association	dataset	threshold value	standardized value
BRD-K28820796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.00273
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
t64-ovaries_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.75203
BRD-K30533903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05039
CRCGN011_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16675
BRD-K13927197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34903
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32555
BRD-K53508363	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17261
BRD-K50931403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09683
GSE148066,GSE157787_11_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2239
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.148
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K47885451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00054
BRD-K71877850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15412
GSE249544,GSE249637_6_v_2_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3648
BRD-K35193502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06685
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1117
PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DA-58-LZ09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211325
BRD-A54389315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15271
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0952
GSE215849_2_v_1_muc1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CDS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64375
4-P-PDOT	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99885
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12248
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.311907
BRD-A81615860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80135
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.49844
BRD-A47963183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29518
EE-32-EY37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244449
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.0159
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K52106083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00209
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37629
GSE158834_1_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GJD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01664
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.9284
CAKI1_KIDNEY	CCLE Cell Line Proteomics	1.0	3.91279
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.1261
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.347832
NTF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14759
BRD-K67141726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46396
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.565738
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7841
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.296
CA-48-SW47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218085
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8179
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K72821236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06229
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DB-01-BR68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232417
SR 3335	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.99
SNU1041	DepMap CRISPR Gene Dependency	1.0	2.46161
MEOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6106
BRD-K05710256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73171
BRD-K79179851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23323
GSE79572_0_v_1_pax8_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-U28903152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2558
BRD-K97951470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26655
UK 356618	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
BRD-K12460566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2084
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.362713
(S)-Zopiclone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.23
SKGIIIA	DepMap CRISPR Gene Dependency	1.0	2.09187
GSE241036_4_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FAM156B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75233
BRD-K19089958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07154
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.189
LRRC42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00563
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.907932
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K12801140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04606
levallorphan-tartrate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11591
BRD-K43282617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88129
hypotonia, ataxia, and delayed development syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.855
HOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8638
DE-73-JX23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346004
butyrylcholine-cl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40076
PMC10335698-pone.0285806.s007.xlsx-DMKN-shRNA_KD_Vs_ShSrc-Unnamed_3_AR	Rummagene Transcription Factor Associations 2026	1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.80789
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246718
BRD-K36618106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23883
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211788
BRD-K00191683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22678
CRCGN017_MCF10A.WT.HP_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2628
BRD-K47094330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03903
HOXD8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.116
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H4C6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18999
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.2594
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62746
BRD-A78042852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16706
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2037
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6995
BRD-K67007076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04448
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.561306
CRCGN016_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22487
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13364
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K07794261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50608
LSM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18706
oltipraz	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02212
GSE133516_5_v_6_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PGP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28502
GSE235066_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2932
FOXI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61428
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5144
GSE192689_0_v_3_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEx Muscle 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-13.4372
NCIH1755	DepMap CRISPR Gene Dependency	1.0	3.2348
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
strychnine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11527
NCIH2170_LUNG	CCLE Cell Line Proteomics	1.0	4.59341
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VCAN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11341
BRD-K94480039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08728
BRD-K13534347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62524
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7556
CRCGN017_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0523
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.142
ATP5F1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03247
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195663_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.325024
Macitentan	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.22
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1178
BRD-K83315952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03088
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HMGCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80521
MRPL32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03446
COPRS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0436
BRD-K53046137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01246
BRD-K12017137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13076
BRD-K52473019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00229
GSE150215_1_v_2_etl4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.408107
BRD-K86453556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7025
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2845
GSE175787_8_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
LI7	DepMap CRISPR Gene Dependency	1.0	2.85248
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NP3	DepMap CRISPR Gene Dependency	1.0	3.36303
GSE203158_5_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IC-05-AW29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264793
PMC10274973-media-3.xlsx-ST18-Unnamed_9_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
CPT1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00391417
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-Suppl_Table_6_DEG-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.532653
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K17303020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12003
GSE127916_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
PAX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5664
BRD-K84593579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25953
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32522318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1936
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.31029
BRD-K83603369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39748
BRD-K31806725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0206
HC-18-NB46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256079
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1319
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.5292
CRCGN015_MCF10A_48H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.49773
PMC12254391-41598_2025_8960_MOESM5_ESM.xlsx-fig-Supplemental_Table_6_Differentially_Expressed_Genes_DEG_between_siRNA_DLX4_and_siRNA_control_n_3_RA_FLS_cell_lines_per_treatment_group_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
Talazoparib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.48
BRD-K97763545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08321
141_ADAT3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.551812
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5012
