association	dataset	threshold value	standardized value
GSE112760,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53319404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81817
GSE102486,GSE102490_1_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4224449-pone.0112193.s009.xlsx-PPI_MODULES_CLEAN_MAP_merg_OUT-Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ouabain (Octahydrate)_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0171869
NKG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51265
Advanced sleep phase syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.58
GSE232261,GSE232263_0_v_1_usf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9714459-DataSheet3.xlsx-Supplement_3A-1166_common_elements_in_MSC_and_Fibroblasts_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_24hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZSCAN18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40657
GSE232631_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11409756-13062_2024_533_MOESM1_ESM.xlsx-Sheet1-Table_S1_Differentially_expressed_genes_DEGs_regulated_by_ZFP64_through_mRNA-seq_ZFP64	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF605	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07534
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217452_2_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of gene expression	GO Biological Process Annotations 2023	1.0	null
PMC4728380-ncomms10153-s8.xlsx-MYC_binding_intensity_ALL-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE100102_0_v_3_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Pemetrexed_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0120716
NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.25351
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212842
BRD-K57382977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37884
Agranular insular cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.951
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE144484_2_v_1_mllt6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE240645_1_v_0_u90926_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF526	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38252
GSE131649_2_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KASUMI1	DepMap CRISPR Gene Dependency	1.0	2.86066
BRD-K87593103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58214
GSE206270_2_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120413,GSE120447_0_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE96641_3_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
igr1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.045
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8125
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.8281
DNA-templated transcription	GO Biological Process Annotations 2025	1.0	null
BRD-K23280067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02719
PMC10794847-mmc2.xlsx-PBRM1_KD_up-Table_S1_Differentially_expressed_genes_with_PBRM1_knockdown_in_the_progenitor_state_Related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K97943226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20824
BRD-K83603369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9274
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4087
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.212
GSE188832,GSE188835_0_v_1_irf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE168076,GSE168080_1_v_0_batf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.3305
MCF7_Ki8751_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168354
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.298971
BRD-K36465335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31257
BRD-K11545984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39858
Adult acute lymphocytic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.265
CRCGN014_HEPG2_3H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27231
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144052
PMC5503627-oncotarget-08-39497-s003.xlsx-hypo_in_shUHRF1_KD-Unnamed_7_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204661
TAK-901_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0177208
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216273,GSE216292_0_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K05970499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01164
BRD-A06837695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19797
GSE136232,GSE136234_0_v_1_zpbp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223893_4_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K15285842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75476
BRD-K12181036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09033
BRD-K81954791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13603
PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_13_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11058205-42003_2024_6202_MOESM6_ESM.xlsx-Data3b_DirectGene_FOXA1-Data3b_Genes_directly_regulated_by_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8033524-EMMM-13-e13162-s004.xlsx-d_GREAT_on_NFIB_bound-genes_HF-Unnamed_0_NFIB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_5_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76628522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.67998
Proventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
GSE151119_2_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K58964288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41716
GSE211177,GSE211178_4_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE91015_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Ruxolitinib_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00940982
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23975481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72572
Palpus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.647
New mitotic spindle pole body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.629
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70896
BRD-K15907840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90367
response to lipid	GO Biological Process Annotations 2023	1.0	null
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8283158-mmc2.xlsx-TCF4_Glut-Gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
U118MG_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	3.14941
GSE196699_7_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K38710631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04923
BRD-K34158806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33312
MCF7_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196538
USF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0609
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE150669_2_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
APELA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35762
MCF7_AMG-900_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130622
GSE193999,GSE194000_3_v_2_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135514_8_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Tacedinaline_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165434
MCF7_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205614
BRD-K39390441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56376
GSE130401_6_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:A10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00192
GSE226285_3_v_1_nr0b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE95182_0_v_1_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE175920_4_v_2_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mRNA stabilization	GO Biological Process Annotations 2023	1.0	null
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE223287,GSE223290_2_v_4_braf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE223241_1_v_3_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75649446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49412
BRD-K37151525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30751
Homoharringtonine_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0248116
PMC12494973-41467_2025_63880_MOESM1_ESM.pdf-168-KLF4_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210225_0_v_1_uba6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	1.0	1.51972
Developmental disorder of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.579
BRD-K26024910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51261
Nevirapine_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00552314
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Semitendinosus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.557
BRD-K20245846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11684
GSE151829,GSE151831_1_v_0_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171712_0_v_1_scgb1a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K79232672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26631
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1737
GSE164757,GSE164759_4_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MAP3K21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2259
CHST1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.62905
BRD-K12864860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77775
PMC10679662-mmc2.xlsx-NC-D5-ZEB2-siRNA-Upregulated-Gene_Symbol_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE156978_1_v_0_dnmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE81803,GSE81912_4_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157594_6_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.5118
CRCGN017_MCF10A.WT.HP_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1751
Intracellular organelle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE199034_1_v_2_pirfenidone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A03997826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14971
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46845
COV434	DepMap CRISPR Gene Dependency	1.0	2.92471
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.21603
GSE70499_4_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11333005-ppat.1012426.s020.xlsx-ISGs_IFNb_up_IRF9-indep_8dpt-ENSEMBL_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K09903493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21471
A549_Abexinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118251
GSE203158_12_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Gallic acid (hydrate)_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00592691
MITF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7392
GSE160246_0_v_5_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_11_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.91045
GSE87404,GSE87812_1_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K39267096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82002
GSE174522_1_v_0_spp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JVM3	DepMap CRISPR Gene Dependency	1.0	2.32361
GSE217541,GSE217543_0_v_1_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9185
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.240694
GSE148010,GSE148120_3_v_2_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199606_1_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Apicoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.611
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K44984558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76702
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101239_4_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE88819_0_v_10_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE70499_5_v_2_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE98898_4_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92759025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0792
Ivabradine (hydrochloride)_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0284842
Neurula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.554
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
BRD-K20810649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16705
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9422
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Entecavir (monohydrate)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0145559
GSC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0882
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211474,GSE212779_0_v_1_phf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
T-cell adult acute lymphocytic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.42
Harringtonine_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0146555
A549_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188482
Hydroxyfasudil_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0161257
BRD-K18594025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60311
GSE157594_5_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Tranilast_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0110052
Height	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.622185
GSE138818_1_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14070721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74
MCF7_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128396
BRD-K13968264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16964
CTCF-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K64393896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00341
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.57858
GSE180200,GSE180201_15_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76985713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74391
response to lipopolysaccharide	GO Biological Process Annotations 2025	1.0	null
PMC11390959-41598_2024_70075_MOESM3_ESM.xlsx-520_DMD_common_down_gene_list-HES4_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
PITX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7443
TNFAIP8L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19945
GSE238018_1_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147613_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE121198,GSE129779_0_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196110_1_v_2_ndrg3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NAMALWA cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.613
GSE128730_4_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195582_3_v_1_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8175556-42003_2021_2140_MOESM6_ESM.txt--FOSL2_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
TSG101	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46881
regulation of mRNA stability	GO Biological Process Annotations 2023	1.0	null
TCF21-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
GSE136627_3_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE232223_1_v_0_letmd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nucleus preopticus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.722
JUN-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19495
GSE210911_1_v_0_crem_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
NAP1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04846
YAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44999
GSE132948,GSE132949_0_v_1_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124410_3_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146253_0_v_5_stat4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112761,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239891
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K90962922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02846
Brain - Hypothalamus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.6716
GSE143643,GSE143644_4_v_5_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11333005-ppat.1012426.s020.xlsx-ISGs_IFNb_up_IRF9-indep_3dpt-SYMBOL_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233183,GSE233187_3_v_6_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tailbud stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.779
GSE169571_3_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DCPS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28621
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Stomach	GTEx Tissue Gene Expression Profiles 2023	1.0	1.31745
MCF7_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145562
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4276
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFKB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2875
Chylomicron	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.634
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_significantly_downregulated_739_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUPT7L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09802
BRD-A19766589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02912
PMC8755441-mmc3.xlsx-IRF1-UP-encode_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
NADP metabolic process	GO Biological Process Annotations 2023	1.0	null
MCF7_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00897285
GSE90710_1_v_0_med13_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166714
BRD-K18527484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23532
BRD-K76543697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0351
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K41206520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03365
