association	dataset	threshold value	standardized value
FADS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17728
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-3925-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MOLT-4	GDSC Cell Line Gene Expression Profiles	-1.0	-1.67005
meclocycline-1341	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CLC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17059
NMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70284
Histiocytic lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.659
GSE132948,GSE132949_0_v_1_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Basophil	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.609
CENPU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05935
ARGFX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73089
beta-escin-2194	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.04955
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-A8OU-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IC-86621-7548	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TTLL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05207
BRD-K95573463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69351
NEMF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9128
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Gene_Name_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5495-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TestisSeminiferousTubule	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.22883
Brain Lower Grade Glioma_LGG_TCGA-HT-7620-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hindgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.186577
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.678
valproic acid-6974	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_HEPG2_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52262
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.46348
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6481-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K95922469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65355
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
rats	GeneRIF Biological Term Annotations	1.0	null
rifamycin-sv	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.71467
characterized	GeneRIF Biological Term Annotations	1.0	null
MES304	DGIdb Drug Targets 2026	1.0	1.39295
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_Symbol_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPA-20513432-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ANXA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05329
PA-TU-8988S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854512
halcinonide-3680	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nipecotic acid-5999	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SFXN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85499
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.55836
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K86237035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44486
GSE133329_0_v_3_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
adiphenine-1872	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.463
AG-028671-6587	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.94764
fluvastatin-6691	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KIAA0040	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78191
GDI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50421
GIMEN	DepMap CRISPR Gene Dependency	1.0	4.95092
estradiol-2668	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXJ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45178
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
genistein-1015	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
bicuculline-4574	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC6487024-13148_2019_658_MOESM2_ESM.xlsx-S10-Pr_intrc_ADNP-1-Unnamed_1_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE112860_3_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Spermatogenic failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
ELF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76532
CRCGN010_HEPG2_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2853
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4970-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48778
TMEM35A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47544
iloprost-488	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.82701
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Hypogonadotropic hypogonadism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.012
TMBIM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91275
neurotransmitter receptor activity	GO Molecular Function Annotations 2015	1.0	null
CRCGN015_HEPG2_48H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.20644
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.027764
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.06032
BRD-K89277562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.323
Glucose intolerance	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
M-1	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.12406
metitepine-3231	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.779816
RPL29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15908
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.838109
levonorgestrel-3708	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2949-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.1945
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6275
RNF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49322
erastin-6417	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16545
VEZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7305
COGAR359	DepMap CRISPR Gene Dependency	1.0	5.17381
fenofibrate-2401	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056621
CREB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58456
BRD-A06158172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49229
GSE126345_4_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RIMS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39453
SNU1272	CCLE Cell Line Gene CNV Profiles	1.0	1.44041
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-0.938923
Prostate adenocarcinoma_PRAD_TCGA-EJ-5522-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPP6C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91081
meclocycline-6637	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CD24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7951
Brain Lower Grade Glioma_LGG_TCGA-HT-7856-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
meclozine-3285	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ketorolac-5988	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054566
DNAJC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90933
BRD-K07350528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28402
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.842401
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5641-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H1573	GDSC Cell Line Gene Expression Profiles	-1.0	-1.83852
benzonatate-1679	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060895
VSIG10L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35089
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3104
TACC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31252
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.566828
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061794
BBSome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.826
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.033202
azapropazone-6522	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LYPLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60981
SK-LU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DFCI024	CCLE Cell Line Gene Expression Profiles	1.0	1.95299
Accessory olfactory bulb	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
dexpropranolol-3553	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JURKAT	CCLE Cell Line Gene Expression Profiles	-1.0	-1.93693
dinoprostone-6547	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
orbital frontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40346
Lung squamous cell carcinoma_LUSC_TCGA-33-6737-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.872
fluspirilene-6662	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
trichostatin A-4237	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.80467
depression	GWASdb SNP-Phenotype Associations	1.0	0.365776
Hypogonadotropic hypogonadism 12 with or without anosmia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
piperidolate-3551	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28008
Neural lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.002
BRD-K25226763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12729
RAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64315
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16659
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7595-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TMEM250	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5837
peptide receptor activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K16633334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17832
RHOBTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68236
difenidol-2374	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
496100470_HIP_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.62752
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20253
TCF12	ENCODE Transcription Factor Targets	1.0	null
SMARCB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65296
BRD-K57115335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34924
GSE171837_3_v_1_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.134
prochlorperazine-6174	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05717
cell communication	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7468-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MRPL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26972
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.087847
LHFPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12934
PSRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48982
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.963851
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
SubthalamicNucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	2.23993
ASPC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.836131
Kidney Chromophobe_KICH_TCGA-KL-8329-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ovarian dysfunction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.056
cerebellar cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25365
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.65298
ZGLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02258
GPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62564
SK-MEL-24	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.80467
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27197
Prestwick-682-2819	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05524
fluorocurarine-6083	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mediodorsal nucleus of thalamus_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.36082
infundibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.696172
decamethonium bromide-7353	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04388
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HS751T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52102
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.57627
fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.236627
DCAF12L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12837
Prestwick-692-4599	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
increased luteinizing hormone level	MGI Mouse Phenotype Associations 2023	1.0	null
KOSC-2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.58876
tetracaine-2888	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.523982
BRD-K35441510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20335
SARS-CoV MA15_Day4-PFU-10^5_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.7471
DGKE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3781
zalcitabine-4799	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TE-6	GDSC Cell Line Gene Expression Profiles	-1.0	-1.58633
TFAP2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	167.254
acebutolol-6631	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
wortmannin-5240	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cellular response to organic substance	GO Biological Process Annotations 2015	1.0	null
Y-RFRP-3	DGIdb Drug Targets 2026	1.0	1.39295
HNF1B_OE_GDS1499_253_human_HEK293 embryonic kidney cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
primary motor cortex (area M1, area 4)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37595
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.101395
CYTH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25375
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30466
G protein-coupled peptide receptor activity	GO Molecular Function Annotations 2023	1.0	null
Cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6825-01A-21R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.10798
bipolar disorder	GWASdb SNP-Disease Associations	1.0	0.605359
BRD-K18296568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83798
HCC-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE198826,GSE198911_1_v_2_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
doxepin-2384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
superior parietal lobule, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.971636
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHA-00767505E-6550	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cell-cell signaling	GO Biological Process Annotations 2015	1.0	null
[125I]NPFF	DGIdb Drug Targets 2026	1.0	1.39295
metolazone-1514	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.965242
RAB8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82526
Infundibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.644
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RIC8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28674
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
liver	HPA Tissue Protein Expression Profiles	-1.0	-1.66732
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.19976
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4998-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06355852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1346
superior colliculus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.91949
UBE2N	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33787
Body size at age 10	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.752288
NCI-H28	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46254
H3K27me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46H-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Corticotropic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.797
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K30433551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17817
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.09216
ACBD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61299
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4186
MOLP8	CCLE Cell Line Gene CNV Profiles	-1.0	-1.98808
Rectum adenocarcinoma_READ_TCGA-EI-6513-01A-21R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GORAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04719
HES1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12083
terconazole-4407	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
laterodorsal part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16702
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YAPC	CCLE Cell Line Gene Expression Profiles	-1.0	-1.47468
IL4R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37369
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
skimmianine-6066	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MT-CO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65857
cefixime-1310	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
loracarbef-2970	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pineal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.371
Rectum adenocarcinoma_READ_TCGA-EI-6885-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CACO-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32091
NPFF	Guide to Pharmacology Protein Ligands of Receptors	1.0	null
H3K27me3_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
UBL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48348
RARA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88083
adrenosterone-6486	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7747-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIGLEC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65879
cuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.51253
E2F6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dilazep-2333	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854512
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Amenorrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
nordihydroguaiaretic acid-6983	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100450_HIP_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.62829
RTL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59751
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4630-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.923501
JHH6	CCLE Cell Line Gene CNV Profiles	1.0	1.57829
DNMBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55665
pyrithyldione-3482	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
naringin-3286	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
phenformin-21	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
ZNF136	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38258
Nucleus recessus lateralis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.937
GSE126345_9_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MJ	DepMap CRISPR Gene Dependency	1.0	4.04789
BPNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27341
anterior lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.857574
BRD-K43782839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2206
pizotifen-5491	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE107505_0_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.598
ZC3H13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78506
cefmetazole-2524	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-7107-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A4-Fuk	GDSC Cell Line Gene Expression Profiles	1.0	1.43886
SMARCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.08353
dihydrostreptomycin-2237	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IRX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34185
cefotiam-5361	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.890949
Pars distalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.173
imipramine-1685	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K05778965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08035
etofylline-2093	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
acute leukemia	GWASdb SNP-Phenotype Associations	1.0	0.403073
RCOR1	ENCODE Transcription Factor Targets	1.0	null
corpus luteum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.194703
Endopeduncular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.541
[<sup>125</sup>I]Y-RFRP-3	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
GSE149880_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K68836091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37624
FOXE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39085
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
salivarygland_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
ZFHX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91433
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A461-01A-41R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
buspirone-5343	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Metabolic disorders of biological oxidation enzymes	Reactome Pathways 2014	1.0	null
H3K27me3_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fenspiride-2106	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SCN5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42733
[<sup>125</sup>I]1DMe	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
cimetidine-4063	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
STAT5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31086
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.864
TENM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30462
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_199_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH929	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85589
CDC20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15163
gallamine triethiodide-2221	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
telenzepine-2388	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CREB1_01_194	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.38616
GPCRs class A rhodopsin like	WikiPathways Pathways 2024	1.0	null
GSTK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57886
6-bromoindirubin-3'-oxime-6589	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K31010207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2248
