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64492
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE88819_1_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Folium-tuber vermis (VII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.88947
PTP4A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26814
laterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15288
[heparan sulfate]-glucosamine n-sulfotransferase activity	GO Molecular Function Annotations 2015	1.0	null
r3 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13156
GPATCH8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32921
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_DN3_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
GPI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96769
CTDNEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78223
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.747666
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5573-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7014-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE148494,GSE182513_1_v_0_hoxd13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SHPRH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01081
r3 part of medial pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16993
SOWAHC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02011
Nanog	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.3515
NCI-H2291	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K42663371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33704
RAD18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99636
MED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08695
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33702
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05248
MELJUSO	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20312
BRD-K08141534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03245
GSE207863_0_v_1_hdac5_human	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
uveal disease	GWASdb SNP-Disease Associations	1.0	0.454009
GSE214382,GSE214383_4_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H2BC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08968
stratum pyramidale of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.866698
Ebolavirus(EBOV)_3day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.80367
Noonan syndrome 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.551
BRD-K92613860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43894
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K90673570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02312
YWHAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78938
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39724
BRD-K22854578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40195
GSE113106_2_v_1_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAGOHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26018
BRD-K98519785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19765
ERI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.61342
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K16093370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10706
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.911
SLC36A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52012
GSE88819_1_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79693
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.06953
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32305
CRCGN015_MCF10A.TP53.M_24H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22435
Lateral entorhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.788
Mouse - Motor Cortex - Cluster - Vip+ C1ql1+ GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930845
ACACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27565
monastrol-311	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9572
NUDT21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80526
CCRF-CEM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RERFGC1B	CCLE Cell Line Gene Expression Profiles	-1.0	-2.02768
cuneus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.2794
BRD-K99277076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09249
MMUT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83024
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.49732
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.39481
CNN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95195
COLO684	DepMap CRISPR Gene Dependency	1.0	3.74363
Dorsal peduncular area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06516
BRD-K43496057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09759
ZNF296	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63157
GTF3C6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42295
lateral part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10738
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
CRCGN008_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.112
SYDE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02221
HT-1197	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:I15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02645
EGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16201
GSE162892_4_v_2_sox9_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_7808_KD_ACIN1_SRP075202	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
COA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55386
NCIH1385	CCLE Cell Line Gene Expression Profiles	1.0	2.40872
Reading disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
Perturb_14724_KO_Dicer_SRP082704	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-18.8239
LHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96605
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
LAPTM4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57302
BRD-K04819729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08688
raphe nuclei of medulla	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.908946
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.831032
L428	CCLE Cell Line Gene Expression Profiles	1.0	2.65493
BRD-K34747076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46089
VPS51	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11802
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.56281
superficial stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31868
septal nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.826661
BRD-K91282650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71527
SLC25A28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36692
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GID8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8878
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.068433
BRD-K92644013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16556
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE210101,GSE210114_8_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4363
sensory system disease	GWASdb SNP-Disease Associations	1.0	0.76125
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930845
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22268
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.57128
CPNE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.786
BRD-K07245666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26975
Anterior cingulate area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.24873
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.39524
CRCGN015_MCF10A_48H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20442
RAPGEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77738
BRD-K83786559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17545
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SFPQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89495
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TP73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.22411
OVCAR-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GFER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47354
BRD-K10317744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45107
GSE221327_5_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140997_10_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
HPCAL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01646
GSE140997_2_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K71561082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10686
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K13087600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35654
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.0406
REST	ENCODE Transcription Factor Targets	1.0	null
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16484
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN	ChEA Transcription Factor Targets	1.0	null
BRD-K13146924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24033
PMC11401502-mmc1.pdf-11-TSHZ3_TSHZ3	Rummagene Transcription Factor Associations 2026	1.0	null
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.09741
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2364
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7590-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8073
CIZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63529
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3701
BRD-K00046588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02676
Uterine Carcinosarcoma_UCS_TCGA-NG-A4VW-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBX2_KO_GDS4445_353_mouse_E11.5 XX embryonic gonads	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K11873306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08587
[heparan sulfate]-glucosamine N-sulfotransferase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K28764680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54172
external part of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82287
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MFM-223	GDSC Cell Line Gene Expression Profiles	-1.0	-1.56024
BRD-K11893906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41271
TMEM43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28682
SKNFI	DepMap CRISPR Gene Dependency	1.0	4.76786
TINAGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92033
BRD-K32782599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26016
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1703	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SULF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89262
Resistin levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.72218
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09462
CLCN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26183
Metapathway biotransformation(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
BRD-K28187112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08518
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15288
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.7058
BRD-K32947579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.61579
EIF2AK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80297
SALL4_01_98	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59287
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-555-ENSG00000164093_PITX2	Rummagene Transcription Factor Associations 2026	1.0	null
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.10916
BRD-K94114461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2726
RAB3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.43274
r9 portion of ambiguous motor nucleus (postmigratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11411
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
PLPPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97142
DMRTA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0375
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8519-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ovary	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.942555
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.85864
AXL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49863
NCOA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46834
H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC4454074-srep10806-s1.pdf-16-MYNN_MYNN	Rummagene Transcription Factor Associations 2026	1.0	null
Interanterodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54543
ZNF350	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01598
PrPC_KO_GDS4352_359_mouse_Developing hippocampus from adults (3-mo-old)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SPINDOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78715
TIPARP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45461
GSE218580_1_v_3_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
CRELD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15538
FOXP2	ENCODE Transcription Factor Targets	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
PPP1R13B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36815
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	57.4152
external part of AOV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.01214
SP140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46128
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
FBXW4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43182
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
C18orf25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.79254
BRD-K08650286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.245
CSNK2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46184
ZBTB48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83607
GSE88819_1_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K33906096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55137
lateral medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13204
GPC5	Pathway Commons Protein-Protein Interactions	1.0	null
Noonan syndrome 10	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.436
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6802
MOSMO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86251
Brain Lower Grade Glioma_LGG_TCGA-E1-5307-01A-01R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87107091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26415
CRCGN016_MCF10A.WT.HP_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4346
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K76415727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65203
SU-DHL-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.25426
REXO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70702
PHF23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38712
MPS I - Hurler syndrome	Reactome Pathways 2014	1.0	null
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.4979
GLYATL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60813
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-Netherlands-602-2009(H1N1)_7Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.59063
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.950118
ABCG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51013
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.19862
KIF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91861
hsa-miR-548n	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14268
MEL270	DepMap CRISPR Gene Dependency	1.0	2.71725
Primary somatosensory area, unassigned, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03952
BRD-K42960858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69184
NCI-N87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14516
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
Glycosaminoglycan synthesis in fibroblasts	WikiPathways Pathways 2024	1.0	null
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF260	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67873
r4 part of reticulotegmental nucleus, shell portion	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28893
Coronary Artery Disease	DisGeNET Gene-Disease Associations	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_KO_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
SNAP47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25281
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13122
USP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05165
PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
CDC37L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68259
BRD-K20497425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49844
abnormality of the kidney	GWASdb SNP-Phenotype Associations	1.0	0.638234
GSE155972_0_v_1_setdb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ASCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49338
DEAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09483
PI4K2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78769
SPIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72402
INO80C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.44033
RETREG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51505
HSFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88967
ZNF729	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93301
COX20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64307
RBM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71002
BRD-K83603369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81789
BRD-K24246830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5466
BRD-K97487406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46011
ZNF518B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66288
AMO-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
resistin	GeneRIF Biological Term Annotations	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3934
BRD-K10191318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02345
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3809
BRD-K32191695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53644
HBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54714
Brain_CT2_Inh L5-6 SST PAWR	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
SJRH30	CCLE Cell Line Gene CNV Profiles	1.0	1.42143
ALAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.01487
BRD-K77965546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05327
candidate	GeneRIF Biological Term Annotations	1.0	null
transferase activity	GO Molecular Function Annotations 2015	1.0	null
NCIH1573	DepMap CRISPR Gene Dependency	1.0	2.94369
PHF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97412
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CHAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44451
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
proteoglycan biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PZ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NSUN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90969
HT55	DepMap CRISPR Gene Dependency	1.0	2.44609
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28602
Taenia tecta, dorsal part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46904
Lymphoma_burkitts(Daudi)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.03794
RMUGS	DepMap CRISPR Gene Dependency	1.0	4.74897
BRD-K62148271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63486
GSE229102_1_v_0_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LTBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38235
CADO-ES1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EXOSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90244
TNFSF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69167
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.289
navicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74904
inner CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08354
pontine reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.11103
SCLC-21H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.895599
cellular process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K89632963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19407
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Anterior olfactory nucleus, external part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.11081
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
TPRX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42388
GTEx Nerve 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	1.0	4.02611
Brain Lower Grade Glioma_LGG_TCGA-TM-A7CA-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184902_4_v_1_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain_CT2_Splat 360	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
CBFA2T3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58171
BT483	CCLE Cell Line Gene CNV Profiles	1.0	1.5107
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K89394474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31451
TBP	ENCODE Transcription Factor Targets	1.0	null
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.083828
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22822
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	GO Biological Process Annotations 2023	1.0	null
JUN-21703547-K562-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100573_HIP_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.46266
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
COX6B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97456
Pontine gray	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18716
Brain_CT2_Amex 405	HuBMAP ASCT+B Annotations	1.0	null
GSE142210_3_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF695	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49996
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.5099
BRD-K98953112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76186
RBBP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77804
D-283MED	GDSC Cell Line Gene Expression Profiles	-1.0	-1.97239
BRD-K90003650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65274
COQ10A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42607
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.64071
OLIG2	ChEA Transcription Factor Targets	1.0	null
ZNF99	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70835
CKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09829
WASHC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93155
BRD-K16919185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23985
NCI-H2110	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LRRC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67598
FZD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53015
TRAPPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99229
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.1389
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042108
BRD-K73290515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52116
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2204
H2BC21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77795
NCI-H1573	COSMIC Cell Line Gene Mutation Profiles	1.0	null
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60119
HCC-38 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
LI7	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2322
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K18452866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26149
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.1604
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78528
BRD-K62288678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18067
layer 1 of VPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26442
Declive (VI), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77636