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IA-27-CK10_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310794
PMC4224449-pone.0112193.s009.xlsx-PPI_MODULES_CLEAN_MAP_merg_OUT-Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
Frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.167
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.82606
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.548341
LHX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3533
SNU1079	DepMap CRISPR Gene Dependency	1.0	2.40938
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160304,GSE163392_7_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5651844-41467_2017_1173_MOESM10_ESM.xlsx-ZZZ3_occupied_genes-Supplementary_Data_7_ZZZ3_occupied_genes_and_overlaps_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K55442031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43411
GSE231524,GSE231526_0_v_1_dusp6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MERO95	DepMap CRISPR Gene Dependency	1.0	2.52746
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8461
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5721
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.08218
RCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44917
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322442
GSE189683_3_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NDUFB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34586
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6542
BRD-K77634326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91081
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.781747
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.489587
PMC6584338-jcav10p2520s2.xlsx-total_validated_1577_genes-STAT5A_STAT5A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K52237706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17725
small kidney	MGI Mouse Phenotype Associations 2023	1.0	null
LD-37-JE11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.266328
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92378241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73362
BRD-K14041149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22393
EN2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8668
GTEx BloodVessel 20-29 vs 50-59	GTEx Tissue-Specific Aging Signatures	-1.0	-14.3221
1778_COPS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.568715
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.041
BRD-K64626569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36326
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.645
CRCGN014_HEPG2_3H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27072
BRD-K58576935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1634
BRD-K53612850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29155
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237502
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K17940097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10527
BRD-A55063801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.425
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214931_4_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.5714
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0423
GSE231891_1_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
abnormal kidney morphology	IMPC Knockout Mouse Phenotypes	1.0	null
GSE158834_1_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K42797038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71461
BRD-K58827489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46093
GSE193282_2_v_0_cd44_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.547179
LC1SQ	DepMap CRISPR Gene Dependency	1.0	2.22737
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12260418-pnas.2425984122.sd01.xlsx-TEAD4_6fraction_test_result-Unnamed_3_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
U87MG	DepMap CRISPR Gene Dependency	1.0	2.51388
BRD-K89300187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23241
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXA7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8622
GSE207302,GSE207303_0_v_2_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MMGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06608
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.11933
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.117
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bestatin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
BRD-K83786559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15072
BRD-K63401195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50435
BARX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5226
PROKR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20234
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99944747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29003
CRCGN008_HEPG2_24H:F15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02
GSE151612_4_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9901
WAC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75511
GSE216273,GSE216292_14_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K91973560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02835
Darifenacin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
Cyanuric chloride	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
BRD-K62395041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25396
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5364
FCAMR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00453212
BRD-A98203122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83602
CRCGN016_MCF10A.WT.HP_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34287
CDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07875
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
aclarubicin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02051
BRD-K65137277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83205
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.95368
CRCGN015_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34608
BRD-K97576000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15812
CD47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9585
PMC10025425-mmc3.xlsx-ADNP_WH-gene_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31748787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21611
K562_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147045
GSE211286_4_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3371
acronycine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07422
BRD-K03727241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76171
BRD-K42081955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30499
HOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4328
ESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9697
CCDC86	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22626
BRD-K82883803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86806
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98513899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25344
BRD-K34524418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11782
PLK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21854
R-848	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
BRD-A70931301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83728
BRD-K25203350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5248
RPS17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587233
GSE159728,GSE159730_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201842
PLA2G4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23469
OE21	DepMap CRISPR Gene Dependency	1.0	2.03898
BRD-K98891210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14262
BTBD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06751
GSE210101,GSE210114_8_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97425
BRD-K66187822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69618
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1433
BRD-K08881846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79351
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K47906308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21377
CRCGN015_MCF10A.WT.HP_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06917
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXC8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.73
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9577
GSE151090_2_v_1_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ractopamine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92042
BRD-K90149465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58269
GSE180185_4_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AMG 487	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
GTEx Muscle 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-21.3512
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-A07870296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74127
BRD-K25196723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03871
FOSL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7527
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K04562748	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04731
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303422
Pramipexole	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301376
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7756
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268267
BT12	DepMap CRISPR Gene Dependency	1.0	2.52778
BRD-K23029982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22395
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06141
NFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40372
BRD-K49415484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3409
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6217
SOX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36335
GSE242290_1_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-86-YY62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.310186
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.663361
GSE205163,GSE205164_1_v_8_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNHIT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03534
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.696
POLR2H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09808
4EGI-1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
GSE142210_2_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K69659917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45524
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03346
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K27824953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34546
CRCGN015_MCF10A_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12969
