association	dataset	threshold value	standardized value
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_19_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14255526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53997
Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NG-01A-31R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12824906-mmc5.xlsx-Sheet1-Table_S4_Target_genes_of_FOXM1_and_their_expression_across_the_subtype_of_breast_tumors_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K43496057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32906
BRD-K52932858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19149
MESSA	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47574
CANT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72024
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43148
TRMT1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0111
SG in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.99705
DNAJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24412
TFIP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81218
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.01649
CardiacMyocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.2603
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.90175
Skeletal muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.648
BRD-K72255288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5082
Brain Lower Grade Glioma_LGG_TCGA-HT-8010-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRPL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6804
OVCAR-8	GDSC Cell Line Gene Expression Profiles	-1.0	-1.91713
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.953189
CLK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69113
TXNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24028
GTEX-X585-0426-SM-4E3JZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880053
H3K27me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5442-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.95024
UBE2H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58068
defense response to virus	GO Biological Process Annotations 2023	1.0	null
BRD-K51298794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43817
CRCGN015_MCF10A.WT.HP_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21434
SF767	CCLE Cell Line Gene Expression Profiles	-1.0	-2.80025
BRD-K28467592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12357
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895591
betamethasone-dipropionate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48321
LIPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0767
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.645899
BRD-K25013674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43495
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01631
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EB-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26395018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35279
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.692
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.9549
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4142
NUBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81381
HOXD13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82436
osteogenic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.15441
gh3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.250627
myometrial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.331194
primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01208
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.85801
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.47442
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HELB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56073
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75822
hippocampus (hippocampal formation)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38562
BRD-K26976202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.63014
GRHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2013
MCU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73707
cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
DLX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73129
BRD-K44520987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22891
Crus I, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2211
fashion	GeneRIF Biological Term Annotations	1.0	null
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.1998
diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.133078
CRCGN015_MCF10A_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.619
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.95191
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respiratory Tract Diseases	CTD Gene-Disease Associations	1.0	1.0766
LRATD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82559
BRD-K69661816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20843
ZDHHC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00998
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J9-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GPCRs, Class A Rhodopsin-like(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
SUPT3H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95663
GPCRs, Class A Rhodopsin-like(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05469
Sarcoma_SARC_TCGA-DX-A8BU-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1135
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.85663
substantia nigra, pars reticulata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.840432
B3GNT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00777
GSE244072_10_v_7_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70717477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.4489
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26148
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5626
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CH-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.901989
female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042701
integral component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.559285
TOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00749
Trabecula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.621
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3423
CRCGN016_MCF10A.WT.HP_24H:D04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.0096
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.93893
dorsalstriatum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.925017
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.59817
ICC137	DepMap CRISPR Gene Dependency	1.0	7.0279
SUM159PT	DepMap CRISPR Gene Dependency	1.0	2.36671
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26C-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc_7Hour_None_GSE43204	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.56345
GNL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51225
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-6148-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCM-460 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.832
CRCGN015_MCF10A_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.01555
HNF1A_OE_GDS1499_252_human_HEK293 embryonic kidney cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
Myoclonic Epilepsy	DisGeNET Gene-Disease Associations	1.0	null
SW954	DepMap CRISPR Gene Dependency	1.0	3.53084
GTEX-VJYA-1426-SM-4KL1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28786
brain microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.38439
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.623
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SK-MEL-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.38727
PMC9843885-40478_2023_1507_MOESM6_ESM.xlsx-CIC-OE_TS603-Unnamed_1_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM120B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15158
Peptide GPCRs(Mus musculus)	WikiPathways Pathways 2014	1.0	null
AR	ChEA Transcription Factor Targets	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.268137
fallopian tube	HPA Tissue Gene Expression Profiles	1.0	1.43804
morphine_mus musculus_gpl6105_gds3703	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BT20	Achilles Cell Line Gene Essentiality Profiles	1.0	1.19089
ORC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47841
YBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73815
GTEX-NL4W-0011-R8a-SM-2I3G4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960484
Sarcoma_SARC_TCGA-KD-A5QT-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.553683
BRD-K64698855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14064
TIMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42232
TE-671 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.517
EFHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62874
RASAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4037
PI4KA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26115
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1161
Adrenocortical carcinoma_ACC_TCGA-OR-A5JR-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1876	CCLE Cell Line Gene CNV Profiles	1.0	2.0416
BRD-K71420819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03062
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.474258
GTEX-XGQ4-2026-SM-4AT6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59085
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4763-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
osteoclast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.367689
STAT3-24763339-IMN-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.745578
vascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07311
CRCGN017_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33797
Dense core granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.764
CRCGN009_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23217
reticulotegmental nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02707
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XUJ4-2726-SM-4BOQ1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987452
Lung squamous cell carcinoma_LUSC_TCGA-22-5471-11A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CPOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92287
ZNF143	ENCODE Transcription Factor Targets	1.0	null
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	151.293
Prostate adenocarcinoma_PRAD_TCGA-CH-5743-01A-21R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K51568355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7075
transmembrane signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.42699
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.959493
TMEM126A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94286
SUDHL8	CCLE Cell Line Gene CNV Profiles	1.0	1.98731
BCAP31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29652
COLO783	Achilles Cell Line Gene Essentiality Profiles	1.0	1.58482
positive regulation of leukocyte proliferation	GO Biological Process Annotations 2023	1.0	null
FAM229B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36259
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-ENSEMBL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.39333
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48603
H3K27me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.79723
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.39984
HAND2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39704
NECTIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17569
NCI-H69 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.665
[Phe<sup>13</sup>]bombesin	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
BRD-K25269762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35609
Metencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.063
CXCL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90531
Mesothelioma_MESO_TCGA-SC-A6LM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K28583191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30979
SKM-1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
amphetamine_rattus norvegicus_gpl6101_gse31081	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.46766
NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0738
GTEX-XPVG-1526-SM-4B66C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952652
MAP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70969
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89454
REST_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AGS	GDSC Cell Line Gene Expression Profiles	1.0	1.57165
L-540	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51118
Myometrial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.422
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CAPN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72212
NCIH211	CCLE Cell Line Gene Expression Profiles	-1.0	-1.95101
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9948
MPHOSPH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00714
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71184
gastrin releasing peptide (14-27) (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
CRCGN015_HEPG2_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	10.0
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.06207
SLC25A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4549
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.68
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.67329
MKN45	CCLE Cell Line Gene CNV Profiles	1.0	1.6141
HOXB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.32092
SH3GLB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88996
ZFP37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06772
CAL51	Achilles Cell Line Gene Essentiality Profiles	1.0	1.20458
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01433
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13724
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K36697652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.76926
FOXO3-23340844-DLD1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923939
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5115-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856112
Acute Myeloid Leukemia_LAML_TCGA-AB-2983-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
ATG4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41536
BRD-K47417426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53414
Central amygdaloid nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.821
GTEX-R55D-0126-SM-48FEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06436
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39583
Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PDGF_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
BRD-K36736230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75537
ACOT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24433
rostral putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.955409
SW1417	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.01493
GTEX-PWO3-0011-R5A-SM-2I5EZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21274
pioglitazone_mus musculus_gpl1261_gds4413	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FAM43A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37521
tanespimycin-5586	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GATA2-21186366-BM-HSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7752
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
U-118-MG	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pars intermedia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.674
BRD-K50177754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1942
CRCGN009_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46293
signal transducer activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K44779670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49986
REST_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.4296
BLACAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77476
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23163
TMEM39B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43601
HNF1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1412
CRCGN013_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97445
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.089909
GATA3_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MK-5046	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.00109
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QV-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31536
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.1039
PLA2G4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23469
SP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01093
LRRC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09783
SUZ12-20075857-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
REST_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLIC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06621
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.03265
BRD-K34343777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26813
NCI-H1836	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HEXIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56813
dorsolateral prefrontal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08984
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.924843
MBTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93107
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8063
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48659
EGFR_OE_GDS1925_167_human_Estrogen receptor (ER) alpha positive MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GUSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42976
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A77P-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32292
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
OCILY19	CCLE Cell Line Gene CNV Profiles	1.0	1.38184
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4303
DNAJC28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00397
CHL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.12362
Cytoplasmic side of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.233
Brain Diseases	CTD Gene-Disease Associations	1.0	1.12668
Sarcoma_SARC_TCGA-KD-A5QU-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8498
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.02022
BRD-K54151058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.147
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.525
CRCGN016_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57332
POLL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.25083
vorinostat_homo sapiens_gpl570_gse34880	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EW16	DepMap CRISPR Gene Dependency	1.0	3.4462
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4623
ZNF705B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.89438
BRD-A68797623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25826
EGR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98549
Prostate adenocarcinoma_PRAD_TCGA-G9-6356-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXP1_01_208	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61254
BRD-K00717406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58113
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48659
NCIH1437	DepMap CRISPR Gene Dependency	1.0	2.36715
IZ in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00427
X-organ-sinus-gland complex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.751
RCOR1	ENCODE Transcription Factor Targets	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.94211
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
REST_Panc1_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NC-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pancreatic cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.226926
EMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18076
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4973-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040342
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952293
PCSK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37141
BRD-K63957636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2204
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.9732
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EI-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K45717258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20933
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.331927
GSE148066,GSE157787_11_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hutu80	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.624
HEATR5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96706
DGKE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3781
H3K27me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83954
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.8069
DMRTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34985
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
FAM8A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87953
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN008_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.465
Intercalated nucleus of amygdala	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.9072
Prostate adenocarcinoma_PRAD_TCGA-HC-8260-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98969
FOXO3-23340844-DLD1-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
ISTMEL1	DepMap CRISPR Gene Dependency	1.0	3.17112
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.44317
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K38403252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20788
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04871
BRD-K42081955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33739
Pars distalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.954
TFPI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52882
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	CTD Gene-Chemical Interactions	1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NMB	Guide to Pharmacology Protein Ligands of Receptors	1.0	null
blood vessel endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065859
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.929439
PMC8160578-JCB_202009147_TableS4.xlsx-FOXM1_targets-Genes_n_696_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-3394-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Preoptic area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.071
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.67
H3K9me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SESTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80054
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067227
lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.747102
Lung adenocarcinoma_LUAD_TCGA-49-6745-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C1orf54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93747
REST-19997604-NEURONS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K30071505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44463
prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.258064
KMT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31571
BRD-K65257143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.65543
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4656
BRD-K94936556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56781
BRD-K76508844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39162
786	BioGPS Cell Line Gene Expression Profiles	1.0	0.880564
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58596
neuroendocrine tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.161139
HAUS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7184
Acute Myeloid Leukemia_LAML_TCGA-AB-2985-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.089
pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.340388
H3K27me3_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_iPS-20b	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TRMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9685
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.838242
POLR2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90446
Kidney Chromophobe_KICH_TCGA-KL-8339-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80993
BRD-K56520530	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35205
SOX6-21985497-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48301
BRD-K49630774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49361
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
light-harvesting complex, core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.759
GPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45851
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.358919
Peptide ligand-binding receptors	Reactome Pathways 2024	1.0	null
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78551
CRCGN016_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.76178
respiratory mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.146956
CRCGN016_MCF10A.WT.HP_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8818
BHMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9015
C1QBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92318
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4703-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.52069
phenazopyridine-5758	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Chronic obstructive pulmonary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.671
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.00676
CCNY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02165
AIMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45792
[D-Phe<sup>6</sup> &beta;-Ala<sup>11</sup> Phe<sup>13</sup> Nle<sup>14</sup>]bombesin-(6-14)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
GSE152937_12_v_1_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873272
GPCR ligand binding	Reactome Pathways 2014	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-7658-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K12836153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31294
BRD-K68312794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39088
positive regulation of type I interferon production	GO Biological Process Annotations 2023	1.0	null
GTEX-PWO3-0011-R8A-SM-2I5GD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21164
BRD-K83697352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1326
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36074
lansoprazole-6009	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44454
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.85595
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Intrinsic component of presynaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.823
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6221-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO 206F	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.915255
D-Nal Cys Tyr D-Trp Orn Val Cys Nal-NH<sub>2  </sub>	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01704
NUP43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65313
CCK81	CCLE Cell Line Gene CNV Profiles	1.0	2.12755
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.21853
Obstructive lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.671
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2GZ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8333
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2505
Peptide GPCRs	WikiPathways Pathways 2024	1.0	null
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4585
TSC22D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81722
NPIPA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79092
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18008
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1784
CEP135	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8198
Adrenocortical carcinoma_ACC_TCGA-OR-A5LN-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KCNIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.92743
GTEX-WFJO-1126-SM-4LVLZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1
Sepsis_Splenocyte_GSE4479	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.34641
ZNF154	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48778
CDH4-35650610-MESC-MOUSE-STEM-AUTISM	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-NPJ8-0011-R9a-SM-2YUN5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44071
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A86F-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19641
REST	ChEA Transcription Factor Targets	1.0	null
primary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.186393
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1117
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16366
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1655
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7681
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.15695
SIN3A	ENCODE Transcription Factor Targets	1.0	null
EXOC3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49826
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.846778
Cardiovascular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.877
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.11778
BRD-K36643302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51223
SMAD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74283
GTEX-PLZ5-1526-SM-3P5ZX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10894
glioblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.753297
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.22756
CHL1DM	DepMap CRISPR Gene Dependency	1.0	2.03663
OLIG3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7675
Granulomatous Disease, Chronic_Blood neutrophil_GSE935	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.46879
BRD-K26954192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81213
Sarcoma_SARC_TCGA-FX-A3NK-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tracheal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.76
CIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30734
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18358
positive regulation of respiratory gaseous exchange	GO Biological Process Annotations 2023	1.0	null
NR3C1-21868756-MCF10A-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K16976282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34289
BRD-K22039769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2
swiss-3t3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.546533
BRD-K89338336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13876
EDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67639
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC27A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32612
Small Cell Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
KDELR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53265
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.4816
BRD-A20208638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07784
H3K9me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6N0-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5252
COLO-678	GDSC Cell Line Gene Expression Profiles	1.0	2.10949
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27398
UNC45A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62199
LDOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32933
FBH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97218
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.54803
CRCGN017_MCF10A.WT.HP_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3131
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-8195-01A-31R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084994
BRD-K76833108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14131
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.90693
KYM1	DepMap CRISPR Gene Dependency	1.0	6.64687
PMC8638098__F6	PFOCR Pathway Figure Associations 2024	1.0	null
CW2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.95632
GTEX-T6MN-2026-SM-4DM7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81791
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5549-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
myometrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.662336
MK-5046	DGIdb Drug Targets 2026	1.0	0.8822
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.30801
JHH7	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76588804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11798
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.64905
HUP-T3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920553
BRD-K74382273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32634
BRD-K20185935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04056
BCAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27404
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.979748
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.671
H3K27me3_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MIER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50388
