association	dataset	threshold value	standardized value
ESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7492
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CTCF_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DL-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199092_2_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_2_TurboID_10m_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
PPP2R1B	Pathway Commons Protein-Protein Interactions	1.0	null
magnocellular (medial) subparafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61451
r9 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05159
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-73-7499-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A73559168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34126
BRD-K06926365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33546
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.60645
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14375485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19268
RPL6	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WHPG-0826-SM-3NMBF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75061
Barrett Esophagus_Esophageal Tissue_GSE1420	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.6018
ATP5J2	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09706
posteroventral (inferior) parietal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.46465
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.051151
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.847496
TE4	CCLE Cell Line Gene Expression Profiles	1.0	1.57543
proton motive force-driven mitochondrial ATP synthesis	GO Biological Process Annotations 2023	1.0	null
H4K20me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37159
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
GTEX-NL3H-0011-R3a-SM-2I3GL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86555
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125782_0_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE104604_1_v_0_eif5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62492257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45858
Perturb_6988_OE_Erbb2_SRP245626	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K83949633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92253
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-O5YT-1026-SM-3MJGF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890278
BRD-K53168433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39363
Supramammillary nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.63116
PMC6352376__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-XQ3S-0526-SM-4BOQA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6565
Respirasome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.45048
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA92593	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.76
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.482
Mitochondrial DNA depletion syndrome 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.912
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.86104
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173201_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PSMA1	Pathway Commons Protein-Protein Interactions	1.0	null
Obesity-related traits	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29541
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dexamethasone_mus musculus_gpl339_gds2314	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.936927
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-A06232236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01603
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03367
heart	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE252857_2_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
KRTCAP2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K40674409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2371
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-0326-SM-2XCFI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.886903
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.963058
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A680-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K58876832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39897
REST	ENCODE Transcription Factor Targets	1.0	null
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.79163
cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922391
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18673
Adrenomedullin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.536
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
SLC25A5	Pathway Commons Protein-Protein Interactions	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.31775
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP5D	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899406
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.70325
mitochondrial encephalomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.27563
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Supramammillary nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00242
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
respiratory chain	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
17676974-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Mitochondrial respiratory chain complex IV	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.591
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.92159
GSE166944_0_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-W5X1-0826-SM-3GILN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16288
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K31300534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12511
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.31137
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20636
posterior (caudal) superior temporal cortex (area 22c)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.973804
SOX2	ChEA Transcription Factor Targets	1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59544784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42924
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.78854
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.061362
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.90383
UBE2T	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75579
TUBA4A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K20798215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69556
C11orf71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86779
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DHRS7	Pathway Commons Protein-Protein Interactions	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055094
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.570892
Perturb_5676_KD_Kdm5b_SRP362502	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.06298
1410_CDC73_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.560874
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.9535
19965622-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00849
KLHL14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572614
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876326
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12527
ATF3	ENCODE Transcription Factor Targets	1.0	null
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51242
Midline group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27631
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53907
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04719
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47232
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862423
MCF7_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141232
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.47957
GSE193282_2_v_0_cd44_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37111
KPNB1	Pathway Commons Protein-Protein Interactions	1.0	null
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
17638893-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K00381858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97509
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
MONOMAC1	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.25963
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
FLI1	ChEA Transcription Factor Targets	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59161
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A519-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
JJN3	Achilles Cell Line Gene Essentiality Profiles	1.0	1.01051
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046784
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877143
Leber hereditary optic neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.412
RPL19	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERP44	Pathway Commons Protein-Protein Interactions	1.0	null
forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Psoas_Muscle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.844763
6696_PPP4C_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.818389
organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.19733
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.34873
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.17378
NDUFS6	Pathway Commons Protein-Protein Interactions	1.0	null
CPT2	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1	Pathway Commons Protein-Protein Interactions	1.0	null
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.465676
Urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.10026
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.30002
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895992
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.38716
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.69275
BRD-K81982648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6653
YY1-21170310-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
17616640-TableS1	GeneSigDB Published Gene Signatures	1.0	null
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.47457
BRD-K27671601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93213
CRCGN017_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.72535
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.758362
Gracile nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68809
HDAC6	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4583-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06866
SLC7A5	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.063
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826609
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.310782
CTCF_mammary epithelial cell_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU349	CCLE Cell Line Gene Expression Profiles	-1.0	-2.61448
KP2	Achilles Cell Line Gene Essentiality Profiles	1.0	1.10638
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.877557
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7221
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AP1G1	Pathway Commons Protein-Protein Interactions	1.0	null
intermembrane	GeneRIF Biological Term Annotations	1.0	null
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.8808
Neural stem cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.767
CTCF_fibroblast of villous mesenchyme_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16714
Perturb_4320_KO_Fmn2_SRP109283	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.60849
ZNF230	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69979
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.29545
ndufa8	GeneRIF Biological Term Annotations	1.0	null
Hypertrophic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.196
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04052
JURLMK1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.85668
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72624
NCIH1793	CCLE Cell Line Gene CNV Profiles	1.0	1.35281
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VPS13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04009
Uterine endometrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.547
Lung adenocarcinoma_LUAD_TCGA-35-3615-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLPP	Pathway Commons Protein-Protein Interactions	1.0	null
P4HA1	Pathway Commons Protein-Protein Interactions	1.0	null
BNIP3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02846
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.831917
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.679975
NDUFS4	Pathway Commons Protein-Protein Interactions	1.0	null
Muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.195
Mitochondrial ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.912
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.92565
PMC10624900-41467_2023_42825_MOESM13_ESM.xlsx-Module_3-ZNF195_ZNF195	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS22	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QV44-0526-SM-2S1RE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76499
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.87482
YBX1	Pathway Commons Protein-Protein Interactions	1.0	null
EM2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6428
VIM	Pathway Commons Protein-Protein Interactions	1.0	null
catalytic complex	GO Cellular Component Annotations 2015	1.0	null
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03033
PMC6643872__F2	PFOCR Pathway Figure Associations 2024	1.0	null
FANCI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19138
SNU349	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50529
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.848984
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.955738
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
oxidoreduction-driven active transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.55081
18787207-TableS2	GeneSigDB Published Gene Signatures	1.0	null
RPL31	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.7262
SW1783_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.04239
BRD-K52838863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12013
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_3_TurboID_1hr_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.915495
BRD-K45819372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1786
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NDUFA9	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic Neoplasms	CTD Gene-Disease Associations	1.0	1.20816
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mitochondrial envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.143
envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.22385
PRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08998
IZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10879
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.71045
GTEX-OXRL-0326-SM-2I3F2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.31454
LOX-1_OE_GDS4262_434_human_HAECT - aortic endothelial cell line - 12 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ALL-PO	GDSC Cell Line Gene Expression Profiles	-1.0	-1.55157
epithalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.501574
GTEX-XQ3S-0626-SM-4BOOB	GTEx Tissue Sample Gene Expression Profiles	1.0	4.12118
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.839636
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.956983
GTEX-S4P3-0626-SM-4AD59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878174
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.354
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896471
CTCF_A549_hg19_10	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K46790201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14654
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table3_WBBC_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27501
BV173	CCLE Cell Line Gene CNV Profiles	-1.0	-2.16439
DBTRG05MG	CCLE Cell Line Gene Expression Profiles	1.0	1.66059
GTEX-UJHI-0626-SM-3DB8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981769
TFRC	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K89366873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36297
SMC4-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.05205
STAT1	Pathway Commons Protein-Protein Interactions	1.0	null
SNRNP200	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22117
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.96748
thorax	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
ZNF728	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09316
TRUB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06566
obesity	GWASdb SNP-Phenotype Associations	1.0	0.899912
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHMP2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00725851
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.405474
OTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89214
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.528655
diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.118933
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02113
PMC12289921-41467_2025_62099_MOESM4_ESM.xlsx-MI-2-80-Gene_Symbol_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7SF-0526-SM-3K2BC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990201
Ebolavirus(ZEBOV)_3day_PBMCs_rNAPc2treated_21987740_GSE24943	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.178752
contains	GeneRIF Biological Term Annotations	1.0	null
urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0229
GSE77795_2_v_1_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.247079
BRD-K63654001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54137
Pulmonary Edema	CTD Gene-Disease Associations	1.0	1.059
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16877
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A67A-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE249893_1_v_0_tfam_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186647,GSE217288_11_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.6042
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03557
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1876	CCLE Cell Line Gene CNV Profiles	1.0	1.85866
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Microcephaly	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z1-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAD21_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tcof1_15522210_neuroblastoma_gof_mouse_gpl339_gds998	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.071244
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.984468
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75983763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70017
membrane part	GO Cellular Component Annotations 2015	1.0	null
BCL7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25898
Mitochondrial myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.604655
143B cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.029
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51958
GTEX-XQ8I-0226-SM-4BOPM	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11018
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249032
COLO205_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.33107
USMG5	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acquired Immunodeficiency Syndrome	HuGE Navigator Gene-Phenotype Associations	1.0	null
IB-94-WM88_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236689
NDUFA12	Pathway Commons Protein-Protein Interactions	1.0	null
ABCB7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K72519622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36572
CTCF_astrocyte of the spinal cord_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUBB4B	Pathway Commons Protein-Protein Interactions	1.0	null
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
SCAMP3	Pathway Commons Protein-Protein Interactions	1.0	null
IZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37128
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hela	HPA Cell Line Gene Expression Profiles	1.0	0.976816
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.09537
GTEX-WFG7-0826-SM-3GIKU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25634
BRD-K88038091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88701
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25847
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57023
hsa-miR-585	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Methane monooxygenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.546
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.57755
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.905105
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
retromammillary area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08611
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
ONS-76	GDSC Cell Line Gene Expression Profiles	1.0	1.6207
SPSB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15062
TCEB2	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6AW-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Spinal Muscular Atrophy, Infantile_CNS - Spinal Cord (MMHCC)_GSE3075	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.78138
BRD-K27476515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14849
primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.954351
IPO13	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K55853030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32017
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.032
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A69E-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4553
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.911239
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SACM1L	Pathway Commons Protein-Protein Interactions	1.0	null
CALM1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
skeletal muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
HS936T	CCLE Cell Line Gene Expression Profiles	1.0	1.68422
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246049
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HSPBP1	Pathway Commons Protein-Protein Interactions	1.0	null
ERCC3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990598
GSE100217_2_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
gastric mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.30032
Nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.812
CTCF_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RH18	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64394
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A57536034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08483
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.063
GSE248858_6_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149075_6_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8919
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
r8 part of basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28007
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.897144
FOXK1	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial DNA depletion syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.338
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.81516
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.68622
IDH3B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AKT1_knockdown_123_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.82376
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
GTEX-SJXC-0426-SM-2XCFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925309
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63705
ChIP_STAT3_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MLF2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
6696_PPP4C_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.07801
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TT	Achilles Cell Line Gene Essentiality Profiles	1.0	1.41245
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.030627
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.05275
oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor	GO Molecular Function Annotations 2015	1.0	null
CPNE9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01806
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878373
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JF-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EFO-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20358
GTEX-S4UY-0006-SM-3K2A7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27717
GSE88819_5_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K40264914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20484
inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.923013
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58521
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.17383
11152_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.763278
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.424
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP5C1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_foreskin fibroblast_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37798
Lung adenocarcinoma_LUAD_TCGA-62-A471-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08292
BRD-K39546571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05156
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PSDG-0926-SM-2I5FP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88734
LONP1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3614
Lymph	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PGRMC1	Pathway Commons Protein-Protein Interactions	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.855041
LMAN1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE227592_0_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56292
liver cirrhosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.21974
CTCFL_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWN1-1826-SM-2S1PE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847215
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56544
SEC61A1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873061
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMARCC1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K49707067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34462
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.77566
external part of AOV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.70103
BRD-K63950697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45794
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPP2R5E	Pathway Commons Protein-Protein Interactions	1.0	null
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4344782__F11	PFOCR Pathway Figure Associations 2024	1.0	null
MALME 3M	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.25665
VAChT_KD_GDS4325_361_mouse_Heart from C57BL/6 males	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6405
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K80763723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54059
CRCGN015_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5656
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-3923-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VAPA	Pathway Commons Protein-Protein Interactions	1.0	null
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20023
r9 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08516
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
basal nucleus of Meynert	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22645
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrial inner membrane	GO Cellular Component Annotations 2025	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68W-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210037
SARS-CoV_60Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.65962
BRD-K74755318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07202
shsy5y	HPA Cell Line Gene Expression Profiles	-1.0	-1.10246
RAB5C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K54233340_Dorsomorphin dihydrochloride_THP1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06284373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10349
SW1417	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.03134
intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Calu-6	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.99227
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of lung_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IM-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K42879623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63956
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5113
CTCF_epithelial cell of esophagus_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845838
Ebolavirus(ZEBOV)_7day_PBMCs_rNAPc2treated_21987740_GSE24943	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.204406
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-01A-31R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitochondrial encephalomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.475
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim29_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.82922
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01588
H3K27ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043456
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18458
STAT3	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.286245
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91459
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU72-0326-SM-2TF5T	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02024
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4W-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBC1D4	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88343
H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MICOS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.23
NTAQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06988
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.826257
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGF2BP2	Pathway Commons Protein-Protein Interactions	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053381
H3K27me3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QXCU-0926-SM-48FEP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981558
CRCGN017_MCF10A.WT.HP_24H:I21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11775
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8948
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.03414
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.898979
Norwalk Virus_HG23_19515767_GSE15520	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.58459
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31855
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WY7C-0526-SM-3NB3D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2681
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MF-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXA7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.0948
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
brain	GTEx Tissue Gene Expression Profiles	1.0	0.89492
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19356
P68-20966046-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04261
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14854
GSE114992,GSE114993_0_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PPP1R13B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79955
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
lactic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.586665
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A118-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
REV3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20913
TMED2	Pathway Commons Protein-Protein Interactions	1.0	null
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276371
GTEX-P4PQ-1626-SM-2HMKK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834708
RFX5	ENCODE Transcription Factor Targets	1.0	null
HEC1A	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.34935
BRD-K87558616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08279
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920786
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.17043
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02113
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24341
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.032
CTCF_fibroblast of lung_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE168797_4_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00138
PTEN_KD_GDS4759_337_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
increased heart rate variability	MGI Mouse Phenotype Associations 2023	1.0	null
HEATR1	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948398
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2073
Epicuticle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.5
pioglitazone_homo sapiens_gpl570_gds4132	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Stomach	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.551153
Left ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.144
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.91021
EM2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.82315
PMC10969083__F7	PFOCR Pathway Figure Associations 2024	1.0	null
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2025
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.15448
CTCF_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52158
r8 part of nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43592
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16714
MHH-CALL-2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.92016
9420_TUBB_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.907973
ACTB	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE149769_1_v_0_nlrp12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05194
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08942
POLD1	Pathway Commons Protein-Protein Interactions	1.0	null
pineal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.550901
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.058
BRD-K96776591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86758
BRD-K75073374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58783
PMC10654515-41467_2023_43245_MOESM4_ESM.xlsx-Putative_ERG_binding_proteins-Unnamed_1_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
inner SZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.975771
BRD-A61778798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37426
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08062
PSMB1	Pathway Commons Protein-Protein Interactions	1.0	null
PSMC2	Pathway Commons Protein-Protein Interactions	1.0	null
Dyslipidemias	CTD Gene-Disease Associations	1.0	1.33228
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16755
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S32W-0626-SM-2XCBG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5322
Basolateral amygdalar nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08263
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26098
GTEX-QDVJ-0426-SM-2I5FW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40216
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16911
BRD-K49745710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.58994
nadh dehydrogenase complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-T8EM-0826-SM-4DM76	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01656
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19424
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOD1	ENCODE Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.17474
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32995
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
PMC6021240-oncotarget-09-27605-s009.xlsx-Sheet1-STAT5A_STAT5A	Rummagene Transcription Factor Associations 2026	1.0	null
MDAMB436	CCLE Cell Line Gene Expression Profiles	1.0	1.47989
CHCHD3	Pathway Commons Protein-Protein Interactions	1.0	null
SHOC2	Pathway Commons Protein-Protein Interactions	1.0	null
MGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00308
G-361	GDSC Cell Line Gene Expression Profiles	1.0	1.58929
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QXCU-0626-SM-2TC69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31744
dorsolateral part of Int	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25177
BCAP31	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ME-344	DGIdb Drug Targets 2026	1.0	0.35288
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSPA6	Pathway Commons Protein-Protein Interactions	1.0	null
proton motive force-driven ATP synthesis	GO Biological Process Annotations 2023	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
CTCF_astrocyte of the spinal cord_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09489
NDUFS1	Pathway Commons Protein-Protein Interactions	1.0	null
M6PR	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K87275815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16421
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47W-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2H1-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16401
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
Uterine leiomyoma_Uterus - Myometrium (MMHCC)_GSE593	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.47091
DNAJC11	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11166884-mmc4.xlsx-Table_S3-Table_S3_proinflammatory-EC2_comparison_between_WT_and_TG_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.661233
nadh dehydrogenase complex	GO Cellular Component Annotations 2015	1.0	null
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334256
Rectum adenocarcinoma_READ_TCGA-EI-6883-01A-31R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FF-86-NH56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.426496
SLC25A1	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277015
BRD-K81465091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45172
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.875674
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RUVBL2	Pathway Commons Protein-Protein Interactions	1.0	null
SW-480 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.30892
H3K27ac_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
urinary bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.154
Prostate adenocarcinoma_PRAD_TCGA-KK-A59X-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14753
Pathways of neurodegeneration - multiple diseases	KEGG Pathways 2026	1.0	null
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07957
ATP1A1	Pathway Commons Protein-Protein Interactions	1.0	null
r8 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.12737
XRN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00790321
USP7	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A617-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-10-HD17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35108
Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IKBKAP	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08857
BRD-K38854468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48344
BRD-K61590534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2083
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.29039
mitochondrial matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.228108
Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.32291
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IMMT	Pathway Commons Protein-Protein Interactions	1.0	null
hMPV_6Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.41898
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-UTHO-0011-R6A-SM-3GIJW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860236
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5
Respiratory chain complex II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.888