GSE135030_8_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH209	CCLE Cell Line Gene Expression Profiles	1.0	1.45534
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10697
hsa-miR-526b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
HCC38	CCLE Cell Line Gene CNV Profiles	-1.0	-2.03273
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053189
NCI-H748	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JT-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32422
heparan sulfate proteoglycan metabolic process	GO Biological Process Annotations 2015	1.0	null
MAPK8IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01134
COV644	CCLE Cell Line Gene CNV Profiles	-1.0	-2.05911
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
Primary somatosensory area, nose, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03848
SF767	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54013
GSE139239_1_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87754
SETDB1	ENCODE Transcription Factor Targets	1.0	null
SPZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2995
Medial preoptic nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09965
BRD-K44494409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55076
BRD-K78311779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65926
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4811-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CAMK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57927
GCSH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53504
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.839071
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
near	GeneRIF Biological Term Annotations	1.0	null
PMC12616242-can-24-3452_supplementary_table_s4_suppst4.xlsx-EWSR1-FLI1-KDM6B_genes-Genes_associated_to_EWSR1_FLI1-KDM6B_peaks_in_A-673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE109565_12_v_4_glyphosate_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCDC137	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14649
P53-22387025-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
OVK18	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48263
BRD-K12862541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08718
UBA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72691
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.1824
BRD-K31778201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84913
GSE93674_2_v_3_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HMCES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89816
J82	DepMap CRISPR Gene Dependency	1.0	3.02829
BRD-K89338967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13611
AK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48473
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.895599
MCC26	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HuCCT1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.10158
Perturb_8633_KO_Sh3gl1/Sh3gl2_SRP082219	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.80602
NLGN4X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90528
PK1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61657
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
ZFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57356
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5681-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALG13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06482
BRD-K88485670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1735
ARMCX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06714
SNU-423	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.865077
heparan sulfate proteoglycan biosynthetic process	GO Biological Process Annotations 2023	1.0	null
LOUNH91	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39133
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3655
SNG-M	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LEAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60427
SEC23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34995
intermediate stratum of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22851
organic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC10679662-mmc2.xlsx-NC-D5-ZEB2-siRNA-Downregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31921933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08969
NCIH650	CCLE Cell Line Gene Expression Profiles	-1.0	-2.45855
GSE86507,GSE86509_7_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
163 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.591
HOXD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51122
PIAS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46308
Adrenocortical carcinoma_ACC_TCGA-PK-A5H9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051626
GSE248045,GSE248046_4_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Subiculum, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.63072
BRD-K38273665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53174
Taenia tecta, ventral part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82239
Olig2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8727
RASGRP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0951
golgi apparatus part	GO Cellular Component Annotations 2015	1.0	null
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE88819_7_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Simple lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35213
KDM5A	ENCODE Transcription Factor Targets	1.0	null
ZBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94666
BRD-A77164655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23865
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MPS II - Hunter syndrome	Reactome Pathways 2014	1.0	null
ZNF708	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4005
PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-214-AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NR2E3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13236
Sarcoma_SARC_TCGA-DX-A8BU-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24554824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31453
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930845
BRD-K12986105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81163
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.044929
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.1881
MRC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47498
macular degeneration	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
PMC6485480__F1	PFOCR Pathway Figure Associations 2023	1.0	null
SW684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83V-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
S100A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37387
NPPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09419
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.79655
BRD-K45537529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85942
PPP1R26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30015
abnormal respiratory system morphology	GWASdb SNP-Phenotype Associations	1.0	0.132234
Pterygium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.828
PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
CYTH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25375
BRD-K29379705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50435
mantle zone of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11518
Posterior complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58326
posteromedial visual area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05266
ERBB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02293
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WU-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF367	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55612
P300-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_11_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31602464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17866
GSE162276_4_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174701_5_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:M12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22733
BRD-K71452126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21664
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.232599
496100319_HIP_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.78076
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.768
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
TE9	CCLE Cell Line Gene CNV Profiles	1.0	2.04159
GSE114992,GSE114993_1_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
B2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41528
PPP2R2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20969
BRD-K81372179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16411
CYP27C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77375
BRD-K21483524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18
TRAK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05318
CTTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33109
OTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12773
Lung squamous cell carcinoma_LUSC_TCGA-34-5231-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.830396
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.983774
HS2ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69716
BRD-K21443215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82051
Lung adenocarcinoma_LUAD_TCGA-44-7667-01A-31R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K35724671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4306
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.297
ZNF257	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97295
AOB, internal plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22164
retinal disease	GWASdb SNP-Disease Associations	1.0	0.739348
Perturb_17282_KO_Hsf5_SRP345601	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
LLGL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36294
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6165
ECC2	DepMap CRISPR Gene Dependency	1.0	2.32089
TJAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14099
Mesothelioma_MESO_TCGA-TS-A7P8-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Huntington's Disease_Lymphocyte_GSE8762	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.60115
BRD-K09975619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04228
Alx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.5117
ACAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36519
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	Reactome Pathways 2014	1.0	null
BRD-A57174914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00973
RASD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37348
MRPL49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16078
CUL4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72991
LS411N	DepMap CRISPR Gene Dependency	1.0	2.09793
arcuate nucleus of medulla, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.79881
FIGLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63014
interanterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.59067
BRD-K99198579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1411
Anterior cingulate area, dorsal part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12834
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5264-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1069
PMC12616242-can-24-3452_supplementary_table_s4_suppst4.xlsx-EWSR1FLI-KDM6A_genes-Genes_associated_to_EWSR1_FLI1-KDM6A_peaks_in_A-673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
ZDHHC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48274
ATP6V0E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05763
SMAD4-21799915-A2780-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NR4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07529
TENM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21929
BRD-K11516621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21691
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.865077
GSE140997_10_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
FAM199X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16893
ERI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60162
NFKBIZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55685
MRFAP1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.18813
superficial stratum of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26551
BRD-K84792324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07194
BRD-K63058274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54398
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.1288
artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.044989
PMC7888619-pgen.1009309.s032.xlsx-S9_Table-S9_Table_Predicted_target_genes_of_POU3F2_POU3F2	Rummagene Transcription Factor Associations 2026	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
BRD-A34842997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11519
ventrolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06306
Glycosaminoglycan metabolism	Reactome Pathways 2014	1.0	null
GSE203308_4_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HTR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9434
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.466
ZNF585B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69488
CTNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72746
GPAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43902
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SH3BGRL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52884
PMC11250262-41588_2024_1798_MOESM4_ESM.xlsx-ST18_665_top_menarche_genes-gene_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
Ventral pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21492
abnormality of the retina	GWASdb SNP-Phenotype Associations	1.0	0.638234
red nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.868393
significant	GeneRIF Biological Term Annotations	1.0	null
C1orf159	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70926
LIG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29009
BRD-K75041866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0413
CAL29	DepMap CRISPR Gene Dependency	1.0	2.22104
POU6F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2838
BRD-K63212062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21962
GAL3ST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38584
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.8643
BRD-A99445203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28804
CACHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8053
PRM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91129
BRD-K98016463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73481
TP53	ChEA Transcription Factor Targets	1.0	null
SIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40425
BRD-K10398797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18636
mantle zone of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10772
EGR2_01_242	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60154
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE214382,GSE214383_5_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72012
CRCGN017_MCF10A.TP53.M_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27875
MUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63333
MAFG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74579
PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4B-Up_Nanog_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CCDC85B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0969
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.01464
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.17457
specific developmental disorder	GWASdb SNP-Disease Associations	1.0	0.346175
Declive (VI)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.92577
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.843274
pancreas	HPA Tissue Protein Expression Profiles	1.0	1.99009
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
ETFBKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87905
BRD-K70875838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26861
GSE152699,GSE152723_3_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02956
CRCGN015_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33535
inner SZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02421
STK16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46622
ES8	GDSC Cell Line Gene Expression Profiles	1.0	1.51614
BRD-K44932450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18471
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1196
stratum pyramidale of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19752
ACSM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34649
BRD-K59191599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03065
EW-11	GDSC Cell Line Gene Expression Profiles	1.0	1.75119
BRD-K69791255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55991
layer 3 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.48703
intermediate stratum of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0131
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Distal-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_13742_KO_Nfib_SRP096738	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.64334
FERD3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03761
BRD-K20560768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.498
Kidney renal clear cell carcinoma_KIRC_TCGA-AS-3777-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K73095160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05081
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.901185
BRD-K33939287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07159
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MED14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73641
GSE145323,GSE145324_1_v_0_rfx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MFNG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64608
Perturb_12227_KD_TARBP2_SRP197041	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.3486
layer 6b of PaS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12444
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
caudal prosubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.82152
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.081
Lung adenocarcinoma_LUAD_TCGA-55-5899-01A-11R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MM253	DepMap CRISPR Gene Dependency	1.0	2.28512
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07674
Pyramus (VIII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41186
FBXO11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30108
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVCAR8	CCLE Cell Line Gene CNV Profiles	1.0	1.36992
superficial stratum of LPrP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1835
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.096824
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
MPS VI - Maroteaux-Lamy syndrome	Reactome Pathways 2014	1.0	null
CLDN34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16156
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A84G-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79438478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01611
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Long-projecting GABAergic cell_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
Subiculum, dorsal part, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46703
TMEM200A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52091
posteromedial visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32351
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Reactome Pathways 2014	1.0	null
GSE136238_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K50704115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14463
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
chr4_115285011_C_CAT_b38	GTEx eQTL 2025	1.0	2.1268
abnormality of the posterior segment of the eye	GWASdb SNP-Phenotype Associations	1.0	0.200056
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21717
LK-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
bounding membrane of organelle	GO Cellular Component Annotations 2015	1.0	null
ZBTB37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.9759
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
facial motor nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.939147
SW1990	CCLE Cell Line Gene Expression Profiles	-1.0	-1.98503
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K01296372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13755
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
Ventral posteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51669
IGDCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52382
STARD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29109
abnormality of the anterior segment of the eye	GWASdb SNP-Phenotype Associations	1.0	0.205506
BRD-K23836639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79474
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
SKES1	CCLE Cell Line Gene Expression Profiles	1.0	1.67191
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.947229
REST_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32753
PAX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5653
inner CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20147
proteoglycan metabolic process	GO Biological Process Annotations 2015	1.0	null
Taenia tecta, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.53681
GPC4	Pathway Commons Protein-Protein Interactions	1.0	null
Defective SLC26A2 causes chondrodysplasias	Reactome Pathways 2014	1.0	null
NUDCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17696
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K99516890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70457
KCTD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12814
KIT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97601
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE219195_4_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Breast carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
NKM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_1076_KO_Mr1_ERP107271	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.96382
CLN8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61648
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A1OB-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Speech disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
496100622_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.16693
Diseases associated with glycosaminoglycan metabolism	Reactome Pathways 2014	1.0	null
CUX1	ChEA Transcription Factor Targets	1.0	null
LRP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90208
BRD-K25773863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12687
Colonic adenoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.618
RT112	DepMap CRISPR Gene Dependency	1.0	9.05538
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA1-25552417-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049978
abnormality of the face	GWASdb SNP-Phenotype Associations	1.0	0.116413
19658189-TableS4	GeneSigDB Published Gene Signatures	1.0	null
SKNMC	CCLE Cell Line Gene Expression Profiles	1.0	2.01833
SLC38A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96081
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86151
UBR5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15938
BRD-K12612468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98244
glycan structures biosynthesis 1	KEGG Pathways	1.0	null