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.936424
thioridazine-6189	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80937
Ependymocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.008
PHF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69601
BRD-A44068497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.22658
Lung squamous cell carcinoma_LUSC_TCGA-56-8628-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.78882
Nuclear replication fork	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.399
medial preoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.995054
SMAGP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78798
VZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.06856
furaltadone-2554	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4763-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144838_1_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cumulus-oocyte complex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.679
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.225622
8-azaguanine-1670	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
flecainide-3761	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
testis_7a	HPA Tissue Sample Gene Expression Profiles	1.0	1.33363
BRD-K96154586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.51548
CHO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.345
Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A896-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068907
PMC9630632-Table1.XLSX-diff_exp_genes-Group_1_vs_2_AND_Group_2_vs_3_NOT_Group_1_vs_3_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5483-11A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brain	GTEx Tissue Gene Expression Profiles	1.0	1.27491
NR3C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65213
OSBPL1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76485
terguride-4633	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7374-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7481-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAL120	CCLE Cell Line Gene CNV Profiles	1.0	1.39238
trifluoperazine-5442	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K54647312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12387
Stria terminalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.852
valproic acid-5582	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.565631
GABRA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5047
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.864447
PMC5637904-PATH-243-193-s015.xlsx-human_down_in_ductal_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
PRMT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04765
Thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.089
methylergometrine-5303	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K82508779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03526
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057592
dimenhydrinate-2400	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K51448234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27328
nifedipine-1692	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-SI-A71Q-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neurohypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.949962
TAL1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE68156_3_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Area postrema	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.632
butoconazole-5388	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
membrane	GO Cellular Component Annotations 2015	1.0	null
BRD-K82933801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70965
hindbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.805213
BCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49914
TTC39C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65964
pentoxyverine-4649	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
C2BBE1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41525
YH-13	GDSC Cell Line Gene Expression Profiles	1.0	1.98597
NOMO1	DepMap CRISPR Gene Dependency	1.0	2.81466
STRBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.08574
trioxysalen-5736	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.10465
ELMO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99015
EZH2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21075720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17514
naltrexone-2047	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K48699175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22719
UFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32422
ABCC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71318
CDKN1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49067
PAX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24687
Opiate dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.404
tetrahydroalstonine-2748	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FKBP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65219
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44642
VANGL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.15859
BRCA1	ENCODE Transcription Factor Targets	1.0	null
ventral posterior medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.888671
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27me3_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ovarian	GeneRIF Biological Term Annotations	1.0	null
DU4475	DepMap CRISPR Gene Dependency	1.0	9.33522
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.82712
glimepiride-2154	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RHOQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69551
hypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.884591
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.832323
SIAH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56138
Hypoactive sexual desire disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.233
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4TZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47410882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05328
haloperidol-4678	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PLCPRF5	DepMap CRISPR Gene Dependency	1.0	3.25699
BRD-K63859730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09097
lycorine-3891	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34097
Germinal vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.924
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K00611112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50552
outer CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.941328
BRD-K74540252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52447
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01566
C32	DepMap CRISPR Gene Dependency	1.0	3.57252
SBNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45307
sirolimus-5975	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DNASE1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33262
HCC1954	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.11186
levomepromazine-3701	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
contribute	GeneRIF Biological Term Annotations	1.0	null
disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.052255
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
J-774A.1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.758
BRD-K07414059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47477
GMPPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74294
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.33354
dipyridamole-1517	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36678
Prestwick-674-4738	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TATDN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30294
KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ZNF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7403
prednisolone-7424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pallidohypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.40157
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20735575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38676
GSE220520_6_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TMCO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18341
disulfiram-5729	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
MELHO	DepMap CRISPR Gene Dependency	1.0	3.27987
H3K9me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE77795_0_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.7879
Lung squamous cell carcinoma_LUSC_TCGA-43-3394-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PCNX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74889
neuropeptide signaling pathway	GO Biological Process Annotations 2015	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66652
THAP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.66462
H3K9ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7222-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100466_PCx_probable Alzheimer's disease_no TBI_89_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.11629
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Temple syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.052
BRD-K90693562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68386
prednicarbate-3542	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PRKRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47547
neuroblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.361527
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A116-11A-12R-A26B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nomifensine-5863	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HDAC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1341
immune system cancer	GWASdb SNP-Disease Associations	1.0	0.235873
Prostate adenocarcinoma_PRAD_TCGA-HC-8266-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UACC893	DepMap CRISPR Gene Dependency	1.0	2.3304
cellular response to hormone stimulus	GO Biological Process Annotations 2025	1.0	null
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01924
ACTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06893
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.184853
response to chemical	GO Biological Process Annotations 2015	1.0	null
MZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.04777
GSE147669_2_v_1_tram2_human	RummaGEO Gene Perturbation Signatures	1.0	null
g-protein coupled receptor activity	GO Molecular Function Annotations 2015	1.0	null
ID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68426
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RF9	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
FGFR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1536
H3K9me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.832998
BRD-K87929769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.103
crotamiton-3050	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
phthalylsulfathiazole-3371	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
prazosin-5416	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H4K20me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AU565	CCLE Cell Line Gene CNV Profiles	1.0	1.59392
Neuropeptide FF receptor family	InterPro Predicted Protein Domain Annotations	1.0	null
indapamide-4335	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
C2BBE1	CCLE Cell Line Gene CNV Profiles	1.0	1.83458
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.94792
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1091
C5orf34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39426
ACTMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15255
BRD-K35128023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06045
RAB3GAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58578
LARP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85863
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-e-Classification_of_camel_SON_basal_genes_-_G_protein_coupled_receptors_SON	Rummagene Transcription Factor Associations 2026	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ZNF330	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17699
NINJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87562
subcuneiform nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.972213
celecoxib-206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LAMTOR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96207
piperacillin-3763	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Eye-melanocyte	Tabula Sapiens Gene-Cell Associations	1.0	0.925538
DTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6097
BRD-K50716325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15088
TAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08334
2-aminobenzenesulfonamide-3400	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.2415
H3K27me3_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Preoptic area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.222
LYAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0653
sulfametoxydiazine-5732	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
(+)-chelidonine-5760	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU-387	GDSC Cell Line Gene Expression Profiles	-1.0	-1.89154
SNU-449	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.836131
GSE153757,GSE153758_0_v_2_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE104508_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hydralazine-2311	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hypogonadism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.485505
MRPS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63443
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7773-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GP5D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42852
BRD-K19139070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10568
TWNK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40519
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
PPP4R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99914
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7035
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.822529
cefalonium-2921	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.84067
BRD-K85418917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.2697
tanespimycin-5914	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HSPA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66666
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28720546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19237
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6470-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Epithalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.619
CBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23501
HYOU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76707
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
berberine-2770	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sirolimus-921	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
solasodine-3749	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
buspirone-6743	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pentetic acid-4669	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Genetic Predisposition to Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
BRD-K49443464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69553
U178	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47473
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223662
NOTCH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99792
transverse gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.61776
BRD-K42873980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0191
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.936996
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10209
H3K4me3_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GJC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49652
CTCF_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ADAMTS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02277
AKAP8L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19704
female	GeneRIF Biological Term Annotations	1.0	null
lymph node	HPA Tissue Gene Expression Profiles	1.0	0.876516
neomycin-1383	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4896
ARPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25912
cefamandole-3696	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pivmecillinam-6014	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.189244
atracurium besilate-1702	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14368
suxibuzone-7163	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SHOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15622
follicle-stimulating hormone complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.588
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RE-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gnih	GeneRIF Biological Term Annotations	1.0	null
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	1.0	null
ambroxol-3238	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.43994
BRD-K88925664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61502
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.925799
RS11846	BioGPS Cell Line Gene Expression Profiles	1.0	0.851669
deferoxamine-485	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EVPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15378
trichostatin A-6143	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pirlindole-5497	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Posterior paraventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.783
H3K4me1_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HDAC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03569
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.10925
TBC1D20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04308
H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Neuronal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.499
citiolone-3930	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC10657376-41467_2023_43213_MOESM7_ESM.xlsx-DaNs_EBF1-Unnamed_6_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
SMYD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22957
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15252
azathioprine-1528	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K47903820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22445
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.2544
integral component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
levocabastine-3509	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NPVF	Guide to Pharmacology Protein Ligands of Receptors	1.0	null
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.2167
CRCGN010_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32595
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
FGD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35666
AG-013608-6395	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF146	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23078
BRD-K62841603	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02519
COV362	CCLE Cell Line Gene Expression Profiles	-1.0	-2.80714
Cilium	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
U343	CCLE Cell Line Gene Expression Profiles	1.0	1.45791
BRD-K51787437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90065
WDR35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33564
pioglitazone-7528	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sirolimus-6167	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
basal forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.29673
riluzole-2334	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
baclofen-1536	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06398048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54289
FXR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68729
SW756	COSMIC Cell Line Gene Mutation Profiles	1.0	null
clozapine-2644	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Mesothelioma_MESO_TCGA-NQ-A57I-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BIBP3226	DGIdb Drug Targets 2026	1.0	0.928631
PHYH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72682
UACC257	DepMap CRISPR Gene Dependency	1.0	3.32007
BCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47916
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.797
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Thygro-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K97263385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1639
E2F4	ENCODE Transcription Factor Targets	1.0	null
PMC9996951-40659_2023_417_MOESM3_ESM.xlsx-Osteo_vs_MSC_Array2_hypo_er_txt-1_UCSC_NAME_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
LTBR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42324
PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
inner SZ in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33162
DYNLT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39557
BRD-K36042673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00571
iproniazid-5458	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SOX9	ChEA Transcription Factor Targets	1.0	null
ipratropium bromide-2762	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COMPOUND 46 [PMID: 25268943]	DGIdb Drug Targets 2026	1.0	1.39295
ZNF524	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08161
TRIM16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01786