nucleus accumbens, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.850863
gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PHB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7772566__F6	PFOCR Pathway Figure Associations 2024	1.0	null
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.601951
PMC5840266-41598_2018_22384_MOESM13_ESM.xlsx-UBE3A_KD_significant-Unnamed_23_AR	Rummagene Transcription Factor Associations 2026	1.0	null
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.914859
BFTC909	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46971
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2819-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organelle envelope lumen	GO Cellular Component Annotations 2023	1.0	null
9469_TYW3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.510595
CCNT2	ENCODE Transcription Factor Targets	1.0	null
Female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
Prostate adenocarcinoma_PRAD_TCGA-J4-A67L-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.519921
DNAJB1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12315868-Supplemental_Data_S1.xlsx-Supplemental_Data_S1F-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00139
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897122
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OZ-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE230263,GSE230265_0_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UBE3C	Pathway Commons Protein-Protein Interactions	1.0	null
GSE207914_2_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Diencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
respiratory chain	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.535772
E2F1	ChEA Transcription Factor Targets	1.0	null
CRCGN008_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34265
MKN45	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40059
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE87299_1_v_0_nr1d1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.20092
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76976010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24142
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Renal clear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
CB-16-SY72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.19641
CRCGN011_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7706
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
DPM1	Pathway Commons Protein-Protein Interactions	1.0	null
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10385824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46961
MBD3	Pathway Commons Protein-Protein Interactions	1.0	null
GCDH	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K13076765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68251
ATXN10	Pathway Commons Protein-Protein Interactions	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K36120694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2129
Amyotrophic lateral sclerosis	KEGG Pathways 2026	1.0	null
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OAT	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K24170552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58118
BRD-K81999794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1834
BRD-K19435356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22647
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.57795
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
metencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8462_SSX2IP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.578716
organelle part	GO Cellular Component Annotations 2015	1.0	null
RFC3	Pathway Commons Protein-Protein Interactions	1.0	null
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997855
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZF-1526-SM-3MJGY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86406
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16586
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54936
Non-alcoholic fatty liver disease	KEGG Pathways 2026	1.0	null
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PSPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93286
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ndufs5	GeneRIF Biological Term Annotations	1.0	null
TENC1	Pathway Commons Protein-Protein Interactions	1.0	null
central part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.17569
Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TIGD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05579
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A57982699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60967
Lung adenocarcinoma_LUAD_TCGA-75-7031-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NADH dehydrogenase (quinone) activity	GO Molecular Function Annotations 2023	1.0	null
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATP5J	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2867
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.42329
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TMEM88	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09975
inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.407172
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874867
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TE-4	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
5730_NOC3L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.586704
BRD-K71227259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01375
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.341767
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.94547
BRD-K58756877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63357
MAPKAP1	Pathway Commons Protein-Protein Interactions	1.0	null
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.236
BRD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00585767
BRD-A67697194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38133
BRD-K96845170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81939
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
retroreuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75156
SKRC31	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64084
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r9 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1554
PU1-27457419-CHIP-SEQ-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
r10 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51085
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2079
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35677
GSE133516_0_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.475494
BRD-K55147629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.96445
CRCGN015_MCF10A.TP53.M_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11045
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8668_TAF6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.52762
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Dhori Virus_12Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.99035
AP1M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1209
SUP-B15	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.43374
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.6716
OSGEP	Pathway Commons Protein-Protein Interactions	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
Water vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.733
CSTB_KO_GDS5089_169_mouse_Cerebrellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SUCLG1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
organelle	GO Cellular Component Annotations 2015	1.0	null
Respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.463
GTEX-XGQ4-0526-SM-4AT6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60319
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4439
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.622
CRCGN017_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.135
organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.496205
SARS-ddORF6_96Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.98554
RPL29	Pathway Commons Protein-Protein Interactions	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055774
Sarcoma_SARC_TCGA-K1-A3PN-02A-11R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
Metabolism	Reactome Pathways 2024	1.0	null
GSE145311_0_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Lateral ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.063
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LAMP1	Pathway Commons Protein-Protein Interactions	1.0	null
VMRCRCZ	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68789
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CYB5R3	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-D-Enh_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
c-MYC_KD_GDS2526_112_human_MCF-7 BREAST CANCER cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC10913870-pr3c00632_si_001.pdf-62-ZNF451_ZNF451	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARL8A	Pathway Commons Protein-Protein Interactions	1.0	null
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8561
BRD-K76654183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25861
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
OSBPL8	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKOV3	Achilles Cell Line Gene Essentiality Profiles	1.0	2.00638
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.71985
PL21	CCLE Cell Line Gene Expression Profiles	-1.0	-2.0538
BRD-K67980010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44202
LN18	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.02907
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.700012
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUBG1	Pathway Commons Protein-Protein Interactions	1.0	null
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.032
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.18508
HeLa-S3 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-2.53176
CTCF_astrocyte of the cerebellum_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46195
medial pretectal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18368
HNRNPH1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40455
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18611
Perturb_8654_KO_ESRRA/ESRRG_SRP304242	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MYO5C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K44641066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14517
FANCI	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169152_5_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2925_FAM50A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.565405
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.909757
Lung cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
HDAC1	ENCODE Transcription Factor Targets	1.0	null
GSE88819_11_v_4_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
xylometazoline-1423	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13284
PSMD6	Pathway Commons Protein-Protein Interactions	1.0	null
GSG2	Pathway Commons Protein-Protein Interactions	1.0	null
HCC515	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.518
GSE199874_4_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4955
RCC4	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50173
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.85834
TCCSUP	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.19863
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.963975
TOV21G	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.33439
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3465-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r10 part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75928
Transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.114
BRD-K89277562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35694
FOXP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35956
Duchenne muscular dystrophy (DMD)_Muscle - Striated (Skeletal) (MMHCC)_GSE1025	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.62495
CTCF_astrocyte of the cerebellum_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.898086
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.824865
TUBB2A	Pathway Commons Protein-Protein Interactions	1.0	null
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43049
CRCGN015_HEPG2_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42798
BRD-K35935439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06815
Salivary gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.518
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A857-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cardiovascular system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38421
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32527
GTEX-XUJ4-0526-SM-4BOON	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74727
NOMO3	Pathway Commons Protein-Protein Interactions	1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
Brain - Caudate (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.771033
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01082
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCT116	BioGPS Cell Line Gene Expression Profiles	1.0	1.16193
DNAJC7	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24275
periventricular stratum of r10Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75928
DTX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0048725
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBED-0526-SM-47JY3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6036
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3487
UNC119	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13302
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16714
C18orf32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42149
PSMA3	Pathway Commons Protein-Protein Interactions	1.0	null
TRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PM-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SARS-BatSRBD_96Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.73284
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.76747
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
GSE151494_8_v_3_nrp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K03608799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35056
CTCF_GM12874_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965507
Mitochondrial outer membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.961
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
vitamin c_homo sapiens_gpl570_gse11919	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC39A7	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42949
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
Cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
SW1990	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.24763
8816_TELO2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.512196
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.83263
Perireunensis nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10537
BRD-K58194737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38369
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37741838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86205
GF-37-MB64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209529
DMS454	CCLE Cell Line Gene Expression Profiles	1.0	2.03011
heart	GTEx Tissue Gene Expression Profiles	1.0	2.18722
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0332
cecum	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
7814_SETD1A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.585674
AIFM1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6373-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TOMM22	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927231
CTCF_GM12870_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51555
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
captopril_mus musculus_gpl1261_gds3683	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K24350933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68171
GSE147876,GSE147877_4_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lower basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05548
EPCAM_OE_GDS4887_342_human_IL-28B	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K22606370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0551
GSE248858_4_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A61014366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06889
GTEX-WI4N-0626-SM-3TW8Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881853
hippocampus (hippocampal formation)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.913125
Thermogenesis	KEGG Pathways 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65B-01A-12R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243478
rosiglitazone_mus musculus_gpl1261_gse11343	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS3A	Pathway Commons Protein-Protein Interactions	1.0	null
NDUFB10	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.03
SR786	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7982
Hemorrhage	CTD Gene-Disease Associations	1.0	1.31
DIMT1	Pathway Commons Protein-Protein Interactions	1.0	null
mantle zone of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51085
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPIC-0726-SM-3GADW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889932
GSE231891_5_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
ME1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.5783
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CSTB_KO_GDS5089_565_mouse_cerebellum and granule neurons	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
oxandrolone_homo sapiens_gpl96_gds1333	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K88590066	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50377
cellular respiration	GO Biological Process Annotations 2023	1.0	null
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878091
ventrolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25498
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44991
chromosomal region	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.100857
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A654-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242072
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSPB1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_cardiac fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.72511
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6526899__F3	PFOCR Pathway Figure Associations 2024	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904385
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38235
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055897
BRD-K55069932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14185
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.68017
GSE227592_10_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-224	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K51525251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51196
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEL	GDSC Cell Line Gene Expression Profiles	-1.0	-1.65706
GSE126463_5_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
DDX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07947
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PDGFRA_knockdown_117_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.63213
BRD-K99452971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06099
GSE218960_0_v_1_nrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04673
GTF3C4	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUBGCP2	Pathway Commons Protein-Protein Interactions	1.0	null
Vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.195
BRD-K62841603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79589
BRD-K37282009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50819
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39078
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214823,GSE214824_6_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89767_7_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE150049_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K79me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09683
BRD-K00509345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03507
Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
BRD-K47756270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15346
COX17	Pathway Commons Protein-Protein Interactions	1.0	null
heart	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.66172
PPP2CB	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.38237
GTEX-RWSA-1126-SM-2XCAZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07736
CTCF_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intermediate stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11283
MOGS	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
mitochondrial respiratory chain complex assembly	GO Biological Process Annotations 2023	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
ZNF268	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19079
Mitochondrial complex I deficiency	ClinVar Gene-Phenotype Associations 2025	1.0	null
Mitochondrion	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
ZFX-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GPN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563344
PDGFD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00670248
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2797
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868795
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10509
RKO-E6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05395
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284367
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K49338297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.3362
VC-19-YG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.44085
CLTA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K86104966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01437
19843711-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE249714_0_v_1_anxa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TULP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64638
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.31918
PMC9601604-NIHMS1841143-supplement-SuppTable-3.xlsx-shared_upregulated-Genes_upregulated_in_the_absence_of_FOXO3_in_GSCs_and_aged_NSCs_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
CCT5	Pathway Commons Protein-Protein Interactions	1.0	null
CHD7	ENCODE Transcription Factor Targets	1.0	null
H9 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.20063
BRD-K26790127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17926
CRCGN017_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15915
YD38	CCLE Cell Line Gene CNV Profiles	1.0	1.58118
TMX1	Pathway Commons Protein-Protein Interactions	1.0	null
YWHAZ	Pathway Commons Protein-Protein Interactions	1.0	null
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K01772946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20658
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.845954
Sarcoma_SARC_TCGA-DX-A3LU-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.492359
Hyperlipidemias	CTD Gene-Disease Associations	1.0	1.29256
BSX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9562
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:D16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10014
CRCGN015_MCF10A.TP53.M_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0005
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10618
HuO-3N1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.08307
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976008
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
thalamus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.954098
GSE193258,GSE193259_2_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.61368
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
outer SZ in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.992912
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BARX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9606
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.721354
FOXA1	ENCODE Transcription Factor Targets	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IQGAP3	Pathway Commons Protein-Protein Interactions	1.0	null
RND2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15844
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XGQ4-0326-SM-4GIEE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41638
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.36179
CD105+_Endothelial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.915029
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6486
aging	GAD High Level Gene-Disease Associations	1.0	0.293278
GSE188869,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78513
Mitochondrial intermembrane space protein transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.049
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38531
GSE199874_3_v_5_gabpb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CD-35-BD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243965
MIR122_OE_GDS3470_573_human_Embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
COX6C	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC	Pathway Commons Protein-Protein Interactions	1.0	null
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3577
BSG	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8807392-41375_2021_1393_MOESM2_ESM.xlsx-data_integration-YBX1_iCLIP-targets_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
INSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39571
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.274296
HEP3B217	CCLE Cell Line Gene Expression Profiles	-1.0	-1.87386
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07765
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.14048
Oxidoreductase complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.21441
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K78192025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.006
Mitochondrial nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.826
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.996311
kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09986
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-X4-A8KQ-01A-12R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55414200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2505
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NADH	DrugBank Drug Targets	1.0	null
HCC-2218	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.923372
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMPSTE24	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28982
BV173	CCLE Cell Line Gene Expression Profiles	-1.0	-3.04804
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE137914_4_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8069
MTHFD2	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38347298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43621
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.38574
MHHNB11	CCLE Cell Line Gene Expression Profiles	-1.0	-2.12546
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.067241
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EBF1	ENCODE Transcription Factor Targets	1.0	null
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SDHA	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30189
BRD-K35442564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44303
PMC3724940__F5	PFOCR Pathway Figure Associations 2023	1.0	null
GSE191037_0_v_1_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PVOW-0726-SM-2XCF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864073
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_cardiac muscle cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rosiglitazone_mus musculus_gpl8321_gds4021	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COX4I1	Pathway Commons Protein-Protein Interactions	1.0	null
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7097
BRD-A75409952_wortmannin_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17345
GSE95688_7_v_5_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.21104
Optic nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
Metabolic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04207
TIM23 mitochondrial import inner membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.54
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040536
RPS14	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:I21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49515
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3581
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3724940__F5	PFOCR Pathway Figure Associations 2024	1.0	null
GSE142210_2_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936522
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.453397
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.80588
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43514
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PMC6345883-41598_2018_37397_MOESM10_ESM.xlsx-AR_D0_VS_D14__TRANS-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.271
CTCF_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BAX	Pathway Commons Protein-Protein Interactions	1.0	null
Lateral septal nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13192
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
3568_GTF2B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503192
IDH3G	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7603-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.31381
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.234
BRD-K35085740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18219
BICR18	CCLE Cell Line Gene Expression Profiles	1.0	2.67441
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2716
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89102
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
space	GeneRIF Biological Term Annotations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HB-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2B	Pathway Commons Protein-Protein Interactions	1.0	null
CLN6	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2227	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.78567
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.537247
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K93197397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54246
GSE183327,GSE183328_1_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11051
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30629
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.18797
BRD-K97949309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12042
GTEX-VJYA-0826-SM-4KL1M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902807
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.6
primary auditory cortex (core)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.05403
ABL1_mutant_179_GSE45452	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.91378
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28037
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05449
GSE210842_3_v_1_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chromosomal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.045366
BRD-K63908919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15009
Prespliceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.582
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5126
Gigantocellular reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37936
periventricular stratum of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16784
LA-42-ER00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.663359
BRD-K63134971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22861
NEK9	Pathway Commons Protein-Protein Interactions	1.0	null
NDUFA2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5541_NDUFA8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.34098
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40603
Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ROCK_INHIBITION_GDS3944_463_mouse_Forebrain astrocytes - 12 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BC-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.81807
Lateral amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31139
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22127
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
ERG-20517297-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ts/a	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.832
VCP	Pathway Commons Protein-Protein Interactions	1.0	null
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GNB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44118
CTCF_foreskin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02299361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00944
BRD-K03467766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13267
PMC11651170-pt4c00533_si_002.pdf-118-SREBF1_SREBF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WY7C-1126-SM-3NB3A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2074
RFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19114
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.075
NV-128	DGIdb Drug Targets 2026	1.0	0.35288
NANOG-16518401-CHIP-PET-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_fibroblast of lung_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ileocecum	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
NAD	HMDB Metabolites of Enzymes	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V7-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6965
GSE144231_3_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.95724
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.955738
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.32363
lateral periretromammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.53098
Lung squamous cell carcinoma_LUSC_TCGA-18-3421-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K42943023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08696
Perturb_14279_KO_Clec4e_SRP262935	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.75242
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas	HPA Tissue Protein Expression Profiles	1.0	0.910487
BRD-K29415052_NVP-BGT226_PC3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V1D1-0626-SM-4JBHN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02563
BRD-K73149920	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06151
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21141
HELA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03863
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04495
Lung adenocarcinoma_LUAD_TCGA-44-5643-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ERBB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40963
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.59
ELK1	ENCODE Transcription Factor Targets	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Heart-cardiac muscle cell	Tabula Sapiens Gene-Cell Associations	1.0	19.6563
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCT6A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
r7 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.61804
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14048
GTEX-OXRK-0826-SM-2HMK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80445
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30002
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
respiratory chain complex i	GO Cellular Component Annotations 2015	1.0	null
GTEX-XXEK-0926-SM-4BRWH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46257
vitamin e_mus musculus_gpl1261_gse42813	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3419
i-AAA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.629
intermediate stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.76796
RPL15	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BE-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37931
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WPMY-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.578
H3K36me3_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE196540,GSE196542_2_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral septal nucleus, intermediate part, periventricular	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56527
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2217
doxorubicin_homo sapiens_gpl10558_gse42531	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SYK_druginhibition_287_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.28761
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.416
iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.567
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Skeletal muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.195
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.226667
GSE119345_0_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KIR2DL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00479535
Motor nucleus of trigeminal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10683
17660535-TableS4b	GeneSigDB Published Gene Signatures	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.003
U-698-M	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.26309
BRD-K97595801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33131
BRD-K17303020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07418
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17002
Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
catalytic complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.003079
GSE139239_3_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864144
GSE227634,GSE228381_0_v_7_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1395	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.909381
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SYK_druginhibition_282_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.62326
EFTUD2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K76723780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.721
GTF2I	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11462941-CAS-115-2947-s001.pdf-40-RFX3_RFX3	Rummagene Transcription Factor Associations 2026	1.0	null
KAT2B	ENCODE Transcription Factor Targets	1.0	null
KA-75-LP02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483229
GSE138019_4_v_5_nudt12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.525
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6473
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XPVG-0326-SM-4B653	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840305
U266B1	CCLE Cell Line Gene CNV Profiles	1.0	1.37458
ASS1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9732
GTEX-XOT4-1426-SM-4B65T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899986
Mitochondrial proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.14
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A4CL-01A-41R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.75117
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
RANBP1	Pathway Commons Protein-Protein Interactions	1.0	null
CEPT1	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.108
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.02542
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Ileocecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.129
REST_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC-202	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.909934
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28007
CTCF_GM12875_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20236423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62796
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.20211