HUO-3N1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
substance-related disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.412405
BAG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54388
ZMIZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86025
MRPS14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06378
Conjunctival epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
P-loop containing nucleoside triphosphate hydrolase	InterPro Predicted Protein Domain Annotations	1.0	null
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain_CT2_Inh L5-6 SST PAWR	HuBMAP ASCT+B Annotations	1.0	null
DKK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60719
r8 portion of ambiguous motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16883
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WO-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.804478
Arid5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.2536
H9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.061
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49203165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24813
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.955717
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
496100521_HIP_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.06053
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7072-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59189
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87754
membrane part	GO Cellular Component Annotations 2015	1.0	null
MAPK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4306
BRD-K01995700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96679
Learning disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
Accessory olfactory bulb, mitral layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02506
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18285
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
Supplemental somatosensory area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16711
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.31641
Mouse - Motor Cortex - Cross-Species Cluster - Lamp5+ GABAergic neuron_1	HuBMAP Azimuth Cell Type Annotations	1.0	null
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.15433
HCC1395	CCLE Cell Line Gene CNV Profiles	1.0	2.01079
BRD-A96308662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64412
Sarcoma_SARC_TCGA-DX-A48K-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.054587
rosiglitazone_mus musculus_gpl7202_gse19896	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26589
GPRASP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60899
18400362-Figure4a	GeneSigDB Published Gene Signatures	1.0	null
FAM89B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7983
Medial amygdalar nucleus, posterodorsal part, sublayer a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76717
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
superficial stratum of r8Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.167
LCMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57526
BRD-K17061569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48155
NCI-H2722	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.982942
hsa-miR-3188	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K14812927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21763
Lobule III, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13941
molecular_function	GO Molecular Function Annotations 2015	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K43306617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13277
NCI-H209	GDSC Cell Line Gene Expression Profiles	1.0	1.78264
abnormality of cells of the erythroid lineage	GWASdb SNP-Phenotype Associations	1.0	0.265282
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.50594
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.5895
BRD-K71253424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04538
alzheimer disease	GWASdb SNP-Phenotype Associations	1.0	0.48718
PMC3419980-leu201249x4.xls-H3K9Ac-RUNX1ETO_peaks_2fold-All_gene_regions_overlapping_with_RUNX1-ETO_peaks_changing_histone_acetylation_more_than_2-fold_after_knock-down_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K76664579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.54869
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
RASAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4037
SUN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00193
posteromedial visual area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70883
Sarcoma_SARC_TCGA-SG-A6Z7-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAP3K1_knockout_245_GSE39240	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.26733
BRD-K14307099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98266
Brain Lower Grade Glioma_LGG_TCGA-E1-5319-01A-01R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Anterior olfactory nucleus, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75116
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04837
Spondyloepiphyseal dysplasia with congenital joint dislocations	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
FAM135A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5834
NCCIT cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.996
Ventral posterior complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31459
glycosaminoglycan biosynthetic process	GO Biological Process Annotations 2015	1.0	null
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
icSARA deltaORF6_7Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.75288
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
medial part of r4B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15242
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.57373
TRMT61A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79567
CAL78	CCLE Cell Line Gene CNV Profiles	1.0	2.3357
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0218
pontine nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.13705
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7227
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.88855
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.855443
GPC2	Pathway Commons Protein-Protein Interactions	1.0	null
ventral nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59208
dorsal cortical nucleus of inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44587
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95578456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7611
BRD-K24308170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55382
golgi apparatus	LOCATE Predicted Protein Localization Annotations	1.0	null
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8851
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
LRPPRC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98526
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN2_n_EN2	Rummagene Transcription Factor Associations 2026	1.0	null
layer 2 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.86233
BICR22	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46587
substance dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.581217
HNRNPAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35582
HSPG2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K39979171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97164
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
IFI6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23465
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.1939
PTK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38169
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.910322
OE33	DepMap CRISPR Gene Dependency	1.0	2.14327
TEAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0405
eye disease	GWASdb SNP-Disease Associations	1.0	0.208437
BRD-K51050934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20725
myclobutanil	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98996
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LN-18	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30574
PMC5325343-oncotarget-07-63003-s002.xlsx-Supplementary_Table_1-Supplementary_Table_1_Genes_upregulated_by_EWS-FLI1_in_the_Gordon_et_al_data_set_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TFEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5687
Lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43584
TMEM223	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76313
SORBS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87988
metabolic process	GO Biological Process Annotations 2015	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
ZNF521	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81436
BRD-K11504463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09603
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.369
Inferior colliculus, dorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5175
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NAGPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1724
BRD-K82460510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4162
Defective PAPSS2 causes SEMD-PA	Reactome Pathways 2014	1.0	null
BRD-K70712582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63254
ZNF160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13897
reading disorder	GWASdb SNP-Disease Associations	1.0	1.25021
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A89947015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16773
PMC8044433-mmc4.xlsx-Sheet1-Acute_LPS_Microglia_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ELK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42702
CRCGN010_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01357
ST3GAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72185
alcoholism	GAD Gene-Disease Associations	1.0	null
STOML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92138
DAOY	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44128
BRD-K66641352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17865
BIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42502
BRD-K88369626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51826
Anterior cingulate area, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.77112
BRD-K13564884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05871
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22914
IRF3	ENCODE Transcription Factor Targets	1.0	null
TOR1AIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93333
OBI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86904
BRD-K28269391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21637
Enamel epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.833
HACD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83425
BRD-K83466873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.86462
DHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73829
GSE210101,GSE210114_0_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-EF-5830-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56708236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12691
19286929-SuppTable2q	GeneSigDB Published Gene Signatures	1.0	null
ZNF711	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91274
GSE188570,GSE188571_3_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1395	COSMIC Cell Line Gene Mutation Profiles	1.0	null
substance-related disorder	GWASdb SNP-Disease Associations	1.0	0.177354
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13061_KD_Bcl10_SRP310454	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.4553
GSE169205_3_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225869_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Dlx5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.1707
Folium-tuber vermis (VII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.86944
mantle zone of IC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03844
ventral posterolateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26462
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23326
Inferior colliculus, central nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11659
suppressor	GeneRIF Biological Term Annotations	1.0	null
Retrochiasmatic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13992
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38748
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9852
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K51858914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67183
Type IC spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
JAK2_knockdown_192_GSE54645	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.68404
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.225
POLR2A	ENCODE Transcription Factor Targets	1.0	null
r3 part of reticulotegmental nucleus, shell portion	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25901
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOXA1_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14913
variants	GeneRIF Biological Term Annotations	1.0	null
YPEL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89388
SF539	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.5862
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
type ii diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.458791
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7414-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11373733-ABR-13-34_Suppl1.pdf-70-ZNF248_ZNF248	Rummagene Transcription Factor Associations 2026	1.0	null
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.76589
Tegmental reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3297
intermediate stratum of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08945
LN-18	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9173
SW872	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ARHGEF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30083
SDHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16979
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
abnormality of the mouth	GWASdb SNP-Phenotype Associations	1.0	0.153664
Mdr2_KO_GDS1990_286_mouse_Livers of 12 month old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MPS IIID - Sanfilippo syndrome D	Reactome Pathways 2014	1.0	null
PMC12494973-41467_2025_63880_MOESM1_ESM.pdf-132-TEF_TEF	Rummagene Transcription Factor Associations 2026	1.0	null
SKMEL5	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71757
KDR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75817
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.54
transient Purkinje cell clusters	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49144
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.865077
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.5
FGD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35666
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.0728
CTPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37441
BRD-K51525251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61959
Mediodorsal nucleus of the thalamus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07322
LATS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05902
Perturb_15875_KO_Atoh1_SRP002802	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.78084
Language disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.9654
BRD-A06837695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16843
IGROV1	DepMap CRISPR Gene Dependency	1.0	5.23597
organelle part	GO Cellular Component Annotations 2015	1.0	null
layer 2 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.18642
H3K9ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
heparan sulfate sulfotransferase activity	GO Molecular Function Annotations 2025	1.0	null
COMMD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68248
BRD-K18428988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1767
496100384_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.7525
ZDHHC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5661
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05333
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01228
LB771HNC	DepMap CRISPR Gene Dependency	1.0	2.70344
D283MED	DepMap CRISPR Gene Dependency	1.0	3.44835
FLT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12507
Taenia tecta, dorsal part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69523
600MPE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.3263
KCNG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58748
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.0189
kidney	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.944378
BE-13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.865077
anterior olfactory area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83375
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-genes_with_only_SALL4_peaks-Protein-coding_genes_that_show_only_CUT_RUN_peaks_with_2_SALL4_antibodies_and_no_other_antibodies_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE133087_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PHF21A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82669
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2546
496100392_HIP_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.53324
BRD-K25974714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05996
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.135
KPNYN	DepMap CRISPR Gene Dependency	1.0	2.30366
GPATCH11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86556
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K12918607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42618
CCDC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17062
CD79B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90974
External cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20514
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.62292
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4431
BRD-K26051127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28432
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6044
abnormal eye morphology	GWASdb SNP-Phenotype Associations	1.0	0.202773
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15796
MFE280	DepMap CRISPR Gene Dependency	1.0	6.93325
dorsal raphe nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.853409
outer CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00644
Z chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.036
SKNO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57314
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87754
GSE179138_4_v_1_lama4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8624
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.548
DHX57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67382
Perturb_542_OE_EWSFLI_SRP168621	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	12.603
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K88200581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96105
Heparan sulfate/heparin (HS-GAG) metabolism	Reactome Pathways 2014	1.0	null
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ventromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01022
BRD-K44955380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07054
ESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0772
GSE145915_5_v_4_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF582	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16346
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4423
BRD-K60337516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17865
SLC25A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67744
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.936138
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Perturb_4139_KO_Rai1_SRP074487	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.78356
anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03571
BRD-K98444789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14721
SMAD4	ChEA Transcription Factor Targets	1.0	null
ZCCHC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12693
CDK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79561
Cataract 3 multiple types	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.669
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2107
SHP77	CCLE Cell Line Gene Expression Profiles	1.0	1.42527
genetic	GeneRIF Biological Term Annotations	1.0	null
BRD-K82729465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04368
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Stratum lucidum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
LIME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68582
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-6690-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE225869_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K52582315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30555
ASS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77886
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.09741
r4 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34652
abnormality of taste sensation	GWASdb SNP-Phenotype Associations	1.0	0.659244
rectum	HPA Tissue Protein Expression Profiles	1.0	0.966054
DACH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25179
ZNF254	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50485
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.8643
GSPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98969
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
DBTRG-05MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
dorsomedial part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07977
Electrocardiogram morphology (amplitude at temporal datapoints)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.999469
Human - Motor Cortex - Cluster - SST+ CLIC6+ Layer 1-2 GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
P3H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45626
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7532
Taenia tecta, dorsal part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.5391
H3K4me3_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE199541_2_v_4_mbd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95035301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17348
Kidney Chromophobe_KICH_TCGA-KM-8639-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TLK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98719
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6909-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCIMY5	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47363
abnormality of the iris	GWASdb SNP-Phenotype Associations	1.0	0.690584
JURKAT	DepMap CRISPR Gene Dependency	1.0	2.02491
Piriform area, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19298
EIF5A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82193
PK59	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35176
BRD-K72646819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26817
BRD-K88447092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.70185
Mouse - Motor Cortex - Cross-Species Cluster - Sst+ Chodl+ GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
BRD-K82658511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06002
BRD-K50417536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07289
Perturb_4473_KO_Prdm12_SRP304476	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.97052
Perturb_5711_KO_Dgcr8_SRP043436	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.74433
MYT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48346
language disorder	GWASdb SNP-Disease Associations	1.0	1.25021
IFITM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6632
BRD-K92167240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09309