benzathine benzylpenicillin-2939	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lymphnode_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.973503
Posterior periventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.441
C1QL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.2152
BRD-A81407814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59351
SCAMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00357
GSE145639_1_v_6_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM265	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58542
CRCGN009_HEPG2_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07265
rilmenidine-3133	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17107214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02263
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF684	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.2221
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6022-01A-21R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCARA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80312
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.54636
HSFY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17109
fludrocortisone-2368	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7315-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0825
cycloserine-7134	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H1-7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99308
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.040851
ondansetron-3575	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF184	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21935
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	3.4231
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
eucatropine-3935	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lateral orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15207
pseudopelletierine-2766	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
Axon terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.452
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.907173
layer IIIu of area 35r	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16398
heptaminol-1703	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
left colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.302838
increased susceptibility to weight loss	MGI Mouse Phenotype Associations 2023	1.0	null
Pain agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.182
C3orf18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45239
N-acetyl-L-aspartic acid-1329	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_HEPG2_48H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.88078
response to stimulus	GO Biological Process Annotations 2015	1.0	null
SAMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48154
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z3-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82935855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93059
nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.325327
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.94428
ZNF721	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31923
PRC1_BMI_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
KDM5B-21448134-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.05842
response to organic substance	GO Biological Process Annotations 2015	1.0	null
ES-WA7 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.56812
NME1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54041
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.35172
tonzonium bromide-3080	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5298
trifluoperazine-2684	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
oxedrine-3578	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7861-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
wortmannin-7002	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K92432769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.255
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
preoptic area	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.796041
TSPAN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02196
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.34926
Substance dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
BRD-K26431593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0564
cerebellar cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25935
TE1	CCLE Cell Line Gene CNV Profiles	1.0	1.68507
testis_7f	HPA Tissue Sample Gene Expression Profiles	1.0	0.879395
ATOH7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6661
H3K27me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5942-01A-21R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TOMM40L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79577
NADK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07369
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
Signal Transduction	Reactome Pathways 2024	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
CRCGN015_MCF10A_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.12522
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cv-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.195607
benzthiazide-2989	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
normal	GeneRIF Biological Term Annotations	1.0	null
ECPAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7001
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
phenylpropanolamine-6699	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
salivarygland_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00485
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.25617
MRPS17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87542
HTR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9434
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.3813
Central precocious puberty	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.074
BRD-K00909602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90869
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.73593
inferior olive, medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.28173
pivampicillin-5465	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FGFR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0888
BRD-K50423606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01749
BRD-K36208388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90089
acetylsalicylic acid-1629	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TJAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.14099
Eye-retinal pigment epithelial cell	Tabula Sapiens Gene-Cell Associations	1.0	0.334021
GSE63048_11_v_8_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
U87	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.98657
MED19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16875
FAM236B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47945
PHOX2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02817
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5ST-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562	BioGPS Cell Line Gene Expression Profiles	1.0	0.916
KYSE-30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE179002_2_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF	ENCODE Transcription Factor Targets	1.0	null
fibroblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.076071
Prestwick-665-3681	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12873_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49338
TRERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.673
proxyphylline-3115	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
amygdaloid complex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.73642
TMX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70805
bone cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056587
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	1.0	5.00224
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NB-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
prenylamine-5489	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16462
3-acetylcoumarin-5259	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
flucytosine-3073	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PLAG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96181
Kidney Chromophobe_KICH_TCGA-KN-8434-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bone cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071666
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.061632
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.258
BRPF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44622
pentolonium-2305	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
buflomedil-3274	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A114-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Chloroplast envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.348
H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PLAGL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.1541
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.9551
zuclopenthixol-7356	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IGFBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82788
bisoprolol-6748	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
vagina	GTEx Tissue Gene Expression Profiles	1.0	0.857096
HUG1N	CCLE Cell Line Gene CNV Profiles	1.0	1.33011
HCC2108	CCLE Cell Line Gene Expression Profiles	-1.0	-2.03984
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cognitive decline rate in late mild cognitive impairment	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.709691
TRIM14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26298
corynanthine-4227	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GATA2-21186366-BM-HSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K05940224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8374
H3K4me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
11-deoxy-16,16-dimethylprostaglandin E2-7538	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SOX9-22984422-TESTIS-RAT	ChEA Transcription Factor Targets 2022	1.0	null
H3K9ac_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PF-00539758-00-6379	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LARGE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92441
bethanechol-5539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.226926
Paraventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.175
methyldopate-6640	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KHDRBS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24514
GSE147834_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PLCXD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25405
FAM43A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37521
atropine-2761	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAD21_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kaempferol-7196	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVKATE	CCLE Cell Line Gene CNV Profiles	1.0	1.49787
IZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.63982
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5187-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
foliosidine-3739	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K51525251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85812
ovary cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061622
GSE237040_4_v_3_notch3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
clorgiline-5005	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dacarbazine-4480	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MBTPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45213
SLC43A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9237
PF-01378883-00-6368	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-78-7633-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
H3K27me3_bronchial epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:A24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08385
CRCGN015_HEPG2_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.62525
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tolbutamide-3886	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE179002_0_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061253
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.19118
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.069338
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07618
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12228
brain ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.447192
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.35417
Perturb_2089_OE_hTR_SRP179030	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
TSPYL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42604
TOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00749
TBC1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49683
myosmine-3737	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intermediate portion of DFC (area 9/46)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32486
SUDHL1	CCLE Cell Line Gene Expression Profiles	1.0	1.45261
PPY	Guide to Pharmacology Protein Ligands of Receptors	1.0	null
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00001
BRD-K49529874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14364
alprostadil-4099	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BLOC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.736
KKU100	DepMap CRISPR Gene Dependency	1.0	2.081
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59191
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.32179
PIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81238
VDR-24787735-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K66030669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91903
ABHD15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40333
KNS81	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58731
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
layer III of rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.58689
florfenicol-6460	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE173873_8_v_6_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RBBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77478
Perturb_753_KD_ABAT_SRP385901	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.92942
Leydig cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.546
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6977
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A69097282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14779
H3K27me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A23R-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.044203
FZD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53015
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4901-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Squamous cell lung carcinoma	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
Hyperalgesia	DisGeNET Gene-Phenotype Associations	1.0	null
GSE153757,GSE153758_1_v_2_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20663
HUP-T4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Central amygdaloid nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.027
Supraoptic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.448
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Significant_DE_genes_in_AKT1_vs_KLF4_meningiomas_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
furaltadone-3932	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
IGF2R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73669
TRIM44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47735
GPCR ligand binding	Reactome Pathways 2024	1.0	null
etidronic acid-3325	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16659
EBLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43944
abnormality of cellular immune system	GWASdb SNP-Phenotype Associations	1.0	0.121887
CLDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08426
GSS	CCLE Cell Line Gene CNV Profiles	1.0	1.98761
ZNF563	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82976
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLF1-20508144-FETAL-LIVER-ERYTHROID-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
sirolimus-6201	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CAPAN-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854512
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28919
Fasciolar gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.775
ependymal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.274744
NR5A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67849
Acute lymphoblastic leukemia (childhood)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.509691
Spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.504
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spinal cord	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-A54G-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K41025232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3437
sertaconazole-6811	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SETD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16358
Neuroactive ligand-receptor interaction	KEGG Pathways 2026	1.0	null
GSE203158_1_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K90644597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26395
SOX11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4362
ARHGDIG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65534
ranitidine-5425	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
fusidic acid-6754	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hymecromone-5684	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NANOG-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
bupropion-1564	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9861
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68859
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
WDR86	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87302
RIPPLY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62732
KLF1	ChEA Transcription Factor Targets	1.0	null
[3H]NPVF	DGIdb Drug Targets 2026	1.0	2.78589
BRD-K32947579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23149
noscapine-2745	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Plastid envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.306
PMC7305081-10120_2020_1045_MOESM1_ESM.xlsx-Tab2-Mutation-MAF_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
paroxetine-3821	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BEND3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79365
piperidolate-6129	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OLIG3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5024
GJB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.81416
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.5365
BRD-K40474424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.63223
BRD-K09521953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71929
CHD2	ENCODE Transcription Factor Targets	1.0	null
COPRS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01209
COPS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15546
carbachol-6742	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
testis_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.14753
GSE210885_5_v_4_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PARP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23991
CNOT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82637
mature ovarian follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.235167
OVCAR8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.79234
nocodazole-7145	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7012-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD23A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63294
RAD21	ENCODE Transcription Factor Targets	1.0	null
leukemia	GWASdb SNP-Phenotype Associations	1.0	0.29473
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
eldeline-6026	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tonzonium bromide-5678	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DLG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7622
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
thioridazine-2690	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ANO8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7162
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06500446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1149
anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71952
mafenide-2124	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bicuculline-4397	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
methanthelinium bromide-6137	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LCN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07215
BRD-K25187028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06688
BRD-K06475386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23178
Neuropeptide FF receptor, type 1	InterPro Predicted Protein Domain Annotations	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
metoclopramide-3728	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PPP3CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49104
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LN428	CCLE Cell Line Gene Expression Profiles	1.0	2.22726
gut	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.080558
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28454
tropicamide-4744	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE142630_0_v_2_hiltonol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8162-01A-21R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AKAP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11739