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Squamous cell carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
DA-27-BW40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.398495
HELLS	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4409
intermediate stratum of Hb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02981
EIF3B	Pathway Commons Protein-Protein Interactions	1.0	null
DB-40-GN91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202998
FAR1	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-IS-A3K6-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRPM7_defectivemutant_306_GSE23102	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.19687
Subparafascicular nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13336
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4223
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1652
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.883321
Central amygdalar nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03752
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852124
BRCA1	ENCODE Transcription Factor Targets	1.0	null
BRD-A20248179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00018
MNX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8052
SKCO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42564
oxidoreductase complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.009517
nadh dehydrogenase (quinone) activity	GO Molecular Function Annotations 2015	1.0	null
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14048
heart	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.43654
GTEX-NPJ8-0426-SM-2HMK6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68995
limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.953723
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
LHX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5582
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72917
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3031
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.53151
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
gracile nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.905732
HELA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35814
mitochondrial respiratory chain complex i	GO Cellular Component Annotations 2015	1.0	null
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.7149
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98732
BICR22	CCLE Cell Line Gene CNV Profiles	1.0	1.45146
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN1_n_EN1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K79me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
conn's syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.794181
Mitochondrial intermembrane space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.575
inner SZ in dorsomedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.941893
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC25A3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K61440521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00314
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16356
Quadriceps	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.07
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.6366
Cranial nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K33260002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02537
RARS	Pathway Commons Protein-Protein Interactions	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
WDR6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92950328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91379
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NADH dehydrogenase complex assembly	GO Biological Process Annotations 2023	1.0	null
BRD-K24220535	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05273
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
increased body weight	GWASdb SNP-Phenotype Associations	1.0	0.899912
LARS	Pathway Commons Protein-Protein Interactions	1.0	null
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.9763
HCC2157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24761
CRCGN017_MCF10A.TP53.M_24H:N10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33703
GSE207787_1_v_4_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.287885
PMC12021535-CPH4-15-e70011-s001.xlsx-S9-KLF2_KLF2	Rummagene Transcription Factor Associations 2026	1.0	null
Dihydrolipoyl dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.884
CTCF_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-QESD-0526-SM-2I5G5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34083
GSE216147_0_v_1_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6045
PMC6352376__F4	PFOCR Pathway Figure Associations 2024	1.0	null
periventricular stratum of VTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61567
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.54123
RPS6KA3_knockout_73_GSE22137	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.12583
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.78145
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947149
Nutritional deficiency, NEC_Skeletal Myocyte_GSE1776	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.73745
Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A6I9-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-7140-01A-41R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
germinal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.67658
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
organelle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.062755
GTEX-VUSG-0726-SM-3GIK1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26491
A549_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127874
CCL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14623
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LHX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8392
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910932
lung	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-0.878234
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4480	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.882409
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MIB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.166
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.51911
PMC12081695-41598_2025_1907_MOESM1_ESM.pdf-3-BBX_BBX	Rummagene Transcription Factor Associations 2026	1.0	null
Mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.547
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NFYA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsal motor nucleus of the vagus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.21177
Organellar ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.902
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-10_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
paclitaxel_rattus norvegicus_gpl890_gse5337	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.596075
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999532
NCIH1436	CCLE Cell Line Gene Expression Profiles	1.0	1.59832
FKBP8	Pathway Commons Protein-Protein Interactions	1.0	null
cytochrome-c oxidase deficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.212
Male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LIVF001-002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.90391
Reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-590-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
H3K4me1_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.91721
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61027868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61611
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
outer SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.71708
GFI1B	ChEA Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1A7-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NDUFB6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535714
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.528491
Thalamus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316006
7426_RPF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.572323
RGP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14124
BRD-K94049419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92146
H3K27ac_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SHANK3_KD_GDS4759_338_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM12868_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCT4-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5959
prolonged RR interval	IMPC Knockout Mouse Phenotypes	1.0	null
RL7	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.74523
TTC27	Pathway Commons Protein-Protein Interactions	1.0	null
KNS-62	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.86627
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.29634
GSE215351,GSE215794_4_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4736
NUDT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33499
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A512-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD4_Memory_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.84664
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9183
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.951863
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MARS	Pathway Commons Protein-Protein Interactions	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2326
esophagus	HPA Tissue Protein Expression Profiles	1.0	0.910487
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SZ in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17124
mifepristone_homo sapiens_gpl6947_gse39654	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
overnutrition	GWASdb SNP-Disease Associations	1.0	0.474846
BRD-K21910317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02044
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TE14	CCLE Cell Line Gene CNV Profiles	1.0	1.48373
19643001-Additional-File2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WK11-0626-SM-3NMAV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56054
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.61854
BRD-K41498330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72907
BRD-K02529187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24804
Piriform-amygdalar area, polymorph layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85072
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.682553
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
KY821	GDSC Cell Line Gene Expression Profiles	-1.0	-2.1196
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845255
BRD-K64970964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8775
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.976491
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60576
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
ALYREF	Pathway Commons Protein-Protein Interactions	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051605
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.43325
OVTOKO	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34207
BRD-K62085719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0833
BRD-K02625776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8271
BRD-K22384464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37548
GTEX-T8EM-0326-SM-3DB7F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825583
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.62013
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16792
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47678
PLEKHF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.203
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H3-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46339
BRD-K35429158	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06522
PPP1CA	Pathway Commons Protein-Protein Interactions	1.0	null
drug-related genes	GAD Gene-Disease Associations	1.0	null
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.584805
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.74789
Organelle envelope lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SERINC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4582
STIP1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.050755
PPP2R5C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K74314059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15491
FE-64-KC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.906282
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.894946
STAT3-1855785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.4213
XPOT	Pathway Commons Protein-Protein Interactions	1.0	null
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-CA-04-2009(H1N1)_6Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.52426
BRD-K92974694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69306
BRD-K08867654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55857
MAGED2	Pathway Commons Protein-Protein Interactions	1.0	null
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.365318
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE215351,GSE215794_4_v_0_kdm8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RFT1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6794_PRPF38A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506637
mitochondrial part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.341529
HMGN3	ENCODE Transcription Factor Targets	1.0	null
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63386
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1899
PMC11321995-41556_2024_1460_MOESM2_ESM.xlsx-Supplementary_Table_9-Supplementary_Table_9_Unique_genes_with_exons_significantly_correlated_with_OTX2_expression_in_Group_3_and_Group_4_MB_tumors_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
PGC-1alpha_Deficiency_GDS4904_311_mouse_Aged gastrocnemius muscle - 24 months	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
DOK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00459693
Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.907249
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22586
CREB1	ENCODE Transcription Factor Targets	1.0	null
GTEX-T6MN-0926-SM-32PLX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.46397
GOLGA6L9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26021
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.19006
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7252
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.44101
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8458
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.69459
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.15039
NRF1	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-K1-A3PO-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC3419980-leu201249x6.xls-RUNX1-DHS-1000bp-Unnamed_0_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table2_ChinaMAP_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.27068
Ovum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.715
CTNNBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30021
mitochondrial inner membrane	GO Cellular Component Annotations 2023	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.722372
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mitochondrial part	GO Cellular Component Annotations 2015	1.0	null
CD177	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00565831
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CHD2	ENCODE Transcription Factor Targets	1.0	null
Nucleus of the solitary tract, commissural part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.03367
GTF3C6	Pathway Commons Protein-Protein Interactions	1.0	null
FLI1_01_14	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59874
SDF2L1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K25363217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34928
TUBB4A	Pathway Commons Protein-Protein Interactions	1.0	null
TEAD4	ENCODE Transcription Factor Targets	1.0	null
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3235
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPM-0326-SM-33HCA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51449
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE217105_0_v_1_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Complex I biogenesis	Reactome Pathways 2024	1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CPEB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21371
E2F4	ENCODE Transcription Factor Targets	1.0	null
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98321
NDUFA7	Pathway Commons Protein-Protein Interactions	1.0	null
Central medial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56119
PMC5404927-elife-24463-supp1.xlsx-1b_ERM_proteome-Gene_names_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.00807
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.890568
B4GALT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495465
OVCAR4	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.32973
CHCH	InterPro Predicted Protein Domain Annotations	1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UMRC2	CCLE Cell Line Gene Expression Profiles	1.0	1.66471
BRD-K56285711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25094
PMC10721014-pone.0295542.s010.xlsx-Table_S9-Table_S9_Spearman_s_correlation_between_the_expression_levels_of_ESRRA_and_OXPHOS_subunits_genes_ESRRA	Rummagene Transcription Factor Associations 2026	1.0	null
FOS	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86748
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.971346
BRD-K49490091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5188
CAD	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892882
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Electron transport chain OXPHOS system in mitochondria	WikiPathways Pathways 2024	1.0	null
cell property	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075375
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.72608
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
LHX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5171
DDX20	Pathway Commons Protein-Protein Interactions	1.0	null
cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SR786	CCLE Cell Line Gene Expression Profiles	-1.0	-1.65349
16081686-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8127
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.606
Pacemaker cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.751
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43403
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5890-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA2	ENCODE Transcription Factor Targets	1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233801
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
19965622-TableS2a	GeneSigDB Published Gene Signatures	1.0	null
H4K5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.997669
GSE193999,GSE194000_4_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00349
PMC6424098-mmc5.xlsx-CEBP_Binder-Gene_names_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XBED-0226-SM-47JY8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00564
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.18326
A549_ENMD-2076 L-Tartaric acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126984
TCF24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30748
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE71385_1_v_2_cdk8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
WDR77	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.81815
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
TP53INP2_OE_GDS5054_545_mouse_skeletal muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
IRS4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
mitochondrial envelope	GO Cellular Component Annotations 2023	1.0	null
EN2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0678
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KB-78-BE93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319172
Lung squamous cell carcinoma_LUSC_TCGA-77-7335-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.6094
BRD-K41412255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45681
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GATAD2A	Pathway Commons Protein-Protein Interactions	1.0	null
LM3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
PMC9010637-mmc6.xlsx-5D-Figure_5D_Gene_Expression_Zhou_et_al_Application_of_SP3-Rox_to_identify_redox_changes_during_T_cell_maturation_SP3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2C_MEF2C	Rummagene Transcription Factor Associations 2026	1.0	null
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14196
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_352_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11481
HNRNPDL	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K51385533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38154
SKIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03187
CTCF_fibroblast of lung_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ALG1	Pathway Commons Protein-Protein Interactions	1.0	null
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220595
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NAP1L1	Pathway Commons Protein-Protein Interactions	1.0	null
U-118-MG	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.74256
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.519
COQ6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487383
CRCGN016_MCF10A.TP53.M_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9073
TUBA1B	Pathway Commons Protein-Protein Interactions	1.0	null
SSR1	Pathway Commons Protein-Protein Interactions	1.0	null
protein complex binding	GO Molecular Function Annotations 2015	1.0	null
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.494506
vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.533987
NCI-H1648	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.38182
BRD-K74870161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29002
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08867
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01622
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08915
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
IPO4	Pathway Commons Protein-Protein Interactions	1.0	null
Piriform-amygdalar area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36611
SB-92-FF15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298594
RCN2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC6683136-41598_2019_47363_MOESM5_ESM.xlsx-GENE_SET-Negative_correlation_of_ZEB1_and_other_genes_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.184
CSTB_KO_GDS5090_198_mouse_Cerebellum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877909
Lung adenocarcinoma_LUAD_TCGA-64-5781-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GRK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00548673
POLR2H	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6597-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.833173
STT3A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.025418
fallopian tube	HPA Tissue Protein Expression Profiles	1.0	0.910487
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2234
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
respiratory chain complex i	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
NADH dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.714
A-CA-04-2009(H1N1)_12Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.49227
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18904
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9805
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.42988
MAX	ENCODE Transcription Factor Targets	1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35682
GSE212312_2_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
POU2F2	ENCODE Transcription Factor Targets	1.0	null
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.862476
CRCGN015_MCF10A.TP53.M_24H:F09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18395
19843711-TableS2	GeneSigDB Published Gene Signatures	1.0	null
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSE1L	Pathway Commons Protein-Protein Interactions	1.0	null
STAT3-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SERBP1	Pathway Commons Protein-Protein Interactions	1.0	null
S100A11	Pathway Commons Protein-Protein Interactions	1.0	null
SNU1214	CCLE Cell Line Gene Expression Profiles	1.0	1.38215
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-43-ZC52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226526
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35814
GSE151782_3_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.37874
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6625
MAT2A	Pathway Commons Protein-Protein Interactions	1.0	null
Testis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
CORL24	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44378
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
IMPDH2	Pathway Commons Protein-Protein Interactions	1.0	null
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251864
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01494
LMAN2	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.995
STAT2	Pathway Commons Protein-Protein Interactions	1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275222
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0421
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9680_UTP14A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.678759
GSE201239_0_v_7_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.808522
TBP	ENCODE Transcription Factor Targets	1.0	null
HADHA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00822912
ChIP_PRDM14_21183938	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
localized	GeneRIF Biological Term Annotations	1.0	null
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28483
3-methylglutaconic aciduria with cataracts, neurologic involvement and neutropenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MN-9D cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.515
rosiglitazone_mus musculus_gpl1261_diabetes_gds4036	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.17724
CDIPT	Pathway Commons Protein-Protein Interactions	1.0	null
BICR31	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.00501
mitochondrial electron transport, NADH to ubiquinone	GO Biological Process Annotations 2025	1.0	null
CRCGN009_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25692
NFKB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52486
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chemical carcinogenesis - reactive oxygen species	KEGG Pathways 2026	1.0	null
CYR61	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24283
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.03457
MDAMB436	CCLE Cell Line Gene CNV Profiles	1.0	1.96257
NFYA	ENCODE Transcription Factor Targets	1.0	null
Atherosclerosis	CTD Gene-Disease Associations	1.0	1.17399
GTEX-X3Y1-0426-SM-3P5Z4	GTEx Tissue Sample Gene Expression Profiles	1.0	2.06163
GSE212486,GSE212488_0_v_1_gata4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29584
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0296
XPO5	Pathway Commons Protein-Protein Interactions	1.0	null
RA-27-ST16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.35212
mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
diencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VCAP	Achilles Cell Line Gene Essentiality Profiles	1.0	2.33007
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6833
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RAI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16733
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991935
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963927
GSE93309_2_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC25A13	Pathway Commons Protein-Protein Interactions	1.0	null
DA-81-VY50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238231
Uterine leiomyoma_Uterus_GSE2724	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.49762
VDAC2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RNGTT	Pathway Commons Protein-Protein Interactions	1.0	null
TOMM70A	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K34501072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98815
TAMH cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.902
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.947075
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325481
BRD-K08205503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0099
GTEX-SIU7-0426-SM-2XCDX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41991
RPS28	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K57349002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28977
GSE114258_1_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.66239
BRD-K63330804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26371
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.841868
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3254
GTEX-PX3G-0326-SM-2I3EO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49922
Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HT-01A-12R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
Parasolitary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35366
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.990039
TOP2A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918544
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U2SURP	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41044903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07684
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.35945
GSE231648_4_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXB7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4293
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SRF_SRF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.991883
COX5A	Pathway Commons Protein-Protein Interactions	1.0	null
abnormal lens morphology	MGI Mouse Phenotype Associations 2023	1.0	null
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40488
BB-20-UU03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256045
BRD-U02532950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49328
CRCGN016_MCF10A.TP53.M_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51664
ventral reuniens nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.16225
GTEX-XUW1-0726-SM-4BOP5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849554
EP400	Pathway Commons Protein-Protein Interactions	1.0	null
nephronophthisis-like nephropathy 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.073
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839201
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.91037
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01082
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83586
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.00575
hsa-miR-569	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85882
r10 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.90376
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y0-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.5868
GTEX-NFK9-0926-SM-2HMJU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26336
NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8	InterPro Predicted Protein Domain Annotations	1.0	null
ABHD12	Pathway Commons Protein-Protein Interactions	1.0	null
Electron Transport Chain(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-8195-01A-31R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mitochondrial intermembrane space	GO Cellular Component Annotations 2023	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K45978015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4938
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
S0-EE-WH3B_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217602
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03001
MKN1_STOMACH	CCLE Cell Line Proteomics	1.0	3.27561
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RP58	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12522
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.084
BRD-K84541452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08364
RPL35	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849557
GSE212299_3_v_0_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.870236
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K33606963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67367
PMC7657662__F2	PFOCR Pathway Figure Associations 2023	1.0	null
EIF4G1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16256
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary coenzyme Q10 deficiency 8	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.333
BRD-K47467075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00027
IZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14673
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4409
PMC11665843-SYB2-18-218-s001.pdf-132-TCF12_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54233340_Dorsomorphin dihydrochloride_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE213632_1_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXC8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2657
intermediate stratum of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2347
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049908
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94618
BT474	CCLE Cell Line Gene CNV Profiles	1.0	2.18148
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K28579021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06223
dorsal motor nucleus of the vagus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.35342
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74908
BRD-K31530457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02628
BRD3OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32289
H3K36me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Memory Disorders	CTD Gene-Disease Associations	1.0	1.23616
Perturb_17376_KD_E2f1_SRP190223	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.05832
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S23_LF_C1_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
EEF1G	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
r2 part of dorsal parvicellular reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28688
rectum	HPA Tissue Protein Expression Profiles	1.0	0.910487
BRD-K48900723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58388
mitochondrial intermembrane space	GO Cellular Component Annotations 2015	1.0	null
UQCRC1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.74861
BT474	CCLE Cell Line Gene Expression Profiles	1.0	1.45687
RANBP9	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158081
GSE157557,GSE157559_1_v_0_parp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6972-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NDUFA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61979
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864716
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1673
MSH3	Pathway Commons Protein-Protein Interactions	1.0	null
Posterior parietal association areas, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3311
CD4_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.29441
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.86297
RPL5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K38617061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0984
EMD	Pathway Commons Protein-Protein Interactions	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.986627
BRD-K80336250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45948
BRD-A09961470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85409
BRD-A94366206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23949
RPLP0	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.972765
TRAFD1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829305
CTCF_epithelial cell of esophagus_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.59186
PANC 04.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23858
COR-L105	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	3.05453
IGR39	CCLE Cell Line Gene CNV Profiles	1.0	1.49625
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K02334683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35087
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049821
SAP30	ENCODE Transcription Factor Targets	1.0	null
BRD-K11874023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89796
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A622-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7794
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EE-03-SG02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20171
aerobic respiration	GO Biological Process Annotations 2023	1.0	null
Vermiform appendix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.129
mitochondrial envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.278509
BRD-K54964687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09322
LARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39588
TRRAP	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OXRO-1926-SM-2S1O3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831555
RPS6	Pathway Commons Protein-Protein Interactions	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
Female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
BRD-K19965080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46763
mantle zone of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02622
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01776
respiratory electron transport chain	GO Biological Process Annotations 2015	1.0	null
PSMB3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07636
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OMC-1	GDSC Cell Line Gene Expression Profiles	-1.0	-2.06429
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CA-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM06990_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
HCC2157	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.28054
proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.508
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-1.31623
ECT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15978
PTPN14	Pathway Commons Protein-Protein Interactions	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
BRD-K40804250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35553
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6459_KD_LKB1_SRP094725	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.45831
CTCF_fibroblast of mammary gland_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCDC124	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K26481999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09536
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3135
NDUFS2	Pathway Commons Protein-Protein Interactions	1.0	null
UBR2	Pathway Commons Protein-Protein Interactions	1.0	null
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.065
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
BRD-K01467488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51256
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TCP1	Pathway Commons Protein-Protein Interactions	1.0	null
chitin-based extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.041
AASS	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SA1-27219007-CHIP-SEQ-ERYTHROID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ERLIN2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K37956279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53541
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MU-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K41993678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31816
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24819
FAM168A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06408
MSH2	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-3	GDSC Cell Line Gene Expression Profiles	-1.0	-3.12997