PMC6555970-40246_2019_210_MOESM1_ESM.xlsx-LF_genes_R_genes-Common_genes_in_all_LF_species_not_found_in_common_genes_of_R_species_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K78337983	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36873
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN013_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63492
H3K27me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K50443235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12348
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6955-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
prostate cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.372369
NCIH1838	CCLE Cell Line Gene Expression Profiles	1.0	1.55299
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03204
BRD-K04928505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91772
BRD-K13970506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37009
ZNF100	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39728
FOXA2	ChEA Transcription Factor Targets	1.0	null
BRD-K66941670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24972
HTR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57928
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-SYMBOL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
PAPOLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50305
BRD-K93900188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83533
BRD-K29466595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14854
BRD-K61623863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95677
RAMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21296
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KCIMOH1	DepMap CRISPR Gene Dependency	1.0	3.55116
BRD-K74129999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93203
NUGC3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.62338
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59922
BRD-K08458391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00297
BRD-K01022714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33499
BRD-K37283718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09841
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19578
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K77483143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53471
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3829
CRCGN012_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15926
GTEX-QVUS-0011-R6A-SM-3GACX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07385
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5988-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24156533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44192
PMC8995879-Table_1.xlsx-exome_variants_MAF_0_01-Gencode_34_hugoSymbol_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X585-0011-R4B-SM-46MVH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921198
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
Brain Lower Grade Glioma_LGG_TCGA-DU-8164-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47682
pituitary gland tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.142546
Lung adenocarcinoma_LUAD_TCGA-38-4625-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IJ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55679243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27036
ARHGDIB_Transfection_GDS4455_551_human_UM-UC-3 bladder carcinoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Diphtheria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.13
CRCGN012_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71164
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7331-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OLIG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7522
BRD-K16754572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43327
cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085415
BRD-K10171338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50331
TM-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.18
BRD-K20091931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36022
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8258
smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.22797
CRCGN016_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.65791
G protein-coupled receptor heterodimeric complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.522
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
glial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.73803
posterior group of nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.04301
DAZAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89667
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.7
CRCGN014_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.45771
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.79115
intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.12298
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.913015
BRD-K71778797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40712
CRCGN014_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49437
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62725
infratentorial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.065358
BRD-K51515697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20024
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.24705
MAZ	ENCODE Transcription Factor Targets	1.0	null
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.70789
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4ND-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ampulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.771
Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5567-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45935
striatum_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.1213
MAFK_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
OAZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27025
OV-7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Adenoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.522
BRD-K21610715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29953
PITHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5925
GTEX-RU72-0011-R8A-SM-2TF61	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858505
TCF12	ENCODE Transcription Factor Targets	1.0	null
CRCGN013_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.27626
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
BRD-K15433418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08341
Weight Loss	HuGE Navigator Gene-Phenotype Associations	1.0	null
FOXM1-26456572-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
primary motor cortex (area M1, area 4)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.8636
esr2_15280152_c57bl6_mice_soleus_skeletal_muscle_lof_mouse_gpl81_gds791	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.957427
Acute Myeloid Leukemia_LAML_TCGA-AB-2845-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.419623
Prostate carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866663
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RBM12B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69398
CRCGN014_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62045
RCBTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33828
Brain Lower Grade Glioma_LGG_TCGA-HT-7874-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-EGR1_DC_ChIP-seq_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
GDF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86365
BRD-K67832115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05072
Prostate adenocarcinoma_PRAD_TCGA-EJ-7794-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.99567
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CSNK2A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86025
Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
MHH-NB-11	GDSC Cell Line Gene Expression Profiles	-1.0	-1.89147
HNT-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26967
CRCGN014_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.53435
ABCF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31014
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877759
TRAM1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14098
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.7114
Brain Lower Grade Glioma_LGG_TCGA-E1-5302-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE203308_6_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NAIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41121
BRD-K67120755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48686
POLR2AphosphoS5_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K01639528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61546
DPP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5964
MOV10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80999
GSE216757_4_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
EPHA7	MSigDB Cancer Gene Co-expression Modules	1.0	null
PANC0327	DepMap CRISPR Gene Dependency	1.0	3.72778
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.883509
Pain agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
KALS1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.68579
cingulate gyrus, retrosplenial part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00489
Gastrinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.496
Peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.381
FAM193B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34856
DAOY cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.071
cortico-medial group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.06591
core of nucleus accumbens	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4841
intestinal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.187008
[<sup>125</sup>I][Tyr<sup>4</sup>]bombesin	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10684
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7733
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
12406872-Table4	GeneSigDB Published Gene Signatures	1.0	null
GTEX-V955-1926-SM-4KL1L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35246
RBBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77478
ChIP_SUZ12_16625203	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
HNRNPC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88249
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8387
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9954
ZSCAN31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30356
DNAJB12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46201
Lung adenocarcinoma_LUAD_TCGA-J2-A4AG-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autosomal dominant intellectual developmental disorder 41	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
SNU-C5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sarcoma_SARC_TCGA-FX-A76Y-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
COA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42594
H3K4me1_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD3OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74774
BRD-K87340219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54778
Brain Lower Grade Glioma_LGG_TCGA-HT-7854-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUDUL1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41028
SG in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11614
TAMALIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61568
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6026
M059K	CCLE Cell Line Gene CNV Profiles	1.0	1.37031
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6026
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LC-1-SQ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.0175
posteroventral (inferior) parietal cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.8471
Lung squamous cell carcinoma_LUSC_TCGA-43-5670-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Mammary Neoplasms	DisGeNET Gene-Disease Associations	1.0	null
dms273	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.512
behavior/neurological phenotype	MPO Gene-Phenotype Associations	1.0	null
BRD-K53720386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90453
BRD-K76449854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69341
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18984
BRD-K66973998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.61178
FBXO9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27396
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69545
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49499
outer CP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.993273
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5094-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.085752
RNASE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33372
Peripheral ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.317
Leydig cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.171
S100A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37387
mediodorsal nucleus of thalamus_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13723
BCP1	CCLE Cell Line Gene Expression Profiles	1.0	1.41783
ES-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	Reactome Pathways 2014	1.0	null
BRD-K82521348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05675
BRD-K80467627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02831
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.648
PROSER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86572
AR-22383394-PROSTATE_CANCER-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K64469421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22698
BRD-K13873561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89756
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.55307
antiviral innate immune response	GO Biological Process Annotations 2025	1.0	null
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K71671197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26817
ZFAND3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57956
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PAXIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18825
NCI-H838	GDSC Cell Line Gene Expression Profiles	-1.0	-1.47605
CRCGN012_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.31475
GTF2IRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19887
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7327
CRCGN012_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48245
Brain Lower Grade Glioma_LGG_TCGA-HT-7602-01A-21R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NMS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.084
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10273
CRCGN014_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.07445
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.0697
LEMD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42314
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38172
GTEX-S7PM-0626-SM-4AD4Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50561
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58461
haloperidol-2663	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.599273
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.306
posteroventral (inferior) parietal cortex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.71595
GTEX-OIZH-1526-SM-3NB1J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826384
SIRT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1998
GSE213228_4_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Height	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
496100609_TCx_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03109
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98253383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09518
BRD-K25103635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04535
PPARD	ChEA Transcription Factor Targets	1.0	null
EZH2_DEPLETION_GDS2445_117_human_embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PMC3470785-NIHMS377161-supplement-3.pdf-421-HOXB1_HOXB1	Rummagene Transcription Factor Associations 2026	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.23392
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A6DV-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PCBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00989
BRD-K56470219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23704
GSE142210_11_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5391
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.795
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5496
PMC10928104-41419_2024_6576_MOESM4_ESM.xlsx-S14-MYBL2_targets_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7246
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.54623
furan	CTD Gene-Chemical Interactions	1.0	null
reuniens nucleus (medioventral nucleus) of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.898878
DGKZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03253
B875 antenna complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.759
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44645
PMC8567280-EMBR-22-e53014-s008.xlsx-PC3_TIP5_bound_promoter-Unnamed_4_BAZ2A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2797
PLBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27447
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.89324
CRCGN014_HEPG2_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31239
NUMA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53373
CEBPD-21427703-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39885
metencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.365633
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.162
SARS-CoV MA15_Day2-PFU-10^4_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.6493
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6283
PDIA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4813
Lung adenocarcinoma_LUAD_TCGA-NJ-A55A-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A4TM-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76980944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41755
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
600MPE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.921481
colonic	GeneRIF Biological Term Annotations	1.0	null
FXYD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96211
colonic epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.200306
spanning component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.621804
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02393180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3822
abnormal body temperature homeostasis	MGI Mouse Phenotype Associations 2023	1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Osteoclastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.15
GSE142684_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pretectal region	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05977
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.883684
FOXA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15058
COLO704	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.13112
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914343
LUZP1-20508642-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GNRH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69558
BRD-K30656344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64148
SU-DHL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PLAAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6358
SKOV3	BioGPS Cell Line Gene Expression Profiles	1.0	1.23706
D341MED	CCLE Cell Line Gene Expression Profiles	1.0	1.67862
Prostate adenocarcinoma_PRAD_TCGA-KK-A8IH-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adrenal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.943
GTEX-TSE9-0011-R6A-SM-3DB7L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957909
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2839-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
they	GeneRIF Biological Term Annotations	1.0	null
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.18618
SLC25A32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20823
ZNF337	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98863
BRD-K70751829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50661
DNM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18047
BRD-K78003637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43426
cefalotin-6079	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.39759
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.61269
MS751	DepMap CRISPR Gene Dependency	1.0	2.86841
BRD-K40251180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54422
Neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.214
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12601
GTEX-N7MS-0011-R4a-SM-2HMKW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949348
Paraventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.182
GATA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9727
NCIH650	CCLE Cell Line Gene CNV Profiles	1.0	1.38335
USP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21003
PMC6501765__F2	PFOCR Pathway Figure Associations 2023	1.0	null
TMEM123	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.56253
POLR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14782
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.73926
H3K4me1_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
496100408_PCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.31329
BRD-K17421394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07278
SPRED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90627
GI1	CCLE Cell Line Gene Expression Profiles	1.0	1.73638
medulloblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.426109
Brain Lower Grade Glioma_LGG_TCGA-S9-A6UB-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9957
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09492
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
positive regulation of type I interferon production	GO Biological Process Annotations 2025	1.0	null
KISS1R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52446
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.36182
GTEX-OIZI-0126-SM-3NB13	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21925
GTEX-XQ3S-2726-SM-4BOP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39959
HUPT4	CCLE Cell Line Gene CNV Profiles	1.0	1.40967
GSE225901_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K01978082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00452
ZNF264	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08064
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.88669
inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.60024
CRCGN015_MCF10A_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8576
G-protein beta/gamma-subunit complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
Prostate adenocarcinoma_PRAD_TCGA-KK-A6DY-01A-12R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFO-21	GDSC Cell Line Gene Expression Profiles	-1.0	-2.74719
Neuroendocrine tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.583
Prostate adenocarcinoma_PRAD_TCGA-G9-7523-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NU-DUL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27398
POM121C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48315
brain endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.130842
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.8717
BRD-K66838288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.65854
ECHDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74593
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
Lung adenocarcinoma_LUAD_TCGA-44-6147-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BD-A3EP-11A-12R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endometrial gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.333763
Caudate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.196
SAC3D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55826
BRD-K35066174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46349
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.697
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4834
Lung squamous cell carcinoma_LUSC_TCGA-56-1622-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8423-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE240027,GSE240030_5_v_0_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BMI1-23680149-NPCS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43824
BRD-K59522787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23566
PMC9046280-41467_2022_29963_MOESM8_ESM.xlsx-Supplementary_Fig_4B-Genes_annotated_to_enhancers_bound_by_ASCL1_ChIP_and_lost_expression_in_42D_K_D_ASCL1_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47724892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.80349
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920553
nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045585
RELL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07799
GPCRs class A rhodopsin like	WikiPathways Pathways 2024	1.0	null
BRD-K77824583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04544
SKMEL30	DepMap CRISPR Gene Dependency	1.0	9.63641
cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8724
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.87088
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01586
CYFIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57434
BRD-K44427106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31617
Allergic contact dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.234
DOR 13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09747
H3K4me1_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K49733809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34715
PEA15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67979
H3K27me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EBNA1-20929547-CHIP-SEQ-RAJI-CELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CENPP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72022
GSE203308_1_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DNAL-CYC(CYS-TYR-DTRP-ORN-VAL)-NAL-NH2	DGIdb Drug Targets 2026	1.0	2.6466
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.419623
METTL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96429
MAFF	ENCODE Transcription Factor Targets	1.0	null
Allergic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
Breast sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
ANKRD40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05385
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.193
reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.368149
regulation of interleukin-6 production	GO Biological Process Annotations 2023	1.0	null
CRCGN014_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.47552
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03717
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7373
BRD-K48592348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01357
signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
BABAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96271
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.875
ZC3H13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78506
Antropyloric mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.78
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.920929
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.85897
TSEN34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56077
GSE67266_2_v_4_etoposide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TestisGermCell	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.45079
imatinib_homo sapiens_gpl96_gds3049	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.62735
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871825
CFLAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26602
periosteum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.150311
Neural lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.023
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.625711
Breast carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
Extrinsic component of cytoplasmic side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.243
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08305
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.39626
Lung adenocarcinoma_LUAD_TCGA-55-8512-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K27881453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22194
BRD-K57977694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68404
PC-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.42
l23	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.123
Lung adenocarcinoma_LUAD_TCGA-55-6986-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
[Leu<sup>8</sup>]-phyllolitorin	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
astroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.141019
ANKRD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61263
GSE122101,GSE122103_3_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K52881132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03882
MOLT16	CCLE Cell Line Gene Expression Profiles	1.0	1.67366
intrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.137618
capan-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.412011
FAM168B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7005
REST_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65214
RHODEI-LITORIN	DGIdb Drug Targets 2026	1.0	1.3233
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTF2H4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38118
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4768-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF217_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.678108
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936818
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4795-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76154866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09426
SLC35F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54648
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.24867
myeloma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.64529
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC265	CCLE Cell Line Gene Expression Profiles	1.0	2.12404
BRD-K65725294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17899
LARP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94568
ChIP_H3K27me3_18600261_mouseWholeBrain	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K63102090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75428
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61383
HLA-B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5514
Muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.648
NDUFAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52454
LMO2-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.920963
Perturb_4171_KO_Banf1_SRP302680	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	15.8579
PHYLLOLITORIN	DGIdb Drug Targets 2026	1.0	1.3233
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2014
PPM1J	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74689
ANPR-A receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.938
GTEX-S7SF-0626-SM-4AD4V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873628
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.61214
Cheek	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.215
FBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02571
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.76038
ELAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13599
g-protein coupled peptide receptor activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K16064200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45312
TRIM33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.35081
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853119
CRCGN008_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.1953
GTEX-PVOW-0011-R5A-SM-32PL7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27058
catalytic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.042495
BRD-K10157835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37581
regulation of osteoclast proliferation	GO Biological Process Annotations 2025	1.0	null
Uterine fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.52
PAQR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41274
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44255
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13445
PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.824442
PRC2_EZH2_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K99119142	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60984
PAFAH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82456
NFKBIE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50366
GSKIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44138
Lung adenocarcinoma_LUAD_TCGA-50-5933-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Breast osteosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.811
NEC8	GDSC Cell Line Gene Expression Profiles	1.0	1.54905