BRD-K54732353	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01987
GSE202284,GSE202289_12_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11839199-CPR-58-e13746-s001.docx-2-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
GSE98898_7_v_2_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8038
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5505
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K99944747	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18031
GSE158431_2_v_3_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73581966	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6459
A549_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131875
BRD-K12749985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00529
GSE143643,GSE143644_4_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ARID5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17956
CORL47	DepMap CRISPR Gene Dependency	1.0	3.16021
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5727
BRD-K37637965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35859
GSE214596,GSE214598_1_v_3_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K60531990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05501
Ralimetinib dimesylate_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0139753
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.4254
496100582_HIP_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.10055
GSE220914_1_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mitochondrial degradosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.806
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6539
K562_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0253745
GSE211128_2_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A43330902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04686
GSE221020,GSE221023_2_v_0_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9950457-mmc3.xlsx-AP2A_binding_sites_GRHL2_KO-LRRC32_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K22447639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30157
GSE112761,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HSD17B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1364
GSE125211_2_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
FASN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4528
GSE179974_3_v_0_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K78712486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02857
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE221327_1_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE147626_2_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FKBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07388
NUP93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24371
CRCGN017_MCF10A.WT.HP_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9114
RIOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16279
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
NNT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94132
RPL31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13927
Abetalipoproteinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.132
GSE116354,GSE117379_3_v_5_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ACTN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09836
ZDHHC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32938
Baicalin_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0257943
docebenone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80685
GSE129244_0_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CCC5	DepMap CRISPR Gene Dependency	1.0	2.59169
HCFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49462
GSE233049_1_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12178829-mmc4.xlsx-Sheet_3-MEG3-KD_Down-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DHX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16085
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NGP	DepMap CRISPR Gene Dependency	1.0	2.00185
BRD-K07794261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17854
BRD-K40306365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13308
GSE130676_0_v_2_suds3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Alendronate sodium trihydrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211976
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46115
496100318_PCx_probable Alzheimer's disease_TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.81926
NPTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22118
PMC9882185-media-2.xlsx-All_B2-AR_targets-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Hypoglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
MCF7_TG101209_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130815
PLXNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03764
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2625
GSE147056_4_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
GSE143643,GSE143644_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205021_3_v_2_fenofibrate_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Kenyon cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.519
GSE84462,GSE84762_0_v_1_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143643,GSE143644_3_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118766_1_v_0_ifng_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19175
GSE139325_0_v_3_cd36_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9753996-jci-132-160767-s182.xlsx-IRF4_assciated-ABCA7_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168797_1_v_6_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE237040_6_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MRPL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13439
BRD-K93752373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50256
DAGLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50436
GSE186483_6_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A71666580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66392
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1958
EMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08788
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.50302
Berbamine (dihydrochloride)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0253324
increased insulin sensitivity	MGI Mouse Phenotype Associations 2023	1.0	null
mRNA stabilization	GO Biological Process Annotations 2025	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.25339
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K98529522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33495
GSE217156_1_v_3_trpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185944_2_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211128_7_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14812927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03599
GSE254517_3_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE135514_8_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZFAND4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02481
EIF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18883
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.89105
PNRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2468
A549_Decitabine_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0127819
GSE203158_5_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TFE3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9642
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26638
BRD-K88282877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12474
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphoid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.156
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182680,GSE182683_0_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.75306
BRD-K27356753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0304
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112761,GSE112767_2_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE124097_3_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.484656
MCF7_Fasudil_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173412
MZT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22599
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HS695T	DepMap CRISPR Gene Dependency	1.0	3.86421
GSE89154_1_v_0_proscillaridin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169697,GSE169725_0_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77250455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04649
PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-FOSL2_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
TTC642	DepMap CRISPR Gene Dependency	1.0	5.05137
GSE114992,GSE114993_4_v_6_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12347309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0271
regulation of fat cell differentiation	GO Biological Process Annotations 2023	1.0	null
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.1903
BRD-K45272675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.101
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.21685
PMC4728380-ncomms10153-s8.xlsx-MYC_binding_intensity_Targets-Unnamed_9_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127790_5_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-ER_ZNF_GATA3-Gene_Name_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A44068497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56295
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.32725
GSE220668_0_v_1_ncapg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75252192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59486
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Def_End_D4_GATA6-dependent-ENSEMBL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K21568472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27128
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-Non-spreading_targets_gene_names_2497_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE87404,GSE87812_2_v_0_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152799
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chylomicron retention disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
BRD-K64424704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.098
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
response to molecule of bacterial origin	GO Biological Process Annotations 2023	1.0	null
BRD-K92378241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26346
GSE112760,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86285108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52744
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
GSE211128_7_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
RHOXF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4619
Lipid storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.848
PMC10709142-41556_2023_1281_MOESM2_ESM.xlsx-Supplementary_Table_1-CLUSTER_1_MAF_upregulated_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_13_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K79179851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30845
GSE102269_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Schwalie et al.Nature.P2_Adipose tissue_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Cyclocytidine HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136144
GSE128333_4_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12047497-mmc5.xlsx-Sheet1-GSE20754_WT_VS_TCF1_KO_MEMORY_CD8_TCELL_UP_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K40876208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04615
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE229580_2_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE173262_6_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K93032100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20673
Delayed sleep phase syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.278
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.58755
BRD-K68118416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03595
EIF2B5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10048
GSE165071,GSE165072_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Metabolic dysfunction-associated steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.088
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_9_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142232,GSE142234_0_v_2_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9882185-media-2.xlsx-All_B2-AR_targets-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53643174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3593
BRD-K14533399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65428
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.55
Baicalin_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0258292
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210521
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5527282-ncomms16041-s3.xlsx-M_LPS_-_gene_signature-Supplementary_Data_2_Full_gene_list_of_M_LPS_-_signatures_as_defined_in_figure_3_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE246716_0_v_1_trappc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Roxadustat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156229
PMC3712200-584604.f1.pdf-28-GRHL1_GRHL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158320,GSE183351_0_v_3_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE195568_1_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100917
GSE111035,GSE111040_8_v_5_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE192663_1_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7595190-41598_2020_75453_MOESM6_ESM.xlsx-MLL_EFS_groups_DEGs-Symbol_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159209
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125918
CERS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60227
Plastid large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.298
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292705
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4909
BRD-K26748243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01843
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me2_RS411_n_603_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01438
PMC6080909-JEM_20171312_TableS1.xlsx-Each_THP1_Pulldown_Expt_Targets-Unnamed_5_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10176883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97481
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NB1	DepMap CRISPR Gene Dependency	1.0	2.52831
BRD-K26122955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53587
Small intestine epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.55
PMC3607232-mmc1.xls-MLLN_AF4_H3K79me2_RS411-MLL_AF4_H3K79me2_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Noc complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.942
PMC11237033-41419_2024_6873_MOESM3_ESM.xls-Supplementary_Appendix_2-FOSL2_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
ERVV-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1042
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.8942
BRD-K18768614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16712
BRD-K99581286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11445
BRD-K96023136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74567
CRCGN017_MCF10A.WT.HP_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5201
PPP1R15A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41337
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1208
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193900,GSE193905_1_v_0_pura_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175920_0_v_1_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE251992_1_v_0_saracatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE226091,GSE226092_3_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K04067194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26528
Perinuclear region of cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE255680_1_v_0_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE109285_5_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149627
MCF7_Abexinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112074
CRCGN015_HEPG2_48H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13819
negative regulation of mRNA catabolic process	GO Biological Process Annotations 2025	1.0	null
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K73443280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68284
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221576
BRD-K67458784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65918
MM160113	DepMap CRISPR Gene Dependency	1.0	2.56167
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4356
UTP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31829
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
GSE217452_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE236003_2_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278915
BRD-K09732051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24189
GSE142210_9_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE186483_1_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157296,GSE157298_4_v_5_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83846772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12604