OTX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6674
GSE101527_0_v_1_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
increased freezing behavior	MGI Mouse Phenotype Associations 2023	1.0	null
CACNB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00513085
BRD-K12524155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73862
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.3384
TBCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59519
ID-00-IC14_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243143
GATD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51061
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222298
BRD-K67572910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35776
BRD-K89278382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9767
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
AB-12-IS33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.370921
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1028
BRD-K09721123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13388
BRD-K36439830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3351
BRD-A54490075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15676
CRCGN009_HEPG2_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.12465
HY-50713	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
GSE206784_3_v_4_ninl_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9822
OVISE	DepMap CRISPR Gene Dependency	1.0	2.9842
CRCGN017_MCF10A.WT.HP_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45075
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_ZSCAN4-Unnamed_2_ZSCAN4	Rummagene Transcription Factor Associations 2026	1.0	null
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.4377
GSE139120_1_v_0_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4161
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.194
BICR22	DepMap CRISPR Gene Dependency	1.0	2.31157
pravadoline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20877
BRD-K62229896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43605
4149_INTS4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.90996
BRD-K90111788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48846
LPS853	DepMap CRISPR Gene Dependency	1.0	2.67606
A2058_SKIN	CCLE Cell Line Proteomics	1.0	2.26109
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SDCBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80242
NDT 9513727	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.83
BRD-K44244207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29452
BRD-K83832060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17563
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE48812_8_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
4-Benzylpyridine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.27
BRD-K19310540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71859
Laropiprant	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
GSE151364,GSE151366_1_v_2_taf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193993_5_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K50474387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02911
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6582
GSE193258,GSE193259_2_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.710629
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61676471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0399
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NHERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06519
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MFM223	DepMap CRISPR Gene Dependency	1.0	2.36914
GSE146687_2_v_0_eribulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3736
embryonic lethality prior to organogenesis	IMPC Knockout Mouse Phenotypes	1.0	null
Endocrine organ benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.316
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_11_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RNF149	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05217
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.5367
GSE206516,GSE206518_5_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2871
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134375_0_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
7827_SET_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.522879
Elf5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.1414
BRD-K93283197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55037
OF-05-CB18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242303
GATA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2582
6795_PRPF38B_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24732
Ro-3306	DeepCoverMOA Drug Mechanisms of Action	1.0	0.62
decreased prepulse inhibition	IMPC Knockout Mouse Phenotypes	1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.29822
ACTL6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03895
BRD-K40804250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00698
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6172843-13059_2018_1523_MOESM6_ESM.xls-Sheet1-Table_S5_mRNAs_variation_abundance_1_5-fold_in_YBX1-knockdown_BGC-823_cells_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.WT.HP_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3689
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.517778
GSE101748_0_v_1_apela_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6614
IGR39_SKIN	CCLE Cell Line Proteomics	1.0	3.62769
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3805
BRD-K20906316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40551
pantothenic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14615
GSE188721_3_v_4_mesp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
LNZTA3WT4	DepMap CRISPR Gene Dependency	1.0	2.16522
BRD-K96377358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04337
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K29039402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21967
4220_ITFG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.680112
CRCGN015_MCF10A.WT.HP_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03401
Persistent generalized lymphadenopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.366
11152_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.702635
BRD-K55104181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25386
GSE112761,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185922_1_v_2_riok2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.524392
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.864641
BRD-K38788176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48648
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.3386
CRCGN017_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9777
GSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7212
BRD-K32434600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33718
BRD-K78500251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00122
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.80229
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.472615
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3468
PMC11073998-41375_2024_2235_MOESM9_ESM.xlsx-THP1_phosphoproteome-Unnamed_2_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_unique_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K96076719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.40168
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.567126
BRD-K86288396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01423
BRD-K90361987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23849
BRD-K36835942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56913
CRCGN014_HEPG2_24H:D03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.89348
BRD-K83183132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14345
BRD-K12111274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37973
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE241036_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Roflumilast	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-62-RZ55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278581
NKX6-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2733
7501_RPS13_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.529746
Nucleoli	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
RAP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25981
GSE130437_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_ZSCAN4-Unnamed_3_ZSCAN4	Rummagene Transcription Factor Associations 2026	1.0	null
POC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42658
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K66327237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.24772
GSE134191_3_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A41208012	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70343
CCK81_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	14.1726
BRD-K93666423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03538
GSE201309_5_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CD-26-MB82_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258839
OA-12-SU22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216526
769P	DepMap CRISPR Gene Dependency	1.0	2.28776
KD-31-TU05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265841
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6715
SKMEL3_SKIN	CCLE Cell Line Proteomics	1.0	2.8238
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3607
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7364
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227466
BB-86-BE39_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341326
OSBPL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38845
BRD-K70302892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37628
BRD-K51750373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51004
Spinal cord	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.067
BRD-K09248459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05819
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6841
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3012
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K18197334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75253
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3544
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9928
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Teratocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53343
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K76197651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13999
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39099034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31621
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.312808
BRD-K98935620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01311