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3455-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
BRD-K86914375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02733
STAT5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94546
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.00392
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4166-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SG in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36303
SHISAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63327
BRD-K46458719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01292
BRD-K93941597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44287
Liver	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.303
extrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.16342
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.30582
BMI1	ChEA Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7659-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K65829768	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1409
autocrine	GeneRIF Biological Term Annotations	1.0	null
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39356
G alpha (q) signalling events	Reactome Pathways 2024	1.0	null
Red bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.579
FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9485
HuTu-80 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.011
SK-MES-1	GDSC Cell Line Gene Expression Profiles	1.0	2.70878
ARFGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9055
NUDT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70398
CRCGN014_HEPG2_3H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22571
BRD-K29298614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11251
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3176
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
SLC17A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62008
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22488
dNal-<i>cyc</i>(Cys-Tyr-dTrp-Orn-Val)-Nal-NH<sub>2</sub>	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A1OB-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Gene_Name_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.518859
SRI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41522
KYO1	CCLE Cell Line Gene CNV Profiles	1.0	1.39007
TASK1	DepMap CRISPR Gene Dependency	1.0	3.06285
U-87MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.989
Spinal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.318
neuroactive ligand receptor interaction	KEGG Pathways	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
BRD-K66016089	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.79361
CRCGN010_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26989
BRD-K04714488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02675
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4977-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.286
CRCGN016_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00629
Lymphoma_burkitts(Raji)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.55362
H3K27me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
regulation of interferon-alpha production	GO Biological Process Annotations 2025	1.0	null
GTEX-S4Q7-1226-SM-4AD5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50219
Signaling by GPCR	Reactome Pathways 2024	1.0	null
BRD-K36539857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90393
TYKNU	CCLE Cell Line Gene Expression Profiles	1.0	1.71768
ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.164359
TM9SF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84777
BRD-K64266251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13207
posteroventral (inferior) parietal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.983516
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.36302
CTDSPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93333
Trigeminal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.392
Enterovirus 71_4Hour_None_GSE15323	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.72289
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.575216
BRD-K84939696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.241
BRD-K10911459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02672
regulation of respiratory gaseous exchange	GO Biological Process Annotations 2025	1.0	null
SEMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05634
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35025
CXCR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75403
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20345
PAX3-FKHR-20663909-RHABDOMYOSARCOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-U4B1-1526-SM-4DXSL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51892
TP63	ChEA Transcription Factor Targets	1.0	null
RARB-27405468-CHIP-SEQ-BRAIN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HDAC2_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GMFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33041
SKBR3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56453
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60319
LS123	CCLE Cell Line Gene CNV Profiles	1.0	1.5665
TAL1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
neuropeptide receptor activity	GO Molecular Function Annotations 2015	1.0	null
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC39A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71676
UO31	BioGPS Cell Line Gene Expression Profiles	1.0	0.964637
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
COLO 792	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09747
ADCY7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32875
SF268	CCLE Cell Line Gene CNV Profiles	-1.0	-2.00061
REST_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3360606__F1	PFOCR Pathway Figure Associations 2023	1.0	null
outer SZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.920966
POR_KO_GDS1678_762_mouse_Jejunum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7828-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PD 176252	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
CRCGN010_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.75225
SLC37A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82539
inner SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18924
pituitary gland tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.163443
Small cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.123
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.6311
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.90121
coexpressed	GeneRIF Biological Term Annotations	1.0	null
BRD-K35404627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44972
GTEX-UJHI-1026-SM-4IHJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03765
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MAST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.174
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GF1B-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
colonic epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.477497
amygdalostriatal transition area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.988946
U20S	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.65082
GTEX-XAJ8-1326-SM-47JYT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41837
bombesin	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Signal Transduction	Reactome Pathways 2024	1.0	null
sulfadiazine-5523	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
orbital frontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.70048
pancreatic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.221061
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
REST_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TestisSeminiferousTubule	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.11091
regulation of osteoclast proliferation	GO Biological Process Annotations 2023	1.0	null
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.848
acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.369373
BRD-K75275329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27014
KM-H2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K34158806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32303
Oxygen	CTD Gene-Chemical Interactions	1.0	null
GSE195786_0_v_1_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.64849
SOX2	ChEA Transcription Factor Targets	1.0	null
NEXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47274
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEC108	CCLE Cell Line Gene Expression Profiles	1.0	2.79441
H3K27me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K53893978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14392
Lung Diseases	CTD Gene-Disease Associations	1.0	1.0353
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23838
BRD-K60587793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45134
BRD-K77591784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21599
BRD-K93846199	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16981
normal	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	133.211
UQCR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78729
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain stem	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.063
PAX3-FKHR-20663909-RHABDOMYOSARCOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.857739
EMC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01599
GALNT12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97123
A-VN-1203-2004(H5N1)_Day4-10^3pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.26639
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.641
Agranular insular cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.707
PD 165929	DGIdb Drug Targets 2026	1.0	2.6466
AR-22383394-PROSTATE-CANCER-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bronchial mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.340388
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.991019
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5330-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.62816
HIRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1416
BRD-K84278600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13149
LN18	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.859794
Hindbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.063
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09539
SKBR3	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.67622
ar4-2j cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.286026
BRD-K02837259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09495
CRCGN017_MCF10A.WT.HP_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51935
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A681-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43667
Neurological pain disorder_CNS - Spinal Cord (MMHCC)_GSE18803	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.581564
Prostate adenocarcinoma_PRAD_TCGA-HC-7817-01B-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
c6 glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.965496
BRD-K82700281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50155
NDUFA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29155
CSNK1G3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47177
BRD-K37625653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55171
GSE218580_1_v_0_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12845
HS746T	DepMap CRISPR Gene Dependency	1.0	2.51291
DLGAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20772
intrinsic component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
TMED4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55973
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
leflunomide-5884	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.329
macroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.12381
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1954
CRCGN014_HEPG2_3H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38572
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.53873
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.262
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10056
SETDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28233
BJHTERT	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47389
BRD-K34534297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37429
BRD-K32370845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19724
Mesothelioma_MESO_TCGA-SC-A6LN-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.09102
H3K27me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
OUMS27	CCLE Cell Line Gene Expression Profiles	-1.0	-2.29549
OCI-LY-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33399
H3K27me3_CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hydroxytoluic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0762
Trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.051
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31682
BRF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23497
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.71524
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854784
C9orf78	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0238
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.711183
cardiovascular diseases	GAD Gene-Disease Associations	1.0	null
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.71205
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
JHH7	CCLE Cell Line Gene Expression Profiles	1.0	1.77053
BRD-K56125296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33353
CXCR7_Deficiency_GDS3183_604_mouse_Neonatal semilunar valves	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M6-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91085913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99927
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70785
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066423
enalapril-7026	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
neuropeptide receptor activity	GO Molecular Function Annotations 2025	1.0	null
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K77407030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35367
BRD-K76748254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40001
small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.19889
MSH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.20958
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Antral mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.784
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40533
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78129
Stomach smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.983
BRD-K54081441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08096
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3753
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.478
CRCGN015_MCF10A.WT.HP_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.88349
BRD-K22679163	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92821
TMEM69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57438
TRPM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55749
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K31250130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21286
BMPR1A_knockout_222_GSE48092	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.05639
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.706754
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060823
NTMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.83647
CGRP receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.558
BRD-K58220566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70222
BRD-K69668461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85337
BRD-K39348592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16917
OCI-M2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19328
15q25 copy number variation	WikiPathways Pathways 2024	1.0	null
RETSAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0159
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04991
CCDC113	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50246
litorin	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K51535480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37938
BRD-K40841951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6374
act	GeneRIF Biological Term Annotations	1.0	null
CRCGN016_MCF10A.TP53.M_24H:M09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13024
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CDX2-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
U-373MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.075
BRD-K00620786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0323
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.52823
CRCGN017_MCF10A.WT.HP_24H:N21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4262
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K09250647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69727
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Pituitary gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.806
GPI-PLD_OE_GDS2049_176_human_Hepatoma HepG2 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KM-12C cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.744
TYW3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89997
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.52596
lateral portion of the shell	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32823
TALL-1	GDSC Cell Line Gene Expression Profiles	1.0	1.72026
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8089
LCOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57491
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
medial parabrachial nucleus,right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.971937
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4881
Lung squamous cell carcinoma_LUSC_TCGA-43-6773-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27579
Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9D1-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2912
HCC70	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.08819
SEPTIN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37088
RMGI	CCLE Cell Line Gene Expression Profiles	-1.0	-2.33408
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SU-DHL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3155
CDX2-21402776-INTESTINAL-VILLUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN012_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08715
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7061-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CHTF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76378
BRD-K87167435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70788
CRCGN014_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.12254
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.655
CHD1	ENCODE Transcription Factor Targets	1.0	null
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LZTS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45469
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33335
neuromedin	GeneRIF Biological Term Annotations	1.0	null
BRD-K12067186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6083
YWHAZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4804
BRD-K77869482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52966
BRD-K33770771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85299
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05446
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A902-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bombesin receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
BRD-K78310215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50897
Heart	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.31354
Gastrointestinal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.542
Brain Lower Grade Glioma_LGG_TCGA-DU-7290-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K68562280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46057
Hepatoma ascites cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.937
HCC202	CCLE Cell Line Gene CNV Profiles	-1.0	-2.81926
Nape	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.411
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1014
SERPINB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89918
Edinger-Westphal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01251
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5859
GSE111138,GSE111149_1_v_3_runx3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SARAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76214
BPTF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20115
PHF20L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40485
DCLRE1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81953
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
D-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-NAL-NH2	DGIdb Drug Targets 2026	1.0	0.8822
medial geniculate complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.53682
H3K27me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDC25A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3536
striatum_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.3324
UterusCorpus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.26307
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16245
NCIH146	CCLE Cell Line Gene CNV Profiles	1.0	1.57378
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5878-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K83845379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24284
G59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920553
principal sensory nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.862506
SDHAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79703
ACTR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75243
OCILY19	DepMap CRISPR Gene Dependency	1.0	4.52356
Iron Overload	DisGeNET Gene-Disease Associations	1.0	null
Excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.329
BRD-K72173400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69307
BRD-K87593103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33269
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44215
3T3-Swiss albino cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.349
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00214
BRD-K15940717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41203
BRD-K68485855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5476
CCDC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99633
CYREN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89022
UTP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31829
positive regulation of interferon-alpha production	GO Biological Process Annotations 2023	1.0	null
ENTPD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.10788
HCC-33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Hemochromatosis	DisGeNET Gene-Disease Associations	1.0	null
GSE216757_4_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2967-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal raphe nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.04423
GTEX-QVUS-0011-R1A-SM-3GAD2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11561
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.866811
dependent	GeneRIF Biological Term Annotations	1.0	null
homeostasis/metabolism phenotype	MPO Gene-Phenotype Associations	1.0	null
medulloblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.442194
KDM4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7052
dms53	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.668
mediodorsal nucleus of thalamus_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.844924
GTEX-QVJO-0011-R1A-SM-2S1QI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31561
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1591
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4534
496100462_PCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.32182
Prostate adenocarcinoma_PRAD_TCGA-EJ-5519-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.65092
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9387
G protein-coupled receptor, rhodopsin-like	InterPro Predicted Protein Domain Annotations	1.0	null
IZ in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.945665
PPP2R3C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88784
MERO83	DepMap CRISPR Gene Dependency	1.0	2.23424
PHPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79858
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.57276
zbtb7b_19734230_cd8_p14_memory_lof_mouse_gpl1261_gds3566	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.532302
BRD-K56041932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17428
Spinal trigeminal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.743
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26666
CRCGN015_MCF10A.TP53.M_24H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9671
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pc-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.435289
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.732
REST_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7467
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4870-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
PGM2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47571
DMS79	CCLE Cell Line Gene Expression Profiles	1.0	2.30409
spermatogonium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.176476
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00832
SK-MEL-28	GDSC Cell Line Gene Expression Profiles	-1.0	-1.45855
Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K45022385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.46562
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08967
CRCGN015_HEPG2_48H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.21178
BRD-K84663394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23482
SK23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920553
CRCGN010_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32411
Cerebellum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.063
BRD-K76640951	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18725
midbrain reticular formation	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.847758
FBXO22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6793
layer II of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.86151
ANGEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95186
NEUROMEDIN B	DGIdb Drug Targets 2026	1.0	1.3233
Area postrema	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.624
SKNMC	DepMap CRISPR Gene Dependency	1.0	3.44727
17724462-Table1	GeneSigDB Published Gene Signatures	1.0	null
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-fromNode_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of cytokine production	GO Biological Process Annotations 2023	1.0	null
GH3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.677
Peg cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.6
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.99407
HT29	BioGPS Cell Line Gene Expression Profiles	1.0	1.60439
PGC-1alpha_Deficiency_GDS4904_310_mouse_Aged gastrocnemius muscle - 10 weeks	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
NDUFA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5554
RARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0512
BRD-K67194214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51361
brain	GTEx Tissue Gene Expression Profiles	1.0	2.08859
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4622-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TX-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4527
CAPAN-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.727
Golgi cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.675
ATOH7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4779
BRD-K11844860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12043
CCDC87	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6947
RASA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80889
SDHAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76864
extrinsic component of cytoplasmic side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.241716
BRD-K70315531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60226
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K84935293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71096
Gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.306
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7439
CRCGN013_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0876
BRD-K74794014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32139
spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.181546
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23163
CRCGN014_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9473
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970469
MT-ATP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.31003
BRD-K27026825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44308
Brain Lower Grade Glioma_LGG_TCGA-DU-8166-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SERINC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92682
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5877-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.891344
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.91793
CRCGN009_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.27172
caudal putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.56944
PMC5855797__F2	PFOCR Pathway Figure Associations 2024	1.0	null
BBSome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.512
FSCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83757
Lung adenocarcinoma_LUAD_TCGA-55-8204-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07789
NCIH1666	DepMap CRISPR Gene Dependency	1.0	2.03904
HNRNPUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88645
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3385-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RIOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14777
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71345532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38727
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4784-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.9221
abnormal parental behavior	MPO Gene-Phenotype Associations	1.0	null
lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.367876
phospholipase C-activating G protein-coupled receptor signaling pathway	GO Biological Process Annotations 2023	1.0	null
Body size at age 10	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.1301
primary motor cortex (area M1, area 4)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.92036
thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.2723
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1504
positive regulation of osteoclast proliferation	GO Biological Process Annotations 2023	1.0	null
TGFBI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66591
KIF22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33122
POU3F2-20337985-501MEL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
15572690-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.6393
SIGIRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71598
ERBB2_druginhibition_7_GDS2139	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.54153
RGS14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97119
PXDNL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93826
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.932172
glioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.754124
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.630314
Intrinsic component of synaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.511
BRD-K29728947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.74933
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MTURN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40492
CRCGN015_MCF10A_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.8077
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
tongueepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.941894
NR6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.15296
BRD-A30547447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02782
TTC30A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27043
BRD-K86961579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17856
BRD-K62294866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81323
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08328
SLC16A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15572
CRCGN016_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.72728
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MI-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZS-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87875370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40044
BRD-K75610411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91884
LCAT	MSigDB Cancer Gene Co-expression Modules	1.0	null
pimasertib	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26446
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1193