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.17
GSE89018_6_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K52123365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14521
BRD-K58614056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76733
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7506
GSE189683_3_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE162739_6_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0191176
VSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9778
GSE171837_3_v_1_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12623973-41467_2025_64981_MOESM3_ESM.xlsx-downregulated-c0_ACKR4_SCS_ceiling_LEC_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE149760_3_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial mRNA editing complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.038
GSE199660_1_v_3_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K62504352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30344
GSE201042_2_v_1_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_11_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NEMF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9128
GSE87404,GSE87812_2_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76353834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22367
MCF7_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182783
GSE148066,GSE157787_8_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE188458_2_v_1_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95685_2_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K40189164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42591
BRD-K26620362	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43985
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.959
BRD-M34385771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10862
T-cell acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.387
BRD-K00048792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.172
GSE137144_4_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149010_0_v_4_dars2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Exoribonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.412
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_G_gallus_1347_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
SLITRK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18629
GSE120415,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225083_0_v_1_kras_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acifran	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
TSHZ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23529
GSE118766_2_v_3_ifng_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_19_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
RNA stabilization	GO Biological Process Annotations 2023	1.0	null
BRD-K89338336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99256
GSE224969,GSE224971_3_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75220555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68082
poly(A)-specific ribonuclease activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K12918607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48446
GSE112761,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
Cry-Per complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.038
Bacteroid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.863
CHCHD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77288
GSE216394_2_v_0_pfkp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RC3H2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50535
BRD-K90049800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28414
MCF7_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00928366
BRD-K86838462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.81967
JURLMK1	DepMap CRISPR Gene Dependency	1.0	2.39097
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242647_2_v_0_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224556,GSE224557_8_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Homoharringtonine_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0373586
PMC7833686-mmc5.xlsx-e_q1en30_v1-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147943_0_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CAF-1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.242
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0234
BRD-A57474391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33744
GSE148066,GSE157787_5_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HT55_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.09465
Anethole trithione_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00762785
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.8264
GSE100863,GSE100864_3_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7781436-NIHMS1653552-supplement-Table_S2.xlsx-Variably_expressed_TFs-ZNF878_ZNF878	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K82504878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36159
GSE235066_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleus preopticus periventricularis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.241
BRD-K56431031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51379
GSE199660_1_v_0_secretin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CAKI2	DepMap CRISPR Gene Dependency	1.0	3.11518
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE132948,GSE132949_4_v_1_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56123
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GSE160246_9_v_1_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139799
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5794
BRD-K92949288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48716
GSE102870_7_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
496100339_HIP_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07612
BRD-K18077898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07108
GSE101546_3_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K03479638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58005
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7314
PMC7388612-vdaa078_suppl_supplementary_table_6.xlsx-MRs_PN_Rim-vs-MRs_PN_C-MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02793474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03396
Mo-T cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.956
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.53308
GSE96641_5_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-E2F1_UP_V1_UP-Ensemble_gene_ID_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
SUM185PE	DepMap CRISPR Gene Dependency	1.0	4.12808
GSE174586_0_v_1_slc4a11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIRPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79693
Dcp1-Dcp2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.224
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Salicylic acid_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0244174
BRD-A37523642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04241
palbociclib_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00893231
MCF7_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110676
BRD-K07781811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39835
Darolutamide_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00910815
GSE112762,GSE112767_2_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.049
GSE199255,GSE199356_6_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleus	GO Cellular Component Annotations 2023	1.0	null
BRD-K33689641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48056
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE175920_0_v_3_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RMDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41884
BRD-K63061929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47319
BRD-K86946907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0472
e1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.786
MORCPR	DepMap CRISPR Gene Dependency	1.0	3.37896
GSE229973_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE253795_1_v_0_alkbh5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25423143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24718
K562_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151379
AC-43-ZC52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259949
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11109217-41420_2024_2017_MOESM3_ESM.xlsx-Fig_4H_TAF2-bound_genes-Tag_dentsity_of_TBP_ChIP-seq_signal_for_TAF2-bound_genes_in_Fig_4H_TBP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112962,GSE112963_2_v_1_ddx5_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE254517_2_v_0_irf7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NPAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35045
GSE196540,GSE196542_2_v_0_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166315_1_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SNU46	DepMap CRISPR Gene Dependency	1.0	2.16592
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.423046
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FKBP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19259
MAPK14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13165
BRD-K38946705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7582
Posterior periventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.476
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Pracinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101597
PMC11781671-ppat.1012897.s015.xlsx-Tab_S1-S1_Table_The_detailed_information_of_DEGs_in_Huh7_cells_post_MSX1_overexpression_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K00191683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76985
BRD-K66327237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20095
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
BRD-A20305532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60548
regulation of mRNA stability	GO Biological Process Annotations 2025	1.0	null
SCS214	DepMap CRISPR Gene Dependency	1.0	3.14718
BRD-K10684867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22343
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K46348476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41871
MCF7_MLN8054_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146546
HT144	DepMap CRISPR Gene Dependency	1.0	2.72395
A549_PJ34_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015606
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K43719900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0404
Cement gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.875
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hepa-1c1c7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.709
PMC6844187-Table_15.xlsx-deg-S15_Table_Genes_that_exhibited_significant_differences_between_goats_and_sheep_FDR_10_Log2FC_2_in_response_to_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8818
A549_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170182
BRD-K85909950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20789
GSE179031_3_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158743_1_v_2_nfkbia_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Demeclocycline_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0122035
BT20_BREAST	CCLE Cell Line Proteomics	1.0	2.75378
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE136627_7_v_1_hdac4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06790927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46484
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.37562
GSE196699_2_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K83952475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12172
HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE228181_3_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of gene expression	GO Biological Process Annotations 2025	1.0	null
BRD-K52468958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0696
GSE182179_2_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Right colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.831
BRD-K91094364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20211
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6347712-pnas.1812449116.sd06.xlsx-iPSC_IRF7_48h_rest_RNAExpress-Gene_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6038
GSE242199_6_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
MDAMB453_BREAST	CCLE Cell Line Proteomics	1.0	4.57764
ARL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46978
BRD-K40117723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38081
GSE148066,GSE157787_0_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K13085116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99058
GSE196318_0_v_1_xpo4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K23029982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83185
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
decreased susceptibility to hepatic steatosis	MGI Mouse Phenotype Associations 2023	1.0	null
FOSL1-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.792
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67335
PMC2694838-1471-2164-10-241-S2.xls-Sheet1-Regulated_genes_by_ZNF191_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112761,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7778
GSE196699_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131887_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K21841771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41472
nucleus	GO Cellular Component Annotations 2025	1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7655
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
GSE153189_2_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Suprachiasmatic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.231
UFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79018
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.8597
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	1.0	null
HTR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.495
PRR14L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42489
positive regulation of fat cell differentiation	GO Biological Process Annotations 2023	1.0	null
GSE220914_2_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
PTPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11312
Hydroxyurea_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.021685
GSE202434,GSE202438_3_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_prom_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
mRNA binding	GO Molecular Function Annotations 2025	1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6079
GSE70499_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.536
NVP-BHG712_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0221126
MCF7_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192463
GSE135514_2_v_0_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.27035
XBP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9905
496100328_TCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13117
EM2	DepMap CRISPR Gene Dependency	1.0	4.299
BRD-K81463178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18283
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.952
RNA exonuclease activity, producing 5'-phosphomonoesters	GO Molecular Function Annotations 2023	1.0	null
KE-73-XV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243422
BRD-A68865339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25626
MCF7_Tubastatin A HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140501
GSE182179_5_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-Downstream_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K26976202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31189
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148252_2_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K05269173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49337
MCF7_Navitoclax_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169715
PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
TYKNU_OVARY	CCLE Cell Line Proteomics	1.0	2.06264
Adult stem cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.148
BRD-K62983405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2183
BRD-K98161915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56463
Chronotype	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.9
Circadian Clock	Reactome Pathways 2024	1.0	null
IBMX	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.63062
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
A673	DepMap CRISPR Gene Dependency	1.0	2.06558
Circadian rhythm genes	WikiPathways Pathways 2024	1.0	null
GSE198165,GSE198166_5_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131887_1_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Homoharringtonine_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0327356
RUNX2-24655370-MC3T3E1-MOUSE-BONE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K23547378	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72193
GSE81803,GSE81912_3_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178695
BRD-K06344882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48582
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.676
BRD-K20185935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11465