DROSHA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90776
ACAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72127
ZFP36L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55757
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.894106
CHCHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90448
abnormality of the respiratory system	GWASdb SNP-Phenotype Associations	1.0	0.104514
ARAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26561
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073181
SDC3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AH-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MLKL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83276
KYSE450	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68193
C8G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28151
BRD-K09454191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40393
Wnt signalosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.513
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6062
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.159786
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6871-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIRT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73302
PCBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22196
KIAA2013	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22077
IGFBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82788
dementia	GWASdb SNP-Disease Associations	1.0	0.34469
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21478
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.828642
vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042562
UBA52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03659
NMD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54015
MAP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92043
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31535
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Outer dynein arm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.722
GSE142232,GSE142234_0_v_2_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Medial pretectal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02309
Paracentral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21291
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8144624-41598_2021_90212_MOESM2_ESM.xlsx-6_hrs_ps_LPS-merged_Gene_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
stratum pyramidale of rostral CA3	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.824063
sulfotransferase activity	GO Molecular Function Annotations 2015	1.0	null
GSE92614_1_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.159462
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6221-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
BHT-101	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.44521
HDAC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86667
WIPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23241
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
H357	DepMap CRISPR Gene Dependency	1.0	2.60568
r9 part of the lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65399
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K64317863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34237
Anterior olfactory nucleus, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.30251
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6125
ABHD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5093
BRD-K89324382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11381
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074228
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
mantle zone of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15278
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.53234
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.066443
BRD-K71499752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62643
ONECUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38701
USP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09168
BRD-K88645787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15365
NCIH1092	CCLE Cell Line Gene Expression Profiles	1.0	1.50591
SLC39A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34239
ZNF276	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92773
IMR-5	GDSC Cell Line Gene Expression Profiles	-1.0	-2.33854
H3K9me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Language Development Disorders	HuGE Navigator Gene-Phenotype Associations	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Glycogen storage disease II	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
PAX5_OE_GDS4978_548_human_L428-PAX5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
E2F1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
iris disease	GWASdb SNP-Disease Associations	1.0	0.794247
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-7523-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF329	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25489
MOGGUVW	DepMap CRISPR Gene Dependency	1.0	2.38353
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6921
CRCGN017_MCF10A.WT.HP_24H:F10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17585
BRD-K75037209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30473
BRD-K69466030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93514
GSE217101_0_v_1_mcph1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PITRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76867
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_-2-1280_genes_are_more_than_four-fold_downregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92803674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66653
TARDBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60271
GSE191105_2_v_4_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRBN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40974
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2021
retinal degeneration	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
BRD-K34262858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5462
ZNF669	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50924
BRD-A90249268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04079
PSMD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11357
NCI-H1836	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K90356496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.52676
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
dorsal spiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19373
NCIH1755	DepMap CRISPR Gene Dependency	1.0	2.09917
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	1.0	2.53367
BRD-K87558616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19134
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HT-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K34640380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14907
carbohydrate derivative biosynthetic process	GO Biological Process Annotations 2015	1.0	null
ZNF81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19508
NCIH2171	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3514
TRAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19229
CBLL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55711
SLC26A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65616
Lobule III, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0512
posterior (ventral) nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.08453
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.0617
RAPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89707
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.174118
BRD-K92365616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49552
PMC10528072-NIHMS1928302-supplement-5.xlsx-ASCL1-target_genes-ABAT_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8144624-41598_2021_90212_MOESM2_ESM.xlsx-3_hrs_ps_LPS-merged_Gene_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TOP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4309
FDXR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78136
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2814
Autism spectrum disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
BRD-K60107240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4245
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.6323
Restless legs syndrome	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.911
CBY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80036
BRD-K50943704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11329
CRCGN015_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48911
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.196
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
JEKO-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K69960043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43302
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K87146261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14356
TAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56067
PXMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14397
BRD-K65888165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37144
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1242
BRD-A68797623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24871
CRCGN014_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02445
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25598
BRD-K61555339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70871
central nervous system disease	GWASdb SNP-Disease Associations	1.0	0.087505
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162892_4_v_2_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VDR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27576
butyrylcholine-cl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.9003
RMGI	CCLE Cell Line Gene CNV Profiles	1.0	1.55905
Heparan sulfate/heparin (HS-GAG) metabolism	Reactome Pathways 2024	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RPRML	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50076
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
superficial stratum of r3BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16993
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GDAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66327
COR-L303	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LMBR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28878
BRD-K55505527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75844
PATZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60777
ATG9A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35346
Simple lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.62931
Belzutifan_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0145788
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RO60	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66146
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.881828
Brain Lower Grade Glioma_LGG_TCGA-HT-8109-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CFL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35467
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.86244
Nucleus of the solitary tract, commissural part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0803
L-428	GDSC Cell Line Gene Expression Profiles	1.0	3.59634
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30574
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.845215
Idiopathic fibrosing alveolitis_Lung Tissue_GSE21369	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.85683
BRD-K88856685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58418
CHL1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48062
neurodevelopmental abnormality	GWASdb SNP-Phenotype Associations	1.0	1.09488
TNFRSF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28211
Taenia tecta, ventral part, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9529
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-8358-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
LIVF001-015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07839
abnormal glucose homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.302106
KYSE-150	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K57184082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41725
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.72979
GLB1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88995
Brain_CT2_Inh L1 SST DEFB108B	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
COIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22744
intermediate stratum of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04822
ASB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43285
HMC18	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58438
KNS-62	COSMIC Cell Line Gene Mutation Profiles	1.0	null
nasopharynx	HPA Tissue Protein Expression Profiles	1.0	0.966054
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02947
showed	GeneRIF Biological Term Annotations	1.0	null
RARB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25133
RAP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7047
BRD-K04429417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41787
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9557
SCAMP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84098
Alcoholism	HuGE Navigator Gene-Phenotype Associations	1.0	null
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_6_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.75647
DLL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11717
PMC10771438-41598_2023_51082_MOESM1_ESM.xlsx-Day21-Supplementary_Dataset_1_List_of_genes_differentially_expressed_during_NS_PC_differentiation_between_ROR2_KD_cells_and_control_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.065143
pontine nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.17753
PMC4815041-NIHMS715090-supplement-Supplementary_Table_10.xlsx-CCF_DP_clustering-Hugo_Symbol_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54881917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44804
DUXB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93697
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.870601
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3HZ-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
eye disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
TM31	CCLE Cell Line Gene CNV Profiles	1.0	2.59998
subiculum, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.32577
Brain_CT2_Amex 405	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
DPH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59607
abnormal colon morphology	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Liver	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K75145803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17462
GSE120200,GSE127269_1_v_2_asxl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
neurodegenerative disease	GWASdb SNP-Disease Associations	1.0	0.249756
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.993302
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
MYOD1_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dyslexia	HuGE Navigator Gene-Phenotype Associations	1.0	null
TP53-18474530-U2OS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Brain_CT2_Splat 360	HuBMAP ASCT+B Annotations	1.0	null
ARRDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.446
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
DYRK1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67181
BRD-K41031262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38311
BRD-K30865566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39658
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9604
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.974496
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1751
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K43909206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12861
GSE88819_6_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ARGLU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17048
METTL9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.162
MRPS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4796
GSE237984_1_v_0_magi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058551
BRD-K88087295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23041
UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K9me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7402-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67604
BRD-K78944047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41469
DNER	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91358
Defective CHST3 causes SEDCJD	Reactome Pathways 2014	1.0	null
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5293
AR	ChEA Transcription Factor Targets	1.0	null
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	1.0	2.82901
MMP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10742
NLRX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41186
496100604_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.08443
sensory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
single-organism process	GO Biological Process Annotations 2015	1.0	null
OTUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46241
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87754
496100303_HIP_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.67068
TMEM63B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6275
pyramidal layer of IG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.40971
EW8	CCLE Cell Line Gene Expression Profiles	1.0	2.25231
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AJUBA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21144
GSE181959_3_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OTX2_01_268	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.68949
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.055176
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-AAVH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Breast ductal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.072765
lateral parabrachial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.88602
PATU8902	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34068
Perturb_14661_KO_Insm1|Pax6_ERP127840	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Brain Lower Grade Glioma_LGG_TCGA-HT-7604-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.54229
SU-DHL-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.44603
BRD-A92357389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34474
BRD-K36241360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13958
Human - Motor Cortex - Cluster - SST+ PAWR+ Layer 5-6 GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TMEM126B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67292
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.22914
Human - Motor Cortex - Cluster - PVALB+ CDK20+ Layer 1-2 GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
Ventral anterior-lateral complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05586
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE140997_2_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
glycoprotein metabolic process	GO Biological Process Annotations 2015	1.0	null
superficial stratum of AOV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.18642
EBF1	ENCODE Transcription Factor Targets	1.0	null
MPP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20856
imatinib_homo sapiens_gpl96_gds3044	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RBBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.21282
CLOCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95777
probucol_mus musculus_gpl9525_gds3618	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K94692455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5213
SNU878	CCLE Cell Line Gene Expression Profiles	1.0	1.77478
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8505
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K69536411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32994
SP110	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37212
BRD-K71502099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00383
colonic epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.750405
PEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43654
MCAD_KO_GDS4546_422_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42303
SNU423	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71965
BRD-A60487173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4394
RAD54B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39053
CRCGN015_MCF10A.WT.HP_24H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39551
CRCGN015_MCF10A.TP53.M_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09115
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.996863
CRCGN017_MCF10A.WT.HP_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9477
NUPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57271
BRD-A32018906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28428
PPIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25457
GSE210870_0_v_1_snai1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PKNOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56328
Medial entorhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.758
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE142019,GSE142021_1_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRKRIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9559
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
induseum griseum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.40971
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.99982
CRCGN012_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55922
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
SEMA5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32533
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21717
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.971742
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_14494_KO_Igsf11_SRP320670	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.58241
Brain_CT2_Inh L5-6 SST KLHL1	HuBMAP ASCT+B Annotations	1.0	null
MPS IIIB - Sanfilippo syndrome B	Reactome Pathways 2014	1.0	null
ITPRIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59331
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.81169
anterior olfactory area, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.18734
organonitrogen compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053729
cardiovascular system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	1.25426
CEND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14428
CAPN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39215
GSE126345_4_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71792
LRRK2_mutant_32_GDS4400	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.14125
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.865077
deacetylase activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K26237438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01088
SRSF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95777
BRD-K52731672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33629
GPR160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.82315
PTPRCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33445
BRD-K65112040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15767
HS939-T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-106-PITX2_PITX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K80965028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01136