cerebellar cortex_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.998986
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.95759
PTPRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54573
ABCC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74625
FBXW8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76478
ZNF706	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16376
Visceral mass	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
REST_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Median eminence	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.756
FTH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01361
PRDX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35655
hippocampus (hippocampal formation)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.02627
CHAC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.75735
basal nucleus of meynert, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.96725
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7647
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SJ-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5258-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE155830_3_v_0_fkbp5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-99-8028-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K56161792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58165
CRCGN017_MCF10A.WT.HP_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69635
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.758
BRD-K14394756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09843
Viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.329
COLO678	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7396
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.86577
SYNGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42307
GTEX-NL3H-0011-R5a-SM-2I3GB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965189
allantoic fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.609332
torasemide-5476	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
uterine fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.451042
SLC31A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96938
striatum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21533
TAL1-21186366-BM-HSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10822
bed nucleus of stria terminalis	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.875266
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.99249
[125I]BH-NMB (HUMAN, MOUSE, RAT)	DGIdb Drug Targets 2026	1.0	2.6466
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8C_Het1A-HNF4A_2d_5x_closed-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
ALG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64317
Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.303
PNPLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14675
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3011
SUM52PE	DepMap CRISPR Gene Dependency	1.0	2.22077
TXNDC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48113
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A1H5-01A-31R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM106B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32298
L363	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40829
CRCGN016_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.55075
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.643
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.1711
CRCGN017_MCF10A.WT.HP_24H:A21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19895
PMC6299095-41389_2018_108_MOESM4_ESM.xlsx-T47D-TRPS1_peak-gene_symbol_TRPS1	Rummagene Transcription Factor Associations 2026	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.883509
Splenomegaly	CTD Gene-Disease Associations	1.0	1.05237
bronchus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.333763
PTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87933
Female urethra	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.08
Brain Lower Grade Glioma_LGG_TCGA-CS-6668-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neuroectodermal tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.353395
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GT-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
extrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.134495
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL3H-0011-R2a-SM-2I3GG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864223
ZNF674	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41825
HS852T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53455
SK-MEL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.846182
Lung adenocarcinoma_LUAD_TCGA-86-8076-01A-31R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95428783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22892
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R2A-SM-32QOW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10588
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920553
REST_Panc1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
median nucleus of thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.235167
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_DEPLETION_GDS3294_97_mouse_germinal vesicle (GV) oocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.9978
bronchial epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.179711
BRD-K17020860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27649
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4735-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.19964
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.2779
Cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C7-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF534	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66594
LY6E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92796
KNS81	DepMap CRISPR Gene Dependency	1.0	3.46493
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33399
NPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31157
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.3595
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K43284834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60497
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957899
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.6312
membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K51185182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23755
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Nearest_Ensembl_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LD-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49207204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28473
BRD-K90527476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00361
POU2F2	JASPAR Predicted Transcription Factor Targets	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.70045
Kidney Chromophobe_KICH_TCGA-KN-8428-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.392
uterine luminal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.726507
hbe cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.514136
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PROP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44557
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07372
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR3C1-21868756-MCF10A-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
TET2_KO_GDS4287_429_mouse_LSK - bone marrow progenitor population	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K92565319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4135
BRD-K63436783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70755
HS737T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.4628
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	9.793
miapaca-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214017
BRD-K35462157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31257
KNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.822
SKNAS	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6525
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5949
temporal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.12883
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09606
RPE1SS51	DepMap CRISPR Gene Dependency	1.0	2.91778
BRD-K76202128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14986
PANK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83858
POU5F1_01_05	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.24998
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.86172
BACH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79532
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
E2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3334
CRCGN013_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.94949
BRD-K55584718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27345
ABHD14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49069
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.72331
CFTR_Deficiency_GDS1843_192_mouse_Lungs - Animals examined at 6 weeks of age	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-P4PQ-1526-SM-3NMCK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956027
KARPAS422	CCLE Cell Line Gene Expression Profiles	1.0	1.36031
BRD-K19378563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42537
medial nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.858911
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864332
phyllolitorin	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K56563145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29854
ARPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3377
KMS28BM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41003
BRD-K96023136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15285
BRD-K45348630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30921
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.598469
PRRC2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60985
vagina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.193244
BRD-K23461342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0806
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K21897482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33109
ZBED1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.754
TCF7L2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1931
eGFP-FOS_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal maternal behavior	MPO Gene-Phenotype Associations	1.0	null
BRD-K65729622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.65267
RFX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62686
GADD45G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57051
HCC1395	Achilles Cell Line Gene Essentiality Profiles	1.0	1.2687
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.47176
SUZ12-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K26024910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79123
macelignan	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22653
BRD-K52372795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41359
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.07671
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9408
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.95718
G protein-coupled peptide receptor activity	GO Molecular Function Annotations 2025	1.0	null
CRCGN008_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08745
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95555
SHISA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4056
gastrointestinal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.612152
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVCA433	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PFSK1	DepMap CRISPR Gene Dependency	1.0	4.38428
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86951121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21708
H3K27me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
KYSE510	DepMap CRISPR Gene Dependency	1.0	2.05907
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.14581
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09494
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2555
M059K	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.35773
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10204
Pars tuberalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.773
lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.847898
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18977
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-e-Classification_of_camel_SON_basal_genes_-_G_protein_coupled_receptors_SON	Rummagene Transcription Factor Associations 2026	1.0	null
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPTC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01161
signal transduction	GO Biological Process Annotations 2015	1.0	null
digits	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.54164
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
TSPAN33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03293
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8243
CRCGN017_MCF10A.TP53.M_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.6325
[D-PHE6,&BETA;-ALA11,PHE13,NLE14]BOMBESIN-(6-14)	DGIdb Drug Targets 2026	1.0	0.8822
CRCGN013_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15585
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.632335
KLF2_02_29	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63743
XBP1_OE_GDS5065_273_mouse_F424a adipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Peptide ligand-binding receptors	Reactome Pathways 2014	1.0	null
Signaling by GPCR	Reactome Pathways 2014	1.0	null
SYNRG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00403
proliferating	GeneRIF Biological Term Annotations	1.0	null
SCC15	CCLE Cell Line Gene CNV Profiles	1.0	1.68519
Kidney renal papillary cell carcinoma_KIRP_TCGA-EV-5901-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TKT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54736
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2556
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.8834
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.33269
ZDHHC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47365
TAF1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.354
NCI-H82 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829563
CRCGN015_MCF10A_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.82355
Prostate adenocarcinoma_PRAD_TCGA-J4-A83J-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09591
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.8026
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.928731
MRPS30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50904
BRD-K37000177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92489
GPR180	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44746
BRD-K44421266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91673
PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-302-POU5F1P4_POU5F1B	Rummagene Transcription Factor Associations 2026	1.0	null
rostral presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.1359
CRCGN013_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28824
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
BRD-K91854399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15018
LDB1-21186366-BM-HSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.533
Middle temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.578
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02625
RAB17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93004
mediodorsal nucleus of thalamus_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.974704
P300-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3859
amygdaloid complex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.31184
CA1 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.866247
H3K9me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PHGDH_KO_GDS2874_125_mouse_embryonic head tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.472412
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
germ cell and embryonal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.27153
KMS26	CCLE Cell Line Gene Expression Profiles	1.0	1.54688
HCST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16578
GIMEN	DepMap CRISPR Gene Dependency	1.0	2.21318
Retinoschisis_Retina_GSE5581	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.643231
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.00545
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09631
Head	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
PLEKHA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55012
PUS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40058
GTEX-XLM4-1526-SM-4AT6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53119
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6088-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
non-small cell lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.51919
CCDC184	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38374
CREB3L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86677
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.629
MTHFSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93327
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.881594
[LEU8]-PHYLLOLITORIN	DGIdb Drug Targets 2026	1.0	1.3233
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.82616
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15791
SIRT6	ENCODE Transcription Factor Targets	1.0	null
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
amygdaloid complex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02362
inner chondrogenic layer of perichondrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.429165
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.67036
GTEX-RNOR-0011-R9A-SM-2TF52	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3553
SNU626	DepMap CRISPR Gene Dependency	1.0	2.47527
BRD-K27083306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49123
496100384_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.46721
TMEM151B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62882
Olfactory cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.701
[<sup>125</sup>I]BH-NMB	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
PPM1M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41457
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.683919
BRD-K93040255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10752
A-VN-1203-2004(H5N1)_Day7-10^3pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.09057
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971224
Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0536
NMB	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.8408
BRD-K53343197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33873
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
H3K9me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7001
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.42699
TMEM222	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56161
TWSG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48715
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24833
Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EM2	CCLE Cell Line Gene CNV Profiles	1.0	2.1359
BRD-K46623934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18241
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.419644
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.5447
BRD-K01266518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20601
MAGED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22136
Noc complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.691
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.838014
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40166
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97576000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79247
SIX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4744
phenacemide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16467
BRD-A25184723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40582
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-Downstream_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.271
GTEX-Q2AG-0011-R2A-SM-2HMIT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16983
ELK1::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7201
ZDHHC24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43499
NCI-H1793	GDSC Cell Line Gene Expression Profiles	1.0	1.41718
BRD-K48389518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18563
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34846
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03804
GINS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31882
HS939T	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45925
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.07534
rostral group of intralaminar nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.16761
cardiovascular	GAD High Level Gene-Disease Associations	1.0	0.293278
TIGD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25378
Tracheal smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.808
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.2215
MTRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48474
NCI-H2347	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09747
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-7848-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.106
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GPCR, rhodopsin-like, 7TM	InterPro Predicted Protein Domain Annotations	1.0	null
SNU182	CCLE Cell Line Gene CNV Profiles	1.0	1.34893
BRD-K64075179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28221
OLIG2	ChEA Transcription Factor Targets	1.0	null
outer SZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.936108
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.28795
BRD-K41311678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48574
GSE235596_0_v_1_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DNAJC30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84704
cerebellum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.872128
NCIH2171	CCLE Cell Line Gene Expression Profiles	1.0	1.94561
H3K27me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ESRRG_Deficiency_GDS2811_637_mouse_Fetal heart - Heterozygous null mutant	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
LU165	DepMap CRISPR Gene Dependency	1.0	2.79941
BRD-K98510376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97165
DUT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52515
orbital frontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.831711
BRD-K71604365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1749
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1384
SEPTIN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90206
GM2493	BioGPS Cell Line Gene Expression Profiles	1.0	1.32982
BRD-K64066545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61425
primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.48561
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67042
NADK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41437
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.7786
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.72039
PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
A-VN-1203-2004(H5N1)_Day7-10^2pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.80231
BRD-K48129913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70457
RANATENSIN	DGIdb Drug Targets 2026	1.0	1.3233
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.474
klf4_17017123_rko_gof_human_gpl96_gds1942	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.236399
BRD-K13436682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24624
Zona glomerulosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.759
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
TOP3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6302
TYKNU	CCLE Cell Line Gene CNV Profiles	-1.0	-1.96798
Spinothalamic tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.38962
ME-180	GDSC Cell Line Gene Expression Profiles	1.0	1.60423
VMRCLCD	DepMap CRISPR Gene Dependency	1.0	5.52026
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DX-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74311661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29609
CAVIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15127
ZFX_KO_GDS2718_150_mouse_embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K09376136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82516
CHOP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.507
Kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.329
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.57301
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23214
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16366
CRCGN012_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28713
LRRC8D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43495
IPO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78759
GTEX-XMD1-0011-R5A-SM-4AT47	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24148
BRD-K16717067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14052
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4222
CRCGN011_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5635
FOSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4719
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09227140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70723
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.940032
RCC4	CCLE Cell Line Gene Expression Profiles	-1.0	-2.50769
SUZ12-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MANBA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98959
CORL24	CCLE Cell Line Gene Expression Profiles	1.0	2.78943
capan-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.518072
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.862763
Membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.0008
Psoriasis vulgaris_Skin tissue_GSE14905	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.74049
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5153-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKNO1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.88452
ZSCAN26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87913
POLR1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81553
ZNF501	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50579
PPARD-21283829-MYOFIBROBLAST-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PMC6162445__F3	PFOCR Pathway Figure Associations 2023	1.0	null
PMC10709143-41556_2023_1271_MOESM9_ESM.xls-Up_in_PAX7--Target_name_PAX7	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.06601
REST_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K47228832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6721
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K17065706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81898
PSMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48219
H3K27me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE191138_3_v_4_fmo3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
WM88	DepMap CRISPR Gene Dependency	1.0	2.42761
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37878
PPFIA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42905
SLC25A36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25371
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.881337
Neuroactive ligand-receptor interaction	KEGG Pathways 2026	1.0	null
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3129
H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
isometheptene-6524	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-EU-5904-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RU1J-0526-SM-46MUT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27461
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.28324
ZNF701	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63261
ZNF705A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56583
medulloblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.19582
CALD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51855
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_1_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02784
NEUROMEDIN B (1-30) (HUMAN)	DGIdb Drug Targets 2026	1.0	1.3233
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.301
PD 168368	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
HCC2998	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.859794
Midbrain central gray	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.728
CRCGN017_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96854
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.828
stomach	GTEx Tissue Gene Expression Profiles	1.0	1.02724
REST_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amygdaloid complex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13262
CEP164	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.03412
H3K27me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1348
EXT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51586
GSE188382_2_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00411
PDCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27392
C-fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.64
inferior olive, dorsal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.50372
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K59957369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84986
REST_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LA-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.944218
G alpha (q) signalling events	Reactome Pathways 2014	1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04848
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3450-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFP57-27257070-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Epididymis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCI-N417 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.878
POU3F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63321
RCOR1	ChEA Transcription Factor Targets	1.0	null
PMC5855797__F2	PFOCR Pathway Figure Associations 2023	1.0	null
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.965518
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.626677
HCFC1	ENCODE Transcription Factor Targets	1.0	null
NCIH1385	CCLE Cell Line Gene CNV Profiles	-1.0	-2.23247
SW1271	CCLE Cell Line Gene Expression Profiles	-1.0	-1.64531
UBLCP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53535
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-S95S-1126-SM-4B64E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47016
KLF1	ChEA Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.49499
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TMBIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95519
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.11531
PMC11193738-41467_2024_48647_MOESM8_ESM.xlsx-Data_S5-Data_S5_HNF4A-bound_gene_targets_identified_from_ChIP-Seq_in_hepatic_cells_D8_Hep_and_HepG2_cells_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
NSA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25395
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.992849
ADCY5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.0213
lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.770435
BRD-K18488784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50541
GTEX-XLM4-0011-R8A-SM-4AT44	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864556
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K90155857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05416
Class A/1 (Rhodopsin-like receptors)	Reactome Pathways 2024	1.0	null
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.921577
BRD-K44193634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17808
DYNC1LI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17983
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.66972
BRD-K98271666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9449
SIN3A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4931
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4947
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.792
Perturb_14494_KO_Igsf11_SRP320670	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.72319
CRCGN016_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.09045
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q5-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0433
BRD-K65184008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88405
g-protein coupled receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3316-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FGD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80797
H3K27me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HDDC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82003
primary visual cortex (striate cortex, area V1/17)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.839536
H3K27me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10916124-12864_2024_10174_MOESM1_ESM.xlsx-Supplementary_Table_6-The_downstream_genes_targeted_by_FLI1_The_ligand_vs_receptor_pairs_genes_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65736