Attention deficit hyperactivity disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.579
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.603
GSE243683_0_v_1_s100a16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12164972-FSB2-39-e70689-s001.pdf-47-TEAD1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06935782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13643
Cells - Cultured fibroblasts	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.747454
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
plastid-encoded plastid RNA polymerase complex A	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.75
Esophagus - Muscularis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.873876
GSE224877_3_v_0_pctp_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nicotinamide nucleotide metabolic process	GO Biological Process Annotations 2025	1.0	null
BRD-K68665079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33451
GSE150548_1_v_0_rbmx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226114,GSE226116_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
COGN278	DepMap CRISPR Gene Dependency	1.0	3.73682
Dexamethasone_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0222901
ERAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01338
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0
GSE201309_5_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE93309_5_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
purine nucleotide metabolic process	GO Biological Process Annotations 2025	1.0	null
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_downregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
SMSCTR	DepMap CRISPR Gene Dependency	1.0	3.6201
NCIH647_LUNG	CCLE Cell Line Proteomics	1.0	2.07883
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of mRNA catabolic process	GO Biological Process Annotations 2023	1.0	null
GSE125007,GSE125008_6_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110268_0_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226115,GSE226116_1_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189193
Vagina	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.6716
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171311_0_v_1_ellagic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
P granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.649
496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.01982
GSE142210_11_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K89801935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42794
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120370_4_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH446	DepMap CRISPR Gene Dependency	1.0	6.89644
negative regulation of osteoblast differentiation	GO Biological Process Annotations 2025	1.0	null
C1orf131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2593
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	1.0	null
RNA exonuclease activity, producing 5'-phosphomonoesters	GO Molecular Function Annotations 2025	1.0	null
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE84922,GSE84924_4_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of gene expression	GO Biological Process Annotations 2025	1.0	null
BRD-K50704115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42551
GSE202134_0_v_1_rbm39_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21759602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49652
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-BrtoFay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237040_4_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A_48H:M22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37726
PMC11059513-mmc1.xlsx-Supplementary_Table1-Table_S1_The_gene_profile_was_down-regulated_after_HIF1A_was_knocked_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28140029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41242
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135352_0_v_1_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE148066,GSE157787_8_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36852613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45898
GSE217873_1_v_2_nusap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TMEM191B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20308
BRD-K93737936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14485
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140441_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6137307-mmc2.xlsx-IRF9-IFNa-Table_S1_IRF9-IFNa_Related_to_Figure_1_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25485483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45774
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27638063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23394
H2BC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29119
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274099
regulation of osteoblast differentiation	GO Biological Process Annotations 2025	1.0	null
GSE121198,GSE129779_0_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE237040_0_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE246660_1_v_0_lmo3_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXQ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21481
MCF7_Givinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0087759
PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34537
transcription by RNA polymerase II	GO Biological Process Annotations 2025	1.0	null
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.7669
PMC11333005-ppat.1012426.s020.xlsx-ISGs_IFNb_up_IRF9-indep_3dpt-ENSEMBL_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
DCTN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.84371
NGLY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07972
GSE116354,GSE117379_3_v_4_cox2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K40474424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46904
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.287
GSE71491_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PAN complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.799
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
T-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.107
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-MYC_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PH-797804_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0129757
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K56354139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07931
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K25718630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.75807
CCT128930	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.93
SMAD5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0792
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4117
GSE154577_6_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.27804
t55-gastrocnemius_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	8.15187
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3134
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.948
U6 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.565
Mitotic spindle pole body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.54
MCF7_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123328
BRD-K99125195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19667
GSE206870,GSE206872_4_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CINP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18709
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TFEB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8605
BRD-K63984483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28894
chp126	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.292
BRD-K98772859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10096
CAMKK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20713
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.621031
PMC8185471-mmc4.xlsx-D2-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_2_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73523821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76064
L-Eflornithine (monohydrochloride)_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.010733
TE1_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.90591
GSE182854_2_v_0_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120413,GSE120447_3_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K09777330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45064
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.37886
A549_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197489
BRD-K46313713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.08459
JUND-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
transcription by RNA polymerase II	GO Biological Process Annotations 2023	1.0	null
BRD-K80198069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68549
BRD-K83475223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05766
GSE128232,GSE128233_1_v_0_phf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18000429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01879
GSE195568_3_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216540_0_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.578924
GSE137144_5_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.77772
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67142640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24338
BRD-K16376056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65419
Blastopore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.645
BRD-K87901124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32807
GSE175920_0_v_2_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K43922968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76713
GSE110178_2_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102675_3_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RNA binding	GO Molecular Function Annotations 2023	1.0	null
GSE242199_9_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.041
BRD-K91596921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00151
BRD-K40809590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38919
PMC10243915-uxad037_suppl_supplementary_table_s1b-table_s3b.pdf-186-ZNF671_ZNF671	Rummagene Transcription Factor Associations 2026	1.0	null
WM115	DepMap CRISPR Gene Dependency	1.0	3.51136
GSE131887_5_v_4_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K39420925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1741
Norepinephrine (hydrochloride)_NCI-H2122	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0253288
BRD-K49473928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06114
BRD-K86986995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03299
BRD-K60389305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14333
GSE196699_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K87743988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25824
MSANTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17405
BRD-K90956468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34964
GSE218727_2_v_3_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE143830_0_v_1_trex1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:G08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00355
GSE198165,GSE198166_9_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.846
GSE210655_1_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05584347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.52469
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PFN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01334
GSE93309_5_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR2_targets-genes_ESR2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188401
LACTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08686
COA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05618
ZNF35	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5952
A549_M344_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113405
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_1hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K46121327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39908
GSE240896,GSE240899_10_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tazarotene_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00596596
CRCGN017_MCF10A.TP53.M_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1015
BRD-K75380271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38392
BRD-K57014223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64085
GSE195663_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169713,GSE169715_1_v_2_tert_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169571_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159893_2_v_1_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K04968881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2904
PMC10684125-cm9-136-2712-s001.xlsx-Sheet1-FOSL2_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN009_HEPG2_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6146
BRD-K10146653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29122
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101546_3_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BHLHE41	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6955
BRD4-28847988-BCBL1-HUMAN-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
3'-5' exonuclease activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K05074020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01882
GSE119978,GSE180930_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE185519_1_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176161
impaired glucose tolerance	MGI Mouse Phenotype Associations 2023	1.0	null
Lung	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.705313
NPFF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41564
3'-5'-RNA exonuclease activity	GO Molecular Function Annotations 2025	1.0	null
GSE71529,GSE71558_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K11643336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72143
GSE148066,GSE157787_8_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186252
Polysome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.344
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.1674
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205163,GSE205164_5_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9580020-tx2c00131_si_004.xlsx-Fig_5B_data-TABLE_S3_CORE_GENE_TARGETS_HSF1_KOVACS_ET_AL_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184884_2_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Encysting cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.551
GATA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5343
PSORS1C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32054
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_CUDC-101_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0115015
Ribulose bisphosphate carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.801
GSE158834_7_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE236003_1_v_3_ubr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.812
fh8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.655
BRD-K77845452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.82339
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.455448
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K49303291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1682
GSE153341_2_v_0_atf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Molting gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
MCF7_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0144896
A549_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124245
RITS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.818
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE181517_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220668
RACK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.92807
PMC10794847-mmc5.xlsx-PIAS1_KD_up-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
GSE175920_4_v_1_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE100102_2_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50345393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38647
BRD-A90450579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37355
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
Homoharringtonine_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0234021
TPRKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83407
GSE58724_3_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_Jurkat_LPS_vs_DC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.266
Cysteamine (hydrochloride)_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0182862
GSE152441,GSE152442_7_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pupa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.085
PCYT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7258
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC2694838-1471-2164-10-241-S3.xls-Sheet1-Commonly_altered_genes_by_ZNF191_overexpression_and_knockdown_ZNF24	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225762_1_v_0_pcmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE240896,GSE240899_2_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH28	DepMap CRISPR Gene Dependency	1.0	2.03663