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12189
Muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.195
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.900459
ADNP_Deficiency - NULL MUTATION_GDS2540_692_mouse_E9 embryos - Homozygous mutant	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
DNAJB6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A92490200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60103
TCEB1	Pathway Commons Protein-Protein Interactions	1.0	null
ATP1B3	Pathway Commons Protein-Protein Interactions	1.0	null
Muscular Dystrophy_Muscle - Striated (Skeletal) (MMHCC)_GSE2507	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.45092
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.955738
Parataenial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9111
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02708799_GSK-1059615_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.061
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12291
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26771
CUX1	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cytosolic proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.594
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14745
muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.89489
9886_XAB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19958
Lung squamous cell carcinoma_LUSC_TCGA-33-A5GW-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.951739
NANOG-16518401-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04785
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8078
The citric acid (TCA) cycle and respiratory electron transport	Reactome Pathways 2014	1.0	null
Left atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.845
CTCF_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A67788537_Salermide_PC3_24.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3440-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8144-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.213283
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IGF2BP1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_7552_OE_IL1RN_SRP300901	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.67017
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6948-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.0457
Ubiquinone-2	HMDB Metabolites of Enzymes	1.0	null
CRCGN016_MCF10A.TP53.M_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.78723
THOC2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02561
GSE62292,GSE62295_2_v_0_col4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
decreased circulating sodium level	MGI Mouse Phenotype Associations 2023	1.0	null
HOXA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1949
SKMEL1	CCLE Cell Line Gene CNV Profiles	1.0	1.58379
BRD-K49307935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.76953
ROS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.756
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.13816
BRD-K23825243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.242
BRD-K75330923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10358
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.94363
RPL22	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K82863660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48305
TRMT1L	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5259-01A-31R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148200_1_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_9_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11156
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K71944493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08179
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.90432
PHF8	ENCODE Transcription Factor Targets	1.0	null
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.032
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04873
IA-65-QX27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274502
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3079
BRD-K14417813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05582
E2F3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52002
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857619
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPP6R3	Pathway Commons Protein-Protein Interactions	1.0	null
Anteromedial visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.68226
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18904
BRD-K41853443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21617
Mitochondrial ribonuclease P complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.937
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE101112_6_v_4_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842038
HOXB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.083
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.449102
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058417
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K23432132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49423
K562_SL-327_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188276
GSE184902_3_v_0_adipor1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mitochondrial ATP synthesis coupled electron transport	GO Biological Process Annotations 2023	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDVN-0326-SM-2I3FS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07741
GTEX-PSDG-1126-SM-2S1ON	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91993
BRD-K93335719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06788
BRD-K91654532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.87069
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9210_TPP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.608894
DCXR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00287
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EM-2	GDSC Cell Line Gene Expression Profiles	-1.0	-2.11845
Rhomboid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.5339
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-WZTO-1326-SM-3NM8X	GTEx Tissue Sample Gene Expression Profiles	1.0	2.8486
GSE247862,GSE247863_0_v_1_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAB1B	Pathway Commons Protein-Protein Interactions	1.0	null
TIMMDC1	Pathway Commons Protein-Protein Interactions	1.0	null
BB30-HNC	GDSC Cell Line Gene Expression Profiles	1.0	1.57678
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
RPL17	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4165364-13059_2014_406_MOESM5_ESM.xls-Supp_Dataset_1-SUPPLEMENTARY_DATASET_1_AML3_AzaC_SigDiff_1147_Note_to_reviewers_-_view_these_files_as_xls_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65634
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27067
CORL311	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33219
CHCHD6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NUP153	Pathway Commons Protein-Protein Interactions	1.0	null
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.36193
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3573
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38235
Essential Thrombocytemia_Thrombocyte_GSE2006	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.83388
oxidoreductase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37174
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.2803
MAPK14_knockout_14_GDS2693	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.22606
PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFON-0226-SM-3GIKR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09302
BRD-K46561246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33373
basomedial amygdaloid nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02673
YY1	ChEA Transcription Factor Targets	1.0	null
NRF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDUFV3	Pathway Commons Protein-Protein Interactions	1.0	null
Endocuticle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.581
TE5	CCLE Cell Line Gene Expression Profiles	1.0	2.4637
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.10314
NIPSNAP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE248858_6_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267354
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.89482
Electron Transport Chain(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.74934
KARPAS-231	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.81918
MEF2A_KD_GDS4759_340_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
AP5Z1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53198
7929_SIRT7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.515835
CRCGN015_MCF10A_48H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3928
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K44403120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20693
muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.081194
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZFX-18555785-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NFYB	ENCODE Transcription Factor Targets	1.0	null
Dehydration_Hypothalamus_GSE3125	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.71531
Death	CTD Gene-Disease Associations	1.0	1.10069
BRD-A94740628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40987
HK-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
SNRPF	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A3MI-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
T-REx 293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
Dorsal column nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02398
BCR	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTSF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00589993
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K86293440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23028
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.482247
GAK	GDSC Cell Line Gene Expression Profiles	1.0	1.76494
COLO-678	GDSC Cell Line Gene Expression Profiles	-1.0	-1.77274
Perturb_3921_KD_VPS37A/VPS37B/VPS37C_SRP266781	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.8235
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34663
obesity	GWASdb SNP-Disease Associations	1.0	1.02476
HOXB4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4421
Atrophy	CTD Gene-Disease Associations	1.0	1.13827
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14545
CTCF_fibroblast of the aortic adventitia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
888	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.985185
TXN	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K83049611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.006
CTCF_fibroblast of pulmonary artery_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.833806
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
2812_F8A1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.648698
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6197
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.513081
Mitochondrial complex I assembly model OXPHOS system	WikiPathways Pathways 2024	1.0	null
organelle membrane	GO Cellular Component Annotations 2015	1.0	null
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of body weight	GWASdb SNP-Phenotype Associations	1.0	0.360941
BRD-K62612761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24915
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71437
BRD-K58323923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46082
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mitochondrial chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.826
aging/ telomere length	GAD Gene-Disease Associations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LB-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2089
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.51238
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNCA	Hub Proteins Protein-Protein Interactions	1.0	null
NBPF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05447
island of Calleja major	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11416
BRD-K52731672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76566
GSE158456_1_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-95-7947-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2558
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_Caco-2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AKAP8	Pathway Commons Protein-Protein Interactions	1.0	null
EIF2S1	Pathway Commons Protein-Protein Interactions	1.0	null
10040_ZCCHC9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.537199
KPNA2	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
DNAJA2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11481
RAD21_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.25994
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAX	Pathway Commons Protein-Protein Interactions	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UF-27-HS98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256135
BRD-K67702605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53146
CRCGN017_MCF10A.TP53.M_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47898
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.137
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15964
MCF-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00132
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JK-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5161
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
TIMM50	Pathway Commons Protein-Protein Interactions	1.0	null
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60387
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
c-MYC_KD_GDS2526_110_human_BT-474 BREAST CANCER cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-A84867566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77123
CHD4	Pathway Commons Protein-Protein Interactions	1.0	null
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.974207
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.91885
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864381
2-BFI	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73194
GSE57871_6_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
chemdependency	GAD High Level Gene-Disease Associations	1.0	0.293278
periventricular stratum of APal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31043
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925734
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71385
SLC2A1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.063
cx9c	GeneRIF Biological Term Annotations	1.0	null
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18233
Lung adenocarcinoma_LUAD_TCGA-64-5778-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ethmoid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00503
proton motive force-driven ATP synthesis	GO Biological Process Annotations 2025	1.0	null
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormal retina blood vessel morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99211
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVMANA	CCLE Cell Line Gene CNV Profiles	1.0	1.77057
BRD-K10146653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42269
NDUFS7	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE137653_4_v_0_siglecf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318691
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933809
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.679
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-0326-SM-2HMJO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDCA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2611
temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
7487_RPP14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.595195
HOP-92	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05687
GTEX-OIZH-0326-SM-2HMKC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.27937
MM77	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39916
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47981
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.720112
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
Secondary motor area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.63491
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE165647_5_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEC6_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	5.33009
BECN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06659
Organellar small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.462
CRCGN016_MCF10A.TP53.M_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00906
GTEX-XLM4-2026-SM-4AT4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30433
CTCF_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5811_NRF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.810432
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TRIM24_knockout_298_GDS3087	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.63275
PSMB4	Pathway Commons Protein-Protein Interactions	1.0	null
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.518
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
HM13	Pathway Commons Protein-Protein Interactions	1.0	null
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30795
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12864_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPP30	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02705
GTEx AdiposeTissue 20-29 vs 30-39	GTEx Tissue-Specific Aging Signatures	-1.0	-6.23417
Cecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.129
TE15	Achilles Cell Line Gene Essentiality Profiles	1.0	1.6734
Alzheimer disease	KEGG Pathways 2026	1.0	null
mitochondrial membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.538649
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.23
ME-180	GDSC Cell Line Gene Expression Profiles	1.0	1.80977
NRF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NKX6-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9396
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU719_STOMACH	CCLE Cell Line Proteomics	1.0	2.34756
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.2097
pretectal nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.914239
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01156
Perturb_13951_KD_ASCL1_SRP201348	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
EBF1-22473956-BONE-MARROW-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24414
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IFT22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33252
BMI1-19503595-MEFSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.65576
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.19119
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU6F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9198
layer 1 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17198
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.728382
PCNA	Pathway Commons Protein-Protein Interactions	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046444
BRD-K00265832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33114
GSE80537_3_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Oral mucosa	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.547
HOXA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3732
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10449
BRD-K72588970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50131
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.805
hsa-miR-522	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
GSE242199_9_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TD-01A-51R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATP2A2	Pathway Commons Protein-Protein Interactions	1.0	null
RAB14	Pathway Commons Protein-Protein Interactions	1.0	null
FOXP2-21765815-NEURO2A-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.44366
PSMA2	Pathway Commons Protein-Protein Interactions	1.0	null
CELF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593838
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46F-01A-31R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Crizotinib_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0138621
GSE110178_1_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal lens morphology	IMPC Knockout Mouse Phenotypes	1.0	null
SAM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.803
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.5758
BHT101	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53706
ME-180	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331196
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17342
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846335
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table8_gnomAD_AFR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
PANC0213	CCLE Cell Line Gene CNV Profiles	1.0	1.33448
RAD23A	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65D-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU601	CCLE Cell Line Gene Expression Profiles	-1.0	-2.29401
PMC7000220-elife-50163-fig3-data1.xlsx-genes_SOM_xls-gene_symbol_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-N7MS-0826-SM-2HML4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60901
BRD-K28995832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34145
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67656
GTEX-X5EB-0626-SM-46MVQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15016
GSE185944_5_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042019
MARCO	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623109
Weight Loss	CTD Gene-Disease Associations	1.0	1.43455
PSMD4	Pathway Commons Protein-Protein Interactions	1.0	null
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_2193_KO_Mapk14_SRP340118	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.30776
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rifaximin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
EVX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6793
SRPRB	Pathway Commons Protein-Protein Interactions	1.0	null
SNU1214	CCLE Cell Line Gene CNV Profiles	1.0	2.10974
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
IRX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31914
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01477
ATP5F1	Pathway Commons Protein-Protein Interactions	1.0	null
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.841993
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A39407481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16899
GSE183271_2_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCC70	GDSC Cell Line Gene Expression Profiles	-1.0	-1.56604
BRD-K20043699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41315
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XV7Q-0726-SM-4BRV6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27385
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
c-MYC_KD_GDS2526_113_human_MDA-MB-231 BREAST CANCER cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
COLO-792	GDSC Cell Line Gene Expression Profiles	1.0	1.58248
cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.161139
BRD-K23366960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12997
GSE149264,GSE149267_2_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.378897
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07511
IARS	Pathway Commons Protein-Protein Interactions	1.0	null
Leigh disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.216
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.617671
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	1.0	0.957194
inferolateral temporal cortex (area TEv, area 20)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.829005
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Polycystic Ovary Syndrome_Adipose tissue_GSE5090	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.42833
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.032
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4802
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TD-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
mitochondrial myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.976323
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91192
GTEX-U3ZN-1426-SM-3DB87	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71638
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.865756
GTEX-PWCY-0526-SM-2I3ER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35129
2132_DDX56_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.530191
BRD-K28296557_Akt inhibitor IV_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.978844
RPL18	Pathway Commons Protein-Protein Interactions	1.0	null
TMEM33	Pathway Commons Protein-Protein Interactions	1.0	null
BZW1	Pathway Commons Protein-Protein Interactions	1.0	null
REST	ChEA Transcription Factor Targets	1.0	null
A549_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168423
EIF3I	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mitochondrion	LOCATE Curated Protein Localization Annotations	1.0	null
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.925744
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03729
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057897
ACTL6A	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07957
CTCF_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885565
GSE242199_2_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PSMC5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K77548697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.75541
PMC9691391-7945884.f3.pdf-165-ENSG00000167981_ZNF597	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K71339292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06356
NALM1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70694
RPN1	Pathway Commons Protein-Protein Interactions	1.0	null
Nodulus (X)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15666
BRD-K78202004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24036
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F0-01A-12R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60861976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03915
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K79090631_CGP-60474_HCC515_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NRF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4397-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10946
CLPB	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA4L	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrial membrane	GO Cellular Component Annotations 2023	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Oxidative phosphorylation	WikiPathways Pathways 2024	1.0	null
LETM1	Pathway Commons Protein-Protein Interactions	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7353-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K70851916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4554
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3-18555785-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF665	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55593
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8092
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.92224
mitochondrial electron transport, nadh to ubiquinone	GO Biological Process Annotations 2015	1.0	null
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33445
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09568
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.68561
BRD-K97929312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17358
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01541
MYOD1_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23578
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.904884
bridges	GeneRIF Biological Term Annotations	1.0	null
mammillary part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64082
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918747
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846335
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CO-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.856648
Brain Lower Grade Glioma_LGG_TCGA-DU-5870-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_WI38_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Down Syndrome_CNS - Brain - Cerebellum (MMHCC)_GSE1611	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.84909
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1569	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.68561
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CALU3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.77667
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Respiratory chain complex I, mitochondrial	CORUM Protein Complexes	1.0	null
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NDUFA5	Pathway Commons Protein-Protein Interactions	1.0	null
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WH7G-0326-SM-3NMBH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26323
gallbladder	HPA Tissue Protein Expression Profiles	1.0	0.910487
TIMM10	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC3A2	Pathway Commons Protein-Protein Interactions	1.0	null
parasubthalamic nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06156
Perturb_3924_KD_VPS37B/VPS37C_SRP266781	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.2849
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10679653-mmc2.xlsx-ISL1_KO_Markers_L-Unnamed_0_ISL1	Rummagene Transcription Factor Associations 2026	1.0	null
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.869278
r7 part of the basointermediate reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.31704
SLC25A18	Pathway Commons Protein-Protein Interactions	1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2956-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2622_EMG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.612588
SK-MEL-28	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.84063
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6822
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61604
ETFA	Pathway Commons Protein-Protein Interactions	1.0	null
GSE184902_3_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RFC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3513
Thap11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.6076
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IRAK1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289178
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932626
CAL-33	GDSC Cell Line Gene Expression Profiles	1.0	2.85859
RPLP2	Pathway Commons Protein-Protein Interactions	1.0	null
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5647
striatum_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.829005
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052469
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.22932
SCRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30671
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.19747
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.198
superficial stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17712
rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.37223
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203158_0_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
central medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17458
GSE180800,GSE180801_0_v_5_tex10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-X3Y1-0226-SM-3P5Z5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57026
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14336
NDUFB11	Pathway Commons Protein-Protein Interactions	1.0	null
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052565
BRD-K75672292	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3788
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.6489
QPCT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12602
submedius thalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.67501
Liver Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.05237
TCF12	ENCODE Transcription Factor Targets	1.0	null
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855899
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.2177
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.555132
CTCF_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02989
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.5403
FAF2	Pathway Commons Protein-Protein Interactions	1.0	null
STUB1	Pathway Commons Protein-Protein Interactions	1.0	null
precentral gyrus, left, inferior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.926083
FBXW8	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.77897
TIMM13	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_fibroblast of foreskin _hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.11217
AtrioventricularNode	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.2229
localization	GeneRIF Biological Term Annotations	1.0	null
subthalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37412
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826128
XRN1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66645
SKMEL24	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43722
TOMM40L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07559
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18105
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.884737
r7 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01599
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cisplatin_homo sapiens_gpl6883_gse47980	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_4_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5806898-pbio.2004411.s003.xlsx-MR_plot_data-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
three	GeneRIF Biological Term Annotations	1.0	null
UBE2C	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158320,GSE183351_2_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
endocrine organ benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.454093
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Supramammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54723
BRD-K67353973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7623
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58816
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DD-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04049
Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072679
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table7_gnomAD_AMR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25933460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89061
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE156708_1_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
4384_KIF20A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0076
RPL23	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.45445
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68611
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTF3C2	Pathway Commons Protein-Protein Interactions	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RTLS-0826-SM-2TF5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02573
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01082
mantle zone of PalSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27112
TOP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE85880,GSE85881_0_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.348697
SIRT6	ENCODE Transcription Factor Targets	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.15448
BRD-K53281329_SYK-inhibitor_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841458
single-organism process	GO Biological Process Annotations 2015	1.0	null
Diabetes Mellitus	CTD Gene-Disease Associations	1.0	1.10388
RFC5	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K96249452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36629
EFO-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.67717
ATP5H	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-CA-04-2009(H1N1)_48Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.54439
BRD-K12460934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12601
K029AX	CCLE Cell Line Gene Expression Profiles	1.0	1.68428
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Lung carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
CTCF_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K08589866_OSI-906_SW948_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.885833
BRD-K14144134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56827
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17559
Intrinsic component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.144
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26497
Integral component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.065
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60997
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.927521
CTCF_fibroblast of pedal digit skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951929
BRD-K67666705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87936
CTCF_fibroblast of pedal digit skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38984040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34494
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.15234
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23652
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.626918
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.861081
ERG	ChEA Transcription Factor Targets	1.0	null
BRD-K44204252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85783
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.16831
TUBA1A	Pathway Commons Protein-Protein Interactions	1.0	null
GCN1L1	Pathway Commons Protein-Protein Interactions	1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K11003742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50221
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_downregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFG8-0626-SM-3GILJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2127
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.898979
Mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844624
superficial stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1554
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30531
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HT-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34251
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14048
BRD-K29408413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21142
GSE149075_6_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96265882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06516
superior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.831189
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212638
cisplatin_homo sapiens_gpl570_gds3910	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K40826084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12585
WEE1_druginhibition_307_GSE38972	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.8705
TP53	Pathway Commons Protein-Protein Interactions	1.0	null
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9806
BRD-K25907192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15062
Interanterodorsal nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.0304
16715129-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
membrane-enclosed lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.058056
periventricular stratum of r3Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04234
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.7263
dorsal endopiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24232
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24126
pinealocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.755364
primary motor cortex (area M1, area 4)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0676