BRD-A14331394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08334
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7645
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29035
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_R_species_not_found_in_common_genes_of_LF_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1018
Type I spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
SPCS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18222
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BA-84-WN26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.503455
BRD-K88395026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71178
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE175787_13_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HS852T	DepMap CRISPR Gene Dependency	1.0	2.59432
PMC3590650-bjc2012518x7.xls-Sheet1-Supplementary_Table_S3_list_of_predicted_target_genes_for_miR29c_present_in_both_PITA_and_Targetscan_predictions_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235682_1_v_0_rbl2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PCNP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04345
CRCGN017_MCF10A.WT.HP_24H:O17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59395
GSE255680_1_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE168797_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11263707-41419_2024_6896_MOESM4_ESM.pdf-14-TCF7L2_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20026212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55131
BRD-K34639069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01816
FB-75-YG01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308512
GSE189653,GSE203344_5_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K95323025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42077
4939_MED17_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18526
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4858
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02671
GSE208435_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K93811242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85376
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213346
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9
BRD-K15273135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35533
NR1I2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2302
BRD-A38066207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64423
LHX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0534
SKNAS	DepMap CRISPR Gene Dependency	1.0	3.21903
BRD-K23232542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37945
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.945
Anamorelin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-3.28
BRD-K75164441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71037
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.485133
BRD-K69093885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41301
BRD-K23840704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57468
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286827
BRD-K05704547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13418
BE-38-UW72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247735
CRCGN015_HEPG2_48H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04883
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21678546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41506
BRD-K03675705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46455
1141_CAAP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.61342
BRD-K72648699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46576
GSE244710_3_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6524
BRD-K14255526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11302
GSE147056_2_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1815
BRD-K32862383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17929
GD-59-OG21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.364606
ANAPC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11679
ECGI10	DepMap CRISPR Gene Dependency	1.0	2.965
BAY 57-1293	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
BRD-K08702524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10337
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CALU6	DepMap CRISPR Gene Dependency	1.0	2.48617
AB-70-GR31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.512425
GSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0432
BRD-K90974935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53738
BRD-K02624724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15435
BRD-A94046266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95091
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Fluticasone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07869
PBRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.356
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1089
CHEMBL569227	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
CRCGN008_HEPG2_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1208
GSE151689_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_2_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K42557763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16626
SW1417_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.18967
GSE138001_0_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2633_EN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.582019
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE240896,GSE240899_10_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63383299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31628
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6151
PCI30	DepMap CRISPR Gene Dependency	1.0	2.1662
BRD-K84178323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9331
GBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3014
GSE210101,GSE210114_5_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K82877426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53011
BRD-K48860650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29827
AF-12-IW93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25663
BRD-K15123815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07499
HARA	DepMap CRISPR Gene Dependency	1.0	2.05463
GSE184892_4_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.363418
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ASAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1005
kasugamycin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71603
BRD-K47200630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14702
BICR10	DepMap CRISPR Gene Dependency	1.0	2.69429
BRD-K22508525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27737
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_9_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A85216385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12217
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K91216645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3817
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.19
RPL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16886
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.415406
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7871
BRD-K08489825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15711
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73355
RPE1SS6	DepMap CRISPR Gene Dependency	1.0	2.66305
BRD-K95935249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76525
GSE171175,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K42181022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.61563
CRCGN015_MCF10A.TP53.M_24H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09272
Finasteride	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
Syntrophin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.91
CRCGN010_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21248
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE220813_0_v_1_zfp750_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57382977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34517
ISCU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35825
NEPRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45848
MTA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33577
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6684
CORL105	DepMap CRISPR Gene Dependency	1.0	3.4709
HS944T	DepMap CRISPR Gene Dependency	1.0	3.13744
abnormal kidney morphology	MGI Mouse Phenotype Associations 2023	1.0	null
GSE242199_2_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EID3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34733
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3921
BRD-K07770425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09524
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SJSA1	DepMap CRISPR Gene Dependency	1.0	2.22186
BRD-K99638698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12224
BRD-A89038047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29549
2,4-Dichlorophenol	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1251
GSE216043_11_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.664891
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GPX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0394
BRD-K68512873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01088
BRD-K18000429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00424
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15853
GSE160246_0_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal skin morphology	MGI Mouse Phenotype Associations 2023	1.0	null
Senicapoc	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
BRD-K10911459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22067
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A47166394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57758
BRD-K26233698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91516
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
GSE214931_1_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DNAJC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12288
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3709
PMC6961462-NIHMS1544104-supplement-Sup_Tab.xlsx-Sup_Table_3_a-Supplementary_Table_3_Genes_Regulated_by_A_MYB_in_Humans_and_Macaques_Bold_genes_with_reduced_expression_in_Group_3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
COLO205	DepMap CRISPR Gene Dependency	1.0	2.21279
BRD-K09878843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.58578
BRD-K21253219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18264
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.0141
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64485
BRD-K60728944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72219
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.19192
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.273279