CRCGN017_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1143
MCF7_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138384
Hairy cell leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.839
SAM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.567
Clopidogrel_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0128258
PMC9792572-main.nxml--Proteins_Bound_to_GLIS2_GLIS2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE70499_5_v_6_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12175788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64979
BRD-K13206026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18882
positive regulation of cell differentiation	GO Biological Process Annotations 2023	1.0	null
BRD-K88418404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25174
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_12hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Supplementary_Table_4B_DEGs_in_ATF4-def_cells_comparing_Tg_2h_to_its_DMSO_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE173997_3_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE232631_0_v_3_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE247764_3_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197948_2_v_1_atp7b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKMEL2_SKIN	CCLE Cell Line Proteomics	1.0	2.30401
GSE235066_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHMP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27047
GW body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.909
CRCGN017_MCF10A.WT.HP_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8457
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150349_0_v_1_msx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K20024170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64177
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K12035825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13872
GSE111247_14_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K54686062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37376
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.70731
Sleep disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.368
BRD-K22608982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42857
ESCO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0106
TC32	DepMap CRISPR Gene Dependency	1.0	2.16785
MCF7_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159203
PMC5263239-mmc2.xls-SEM_-_MLL-AF4-All_targets_genes_names_2597_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A11130173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29221
GSE100863,GSE100864_2_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242167_1_v_2_cd40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K82107433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07142
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE191022,GSE191031_0_v_1_igf2bp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224294_4_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K35724671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3117
GSE193258,GSE193259_2_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K17176016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46985
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8523
GSE142210_4_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Seasonal affective disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
COGN305	DepMap CRISPR Gene Dependency	1.0	2.76301
SCHNEIDER-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.304
MCF7_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01164
GSE213228_4_v_3_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K02392990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11692
Abdominal adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.255
mt2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.917
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_0_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	5.5871
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268785
CRCGN016_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.62072
GSE137914_0_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.545
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136388
BRD-K72709319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17103
GSE211931_0_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1145
BRD-K18409585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05276
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K84879982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38243
MCF7_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241314
BRD-K67137502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1944
GSE252857_2_v_3_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
methylcrotonoyl-CoA carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
SKMEL3_SKIN	CCLE Cell Line Proteomics	1.0	3.07273
A549_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121707
GSE231648_1_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FD-59-TC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223118
3'-5' exonuclease activity	GO Molecular Function Annotations 2025	1.0	null
GSE157594_6_v_2_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K22907310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27008
GSE231799_2_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
MIS18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70966
BRD-K26200833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03322
GSE167373_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE223008_9_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE151689_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169155_3_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.87995
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.841
BRD-K73275682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53691
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EXOC3L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49826
BRD-K68492420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64015
PMC4082627-12864_2014_6197_MOESM8_ESM.xlsx-ER_ZNF_GATA3-Nearest_Ensembl_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3485261-pone.0046600.s008.docx-0-JAZAG_TGFB1__SIGNALING_VIA__SMAD4_UP_SMAD4	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB33	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7957
496100654_HIP_no dementia_no TBI_86_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.49844
increased circulating glucose level	MGI Mouse Phenotype Associations 2023	1.0	null
SNU1544	DepMap CRISPR Gene Dependency	1.0	2.06914
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH3122	DepMap CRISPR Gene Dependency	1.0	4.32159
GSE223241_2_v_0_cdkn2a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148066,GSE157787_5_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214596,GSE214598_1_v_4_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K31059159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41996
GSE147876,GSE147877_2_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE217694_3_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8202205-NIHMS1706275-supplement-Table_S1.xlsx-Mesend_D2_GATA6-dependent-SYMBOL_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K66734120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26644
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.335893
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348939
A4GALT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00951
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
response to molecule of bacterial origin	GO Biological Process Annotations 2025	1.0	null
GSE149075_3_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3L_Peaks_2SA-YAP1_TEAD4-Unnamed_11_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5263239-mmc2.xls-SEM_siMLL-AF4-MLL-AF4_gene_targets_with_decrease_in_MLL-AF4_ChIP-seq_signal_2198_unique_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218171_1_v_0_foxn3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE134214_0_v_1_ell2_human	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013886
BRD-K36376229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07805
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K73587666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14072
MAFG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.291
A549_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137542
Artery - Coronary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.6716
Adrenal Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.730597
BRD-A17120244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.5063
BRD-K18332967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40054
MCF7_TAK-901_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186495
BRD-K05868476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33035
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83513
PMC11221067-JCMM-28-e18520-s002.xlsx-Supplementary_Table_2-FOSL2_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12549544-mmc2.xlsx-AA_D28_VS_D42-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
TMEM160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05105
HES1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4162
PITX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.447
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DDR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45056
A549_Regorafenib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153624
GSE214596,GSE214598_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CALD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01534
TUHR14TKB	DepMap CRISPR Gene Dependency	1.0	2.29095
CRCGN010_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.82416
BRD-A80705936	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50001
BRD-K29120026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1594
Asciminib_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00517541
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27531
GSE220520_1_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PIGA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02764
positive regulation of fat cell differentiation	GO Biological Process Annotations 2025	1.0	null
TTC709	DepMap CRISPR Gene Dependency	1.0	2.53972
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
GSE128730_4_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K58077750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0352
GSE153341_2_v_3_atf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61423234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44209
BRD-K95033255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10365
NCIH2122	DepMap CRISPR Gene Dependency	1.0	4.44899
GSE155305_3_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
T-cell non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.393
phosphatase activity	GO Molecular Function Annotations 2025	1.0	null
PMC11836325-41467_2025_56634_MOESM8_ESM.xlsx-gene_table_NGS5844-Supplementary_Data_6_Gene_targets_lost_in_resistant_cells_upon_FOSL1_knockdown_and_their_corresponding_hallmark_pathway_FOSL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176305_0_v_1_rotenone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Acute leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
BRD-K30288714	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.78365
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE188870,GSE188871_0_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.291509
MCF7_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204888
GSE77108_5_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K40016301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69141
Ring gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.229
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Rosiglitazone_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00774863
PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3A-Down_Dpy30_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62692910	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17109
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE104604_1_v_0_eif5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PAX7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97143
CRCGN008_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0161
DDX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15442
NT5DC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79873
Docetaxel (Trihydrate)_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0142638
BRD-K54862370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33894
Valdecoxib_NCI-H661	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0166961
GSE168797_2_v_3_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6364
PMC9580020-tx2c00131_si_003.xlsx-Fig_5A_data-HSF1_KOVAC_same_dataset_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE157777_2_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CEM-VBL100 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.647
BRD-K98374711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06564
Translation repressor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.72
Outer mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.304
GSE158834_7_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE224969,GSE224971_3_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ovarian steroidogenic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.623
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.08389
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Miz_KD_up_Myc_KD_down_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05098996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18758
Lipid metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
BRD-K47636083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02077
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3585
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7624
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE156454_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.057
BRD-K24514314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56863
CRCGN011_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.80235
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137144_3_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_S-Ruxolitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155165
GSE148321,GSE169423_0_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158182_3_v_0_pnpla3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Tazemetostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206278
PMC6137307-mmc2.xlsx-STAT2-IFNa-Table_S1_STAT2-IFNa_Related_to_Figures_1_4_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE150134_1_v_0_scn5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE87412,GSE92423_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K06117861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44522
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
phosphatase activity	GO Molecular Function Annotations 2023	1.0	null
XRCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43446
BRD-K10862230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59235
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.632
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K87930002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25133
BRD-K32343246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07731
GSE139987_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215086_0_v_1_batf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100534
PMC7397849-supp_gad.338681.120_Supplemental_Table_S1.xlsx-S1L_Shared_genes_3way_overlap-Suppl_Table_S1L_Shared_genes_between_YAP1-MAMLD1_YAP1-FAM118B_YAP1-TFE3_in_vitro_human_samples_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.40525
GSE148066,GSE157787_3_v_10_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DMS273_LUNG	CCLE Cell Line Proteomics	1.0	3.19802
CRCGN013_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76875
NFKB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.7057
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NADP metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE210770_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE245778_1_v_0_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164757,GSE164759_4_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE136742,GSE136744_2_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60729
PRRT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2839
GSE152699,GSE152723_3_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6299095-41389_2018_108_MOESM4_ESM.xlsx-T47D-TRPS1_peak-gene_symbol_TRPS1	Rummagene Transcription Factor Associations 2026	1.0	null
poly(A)-specific ribonuclease activity	GO Molecular Function Annotations 2025	1.0	null
PDX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11784
496100586_HIP_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	4.86318
Ovary	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.654744
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76755209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1063
BRD-K85234739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18661
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185276
negative regulation of cell differentiation	GO Biological Process Annotations 2023	1.0	null