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.063888
GP2D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53348
PMC7064337-elife-51373-supp1.xlsx-EZH2_targets_shPHF19-List_of_2084_genes_marked_by_EZH2_ChIPseq_after_PHF19_KD_shPHF19_AR	Rummagene Transcription Factor Associations 2026	1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056258
SUM1315MO2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.71319
CTCF_GM13977_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K26809097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0531
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Medial septum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.458
EFWSLAAPQRF-NH2	DGIdb Drug Targets 2026	1.0	1.39295
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
tolfenamic acid-2120	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.925799
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.31674
G protein-coupled receptor heterodimeric complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.574
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THAP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87073
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10209
SNX19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75372
decreasing	GeneRIF Biological Term Annotations	1.0	null
BRD-K11275619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24052
H3K9me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCAPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42911
CTV1DM	DepMap CRISPR Gene Dependency	1.0	2.94174
vidarabine-5850	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PO-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LHX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84531
BRD-K50721666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08744
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4864-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF684	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20179
H3K27me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K59159023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1579
sulfamethoxypyridazine-2550	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CP-320650-01-4557	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
carisoprodol-1314	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4327
PMC6928094-395_2019_765_MOESM7_ESM.xls-DEGs_AR7_vs_Pre-patterned-List_of_differentially_expressed_genes_in_AR7_vs_Pre-patterned_cells_THRA	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF710	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7631
BRD-K13076765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58143
EMILIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85458
YWHAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77094
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CPNE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46492
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
Acute Myeloid Leukemia_LAML_TCGA-AB-2898-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELAVL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71096
AIFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61421
germ layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078883
substance-related disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8769
SKMEL3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4139
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ES-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14219
BRD-K28433349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8552
GSE173873_8_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ANXA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7626
CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE111035,GSE111040_3_v_12_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pituitary	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4173-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56373
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0089
YTHDF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65009
single-organism process	GO Biological Process Annotations 2015	1.0	null
Dorsal raphe nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.061
ZFP69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93919
OTUD7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8295
simvastatin-4244	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FASTKD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20835
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.977537
H3K27me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EKVX	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.5428
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.85472
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.340539
KDM5B	ENCODE Transcription Factor Targets	1.0	null
APOBEC3H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.99672
SMURF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79293
bepridil-2629	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.949523
KYM1	DepMap CRISPR Gene Dependency	1.0	4.34788
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NN-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A26952628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97743
BRD-K12097074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54501
GPCR, rhodopsin-like, 7TM	InterPro Predicted Protein Domain Annotations	1.0	null
CDC25A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3536
fibroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070672
alverine-2110	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
thiamazole-4550	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
papaverine-5769	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TIGAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63945
SMAD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98675
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70G-01B-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hindbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.305
BRD-K27754030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23139
mesoridazine-2874	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cetirizine-4231	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
praziquantel-5874	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05316
sotalol-2918	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pindolol-4496	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAGED4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00234
sotalol-7338	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
finasteride-3744	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058734
HERC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19643
CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063002
CRCGN016_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6336
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH929	CCLE Cell Line Gene Expression Profiles	1.0	1.52086
GSE152637_1_v_0_imiquimod_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6215
SYT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49344
MCAS	CCLE Cell Line Gene CNV Profiles	1.0	1.39448
cefoxitin-7148	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PLEKHG4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11155
BRD-K11442063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.3423
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.14726
ZMYM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70065
UBXN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62575
RPMI-8402	GDSC Cell Line Gene Expression Profiles	-1.0	-1.63899
ovary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.2723
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K40745976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13068
EZH2-27294783-CHIP-SEQ-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
benzamil-6056	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
rosiglitazone-1658	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NDRG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53593
Orexin and neuropeptides FF and QRFP bind to their respective receptors	Reactome Pathways 2014	1.0	null
bupropion-6256	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KIAA1143	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43794
PAFAH1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79393
Pituitary gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.958
RBFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57801
BRD-K73524144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33976
pronetalol-2902	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NDUFAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2447
folic acid-1790	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE179002_3_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate-myeloid cell	Tabula Sapiens Gene-Cell Associations	1.0	3.58736
RTCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01286
anteromedial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00825
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.837723
homatropine-5477	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVKATE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.11143
Acute lymphoblastic leukemia (childhood)	GWAS Catalog SNP-Phenotype Associations	1.0	0.048624
nifedipine-603	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
eldeline-3750	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9733061-13059_2022_2800_MOESM5_ESM.xlsx-Table_S4-Table_S4_Genes_assigned_to_JUNB_binding_sites_Each_peak_was_assigned_to_the_nearest_TSS_JUNB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K18406496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02919
cephaeline-5247	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
SLC25A15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1521
guanabenz-5703	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nitrofural-6721	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
theca folliculi	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.177708
BRD-K23292451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05287
KLHDC7A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63323
BRD-K68985225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0211
RPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69344
PRR14L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83665
tiletamine-6516	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
SIMA	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69969
N-acetyl-L-leucine-4622	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K84118789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22247
eticlopride-3056	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
indoprofen-4249	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.99
BRD-K77540020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04279
Basal forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.526
gentamicin-5883	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00038
tolfenamic acid-5454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_C2C12_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10916124-12864_2024_10174_MOESM1_ESM.xlsx-Supplementary_Table_6-The_downstream_genes_targeted_by_FLI1_The_ligand_vs_receptor_pairs_genes_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
lynestrenol-5355	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K12913157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34276
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TLR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30346
Brain Lower Grade Glioma_LGG_TCGA-DU-A76R-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsalstriatum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.26367
risperidone-3508	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40629
Lung squamous cell carcinoma_LUSC_TCGA-63-6202-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AC262620	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Kallmann syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
procarbazine-2971	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K74767736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11002
bemegride-5014	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Adenohypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.229
COS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.707
UFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82697
probenecid-4771	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MRK-nu-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.54818
BRD-K84235037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11951
PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K50300854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39752
mepenzolate bromide-6024	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN014_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92941
LYSMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41004
CCNK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74991
Prestwick-984-2903	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
cefalonium-4245	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GATA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54697
theca cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.410111
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.977237
Peptide ligand-binding receptors	Reactome Pathways 2024	1.0	null
RRP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32243
ZNF738	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74262
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057242
finasteride-2206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GCLM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4701
AP3M1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44075
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
pars tuberalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.747927
Olfactory placode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.861
GIPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.29381
BRD-K12239796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98902
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-2.16468
levopropoxyphene-5503	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CACHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8053
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7841-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.836697
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.79228
primaquine-1343	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
MCM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40915
PC-3	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
PMC10082806-42003_2023_4756_MOESM4_ESM.xlsx-AML2_RelvsTum_DMRs_anno-annot_symbol_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
ABHD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47229
fludroxycortide-6039	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
UBQLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.80959
nomifensine-1378	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
luteal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.306805
KARPAS422	DepMap CRISPR Gene Dependency	1.0	4.57173
peaking	GeneRIF Biological Term Annotations	1.0	null
response to nitrogen compound	GO Biological Process Annotations 2015	1.0	null
BRD-K42754852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34851
LMBR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28878
epivincamine-2775	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
harmalol-2892	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DNAJC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32619
clopamide-5402	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26326
PPARGC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66659
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lincomycin-7411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
placenta_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055328
primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.830398
CERS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57571
pain agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.26298
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7583-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HB-75-KT12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21538
BRD-K58248556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07421
G protein-coupled receptor activity	GO Molecular Function Annotations 2025	1.0	null
nisoxetine-6496	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4836
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.9874
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.32569
methylbenzethonium chloride-2190	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
molindone-2917	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
H3K9me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
niflumic acid-2399	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
REH	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LRR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2517
BRD-K29039402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31496
COQ3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73815
NKX2-3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80208
[<sup>125</sup>I]NPFF	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Disease	Reactome Pathways 2014	1.0	null
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5633-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mefloquine-2210	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Plastid inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.406
SNU668	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46456
MYO1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76691
CTCF_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.852783
salbutamol-3677	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.198769
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE232944_1_v_0_ctnnb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.892398
AEBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82601
flumetasone-2551	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.98178
PAX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54122
methylprednisolone-7137	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.66732
MON	DepMap CRISPR Gene Dependency	1.0	3.69013
TPD52L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06997
placenta_3a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
day	GeneRIF Biological Term Annotations	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CingulateCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.47971
metanephrine-1515	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SUM52PE	DepMap CRISPR Gene Dependency	1.0	8.71695
RRN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88206
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7473
PLAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91263
TMEM69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57438
GPCR downstream signaling	Reactome Pathways 2014	1.0	null
GSE113329,GSE113335_2_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5673
AP2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82695
SF767	CCLE Cell Line Gene CNV Profiles	1.0	2.30725
GSE114258_1_v_2_foxk1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.3297
naphazoline-4949	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K97255584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09484
BRD-K12862541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21442
pentoxifylline-6021	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64399
DNAJC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89372
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
aciclovir-1543	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE95685_2_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
acute lymphatic leukemia	GWASdb SNP-Phenotype Associations	1.0	0.868241
SMYD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34159
SYNGR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57479
CDX2-21402776-INTESTINAL-VILLUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
FTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.53822
IGFBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76162
TRDMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24074
mestranol-3346	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
basal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.281776
sulfadiazine-5523	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OVMIU	DepMap CRISPR Gene Dependency	1.0	3.63698
OCT4-21477851-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K74677971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5723
cellular response to hormone stimulus	GO Biological Process Annotations 2023	1.0	null
valproic acid-1665	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.953455
H3K27me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K20415826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.48751
GLI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44036
GSE182680,GSE182683_5_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
butoconazole-3288	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88651
ZDHHC18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47365
DAXX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41067
arcuate nucleus of medulla, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.958992