CALU6_LUNG	CCLE Cell Line Proteomics	1.0	2.25917
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76273
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K27226238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27592
HOXB5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8547
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MRFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94586
TMEM131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12797
DCAF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19618
GSE138672_0_v_1_rabgef1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04234
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23111
BRD-K53198140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32116
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXB7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2383
CEBPB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5723
GSE248858_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Testicular cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
abnormal skin morphology	IMPC Knockout Mouse Phenotypes	1.0	null
10799_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.5443
MCIXC	DepMap CRISPR Gene Dependency	1.0	3.265
BRD-K93044218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54355
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5917
BRD-K55218521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.12814
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.359753
BRD-K82064887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34342
GSE217873_1_v_2_nusap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
TGBC52TKB	DepMap CRISPR Gene Dependency	1.0	2.39927
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
5339_MTOR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.508184
NUBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07713
CRCGN016_MCF10A.WT.HP_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05518
BRD-A89846380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64842
CRCGN015_MCF10A_48H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09467
BRD-K94744294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4341
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112762,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K90697692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88198
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
decreased prepulse inhibition	MGI Mouse Phenotype Associations 2023	1.0	null
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8586
BRD-K32191695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62835
BRD-A54769817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5196
BRD-K20073772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02621
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HSSCH2	DepMap CRISPR Gene Dependency	1.0	2.77914
GSE128730_7_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12721900-jci-136-187998-s161.xlsx-Flag-ETS1_vs_vector-Gene_ETS1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86848211	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2557
BRD-K99681648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85511
EF-52-ML96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263737
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0224
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10391
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2436
BRD-K52001024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28342
GSE128730_4_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSTP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00413404
BRD-K59870481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49191
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAE 226	DeepCoverMOA Drug Mechanisms of Action	1.0	1.03
BRD-K80763723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08344
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386768
MFE296	DepMap CRISPR Gene Dependency	1.0	2.09495
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260038
L3MBTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28473
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dihydroergotamine-mesylate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81533
BRD-K50157358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60184
BRD-K85055578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10176
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.315522
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.887706
UBL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48348
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3149
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258441
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NLS-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE167886_2_v_0_chd7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0545
VPS72	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17736
GSE99687_3_v_1_smad5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67353973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5872
GSE149903_0_v_7_myd88_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.358421
GSE231799_2_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216273,GSE216292_14_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153189_2_v_0_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1189
CRCGN017_MCF10A.WT.HP_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0122
BRD-K99978187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45068
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76922696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25897
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5661
4-Methoxybenzoic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
PMC10882188-ADB-29-e13365-s002.xlsx-ST18-Unnamed_8_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
TRIFLUPERIDOL-2HCL	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.92215
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286757
GSE114284_2_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KB-46-EJ60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231518
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0741
ANKRD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36171
BRD-K30198800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7771
GSE217776,GSE217829_2_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02927989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40424
GSE128730_0_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1694	DepMap CRISPR Gene Dependency	1.0	2.66215
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE122425_1_v_0_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
tilmicosin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05595
BRD-K05041614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29023
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BE-27-RQ61_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346444
Salivary duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.838
BSX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0942
NR2E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00276
RAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06397
BRD-A58937872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.145
BRD-K64902833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72318
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69666
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3401
Pimavanserin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.39
BRD-K78714545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21358
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.402119
DDX39B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29932
IC-80-CT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.415922
DC-43-KF54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251445
UPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2454
BRD-K09108485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.72017
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236886
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
DPYSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61494
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K44167510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87413
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7778
GSE148200_0_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5640240-ppat.1006668.s013.xlsx-BETA4-379_common_elements_in_shEP400-1_BETA_shEP400-3_BETA_shMYCL_BETA_and_shEP400-2_BETA_BHLHE23	Rummagene Transcription Factor Associations 2026	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.52798
BRD-A50913845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07973
BRD-K63212062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71726
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.9206
ONCODG1	DepMap CRISPR Gene Dependency	1.0	2.75182
PMC12260418-pnas.2425984122.sd02.xlsx-TEAD1_6fraction_test_result-Unnamed_3_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal vitelline vasculature morphology	MGI Mouse Phenotype Associations 2023	1.0	null
MC-40-IP75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.530139
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	1.0	3.48622
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49305
TIMM13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38756
BRD-A19766589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55698
GSE180468_3_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RBE	DepMap CRISPR Gene Dependency	1.0	2.60597
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE214931_2_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K79072801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01454
DPRX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.332
ZNF263	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30434
GSE142210_4_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K49090949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.242
RPS9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617599
GSE140937,GSE140938_1_v_2_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.39618
BRD-K39244640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19783
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9764
Salmeterol	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.51
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
embryonic lethality prior to organogenesis	MGI Mouse Phenotype Associations 2023	1.0	null
ZNF384	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05368
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.2845
JHU022	DepMap CRISPR Gene Dependency	1.0	2.4126
GSE168171,GSE168173_0_v_1_ddx41_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SSTR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05034
952_NKAPD1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.636953