Postsubiculum, layer 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08135
Pyramus (VIII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32849
PMC6299095-41389_2018_108_MOESM4_ESM.xlsx-T47D-TRPS1_peak-gene_symbol_TRPS1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39406901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.489
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KRT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87305
BRD-K17285234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.26841
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
aminoglycan biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
OSBPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68622
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.908675
BRD-K45057266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97573
BRD-K12886565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90611
KLHDC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.32471
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Crx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4553
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMMR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26678
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A461-01A-41R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6407-01A-13R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.424
Anterior cingulate area, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48397
diabetes mellitus	GWASdb SNP-Phenotype Associations	1.0	0.638234
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TSPAN14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40616
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.9572
abnormal hemoglobin	GWASdb SNP-Phenotype Associations	1.0	0.638234
BRD-K79184750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45353
BRD-K04546974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02124
ETAA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51151
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.994517
DOK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96344
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WH-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77834935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79689
CALU6	CCLE Cell Line Gene Expression Profiles	1.0	1.62469
BRD-K47538257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01365
HOXD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05563
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02428
OSR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.514
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IJ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K03542527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18745
HEK 293T	BioGPS Cell Line Gene Expression Profiles	1.0	1.00979
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26632
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930845
SDC1	Pathway Commons Protein-Protein Interactions	1.0	null
PDXP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2125
Communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
Glycosaminoglycan biosynthesis - heparan sulfate / heparin	KEGG Pathways 2026	1.0	null
TE-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6400-01A-12R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCCSUP	CCLE Cell Line Gene Expression Profiles	-1.0	-2.9975
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K95192796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11535
BRD-K06392309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82026
YAP1-20516196-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3182
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.59246
GSE234289_4_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Anterior olfactory nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.49537
EGR2_01_243	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.67711
BRD-K62263376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85292
ATPAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60504
Dlx4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	13.764
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11337
neurological speech impairment	GWASdb SNP-Phenotype Associations	1.0	0.447865
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78528
PNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8152
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.936704
MFSD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72117
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9075
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055129
Shox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.7454
IZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02923
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1209
Vesicular gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
BRD-K95573463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32058
NFYA	ENCODE Transcription Factor Targets	1.0	null
integral component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.093686
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7325
GSE145323,GSE145324_9_v_2_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61440521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05271
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13445
BRD-K26904107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29241
pr82	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.176
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PSMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77805
EFEMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81305
DNAJC25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4598
tfap2c_18353300_e16dot5_skin_lof_mouse_gpl1261_gds3171	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.020664
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9773
OC-314	GDSC Cell Line Gene Expression Profiles	-1.0	-2.46266
TMEM161A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81045
Taenia tecta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.60272
Olfactory areas	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00225
spleen	HPA Tissue Gene Expression Profiles	1.0	0.923709
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
A673	GDSC Cell Line Gene Expression Profiles	1.0	1.79214
Mathematical Ability	DisGeNET Gene-Phenotype Associations	1.0	null
Mouse - Motor Cortex - Cluster - Lamp5+ Egln3+ GABAergic neuron_3	HuBMAP Azimuth Cell Type Annotations	1.0	null
type 2 diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.537959
TFCP2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86946
layer 2 of VPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09263
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ovary	HPA Tissue Gene Expression Profiles	1.0	1.16672
learning disability	GWASdb SNP-Disease Associations	1.0	0.448296
NRK cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.893
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Hyperostosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
LB647-SCLC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MPS IV - Morquio syndrome B	Reactome Pathways 2014	1.0	null
BRD-K25907192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20723
PM20D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15428
BRD-K43000271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59025
GSE161864,GSE161866_4_v_3_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6744
abnormality of higher mental function	GWASdb SNP-Phenotype Associations	1.0	0.32549
Subiculum, dorsal part, stratum radiatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58209
Brain_CT2_Splat 364	HuBMAP ASCT+B Annotations	1.0	null
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of the upper urinary tract	GWASdb SNP-Phenotype Associations	1.0	0.133738
SNU81	CCLE Cell Line Gene Expression Profiles	-1.0	-1.87229
L1236	CCLE Cell Line Gene Expression Profiles	1.0	3.40842
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61191
BRD-K67843691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63121
BRD-K08000110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3471
Lateral reticular nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35771
Cocaine-Related Disorders	HuGE Navigator Gene-Phenotype Associations	1.0	null
LPCAT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95875
AR-22383394-PROSTATE-CANCER-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K90644597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07147
layer 1 of InsCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03006
Heparanase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.979
FMNL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1481
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9253
SYAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02541
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23497
NCI-H524	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19731191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12137
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FAM120B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85166
ZIC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13596
Acute Myeloid Leukemia_LAML_TCGA-AB-2843-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K57359365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43715
GSE187006_0_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A2780	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RBM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84485
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48351
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K9ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PRPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82946
PMC8144624-41598_2021_90212_MOESM2_ESM.xlsx-6_hrs_ps_LPS-Duck_gene_name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Serotonergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.974
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
loci	GeneRIF Biological Term Annotations	1.0	null
BRD-K58835676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18489
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29723
CRCGN011_HEPG2_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00455
BRD-K91387865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11186
cuneus, left, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21506
anteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43442
K029AX	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36267
heparin biosynthetic process	GO Biological Process Annotations 2015	1.0	null
KYSE-520	COSMIC Cell Line Gene Mutation Profiles	1.0	null
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
Subiculum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20001
Calu-6	GDSC Cell Line Gene Expression Profiles	1.0	2.35621
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
gigantocellular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.959934
LRRC73	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12128
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6485480__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K18561719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04371
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Retinoschisis_Retina_GSE5581	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.07842
Fasciolar gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.023
Brain Lower Grade Glioma_LGG_TCGA-DH-A7UR-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bed nuclei of the stria terminalis, anterior division, fusiform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07826
speech-language disorder-1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.71
HH	COSMIC Cell Line Gene CNV Profiles	1.0	4.51153
hippocampus (hippocampal formation)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21827
PMC4598026__F5	PFOCR Pathway Figure Associations 2023	1.0	null
CUX1-19635798-MULTIPLE-CANCER-TYPES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Pentamidine (isethionate)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00555162
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OPM-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K85162983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36338
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9109
GSE142684_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.828101
LCLC-97TM1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MAC2A	DepMap CRISPR Gene Dependency	1.0	5.45676
BRD-K84846130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30057
TMEM134	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30439
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Adrenocortical carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.926
RUNX2	ChEA Transcription Factor Targets	1.0	null
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6062
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.24328
C-33-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0022
BRD-K43982279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32199
18537972-TableS3	GeneSigDB Published Gene Signatures	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
gallbladder	HPA Tissue Protein Expression Profiles	1.0	3.26007
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U9-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LAPTM4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40728
ZNF638	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55007
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041729
RUFY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35245
ZNF385A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74204
cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041311
BRD-K24640918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74816
layer I of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.39619
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14282
HCC-78	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GDF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6957
ZNF878	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11207
NKX2-3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80208
C17orf75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48651
Declive (VI), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.05965
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0852
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of the fundus	GWASdb SNP-Phenotype Associations	1.0	0.200056
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Prelimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.98176
KLF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27464
temporotympanic muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32828
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.18
GSE142019,GSE142021_10_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RAB25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65012
PLOD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53387
EIF1AY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31995
VAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48508
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_7_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
VSNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35821
EIF3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55363
TAF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33434
sex chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.482467
subiculum, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.086
Primary somatosensory area, nose	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52104
PDCD6IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34597
brain	HPA Tissue Gene Expression Profiles	1.0	0.860925
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87754
specific learning disability	GWASdb SNP-Phenotype Associations	1.0	1.09488
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.852247
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054894
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00455
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
fibre tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.09474
lateral septal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1588
BRD-K86358396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37109
precuneus, right, superior lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.861505
PARD6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76956
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
ndst4	GeneRIF Biological Term Annotations	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.070029
496100635_HIP_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.39221
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.882984
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.905463
Prostate adenocarcinoma_PRAD_TCGA-HC-7738-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K21933068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37812
PCDHB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.30381
SKBR3	CCLE Cell Line Gene CNV Profiles	1.0	1.67917
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2099
TCFCP2L1-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
CAR-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
heparan sulfate proteoglycan biosynthetic process	GO Biological Process Annotations 2025	1.0	null
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.897835
abnormality of the globe	GWASdb SNP-Phenotype Associations	1.0	0.202773
nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
FOXA1	ENCODE Transcription Factor Targets	1.0	null
GSE112760,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
layer 3 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.01932
HS-GAG biosynthesis	Reactome Pathways 2024	1.0	null
BRD-K32906083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55552
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4759
H4C11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85171
Metabolism of carbohydrates	Reactome Pathways 2024	1.0	null
layer 3 of AOD cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.26417
BRD-K35308744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45014
GSE143692_2_v_1_trim8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ACSBG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79752
BRD-K85803608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58228
CRCGN015_HEPG2_48H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3317
debrisoquin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50378
BRD-K49292348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16337
NY	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ISG20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61431
superior parietal lobule, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.934657
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211931_1_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.875135
NCIH2081	CCLE Cell Line Gene Expression Profiles	1.0	1.51444
TCF4-23295773-U87-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE123022,GSE123030_2_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K34181077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11316
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.87754
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2468
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4387
H3K27me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Supplemental somatosensory area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33344
IRF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC251	CCLE Cell Line Gene Expression Profiles	-1.0	-2.49968
ZNF165	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80365
CLPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58101
primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.878369
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.868252
ANHX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25832
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNAI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35967
ZNF250	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75837
SKLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.66668
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lobule III	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10034
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8423434-mmc7.xlsx-SOX2_HENSM-Genes_n_2733_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Human - Motor Cortex - Cluster - SST+ KLHL1+ Layer 5-6 GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
18537972-TableS2	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC11995938-74_129_TableS2.pdf-10-LIN54_LIN54	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE248045,GSE248046_6_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95729740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97537
BRD-K38854468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10162
Adenosine 3',5'-diphosphate	HMDB Metabolites of Enzymes	1.0	null
BRD-K92879007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80254
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.67426
SLC2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2517
TCF7L2_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHLDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23461
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43095
MAP4K3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0307
TE10	CCLE Cell Line Gene CNV Profiles	1.0	1.33243
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
Field CA1, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00649
GSE80098,GSE80366_0_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10350077-media-7.xlsx-Microglia_P_LPS_All_Up_GO-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
polysaccharide biosynthetic process	GO Biological Process Annotations 2023	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
GSE124410_3_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SEMA3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90969
GON4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76766
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9091
NKG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62527
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
superficial stratum of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03171
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K98432726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57232
SQ1	CCLE Cell Line Gene CNV Profiles	1.0	1.66143
BRD-K95648552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7797
PIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68974
KCTD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91449
Posterior parietal association areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3862
SMAD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87791
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.45055
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.233
Field CA1, stratum radiatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02174
BHLHE23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47985
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0778
BRD-K80109782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88929
BRD-K51681402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20656
BRD-K32280984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20816
DCAF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31399
PRR14L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83665