GPCR ligand binding	Reactome Pathways 2024	1.0	null
Dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.074
BRD-K26127722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00795
MN-60	COSMIC Cell Line Gene Mutation Profiles	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214765
lung cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.677803
Carcinoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.014
NOMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10499
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6233
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MSX2_MSX2	Rummagene Transcription Factor Associations 2026	1.0	null
LGALSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57105
neurotransmitter receptor activity	GO Molecular Function Annotations 2015	1.0	null
PMC8423434-mmc7.xlsx-SOX2_HENSM-Genes_n_2733_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K27597444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31005
Human - Motor Cortex - Cluster - LAMP5+ NMBR+ Layer 1 GABAergic neuron	HuBMAP Azimuth Cell Type Annotations	1.0	null
abnormal social/conspecific interaction	MPO Gene-Phenotype Associations	1.0	null
KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ALG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97493
ranatensin	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.358174
SARM_KO_GDS4842_411_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19538
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.6608
PAAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88394
BRD-K56775726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03504
SK-N-FI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
exocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.181724
ENHO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81647
BRD-K31621670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26513
BRD-K76263570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10874
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH1395	CCLE Cell Line Gene CNV Profiles	-1.0	-2.5094
BRD-K78818514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22365
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068283
CRX-20693478-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.04785
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.631527
Heart Diseases	CTD Gene-Disease Associations	1.0	1.01249
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7869
BRD-K27236794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34007
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.8602
Adrenocortical carcinoma_ACC_TCGA-OR-A5JD-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0064
FGF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17104
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.7607
PMC7181746-41467_2020_15886_MOESM8_ESM.xlsx-Patient_8_CCF-Affected_Genes_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A4IH-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K29028138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0298
BRD-K76461283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24217
FAM72A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21942
GTEX-S4P3-0726-SM-4AD57	GTEx Tissue Sample Gene Expression Profiles	1.0	0.98164
CRCGN015_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.74545
MDAMB435S	DepMap CRISPR Gene Dependency	1.0	2.03412
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.7454
brain cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.705173
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.656648
brain cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.257237
epididymis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD4-25478319-HGPS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14076
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0463
POMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39897
CRCGN008_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7769
SARS-CoV MA15_Day2-PFU-10^5_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.68198
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5286
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1406
ATF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4287
inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06796
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.5309
VDAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98893
SUZ12	ChEA Transcription Factor Targets	1.0	null
Schizophrenia	DisGeNET Gene-Disease Associations	1.0	null
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54079
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059999
Forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.45482
HDAC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74847
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Neuron_Brain_Human	CellMarker Gene-Cell Type Associations	1.0	null
cytoplasmic side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.241356
496100414_TCx_probable Alzheimer's disease_no TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31842
CLDND2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27787
BRD-K51520673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26293
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06388
SIRT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.73248
Perturb_8613_KO_Ctcf_SRP078142	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	14.506
BRD-K03093950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16303
positive regulation of multicellular organismal process	GO Biological Process Annotations 2025	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61I-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2797
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.671
BRD-K65438558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02713
PFKFB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43935
GTEX-WFG8-1926-SM-4LVM1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38396
nih-3t3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.05501
TEAD4_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55386
CRCGN016_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4228
Cardiovascular Diseases	HuGE Navigator Gene-Phenotype Associations	1.0	null
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2285
BRD-K12097074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00011
TSSK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.03578
PMC7450273-mmc2.xlsx-ST18-Unnamed_3_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
DNAJC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51486
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SI-01A-31R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Non-odorant GPCRs(Mus musculus)	WikiPathways Pathways 2014	1.0	null
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17072
EMX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.87629
BRD-K52148119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0676
PRR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44314
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4209
PD 176252	DGIdb Drug Targets 2026	1.0	1.3233
Idiopathic fibrosing alveolitis_Lung Tissue_GSE21369	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.50083
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4626-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.53
FAHD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.029
HMV-II	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51577
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN014_HEPG2_3H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.86146
abnormal maternal nurturing	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me1_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TRIM32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23718
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82601
IL21_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
BRD-K83670600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02066
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Interneuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.554
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IRF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82794
medial geniculate body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.298165
BMI1-23680149-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K59960811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.84343
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.59845
HM13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86811
NCIH526	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68092
BRD-K47984776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00512
KYM1	CCLE Cell Line Gene Expression Profiles	1.0	1.58391
MC116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.371619
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-ENSEMBL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
MEIS1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
acetylcholine-gated channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.746
PXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9349
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00214
GTEX-UPK5-1326-SM-4IHLE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848111
HNF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3874
MED25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28584
Gastric leiomyoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.092043
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.97595
PMC6501765__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Pparg::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.3075
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15824
SNU324	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40135
SS18L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26958
BRD-K49673270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17052
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.064
HUT78	CCLE Cell Line Gene CNV Profiles	1.0	1.47701
GTEX-PW2O-1426-SM-48TCD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32105
ZNF385A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74204
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM201	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69436
CRCGN015_HEPG2_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.02245
MCF12A	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.90337
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Liver hepatocellular carcinoma_LIHC_TCGA-HP-A5MZ-01A-21R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATP1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25545
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
bronchial epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.512171
Corpus albicans	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.664
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67055
BRD-K35808731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38972
BRD-K00611112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64355
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
YBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23027
BRD-K52428486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58709
GATA3_01_163	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63347
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.588
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4885-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053784
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K70856965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77976
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.21561
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.62421
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HTC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.939
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.81052
MROH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85387
glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.168507
Perturb_1064_KO_Esr1_SRP168132	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.92768
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86782
GLUD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10469
BRD-K48338059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72274
BRD-K73039647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88152
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54K-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MCM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42097
Brain Lower Grade Glioma_LGG_TCGA-FG-6688-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS 940.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48659
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2331
SPI1	ENCODE Transcription Factor Targets	1.0	null
Cytoplasmic side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.238
BRD-K38955287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1427
NCIH1650	Achilles Cell Line Gene Essentiality Profiles	1.0	1.33913
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77945
NIH-3T3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.531
BRD-K32727528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25446
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K77578964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39038
H3K27me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
neuropeptide receptor activity	GO Molecular Function Annotations 2023	1.0	null
chr6_142118677_C_A_b38	GTEx eQTL 2025	1.0	1.27908
BRD-K03312699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43853
Perturb_16609_KO_Larp7_SRP189392	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.30817
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09047
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A24D-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ2-0926-SM-4DXU5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04509
GCT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35157
pancreatic adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.178435
H3K27me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.833845
Breast Neoplasms	CTD Gene-Disease Associations	1.0	2.88009
bephenium hydroxynaphthoate-5263	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE149442_1_v_0_gdpd3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JF-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cervicovaginal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.311507
primary visual cortex (striate cortex, area V1/17)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-3.26153
Vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.648
PMC6471792__F3	PFOCR Pathway Figure Associations 2024	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN017_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0086
MEIOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54865
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K09511124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03011
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.95784
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074907
BRD-K70945620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12336
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.813979
CRCGN016_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.48967
MANEAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89617
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.83019
CRCGN017_MCF10A.WT.HP_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.20627
LAMA84	CCLE Cell Line Gene CNV Profiles	1.0	1.394
perichondrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24804
GTEX-RVPV-0011-R5A-SM-2TF69	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1028
BRD-K50240676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81969
GSE178907_4_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CAMTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47582
mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068666
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.06064
RAVER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37488
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.65736
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4622
Disease	Reactome Pathways 2014	1.0	null
cerebellar cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24108
FOXC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70758
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.3241
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4760-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
INKA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84452
GTEX-WZTO-0011-R7B-SM-4E3IS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07688
H3K27me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE243199_1_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
KMS-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26967
KCNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0265
WDFY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37517
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K71204648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7694
BRD-K04087396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03761
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8569
CRCGN014_HEPG2_3H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.9519
ERAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14922
GLUL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22583
Junctional membrane complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.874
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.8247
LMX1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52934
abnormal maternal nurturing	MPO Gene-Phenotype Associations	1.0	null
CELSR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90182
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
dentate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08877
SOX9-26525672-CHIP-SEQ-LIMBBUDS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K50177531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01568
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.8464
EMC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90726
BRD-K60017729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99688
PRELID3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11171
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A5A3-11A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrin-CREB signalling pathway via PKC and MAPK	Reactome Pathways 2014	1.0	null
brain cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.134976
SG in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22131
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A5UE-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8C_Het1A-HNF4A_2d_5x_closed-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
FUNDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05659
CERS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18953
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K23617623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28364
astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.142826
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.683093
Alanine aminotransferase levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.809691
CRCGN015_HEPG2_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.31824
monocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.117877
hypoxia	GeneRIF Biological Term Annotations	1.0	null
inner CP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27598
SYNGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28487
SOX2-22085726-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.59195
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.949132
Posterior amygdala	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.528
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43049
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12658
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYBS-0926-SM-3NM94	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3075
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067599
BRD-K98535230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04701
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5633-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COMMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05983
primary somatosensory cortex (area S1, areas 3,1,2)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.45304
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
NCI-H1155	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SP in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.954328
Metabolic disorders of biological oxidation enzymes	Reactome Pathways 2014	1.0	null
bronchoalveolar system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23459
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HNRNPU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07198
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.447
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.982581
SUPT1	DepMap CRISPR Gene Dependency	1.0	3.03171
epithelial	GeneRIF Biological Term Annotations	1.0	null
DBTRG05MG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57921
BRD-K07276022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02052
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37812
KYAT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15581
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.950393
BRD-K03116744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42622
BRD-K44139682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55795
Peptide GPCRs(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
JVE015	DepMap CRISPR Gene Dependency	1.0	7.44002
GSE108675_3_v_0_slc1a4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal homeostasis	MPO Gene-Phenotype Associations	1.0	null
Respiratory bronchiole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.832171
GTPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.224
MSLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63673
LARP4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69795
GTEX-REY6-0126-SM-48FDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87058
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855477
LIVF001-008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93565
BRD-K18149487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77057
BRD-K94088431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74269
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90208
medial geniculate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.399492
REST_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ICC12	DepMap CRISPR Gene Dependency	1.0	3.43303
Lung squamous cell carcinoma_LUSC_TCGA-56-8309-11A-01R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
kuwanon H	CTD Gene-Chemical Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5939-01A-11R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COX11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29694
CL-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13788
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pituitary gland tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.777
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POR_DELETION_GDS1093_240_mouse_Liver from male 3 month old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.307528
Nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
NCI-H1436	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.71625
THAP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73337
non-small cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.363393
MAFK_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP5F1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88918
uterine endometrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091374
ChIP_SUZ12_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.373868
MOLT-4	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6581
Bombesin receptor	InterPro Predicted Protein Domain Annotations	1.0	null
CRX_NRL_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.70366
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PCDH18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0458
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AP-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STK11IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70721
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
LAMTOR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51372
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.2151
inner CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44164
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
Medulloblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.035
ELMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54263
CRCGN010_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68865
EID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95716
CNOT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70434
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6938-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72345
TGF-beta_OE_GDS2974_137_mouse_corneas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
SH3PXD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2961
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.988
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909054
BRD-K23342427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72555
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
supramammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.987648
BRD-K14533399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0209
TMEM216	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66677
GK_KO_GDS2610_162_mouse_Brown adipose tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K27me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FAM200C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0341
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3556
RSRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24679
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K95192796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49826
REST_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF593	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84645
fetal membrane	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091813
CTNNB1_OE_GDS4449_352_mouse_Embryonic kidney from E12.5 embryos (-catGOF-UB mutant)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.239913
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
GPCR downstream signaling	Reactome Pathways 2014	1.0	null
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-PeakCall_EPC1-PHF1_FLAG_K562-SYMBOL_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH2122	Achilles Cell Line Gene Essentiality Profiles	1.0	1.25862
BRD-K17060750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.02323
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.74773
Rhodei-litorin	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBE2Q1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46574
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_2day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.31302
PHLDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23461
factor1alpha	GeneRIF Biological Term Annotations	1.0	null
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.2316
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.09491
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMR6-0011-R5A-SM-32PKT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95773
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87943
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PD 168368	DGIdb Drug Targets 2026	1.0	1.3233
MIS18BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08338
SEC23IP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47641
Hereditary Hemochromatosis	DisGeNET Gene-Disease Associations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4533-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.359292
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.057318
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.06619
BRD-K42139332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42529
STX1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11111
bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.122922
SH4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71739
BRD-K84788922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57786
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7
BRD-K69536411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62597
CRCGN014_HEPG2_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.94385
prostate gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.368624
HLA-C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9883
IRS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42324
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15375
Atopic dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RI1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.70517
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.941038
16424041-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
OCT4-21477851-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25147
FRK	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE136622_6_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152050,GSE152052_1_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1875
CAPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.04598
NOMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35034
BRD-K60661821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25104
BRD-K05796207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15223
KCTD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40332
TEAD4	ENCODE Transcription Factor Targets	1.0	null
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45781
PCDHB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99657
EIF4EBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94687
BACH1	ENCODE Transcription Factor Targets	1.0	null
LARP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74932
A172	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.14224
KLF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94499
SUZ12-16625203-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
MICAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03298
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3376-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRMT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.43152
molecular_function	GO Molecular Function Annotations 2015	1.0	null
Agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
PRAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4892
CAL-33	GDSC Cell Line Gene Expression Profiles	1.0	1.45181
BRD-K69515345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92894
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.41
Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13968264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23124
C1GALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36855
plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
pancreatic duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.191302
REST_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Trigeminal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.307
mecamylamine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13952
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3467-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U8T8-1126-SM-4DXUE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48433
BRD-K71214345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01545
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.14628
AGO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30589
KLHL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94119
negative regulation of interleukin-6 production	GO Biological Process Annotations 2025	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.7321
BRD-K90660470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18054
BRD-K42091424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73311
H3K27me3_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12619
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.6685
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75822
Inflammation	CTD Gene-Disease Associations	1.0	1.54281
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4799-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
Sarcoma_SARC_TCGA-DX-A3LS-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K61565464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35137
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.8237
secondary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.62991
BRD-K33061098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37078
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.871653
CRCGN015_HEPG2_48H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.20162
peptide receptor activity	GO Molecular Function Annotations 2015	1.0	null
SU-DHL-6	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sarcoma_SARC_TCGA-X6-A8C7-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06448