small kidney	IMPC Knockout Mouse Phenotypes	1.0	null
GSE125014_1_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.758984
PF-543	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.71
ZNF121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01714
HSPA1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677397
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27959
LO68	DepMap CRISPR Gene Dependency	1.0	2.0099
GSE153189_2_v_0_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147626_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
MM426	DepMap CRISPR Gene Dependency	1.0	2.284
pralidoxim	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04496
BRD-K38947493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58025
CACNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3872
GSE210476_2_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Rostral migratory stream	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.236
Creb3l2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.9336
KON	DepMap CRISPR Gene Dependency	1.0	2.23426
UMUC1	DepMap CRISPR Gene Dependency	1.0	2.15811
GSE235066_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE138001_2_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14216332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11569
GSE197850_4_v_0_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE163052,GSE163198_4_v_7_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100516_FWM_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.3653
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234673
SNU8	DepMap CRISPR Gene Dependency	1.0	2.09666
PMC8962202-Table2.XLSX-OCI-AML3_3_h-Differentially_modulated_proteome_in_OCI-AML3_cells_treated_with_CIGB-300_peptide_during_3_h_respect_to_non-treated_cells_p-value_0_05_and_FC_1_5_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HMGB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38077
BRD-A29578214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15061
BRD-K75821161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16656
GSE134375_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K38975326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03227
BRD-K48129913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72526
URB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.061
ZCCHC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24675
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K03848296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19023
BRD-K16411174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02307
BRD-K06208863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35575
RPS3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46345
BRD-K92269212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43687
BRD-K17395396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01732
GSE169590_6_v_1_rptor_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CEP170B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04693
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K74705119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0379
BRD-K60257691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47613
BRD-K90797575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62864
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9908
OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.68762
BRD-K41289356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42557
CRCGN014_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30387
MRFAP1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15774
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
1441_CDK7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.540334
BRD-K90697690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53276
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3856
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CEBPE	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5516
BRD-K40697889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68309
BRD-K27374902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01093
GSE242290_1_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6418
HOXA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1657
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.094
BRD-K82671459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07466
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22103
RABEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0462
P30OHK	DepMap CRISPR Gene Dependency	1.0	2.69914
ACP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07451
Lasmiditan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2533
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216655
abnormal visceral yolk sac morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K30782795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11611
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506158
POLR1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31844
BRD-K56075657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89285
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
RPS27L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05836
GSE202198,GSE202199_1_v_0_hmg20a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100462_PCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.61163
EIF2B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69131
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SSP25	DepMap CRISPR Gene Dependency	1.0	2.08259
BRD-A91712064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22553
CRCGN015_MCF10A.TP53.M_24H:D03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93048
GSE48812_4_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
emetine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19254
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26375
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BE-27-RQ61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209697
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MOGGUVW	DepMap CRISPR Gene Dependency	1.0	2.30272
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.08746
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2878
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.513632
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.49612
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8366
CRCGN017_MCF10A.WT.HP_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1724
BRD-K75036062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72754
GSE171175,GSE171181_1_v_0_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K95854766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56806
PATU8988S	DepMap CRISPR Gene Dependency	1.0	2.14862
GSE137144_4_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.752125
CRCGN011_HEPG2_24H:F08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0976
5447_NADSYN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.790761
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.95879
CRCGN016_MCF10A.WT.HP_24H:A15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46392
ABCA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2641
BRD-K96737756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04078
BRD-K72636868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55203
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Cerdulatinib_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149339
GSE158834_2_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE110708_0_v_3_adar_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pheochromocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.435
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.45762
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JL1	DepMap CRISPR Gene Dependency	1.0	2.35333
BRD-K07615667	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47953
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K77272277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06656
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCCPAN2	DepMap CRISPR Gene Dependency	1.0	3.33014
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
THO complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.944
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86845618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30932
GCIY	DepMap CRISPR Gene Dependency	1.0	2.25742
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K31606237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27366
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.042
IBA57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38436
BRD-K68257399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45653
Colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NAT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01344
GSE189653,GSE203344_2_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Rifaximin	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
GSE249544,GSE249637_6_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dicumarol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
GSE216043_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75074041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35541
EE-32-EY37_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.403937
BRD-K36848506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18587
BTBD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24295
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257088
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.879
BRD-K32173944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28483
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04527
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TRIM25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35406
DSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17428
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.755227
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8876
BRD-K64860758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47374
ED-71-GA72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.428055
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.797116
BCS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83064
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
KA-71-CQ35_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.372808
BRD-K19390761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22284
GSE239747_2_v_3_lrp6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cinchophen	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22187
BRD-A25243629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29861
MEOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0985
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_unique_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A95207036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49163