CUX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68696
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.984774
UTY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03709
BRD-K63950697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43669
LONRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31427
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63357
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.869242
STAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16331
BRD-K86232198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15297
LIMK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64428
Taenia tecta, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.82334
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
gentamycin-sulfate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00863
HMGCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90213
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
ZNF713	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39699
BRD-K07781799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63633
PNMA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69298
CRCGN009_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22615
BRD-K04407772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67803
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.56939
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K96493283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04231
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47893
EFO-21	GDSC Cell Line Gene Expression Profiles	-1.0	-1.47567
SIRT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92685
Defective CHSY1 causes TPBS	Reactome Pathways 2014	1.0	null
Arx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.3442
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
HT115	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63182
macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05333
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.09741
lateral parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27053
PCBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01867
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3K_Peaks_wtYAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
molecular layer of S	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33282
TNFSF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19886
GSE145915_5_v_1_pcm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K56572622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41269
SDC2	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PITPNC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.887
JVM-2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.42833
ZNF496	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77624
H3K4me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K42367391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60183
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.6737
Specific language impairment	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.546
DHX58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43797
NCAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70518
Hereditary multiple exostoses	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
ATP5PD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08071
POTEI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90059
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VZ in postamygdaloid region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01975
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHMP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5238
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02304
lower respiratory tract disease	GWASdb SNP-Disease Associations	1.0	0.200496
ZR75_1	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
BRD-A04231641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14609
RPP25L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5441
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.8982
Sarcoma_SARC_TCGA-DX-AB2J-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K51335814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33978
CDK4_knockdown_133_GSE31534	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.59318
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.962281
BRD-K51972131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09847
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.04038
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.982942
decamethonium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74405
HMGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14204
ZNF76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99499
CAMSAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61598
EBF1-22473956-BONE-MARROW-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
PEBP1_KO_GDS4334_617_mouse_Pancreatic beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Metabolism of carbohydrates	Reactome Pathways 2014	1.0	null
Perturb_4422_KO_Eed_SRP172483	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.27739
CRCGN014_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46224
GSE149035_2_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7078
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSME3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97219
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SKMEL30	DepMap CRISPR Gene Dependency	1.0	3.14184
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31293
Omodysplasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_10359_KD_Ascl1_SRP340223	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
OLIG2-26023283-AINV15-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Pituitary	GTEx Tissue Gene Expression Profiles 2023	1.0	2.23832
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.93629
L1236	CCLE Cell Line Gene CNV Profiles	1.0	1.79544
BRD-K21051792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4041
Bed nuclei of the stria terminalis, posterior division, strial extension	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15346
globe disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
Subiculum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.146
TMEM35B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86378
Mouse - Motor Cortex - Subclass - Sst+ Chodl+ GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
PMC6089552-oncotarget-09-31018-s004.xlsx-compound_targets_chip_rnaseq-Chip-seq_derived_EWS-FLI1_targets_Bilke_et_al_2013_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.94031
Mucopolysaccharidoses	Reactome Pathways 2014	1.0	null
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4657
alcohol dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.720865
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.20527
central nucleus of the inferior colliculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15461
integral component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.159658
MPS IV - Morquio syndrome A	Reactome Pathways 2014	1.0	null
TE617T	CCLE Cell Line Gene Expression Profiles	1.0	1.99773
BRD-K09528868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18853
RNF169	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44182
sulfur compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-K22698363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30004
TMEM41A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99052
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07594
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.33
abnormality of the uvea	GWASdb SNP-Phenotype Associations	1.0	0.271658
BRD-K96133500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52645
Posterior parietal association areas, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03131
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7C-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_KO_TESTES_627_GENES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.859958
496100321_HIP_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.9073
MELJUSO	DepMap CRISPR Gene Dependency	1.0	2.51973
PSMD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66364
BRD-K92176613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20081
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28961
BRD-K92172862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1301
KLF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93218
Rkip1_KO_GDS4331_15_mouse_C57BL/C pancreas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K60716223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2539
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5201
PMC10111863-supp_gad.350269.122_Supplemental_Paun350269_FileS3.xlsx-A_ASCL1-regulated_DGE-geneID_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
AARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08429
layer 1 of LPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.54687
HLA-DOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84828
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
carbohydrate metabolism disease	GWASdb SNP-Disease Associations	1.0	0.391404
Primitive endoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.737
YAP1	ChEA Transcription Factor Targets	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
alcohol dependence	GWASdb SNP-Disease Associations	1.0	1.00407
dactinomycin_homo sapiens_gpl7172_gse12459	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bronchopulmonary dysplasia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
GSE195559_6_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
p3 portion of the substantia nigra pars reticulata	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05425
layer 1 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.43274
SOX2	ChEA Transcription Factor Targets	1.0	null
GATA3_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JO-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K88671309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0987
GPR173	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59446
DMRTC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7869
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33702
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051626
ES1	GDSC Cell Line Gene Expression Profiles	1.0	1.88605
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.920911
BRD-A81879813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44419
BRD-K05699155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0673
GSE126345_4_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2802
MDST8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27122
ABCB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6962
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE133087_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20839
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38684
Temtamy preaxial brachydactyly syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
SMIM20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05504
FAM91A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63405
carboplatin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11701
RNF121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84807
NCIH1355	CCLE Cell Line Gene CNV Profiles	1.0	1.51447
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE126345_9_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CASKIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29922
BICD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95359
layer 6 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.91954
tauopathy	GWASdb SNP-Disease Associations	1.0	0.571834
Vagina	GTEx Tissue Gene Expression Profiles 2023	1.0	3.4197
B4GAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67524
hTERT-RPE1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.867
ventral posteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58426
macelignan	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28636
ACVR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26718
NCI-H596	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K13472433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19822
BRD-K82477786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01174
Autistic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
BRD-K81954791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46941
FOXD4L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.30813
Lung adenocarcinoma_LUAD_TCGA-J2-A4AD-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF142	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06652
SNU-407	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
striatum_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.862896
H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K36228696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18562
DYNLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31525
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.8372
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
glucose metabolism disease	GWASdb SNP-Disease Associations	1.0	0.391404
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
WARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7417
Anterior cingulate area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.79759
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02872
Lung adenocarcinoma_LUAD_TCGA-80-5611-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04257723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31916
BRD-K25877330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.257
PBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32791
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCMH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12993
superficial stratum of the IG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.40971
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K25917968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04173
PMC11659402-41523_2024_709_MOESM3_ESM.xlsx-Sheet2-Down_genes_in_ESR1_mutant_within_top_10_and_consistent_in_at_least_40_comaparisons_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
alzheimer's disease	GWASdb SNP-Disease Associations	1.0	0.571834
colonic epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.955134
kidney disease	GWASdb SNP-Disease Associations	1.0	0.853791
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.814081
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TCL1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26253
HH	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
NSA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25395
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IRX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34185
BRD-K92460921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27287
KCNH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12246
VMRCLCD	CCLE Cell Line Gene Expression Profiles	1.0	1.70322
LONP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45774
Pyramus (VIII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50632
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
LNZTA3WT4	DepMap CRISPR Gene Dependency	1.0	3.23964
GSE128730_4_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perireunensis nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16114
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.33411
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QX-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MMADHC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86918
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_DN4_ChIP-seq_TCF3	Rummagene Transcription Factor Associations 2026	1.0	null
SERF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51337
superficial stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0174
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.638234
Lateral reticular nucleus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04116
CYP26A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09472
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormality of metabolism/homeostasis	GWASdb SNP-Phenotype Associations	1.0	0.074014
lateral hypothalamic area, anterior region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34223
fluphenazine-490	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5907
ZNF35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95296
Rectum adenocarcinoma_READ_TCGA-AG-3732-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83096
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
PIMREG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86023
TEAD4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Paraflocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02405
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.865077
coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.257711
RFX5	ENCODE Transcription Factor Targets	1.0	null
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POU3F2	ChEA Transcription Factor Targets	1.0	null
FDX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51647
GSE137818_5_v_0_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8144624-41598_2021_90212_MOESM2_ESM.xlsx-3_hrs_ps_LPS-Duck_gene_name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PIGC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26374
SPATC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44618
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Mouse - Motor Cortex - Cross-Species Cluster - Lamp5+ GABAergic neuron_5	HuBMAP Azimuth Cell Type Annotations	1.0	null
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.998374
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.982942
pravastatin-lactone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.90127
GSE121809_1_v_0_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7058-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049076
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.0619
KCNK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87224
SENP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0266
SYNCRIP_OE_GDS3575_87_mouse_C57BL/6 mice	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
ES3	GDSC Cell Line Gene Expression Profiles	1.0	1.49336
BRD-K47995281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25885
GSE203308_15_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NEO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07556
ZNF684	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20179
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00511
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.68025
heparin_homo sapiens_gpl570_gse12710	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:I01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24035
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.53844
NBN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06686
SMAD4-21799915-A2780-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
diabetes mellitus	GWASdb SNP-Disease Associations	1.0	0.739348
BRD-K89174739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13096
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LS-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K98976117	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16001
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-Genes_with_ATF3_combined_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
RAI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67333
ITPRIPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8571
communication disorder	GWASdb SNP-Disease Associations	1.0	0.525038
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ANXA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52293
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.567443
HOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8033
medial part of r3B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11518
CCK81	CCLE Cell Line Gene Expression Profiles	-1.0	-1.4529
z chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.1148
Selinexor _SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0112204
mantle zone of JcPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04822
embryoday6.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.882426
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2455
central gray of the pons, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09542
TEX261	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38809
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041537
BRD-K79334072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68381
principal sensory nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.955141
Ankylosing Spondylitides_macrophage_GSE11886	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.58602
pontine raphe nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.833867
CAPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29796
FIS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22744
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.8358
BRD-K90697690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58189
KMS26	DepMap CRISPR Gene Dependency	1.0	2.00632
Defective CHST14 causes EDS, musculocontractural type	Reactome Pathways 2014	1.0	null
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K65813214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34135
TC32	CCLE Cell Line Gene Expression Profiles	1.0	1.8465
SGTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36451
BRD-K51372689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35866
increased colon goblet cell number	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K06279388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14698
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1819
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.067503
ZXDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3455
core part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16173
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
WDR77	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8158
GSE143847_2_v_3_inhba_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K39192716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23128
Myeloid leukemia associated with Down Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
ARID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8851
CBX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87273
BRD-A67508925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01431
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HSFX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98891
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HSG	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.28859
BRD-K31672963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05525
PKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31307
ARID3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95479
receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.050609
ADCY6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52906
LLC-WRC 256 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.907
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41493
MLF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86597
Brain_CT2_Inh L1 SST DEFB108B	HuBMAP ASCT+B Annotations	1.0	null
TOR4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25484
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3173
KCNK12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95026
EBLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43944
substance dependence	GWASdb SNP-Disease Associations	1.0	0.292233
DLD1	DepMap CRISPR Gene Dependency	1.0	2.75684
glycoprotein biosynthetic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