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WA-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
finasteride-3641	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
amygdala	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.575216
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07981
cos-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.395709
FUCA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06291
SW403	DepMap CRISPR Gene Dependency	1.0	5.55215
A-Netherlands-602-2009(H1N1)_48Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-3.08032
BRD-K87259147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1401
UBE2L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41699
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
SLC19A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.62875
ARTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01491
benzamil-3738	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SCN4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18705
cefotaxime-7186	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.078522
SCARF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0346
GSE112860_3_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.10773
WM-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.14934
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96616
CRCGN015_MCF10A_48H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33789
azlocillin-3468	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
paraventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.02031
PRR35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4966
Globus pallidus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.079
RREB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6995
xamoterol-5363	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE95685_4_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NPFF	Pathway Commons Protein-Protein Interactions	1.0	null
MOGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30721
BRD-K02783902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59342
GSE239898,GSE239899_1_v_0_hiltonol_human	RummaGEO Drug Perturbation Signatures	1.0	null
monorden-4443	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tamoxifen-2212	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
expressions	GeneRIF Biological Term Annotations	1.0	null
BRD-K54751293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01987
MFSD14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.1538
receptor activity	GO Molecular Function Annotations 2015	1.0	null
H4C16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.93741
BRD-K57468571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56123
Sarcoma_SARC_TCGA-QQ-A8VG-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63107801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00213
STOCK1N-35215-6380	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
promazine-3752	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K45398957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13924
BRD-K95218317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01778
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.995032
WM983B	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50813
CP-863187-7508	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_GM12867_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM63B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6275
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.845159
Lung squamous cell carcinoma_LUSC_TCGA-43-2581-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE140997_4_v_8_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:K04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56419
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3M9-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19522
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.32775
thyroid_5d	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
LSM12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55621
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
arcaine-3349	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PVRIG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54347
interstitial nucleus of Cajal, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05318
Perturb_1297_KO_Trp53_SRP298760	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.71219
droperidol-4629	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EC-01A-21R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PTPRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8012
cromoglicic acid-5754	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
layer III of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01438
Pituitary gonadotropin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.459
metformin-61	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K22039769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12853
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42784
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF551	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73601
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
idoxuridine-1899	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nordihydroguaiaretic acid-4447	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cyproheptadine-5340	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20628
H3K9ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
sertaconazole-3550	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cos cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.276846
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.83302
GPCRs, Class A Rhodopsin-like(Homo sapiens)	WikiPathways Pathways 2014	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.983374
penbutolol-3534	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inner CP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.51393
primary auditory cortex (core)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02229
PF-00562151-00-6868	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8214
boldine-2148	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE107505_1_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.931877
SLR20	DepMap CRISPR Gene Dependency	1.0	2.67733
geldanamycin-2688	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lidoflazine-6278	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sarcoma_SARC_TCGA-UE-A6QU-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF677	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46827
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.34309
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
oxaprozin-4530	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ESD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83845
saos-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.256902
GRTP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96362
IL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08707
lomefloxacin-3723	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_HEPG2_48H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.61214
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.956104
nisoxetine-5516	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
PIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52367
FOXO1-25302145-T-LYMPHOCYTE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.06558
CRCGN015_HEPG2_48H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.73618
increases	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
large intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057143
CRCGN015_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1303
SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	167.293
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.879065
BRD-K33767223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49096
CBX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55518
thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.12483
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.52983
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ASPHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71673
Habenular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.641
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64005
TNFRSF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28211
placenta_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
GSE198054,GSE198057_0_v_1_csf1r_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NO-10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Inhibin B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.653
hydralazine-2349	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KRAS.KIDNEY_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4798-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
meropenem-6141	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
esculin-6310	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.865633
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LRP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.87587
H3K27me3_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUAK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24952
polymorphic layer of rostral subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.949217
cefalexin-2628	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
scopolamine N-oxide-2099	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SYCE1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16282
RNPEP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79315
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D5-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
long insular gyri, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14361
HDAC6	ENCODE Transcription Factor Targets	1.0	null
H3K27me3_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEV_60Day_None_GSE53731	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.13221
GSE220520_6_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
quinpirole-3539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
procarbazine-3533	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
chlortetracycline-1541	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RELL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32824
BRD-K11054031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53958
BRD-K45471346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11693
LN18	DepMap CRISPR Gene Dependency	1.0	2.02951
MCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01003
milrinone-3552	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0187
USF2	ENCODE Transcription Factor Targets	1.0	null
PMC11148097-41698_2024_569_MOESM2_ESM.pdf-223-IRF3_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
CELSR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90182
posteroventral (inferior) parietal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.73642
H3K9me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81E-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.70535
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CALB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42463
CRCGN010_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24376
CRCGN015_MCF10A.TP53.M_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05429
BRD-K57262525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07162
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16995
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-8121-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041309
LMNA_Lmna Gly609Gly knock-in_GDS4490_615_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE185519_3_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CREBRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96022
PPP3R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25129
BRD-K56034970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00491
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF497	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92643
FIS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22744
estradiol-4432	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
infundibulum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.03873
LY-294002-6195	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nalidixic acid-2297	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KIDINS220	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24184
MEIOB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18713
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.54952
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81654
cloperastine-3608	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K24170552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09728
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7754-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ketotifen-3200	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
skimmianine-6242	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_MCF10A_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14329
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE132948,GSE132949_0_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
remoxipride-5443	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FLNA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73544
647-V	COSMIC Cell Line Gene Mutation Profiles	1.0	null
gentamicin-2245	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SEC24D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74631
CHD1	ENCODE Transcription Factor Targets	1.0	null
BRD-K34604637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55628
GSE195786_0_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cinchonidine-2772	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Septal area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.057
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.60241
neuropeptide signaling pathway	GO Biological Process Annotations 2025	1.0	null
increased litter size	MGI Mouse Phenotype Associations 2023	1.0	null
oxybuprocaine-3996	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06015
CRCGN015_HEPG2_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.63716
H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cefadroxil-1323	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.22897
neuropeptide receptor activity	GO Molecular Function Annotations 2015	1.0	null
idazoxan-5347	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.804796
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64565
CHD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79191
TMEM92	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7817
Urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
SKMEL24	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53984
HNRNPH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29038
AGPAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.371
CRCGN017_MCF10A.TP53.M_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.6924
naringenin-1342	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.29178
LU-134-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
neuropeptide receptor activity	GO Molecular Function Annotations 2025	1.0	null
TAL1-21186366-BM-HSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ROS50	DepMap CRISPR Gene Dependency	1.0	2.46515
meclofenoxate-3605	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
kawain-4693	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
N6-methyladenosine-5332	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SN-01A-12R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.45492
MIS18BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08338
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.955862
hypothalamus	GeneRIF Biological Term Annotations	1.0	null
MOAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39451
progesterone-3287	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
flutamide-2358	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tacrine-6698	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K93127164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48106
peptide binding	GO Molecular Function Annotations 2015	1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Anterior paraventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
Lung squamous cell carcinoma_LUSC_TCGA-56-8624-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54295
CRCGN014_HEPG2_24H:A08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14785
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KLK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26576
GSE155031_5_v_1_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nuclear replisome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.421
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4918-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EP300_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF623	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.52461
Lung adenocarcinoma_LUAD_TCGA-MP-A4TC-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fluphenazine-5234	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF177	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35904
BRD-K47794327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06169
meticrane-1792	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6943-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
stratum lacunosum-moleculare of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.875459
EHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14153
PAK1IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97385
ketoprofen-4751	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4862-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ozagrel-3503	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
enzalutamide_homo sapiens_gpl570_gse44905	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.20188
OTX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51177
leukemia	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.052255
MRPS27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06858
BRD-K62620616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34808
GSE126345_7_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SREBF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8847
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06454
CRCGN017_MCF10A.TP53.M_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4098
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K62800316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08609
difenidol-7406	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K24387453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01003
diethylcarbamazine-7425	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SLR21	CCLE Cell Line Gene Expression Profiles	1.0	1.43305
FHIP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83906
BRD-K11715561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.37344
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
Plasma membrane bounded cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
TTLL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4732
genistein-5595	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LN319	CCLE Cell Line Gene Expression Profiles	1.0	1.89844
pralidoxime-3066	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
reserpine-3341	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
CTBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44154
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.571
neoplasm by anatomical site	GWASdb SNP-Phenotype Associations	1.0	0.05678
UBN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23788
inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1596
FERD3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03761
BRD-K39809702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5926
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
median eminence	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.05941
SLFN13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71959
chlorambucil-3869	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
etiocholanolone-3742	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K28429328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29255
indometacin-503	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A68865339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01556
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.994995
H3K27me3_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97624648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46039
CRCGN015_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.51624
1DME	DGIdb Drug Targets 2026	1.0	1.39295
METTL26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82773
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02143
propranolol-3396	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SGSM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59247
mianserin-2231	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2643
VSX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32345
ITM2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1914
NFKBIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80646
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18255
H3K27me3_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAB40AL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.38029
buflomedil-1338	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HNRNPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.16852
THP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.31986
YAPC	GDSC Cell Line Gene Expression Profiles	-1.0	-1.55198
BRD-K97977764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06342