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112762,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Peripheral T-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
BRD-K20987582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96424
BRD-K05304510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03671
PMC8755441-mmc3.xlsx-IRF7-Up-stat1-hela_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28057105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46499
Hexylresorcinol_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0161463
BRD-K46001734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07342
SNU216	DepMap CRISPR Gene Dependency	1.0	5.22864
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35569
LCLC97TM1	DepMap CRISPR Gene Dependency	1.0	3.16523
BRD-K96567801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06438
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.43
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207514,GSE207515_1_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nucleoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K19702946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.498
Tucidinostat_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00697984
B3GNT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31882
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.77531
GSE164757,GSE164759_1_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.051
BRD-K06116445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12273
PCGF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99894
MCF7_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126956
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2906
GSE185163_5_v_1_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hydroxytoluic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86175
BRD-K40738002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05216
Homoharringtonine_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0157342
GSE146074_1_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chr4_138931442_T_C_b38	GTEx eQTL 2025	1.0	1.36233
Homoharringtonine_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0414151
GSE168401_1_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
C6orf62	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16341
Heart - Atrial Appendage	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.726383
3-methylcrotonyl-CoA carboxylase complex, mitochondrial	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.681
ECC4	DepMap CRISPR Gene Dependency	1.0	4.80847
BRD-K19925255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28237
GSE202434,GSE202438_6_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-421_ChIP-Seq_H3K9me1_2_AR_differential_expression_upon_KDM3A_or_AR_knockdown_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234595
CRCGN014_HEPG2_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08892
PGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56196
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K13888422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07665
GSE228181_4_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BI-78D3_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0323167
BRD-K59191599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79844
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K83690550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00513
Inflammatory bowel disease 25	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
BRD-K55220938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68017
membrane-enclosed lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE174498,GSE174500_3_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
Response to ziprazidone in schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
BRD-K46155894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74129
GSE131649_4_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PADI4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32744
MCF7_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149627
PMC8724844-bt-30-1-98-supple2.xlsx-Hallmark_pathways-FOSL2_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67998155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99769
Pronephric tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.886
GSE142210_3_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Corpus allatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.4
GSE160373_6_v_2_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3607232-mmc1.xls-RS411_SEM_common_AF4_MLLN_K79Me-MLL_AF4_H3K79me3_SEM_n_2490_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47804666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07002
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4699
GSE234340_3_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184884_7_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE252857_2_v_3_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61247793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81742
BRD-K68086276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12066
GSE156033_1_v_2_sparc_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K44260904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27822
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-gene_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100536_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.85635
GSE248883_0_v_1_shmt2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DA-20-VR86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.376426
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4739
SKLU1_LUNG	CCLE Cell Line Proteomics	1.0	9.34334
BRD-K30296979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29316
POLR2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05614
SPIRE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51827
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.367
GSE228413_0_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TMSB10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5366
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FAM193B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70863
PMC4029819-pone.0098069.s004.xlsx-SAM_FOXA1_h_vs_FOXA1_l-Table_S3_SAM_analysis_of_FOXA1_high_versus_FOXA1_low_cases_FDR_0_01_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K33956247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45071
GSE147943_2_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K90887068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02923
SHH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97636
LIVF001-028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55756
EN	DepMap CRISPR Gene Dependency	1.0	2.24223
BRD-K16643911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01366
A549_Hesperadin_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121481
LHX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6262
GSE96641_5_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K65887908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14126
CIAPIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27611
BRD-K90205159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63824
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230963
GSE87404,GSE87812_1_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86371068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67055
BRD-K93980445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18969
GSE153258_1_v_0_dcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE98755,GSE98756_3_v_0_fbxl19_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24366
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119564_1_v_3_zfp217_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Berbamine_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.036305
A549_UNC0379_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011968
GSE173997_1_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3'-5'-RNA exonuclease activity	GO Molecular Function Annotations 2023	1.0	null
BRD-A99445203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80533
GSE213588_10_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75136523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43322
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1542
PSS008	DepMap CRISPR Gene Dependency	1.0	3.24613
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.223
TIGD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32105
HEC265_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	4.18224
GSE111061_1_v_0_tofacitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
BRD-K40001470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21704
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.809
GSE149010_0_v_6_dars2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K19046167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02363
BRD-K85235446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23896
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27083306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22164
PMC9038526-mmc1.xlsx-postCOVID_LPS_vs_healthy_L-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K55399138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3121
GSE193588_1_v_0_pax3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3657
BRD-K67670670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07482
BRD-K38431962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.70489
PMC7808269__F5	PFOCR Pathway Figure Associations 2024	1.0	null
Epididymal white adipose tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.001
BRD-K77465015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.347
GSE101546_3_v_1_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PLEKHG4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09713
MCF7_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149872
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226770_1_v_6_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142588
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.497
Sildenafil_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0320762
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.236
EFNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45684
RAD54B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26078
MCF7_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133306
A549_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014056
GSE137653_4_v_0_siglecf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE237426_0_v_1_eif4a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE115363_1_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K08006576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14997
Sleep disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.959
BRD-K13752834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36927
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5666
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K34447537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27068
GSE110268_2_v_3_foxd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SKNEP1	DepMap CRISPR Gene Dependency	1.0	3.49964
MCF7_MK-5108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0137826
Translation initiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.771
BRD-K00265832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.55459
BRD-K78088874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26548
BRD-K41396351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53459
BRD-K92176613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30774
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.424909
GSE186654_0_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157296,GSE157298_4_v_2_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Oligoasthenoteratozoospermia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.021
GSE205316,GSE205317_2_v_3_nrip1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE145476_2_v_0_hopx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146109
BRD-K05154886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31223
BRD-A30758703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9577
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014406
GSE201042_6_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_down-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NADP phosphatase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K08576275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00404
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OTX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9777
GSE173262_2_v_0_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-KLF4_Targets_Enrichment-Unnamed_12_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K32406588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13164
GSE179031_0_v_2_foxp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7179
BRD-K61681480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55898
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4257
regulation of fat cell differentiation	GO Biological Process Annotations 2025	1.0	null
Internal iliac artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.897
CRCGN015_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31573
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Eating disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Plant tumor tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.969
GSE81193_0_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111247_2_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8725436-12864_2021_8226_MOESM3_ESM.xlsx-Sheet1-Table_S3_Target_molecules_of_NFE2L2_and_their_directional_changes_in_the_RNAseq_dataset_from_fasted_vs_12hrpf_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0085452
NB4	DepMap CRISPR Gene Dependency	1.0	5.41224
GSE138938_1_v_4_foxp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:C14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38805
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236504,GSE236505_0_v_1_atmin_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2648
BRD-K45813167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45755
Pancreas	GTEx Tissue Gene Expression Profiles 2023	1.0	3.93018
GSE111247_0_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7808269__F5	PFOCR Pathway Figure Associations 2023	1.0	null
LNZTA3WT4	DepMap CRISPR Gene Dependency	1.0	2.72565
BRD-K50177531	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57547
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FDR_0_1_RELB_RNAi-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
NADP phosphatase activity	GO Molecular Function Annotations 2025	1.0	null
Preadipocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.536
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Disease of mental health	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.959
PMC11426526-ppat.1012555.s011.xlsx-DEG_MDDC_Jurkat_LPS_vs_MDDC_JK-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K59149254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88121
ALPG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49924
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Crown gall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.366
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120358
MCF7_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216469
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.248915
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232314
AKAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73967
GSE233679_5_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.5992
PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12696503-mmc2.xlsx-ST15_KD_RNA-seq_diff_expr-ensembl_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198165,GSE198166_0_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.69472
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PSME2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07722
BRD-K02630367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07239
K562_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153749
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185944_0_v_1_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132929
A549_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.016304
A549_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014698
GSE131649_6_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.747239
GSE228181_0_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.98445
GSE197532,GSE197533_0_v_1_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
VAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0076
CRCGN015_HEPG2_48H:G20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5075
Adult T-cell leukemia/lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.518
TRIM28-17542650-NTERA2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE148066,GSE157787_3_v_6_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.320236
Lopinavir_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0258378
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4552674-pone.0136569.s005.xlsx-Blad1-DOWNSTREAM_MOLECULES_OF_NFE2L2_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE137144_4_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K39526528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74554