GSE118794_2_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10247733-41408_2023_863_MOESM4_ESM.pdf-600-ZNF174_ZNF174	Rummagene Transcription Factor Associations 2026	1.0	null
GSE171837_1_v_2_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE22255_DE-Genes_NOT_Autophagy_NOT_GSE66724_DE-Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.01322
BRD-K24748087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64703
BRD-K58324650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96503
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100466_PCx_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.29513
GSE190761_0_v_1_samd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE80537_0_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.67857
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.867832
Colon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:L17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0278
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_WT-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61247793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6802
BRD-K97707303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75507
abnormal vitelline vasculature morphology	IMPC Knockout Mouse Phenotypes	1.0	null
PARP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1474
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.50479
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.16161
OVCAR5	DepMap CRISPR Gene Dependency	1.0	2.5502
APMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09581
CRCGN016_MCF10A.WT.HP_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08599
BRD-K95820322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13756
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6619
QB-42-MC63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322679
2983_FAU_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.512759
ICC15	DepMap CRISPR Gene Dependency	1.0	3.06547
BRD-K84522516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03975
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8867
COL6A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.80528
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278556
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11615365-41467_2024_54246_MOESM6_ESM.xlsx-KK47-Numb-KD_vs_Ctr-KD-ensemblGeneId_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HOXB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7737
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5772
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.499552
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.8555
CRCGN014_HEPG2_3H:N08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27295
GSE154197_1_v_0_ints13_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92827116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28274
BRD-K74537058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61059
WM88	DepMap CRISPR Gene Dependency	1.0	2.66125
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385585
TSPAN13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17934
GSE86507,GSE86509_7_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE149264,GSE149267_9_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FZR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06339
LHX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1912
COV413A	DepMap CRISPR Gene Dependency	1.0	2.43759
GSE217452_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
8666_TAF5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.519728
GSE224970,GSE224971_1_v_0_sap30_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CARMIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05381
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
9311_TRMT44_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.700483
PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.48744
GB1_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.79809
PMC6080909-JEM_20171312_TableS1.xlsx-miR-196_predicted-Table_S1_miR-196a_b_predicted_targets_by_PITA_PicTar_TargetScan_and_DIANA_prediction_algorithms_ZFP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE239844_1_v_5_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE165334_2_v_0_dabrafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_ZSCAN4-Unnamed_1_ZSCAN4	Rummagene Transcription Factor Associations 2026	1.0	null
ANXA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0688
BRD-K75136523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14969
GSE186287_2_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28720546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20954
BRD-K23162766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5869
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1847
MNX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4338
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.83546
GSE241036_0_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5967331-41467_2018_4384_MOESM4_ESM.xlsx-Sup_data1_with_CCF_txt-Gene_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K80332123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12729
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239868
PMC10274973-media-3.xlsx-ST18-Supplementary_Table_18_476_Bonferroni_significant_results_P_2_67_x_10-6_of_gene_based_association_analyses_H-MAGMA_dlPFC_cortical_neurons_for_sensation_seeking_factor_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135350_3_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
4985_METAP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15975
AA-62-OC45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210866
VAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2665
BRD-K37850190	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62435
CRCGN017_MCF10A.TP53.M_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15395
FF-90-JK74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308656
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.0347
GSE102269_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FA-92-JL46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.816113
RPS6KA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06778
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.775378
Osilodrostat	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
SCC9	DepMap CRISPR Gene Dependency	1.0	2.12183
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MED15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38176
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207676
Prinomastat	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
BRD-K27092365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1476
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.673
PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3843
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275206
GSE147056_0_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1376
BRD-K50413145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.46939
BRD-K46820725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05982
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0244
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.20485
GSE48812_7_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Zonisamide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2862
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mirabegron	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
Glycyrrhizic acid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.31
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CLINDAMYCIN-PO4	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40278
CRCGN016_MCF10A.TP53.M_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15098
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.10228
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
537_ARPC3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.506755
BRD-K01973494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42929
BRD-K96054771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62166
TO14	DepMap CRISPR Gene Dependency	1.0	2.36018
Paraganglioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.618
BRD-K99250186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34856
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294028
CRCGN015_MCF10A_48H:F12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16105
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
KPNA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48612
GSE102505_4_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K74948793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11985
FUBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53465
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1769
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.10833
BRD-K25304254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04435
HARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32009
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
LD-37-JE11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282334
CRCGN015_MCF10A.WT.HP_24H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42981
BRD-A08191729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0876
CRCGN017_MCF10A.WT.HP_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1728
SNU1	DepMap CRISPR Gene Dependency	1.0	3.12488
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10205
ZDHHC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01986
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6312
TMEM107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78639
HOXB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8422
BRD-K88449712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04358
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE171572_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6275
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	34.816
GATA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5514
CRCGN011_HEPG2_24H:J13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0023
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.42636
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
RETREG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02478
UFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42202
Peripheral nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368017
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K84128738	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97776
CASTOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56833
BRD-K12640996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05387
BRD-K76193256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47904
GTEx Muscle 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-14.2916
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.763
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6831