nifuroxazide-4253	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2649
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051912
acute leukemia	GWASdb SNP-Disease Associations	1.0	0.986376
dorzolamide-3565	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.276821
hexamethonium bromide-1482	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K04108962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1613
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
FOXH1-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
thioridazine-1655	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ATP6V0A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07681
CRCGN015_MCF10A.TP53.M_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4361
WARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7417
GATA3	JASPAR Predicted Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4737-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.8071
MRPL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30043
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
pedunculo(pontine) tegmental  nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0942
endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.080173
parolfactory gyri, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.33975
Rectum adenocarcinoma_READ_TCGA-EI-6511-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IBMX	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1241
Signaling by GPCR	Reactome Pathways 2024	1.0	null
BRD-K47415214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04175
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE200673,GSE200691_2_v_3_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Ciliary tip	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.726
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44226
stratum lacunosum-moleculare of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14706
sk-n-mc cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.484766
STX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50944
S100A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95286
cloperastine-2549	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
citalopram-3820	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7469-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial portion of the shell	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.864601
BRD-K82927098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29333
PCDH8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01604
SK-MEL-2	GDSC Cell Line Gene Expression Profiles	-1.0	-2.73688
A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_7day-MOI-10^4_None_GSE43301	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.91352
FBLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62591
cellular response to chemical stimulus	GO Biological Process Annotations 2015	1.0	null
BRD-K61438422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02401
anterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.59533
BRD-K96652989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02358
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6994-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH524	CCLE Cell Line Gene CNV Profiles	-1.0	-2.05662
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47408
BRD-K52634604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11364
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02022
BRD-K44212150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18176
G alpha (q) signalling events	Reactome Pathways 2024	1.0	null
SKOV3	BioGPS Cell Line Gene Expression Profiles	1.0	0.976176
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.42141
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8635809-Table_2.xls-LPS-upregulated-Unnamed_4_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
GCNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01919
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.488
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LUZP1-20508642-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K94913508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62819
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96817767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01619
trimipramine-4083	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.438
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K17840858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4442
KNOP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6446
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.929312
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-6087-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A9DD-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07695007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.57184
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.974854
sulfamethoxypyridazine-3711	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ovarian follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214765
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058745
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47922
BRD-K76885311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2727
Meynert's basal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.676
KISSPEPTIN-10	DGIdb Drug Targets 2026	1.0	0.928631
MPV17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51393
KARPAS299	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46428
Lung squamous cell carcinoma_LUSC_TCGA-22-5489-11A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.45388
OELE	CCLE Cell Line Gene Expression Profiles	1.0	1.88177
cingulate gyrus, parietal part, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1025
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USP34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90361
oleandomycin-4615	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.587521
SP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60322
cellular response to endogenous stimulus	GO Biological Process Annotations 2015	1.0	null
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.27728
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.218398
INTS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92783
ZSCAN30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46486
BRD-K84233319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15209
Lung	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
hippocampus (hippocampal formation)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.900205
PMC7579924-12920_2020_778_MOESM3_ESM.xlsx-AA-Gene_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
EI24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66064
SERPINE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41446
cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.052255
signal transducer activity	GO Molecular Function Annotations 2015	1.0	null
vestibular nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.53362
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5325-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	144.591
TC71	CCLE Cell Line Gene Expression Profiles	1.0	1.35821
BRD-K02087489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33546
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_6_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
ITGA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62082
tail of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03433
SNU520	CCLE Cell Line Gene Expression Profiles	-1.0	-1.79773
ventrolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39043
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
ADRA2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07334
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K48129913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39946
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.958826
Corpus albicans	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.002
DYNC1H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67025
CTCF_GM12868_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
parahippocampal gyrus, right, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.864172
valdecoxib-6378	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MIEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89397
PATU8902	CCLE Cell Line Gene CNV Profiles	1.0	1.4894
SLR20	CCLE Cell Line Gene Expression Profiles	1.0	1.56481
myosmine-2199	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6871
P2URK562	DepMap CRISPR Gene Dependency	1.0	5.00595
EIF2B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74606
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.933645
MCRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74349
mephenytoin-6275	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN008_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.7233
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06371
GSE200673,GSE200691_2_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6499311-supp_gr.243345.118_Supplemental_Table_S8.xlsx-S8B_Het1A-HNF4A_2d_5x_open-Nearest_Ensembl_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K68594161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12334
CAKI-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.5218
ZNF462	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65597
BRD-A88237615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1758
increased circulating luteinizing hormone level	MGI Mouse Phenotype Associations 2023	1.0	null
TNNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6236
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059729
ETV3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61466
CRCGN014_HEPG2_3H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02072
Brain Lower Grade Glioma_LGG_TCGA-FG-7638-01B-12R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WM115	DepMap CRISPR Gene Dependency	1.0	4.40374
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PP-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKNMC	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59889
CRCGN015_HEPG2_48H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00136
RXRA-24833708-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.52809
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.905144
picotamide-1387	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cell body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.049
IFITM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60253
H3C3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47332
PPP1R13L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44994
BRD-A05828965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38314
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
clemizole-3672	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ARIH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17187
GSE206516,GSE206518_1_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SW982	DepMap CRISPR Gene Dependency	1.0	3.26442
ZR75_1	BioGPS Cell Line Gene Expression Profiles	1.0	2.0814
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
erastin-6369	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GPR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65059
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NAMALWA	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78047
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72457
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.211933
HCN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63789
PC14	DepMap CRISPR Gene Dependency	1.0	2.39868
BRD-K62942008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0362
ECI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69768
tranexamic acid-2085	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.25597
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052974
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3378-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36076
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34551
Roe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.724
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hexetidine-2457	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
loxapine-1516	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE111660_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12719
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.02022
minocycline-2405	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
response to organonitrogen compound	GO Biological Process Annotations 2015	1.0	null
Prestwick-864-2994	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.47349
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00485
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.757845
ERP29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22333
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2516
NCOA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46834
SK-MES-1	GDSC Cell Line Gene Expression Profiles	1.0	1.73175
CRCGN017_MCF10A.WT.HP_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9045
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4568
colon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059159
ventrolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861098
coralyne-2652	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prestwick-984-7323	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
tetracycline-2243	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DN-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CP-690334-01-4561	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_HEPG2_48H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.48167
cellular response to stimulus	GO Biological Process Annotations 2015	1.0	null
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	Reactome Pathways 2014	1.0	null
BRD-K60782883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62626
CRCGN015_HEPG2_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.44456
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28372
lidocaine-1999	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
response to oxygen-containing compound	GO Biological Process Annotations 2015	1.0	null
testis_7b	HPA Tissue Sample Gene Expression Profiles	1.0	1.23529
suramin sodium-7529	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56081
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
corticosterone-1307	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OP-11A-11R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ikzf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	37.9831
CASTOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01382
penbutolol-2972	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GRPEL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96692
metacycline-2901	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PFSK-1	GDSC Cell Line Gene Expression Profiles	1.0	1.79552
smoothmuscle_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
theca interna	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.197637
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KH-01A-21R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K01980291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33717
OBI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86904
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.840963
zimeldine-1512	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
colorectum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057389
TRAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50551
santonin-4531	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.96076
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RBM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78905
GSE173873_10_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CALHM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50505
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05043
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7385-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tiaprofenic acid-2492	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sulfadimidine-3940	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF550	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28461
BRD-K76329122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67671
BRD-K38035271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31106
Lung adenocarcinoma_LUAD_TCGA-44-8117-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DBI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50411
BRD-K33787033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74946
TAF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79062
CACNA2D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36247
meglumine-5285	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.261284
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BT483	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.919656
BRD-K47212522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56972
BRD-K72934808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07581
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K97067262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17624
496100438_PCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.36532
SHP77	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39217
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73P-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6046
BRD-K11823863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61614
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2816-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.835
intrinsic component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
abnormal pituitary secretion	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K40923781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30272
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4154
Liver hepatocellular carcinoma_LIHC_TCGA-BD-A2L6-11A-21R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AN3-CA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZXDB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3922
USP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73945
mania	GWASdb SNP-Phenotype Associations	1.0	0.514254
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12321
sulfachlorpyridazine-3769	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IL11RA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52129
H3K4me1_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
APBB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85569
H3K9me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.21956
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.19228
DorsalRootGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.04557
Class A/1 (Rhodopsin-like receptors)	Reactome Pathways 2024	1.0	null
GSE127790_13_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K57356416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23869
ANKZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55118
Prestwick-682-6638	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82454
ZKSCAN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6917
BRD-K66841501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76122
NCIH2887	DepMap CRISPR Gene Dependency	1.0	6.53736
Prostate adenocarcinoma_PRAD_TCGA-EJ-7328-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12872_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K52123140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25314
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-BrtoFay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GNAI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70501
solasodine-3924	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K75007044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01179
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.921736
postnatal	GeneRIF Biological Term Annotations	1.0	null
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF502	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79533
CRCGN016_MCF10A.TP53.M_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.60468
H3K27me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27me3_erythroblast_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53612668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13481
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Ensembl_ID_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
quinidine-6267	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.702
acetylsalicylic acid-1204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K93126086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20977
GSE239747_2_v_3_lrp6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7961
DA-40-HO94_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.235075
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-ESRRA_ESRRA	Rummagene Transcription Factor Associations 2026	1.0	null
HS698T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70087
striatum_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15432
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72229
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sulfachlorpyridazine-4326	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HSFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88967
SKBR3	CCLE Cell Line Gene CNV Profiles	1.0	2.09062
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19073
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SERPINB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89918
tenoxicam-4102	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04158
OVSAHO	CCLE Cell Line Gene Expression Profiles	1.0	1.38136