BRD-K99953989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01504
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CACNA2D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37573
PURA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2762
MYL6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53356
Prostate adenocarcinoma_PRAD_TCGA-EJ-7792-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STEAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79738
TCEAL8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34982
BRD-K91511557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82542
HDAC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72602
496100589_PCx_dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10651
Exocrine acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.969
TYK-NU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.03265
Small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.615
BRD-A14842104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08705
GTEX-PWO3-0011-R6A-SM-2I5F3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5304
BRD-K65959331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98131
BRD-K28165728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.55118
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.13432
GTEX-NPJ8-0011-R5a-SM-2HMJY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22779
NBR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36612
BRD-K58932103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2061
ZNF423	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02657
TMEM249	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.77917
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.291722
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2914-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H2795	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27398
Sarcoma_SARC_TCGA-FX-A2QS-11A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-0011-R7A-SM-32PKF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891467
CERS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2097
RGL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10075
MAPK15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65099
CDCA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12766
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965708
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8208
cerebellum_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.978714
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.329
BRD-K76492619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.56731
sneeze reflex	GO Biological Process Annotations 2025	1.0	null
BRD-K77987907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32188
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
D-NAL,CYS,TYR,D-TRP,ORN,VAL,CYS,NAL-NH2	DGIdb Drug Targets 2026	1.0	1.3233
BRD-K23232542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08263
HUPT4	DepMap CRISPR Gene Dependency	1.0	3.7975
BRD-K11942486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02741
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.925598
MTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.23855
inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.963565
ATF2	ENCODE Transcription Factor Targets	1.0	null
BRD-K84090286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33752
SEMA4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19572
GATA3-21878914-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5714
MCAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30849
SPIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77183
midbrain raphe nuclei	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.08596
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
FH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09584
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.55405
LCN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99338
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.540981
CAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61859
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
TMEM254	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91999
cerebellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.369373
GET4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27982
UACC893	CCLE Cell Line Gene CNV Profiles	1.0	1.80164
VMRC-RCZ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1673
ZBTB8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2294
Class A/1 (Rhodopsin-like receptors)	Reactome Pathways 2014	1.0	null
NCI-H1568	COSMIC Cell Line Gene Mutation Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
APLP2_KO_GDS4414_371_mouse_prefrontal cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K09395335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45482
BRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39083
BRD-K22449045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78721
BRD-K25822126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.497
brain cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049507
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065744
CEP55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7244
membrane	GO Cellular Component Annotations 2015	1.0	null
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.644858
EXOSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90244
SAP30	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-11A-13R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2273
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26104
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MON1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0845
Memory Disorders	CTD Gene-Disease Associations	1.0	1.05312
SAMD4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59913
CD200	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94349
METTL24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52162
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
MYO9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51808
REST_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SBC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K62072978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70478
bone marrow cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.563238
BRD-K74096348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.296
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.937052
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.3829
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4939
GATA3	ENCODE Transcription Factor Targets	1.0	null
gastrinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.503824
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
phospholipase c-activating g-protein coupled receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
BRD-K47445962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76159
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
PFEIFFER	CCLE Cell Line Gene Expression Profiles	1.0	1.39022
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
RBM33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13531
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.174
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
OLIG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5369
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QA-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNAI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.1185
GSE180200,GSE180201_2_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97359891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01793
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.91215
H3K27me3_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K52500055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11038
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.7619
Corticotroph adenoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.12
prostate carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.116506
ZNF395	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72649
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3801
ATAD3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34915
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.549
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PCDHB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49937
DGCR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56365
GTEX-TKQ1-0526-SM-4DXTG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.899608
Lysosomal multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.874
ZNF384	ENCODE Transcription Factor Targets	1.0	null
BRD-K93457574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84525
SFT2D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43114
BRD-K73463737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60531
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
Side of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.148
H3K27me3_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05753
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.889057
SLC24A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41991
PITPNM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10412
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A61046366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03453
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.39441
cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bronchial epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.469211
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8Q9-01A-12R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K45050268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77358
mediodorsal nucleus of thalamus_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02194
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42374
negative regulation of interleukin-6 production	GO Biological Process Annotations 2023	1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A894-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
respiratory epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.295655
Brain Lower Grade Glioma_LGG_TCGA-S9-A89V-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN012_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.99815
u-373mg cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.296013
Lung adenocarcinoma_LUAD_TCGA-55-6985-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K64567083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8812
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D5-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K41574232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4076
HOXA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37046
SPAG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43158
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996731
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.65137
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.898399
striatum_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.26093
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
OLIG2-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
abnormal behavior	MPO Gene-Phenotype Associations	1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069153
BRD-K84266230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17397
Fibrosis	CTD Gene-Disease Associations	1.0	1.31387
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941317
SMARCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29241
Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
astrocytoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.718703
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30114
Lung squamous cell carcinoma_LUSC_TCGA-60-2695-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10115638-41591_2023_2255_MOESM4_ESM.xlsx-LGG_MYB_L1_deletions-Extended_Data_Table_2_Significant_regions_of_DNA_copy-number_alterations_by_DNA_methylation_class_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
SKCO1	Achilles Cell Line Gene Essentiality Profiles	1.0	3.19224
gamma-delta T cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.612
TRPM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72884
regulation of interleukin-6 production	GO Biological Process Annotations 2025	1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24416
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
Communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
BRD-K42679620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88848
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8272
Neuromedin B receptor	InterPro Predicted Protein Domain Annotations	1.0	null
GSE210101,GSE210114_6_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.9473
deep layers of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38212
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.291
Zona incerta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.13
SEPTIN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55921
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.75702
Systolic blood pressure response to hydrochlorothiazide in hypertension	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.51549
GTEX-X4XX-0011-R5A-SM-46MWN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93833
EWS502	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.45953
colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091075
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.472412
Scleroderma_Fibroblast_GSE1724	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.12027
NDUFAF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7873
MFM-223	COSMIC Cell Line Gene CNV Profiles	1.0	4.51153
CRCGN012_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36451
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.17532
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52864
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M8-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.5579
NTHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04105
PRDX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43686
KMS27	CCLE Cell Line Gene CNV Profiles	-1.0	-1.95721
BRD-K57084585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31738
BRD-K25761766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35196
Labellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.158
GTEX-XPVG-2226-SM-4B65U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13885
SNU119	CCLE Cell Line Gene CNV Profiles	1.0	2.32874
Hip circumference adjusted for BMI	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.769897
TRIM71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16946
NUSAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80935
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19017
Pancreatic adenocarcinoma_PAAD_TCGA-F2-7276-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K85362541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27865
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
VEZT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39474
KRBA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80612
CP-320650-01-3822	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.658272
Appendix	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.943322
GTEX-RWSA-2426-SM-47JXR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61872
BRD-K68492420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36462
GSE206270_2_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chop cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.932337
MZ in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19191
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mononuclear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096644
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLR26	DepMap CRISPR Gene Dependency	1.0	3.04691
CRCGN011_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2103
Cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
TET3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37345
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01809
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.821
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE130956_0_v_3_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LCLC-97TM1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.57073
PDHA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41955
MAX	ENCODE Transcription Factor Targets	1.0	null
EWSR1_KD_GDS4962_465_human_Ewing sarcoma and prostate cancer	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
oocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.474646
HDAC2	ENCODE Transcription Factor Targets	1.0	null
TRMT44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73387
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PD 165929	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M7-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K14364923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38984
BRD-K67556876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61906
Muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.648
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20497
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC6162445__F3	PFOCR Pathway Figure Associations 2024	1.0	null
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12601
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.344
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STK24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53897
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7114
PMC8789279__F7	PFOCR Pathway Figure Associations 2024	1.0	null
Allantoic fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
BRD-K02087489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18381
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.73871
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.903012
bombesin receptor activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K41389177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34144
H3K27me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.69427
G6PC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33471
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.63215
SEC24A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87207
H3K27me3_splenic B cell_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.092952
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.307
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.671
BRD-K79213964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.05048
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H740	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.9236
Mammary Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
SW756	DepMap CRISPR Gene Dependency	1.0	3.23507
microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.119773
spanning component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.621804
GTEX-R55G-1126-SM-48FDG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16373
PMC8160578-JCB_202009147_TableS4.xlsx-MYBL2_targets-Genes_n_532_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF217	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pituitary gland tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.813
UNC119	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05018
REST_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
colonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.104002
BRD-K81925504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01141
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1545
Plasma membrane	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
MTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34274
NSMCE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33054
TUBE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6376
Medial geniculate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.646
CRCGN015_MCF10A.TP53.M_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21625
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.5095
NB4	CCLE Cell Line Gene Expression Profiles	1.0	1.91606
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MedullaOblongata	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.8714
Brain Lower Grade Glioma_LGG_TCGA-DU-6393-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Medial mammillary nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.953
Alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.306
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.4617
ARTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.31832
phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.100742
PSMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77805
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nerve	GTEx Tissue Gene Expression Profiles	1.0	0.974228
BRD-K73075421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66948
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K46001734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36056
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01756
TAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44733
Obesity	DisGeNET Gene-Disease Associations	1.0	null
embryonic fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.04885
BRD-K26612358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66776
Non-Small Cell Lung Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K57357721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84715
BRD-K39715006	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19592
G protein-coupled peptide receptor activity	GO Molecular Function Annotations 2023	1.0	null
D502MG	DepMap CRISPR Gene Dependency	1.0	2.56176
C18orf32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51478
ALDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85758
MAGED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50345
GTEX-Q2AI-1226-SM-48U14	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58605
HS600T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5821
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
membrane part	GO Cellular Component Annotations 2015	1.0	null
ATG9A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35346
hindbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.413912
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.594
496100353_HIP_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.66934
Malignant tumor of pancreas_saliva_GSE14245	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.33267
PSENEN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35899
PFAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94744
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
UBTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48919
USP2_KO_GDS5079_25_mouse_kidney	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Subrhabdomeral cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.89
CRCGN015_HEPG2_48H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.72878
Kidney Chromophobe_KICH_TCGA-KL-8326-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE172494_3_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZKSCAN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.9204
primary somatosensory cortex (area S1, areas 3,1,2)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.862313
lateral parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.972705
HDAC2_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUZ12-16625203-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.894973
SUM149PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.35011
TTC549	DepMap CRISPR Gene Dependency	1.0	2.64453
AIMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03686
Medulloblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.905
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07674
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.699
GAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16997
X, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.62451
Nucleus preopticus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.518
CL11	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3815
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.325701
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15367
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VRK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22328
kuwanon H	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.1083
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01167
heliotrine-6035	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K39411863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59404
AGAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77478
BRD-K59657378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47164
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
chondrogenic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.429165
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.1614
FASTKD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.76406
RNF135	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71105
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.883509
BRD-K75224334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53275
BRD-K91624805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7959
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.931689
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.949581
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4825
BRD-K37308886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57454
pancreatic ductal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.341863
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67262
FHIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29821
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.752
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-7502-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cytosol	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
CRCGN017_MCF10A.WT.HP_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.9062
ANKRD50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83032
GTEX-R55C-1026-SM-48FCM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15546
BRD-K12011077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37073
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.920553
GJA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97126
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24778
NUDT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79688
COV504	CCLE Cell Line Gene CNV Profiles	1.0	2.06451
EMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53761
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562	BioGPS Cell Line Gene Expression Profiles	1.0	1.09633
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KCNA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93312
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.532
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3358
ASCL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41524
BRD-K24479270	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29396
DHX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5117
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6581
XPNPEP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79944
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Hypothyroidism	CTD Gene-Disease Associations	1.0	1.03235
Brain cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
BRD-K40143134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34034
ZNF177	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35904
NETO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82402
ASXL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23051
BRD-K36134264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80263
ENSG00000286190	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65922
CDCA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67777
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18
chlormezanone-4636	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FLI1-21867929-TH2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
prostate adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.410535
MXI1	ENCODE Transcription Factor Targets	1.0	null
astroglial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.141019
paraventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23604
ZNF608	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.99953
B4GALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36205
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.22358
PFKL_OE_GDS4410_202_human_biceps	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
pyridoxine-5813	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K37049577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.876
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.344
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42067
GPCR downstream signalling	Reactome Pathways 2024	1.0	null
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K65410345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61735
MTRR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6867
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8914
Neuroendocrine tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.763
SF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7969
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74375
receptor activity	GO Molecular Function Annotations 2015	1.0	null
EPB41L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97883
Autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
Eyestalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.574
FUS-26573619-CHIP-SEQ-HEK293-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WA-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K55160477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01203
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64577478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47949
BRD-K95485901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23104
BRD-K71298594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51332
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04691
H2AZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71811
CRCGN017_MCF10A.WT.HP_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36615
intestinal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096039
CDK20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78344
MAFK	ENCODE Transcription Factor Targets	1.0	null
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21845
BRD-K20024170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11438
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.8471
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.7411
RBBP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59919
BRD-K23553911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48724
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K62852603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17356
CRCGN017_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1438
U266B1	CCLE Cell Line Gene Expression Profiles	1.0	1.38817
CRCGN015_MCF10A_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5121
MPP-89	GDSC Cell Line Gene Expression Profiles	-1.0	-1.82393
microvascular endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.115108
14982484-Table3	GeneSigDB Published Gene Signatures	1.0	null
FBXO33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47796
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64728
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2985
20460173-ImmPortCytokineReceptors	GeneSigDB Published Gene Signatures	1.0	null
BRD-K59587063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09829
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.70535
NACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47383
CWR-22 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.82
SETDB1	ENCODE Transcription Factor Targets	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100326_TCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.71101
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.54272
MM485	DepMap CRISPR Gene Dependency	1.0	4.28207
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51244
Rectum adenocarcinoma_READ_TCGA-AG-4021-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_4 mos_M_12889	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13359
NMB cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.678
CRCGN015_HEPG2_48H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.42688
Lung squamous cell carcinoma_LUSC_TCGA-98-A53H-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bronchogenic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.956428
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-X6-A8C2-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
INHBE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72965
REH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K13267677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0857
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.31586
posterior (caudal) superior temporal cortex (area 22c)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29448
U-138MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.684
regulation of respiratory gaseous exchange	GO Biological Process Annotations 2023	1.0	null