Sarcoma_SARC_TCGA-HB-A3L4-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43432
CTCF_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K04875192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01455
7442_RPL18A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539645
CEBPD	ENCODE Transcription Factor Targets	1.0	null
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.903642
Cognition	HuGE Navigator Gene-Phenotype Associations	1.0	null
Right_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.40533
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.47208
mitochondrial chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.259473
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-TSE9-0426-SM-3DB81	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856763
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.03555
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23136
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.1122
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.726606
SH-4	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.84565
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
WM115_SKIN	CCLE Cell Line Proteomics	1.0	2.24509
SYNGR1	Pathway Commons Protein-Protein Interactions	1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
STAT3-1855785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
triangular septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.89081
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
mammarygland.lact.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.979392
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894362
infection	GAD High Level Gene-Disease Associations	1.0	0.293278
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary auditory cortex (core)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.68301
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UJHI-0426-SM-3DB8Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50271
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17724
Respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.376
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55794
Diabetic cardiomyopathy	KEGG Pathways 2026	1.0	null
heart_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.59397
MGME1	Pathway Commons Protein-Protein Interactions	1.0	null
FOS_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLOD3	Pathway Commons Protein-Protein Interactions	1.0	null
Uterine cervix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.547
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3781
kidney	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Organic acidemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
SLC29A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24015
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4696
Lung adenocarcinoma_LUAD_TCGA-64-1676-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NPJ8-2126-SM-3MJGK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833788
spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K70791360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26039
BRD-K64800655_PHA-793887_MCF10A_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3433-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TUBB3	Pathway Commons Protein-Protein Interactions	1.0	null
Cybrid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952145
BRD-K24246830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19885
CTCF_GM12870_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12865_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K90163297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87952
BRD-K39489370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17934
Hyperplasia	CTD Gene-Disease Associations	1.0	1.44899
inferolateral temporal cortex (area TEv, area 20)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.86938
BRD-K45092891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08242
superficial stratum of r10Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89182
CTCF_keratinocyte_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.866979
CD-16-KY17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241886
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00137
mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
vorinostat_homo sapiens_gpl10558_gse35242	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.951114
GSE80446_0_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BC-52-WF67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259925
MAFF	ENCODE Transcription Factor Targets	1.0	null
Phosphopantothenoylcysteine decarboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.992
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.16108
BRD-K38424085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39271
r7 part of the nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.11543
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90363
BRD-K00081911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38917
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38235
TDG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58669
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900539
BRD-K94258680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29279
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.6928
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
oxidoreductase activity, acting on nad(p)h	GO Molecular Function Annotations 2015	1.0	null
CTCF_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Basolateral amygdalar nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.93204
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HADHA	Pathway Commons Protein-Protein Interactions	1.0	null
Piriform-amygdalar area, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24232
CLPX	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K39681206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17781
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04347
GTEX-XYKS-0226-SM-4BRW3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2012
mitochondrial respiratory chain complex I assembly	GO Biological Process Annotations 2023	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.694147
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
EEF1B2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
JIYOYE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1362
MAGED1	Pathway Commons Protein-Protein Interactions	1.0	null
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55881
Acute Myeloid Leukemia_LAML_TCGA-AB-2969-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UFL1	Pathway Commons Protein-Protein Interactions	1.0	null
Cardiac microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.552
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304098
electron transport chain	GO Biological Process Annotations 2015	1.0	null
PMC8101445-mbc-32-475-s003.xlsx-HEK_Tim22_KD-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SARS-BatSRBD_72Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.88771
RKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05395
PMC11960529-mmc4.xlsx-Atrial_ZNF711_KOoverCT-gene_ZNF711	Rummagene Transcription Factor Associations 2026	1.0	null
Leber congenital amaurosis_Retina_GSE3249	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.66387
ri1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.626
NCL	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K85716998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04365
Organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Kidney Chromophobe_KICH_TCGA-KL-8328-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NF-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALDH1B1	Pathway Commons Protein-Protein Interactions	1.0	null
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30836
19235837-TableS2a	GeneSigDB Published Gene Signatures	1.0	null
GSE95685_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.872609
GTEx Nerve 20-29 vs 40-49	GTEx Tissue-Specific Aging Signatures	-1.0	-5.1373
CSTB_KO_GDS5089_486_mouse_Cerebellum and granule neurons	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SLC25A19	Pathway Commons Protein-Protein Interactions	1.0	null
ACHN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27679
Brain Lower Grade Glioma_LGG_TCGA-RY-A83Y-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C19orf70	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K71391283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04066
SW620	BioGPS Cell Line Gene Expression Profiles	1.0	1.2209
GTEX-XV7Q-0826-SM-4BRV7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840694
RBBP4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE206270_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Basolateral amygdalar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17072
CRCGN016_MCF10A.TP53.M_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21206
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mammillary body	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23335
SFXN1	Pathway Commons Protein-Protein Interactions	1.0	null
Ubiquinone-1	HMDB Metabolites of Enzymes	1.0	null
RPN2	Pathway Commons Protein-Protein Interactions	1.0	null
3-methylglutaconic aciduria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
oxidoreductase complex	GO Cellular Component Annotations 2015	1.0	null
BRD-K30558628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85625
CRCGN008_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1155
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20195
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302745
BRD-K76833108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14536
subunits	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
8598_SUPT5H_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13053
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.28253
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20154
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3744
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.063
BRD-K11168234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00442
WC-16-IR43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231598
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATP5A1	Pathway Commons Protein-Protein Interactions	1.0	null
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.544
Bilateral frontal polymicrogyria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.374
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
superior parietal lobule, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.879935
KSR1_knockout_126_GSE28228	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.46638
8651_TAF10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535088
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929773
mitochondrial intermembrane space	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-U3ZH-1726-SM-3DB79	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928816
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.18477
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20857
BRD-K22485581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25469
Brain - Substantia nigra	GTEx Tissue Gene Expression Profiles 2023	1.0	2.9291
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2359
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00132
TE4	CCLE Cell Line Gene CNV Profiles	1.0	2.25665
mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.510418
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.16613
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41272
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.017
GANAB	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162688_1_v_4_pink1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral septal nucleus, intermedio-intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19847
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
FTC-133	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SU8686	CCLE Cell Line Gene Expression Profiles	-1.0	-1.65473
SOX4_KD_GDS2193_37_human_adenoid cystic carcinoma derived cells ACC3	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.825412
NDUFC2	Pathway Commons Protein-Protein Interactions	1.0	null
SLC25A11	Pathway Commons Protein-Protein Interactions	1.0	null
Congenital merosin-deficient muscular dystrophy 1A	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.339
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMC1	Pathway Commons Protein-Protein Interactions	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43379
skeletalmuscle	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.18366
abomasum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.288158
urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.92536
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953573
precentral gyrus, left, superior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.946674
BRD-K62504352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17858
1522_CERK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.05203
Respiratory chain complex I (gamma subunit) mitochondrial	CORUM Protein Complexes	1.0	null
Nephroblastoma_Renal Tissue_GSE2712	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.7446
benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053848
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE221327_6_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
postcentral gyrus, left, superior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.996878
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.939029
GTEX-WYJK-1026-SM-3NM8W	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26007
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1115
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-1.45956
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.03273
BRD-K45056520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43786
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.944454
PPP2CA	Pathway Commons Protein-Protein Interactions	1.0	null
Triangular nucleus of septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.90312
CRCGN017_MCF10A.TP53.M_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23135
organelle envelope lumen	GO Cellular Component Annotations 2015	1.0	null
NDUFB5	Pathway Commons Protein-Protein Interactions	1.0	null
DNAJB14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39289
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0096
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7832-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64375
FOXP2	ChEA Transcription Factor Targets	1.0	null
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2264
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ARHGEF2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A21524347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33983
2376_DROSHA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.686338
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Nodulus (X), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36353
STAT3	ChEA Transcription Factor Targets	1.0	null
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.62937
CEBPB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BAG2	Pathway Commons Protein-Protein Interactions	1.0	null
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	1.0	0.844843
H2BK12ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE81803,GSE81912_2_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
TMED10	Pathway Commons Protein-Protein Interactions	1.0	null
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.89483
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MEF2A_MEF2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K43025624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60408
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6K1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMD3	Pathway Commons Protein-Protein Interactions	1.0	null
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2537
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05697
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34204
SUM149PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.95705
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K23704908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07131
Exocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.518
COPG2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K82107433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04316
Ovary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.683554
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.59079
KYSE-510	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.1411
oxidative phosphorylation	GO Biological Process Annotations 2025	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.063
NADH dehydrogenase complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Subparafascicular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.42785
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2783-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XPT6-0126-SM-4B65S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6456
SLC16A1	Pathway Commons Protein-Protein Interactions	1.0	null
decreased total retina thickness	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-A86748098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20896
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.702572
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-8.14036
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.8739
BC-01-JL64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.951525
GTEX-S7SE-0005-SM-2XCEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20886
MAZ	ENCODE Transcription Factor Targets	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K32118188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63202
RIPPLY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5762
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7166-01A-12R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOT4-1126-SM-4B66E	GTEx Tissue Sample Gene Expression Profiles	1.0	2.45343
GTEX-X62O-0826-SM-46MW8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1366
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A852-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
heart muscle	HPA Tissue Gene Expression Profiles	1.0	2.24804
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.19868
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal retina blood vessel morphology	IMPC Knockout Mouse Phenotypes	1.0	null
NCI-H1648	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.916767
BRD-K94082609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03441
GSE138019_3_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:H23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84683
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HNRNPF	Pathway Commons Protein-Protein Interactions	1.0	null
heart muscle	HPA Tissue Protein Expression Profiles	1.0	0.910487
MYC_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NA-30-HS87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228929
GSE206502_2_v_1_igf2bp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975321
REST-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.865685
succinate-CoA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.72
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.54096
DDX52	Pathway Commons Protein-Protein Interactions	1.0	null
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19519
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1003
WDR24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3832
Paraventricular nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.50869
BICR16	CCLE Cell Line Gene CNV Profiles	1.0	1.40659
Huntington's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
H2AK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
organelle envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.233459
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.48959
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
BRD-K13873561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02899
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08749
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145639_7_v_4_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.93824
hsa-miR-4520a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
SP1	ENCODE Transcription Factor Targets	1.0	null
PANC1	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.948022
BRD-K85271599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0565
VMRCLCP	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53188
Septofimbrial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.38668
CFPAC1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39623
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
BRD-K63102090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13331
GTEX-WHPG-1026-SM-3NMBA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07192
PPP6C	Pathway Commons Protein-Protein Interactions	1.0	null
SLC25A10	Pathway Commons Protein-Protein Interactions	1.0	null
C2orf47	Pathway Commons Protein-Protein Interactions	1.0	null
increased bone mineral content	MGI Mouse Phenotype Associations 2023	1.0	null
GSE156708_1_v_0_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
Type 1 diabetes mellitus_Muscle - Striated (Skeletal) (MMHCC)_GSE1659	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.25858
KARPAS-45	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5634
CDC42EP1	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_17420_Mut_Jak3_SRP168570	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146072_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.73247
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMC3	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrial respiratory chain	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.731076
mitochondrial inner membrane	GO Cellular Component Annotations 2015	1.0	null
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.49172
GTEX-WYJK-1126-SM-3NM9Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93218
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.915495
18667080-TableS2	GeneSigDB Published Gene Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AV-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00147
r9 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26511
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32226
KDELR2	Pathway Commons Protein-Protein Interactions	1.0	null
ALVA31	BioGPS Cell Line Gene Expression Profiles	1.0	1.39359
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34616
QH2	HMDB Metabolites of Enzymes	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5051-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25161864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0011
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936934
BRD-K38273665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00452
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22532
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22794
Nausea	CTD Gene-Disease Associations	1.0	1.11843
Oxidoreductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.445
GSE150055_0_v_1_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.16271
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.901734
BRD-K24977393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06729
BRD-K69932463_AZD8055_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K50190949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06349
BRD-K48875630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38777
Mhs	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.635
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49472
LoVo	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.67136
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2771
SIN3A	ENCODE Transcription Factor Targets	1.0	null
cisplatin_homo sapiens_gds3910	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q2AH-0526-SM-2I3ED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46061
BRD-K94582731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53403
ZCCHC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05573
SOX2-20726797-SW620-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.45175
WM-266-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.878135
JUND	ENCODE Transcription Factor Targets	1.0	null
DorsalRootGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.04891
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
mitochondrial respiratory chain complex i	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11293
GTEX-N7MS-0926-SM-2HMIZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84779
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
Perturb_97_KO_cat3a_SRP091011	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.75018
Early myoclonic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
Mitochondrial intermembrane space	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K56441027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02926
RAB11A	Pathway Commons Protein-Protein Interactions	1.0	null
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMA7	Pathway Commons Protein-Protein Interactions	1.0	null
GSE231648_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LZTR1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6TW-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FFAR4_KO_GDS4811_507_mouse_adipose	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
C2BBE1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.19692
GTEX-REY6-0626-SM-2TF4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04654
SNU-283	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.48088
GTEX-WHSE-0926-SM-3NMBS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89249
seminal vesicle	HPA Tissue Protein Expression Profiles	1.0	0.910487
mcf7	HPA Cell Line Gene Expression Profiles	1.0	1.03754
Nephronophthisis 11	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.057
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL8	Pathway Commons Protein-Protein Interactions	1.0	null
PAX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2805
NCIH2030	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67148
HOXD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2758
COPA	Pathway Commons Protein-Protein Interactions	1.0	null
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067873
ERBB2_knockdown_237_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.83166
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38302
CRCGN015_MCF10A.WT.HP_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41596
hematopoietic system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
cellular respiration	GO Biological Process Annotations 2025	1.0	null
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58981
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Primary somatosensory area, upper limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1797
Disease Progression	HuGE Navigator Gene-Phenotype Associations	1.0	null
ZFX-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE200320_3_v_2_mfge8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SF767	CCLE Cell Line Gene Expression Profiles	1.0	2.32402
breast	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
NDUFA6	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R53T-0926-SM-3GADH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66516
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829263
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28129
Oxoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.801
subunit	GeneRIF Biological Term Annotations	1.0	null
BRD-K26217579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00709
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35385
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87455
GSE95688_7_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63065
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210101,GSE210114_5_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DDX3X	Pathway Commons Protein-Protein Interactions	1.0	null
SARS-CoV_12Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.34928
BRD-K98941192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42814
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840509
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.56105
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K01624114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24282
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.63538
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IFIH1	Pathway Commons Protein-Protein Interactions	1.0	null
DDX6	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2968
KYO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.79789
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.201
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902526
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
heart_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.73049
DARS	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.369185
RAB6A	Pathway Commons Protein-Protein Interactions	1.0	null
RANBP2	Pathway Commons Protein-Protein Interactions	1.0	null
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.929995
submammillothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48793
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.143
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.710158
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.4625
EE-98-PF86_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200735
SNU761	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55532
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM12872_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SDF4	Pathway Commons Protein-Protein Interactions	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Endometriosis_Endometrium_GSE6364	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.58554
Metallochaperone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.002
Adrenocortical carcinoma_ACC_TCGA-OR-A5JD-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE171486_4_v_0_ddx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.851068
SYK_knockdown_190_GSE54065	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.4116
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20857
NFYB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRDM14	ChEA Transcription Factor Targets	1.0	null
Electron transfer flavoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.984
GTEX-RNOR-0826-SM-2TF5C	GTEx Tissue Sample Gene Expression Profiles	1.0	2.044
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3648
r10 part of vagal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05046
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nadh dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.935488
hsa-miR-4303	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Perturb_6169_KD_PROX1_SRP073100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.70977
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.190185
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chromosome, telomeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.321201
estradiol_homo sapiens_gpl6102_gse11567	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HA1E	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.874
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.67215
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respiratory chain complex I	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Respiratory electron transport	Reactome Pathways 2024	1.0	null
BRD-K17140735_-666_SW948_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE246053_4_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
vena cava	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.640833
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08479
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4535
LNCaP cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.36636
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE246053_4_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
HSPH1	Pathway Commons Protein-Protein Interactions	1.0	null
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56142
KDM1A	ENCODE Transcription Factor Targets	1.0	null
GTEX-WH7G-0426-SM-3NMBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18266
liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.07428
FOXP2	ENCODE Transcription Factor Targets	1.0	null
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073519
periventricular stratum of r9Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55114
ERBB2_knockdown_238_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.75055
SISO	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.85837
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.15008
GBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6269
SW-620 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.0624
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN2_n_EN2	Rummagene Transcription Factor Associations 2026	1.0	null
prednisolone_homo sapiens_gpl570_gse32962	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
C32	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.03428
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMC4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-O5YV-0326-SM-2I5H2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4407
HP1BP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14581
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165548_2_v_1_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6488577-41598_2019_43010_MOESM2_ESM.xlsx-Proteingroups_MBD3_pos-Gene_names_MBD3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE162739_6_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Basolateral amygdalar nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02775
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03166
TMEM109	Pathway Commons Protein-Protein Interactions	1.0	null
Medial geniculate body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.169
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.826919
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05411364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25226
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.02908
RAB10	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WQUQ-1426-SM-3MJFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52526
KM-H2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.46724
u138mg	HPA Cell Line Gene Expression Profiles	-1.0	-1.39147
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5221
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56075657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08892
NKG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07405
HOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.95
mitochondrial respiratory chain	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04072
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-A5KJ-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Oxidative phosphorylation(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
GSE231648_0_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3176
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.137
CTCF_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
substantia nigra, compact part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0198
GTEX-XPT6-0226-SM-4B65L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34773
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4114-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.76298
SLC25A6	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12289921-41467_2025_62099_MOESM5_ESM.xlsx-MI-2-80-Gene_Symbol_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PB-09-OE00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212265
increased bone mineral content	IMPC Knockout Mouse Phenotypes	1.0	null
TE14	CCLE Cell Line Gene Expression Profiles	1.0	2.12845
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14323
CTCF_choroid plexus epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12005
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.833368
SIN3B	ChEA Transcription Factor Targets	1.0	null
TE-9	GDSC Cell Line Gene Expression Profiles	1.0	1.88141
COPG1	Pathway Commons Protein-Protein Interactions	1.0	null
RB1_KD_GSE50532_659_human_OSTEOBLASTS	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01156
ranolazine_mus musculus_gpl1261_gse25767	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04181
nucleus of diagonal band	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41317
BRD-K51898276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26966
mitochondrion	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.210894
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18458
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I1-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969036
large intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86429
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r3 part of parvicellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04698
RPL12	Pathway Commons Protein-Protein Interactions	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hippocampal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.536
CTCF_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GID8	Pathway Commons Protein-Protein Interactions	1.0	null
NDUFB3	Pathway Commons Protein-Protein Interactions	1.0	null
lung	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.914448
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTA2	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-99-HO76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292623
Integral component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.269
NUP205	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60877
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_foreskin fibroblast_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91917132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03914
mammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46143
mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058186
NCI H322M	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.972629
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.40026
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.081
MYOD1_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF3C1	Pathway Commons Protein-Protein Interactions	1.0	null
SNU308	CCLE Cell Line Gene Expression Profiles	1.0	1.95571
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13883
periventricular stratum of r7Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01371
Primary somatosensory area, trunk, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6068
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.80228
nadh dehydrogenase activity	GO Molecular Function Annotations 2015	1.0	null
Heart ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.144
NCAPG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00384703
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLK2_knockdown_87_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.1528
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MEX3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56967
CTCF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.932671
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24804
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.519108
E2F6	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Testis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.679613
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.86199
METFORMIN HYDROCHLORIDE	DGIdb Drug Targets 2026	1.0	0.326741
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09017
bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10839
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_13_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16586
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RPL23A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U8XE-0926-SM-3DB8V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34424