GSE247764_0_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Epithalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.33
Pineal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.351
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83564
A549_PFI-1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135249
BRD-K75440064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1964
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135311
BRD-K11506071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10945
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE186471_1_v_0_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12205070-41467_2025_61222_MOESM5_ESM.xlsx-DE_markers_TAL1_scenic_reductio-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4728380-ncomms10153-s6.xlsx-Pre-ranked_gene_list_MYC_Target-Supplementary_Data_5_GSEA_analysis_of_c-MYC-bound_promoters_in_control_HFF_MYC-ER_cells_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
496100412_FWM_possible Alzheimer's disease_TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.17821
Raltitrexed_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0298362
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5997
PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K63212062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03489
PMC9564215-pnas.2203480119.sd02.xlsx-OVCAR-5_SCD_KD_cultured_in_low-hgnc_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Abemaciclib_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0129869
BRD-K31110422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38485
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Specific developmental disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.579
GSE206870,GSE206872_4_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TC138	DepMap CRISPR Gene Dependency	1.0	5.73824
BRD-K29298614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02794
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE110178_5_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM4_ESM.xlsx-B_ATF4-def_Tg_2_vs_DMSO_2-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K29144516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00076
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112760,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.568
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018242
wc1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.177
Archenteron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.602
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.27985
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE101239_5_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE242199_2_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE128730_7_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE221327_1_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-LEUTX_DOWN-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_down_from_an_FPKM_of_at_least_2_LEUTX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74311661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47933
BRD-K73723329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13771
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR	Rummagene Transcription Factor Associations 2026	1.0	null
3T3-L1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.563
GSE157904_3_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7907
BRD-K26612358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77048
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171814
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A73965025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04069
GSE161842_1_v_2_kdm6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H1-7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01267
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.577
CRCGN008_HEPG2_24H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.27765
Oxaprozin_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00897861
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233007
GSE242199_2_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K59045095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12284
GSE160017,GSE160022_1_v_0_trem2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151119_3_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149901_3_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE179002_0_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122101,GSE122103_3_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K92806245	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02248
HCC2218_BREAST	CCLE Cell Line Proteomics	1.0	2.21855
CRCGN017_MCF10A.WT.HP_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09986
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82364958	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11755
MCF7_Dacinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00929263
GSE185635_0_v_1_ncor1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206270_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120370_0_v_3_thrombin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3C1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16006
UMUC16	DepMap CRISPR Gene Dependency	1.0	3.71286
Schwalie et al.Nature.G2_Adipose tissue_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
Dorsal hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.897
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274544
positive regulation of cell differentiation	GO Biological Process Annotations 2025	1.0	null
BRD-A55411938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24096
GSE179031_0_v_1_foxp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.626
GSE173405_3_v_0_dmba_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NADPH phosphatase activity	GO Molecular Function Annotations 2025	1.0	null
A549_AT9283_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119496
GSE107505_1_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
response to lipopolysaccharide	GO Biological Process Annotations 2023	1.0	null
GSE173911,GSE173917_0_v_1_morc3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE110178_2_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE81193_3_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186316_0_v_1_ccn2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152698
HSPA13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11819
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE48812_3_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Wt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	93.9273
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE63048_11_v_12_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158812
PMC6715699-41467_2019_11785_MOESM4_ESM.xlsx-CSL_KD-Genes_differentially_expressed_upon_CSL_silencing_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K29838935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3549
BRD-K76788397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66385
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140651
PMC3607232-mmc3.xlsx-a_RUNX1_SEM_MLLN_AF4C_H3K79Me-x_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
CME1	DepMap CRISPR Gene Dependency	1.0	3.23954
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A47109850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32965
SLC20A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15825
BRD-K67980271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06089
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-TFAP4_TFAP4	Rummagene Transcription Factor Associations 2026	1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.281868
ONDA9	DepMap CRISPR Gene Dependency	1.0	3.50862
GSE199606_1_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cajal body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.016
PMC8787225-Data_Sheet_1.xlsx-STable_2_DEG-Supplementary_Table_2_1150_up-_and_down-regulated_differential_expressed_genes_upon_GATA2_activation_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
SNUC5_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.00161
BRD-K37015376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74869
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.017139
GSE152699,GSE152723_3_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
nicotinamide nucleotide metabolic process	GO Biological Process Annotations 2023	1.0	null
KD	DepMap CRISPR Gene Dependency	1.0	2.17842
BRD-K37515001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06512
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.316076
MCF7_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023861
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.11712
PMC9386181-Table5.XLSX-BFT-Unnamed_1_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147613_1_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18541
BRD-K78323315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16339
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121338
GSE231799_3_v_5_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216757_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K25269762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04627
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.213481
Retrocerebral complex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.346
GSE211357_1_v_3_atg7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K87230984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12894
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.15323
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.16
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27109474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04631
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
BRD-K54484733	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31574
GSE137914_2_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.822
Dasatinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.7
GSE107505_3_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235142
GSE101546_2_v_4_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112760,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.3998
BRD-K74688087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07586
PMC11333005-ppat.1012426.s020.xlsx-ISGs_IFNb_up_IRF9-indep_8dpt-SYMBOL_IRF9	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_MK-5108_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218813
Hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.087
GSE207787_1_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.056
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_18_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Procyclic form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.614
GSE189609_1_v_0_hax1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0279799
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.566
GSE214161,GSE214233_0_v_2_zmym2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR-8383 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
BRD-K87343552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03864
CAKI2_KIDNEY	CCLE Cell Line Proteomics	1.0	4.11028
Photoreceptor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.559
GSE172295_4_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nymph	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.649
GSE193402_0_v_4_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bloodstream form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.689
MCF7_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0100135
BRD-K06507315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04131
BRD-K10776934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18997
GSE120413,GSE120447_4_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203485_1_v_0_sunitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE132948,GSE132949_0_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10886332__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE150215_1_v_0_etl4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE63048_11_v_5_morc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UBXN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17196
GSE81803,GSE81912_0_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
MCF7_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00728635
8505C_THYROID	CCLE Cell Line Proteomics	1.0	3.28627
PMC8191339-mmc1.xlsx-Table_S3_DE_genes-LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166315_2_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9733061-13059_2022_2800_MOESM5_ESM.xlsx-Table_S4-Table_S4_Genes_assigned_to_JUNB_binding_sites_Each_peak_was_assigned_to_the_nearest_TSS_JUNB	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166315_2_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE179775,GSE198264_0_v_2_ctcf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2025	1.0	null
GSE240258_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7468443-Data_Sheet_2.xlsx-DEG_2h_LPS-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
IMR32	DepMap CRISPR Gene Dependency	1.0	4.76889
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.35345
GSE111247_11_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE137144_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156181
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ocellus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
negative regulation of osteoblast differentiation	GO Biological Process Annotations 2023	1.0	null
decreased susceptibility to diet-induced obesity	MGI Mouse Phenotype Associations 2023	1.0	null
Mature T-cell and NK-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
Brush cell (Tuft cell)_Lung_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
NADPH phosphatase activity	GO Molecular Function Annotations 2023	1.0	null
GSE201042_2_v_3_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NOL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19088
CHEK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26882
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SKMEL28_SKIN	CCLE Cell Line Proteomics	1.0	3.50335
PRORP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05677
496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.95723
FR 180204	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
GSE200839,GSE233826_5_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PKIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14924
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.7929
GSE223540_0_v_3_anxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Zfp809	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.7171
BRD-K67177501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46825
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2675
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186483_2_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12881
GSE237040_2_v_1_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149666
GSE139239_2_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K00611112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49983
GSE245270_1_v_3_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0823
MM1S	DepMap CRISPR Gene Dependency	1.0	2.98881
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5083
Hepatopancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.829
BRD-K73540839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05452
KNS42	DepMap CRISPR Gene Dependency	1.0	2.08301
PMC3607232-mmc1.xls-MLLN_prom_RS411-MLL_body_RS411_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Homoharringtonine_SW 1271	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.027678
Daptomycin_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00808433
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-TPRX1_DOWN-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_down_from_an_FPKM_of_at_least_2_TPRX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7452054-mmc1.docx-28-FOXG1_FOXG1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K26233698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97416
GTEx Blood 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	10.7773
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
GSE171837_3_v_2_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE198165,GSE198166_0_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TF1	DepMap CRISPR Gene Dependency	1.0	2.21581
MCF7_AG-14361_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0210717
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-348-YY1_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
POU5F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10661
BRD-A17658676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04885
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
BRD-K30310008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09149
negative regulation of macromolecule metabolic process	GO Biological Process Annotations 2023	1.0	null
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAFG::NFE2L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1377
BRD-K20215591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56746
BRD-A13983189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25999
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Steatotic liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.885
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146687_2_v_5_eribulin_human	RummaGEO Drug Perturbation Signatures	1.0	null
furafylline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1322