positive regulation of interferon-alpha production	GO Biological Process Annotations 2025	1.0	null
WASHC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29103
GTEX-N7MS-0126-SM-3TW8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85784
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8519-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREM	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9774
PTPN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05964
Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
antiviral innate immune response	GO Biological Process Annotations 2023	1.0	null
IZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.830383
NRF1	ENCODE Transcription Factor Targets	1.0	null
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71622214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.35069
BRD-K05002317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24803
IFT80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42988
WNT1	MSigDB Cancer Gene Co-expression Modules	1.0	null
BRD-K69408624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69143
CD164L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0444
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CRCGN015_MCF10A.WT.HP_24H:M16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.0021
BRD-K75220555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16516
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058733
KIZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46488
JUND	ENCODE Transcription Factor Targets	1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01492
asiaticoside-7244	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K70343553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40093
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.305722
SLR26	Achilles Cell Line Gene Essentiality Profiles	1.0	1.41783
NCBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54547
positive regulation of osteoclast proliferation	GO Biological Process Annotations 2025	1.0	null
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20747
TBC1D14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8319
heterotrimeric g-protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.241716
fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.946947
VRK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68677
CRAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23729
PEX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50668
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AE-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06442
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H1563	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K14695950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24058
Claustrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
SUPT5H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.1279
BRD-K76680796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51367
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4924
BRD-K71177762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15656
H3K4me1_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49584
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
wortmannin-2703	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NRF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16908
cerebellar cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.971562
defense response to virus	GO Biological Process Annotations 2025	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11C-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80469338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95515
LIN28B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27911
BRD-K74862734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22333
Erectile dysfunction_Penis Erectile Tissue_GSE2457	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.62201
Prostate adenocarcinoma_PRAD_TCGA-KK-A59V-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K70979181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12433
SKRC31	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53477
Lung squamous cell carcinoma_LUSC_TCGA-43-7658-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
astrocytoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076653
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6727
Sarcoma_SARC_TCGA-DX-A23Y-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837792
BRD-K65250438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50978
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10684
Heterotrimeric G-protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.244
USP31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33971
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32454
Prostate adenocarcinoma_PRAD_TCGA-EJ-5509-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80424876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81469
POU3F2	ChEA Transcription Factor Targets	1.0	null
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.856411
G118	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.02518
pituitary gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.142546
positive regulation of multicellular organismal process	GO Biological Process Annotations 2023	1.0	null
cytoplasmic side of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.241356
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.22864
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90997
prostate gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.395709
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.841997
ANAPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20518
MRPL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10517
NIPAL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86076
NCI-H358 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.514
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5353
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22848
Skin Cutaneous Melanoma_SKCM_TCGA-W3-A825-06A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A7UZ-01A-12R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDKN1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73634
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5014
integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
U343	Achilles Cell Line Gene Essentiality Profiles	1.0	1.1289
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.999273
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
Brain_CT2_CGE 286	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	1.0	null
FHL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.18539
CRCGN011_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1065
ATCAY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25933
Brain Lower Grade Glioma_LGG_TCGA-S9-A7J1-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE186647,GSE217288_1_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
FAM124B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29935
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV6-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.125
Prostate adenocarcinoma_PRAD_TCGA-G9-6348-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.16955
ventrolateral prefrontal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2013
CRCGN015_MCF10A_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.7044
Rectum adenocarcinoma_READ_TCGA-CI-6619-01B-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrointestinal stromal tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.226
GTEX-XMD1-0011-R8A-SM-4AT48	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18832
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
OE33	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K68257399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27745
Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78015598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47649
BRD-K01362004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57587
Brain Lower Grade Glioma_LGG_TCGA-HT-7680-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE117643_1_v_0_irx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SALL4	ChEA Transcription Factor Targets	1.0	null
NOMO-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.44899
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971911
FU97	DepMap CRISPR Gene Dependency	1.0	4.11548
CNOT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.585
magnocellular (medial) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27434
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JD-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9CV-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
[125I][TYR4]BOMBESIN	DGIdb Drug Targets 2026	1.0	1.3233
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.251718
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Pancreatic acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.895
NDUFB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76777
GTEX-RN64-2326-SM-48FDW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52959
BRD-K80733946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44258
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
SLC35A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50392
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13359
Prostate adenocarcinoma_PRAD_TCGA-G9-6365-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3704
IZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.939427
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2061
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_4day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.51009
TBRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5025
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pituitary gonadotropin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.495
non-small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066195
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6823
L428	CCLE Cell Line Gene CNV Profiles	1.0	1.94641
BRD-K16727544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32615
IGFBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56968
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12601
KLC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84727
ACN	GDSC Cell Line Gene Expression Profiles	-1.0	-1.668
BRD-K58324650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08164
TIGD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26068
ANKRD65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91072
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68497
TAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.795
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.05135
BRD-K31021810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26664
ATOH7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56848
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A5Y1-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
TUFM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30988
MGAT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5328
PRDM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86061
NCI-H727 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.684
GM1600	BioGPS Cell Line Gene Expression Profiles	1.0	1.19864
Heart	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.877
TMX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61743
Brain Lower Grade Glioma_LGG_TCGA-DU-7309-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K35681049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28462
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907947
BRD-K19103068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32751
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4499
HINFP	JASPAR Predicted Transcription Factor Targets	1.0	null
ATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3624
GON4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76766
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50735
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.937637
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.54892
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
similar	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4874-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-SJXC-0326-SM-2XCFI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0228
SKNO1	CCLE Cell Line Gene CNV Profiles	1.0	1.38964
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8854
NFKBIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43497
BRD-K72835476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16318
ZNF835	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37121
OVCA420	DepMap CRISPR Gene Dependency	1.0	3.18393
CTCF_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5807
IMPDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84758
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.5783
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.94784
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8XJ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lung small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.447687
BRD-K29898553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07125
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.931831
endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.062307
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K51181201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13664
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
PMC11982601-IMM-175-84-s005.xlsx-Fig5D_LPS-Innate_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.465723
EFCAB6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83109
AICD_Induced  expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
SMARCA4	ChEA Transcription Factor Targets	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.461
BRD-K78106941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17922
CRCGN017_MCF10A.TP53.M_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13989
Perturb_4427_KO_Eed_SRP172483	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.62806
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23551
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8843
RL952	CCLE Cell Line Gene CNV Profiles	-1.0	-1.90976
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.707565
MZ in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02986
BRD-K12397820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6951
Rectum adenocarcinoma_READ_TCGA-EI-6509-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
SPSB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54063
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.363
MDAMB453	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.3529
ATP8B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61696
GABRE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02719
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03837
Weight Loss	CTD Gene-Disease Associations	1.0	1.40705
MDAMB415	DepMap CRISPR Gene Dependency	1.0	2.40979
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8936
Lung squamous cell carcinoma_LUSC_TCGA-94-7557-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47482563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14552
regulation of interferon-alpha production	GO Biological Process Annotations 2023	1.0	null
REST_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5028-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brain endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.190032
ZNF629	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46768
Lung adenocarcinoma_LUAD_TCGA-44-6148-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K33986892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4627
hsa-miR-921	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
APLP2_KO_GDS4414_534_mouse_adult cortex	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND	JASPAR Predicted Transcription Factor Targets	1.0	null
SNU5	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59064
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35673
BRD-K87602457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02261
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
C8orf33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53003
BRD-K40210962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67592
pancreatic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.158422
g-protein coupled receptor activity	GO Molecular Function Annotations 2015	1.0	null
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ovary cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077088
BRD-K01237500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.69896
ZBTB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29154
GTEX-NPJ7-0011-R5a-SM-33HBK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01645
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4425
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6934-11A-01R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.28
GUCA1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81151
TMEM178A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37969
BRD-K76885311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91523
Golgi cis cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.656
CRCGN015_MCF10A.WT.HP_24H:K18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46098
sneeze reflex	GO Biological Process Annotations 2023	1.0	null
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22287
TST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57569
osteoclastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.964199
BRD-K08534346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1266
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.02507
BRD-K72609226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67792
LRP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.87587
Brain Lower Grade Glioma_LGG_TCGA-DB-5279-01A-03R-2347-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EVSA-T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
lymphocytic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.305361
semen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.159687
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16522
BRD-K86285108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39671
D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Nal-NH<sub>2</sub>	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
INTS12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03548
BRD-K64827406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49433
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4112
GASTRIN RELEASING PEPTIDE(14-27) (HUMAN)	DGIdb Drug Targets 2026	1.0	1.3233
MACO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24527
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.6513
ST486	CCLE Cell Line Gene Expression Profiles	1.0	2.37103
TGW	COSMIC Cell Line Gene Mutation Profiles	1.0	null
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17465
GGCX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84393
496100393_HIP_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.68314
Cardiomyopathy, Dilated_Myocardial tissue_GSE3586	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.34183
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.97682
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
glioblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081419
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.782776
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5091
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.671
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48299
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6486
GADD45A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62108
Rectum adenocarcinoma_READ_TCGA-AG-3732-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9314343-41467_2022_31892_MOESM8_ESM.xlsx-Fig7e-CTCF_in_promoter_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.484376
Gastric antrum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.897
ZNF658	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65731
Mimosine	CTD Gene-Chemical Interactions	1.0	null
GATA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.082
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05999
BRD-K22474245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51378
PAX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98138
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9032
GSE60837_0_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.459
MTFR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39872
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3N_Peaks_YAP1FAM118B_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.87917
GRP	Guide to Pharmacology Protein Ligands of Receptors	1.0	null
ZRANB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14437
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5774
SUZ12-20075857-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K80198069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44078
limitans nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.948536
CRCGN009_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.26939
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.918271
PDSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86605
BRD-K02403042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28222
malignant	GeneRIF Biological Term Annotations	1.0	null
ASPC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ovary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065893
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6939-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TSPAN17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57978
CLTC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36805
GTEX-UPIC-0226-SM-3GADO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850129
PMC3360606__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GRINA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52737
SIRT6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.463
CRCGN012_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.55825
HLX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98542
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K64264170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16662
BRD-K01910220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17398
TBP	ENCODE Transcription Factor Targets	1.0	null
TRIM28_knockout_301_GSE32224	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.41574
BRD-K27621887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37083
Secondary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.56
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0198
BRD-K18402224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74102
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.67457
hypoxiainducible	GeneRIF Biological Term Annotations	1.0	null
GTEX-XMD1-0011-R3B-SM-4AT5R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.832804
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cuneus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02361
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19555
adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.074546
Cpa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.64
heart	GTEx Tissue Gene Expression Profiles	-1.0	-0.953383
Cranial ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.3
SEC14L5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73779
BRD-K65496998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26431
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.654
biological_process	GO Biological Process Annotations 2015	1.0	null
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941819
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5993
BRD-K46913557	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3002
Adenohypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.985
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7858
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33399
BRD-K73210450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.70267
LRAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2626
CRCGN015_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09415
B3GAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07339
BRD-K14719962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55069
UQCRH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5788
GPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13528
LKAAEAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52222
FKBP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82367
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.83404
BRD-K14499901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65525
RSBN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85568
1,6-hexamethylene diisocyanate	CTD Gene-Chemical Interactions	1.0	null
macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.12304
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE211931_0_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84617
PNMA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33087
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3091
BRD-A63704386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25095
Colonic epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.954817
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.329
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52085
BRD-K09487932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.025
PMC4063835-epi-9-760-s02.xls-MI_vs_NU-SYMBOL_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93337444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32453
NOBOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36428
Brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
BRD-K74842791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01408
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.375368
FBRSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82069
VIPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18466
KU-19-19	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TE617T	CCLE Cell Line Gene Expression Profiles	1.0	1.781
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AR4-2J cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.491
CTCF	ENCODE Transcription Factor Targets	1.0	null
GALT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62708
periventricular nucleus, preoptic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19734
ChIP_H3K27me3_17603471_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39885
Sarcoma_SARC_TCGA-WK-A8XS-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU1076	DepMap CRISPR Gene Dependency	1.0	8.04193
KMS-28PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05754
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5329-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.76724
FOSB::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1277
LPAR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26599
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067116
UBALD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87046
astroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.139248
RAB11FIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97782
allantois	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.221989
skimmianine-5766	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60941
H3K27me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.57825
posteroventral (inferior) parietal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12128
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30013
CACTIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15517
PAQR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03542
KP2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37068
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26604
CAPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29796
PRXL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79012
TUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56784
bcl11b_18199763_brain_lof_mouse_gpl1261_gds3178	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.885081
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.57644
BSPRY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82643
MYEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94728
SALL4-22934838-CD34+-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.4898
KDM2B-26808549-CHIP-SEQ-REH-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CLDN18_KO_GSE48443_44_mouse_lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
EXOSC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78429
H3K4me1_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RUNX2	ChEA Transcription Factor Targets	1.0	null
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07153
TMED3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27661
MYL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4111
GTEX-T6MN-0011-R8A-SM-32QP3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935617
BRD-K37071891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23516
MDH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10834
NFE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26878
ZNF841	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87216
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47888
GM97	BioGPS Cell Line Gene Expression Profiles	1.0	2.41473
VPS26A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09955
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3641
BRD-K96096022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42344
outer CP in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.987776
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SH3BP5L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98752
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5374
TAF7	ENCODE Transcription Factor Targets	1.0	null
S117	DepMap CRISPR Gene Dependency	1.0	2.17721
positive regulation of leukocyte proliferation	GO Biological Process Annotations 2025	1.0	null
ERBB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5018
BRD-K69337311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12721
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.893612
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4729
ORMDL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46607
Pancreatic ductal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.935
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6960-01A-41R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM87B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38881
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.75092
cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046923
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
NCIH1299	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.77128
BRD-K75038114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85603
IER5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0834
BRD-K68705041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77809
BRD-K64393896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4269
CRCGN017_MCF10A.WT.HP_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39698
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6828-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.04255
respiratory epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.456055
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.152144
BRD-K62152527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38876
AXIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30095
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04183
Lung adenocarcinoma_LUAD_TCGA-97-8552-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K02361314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.69693
HNT34	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37348
BRD-A73618687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42496
PMC8985862-Table3.XLSX-OTP-BRCA1_OTP	Rummagene Transcription Factor Associations 2026	1.0	null
SOGA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66905
BRD-K94751306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01232
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13487
CEBPB-26923725-CHIP-SEQ-MESODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H1993	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EYA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99955
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.2872
BRD-K72588970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78871
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14426
H3K27me3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRPF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49453
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K76173551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41404
BRD-K83238251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65638
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.921914
ovary	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.950622
EPHA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6611
Brain Lower Grade Glioma_LGG_TCGA-QH-A6X8-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39592
DDX21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09039