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831861
MDAMB453	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.078
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26078
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.934008
NDUFS3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	1.0	2.66283
EEF2	Pathway Commons Protein-Protein Interactions	1.0	null
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.73874
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
mitochondrial	GeneRIF Biological Term Annotations	1.0	null
mitochondrial electron transport, NADH to ubiquinone	GO Biological Process Annotations 2023	1.0	null
Perturb_12263_KD_DDX18_SRP385779	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-16.5119
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-98-A53J-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 839.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.893732
stomach	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076541
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.234302
BRD-K65873444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19212
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.46304
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.024092
SARS	Pathway Commons Protein-Protein Interactions	1.0	null
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09676
CTCF_GM12869_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845255
XRCC5	Pathway Commons Protein-Protein Interactions	1.0	null
Mammary-nk cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.179257
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2658
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21565
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_251_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVCAR8	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.4151
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97355
BRD-K45367466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06573
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6605
myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.082283
SNU601	CCLE Cell Line Gene CNV Profiles	-1.0	-3.10613
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.13033
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985737
BRD-K97348029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46458
trim28_23493425_cd71pluster119plus_sorted_from_bone_marrow_lof_mouse_gpl6887_gse44063	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.306378
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.934485
YT	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.82984
GTEX-X5EB-0526-SM-46MVP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975809
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
P30-OHK	GDSC Cell Line Gene Expression Profiles	-1.0	-2.27678
NRF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149075_6_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PTGER1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00521493
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NOMO1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.36339
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A3Y1-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
U-698-M	GDSC Cell Line Gene Expression Profiles	-1.0	-1.86021
BRD-K59069382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75171
GTEX-R55E-1026-SM-2TC5S	GTEx Tissue Sample Gene Expression Profiles	1.0	2.97651
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.567381
CTCF_GM12864_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPL36	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.93056
H4K20me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908984
PABPC1	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
aerobic electron transport chain	GO Biological Process Annotations 2025	1.0	null
mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K18290923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58138
MYO9A	Pathway Commons Protein-Protein Interactions	1.0	null
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.32865
NCI-H2803	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.71237
G361	CCLE Cell Line Gene Expression Profiles	1.0	1.65603
organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041807
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22922
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984745
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	1.0	1.431
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20966
medial (magnocellular) part of MD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.55854
NCIH854	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50065
ARF4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K45642123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32168
BRD-K21786986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14688
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WL46-0726-SM-3LK5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09411
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49029187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50412
LYPLAL1	Pathway Commons Protein-Protein Interactions	1.0	null
PI4KA	Pathway Commons Protein-Protein Interactions	1.0	null
BB-44-SX65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334412
6708_PPWD1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.603545
BRD-K47030799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2986
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
germ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.524771
PMC8651586-726_2021_3013_MOESM2_ESM.xlsx-Table_S1_TP53_URA-Genes_in_dataset_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
PRDM14-21183938-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05325
deferasirox_homo sapiens_gpl570_gds3558	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K88941096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9442
SKMEL1	CCLE Cell Line Gene Expression Profiles	1.0	2.0659
Sarcoma_SARC_TCGA-DX-A8BK-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC5A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00528236
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.16233
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of foreskin _hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC89	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13555
Infertility, Male	CTD Gene-Disease Associations	1.0	1.10838
Poisoning	CTD Gene-Disease Associations	1.0	1.05163
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32309
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.858
537 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19142
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.29027
CTCF_GM12869_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE203158_12_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TP53INP2_KO_GSE54917_384_mouse_Quadriceps muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13814
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18982
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.54837
Superior vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17327
BRD-K19946529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61919
esophagus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3387
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
interanterodorsal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.86856
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18555
GTEX-O5YT-0326-SM-32PKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19319
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16586
AURKB	Pathway Commons Protein-Protein Interactions	1.0	null
intermediate stratum of r7BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71141
GTEX-TSE9-0726-SM-3DB8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969767
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HIV-1_LAI_12Hour-UV_treatment_None_GSE56484	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	3.05393
LRP12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00753948
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4431
Anteromedial visual area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66005
RAD21_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.68974
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CBWD6	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IL17RB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31184
PMC11329632-41419_2024_6969_MOESM3_ESM.pdf-91-ZNF689_ZNF689	Rummagene Transcription Factor Associations 2026	1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE166914_1_v_0_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
colorectal cancer cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.933296
BRD-K33194123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01575
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.407181
SMARCA5	Pathway Commons Protein-Protein Interactions	1.0	null
duodenum	HPA Tissue Protein Expression Profiles	1.0	0.910487
BRD-K33274327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3219
GTEX-OOBJ-0326-SM-33HBO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0359
PANC0327	Achilles Cell Line Gene Essentiality Profiles	1.0	1.54376
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24259
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0463
Fumarate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.86
SIRT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00515739
HOXB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7056
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.49128
FAM162A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
L33	Achilles Cell Line Gene Essentiality Profiles	1.0	1.45324
GTEX-T5JW-0226-SM-4DM7I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857908
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Unnamed_1_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
HIPK2_knockout_171_GSE39253	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-0.724845
GTEX-QMR6-1926-SM-32PL9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906557
HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.795
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.215761
GSE226355,GSE226357_1_v_4_ybx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KNS81	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.34092
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TIMM23	Pathway Commons Protein-Protein Interactions	1.0	null
AKAP8L	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IPO9	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RPL27	Pathway Commons Protein-Protein Interactions	1.0	null
GSE201042_6_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7935918-41598_2021_84338_MOESM1_ESM.xlsx-ST12-Unnamed_0_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
SF-295 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.421
MAPK14_knockdown_101_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.25677
Brain asymmetrical skew (vertical)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.652288
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HO-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45198
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.555289
TRAPPC2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22789
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00076
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RFC2	Pathway Commons Protein-Protein Interactions	1.0	null
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.9192
Respiratory system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8796
6696_PPP4C_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.00313
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.16137
Proteinuria	CTD Gene-Disease Associations	1.0	1.08161
IC-80-CT90_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202672
Perturb_9525_Mut_Thra_SRP334033	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.07152
CCT8	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACHN	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.27287
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08795
Malaria	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.530103
FMR1_KD_GDS4759_333_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
COLO-829	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.16455
YWHAE	Pathway Commons Protein-Protein Interactions	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47T-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NEUROD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69168
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6267
Interanteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46354
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.324
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23K-01A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
7562_RRP15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.566668
15988031-TableS5	GeneSigDB Published Gene Signatures	1.0	null
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1059
CDK2_knockdown_90_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.04269
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OE19	GDSC Cell Line Gene Expression Profiles	1.0	1.51969
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15453
mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H3118	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.52057
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20375
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
LN340	CCLE Cell Line Gene Expression Profiles	1.0	1.56744
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A5RJ-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastric	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.899482
nr2c2_20864514_liver_1yo_lof_mouse_gpl4134_gse21903	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.0722
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table4_gnomAD_EAS_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7U8-06A-21R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977692
Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pioglitazone_mus musculus_gpl2897_gse8806	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPL3	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04681
BRD-K62213484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41428
BRD-K19378563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82749
prolonged RR interval	MGI Mouse Phenotype Associations 2023	1.0	null
Respiratory chain complex IV	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.939
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Primary somatosensory area, lower limb, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.7886
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
RHOD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77096
16651409-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
496100416_FWM_dementia_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.55043
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.3115
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889013
5860_NUDCD3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.560955
COX6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0684
LAGE3	Pathway Commons Protein-Protein Interactions	1.0	null
pedunculo(pontine) tegmental  nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18836
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2507
Fatty acid beta-oxidation multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.732
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5808
CRCGN017_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.02428
DHRS7B	Pathway Commons Protein-Protein Interactions	1.0	null
PTRH2	Pathway Commons Protein-Protein Interactions	1.0	null
Outer mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.15
WNT5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62555
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.39808
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07242
oxidative phosphorylation	GO Biological Process Annotations 2023	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61978712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15906
cellular_component	GO Cellular Component Annotations 2015	1.0	null
YY1-21170310-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.955738
RFX7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6349
MYOG	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A76B-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11258719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58717
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.39489
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.243
Acetaminophen	CTD Gene-Chemical Interactions	1.0	null
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.30415
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.89571
Anemia	CTD Gene-Disease Associations	1.0	1.08868
TRIM28	ENCODE Transcription Factor Targets	1.0	null
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840366
prostate gland	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-0.894677
mitochondrial membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Vagina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.032
CTCF_GM12865_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.834869
pioglitazone_rattus norvegicus_gpl341_gse21329	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.65386
PLK1	Pathway Commons Protein-Protein Interactions	1.0	null
PC-14 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.774
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PSMA5	Pathway Commons Protein-Protein Interactions	1.0	null
DHX15	Pathway Commons Protein-Protein Interactions	1.0	null
MAD2L1	Pathway Commons Protein-Protein Interactions	1.0	null
superficial stratum of PHyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.52982
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.05117
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLR26	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50305
GTEX-U8XE-1126-SM-3DB8W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55948
GLUD1	Pathway Commons Protein-Protein Interactions	1.0	null
primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.85797
AXIN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00452995
SMC3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14576
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56428
ZBTB8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35181
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.15661
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8288
Obesity-related traits	GWAS Catalog SNP-Phenotype Associations	1.0	0.070053
HL60	Achilles Cell Line Gene Essentiality Profiles	1.0	1.18486
AD-58-PW17_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298322
PMC8586238-41467_2021_26788_MOESM6_ESM.xlsx-S2A_CDE_genes-S2A_CDE_-_genes_of_the_two_CCD_genes_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PRPF6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE150072,GSE169209_6_v_11_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.79282
BRD-K61206648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50986
Vastus lateralis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.206
SUM-52PE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.949
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291644
PRECLH	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70807
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain stem	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05061
HCC461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01082
Nonalcoholic fatty liver disease	WikiPathways Pathways 2024	1.0	null
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03578
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0567
pallidal septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27112
BICR18	CCLE Cell Line Gene CNV Profiles	1.0	3.17124
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853023
CLINDAMYCIN-PO4	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67099
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.492
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.984059
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.31897
cellular process	GO Biological Process Annotations 2015	1.0	null
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058383
BRD-K97934318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64371
excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.657698
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54576
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XPVG-0726-SM-4B658	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43181
colon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5091
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.959137
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
brain ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16714
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.465
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
POLE	Pathway Commons Protein-Protein Interactions	1.0	null
GSE193588_1_v_2_pax3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.665576
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.298516
HYOU1	Pathway Commons Protein-Protein Interactions	1.0	null
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0869
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.64414
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00728
Perturb_3923_KD_VPS37B_SRP266781	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.29743
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.238406
PSMC6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.93553
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.191
ESYT2	Pathway Commons Protein-Protein Interactions	1.0	null
r9 portion of vagal motor nucleus (postmigratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79544
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12009
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Adenoma, Liver Cell	CTD Gene-Disease Associations	1.0	1.21599
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5925
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973376
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SV2A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RNH1	Pathway Commons Protein-Protein Interactions	1.0	null
SLC25A4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K27578003	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63623
mitochondrial membrane	GO Cellular Component Annotations 2025	1.0	null
BRD-K02708799_GSK-1059615_PC3_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5881-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QEL4-0926-SM-3GAD1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80426
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.4313
Acute Myeloid Leukemia_LAML_TCGA-AB-2886-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K12683022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56318
Respiratory electron transport	Reactome Pathways 2014	1.0	null
hippocampus (hippocampal formation)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.846529
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13146
BRD-K81206010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02472
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25652
GSE190384,GSE190386_2_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
Atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.981
3395_GLIS1_ENST00000312233.2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.50288
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.447
generation of precursor metabolites and energy	GO Biological Process Annotations 2015	1.0	null
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91128
MAST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00772
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JA-23-QE71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204202
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03026
BRD-K22069962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24666
RPL13	Pathway Commons Protein-Protein Interactions	1.0	null
small intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
cumulus-oocyte complex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.762
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
spinal trigeminal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06173
GTEX-P44H-1126-SM-48TBU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05657
GSE203072_2_v_3_rpl3l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21106
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
periventricular stratum of r9Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.79373
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE252857_1_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.944375
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72181
r9 part of the vestibular column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02622
GSE57875_1_v_0_hnrnpl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3727
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PAX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9386
BRD-K91225366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.5285
YWHAB	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P4PQ-0326-SM-2HMJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88943
BRD-K81537454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44277
BRD-K38446773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1755
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40845
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997094
basolateral amygdaloid nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11269
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.8361
JEKO1	CCLE Cell Line Gene CNV Profiles	1.0	1.72183
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995548
GTEX-R55G-0526-SM-2TC5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32783
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A5UA-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87412446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86407
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054168
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.01367
HDAC2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K61021741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96006
Primary motor area, Layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19266
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nucleus of the solitary tract, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03425
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00186
BRD-K53665750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31774
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.588
bed nucleus of stria terminalis, lateral amygdaloid division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31043
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
proton-transporting two-sector ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.502
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Transmembrane transporter complex	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Parafascicular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17941
SNU-601	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.21441
LU-139	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.84108
BRD-K90294313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32407
Mitochondrial crista junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.699
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262869
Skin	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.22028
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.7302
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.145
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20897375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82572
Sulfide	HMDB Metabolites of Enzymes	1.0	null
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.474231
retromammillary area, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.11143
BRD-A79316179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99769
inner SZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.94235
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K41334119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.16189
GSE190384,GSE190386_3_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYO9B	Pathway Commons Protein-Protein Interactions	1.0	null
SLC37A4	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2925-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FANCD2	Pathway Commons Protein-Protein Interactions	1.0	null
RHBDD2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K36460068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17989
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72176
PSMD2	Pathway Commons Protein-Protein Interactions	1.0	null
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.031
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6245
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.38523
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDLIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14445
BRD-K24984327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05111
Intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.34271
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38868
DNAJB11	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN010_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1421
organelle inner membrane	GO Cellular Component Annotations 2015	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0814
HADHB	Pathway Commons Protein-Protein Interactions	1.0	null
HIGD1A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
OVTOKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.95621
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RPS27	Pathway Commons Protein-Protein Interactions	1.0	null
BC-45-VY95_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250219
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K04219533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77237
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854901
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.869888
SLIT2	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH2126_LUNG	CCLE Cell Line Proteomics	1.0	2.37341
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CANX	Pathway Commons Protein-Protein Interactions	1.0	null
SARS-CoV_96Hour_23935999_GSE47961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.10835
GSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.996
18362358-Table10	GeneSigDB Published Gene Signatures	1.0	null
GTEX-P44H-0526-SM-2XCF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90188
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47232
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16586
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EIF4ENIF1	Pathway Commons Protein-Protein Interactions	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.70886
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864227
HCC38	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.89297
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-0426-SM-2I5F5	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08015
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
NDUFA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25231
PARP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K65005459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49287
spi1_17041602_preleukemic_hscs_lof_mouse_gpl1261_gds2411	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.034994
BRD-A58803929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97058
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206270_2_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE241036_4_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DA-27-BW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22627
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6167
organelle inner membrane	GO Cellular Component Annotations 2023	1.0	null
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K58017833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01981
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216646
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57556
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
periventricular stratum of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.20175
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.51153
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPLP1	Pathway Commons Protein-Protein Interactions	1.0	null
respiratory chain complex I	GO Cellular Component Annotations 2023	1.0	null
GTEX-SUCS-0326-SM-32PLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51747
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
GSE168797_4_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE197571_3_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_fibroblast of skin of abdomen_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_8517_OE_CamkdeltaC_SRP287242	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.52985
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.97224
NDUFS5	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung non-small cell carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.401
GSE57871_8_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.48109
BICR22_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	2.06077
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.834234
KAT2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.58705
EP300	ENCODE Transcription Factor Targets	1.0	null
LU-135	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.00708
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K72774661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23409
CTCF_GM12867_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hindbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
lateral mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56234
RXF393	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.68409
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02834
CHTF18	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A43076080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38495
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9250250-12987_2022_351_MOESM2_ESM.xlsx-Table_S2-Table_S2_Spearman_s_rank_correlation_with_COL6A2_to_extract_CAA-specific_and_vascular-specific_pathological_changes_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
VDAC1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K88087295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04062
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.519768
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14227
PHB2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Connective tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.032
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12598
mitochondrial nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.259473
19192944-TableS4	GeneSigDB Published Gene Signatures	1.0	null
ATXN2L	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K91973560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07119
BRD-K65410345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74153
proton motive force-driven mitochondrial ATP synthesis	GO Biological Process Annotations 2025	1.0	null
GSE95688_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58670847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20011
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28072
BRD-K30382953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57258
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
TARS2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K51003626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09332
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A26343863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00045
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3691-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
mitochondrial membrane	GO Cellular Component Annotations 2015	1.0	null
HIST1H2BL	Pathway Commons Protein-Protein Interactions	1.0	null
GSE77108_4_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.915495
SPTLC1	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.967326
ndufb7	GeneRIF Biological Term Annotations	1.0	null
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LS513	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.30886
RNF31	Pathway Commons Protein-Protein Interactions	1.0	null
PTGES2	Pathway Commons Protein-Protein Interactions	1.0	null
Ventral pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07223
SKP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82795
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7083
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5886-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Succinate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.855
FBLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11223
MDA-MB-468	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06192
PRPF8	Pathway Commons Protein-Protein Interactions	1.0	null
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.929441
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.75846
mitochondrial part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01512588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29635
BRD-K87532481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88319
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17X-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vermiform appendix	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CCT3	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2857-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K44856541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87601
GTF3C5	Pathway Commons Protein-Protein Interactions	1.0	null
Organellar large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.699
OVKATE	CCLE Cell Line Gene CNV Profiles	1.0	2.4408
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GIGYF1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978412
Adrenocortical carcinoma_ACC_TCGA-OR-A5JJ-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12929
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NELFE	ENCODE Transcription Factor Targets	1.0	null
HSPA4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE121866_0_v_3_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BTG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20603
H3K9me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07885
HNRNPA0	Pathway Commons Protein-Protein Interactions	1.0	null
orbital frontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37739
CTCF_fibroblast of the aortic adventitia_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE94814_2_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.40505
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K25280080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29173
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.135
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	Reactome Pathways 2014	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC-827 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.504
Lung adenocarcinoma_LUAD_TCGA-49-4486-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.389082
IDH3A	Pathway Commons Protein-Protein Interactions	1.0	null
DNAJA1	Pathway Commons Protein-Protein Interactions	1.0	null
HEY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.881107
BRD-K28465224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29227
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASPH	Pathway Commons Protein-Protein Interactions	1.0	null
Nucleus of the solitary tract, gelatinous part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15035