dorsal part of JcP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04787
COA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10489
PMC11956947-media-4.xlsx-C_GSEA_gene_sets-TGAYRTCA_ATF3_Q6_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN011_HEPG2_24H:C05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02455
BRD-K45348630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07427
B4GALT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12086
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.99065
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5280-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100664_HIP_probable Alzheimer's disease_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.62432
ZNF277	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36372
TMEM14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77881
SMARCA4	ChEA Transcription Factor Targets	1.0	null
GSE126345_2_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMYD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34159
intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.093665
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.8192
PNKP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59046
BRD-K41141507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21137
SCO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40257
Brain Lower Grade Glioma_LGG_TCGA-EZ-7264-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PK45H	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59886
Nucleus x	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16154
PRUNE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44915
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11451
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
zona incerta	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.853495
dyslexia	GWASdb SNP-Phenotype Associations	1.0	1.09488
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.963719
midbrain raphe nuclei	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.52905
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.87083
BRD-K83836941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08863
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.955717
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCI-H2342	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sarcoma_SARC_TCGA-WK-A8XT-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LCLC-103H	GDSC Cell Line Gene Expression Profiles	-1.0	-1.62805
eye and adnexa disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ATN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37464
Diseases of glycosylation	Reactome Pathways 2014	1.0	null
Anterior cingulate area, ventral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08245
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9164
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCML4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56068
MYOG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1246
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nicotine_myzus persicae_gpl9470_gse18658	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AM-095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42864
BRD-K29525414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28113
GSS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0568
OSBPL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00918
SCAMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85093
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K55510118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11853
SSTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54769
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MPS VII - Sly syndrome	Reactome Pathways 2014	1.0	null
GSE248045,GSE248046_0_v_5_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CAL27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53613
BRD-K20447569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18912
MDAMB361	DepMap CRISPR Gene Dependency	1.0	2.72412
MRPL32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37707
BRD-K85572169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54244
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAFK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05193
Cmah_KO_GDS4770_421_mouse_muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
organonitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
m4	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
BRD-K87404495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.52823
BRD-K73275682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11408
NCI-H2196	GDSC Cell Line Gene Expression Profiles	1.0	1.47394
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IGSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38081
JHU-011	COSMIC Cell Line Gene Mutation Profiles	1.0	null
C10orf88	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23445
EOL1	CCLE Cell Line Gene CNV Profiles	1.0	1.51697
ZNF316	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23651
clidinium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08625
BRD-K15380626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2741
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Posterior parietal association areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01938
Ventral posterolateral nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33702
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1525
BRD-K63330804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44978
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.80695
PPP1R14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61701
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12584
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37704
POR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65324
BRD-K77892726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01686
SMIM12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11463
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGFLR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7619
outer CP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01002
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Heparan sulphate-N-deacetylase	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K28375929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36851
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SESN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93288
BRD-K12115687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42524
LEUTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78984
NIHOVCAR3	DepMap CRISPR Gene Dependency	1.0	6.83812
ZBTB22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84917
RORA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2472
Anterior olfactory nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.05669
NCIH446	CCLE Cell Line Gene Expression Profiles	1.0	1.37365
abnormality of the endocrine system	GWASdb SNP-Phenotype Associations	1.0	0.137251
Brain_CT2_Inh L5-6 SST KLHL1	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
NCI-H2135	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Age At Menarche	DisGeNET Gene-Phenotype Associations	1.0	null
ZNF69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62098
SLC16A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66662
Central nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.911
AK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20108
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
KATNBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37009
OV7	DepMap CRISPR Gene Dependency	1.0	2.00553
GSE110524_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
interstitial nucleus of Cajal, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22764
GSE127790_13_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lung disease	GWASdb SNP-Disease Associations	1.0	0.594297
DPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70021
MYOD1	ENCODE Transcription Factor Targets	1.0	null
U20S	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.03591
SKNAS	CCLE Cell Line Gene CNV Profiles	1.0	1.84989
UNC13B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74371
central part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01989
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE162276_4_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
polysaccharide biosynthetic process	GO Biological Process Annotations 2025	1.0	null
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
amygdalostriatal transition area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.999743
abnormal intestinal epithelium morphology	MGI Mouse Phenotype Associations 2023	1.0	null
STAT3	ENCODE Transcription Factor Targets	1.0	null
CR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62788
LB2518-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040718
succinylcholine-chloride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52951
496100471_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.75988
GSE210101,GSE210114_6_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223008_5_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VPS37B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40876
GSE125219,GSE125221_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
associations	GeneRIF Biological Term Annotations	1.0	null
Posterior cardinal vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
MSANTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17405
Kidney Chromophobe_KICH_TCGA-KL-8341-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of r3BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13119
JUN-21703547-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K24259871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54638
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
EWSR1_KD_GDS4962_469_human_Ewing sarcoma and prostate cancer	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
TMK1	DepMap CRISPR Gene Dependency	1.0	14.2222
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CD83	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7158
ODF2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15979
PMC4773428-ncomms10751-s5.xlsx-S_Table_4-Supplementary_Data_4_RUNX1_responsive_genes_in_the_presence_and_absence_of_estradiol_E2_in_MCF7_cells_FC_1_5_p_0_05_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K84271926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17955
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Msx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.849
Anterior cingulate area, ventral part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67587
ARHGEF10L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9888
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2023	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LIVF001-017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53921
NCI-H1092	GDSC Cell Line Gene Expression Profiles	1.0	1.59063
ZNF80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60566
PMC9174176-41467_2022_30924_MOESM6_ESM.xlsx-OC2-SYMBOL_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
NUDT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79688
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K93486666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04371
ZSCAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21747
SUDHL6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77833
pontine reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.952283
layer 4 of OCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01022
ZNF578	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88834
SP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.914213
BRD-K35429158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34087
DUSP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44206
GSE164874_5_v_10_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
FBXO34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85773
RAD21_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75807319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.64907
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-ATF3_CBCTGACGTCANCS_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
GSE184902_4_v_1_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
oxoacid metabolic process	GO Biological Process Annotations 2015	1.0	null
RPL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90445
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04425
Basal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.576
ASMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52011
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
NFYB	ENCODE Transcription Factor Targets	1.0	null
IKBKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24152
JEKO1	CCLE Cell Line Gene CNV Profiles	1.0	2.06436
AR-22383394-PROSTATE_CANCER-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.071254
DMS153	CCLE Cell Line Gene Expression Profiles	1.0	1.58943
Prelimbic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64181
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.200881
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:A09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0579
SEC63	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24644
GSE203308_15_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Taenia tecta, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.73661
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38582
Human - Motor Cortex - Cluster - SST+ PIK3CD+ Layer 5-6 GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
transferase activity, transferring sulfur-containing groups	GO Molecular Function Annotations 2015	1.0	null
MARCHF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58135
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5748
MDAMB436	CCLE Cell Line Gene CNV Profiles	1.0	1.4381
peritoneal cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.475423
PMC8302638-41467_2021_24677_MOESM4_ESM.xlsx-S1_LMS_SNV-Supplementary_Data_1_Most_Recurrent_Non-Synonymous_Point_Mutations_in_LMS_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
ARFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39338
OGG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41114
SW620	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44455
Nervous system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.911
BRD-K44512951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12968
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17342
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4272
mucopolysaccharide metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K00381858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02737
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.889844
YMB1	CCLE Cell Line Gene Expression Profiles	1.0	1.48204
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.132819
Prelimbic area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.71124
496100547_HIP_no dementia_no TBI_82_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.14454
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q4-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
NCI-H1299	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52549
Coronary Arteriosclerosis	DisGeNET Gene-Disease Associations	1.0	null
Brain_CT2_Splat 364	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
IDS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01472
BRD-K57502201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78081
ICAM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30406
BRD-K21986392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01328
Interanteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.94932
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KCTD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94864
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
central part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23754
KELLY	CCLE Cell Line Gene Expression Profiles	-1.0	-1.9612
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.108296
PMC8423434-mmc7.xlsx-OCT4_HENSM-Genes_n_666_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
carbohydrate derivative metabolic process	GO Biological Process Annotations 2015	1.0	null
ZNF705D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9179
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039152
primary motor-sensory cortex (samples)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.961725
FUBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10576
ventral pallidum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01047
QGP1	CCLE Cell Line Gene Expression Profiles	1.0	1.77562
ACBD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13581
UBALD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17344
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.7007
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06453
RT11284	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34847
E2F4	ENCODE Transcription Factor Targets	1.0	null
BRD-K94293016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28561
H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Nr2e3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.9565
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36522
CAL72	DepMap CRISPR Gene Dependency	1.0	5.82288
RPMI7951	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67703
Brain Lower Grade Glioma_LGG_TCGA-FG-8182-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
FOXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.87254
lateral medullary reticular group, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2755
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1652
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.907798
PFSK1	DepMap CRISPR Gene Dependency	1.0	3.08467
CEP290	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96754
BRD-K51140037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15304
PEDS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65268
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.915695
BRD-K73427605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07522
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.0522
RNF182	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38815
CHRNA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12798
CPEB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82885
heparin metabolic process	GO Biological Process Annotations 2015	1.0	null
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.931659
ES7	GDSC Cell Line Gene Expression Profiles	1.0	2.0417
FURIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76925
8MGBA	CCLE Cell Line Gene Expression Profiles	-1.0	-2.13497
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.4482
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A896-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TTC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6364
Perturb_2615_Mut_SF3B1_SRP249914	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.5312
MDAMB231	CCLE Cell Line Gene Expression Profiles	-1.0	-1.8304
CRCGN008_HEPG2_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65705
CCAR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31643
NKX6-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02165
G292CLONEA141B1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46038
HS-GAG biosynthesis	Reactome Pathways 2014	1.0	null
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.741202
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06194
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067796
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
Chondrosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
GSE174701_4_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29306
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29659
FAM110C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00903
BRD-K85649685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01138
SETDB1_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Anterior olfactory nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.06919
VAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9405
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
midbrain raphe nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20682
BRD-K74988798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63635
BRD-K04873321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06158
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.65934
MHHES1	CCLE Cell Line Gene Expression Profiles	1.0	1.54284
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.4631
BRD-K41504921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.69545
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.856008
BRD-K56868780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2142
CDR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14686
SP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13204
UMC-11	GDSC Cell Line Gene Expression Profiles	1.0	1.57485
ZNF318	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63888
rostral presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13333
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IWS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87039
substantia nigra reticulata, isthmic part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10906
chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.124701
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EJ-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67769
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3615
HS939T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.89964
lateral mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01839
MAP1LC3B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98488
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.9236
primary auditory cortex (core)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.864618
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_SOX6_TrsFib_SOX6	Rummagene Transcription Factor Associations 2026	1.0	null
RH-1	GDSC Cell Line Gene Expression Profiles	1.0	2.47799
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3071
POLR2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74357
NCI-H1693	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TEAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79216
GSE151364,GSE151366_1_v_2_taf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SH2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55
Phosphoadenosine phosphosulfate	HMDB Metabolites of Enzymes	1.0	null
BRD-K91628074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43915
NCI-H1299	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LHX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5017
MAZ	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Heschl's gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.83573
increased enterocyte apoptosis	MGI Mouse Phenotype Associations 2023	1.0	null
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3126
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
nrf1_22586274_liver_lof_mouse_gpl4134_gse35124	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.176621
HAUS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48106
USF2	ENCODE Transcription Factor Targets	1.0	null
caudal presubiculum (postsubiculum)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.96847
single-organism biosynthetic process	GO Biological Process Annotations 2015	1.0	null
YAP1-20516196-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PIK3R4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99065