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-435-RLF_RLF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145171_0_v_1_prox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133286,GSE133299_1_v_0_tepoxalin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.63205
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE164757,GSE164759_1_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Homoharringtonine_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0119344
BRD-A99990159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58509
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185163_5_v_2_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bursa copulatrix	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.571
PMC7397849-supp_gad.338681.120_Supplemental_Table_S3.xlsx-S3M_Peaks_YAP1MAMLD1_TEAD4-Unnamed_14_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8283158-mmc2.xlsx-TCF4_ChIP-symbol_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-ARGFX_UP-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_up_to_an_FPKM_of_at_least_2_ARGFX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE182179_0_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_3_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
ACA	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
BRD-K53774433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12712
BMAL1:CLOCK,NPAS2 activates circadian gene expression	Reactome Pathways 2024	1.0	null
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE161846,GSE161849_1_v_5_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67011787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94
POMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39897
C4orf3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08646
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Acetazolamide_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0141029
BRD-K97666659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31848
GSE200352_1_v_8_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
m15	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_3hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE179002_2_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213228_2_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126219_0_v_1_haloperidol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19026
GSE68628_1_v_0_abcc5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Captopril_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0219435
Imiquimod (maleate)_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.01151
PMC5792454-mmc2.xlsx-Table_S5-Table_S5_Genes_up_or_down_regulated_in_murine_Hoxa9_IRX3_leukemias_versus_Hoxa9_MTV_leukemias_Gene_Ontology_annotations_IRX3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07160586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.89114
GSE101239_4_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE184133,GSE184137_2_v_0_esrrb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22041
GSE150669_2_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Gynecophoral canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
PMC4821877-ncomms10846-s9.xlsx-THP1_Splice_events-Gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112760,GSE112767_4_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K80232129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85718
BRD-K64417176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43329
GSE155305_2_v_0_ifitm3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C99	DepMap CRISPR Gene Dependency	1.0	5.61572
RPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00291
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1137
BRD-K25200031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12997
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K50240676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98483
Adult T-cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.198
BRD-K02106348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03269
GSE48812_3_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218819_2_v_1_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TC205	DepMap CRISPR Gene Dependency	1.0	3.84236
GSE149075_6_v_5_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Corpus cardiacum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.187
BRD-K62372121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01129
GSE202603_1_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K10343715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2275
BRD-K48899005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01059
BRD-K60127720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27392
TFEC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6772
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.95565
Nuclear lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3526
GSE186460_0_v_2_baricitinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ACAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00488
PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4A-Down_Nanog_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Mitochondrion	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BRD-K24598235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05954
P-body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.387
GSE132948,GSE132949_0_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81642886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06565
BRD-K32240435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88605
regulation of osteoblast differentiation	GO Biological Process Annotations 2023	1.0	null
GSE226285_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.161
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135514_2_v_3_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CLOCK-BMAL transcription complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.767
BRD-K14268329	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5113
WM2664_SKIN	CCLE Cell Line Proteomics	1.0	2.22978
GSE89154_1_v_3_proscillaridin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Mitochondrial outer membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.378
lomofungin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05009
DNA-templated transcription	GO Biological Process Annotations 2023	1.0	null
GSE216273,GSE216292_0_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FAM199X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30035
MLL3/4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.572
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5732
TAK-901_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0148183
BRD-K37656403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09499
8-Hydroxyquinoline_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00621194
GSE233679_12_v_7_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A40022950	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.48767
negative regulation of cell differentiation	GO Biological Process Annotations 2025	1.0	null
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.8204
BRD-K88190816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29511
Enterocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.558
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205730,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SKIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43467
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-E2F1_UP_V1_UP-Gene_name_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.86175
A549_UNC1999_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130284
GSE229978_4_v_7_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nerve - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.739026
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE219274,GSE219276_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K84233319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03718
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130677
Mafb	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.1783
MCF7_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136208
GSE77108_0_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9922
CSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01652
TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	4.66399
Miracidium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.701
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174498,GSE174500_3_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.87257
FGD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43204
MLX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8075
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K01121723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36572
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-7954	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.59
CRCGN015_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1798
Quinidine (15% dihydroquinidine)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00416501
MCF7_AR-42_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0111518
PMC4165364-13059_2014_406_MOESM5_ESM.xls-Supp_Dataset_1-SUPPLEMENTARY_DATASET_1_AML3_AzaC_SigDiff_1147_Note_to_reviewers_-_view_these_files_as_xls_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110580_1_v_0_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chloroplast large ribosomal subunit	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.346
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235066_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.99654
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K58532728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79851
BRD-K64646189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22444
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.02
GSE113329,GSE113335_2_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE218378_1_v_0_pbx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163464
GSE175920_4_v_3_nmda_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4219345-1471-2121-14-52-S3.xlsx-BORIS_hNP1-Gene_Symbol_CTCFL	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF549	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05334
PMC9376070-41419_2022_5157_MOESM18_ESM.xlsx-Sheet1-Table_S4_Differentially_expressed_genes_of_HNRNPC-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30597925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14358
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Clofarabine_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0184993
MSMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36099
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRABP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12172
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.2778
ANP32A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24704
BRD-A04231641	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22153
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52245
GSE223008_4_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7178
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.84239
DNAJB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59112
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.33365
GSE137914_4_v_3_tet3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210225_0_v_1_inosine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206270_2_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A00680357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1326
GSE210476_2_v_7_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE242199_2_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Harringtonine_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0114956
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0439
GSE147876,GSE147877_2_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0121316
GSE211931_2_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE239844_1_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.406913
negative regulation of gene expression	GO Biological Process Annotations 2023	1.0	null
GSE241036_4_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228606
BRD-K23835343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2792
GSE112762,GSE112767_1_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.788
CRCGN013_HEPG2_24H:L24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08094
BRD-K64716493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0084
Homoharringtonine_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0270455
BRD-K81810589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39761
LCLC103H	DepMap CRISPR Gene Dependency	1.0	2.42189
BRD-K93316985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64686
PMC11747033-Table1.xlsx-Sup_Table_S1-IFNy_LPS_TREATED_HMEC_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K19731191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60305
GSE180200,GSE180201_3_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K96510191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17149
RD_SOFT_TISSUE	CCLE Cell Line Proteomics	1.0	2.20847
PMC10534007-Table_2.xlsx-S1_overlap_MSC_up_B_V-438_common_elements_in_BFTC905_MSC_up_and_VM-CUB1_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K20203758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53903
BRD-K31783598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18012
L-type voltage-gated calcium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.972
PMC11408518-41598_2024_73146_MOESM5_ESM.xlsx-Intersection_gene-NCOA1_NCOA1	Rummagene Transcription Factor Associations 2026	1.0	null
Lucanthone_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00992981
GSE81803,GSE81912_2_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
ACTL6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.32529
RNA stabilization	GO Biological Process Annotations 2025	1.0	null
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225218_0_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K82202634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3006
GSE228619_0_v_1_cdh11_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAK-901_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0132782
BRD-K18944654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12499
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
MCF7_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0102647
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE247764_5_v_2_nell2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.127
PPP2R5E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19852
PMC9424213-41467_2022_32537_MOESM5_ESM.xlsx-HeLa_IER3-AS1sh_DEGs-DEGs_in_HeLa_IER3-AS1sh_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.06328
Preoptic area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.136
Bone marrow stromal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.047
CTV1DM	DepMap CRISPR Gene Dependency	1.0	8.81618
Bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.349
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE203485_1_v_0_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE237040_0_v_5_notch3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A91461229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2286
GSE211226_1_v_2_sirpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290457
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE154074_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Hnf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.7038
GSE161184_0_v_1_tlr7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122478
BRD-K47951404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35491
GSE159446,GSE159449_1_v_0_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225656_2_v_3_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF148	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46905
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100634_HIP_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.19253
MCF7_CUDC-907_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00996619
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.127
U2904	DepMap CRISPR Gene Dependency	1.0	4.50482
A549_Quisinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112754
GSE162739_2_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE124410_2_v_5_stk40_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12178829-mmc4.xlsx-Sheet_3-MEG3-KD_Down-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K10987837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69776
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mRNA binding	GO Molecular Function Annotations 2023	1.0	null
PEA1	DepMap CRISPR Gene Dependency	1.0	3.11154
MLST8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18538
plastid-encoded plastid RNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.713
BRD-K62318087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08672
BRD-K02719847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42547
GSE221020,GSE221023_2_v_1_pten_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A26583774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20998
MCF7_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180194
496100616_FWM_no dementia_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.01762
purine nucleotide metabolic process	GO Biological Process Annotations 2023	1.0	null