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95854766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40225
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
SARS-BatSRBD_12Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.6657
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Vascular Diseases	CTD Gene-Disease Associations	1.0	1.11466
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PBXIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57135
HuO9	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.2581
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K44193634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22883
PMC7003708__F1	PFOCR Pathway Figure Associations 2024	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18242
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K24369860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42741
POU3F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37177
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ALDH18A1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26545
RAB7A	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10800016-table_s5_20230913_ddad186.xlsx-FvsC_-_DUX4_II-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.08231
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.63785
SPOPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10521
ID-26-HX79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225746
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estradiol_rattus norvegicus_gpl85_gds2311	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC25A33	Pathway Commons Protein-Protein Interactions	1.0	null
NRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG	ChEA Transcription Factor Targets	1.0	null
GSE211128_3_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
septal nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01787
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288359
KDM1A	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7098486-mmc2.xlsx-Kgg_Quant_NGN2_AAVS_-_WCL-Unnamed_2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LI-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.779
Substantia nigra cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREBBP	ENCODE Transcription Factor Targets	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29584
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.061595
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68G-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158320,GSE183351_0_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
MEOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1704
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K33197627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44533
DAOY	CCLE Cell Line Gene CNV Profiles	1.0	1.41066
H3K4me1_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE169697,GSE169725_0_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32712
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CTCF_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AQ-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-4944-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lateral dorsal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.599
GSE133683_1_v_5_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Organelle inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.149
23132-87	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A4 noradrenergic cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28959
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.879452
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47016
BRD-K79202867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51626
TMEM205	Pathway Commons Protein-Protein Interactions	1.0	null
layer 1 of AOV cortex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.69136
TemporalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.942136
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.032
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06711
HSD17B12	Pathway Commons Protein-Protein Interactions	1.0	null
SARS-dORF6_72Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.87366
DDB1	Pathway Commons Protein-Protein Interactions	1.0	null
SEC61B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.643535
CTCF_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NDUFB8	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular organelle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.070499
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.946563
H3K9ac_Rectal Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
CCT4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043378
CEBPB_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.690672
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03296
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02708799_GSK-1059615_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TUBA1C	Pathway Commons Protein-Protein Interactions	1.0	null
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47016
Sarcoma_SARC_TCGA-DX-A3M2-01A-21R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GF1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K00530465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39146
CCDC85C	Pathway Commons Protein-Protein Interactions	1.0	null
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	2.55614
reuniens nucleus, main part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32588
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
catalytic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.046043
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8038
FBL	Pathway Commons Protein-Protein Interactions	1.0	null
Respiratory chain complex I (holoenzyme), mitochondrial	CORUM Protein Complexes	1.0	null
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.69145
SF3B3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHWD-0426-SM-3LK83	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57578
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HOXC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9692
PMC12234789-41467_2025_61560_MOESM3_ESM.xlsx-Supplementary_data_1-Only_YY1_IP-MS_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K24387453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26222
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056263
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.878689
NCIH1915	CCLE Cell Line Gene CNV Profiles	-1.0	-2.24875
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902642
increased grip strength	MGI Mouse Phenotype Associations 2023	1.0	null
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43432
RPSA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K36170990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0419
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42752
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041196
HT-3	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.44924
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.95002
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Charcot-Marie-Tooth disease X-linked recessive 4	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.427
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIK3R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35154
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965658
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
SQSTM1	Pathway Commons Protein-Protein Interactions	1.0	null
centromedian nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.29114
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypertrophy	CTD Gene-Disease Associations	1.0	1.47348
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20441
BC-00-YH62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274154
aerobic respiration	GO Biological Process Annotations 2025	1.0	null
BNC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02253
nadh dehydrogenase (ubiquinone) activity	GO Molecular Function Annotations 2015	1.0	null
DYNC1H1	Pathway Commons Protein-Protein Interactions	1.0	null
TAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80857
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876356
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06211
KDM5B	ENCODE Transcription Factor Targets	1.0	null
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Integral component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.268
cerebellum	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K64660038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40761
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23296
BRD-U82589721_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85I-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Breast Cancer_Mammary gland_GSE2528	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.25646
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
LRPPRC	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952634
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30756
MLLT11	Pathway Commons Protein-Protein Interactions	1.0	null
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324162
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139540_0_v_2_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K77697725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54355
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01082
BRD-K12347309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00895
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.639026
KPNA4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04676
GSE202603_1_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE262134_0_v_1_dnajc12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95685_2_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EIF4A1	Pathway Commons Protein-Protein Interactions	1.0	null
DNAJA3	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
L3.6pl cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
BRD-K82638914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34412
CTCF_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.713438
mitochondrial ATP synthesis coupled electron transport	GO Biological Process Annotations 2025	1.0	null
gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041286
ZNF143	ENCODE Transcription Factor Targets	1.0	null
PMC12587232-DOM-27-6894-s001.pdf-18-PPARG_PPARG	Rummagene Transcription Factor Associations 2026	1.0	null
PGC-1alpha_Deficiency_GDS4904_310_mouse_Aged gastrocnemius muscle - 10 weeks	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE126463_1_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42004
GTEX-Q2AG-1026-SM-33HBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06462
DDOST	Pathway Commons Protein-Protein Interactions	1.0	null
GSE96777,GSE96778_1_v_0_zbtb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NDUFS8	Pathway Commons Protein-Protein Interactions	1.0	null
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.509233
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
znf148_21828133_erythroblast_lof_human_gpl571_gse31092	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.523507
GTEX-UPK5-0226-SM-3GAEV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54877
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058102
SNU1076	CCLE Cell Line Gene CNV Profiles	1.0	1.92579
Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3579
Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833194
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.858267
BRD-K94858557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03501
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5083-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SE5C-0626-SM-2XCDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58817
CTCF_brain microvascular endothelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE101527_0_v_1_smad4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Oxidative phosphorylation(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
EPHX1	Pathway Commons Protein-Protein Interactions	1.0	null
skin fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.736794
C2BBe1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.38123
IRAK4_knockout_41_GSE12124	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.89659
LMNA	Pathway Commons Protein-Protein Interactions	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.43514
r8 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3255
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
aerobic electron transport chain	GO Biological Process Annotations 2023	1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.32728
BRD-K77801455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.04788
BRD-K93380196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40602
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.32
5216_MRPL34_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.530079
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SARS-dORF6_24Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.904094
NOP56	Pathway Commons Protein-Protein Interactions	1.0	null
lymph	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-A02927672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01938
Mitochondrial inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
STOML2	Pathway Commons Protein-Protein Interactions	1.0	null
inner SZ in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.901904
MAFK	ENCODE Transcription Factor Targets	1.0	null
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DNAJA4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE110178_2_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13407
TECR	Pathway Commons Protein-Protein Interactions	1.0	null
periventricular stratum of r8Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32409
GSE155305_3_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.50328
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271029
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TU-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
PMC10702478-jci-133-161348-s262.xlsx-High_targets8listes_TPM_DE-List_of_high_confidence_targets_of_PPAR_genes_regulated_after_18h_in_Mo_by_PA_PPARA	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SDHB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00596365
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
intermediate stratum of r7BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32127
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08357
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF121	Pathway Commons Protein-Protein Interactions	1.0	null
OC-314	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.33443
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
3871_HNRNPL_P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.551639
CTCF_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE173201_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
EBF1-22473956-LYMPHODE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39385
organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.299452
KIAA0368	Pathway Commons Protein-Protein Interactions	1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TTC1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE193993_4_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF302	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25413
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prion disease	KEGG Pathways 2026	1.0	null
NDUFA4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K77609086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08021
GSE196671_6_v_8_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
brownfat	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.63383
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_WI38_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymphoid tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
RPS28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17592
posteroventral (inferior) parietal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.846348
parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
chr9_122144177_C_T_b38	GTEx eQTL 2025	1.0	1.09521
GSE207914_2_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SYNJ2BP	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:F24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19735
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE216147_0_v_3_rbm20_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TM9SF2	Pathway Commons Protein-Protein Interactions	1.0	null
PPARD	ChEA Transcription Factor Targets	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6813-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterolateral cortical amygdaloid area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31283
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.668024
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11465086-mmc2.xlsx-Table_ES_1_markers_c0_LPS_Vs_Co-Gene_Expression_Data_1_markers_c0_LPS_Vs_Control_related_to_Figure_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47254434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56281
proposed	GeneRIF Biological Term Annotations	1.0	null
BRD-K80803211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58644
Mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.175
Perturb_1408_KO_Pth1r_SRP341470	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Mitochondrial electron transport chain function	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.28611
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
OVKATE	CCLE Cell Line Gene Expression Profiles	1.0	1.59185
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ST13	Pathway Commons Protein-Protein Interactions	1.0	null
NDRG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22547
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
oxidoreductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.092119
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.1942
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17326
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K76515685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51056
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7237
ZNF281	Pathway Commons Protein-Protein Interactions	1.0	null
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29V-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mitochondrial isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.032
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.8146
RAD21_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H3122	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.0819
GSE214823,GSE214824_0_v_2_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27248268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40851
Huntington disease	KEGG Pathways 2026	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
WA-01 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.936
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34692
gallbladder_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.866115
23132/87	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-N7MS-1626-SM-3LK5F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852357
GTEX-QEG5-0926-SM-2TC64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15969
Right_Atrium	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.05034
DPM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52172
medial part of r7B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.64537
Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPP2R1A	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9911
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2324
REST-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.935278
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
SIK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01334
BRD-K55311609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05907
PMC6345883-41598_2018_37397_MOESM10_ESM.xlsx-AR_D0_VS_D7_W_B29__TRANS-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1009
CRCGN013_HEPG2_24H:J06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36007
decitabine_homo sapiens_gpl571_gse29077	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A5VM-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211286_4_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.59161
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Chromophobe renal cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.756
NCIH1581	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5662
YY1	ENCODE Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25X-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PEER	CCLE Cell Line Gene CNV Profiles	-1.0	-1.98507
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NLGN1_KD_GDS4759_335_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
786-0	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.17691
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A624-01A-22R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
pc3	HPA Cell Line Gene Expression Profiles	1.0	2.21188
Lung squamous cell carcinoma_LUSC_TCGA-39-5036-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.521523
HCC3153	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.16413
Sinus node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
lateral amygdaloid nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36117
SP in entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23315
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16242
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE246053_1_v_2_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55765
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71517
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
isthmic vestibulocerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22541
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33307
GTF3C3	Pathway Commons Protein-Protein Interactions	1.0	null
Breast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.063
Exosome (RNase complex)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.604
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.22974
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4344782__F11	PFOCR Pathway Figure Associations 2023	1.0	null
CHERP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.98168
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46386
cx9ccontaining	GeneRIF Biological Term Annotations	1.0	null
r9 (gustatory) part of solitary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55277
EIF3H	Pathway Commons Protein-Protein Interactions	1.0	null
NDUFB9	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.42585
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23909
mantle zone of RMa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64205
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0869
ZFX	ChEA Transcription Factor Targets	1.0	null
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48616
CTCF_HEK293_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358963
Gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
BRD-K73539077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19036
posterior paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.58261
AUP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE151494_1_v_9_nrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Infantile neuronal ceroid lipofuscinosis_Brain_GSE6678	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.09475
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055713
MTHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.137
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506736
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29467
Paragigantocellular reticular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24391
BRD-K24815102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01181
trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-IS-A3K7-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K85456600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00645
GSE246053_1_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.753779
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U7-06A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
retromammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.64389
GTEX-X585-0011-R5A-SM-46MVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04672
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18904
HOXB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.421
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
PTPLAD1	Pathway Commons Protein-Protein Interactions	1.0	null
1298_CCDC84_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.504764
GTEX-XUJ4-0626-SM-4BOOO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50848
BT-474	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
BRD-K95048194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2143
PMC7657662__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.1706
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL21	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K52383401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46971
BRD-K76984291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54154
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN012_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12015
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
small intestine	HPA Tissue Protein Expression Profiles	1.0	0.910487
EPRS	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33507
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.650898
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.5719
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.633911
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.060055
PPT1	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial fatty acid beta-oxidation multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.735
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5470-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
protein complex	GO Cellular Component Annotations 2015	1.0	null
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13376
CRCGN017_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44792
PMC10679653-mmc4.xlsx-ISL1_KO_Markers_T_L-Unnamed_0_ISL1	Rummagene Transcription Factor Associations 2026	1.0	null
NDUFV2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.37436
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.329
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.943772
RPS7	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_11073_Mut_Tak1/Ripk1_SRP256942	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.7359
SLC1A5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24769
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.846755
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.93517
TUBB6	Pathway Commons Protein-Protein Interactions	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.4081
Metabolism	Reactome Pathways 2014	1.0	null
PORCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02534
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.97064
PRDM14-21183938-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-V1D1-0726-SM-4JBH7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875751
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.63977
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29649
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29584
GSE242083,GSE242098_2_v_1_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Flp-In-T-REx cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.897
Mitochondrial electron transfer flavoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.289
Perturb_1351_OE_TRAF4_SRP292631	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.53921
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315688
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
JURLMK1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.13147
ETS1	ENCODE Transcription Factor Targets	1.0	null
Retrograde endocannabinoid signaling	KEGG Pathways 2026	1.0	null
BRD-K73808079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27017
SP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.896314
FAD	HMDB Metabolites of Enzymes	1.0	null
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0226-SM-3GIKN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29042
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872584
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.990039
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BMI1	ChEA Transcription Factor Targets	1.0	null
BRD-K50479239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68501
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.61782
GE-22-ME44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211948
TAF1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K41423946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38107
BD-04-NG34_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305135
acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053942
Lung squamous cell carcinoma_LUSC_TCGA-58-8391-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1186
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1215
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35814
SCO2	Pathway Commons Protein-Protein Interactions	1.0	null
septohypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.59446
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10697
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22687
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.68723
organelle envelope lumen	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-WHWD-0326-SM-3LK6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18867
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Renal proximal tubule epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.628
oxidation-reduction process	GO Biological Process Annotations 2015	1.0	null
ventral posterior lateral nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.987289
BRD-K24396733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46572
P32-ISH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RAB21	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857884
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.31416
GSE118077_1_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
dipyrocetyl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38672
Lung squamous cell carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
r7 part of nucleus prepositus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42987
PMC7003708__F1	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K92544320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00627
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19729
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5541_NDUFA8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.14104
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYBBP1A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44234
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233746
neurological	GAD High Level Gene-Disease Associations	1.0	0.293278
NDUFA13	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_GM12801_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K51061297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.596
MYC	Hub Proteins Protein-Protein Interactions	1.0	null
decreased total retina thickness	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K86263698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01535
PMC12021535-CPH4-15-e70011-s001.xlsx-S21-KLF2_KLF2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
motif	GeneRIF Biological Term Annotations	1.0	null
PMC7934853-jciinsight-6-141851-s210.xlsx-Beta3-Unnamed_0_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X4EP-0326-SM-3P5Z6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27583
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
GSE114992,GSE114993_8_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.423879
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.92366
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPMI7951_SKIN	CCLE Cell Line Proteomics	1.0	9.54076
CPC-N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2759-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5037
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0821
PELO	Pathway Commons Protein-Protein Interactions	1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01783
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EVX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7991
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67826
BRD-K63807676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22008
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1359
Lung adenocarcinoma_LUAD_TCGA-50-5068-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO678	CCLE Cell Line Gene Expression Profiles	-1.0	-2.30515
yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.184582
BRD-A75409952_wortmannin_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BSDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39615
CTCF_MCF-7_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A03898562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38677
FAM186B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
HS578T	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.64779
Peripheral_Blood_Mononuclear_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.29297
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.242363
Icotinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.570018
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.119683
GSE217071_1_v_2_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CCT2	Pathway Commons Protein-Protein Interactions	1.0	null
SSR3	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCM7	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34205
GSE107505_3_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07252
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.17693
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40468
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A562-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_fibroblast of gingiva_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998644
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_8-ILL1_T_Cells_FOXP3_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
r9 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.53272
PSMB5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	1.0	1.02643
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFYB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrial membrane part	GO Cellular Component Annotations 2015	1.0	null
Hypertension	CTD Gene-Disease Associations	1.0	1.33523
GTEX-REY6-0526-SM-2TF5M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906813
PMC6522222-NIHMS977514-supplement-Sup_Table_15.xlsx-WT3_WT5-Unnamed_0_POU6F2	Rummagene Transcription Factor Associations 2026	1.0	null
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NEC8	GDSC Cell Line Gene Expression Profiles	1.0	2.07403
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15801
BRD-K03035008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62658
Gitter cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.611
Hypertrophy, Left Ventricular_Myocardial tissue_GSE2459	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.78828
UQCRC2	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.299
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.10282
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.049013
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
DE-85-FR73_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248888
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5491-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN011_HEPG2_24H:G08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08795
Adrenocortical carcinoma_ACC_TCGA-OR-A5K8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CYB5B	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-4745-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K89952634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28944
Mesothelioma_MESO_TCGA-MQ-A6BN-01A-12R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Submedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44505
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.32993
Mediodorsal nucleus of the thalamus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.695
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.09882
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.512271
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.885833
somatic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.338545
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K71368065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01069
Mitosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.721
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
Fe2+	HMDB Metabolites of Enzymes	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K22487336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59868
GTEX-U3ZH-0326-SM-3DB7A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75781
BRD-K43714461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14741
BRD-K04378630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12292
Mitochondrial degradosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.675
Pheochromocytoma and Paraganglioma_PCPG_TCGA-XG-A823-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPL26	Pathway Commons Protein-Protein Interactions	1.0	null
PGRMC2	Pathway Commons Protein-Protein Interactions	1.0	null
lateral hypothalamic area, anterior part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.935477
MTA1	Pathway Commons Protein-Protein Interactions	1.0	null
ARL1	Pathway Commons Protein-Protein Interactions	1.0	null
Mast syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.467
SALE	CCLE Cell Line Gene Expression Profiles	-1.0	-2.12193
BRD-K32199799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.86915
CRCGN015_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11265
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTA3	ENCODE Transcription Factor Targets	1.0	null
NLGN3_KD_GDS4759_336_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
PCYOX1	Pathway Commons Protein-Protein Interactions	1.0	null
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.223
HUWE1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-REY6-0326-SM-2TF5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856909
MECP2_KD_GDS4759_334_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TMPO	Pathway Commons Protein-Protein Interactions	1.0	null
PML	ENCODE Transcription Factor Targets	1.0	null
muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.079154
gall bladder	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06242
GSE216238,GSE216241_0_v_1_tonsl_human	RummaGEO Gene Perturbation Signatures	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.27595
heart_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.57204
cerebellar cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07621
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE205316,GSE205317_2_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NUP133	Pathway Commons Protein-Protein Interactions	1.0	null
Artery - Aorta	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.835657
BRD-K16670438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37969
GSE110178_4_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.34885
ChIP_ZFX_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909357
GTEX-S7PM-0426-SM-3NM91	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835508
HDAC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00331822
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K21759602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65156
FOXA1_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6643872__F2	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K81952048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01373
organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07098