Brain Lower Grade Glioma_LGG_TCGA-P5-A77W-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central amygdaloid nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01375
subgranular zone of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.892196
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.955717
Perturb_16508_OE_Rest_SRP314492	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2714
Digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
lingual gyrus, left, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07909
SPTSSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3408
BRD-K27982554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43061
NEIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06388
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.59279
sulfur compound metabolic process	GO Biological Process Annotations 2015	1.0	null
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K70235890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16465
BRD-K85641667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38793
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3495
BRD-K36795325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21471
BRD-K99944747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14173
PMC11244912-media-3.xlsx-Sheet2-Down_genes_in_ESR1_mutant_within_top_10_and_consistent_in_at_least_40_comaparisons_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
GTF3C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99215
PLD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94431
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139948_3_v_2_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
glycosaminoglycan metabolic process	GO Biological Process Annotations 2015	1.0	null
RAB33A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29573
GSE201520_8_v_3_inhba_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC3348545-NIHMS263168-supplement-3.pdf-144-LEF1_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_7_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
CORO1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75024
Lung adenocarcinoma_LUAD_TCGA-91-6831-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superficial stratum of VPrP	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07449
ESS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MLXIPL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4509
heparan sulfate sulfotransferase activity	GO Molecular Function Annotations 2015	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70G-01B-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.85864
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K83272071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2342
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K95678449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21556
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
respiratory system disease	GWASdb SNP-Disease Associations	1.0	0.182059
THOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11415
CHP-126	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DACH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10298
UBE3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96452
SVIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29114
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.81858
MPS IIIA - Sanfilippo syndrome A	Reactome Pathways 2014	1.0	null
ARIH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17187
Folium-tuber vermis (VII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.8499
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K26187220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13383
NRDC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09825
TIE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26126
r8 part of lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1681
BRD-K22725588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11544
FAM210B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97157
CANT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66341
UBXN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62575
JHOM1	CCLE Cell Line Gene Expression Profiles	1.0	1.40733
GLUD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77879
FAHD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41127
Metapathway biotransformation(Mus musculus)	WikiPathways Pathways 2014	1.0	null
496100365_HIP_probable Alzheimer's disease_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.46279
RNASEH2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11713
ZBTB32	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3235
KYM1	DepMap CRISPR Gene Dependency	1.0	2.52654
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28394
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4691-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventral reuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30976
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF189	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19874
BRD-K55465787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90919
GRIN3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8276
CRCGN017_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56028
PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
496100393_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.75156
NCKAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98288
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K12107412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51889
RAD23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63294
small intestine	HPA Tissue Protein Expression Profiles	1.0	0.966054
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NC-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2672
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LENG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4806
SIPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17141
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8342
NIBAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21541
DAUDI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18238
Brain Lower Grade Glioma_LGG_TCGA-DU-7294-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skeletal muscle	HPA Tissue Protein Expression Profiles	1.0	0.966054
BRD-K82671459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00384
Fetallung	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.15251
CDK13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03041
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
MNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72399
BRD-A57474391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10891
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.962281
BRD-K03540982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45095
BRD-K34095226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27031
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.6262
caudate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00468
BAIAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.301
Hemcss	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.003
DMRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83248
abnormality of the eye	GWASdb SNP-Phenotype Associations	1.0	0.15859
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCIH2887	DepMap CRISPR Gene Dependency	1.0	2.95596
GSE145915_3_v_2_pcm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.5382
MCF7	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.882291
intestinal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.327164
HLA-C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97213
heparan sulfate proteoglycan biosynthetic process, chain elongation	GO Biological Process Annotations 2025	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Oligosaccharyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.181
RENT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.686
MMD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96343
Stat6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.7959
NCIH28	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42887
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039609
FOXA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05467
MTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60048
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.80708
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5282
TLE5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99414
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
superficial stratum of S	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29071
Lung adenocarcinoma_LUAD_TCGA-86-7955-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6337
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CHST12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60992
NCI-H1568	COSMIC Cell Line Gene Mutation Profiles	1.0	null
nucleus of Darkschewitsch, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.31706
BRD-K47001624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6826
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RLF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74771
Medial amygdalar nucleus, posterodorsal part, sublayer b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02092
BRD-K04810287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61418
MAFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4742
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15461
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.453
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4781
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.6935
CBFA2T2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12118
Anteromedial nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22228
Perturb_4423_KO_Eed_SRP172483	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.2539
MEL-HO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Disease	Reactome Pathways 2014	1.0	null
BICR 31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26471
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072423
AR-19668381-PC3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50726251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10802
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58815
inferior colliculus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.60986
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_15_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
ATP5MC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88087
CARD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75335
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66063
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	1.0	null
abnormality of the head	GWASdb SNP-Phenotype Associations	1.0	0.096849
RNF207	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09188
BRD-K83209781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00111
CCDC43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04891
cellular_component	GO Cellular Component Annotations 2015	1.0	null
GUF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57822
TMED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62243
mantle zone of S	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29071
PMC4598026__F5	PFOCR Pathway Figure Associations 2024	1.0	null
PMC10771438-41598_2023_51082_MOESM1_ESM.xlsx-Day14-Supplementary_Dataset_1_List_of_genes_differentially_expressed_during_NS_PC_differentiation_between_ROR2_KD_cells_and_control_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-ATF3_TGAYRTCA_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
ANKRD13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.59421
19074828-TableS4	GeneSigDB Published Gene Signatures	1.0	null
submedius thalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04632
OARD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53019
BRD-K92627732	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05972
Porencephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
LRCH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26642
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
R3HCC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49923
BRD-K68540120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18442
preoptic region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.60356
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF383	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74839
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052773
lingual gyrus, right, striate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.83143
MEL-HO	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5032
inner CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01409
COLO-684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EYA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42466
BRD-K83477969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39608
TC71	CCLE Cell Line Gene Expression Profiles	1.0	1.39918
Defective B4GALT7 causes EDS, progeroid type	Reactome Pathways 2014	1.0	null
septal nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15277
ZNF157	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98424
BRD-K91836330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07026
Perturb_16507_OE_Rest_SRP314492	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.40213
cellular macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
abdominal adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.567227
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
EN2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8304
MELAS - Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes_Muscle - Striated (Skeletal) (MMHCC)_GSE1462	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.84432
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Glycogen storage diseases	Reactome Pathways 2014	1.0	null
PGK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77099
heparan sulfate biosynthesis	KEGG Pathways	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7300-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 2 of LPrP cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11092
SYF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47305
MPS IX - Natowicz syndrome	Reactome Pathways 2014	1.0	null
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-5668-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
aminoglycan metabolic process	GO Biological Process Annotations 2015	1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.539
AOB, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12689
BLZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5888
IBTK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38927
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PELP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90393
EMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05884
Medial amygdalar nucleus, posteroventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.35213
ZBTB32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50521
MRPS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12958
ADAM17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1056
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
GSE133087_5_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MON1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24841
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20996
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.911
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K39179354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85172
PPM1F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76344
abnormality of the lung	GWASdb SNP-Phenotype Associations	1.0	0.505163
SKOV3	BioGPS Cell Line Gene Expression Profiles	1.0	0.902383
EW-16	GDSC Cell Line Gene Expression Profiles	1.0	2.07797
Breast pericanalicular fibroadenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.659
GSE211474,GSE212779_8_v_4_phf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ESR1-26153859-T47D-HUMAN-BREAST-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
RFX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94713
BRD-K66963616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24017
Perturb_9220_KO_Rai1_SRP074487	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.40097
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80703
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.739348
Defective B3GAT3 causes JDSSDHD	Reactome Pathways 2014	1.0	null
BRD-K43918778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94642
GSE109565_12_v_11_glyphosate_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H2227	COSMIC Cell Line Gene Mutation Profiles	1.0	null
maxdrinks	GeneRIF Biological Term Annotations	1.0	null
GSE93309_5_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67090914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55748
abnormality of the oral cavity	GWASdb SNP-Phenotype Associations	1.0	0.163043
HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9386
Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K55562948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15376
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.881655
BRD-K08527280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48073
Sulfotransferase domain	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K62213484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03482
OVTOKO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GPC1	Pathway Commons Protein-Protein Interactions	1.0	null
N4BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34813
abnormality of the tongue	GWASdb SNP-Phenotype Associations	1.0	0.659244
Metabolism	Reactome Pathways 2024	1.0	null
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.983774
KDM2B-26808549-CHIP-SEQ-REH-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7570-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K40474424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26744
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HUH7	DepMap CRISPR Gene Dependency	1.0	2.50757
GR-ST	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sarcoma_SARC_TCGA-QQ-A8VH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30948
CEP250	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80918
H3K27ac_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCI-H1838	COSMIC Cell Line Gene Mutation Profiles	1.0	null
retinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.256228
KLF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5716
CFAP97	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43278
Simple lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19684
abdomen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.112578
BRD-A12830281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15472
precentral gyrus, right, bank of the precentral sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.938803
mantle zone of AOV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.18642
FTC-133	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K37144511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13904
SK-MEL-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_7G-MAX_KO_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K96243955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09309
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
cuneate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07507
LOXIMVI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14516
HNRNPA2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47804
RFXAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47476
superficial stratum of AOD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83375
eye and adnexa disease	GWASdb SNP-Disease Associations	1.0	0.208437
superficial stratum of TTe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15831
Dyslexia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.257
Brain Lower Grade Glioma_LGG_TCGA-HT-7610-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32930844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56928
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
INF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09865
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.8643
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.373
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
cerebellar cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.965665
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.953539
all	GWASdb SNP-Phenotype Associations	1.0	0.069483
BRD-K45062933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60591
heparan sulfate N-sulfotransferase activity	GO Molecular Function Annotations 2025	1.0	null
HCC-33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K12824862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92936
GSE153064,GSE153065_1_v_2_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148010,GSE148120_3_v_2_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ARSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4173
GSE214382,GSE214383_6_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WF-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PXDNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93826
layer II of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60613
GSE174701_1_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GOTO	GDSC Cell Line Gene Expression Profiles	-1.0	-1.62387
BRD-K64246525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00448
IL17RE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69124
NCIH1694	DepMap CRISPR Gene Dependency	1.0	2.30286
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ribavirin_homo sapiens_gpl570_gds4391	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE131649_2_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41817
periventricular stratum of Str	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00468
SSR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39625
golgi apparatus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K73042446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40702
KLF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68224
Nucleus reuniens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.63
BRD-K80950551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03336
IZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.50201
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KLK13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60687
abnormality of erythrocytes	GWASdb SNP-Phenotype Associations	1.0	0.265282
golgi membrane	GO Cellular Component Annotations 2015	1.0	null
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66904
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5683-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A1BG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85948
CORL23	CCLE Cell Line Gene CNV Profiles	-1.0	-1.8633
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36836
huh-7	BioGPS Cell Line Gene Expression Profiles	1.0	1.20482
Pervasive developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
INTS13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.20359
BRD-K15236933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17515
L-1236	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RARA_KD_GDS4065_42_human_MCF-7	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
intermediate stratum of r4BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06618
layer 6a of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.92012
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049346
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null