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205550,GSE205552_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MRE-269	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.38
BRD-K10684867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46235
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.9266
BRD-K48533326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07779
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CFP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50193
GSE223008_11_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
Bexarotene	DeepCoverMOA Drug Mechanisms of Action	1.0	0.44
BRD-K26508889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95029
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230744
BRD-K89744662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18745
1148_CACTIN_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.532574
CRCGN008_HEPG2_24H:C17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74905
Ebf2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.8188
GSE122215,GSE122217_0_v_4_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197562_0_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LN229	DepMap CRISPR Gene Dependency	1.0	3.10314
BRD-K15387690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07957
GSE195663_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
9713_VCX_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.551152
CRCGN015_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.10005
BC-63-DM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.458024
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46438
AGPAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15131
GSE137818_3_v_7_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9170563-12885_2022_9665_MOESM3_ESM.docx-0-Candidata_target_genes_of_CEBPB_1_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205163,GSE205164_9_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
H103	DepMap CRISPR Gene Dependency	1.0	2.21551
HOTHC	DepMap CRISPR Gene Dependency	1.0	2.23022
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.8916
canthaxanthin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07649
APC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05079
BRD-K06237859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04864
SH3GLB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63456
BRD-K32451879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16857
PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31720099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35702
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23405
RIOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14777
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDAMB436	DepMap CRISPR Gene Dependency	1.0	2.41745
BRD-K60255752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42031
HLA-B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11256
MB-49-LL22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229322
BRD-K17606413	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07648
BRD-K04731905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1621
HC-76-PX74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377322
BRD-K94637240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5168
GSE216043_7_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K49570068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27112
CB-44-RT90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237215
RPE1SS119	DepMap CRISPR Gene Dependency	1.0	2.40116
BRD-K29298614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25689
EC-07-AO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23793
BMS309403	DeepCoverMOA Drug Mechanisms of Action	1.0	0.42
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.326701
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.908
LIVF001-015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22324
hydroxyprogesterone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48044
BRD-K77578964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07789
GSE214931_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K34620971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07461
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE159678_4_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ADRA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10699
BRD-K60272064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54398
Diethylstilbestrol	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.22
BICDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32595
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08561
Sympathetic chain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.145
ZNF35	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.109
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TR146	DepMap CRISPR Gene Dependency	1.0	2.43952
MPZL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81291
HC-63-SV27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260113
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3916_HOXC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.516065
BRD-K37328981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08548
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79697020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15671
BRD-K84761515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17565
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K90951880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83235
GSE144115_4_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2931
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.0859
TE11	DepMap CRISPR Gene Dependency	1.0	2.28506
Uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LMX1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9226
increased freezing behavior	IMPC Knockout Mouse Phenotypes	1.0	null
496100406_HIP_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12973
BRD-K30963311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07777
BRD-A99445203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70517
GSE125782_0_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
TD-69-UA90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215587
BRD-K76661445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24042
GSE184884_2_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00486305
GJC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29943
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.217018
BRD-K29211776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21422
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9852
A1BG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31243
BRD-K10058823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20417
BRD-K44799944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27671
GSE203158_12_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
1872_CRIM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.565008
DC-51-WE27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216217
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221826
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2394
BRD-K86491317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06194
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_9_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8335
BRD-K92569554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07648
BC-61-BE07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.524577
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263015
Npas2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.7345
NZM7	DepMap CRISPR Gene Dependency	1.0	2.30144
BRD-K00611112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19951
BRD-K50094173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19532
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K38244121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14023
BRD-K49473928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68788
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7075
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_1_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE243491_1_v_2_oxaliplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10552
URB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19505
BRD-K80880506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0499
GSC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4725
CRCGN013_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00958
BRD-K21662756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17927
BRD-A90450579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40348
CB-16-SY72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23712
GSE240896,GSE240899_2_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50655333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26347
BRD-K92544320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1409
BRD-K92981306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39071
BRD-K35122752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27344
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.36066
UTP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90841
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.305
CD-16-KY17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317303
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6801
5339_MTOR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.562918
GSE112760,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0445
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6017
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC6138639-41467_2018_6247_MOESM4_ESM.xlsx-S1_2_ZZZ3_occupied_genes-ATAC1_bound_genes_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K26872015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19903
BRD-A33119430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15742
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2673
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171572_3_v_4_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.18813
HOXB8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1584
CRCGN010_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13053
PRPF39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10642
abnormal visceral yolk sac morphology	IMPC Knockout Mouse Phenotypes	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11345
ZSWIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03208
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
BRD-K62202988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40261
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K09191014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62333
BRD-K75999096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.66942
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.44825
VAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.282
496100397_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.18811