PMC9904760-elife-79363-supp2.xlsx-MDS1-Gene_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mitochondrial metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.2656
CC-68-YZ44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270956
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.43912
BRD-K42855618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11539
Kidney - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	3.75779
BMI1-19503595-MEFC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
medial part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42987
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325726
BRD-K05939258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43292
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.485564
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.457
NDUFV1	Pathway Commons Protein-Protein Interactions	1.0	null
r7 portion of the hypoglossal motor nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12162
r10 part of external cuneate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89182
SMC2	Pathway Commons Protein-Protein Interactions	1.0	null
RAD21_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9601604-NIHMS1841143-supplement-SuppTable-2.xlsx-FOXO3-specific_targets-FOXO3-specific_targets_1218_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
SK-N-FI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.38089
U20S	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.14447
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.898292
CRCGN016_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5679
adrenal adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.75005
Left_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.53361
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214823,GSE214824_5_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MRPS34	Pathway Commons Protein-Protein Interactions	1.0	null
Mitochondrial membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1155
lower basal lateral hypothalamic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10294
H4K20me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.71183
CAKI1_KIDNEY	CCLE Cell Line Proteomics	1.0	3.17464
Fetal Death	CTD Gene-Disease Associations	1.0	1.05163
CDC7_knockdown_109_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.55089
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979641
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.96424
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.552345
GTEX-U4B1-0726-SM-4DXUA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879176
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.129
OAW42	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.12195
BRD-K95871937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05534
macromolecular complex binding	GO Molecular Function Annotations 2015	1.0	null
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EIF2S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27526
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.11323
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03387
Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
periventricular part of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00141
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205901
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46633
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.55378
Rectum adenocarcinoma_READ_TCGA-DY-A1DE-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56341841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06558
colorectum	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.243605
GSE186620_0_v_1_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KB-58-XI48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202173
SEC22B	Pathway Commons Protein-Protein Interactions	1.0	null
6-phosphofructokinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.739
Mitochondrial respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.386
CFL1	Pathway Commons Protein-Protein Interactions	1.0	null
r11 part of the trigeminal column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09486
DKMG	CCLE Cell Line Gene CNV Profiles	1.0	1.65712
6642_PPM1G_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.796985
BRD-K37213205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2622
TNPO3	Pathway Commons Protein-Protein Interactions	1.0	null
layer V of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10093
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
RBBP7	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158456_2_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
levetiracetam_rattus norvegicus_gpl1355_brainstem_gds1864	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.277036
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.12658
TIGAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558819
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.24628
FBXW7	Pathway Commons Protein-Protein Interactions	1.0	null
EIF3E	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.64813
ATP6V0A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62266
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936708
external segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26546
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Aerobic respiration and respiratory electron transport	Reactome Pathways 2024	1.0	null
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6338
GTEX-WL46-0926-SM-3LK7T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79244
BRD-K23997756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5373
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.33687
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2IR-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ME1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.48851
BRD-K54370483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6714
r11 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09607
NDUFAF3	Pathway Commons Protein-Protein Interactions	1.0	null
excretory gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitochondrial intermembrane space	GO Cellular Component Annotations 2025	1.0	null
PFDN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95289
NCI-H322M	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.82539
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39613
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.783253
BRD-K92358687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06727
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.553841
CRCGN017_MCF10A.TP53.M_24H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18956
RUNX1_01_47	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60476
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.35783
SSR4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE239578_0_v_4_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PSME4	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61I-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.51897
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02608
GSE87404,GSE87812_1_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60368
membrane	GO Cellular Component Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5044-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC22A31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64805
GSE139239_2_v_6_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC25A22	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_12264_KD_DDX18_SRP385779	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MMS19	Pathway Commons Protein-Protein Interactions	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K51937785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05555
GSE114258_1_v_0_foxk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
4593_LIN52_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.597798
BRD-K01754917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03373
SLC25A21	Pathway Commons Protein-Protein Interactions	1.0	null
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	0.885741
NDUFA10	Pathway Commons Protein-Protein Interactions	1.0	null
GSE115542_2_v_3_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	1.0	1.02229
heart_5a	HPA Tissue Sample Gene Expression Profiles	1.0	3.06661
GSE252857_1_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MEF2D_KD_GDS4759_339_mouse_E16 primary cortical neuron cultures	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
KLHDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13088
Secondary motor area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.94207
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.569
rostral interstitial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08857
PMC12405659-CTM2-15-e70437-s001.xlsx-Supplementary_Table_5-BioGrid-interaction_protein_with_MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
periventricular stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.26244
anteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09399
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.76735
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NADH	HMDB Metabolites of Enzymes	1.0	null
IQGAP2	Pathway Commons Protein-Protein Interactions	1.0	null
Lactic acidosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.223
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.01603
BRD-K14121002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15192
BRD-K91410469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29791
PMC10661700-41525_2023_383_MOESM2_ESM.xlsx-Supp_Table6_gnomAD_EUR_GCR-SYMBOL_NR3C1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15053
CRCGN017_MCF10A.WT.HP_24H:F18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06225
CAL27	CCLE Cell Line Gene CNV Profiles	1.0	1.3368
DHCR7	Pathway Commons Protein-Protein Interactions	1.0	null
RSV_48Hour_22398282_GSE32138	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.86745
nucleoid	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.252564
BRD-K86986621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03481
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12445
Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.39737
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72403
NGFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00550874
GSE87299_2_v_3_nr1d1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166401
AM-38	GDSC Cell Line Gene Expression Profiles	1.0	1.61624
GTEX-RWSA-0926-SM-47JXW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855519
CCDC47	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYH9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30811
BRD-K21672174_Ro 28-1675 ?_A375_24.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LAMA84	CCLE Cell Line Gene Expression Profiles	-1.0	-1.89494
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01747
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02805
NCIH2030	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52164
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.11132
GTEX-P44H-0726-SM-48TBT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2692
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
layer 2 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07557
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.29549
valproic acid_mus musculus_gpl1261_gds3002	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5A	ENCODE Transcription Factor Targets	1.0	null
Mitochondrial small ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.462
skeletal muscle	HPA Tissue Gene Expression Profiles	1.0	1.18187
GTEX-POYW-1326-SM-48TCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915273
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.24258
CRCGN016_MCF10A.WT.HP_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21598
BRD-K87191742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28103
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291198
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.32748
Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.868812
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAGLN2	Pathway Commons Protein-Protein Interactions	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926145
HAX1	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0531
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845255
3639_HAUS6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.641905
BRD-K81217407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24042
PAM complex, Tim23 associated import motor	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.686
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41629
SN4741 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.757
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09706
Mitochondrial pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.601
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCT7	Pathway Commons Protein-Protein Interactions	1.0	null
urinary bladder	HPA Tissue Protein Expression Profiles	1.0	0.910487
Alzheimer Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.63545
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.542651
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.40774
parafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10346
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.59222
GSE211126_1_v_4_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RAF1	Pathway Commons Protein-Protein Interactions	1.0	null
stomach	HPA Tissue Protein Expression Profiles	1.0	0.910487
r7 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3765
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.966256
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TUBB	Pathway Commons Protein-Protein Interactions	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.941233
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246532
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34857
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.36802
NDUFA11	Pathway Commons Protein-Protein Interactions	1.0	null
CNBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33481
pharmacogenomic	GAD High Level Gene-Disease Associations	1.0	0.293278
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977079
AFG3L2	Pathway Commons Protein-Protein Interactions	1.0	null
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
increased heart rate variability	IMPC Knockout Mouse Phenotypes	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-MB-A5Y9-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K59523233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14769
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.73114
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.467
SP in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08599
FOXP2-21765815-NEURO2A-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Uterus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.396
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01082
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
XRCC6	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.65267
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.78568
H4K20me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.09822
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1419	CCLE Cell Line Gene CNV Profiles	1.0	1.5412
GTEX-WQUQ-1326-SM-3MJFF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18452
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08505
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.93222
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05146
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963046
BRD-K59191599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12593
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.50768
temporal muscle trigeminal motor cell group	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09486
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944417
NDUFB7	Pathway Commons Protein-Protein Interactions	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.915495
SQRDL	Pathway Commons Protein-Protein Interactions	1.0	null
intramolecular	GeneRIF Biological Term Annotations	1.0	null
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22824
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_SK-N-SH_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2046
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386476
ERG-20517297-VCAP-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K16167206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23148
BRD-K81619018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03234
mantle zone of r8BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10933
H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09603
leigh disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.49964
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053952
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263557
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
ILVBL	Pathway Commons Protein-Protein Interactions	1.0	null
Bed nuclei of the stria terminalis, posterior division, strial extension	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06002
BRD-K32839286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19192
CRCGN016_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49512
Oxidative phosphorylation	KEGG Pathways 2026	1.0	null
7507_RPS18_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.716128
rhombomere 11	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41958
TUBB2B	Pathway Commons Protein-Protein Interactions	1.0	null
RPL7	Pathway Commons Protein-Protein Interactions	1.0	null
Right atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.981
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904073
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SIRT6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18160665-TableS5	GeneSigDB Published Gene Signatures	1.0	null
PRPSAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29884
GSE203158_1_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
laminin-2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.626
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
mitochondrial respiratory chain complex I	GO Cellular Component Annotations 2023	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.423116
PMC10181932-41588_2023_1366_MOESM4_ESM.xlsx-Supplementary_Table_2-Supplementary_Table_2_Additional_information_for_all_SOX9-dependent_genes_SOX9	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.445137
IGR1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5109
CTCFL_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_HCT116_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56292
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16448
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15548
periventricular stratum of r10Lim	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05046
r10 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25308
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferior vena cava	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.776909
USF2	ENCODE Transcription Factor Targets	1.0	null
VAT1	Pathway Commons Protein-Protein Interactions	1.0	null
NOTO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45472
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE114992,GSE114993_9_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VAMP3	Pathway Commons Protein-Protein Interactions	1.0	null
PHGDH	Pathway Commons Protein-Protein Interactions	1.0	null
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3099
Inner mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.703
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE127790_10_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.05206
BRD-K29542628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.45439
SOX17_01_360	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59573
Parkinson disease	KEGG Pathways 2026	1.0	null
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6079
NADH dehydrogenase (ubiquinone) activity	GO Molecular Function Annotations 2023	1.0	null
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
membrane-enclosed lumen	GO Cellular Component Annotations 2015	1.0	null
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.950582
PMC6605752-JEM_20181726_TableS1.xlsx-MYC_translational_targets-Table_S1_Lists_of_translational_targets_of_MYC_in_MYC_ON_vs_MYC_OFF_P493_cells_and_their_5_UTR_sequences_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79833963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11526
GSE234289_3_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2749
C3	Pathway Commons Protein-Protein Interactions	1.0	null
mitochondrion	GO Cellular Component Annotations 2015	1.0	null
JD-44-KF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233176
BRD-K58220038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30482
Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.840495
periventricular stratum of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2746
PMC8208823-mmc2.xlsx-CDX2-KO_mesenchymal_DEG-feature_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
Mitochondrial large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.705
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.219
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20358
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07091
SLC25A12	Pathway Commons Protein-Protein Interactions	1.0	null
BD-61-OO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254358
internal segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.84881
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213145
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93041
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.34962
VPS28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52777
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.748593
BRD-K65496998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13093
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.51248
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
twin	GeneRIF Biological Term Annotations	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Organelle envelope lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.505
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831137
dorsolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25777
HNRNPM	Pathway Commons Protein-Protein Interactions	1.0	null
AGK	Pathway Commons Protein-Protein Interactions	1.0	null
Respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.127
OAW28	CCLE Cell Line Gene CNV Profiles	1.0	1.92502
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00743
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.25121
NDUFAF4	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.70975
CREBBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7684-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ANKRD55	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588724
primary motor cortex (area M1, area 4)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.905105
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.60836
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214186
mantle zone of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09607
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.258745
Lung Injury_Lung Tissue_GSE1541	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-3.00946
HUG1N_STOMACH	CCLE Cell Line Proteomics	1.0	2.33107
SLC18A3_KD_GDS4325_618_mouse_Heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16152
GSE138945,GSE138947_0_v_1_mboat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V955-0326-SM-4JBGV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877769
COPB1	Pathway Commons Protein-Protein Interactions	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cystic Fibrosis_Intestinal Epithelium_GSE765	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.1005
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14534
BRD-K14520048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68304
BRD-K72997741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34812
MSH6	Pathway Commons Protein-Protein Interactions	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
BRD-K73275682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42224
Dorsal motor nucleus of the vagus nerve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84798
PNKD	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_fibroblast of upper leg skin_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866058
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068815
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273565
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.032
PSMA4	Pathway Commons Protein-Protein Interactions	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2938-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08608
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066048
Integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE155305_2_v_1_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
496100396_HIP_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.36908
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE183994_3_v_0_scml2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28296
NCSTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08746
NONO	Pathway Commons Protein-Protein Interactions	1.0	null
ADRM1	Pathway Commons Protein-Protein Interactions	1.0	null
CSTB_KO_GSE47516_677_mouse_mouse cerebellum P7	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
chlorambucil_homo sapiens_gpl570_gds2970	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QLQ7-0526-SM-2I5G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36041
mantle zone of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46354
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.238
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
skin_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.857592
HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0489
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08397
GTEX-PWOO-0526-SM-2S1Q3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06101
hsa-miR-4282	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-K92440102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76972
2974_FARSB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.549492
CTCF_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.032
SRSF2	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K56943789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01019
ATF3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
BRD-K66494817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10106
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.72757
stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6436-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.85931
Kidney	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TNPO2	Pathway Commons Protein-Protein Interactions	1.0	null
MET_knockout_253_GSE30651	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.60964
NCI-H446	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.44013
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246661
HL-7702 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.588
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.5439
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517045
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.5923
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.78217
nutrition disease	GWASdb SNP-Disease Associations	1.0	0.417062
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-2.0331
BE-16-UV45_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.411155
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
ZBTB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0829
RUVBL1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.472
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.333
GSE148200_1_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GPBAR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00518987
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223908,GSE223909_4_v_8_serpinb3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Paraflocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13967
HDAC1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCFL	ENCODE Transcription Factor Targets	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37627
protein binding	GO Molecular Function Annotations 2015	1.0	null
Duchenne muscular dystrophy (DMD)_Muscle - Striated (Skeletal) - Diaphragm (MMHCC)_GSE1026	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.40557
C1QBP	Pathway Commons Protein-Protein Interactions	1.0	null
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
icSARS CoV_48Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.17068
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.63329
TIM22 mitochondrial import inner membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.288
Ebolavirus(ZEBOV)_6day_PBMCs_rNAPc2treated_21987740_GSE24943	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.180691
Gracilis muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.566
PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_II-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
Mitochondrial complex I deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.928
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIFLUPERIDOL-2HCL	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40841
CREM	ChEA Transcription Factor Targets	1.0	null
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.928815
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24565
r9 portion of ambiguous motor nucleus (postmigratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.17455
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2418
testosterone_mus musculus_gpl1261_gse17553	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXK2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE200352_5_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146074_10_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.68848
HCC2218	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01718
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NUP93	Pathway Commons Protein-Protein Interactions	1.0	null
GSK3B_knockdown_204_GDS4305	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.47797
NCIH1793	CCLE Cell Line Gene Expression Profiles	1.0	1.57035
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0159
oxidative phosphorylation	KEGG Pathways	1.0	null
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13275
ATP5L	Pathway Commons Protein-Protein Interactions	1.0	null
IMPDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68775
CFPAC1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78708
CHP1	Pathway Commons Protein-Protein Interactions	1.0	null
IPO7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K03476091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67773
disulfide	GeneRIF Biological Term Annotations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARCN1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE196540,GSE196542_4_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
B4GALT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51999
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL24	Pathway Commons Protein-Protein Interactions	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.36349
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ATP5O	Pathway Commons Protein-Protein Interactions	1.0	null
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPD	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A89983325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15823
hsa-miR-2053	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19519
superficial stratum of r11Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09486
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949312
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.974895
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UJMC-0526-SM-3GAE3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40619
GTEX-PLZ5-0626-SM-2I5F8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09053
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CPC-N	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.884737
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_Streptozotocin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149518
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y7-01A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WWYW-0011-R5A-SM-3NB3E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970456
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.36114
MXI1	ENCODE Transcription Factor Targets	1.0	null
RPS4X	Pathway Commons Protein-Protein Interactions	1.0	null
HSPD1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K43982279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03605
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3656
GTEX-XBEC-1226-SM-4AT65	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02727
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.841958
GTEX-R55G-2326-SM-2TC61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37977
DAD1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC10119310-41598_2023_33059_MOESM4_ESM.xlsx-KEGG-geneset-IRF5_IRF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-Genes_with_VDR_elements_only_control_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.228
GTEX-U4B1-0326-SM-3DB8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13693
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13804
DNAAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21545
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.03009
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.23137
eGFP-NR4A1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dexamethasone_mus musculus_gpl6105_gse44208	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
4-PPBP	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16546
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.8721
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12388
PMC12511553-41598_2025_19314_MOESM1_ESM.pdf-6-STAT2_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-2.88955
PCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.69803
SMC4	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.56407
CRCGN016_MCF10A.TP53.M_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.79931
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58371
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.526
GNB3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K10241968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14474
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57789
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3YO-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0844
SP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18178
BRD-K86914375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60408
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17167
BRD-K08009212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29465
NCIH1573	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35395
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.936471
Perturb_17380_KD_Stat6_SRP190223	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.25577
PMC5195898-NIHMS825571-supplement-6.xlsx-Sheet1-267_CIC_response_genes_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
mantle zone of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42987
TestisIntersitial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.987892
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.627404
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02096
PMC6526899__F3	PFOCR Pathway Figure Associations 2023	1.0	null
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205624
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
BRD-K99485242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17287
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.879003
YWHAQ	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE150072,GSE169209_6_v_9_qser1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
lateral subhabenular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04361
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13875
RT4	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.25221
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XY-1726-SM-46MVO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911397
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ACOT8	Pathway Commons Protein-Protein Interactions	1.0	null
Cytoplasmic exosome (RNase complex)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.611
RAB34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36834
CTCF_GM12873_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TYK-NU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.931216
LB373-MEL-D	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.67309
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K91191855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32122
Perturb_9618_KD_LKB1_SRP045048	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.55122
POLDIP2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6757
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.48713
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LL-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
colon_8a	HPA Tissue Sample Gene Expression Profiles	1.0	1.17145
PMC12260418-pnas.2425984122.sd02.xlsx-TEAD1_6fraction_test_result-Unnamed_3_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842675
Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE5786	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.29148
5541_NDUFA8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.19259
A-CA-04-2009(H1N1)_7Hour_None_GSE37571	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.79525
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.19956
16455954-TableS1	GeneSigDB Published Gene Signatures	1.0	null
GSE210655_1_v_6_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
duodenum	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Corn ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.669
posterior (caudal) superior temporal cortex (area 22c)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.892526
FAM229A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63719
TE-8	GDSC Cell Line Gene Expression Profiles	1.0	2.31845
GSE139239_1_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78866450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15633
PCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE123372,GSE123373_10_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04471
CTCF_fibroblast of villous mesenchyme_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TOM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.955
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939597
BRD-K23296676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05716
Microsporidian	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.644
GSE252857_2_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UBE2S	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A19829191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43405
XPO1	Pathway Commons Protein-Protein Interactions	1.0	null
DDX1	Pathway Commons Protein-Protein Interactions	1.0	null
CDK1	Pathway Commons Protein-Protein Interactions	1.0	null
Ampulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.736
BRD-K56426074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09205
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NF-21-HQ00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.340955
GTEX-N7MT-0011-R7a-SM-2I3FZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966194
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
perimammillary part of PHyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08907
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null