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.48961
PMC8423434-mmc7.xlsx-KLF4_HENSM-Genes_n_2172_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K94540403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15884
Brain Lower Grade Glioma_LGG_TCGA-HT-7473-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RING1B-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.138622
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.5962
Brain Lower Grade Glioma_LGG_TCGA-DU-A76R-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.6408
PL45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.846778
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
XIAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23656
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3EV-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.20166
CRCGN010_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.47372
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.332661
Prostate adenocarcinoma_PRAD_TCGA-CH-5763-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF440	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33234
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49617
Leydig cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.006
vascular endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067599
USF2	ENCODE Transcription Factor Targets	1.0	null
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.79815
BRD-K59324446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.93399
Sarcoma_SARC_TCGA-DX-A3UC-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.25921
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mononuclear phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.115516
heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061652
Spinal cord	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.121
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.37889
SCARF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0346
RFT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92393
HOUAI	DepMap CRISPR Gene Dependency	1.0	2.22064
ELF1	ENCODE Transcription Factor Targets	1.0	null
BLOC1S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68749
C6 glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.15
Calu-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
IL4R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.74252
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.385
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29244
PRELID1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08686
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20853
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K60430317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53502
ncm-460 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.24922
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4999-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50677542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48694
SP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07916
Cell periphery	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7894
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIOBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56286
VMRCLCD	CCLE Cell Line Gene CNV Profiles	1.0	1.77835
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43825
striatum_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3428
head of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.913623
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24931
Cranial nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.401
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1271
FN3K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64767
Brain Lower Grade Glioma_LGG_TCGA-HT-7691-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9252
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83755051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00755
F36P	CCLE Cell Line Gene CNV Profiles	1.0	1.6692
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2574
CHD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68981
NREP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79479
NCI-H810	COSMIC Cell Line Gene Mutation Profiles	1.0	null
central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043409
BRD-K10704442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18396
Lung adenocarcinoma_LUAD_TCGA-38-4627-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15723
glia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.167395
496100647_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.00862
CD105+_Endothelial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.986206
FOXO3	ChEA Transcription Factor Targets	1.0	null
BRD-K51446586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14633
BRD-K65086352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18531
ATM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67878
Prostate adenocarcinoma_PRAD_TCGA-EJ-5507-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain_CT2_CGE 286	HuBMAP ASCT+B Annotations	1.0	null
H3K27me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EKVX	GDSC Cell Line Gene Expression Profiles	-1.0	-1.64713
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055398
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.65082
Sarcoma_SARC_TCGA-WK-A8XQ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DKMG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54374
BRD-K47283018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00688
epidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.916236
MLEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76652
H3K27me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24694
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A2-11A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
bantag-1	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
BRD-K03057797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46964
CRCGN015_MCF10A_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.33934
pancreatic ductal carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.311507
GSE136869_1_v_0_lpar2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A-VN-1203-2004(H5N1)_Day4-10^4pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.75366
HCFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14239
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47127
POLRMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84835
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.34016
RAGE_knockout_268_GDS3755	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.56725
CYB561A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49074
NCIH1963	CCLE Cell Line Gene Expression Profiles	1.0	1.47627
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6ME-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE240027,GSE240030_5_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.02627
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1349
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08998
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.42783
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.39475
Prostate adenocarcinoma_PRAD_TCGA-EJ-7785-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Human - Motor Cortex - Cross-Species Cluster - Lamp5+ GABAergic neuron_5	HuBMAP Azimuth Cell Type Annotations	1.0	null
BRD-K29301364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12943
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.82716
SIX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8466
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H-1299	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.588
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040422
ANKRD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34717
BRD-K76922696	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99265
integral component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K49872883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11474
Contact dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
HCV_8week+IFN-a_None_GSE37715	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.76511
PDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00675
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine luminal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.901
BRD-K13257316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62187
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.72672
USF2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6471792__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855226
DMWD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50404
HCA-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.63137
IL27RA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54101
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.329
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990797
CRCGN017_MCF10A.WT.HP_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01282
SSU72	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8657
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30917
CRCGN016_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.5601
CRCGN012_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59703
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCNG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87226
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03927
BRD-K17659275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46876
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.671
negative regulation of cytokine production	GO Biological Process Annotations 2025	1.0	null
salbutamol-3677	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
cho cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.18168
GTF2IRD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02323
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TJP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88433
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02928
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
SLC19A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4521
BRD-K99028283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2634
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.95039
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.457
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
CRCGN011_HEPG2_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.041
Retinal vascular caliber	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.6
bone marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.125234
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
neuroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.315498
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37861
H3K4me1_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.78118
deferoxamine-4317	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.550106
abducens nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39516
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5461
H3K27me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9934
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.228764
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03025
SARS-BatSRBD_Day4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.6276
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3185
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.855134
NERF2-26677805-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BCLAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0053
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
GTEX-QDT8-0011-R6A-SM-32PKI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37293
ZNF735	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03014
modest	GeneRIF Biological Term Annotations	1.0	null
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.841782
Lung adenocarcinoma_LUAD_TCGA-55-6978-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7495487-41598_2020_71030_MOESM2_ESM.xlsx-Sheet1-NR1A1_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26932
BRD-K33044659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99311
MEGF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.72004
HAPSTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53655
RPL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01366
BRD-K31805261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03893
ncih727	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.633
Myometrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.336
BRD-K49419779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64363
STAT5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43923
DoTc2-4510	GDSC Cell Line Gene Expression Profiles	1.0	1.79987
Liver	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.12554
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.23141
Gastrinoma	DisGeNET Gene-Disease Associations	1.0	null
EZH2-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.870144
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0911
Medulloblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.059
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FU-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.32371
intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.74582
JHOS2	CCLE Cell Line Gene Expression Profiles	1.0	1.48194
Signal Transduction	Reactome Pathways 2014	1.0	null
BRD-K68383485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04168
positive regulation of respiratory gaseous exchange	GO Biological Process Annotations 2025	1.0	null
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40025
REST_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L88	GDSC Cell Line Gene Expression Profiles	1.0	1.7968
NCIH660	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.87993
TMEM256	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62057
BCL2L10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84519
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.591
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.47901
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04251
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LE-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
GI-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-X585-0011-R5A-SM-46MVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63371
JHESOAD1	DepMap CRISPR Gene Dependency	1.0	2.47666
BRD-K97064059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51981
SLC25A38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80449
etiocholanolone-3639	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PFKL_OE_GDS4410_75_human_Biceps muscle	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K44078665	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98599
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.83917
REST_Panc1_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.0577
BRD-K22390389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47091
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.25651
GSE190681_1_v_0_rtcb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48388
FAM83D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55918
SMARCA4-23332759-OLIGODENDROCYTES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
TM6SF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09518
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22932
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.846182
BRD-K40292034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31583
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9326
BRD-K97067262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8267
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.73797
CRCGN011_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6168
CEBPA-26348894-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Poisoning	CTD Gene-Disease Associations	1.0	1.02447
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6966
LN-229	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09747
H4C7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84916
conceptus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.470375
Median nucleus of thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.18
Temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.729
PAX3	ChEA Transcription Factor Targets	1.0	null
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35579
PDGF_ERK_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
OGFOD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14849
mestranol-4792	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RARA_01_51	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.57347
Water vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
E2F2_KD_GDS4094_447_mouse_Mammary tumors (Myc-induced)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K48782834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9309
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
globose nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.933516
endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062008
SIX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91708
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.63692
AIRE_KO_GDS2274_246_mouse_Medullary thymic epithelial cells (with high CD80 expression)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.7227
WDR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84958
NR3C1	ChEA Transcription Factor Targets	1.0	null
MALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17024
phospholipase C-activating G protein-coupled receptor signaling pathway	GO Biological Process Annotations 2025	1.0	null
CRCGN015_HEPG2_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.91394
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.087
RAD54B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44265
COL7A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50099
clonidine-3172	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
INO80C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.44033
nmb	GeneRIF Biological Term Annotations	1.0	null
EPB41L4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09882
BRD-K46293468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2544
Infratentorial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
ZBTB32	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8056
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848219
BRD-K87261428	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49411
Breast Cancer_Mammary Gland Tissue_GSE1378	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-2.74067
BRD-K60837711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18012
HSC3	CCLE Cell Line Gene Expression Profiles	1.0	1.92446
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.50717
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A6C5-11A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKMM2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36329
BRD-K78238858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63587
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Y-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN012_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7695
GF1-26923725-CHIP-SEQ-HPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
NHLRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46728
AKAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34636
MIEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30771
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.55644
C6orf141	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80187
MAMDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3081
HEYA8	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.20774
UT7	CCLE Cell Line Gene CNV Profiles	1.0	1.50219
BRD-K96449536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10681
BRD-K78886448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92644
NCIH1299	CCLE Cell Line Gene CNV Profiles	1.0	1.34067
molecular transducer activity	GO Molecular Function Annotations 2015	1.0	null
KLHL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54109
PMC9296003-supp_gad.348982.121_Supplementary_Table_S1.xlsx-Partitions_EPC1-PHF1-FLAG-Unnamed_20_PHF1	Rummagene Transcription Factor Associations 2026	1.0	null
REST_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96348
MYLIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78238
USP2_KO_GSE43517_20_mouse_kidney	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HCC1143	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58221
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27398
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SARC9371	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A264-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bone cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.494136
GSE140651,GSE140653_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07153
Necrosis	CTD Gene-Disease Associations	1.0	1.23712
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.927705
TAF9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71826
CAMSAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27397
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.73872
MED6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42717
KLF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93218
GSE135359_0_v_1_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLITRK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.87964
germ cell cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.215992
TYK2_KD_GDS4754_158_human_JURKAT	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SAP25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02174
embryonic fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.182862
CRCGN017_MCF10A.WT.HP_24H:C02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09985
GSE77108_5_v_1_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
terazosin-6092	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ChIP_EZH2_18974828	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K07697589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05569
stratum pyramidale of caudal CA3	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.899429
BRD-K78306305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19885
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.37995
CCDC152	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61193
inferior olivary complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.961767
posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20912
BANTAG-1	DGIdb Drug Targets 2026	1.0	0.8822
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843173
CRCGN014_HEPG2_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.30019
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.40911
GTEX-QDT8-0011-R4A-SM-32PKM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839558
CRCGN010_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70637
BRD-K39140255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18997
outer SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08456
NUDT5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22924
MAGOH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85112
SOCS3_DELETION_GDS1254_80_mouse_ES (embryonic stems cells)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BRD-K67591072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89806
MRTFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94999
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
side of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.139466
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.46395
BRD-K17133642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78078
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.894094
TWF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6385
hypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.260606
TOP2B-26459242-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ZNF324	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5757
ING3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12815
Lung adenocarcinoma_LUAD_TCGA-55-6972-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.0456
GTEX-S7SE-0011-R2A-SM-2XCDC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841631
TCF12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950655
A2780	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99565
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
daoy cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.648127
BRD-K59149254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08659
Thymus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.07565
BRD-K61134709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32283
FKBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41318
PMC9314343-41467_2022_31892_MOESM8_ESM.xlsx-FigS7d-CTCF_in_promoter_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal body temperature homeostasis	MPO Gene-Phenotype Associations	1.0	null
STK17A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71723
Neuroendocrine tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.852
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.24785
HMBOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1941
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.703
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51128
esophagus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.41848
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947526
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.86606
biological regulation	GO Biological Process Annotations 2015	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A726-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3431-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BOMBESIN	DGIdb Drug Targets 2026	1.0	1.3233
REST_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARMCX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22124
RAB40AL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.38029
REST_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26067
Ileal carcinoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.172
integral component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.187646
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
TemporalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.11091
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.835737
SNU620	DepMap CRISPR Gene Dependency	1.0	2.70671
BRD-K24343201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83506
L1TD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13293
glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.73803
Neuroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.307
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
SMS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1784
superior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03422
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.96941
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.962516
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.12605
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K91564773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32761
PBDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7422
GT1-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.836
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.1877
OPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53061
Urophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8055
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46429
BRD-K22246901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13696
MRPL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08904
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01827055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35577
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
ASL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55131
CAOV4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53598
RCOR1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85292767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20076
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.5929
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.45816
AFAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80874
RBM45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65375
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040665
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32096
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.8107
NHERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2348
TPP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.54361
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26571
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.728
FKBP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57176
NDUFS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27036
SOCS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8597
ZFHX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.7075
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.87182
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KDM4A	ENCODE Transcription Factor Targets	1.0	null
potency	GeneRIF Biological Term Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-MR-A520-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84800135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08377
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5706-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neuromedin B (1-30) (human)	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
DDR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00068
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_K27me3_17603471_mouseMEF	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
CLINDAMYCIN-PO4	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72225
BRD-K63107801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5526
hippocampus (hippocampal formation)_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.825613
CLDN18_KO_GDS4961_28_mouse_whole lung tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
ITGA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25572
H3K27me3_mammary epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69465
BSX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40982
SEC11C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15685
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.921882
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEXB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09253
PEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51482
Mesothelioma_MESO_TCGA-LK-A4O7-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ONECUT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38701
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.22724
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.943501
CLCN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44025
GTEX-UPIC-1826-SM-4IHKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23362
colonic epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.450271
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3PL-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
primary visual cortex (striate cortex, area V1/17)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07503
BRD-K60653414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05373
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
[D-PHE6, LEU13, CPA14,&PSI;13-14]BOMBESIN-(6-14)	DGIdb Drug Targets 2026	1.0	1.3233
REST_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-0126-SM-48TZE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62566
l35	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.544
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.053
mediodorsal nucleus of thalamus_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.03228
BRD-K25608271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12012
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.851245
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24702
CRCGN012_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77985
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
A-VN-1203-2004(H5N1)_Day2-10^4pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.8973
CFPAC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.669
DYNLT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39557
ZBTB18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86659
EBF1	ENCODE Transcription Factor Targets	1.0	null
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.897745
Birth weight	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.25229
NCI-H1299	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.25988
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6765
BRD-K15907840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3671
REST_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K57356416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15382
NCO2	CCLE Cell Line Gene CNV Profiles	1.0	1.54605
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.892
CHRNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8056
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.082187
CYTH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97257
BRD-K22471908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27916
LNZ308	CCLE Cell Line Gene Expression Profiles	-1.0	-2.33226