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE183413_0_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
Opioid abuse	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
RARA-24833708-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K79067166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15628
FURIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65833
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6222-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
RGPD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6701
oxymetazoline-2114	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
quinethazone-4529	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF215	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13381
PRECLH	CCLE Cell Line Gene Expression Profiles	1.0	1.59062
[125I]Y-RFRP-3	DGIdb Drug Targets 2026	1.0	2.78589
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
METTL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64549
1DMe	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
temporal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.86437
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.844
sitosterol-7332	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.01782
BRD-K22789469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42417
MYCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95495
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.94865
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.52007
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.32906
SNU423	DepMap CRISPR Gene Dependency	1.0	3.38005
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fludroxycortide-2184	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RBM26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54489
CRCGN011_HEPG2_24H:I20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.136
dropropizine-7429	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KE39	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
CTCF_MCF-7_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH660	CCLE Cell Line Gene CNV Profiles	1.0	1.70505
monensin-3704	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
IGDCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41634
SDCBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11762
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5207
ZBTB47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02828
TSPAN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21391
BRD-K18600476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39297
salivarygland	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.24614
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.04557
hematological neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.195518
CRCGN015_MCF10A.WT.HP_24H:P17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10446
STK26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17161
Limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.24
USP33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.97911
BRD-K37271110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0596
Pain	DisGeNET Gene-Phenotype Associations	1.0	null
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32983
isoconazole-5857	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PTDSS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85252
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
oculomotor nuclear complex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.917912
CLEC2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77429
BRD-K75426080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71902
Bed nucleus of stria terminalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.706
GSE137144_5_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30704
496100619_HIP_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.2716
alpha-estradiol-1635	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18494
BRD-A36774080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68287
VPS9D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75877
PTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87933
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_5_CXCL10-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K01951210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1658
TP53INP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50587
GLIS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72783
BRD-K60052521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66994
chlorcyclizine-6053	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
rostral subdivision of medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.95157
sulfaphenazole-1673	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NKTR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3035
COS-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.752
Corpus luteum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.772
clozapine-4670	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE142232,GSE142234_0_v_2_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RBM18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60138
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HN	GDSC Cell Line Gene Expression Profiles	1.0	1.41775
SOCS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13741
BRD-K01995700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88218
monorden-6178	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
5707885-6438	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
altizide-4491	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
days	GeneRIF Biological Term Annotations	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.02556
HMCES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89816
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
EZH2_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.913899
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cotinine-4650	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A5KG-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE172016_2_v_0_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBCEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85879
Mature ovarian follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.718
TEAD4	ChEA Transcription Factor Targets	1.0	null
BRD-K60772078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02766
GSE220520_1_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral hypothalamic area, tuberal region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.42299
GSE74528_0_v_1_trex2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SIX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08422
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.267871
Brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.263
phentolamine-3779	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Plastid membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.321
Prestwick-1082-3530	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ectoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.122709
ONS76	CCLE Cell Line Gene Expression Profiles	1.0	1.64894
g-protein coupled peptide receptor activity	GO Molecular Function Annotations 2015	1.0	null
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056414
FLI1-21867929-TH2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.323075
Lung squamous cell carcinoma_LUSC_TCGA-85-7710-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PCED1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70995
NAXD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30545
spinal cord	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68709
ZNF236	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39232
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.901548
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bronchus	HPA Tissue Protein Expression Profiles	1.0	2.36209
BRD-K10181552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65283
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.25675
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.12301
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05362
etamivan-1730	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE253056_0_v_1_erythropoietin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cortico-medial group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.69458
H3K27me3_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
IOSE80	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.82839
moxisylyte-1682	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_1311_KO_Cntnap4_SRP386887	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.04991
REXO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60818
RYK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87796
methacholine chloride-5773	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
clebopride-5412	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pancreatic alpha cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.123
CTCFL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1107
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2981-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KNS81	DepMap CRISPR Gene Dependency	1.0	3.95469
ribavirin-6018	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.818
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2258
2,6-dimethylpiperidine-6049	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Supplementary_Figure_15l-FOSL2_ChIP_WT-exclusive_genes_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
PHPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79858
Brain Lower Grade Glioma_LGG_TCGA-S9-A89V-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
median nucleus of thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.019
BRD-K28753508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1549
5230742-970	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K35132745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78567
SIN3A	ENCODE Transcription Factor Targets	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
LPGAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28703
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.56005
Cerebellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.32
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.96232
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.972994
BRD-K66351990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81292
chlorpromazine-6176	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.765985
A2058	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53707
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BLOC-1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.836
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
dihydroergocristine-7275	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.364615
avian pallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.563238
PNU-0230031-3735	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TMEM81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32751
ADCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63871
GSE199899_1_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
neoplasm	GWASdb SNP-Phenotype Associations	1.0	0.054775
Disorder of sexual development	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
H3K27me3_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K91104058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35323
gabapentin-3472	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
UQCRQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78244
Acute Myeloid Leukemia_LAML_TCGA-AB-2903-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder	GTEx Tissue Gene Expression Profiles 2023	1.0	4.25976
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GANAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22685
C6orf136	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29831
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62746
BRD-K84936524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.443
GSE62843,GSE64371_4_v_0_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K18178356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12849
BRD-K22598343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03149
ZNF610	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44176
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SURF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41019
tacrolimus-284	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
CREBBP	ENCODE Transcription Factor Targets	1.0	null
GPRASP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91158
pindolol-2238	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
methocarbamol-2111	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
UACC-257	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.47408
BRD-K94469522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67475
H3C6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55374
KMM1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37995
FEM1C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21318
PPIP5K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50307
GSE179002_4_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KLF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41124
H3K27me3_erythroblast_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37454185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33103
thiethylperazine-3576	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07615
H2BC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.55219
acepromazine-4494	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Habenular trigone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.641
karakoline-2203	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37831546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40406
hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.377245
cho cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.305361
Peritubular contractile cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.521
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051703
ciclosporin-4411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ISL1-27105846-CHIP-SEQ-CPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
AFDN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46391
Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K76713298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09619
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.539
Gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.928
OVCAR8	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.79037
PNU-0251126-3689	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NEK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85331
GADD45A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72031
SNU626	DepMap CRISPR Gene Dependency	1.0	2.75284
mediodorsal nucleus of thalamus_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.32577
benserazide-6722	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
rolipram-6730	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K46641047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81532
carteolol-4096	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.43791
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68364310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43445
Edinger-Westphal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.49515
HNF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99249
DESI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30613
doxepin-7415	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
fludroxycortide-3679	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16923
dobutamine-3206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
B4GALT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74072
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48778
SLFN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22435
BRD-K09468701	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70146
DNAJC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37844
EW8	CCLE Cell Line Gene Expression Profiles	1.0	2.0081
SUIT2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.54713
PHLDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23461
ITFG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46308
Epididymis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE179002_0_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
rostral subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.955506
homologs	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
icSARS-Cov_Day4_None_GSE50000	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.8295
debrisoquine-3207	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
organ system cancer	GWASdb SNP-Disease Associations	1.0	0.081535
riluzole-4689	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
trichostatin A-2566	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.6691
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.938255
Lung adenocarcinoma_LUAD_TCGA-53-7626-01A-12R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AMOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68714
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5672-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mebendazole-3671	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.791044
H3K27me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.825243
alexidine-3699	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6482-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5954
CRCGN015_HEPG2_48H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.90991
ATP13A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36777
COMPOUND 16A [PMID: 38522114]	DGIdb Drug Targets 2026	1.0	1.39295
Organum vasculosum laminae terminalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.979
GSE62843,GSE64370_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
KRT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40015
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
raloxifene-3480	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.87341
sulfamethoxazole-3667	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
AFG3L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76821
SH2D3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25159
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7049-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4888-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
furaltadone-4313	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158715_3_v_0_cyp1b1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.421
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP5ME	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77994
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76448
PTPRJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6743
PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR	Rummagene Transcription Factor Associations 2026	1.0	null
raubasine-2898	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A253	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49936
BRD-K41684304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.76779
BRD-K66253165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3195
H3K27me3_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.946384
isocorydine-2780	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
sirolimus-5602	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-UE-A6QT-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.865548
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.220321
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.48926
GSE62843,GSE64371_4_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K43936610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27433
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PACSIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76624
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE253041_1_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_H_sapiens_970_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21118
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19354
H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.623359
ASPHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05433
cingulate gyrus, retrosplenial part, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.10969
CHST15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05586
fludrocortisone-282	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K05277255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08844
fusiform gyrus, left, bank of cos	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03221
TSEN54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29179
neuropeptide receptor activity	GO Molecular Function Annotations 2023	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.495701
TIMM44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2015
sulfadimidine-4322	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
raloxifene-5759	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF449	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99048
GSE132948,GSE132949_0_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148514_0_v_1_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
glipizide-1508	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
adenohypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.864312
HNF4	MotifMap Predicted Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A62S-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31942
piracetam-1710	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SJRH30	GDSC Cell Line Gene Expression Profiles	-1.0	-2.10137
TSPAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97914
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.879094
HEC-1-A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.847
DVL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52389
TNFSF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58907
Adrenocortical carcinoma_ACC_TCGA-OR-A5JO-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5939
GSE241701_4_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.29228
red nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.987472
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8637-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF774	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5808
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.151
PPP6R3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28427
Brain Lower Grade Glioma_LGG_TCGA-DU-5851-01A-13R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
neuroepithelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.478145
BRD-K41732846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28913
TMEM70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.678
trichostatin A-1535	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.499
Brain Lower Grade Glioma_LGG_TCGA-HT-7874-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
neuroepithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.184236
CTCF_H1-hESC_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
well	GeneRIF Biological Term Annotations	1.0	null
kawain-2337	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.898394
Avian pallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.82
FTSJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.06946
tropicamide-2309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
3-hydroxy-DL-kynurenine-1300	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GABARAPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2442
WARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09196
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-EGR1_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate-macrophage	Tabula Sapiens Gene-Cell Associations	1.0	1.36918
LYRM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89123
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20116
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC9160255-41467_2022_30710_MOESM5_ESM.xlsx-AR-targeted_enhancer_peaks_anno-GeneExpression_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
gemfibrozil-5488	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
5152487-896	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GET4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27982
TMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3159
cotinine-1511	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DNASE1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56096
BRD-K28559679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01623
hematologic cancer	GWASdb SNP-Disease Associations	1.0	0.235873
TGFBI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66591
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
J-774 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.676
metaraminol-3669	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pentetrazol-2255	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SLC4A11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03133
UO31	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.2557
carbachol-5342	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
arecoline-5423	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K05616059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02391
Prostate adenocarcinoma_PRAD_TCGA-YL-A8HO-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE127790_13_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
equilin-5255	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOMEZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11931
TTC38	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46131
ZNF638	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55007
prochlorperazine-1640	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
alpha-TC1.6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.412
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.34436
primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.18573
erbB-2_OE_GDS1925_164_human_Estrogen receptor (ER) alpha positive MCF-7 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
viomycin-7036	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CEBPB-20513432-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
lynestrenol-6756	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DX-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
thioridazine-4454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	205.127
BRD-K47200630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05524
fluvoxamine-4114	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K49907349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10395
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.095928
tretinoin-5767	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Arcuate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.03
Proximal dendrite	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.879
DACH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10298
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCIMY7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32125
isotretinoin-6017	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43891
etilefrine-4415	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Anterior hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.708
496100501_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.52562
SW780	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46407
FUNDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05659
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
lovastatin-2494	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PSMD9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11357
clotrimazole-5726	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9767
diethylstilbestrol-4547	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lymphoblastic leukemia	GWASdb SNP-Disease Associations	1.0	0.472092
dihydroergocristine-2895	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ethosuximide-2116	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-4072-01B-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
asiaticoside-2943	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
BRD-K86677819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32939
ALDH4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61881
Prestwick-857-3355	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ANKRD13C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55664
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.928041
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH650	DepMap CRISPR Gene Dependency	1.0	4.37552
tyloxapol-6452	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GPCR downstream signalling	Reactome Pathways 2024	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
thiamazole-3898	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VPS33B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03458
leukemia	GWASdb SNP-Disease Associations	1.0	0.413127
GSE62843,GSE64370_0_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05357297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04689
G protein-coupled peptide receptor activity	GO Molecular Function Annotations 2025	1.0	null
Hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.979
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
Optic lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.389
SW1116	CCLE Cell Line Gene Expression Profiles	1.0	1.44223
Raphe nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.182
UQCRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47548
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49490091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48085
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98084
rostral presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44108
thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.019
AIDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34547
CTNNA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30397
Sexual health disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
PTPN18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29775
0317956-0000-3969	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.64024
BRD-K03935681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26287
nordihydroguaiaretic acid-524	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
5707885-6433	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-7714-01A-12R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Theca cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.402
Calcium	HMDB Metabolites of Enzymes	1.0	null
YH13	CCLE Cell Line Gene CNV Profiles	-1.0	-1.8179
Withdrawal disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.708
OVOL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42741
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23377
CRCGN008_HEPG2_24H:I12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94325
BRD-K22537050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05752
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10003
ZNF33A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19421
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19H-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K25878187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46119
ACKR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31968
GSE196104,GSE196106_2_v_0_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
vinburnine-2781	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
acenocoumarol-5878	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LEPROTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95306
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.37205
RRBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98689
Lung squamous cell carcinoma_LUSC_TCGA-66-2755-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
isradipine-6347	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10312
fenbendazole-4542	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE127790_10_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ethionamide-4418	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.406
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Unnamed_4_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
triflupromazine-1691	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A71722688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30388
CPEB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78045
BRD-K77518191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78343
calcium folinate-2579	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE253041_3_v_0_ramp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ONCODG1	CCLE Cell Line Gene CNV Profiles	1.0	2.71581
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.33326
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.875555
communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.22692
GATD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62177
cell body	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.270068
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.958826
NCIH2052	CCLE Cell Line Gene Expression Profiles	-1.0	-2.40153
ampicillin-1530	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
polymorphic layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32625
MED13L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47573
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051928
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40157
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.31596
CRCGN012_HEPG2_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44696
CEBPB-20176806-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Suprachiasmatic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.545
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.494136
cell part	GO Cellular Component Annotations 2015	1.0	null
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03875
droperidol-5690	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
quipazine-2782	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NR0B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40142
brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.791044
LXF-289	GDSC Cell Line Gene Expression Profiles	-1.0	-1.66578
POMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42073
GSE143955_1_v_0_ripk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100574_HIP_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02194
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
phenformin-3725	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.832186
bendroflumethiazide-2555	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RPUSD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13238
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25506
496100388_HIP_probable Alzheimer's disease_no TBI_87_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22671
PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Figure_4f-FOSL2_ChIP_WT-exclusive_genes_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
FAM117A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42889
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.042
HTR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68669
lymphoblastic leukemia	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.052255
NEUROPEPTIDE FF	DGIdb Drug Targets 2026	1.0	1.39295
GSE221955_3_v_2_igfbp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Midbrain central gray	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.003
iopromide-4504	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5741-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GRINA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37062
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.940061
trimetazidine-5479	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98794
LPS510	DepMap CRISPR Gene Dependency	1.0	3.25984
fulvestrant-6197	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pontine raphe nucleus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.27451
foliosidine-2201	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
2,6-dimethylpiperidine-4363	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Eye-muller cell	Tabula Sapiens Gene-Cell Associations	1.0	5.36192
FOXP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90057
BRD-K37865854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1009
probucol-3223	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.78042
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.1322
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PA-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE139427_2_v_1_ibrutinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
metolazone-5392	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Hypogonadism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.063
22RV1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2757-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
naphazoline-1466	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dexibuprofen-6471	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CDKN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43257
NFRKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44868
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38288
SREBF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3009
pilocarpine-5341	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.46001
Liver-liver dendritic cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.109617
torasemide-5476	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10312
fulvestrant-4462	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K44643967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5067
synaptic transmission	GO Biological Process Annotations 2015	1.0	null
cingulate gyrus, parietal part, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09984
MHHNB11	CCLE Cell Line Gene Expression Profiles	1.0	1.50206
isoconazole-2056	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.094723
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62072978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14846
letrozole-7336	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FRAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64051
TK10	BioGPS Cell Line Gene Expression Profiles	1.0	1.15295
epididymis	HPA Tissue Protein Expression Profiles	1.0	2.36209
fenbufen-3721	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC2998	DepMap CRISPR Gene Dependency	1.0	3.9117
nordihydroguaiaretic acid-6182	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K62909525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23949
NCI-H1781	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.836131
BEN	GDSC Cell Line Gene Expression Profiles	-1.0	-1.65273
Sarcoma_SARC_TCGA-DX-AB2Z-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1215
CBP-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K25165359	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56227
KLHL25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62255
midecamycin-5345	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A47416464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17061
H3K9me3_Peripheral Blood Mononuclear Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
TM31	CCLE Cell Line Gene Expression Profiles	-1.0	-2.05356
Signaling by GPCR	Reactome Pathways 2014	1.0	null
STAT3-24763339-IMN-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE95685_6_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
fat_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
GI-1	GDSC Cell Line Gene Expression Profiles	1.0	1.53557
CRCGN015_HEPG2_48H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.63094
lung_3f	HPA Tissue Sample Gene Expression Profiles	1.0	0.904959
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14973
COX6C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14066
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
orbital frontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.48159
FLI1-21867929-CD8-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K59587063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21325
CRCGN015_HEPG2_48H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29205
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
TRMT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.2267
BRD-K56253099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14105
Whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
JEG-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
flumetasone-4734	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PCCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40136
convolamine-2771	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Mesothelioma_MESO_TCGA-TS-A7OY-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Female germ cell nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.924
F0447-0125-6396	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Median nucleus of thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.172
inner CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04576
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.11525
COMPOUND 8B [PMID: 38522114]	DGIdb Drug Targets 2026	1.0	1.39295
male	GeneRIF Biological Term Annotations	1.0	null
NCBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13596
BRD-K88934376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00494
Rectum adenocarcinoma_READ_TCGA-AF-4110-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20J-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33855
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
VANGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48183
single organism signaling	GO Biological Process Annotations 2015	1.0	null
ventral tegmental area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46526
Prestwick-1100-3798	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cilium	GO Cellular Component Annotations 2023	1.0	null
cancer	GWASdb SNP-Disease Associations	1.0	0.07519
DCAKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12397
alpha-estradiol-2670	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cefazolin-4708	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EW-24	GDSC Cell Line Gene Expression Profiles	-1.0	-2.6346
PMC4524600__F6	PFOCR Pathway Figure Associations 2024	1.0	null
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.26491
stachydrine-2743	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.01987
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
MEG01	CCLE Cell Line Gene CNV Profiles	-1.0	-2.00176
NCIH716	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
Amygdala	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.817
CTCF_GM12872_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ketoprofen-3729	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-A4XH-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE139992_1_v_0_mboat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HEATR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21724
SR-95531-4236	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
oxedrine-6156	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHCHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96897
Bladder Urothelial Carcinoma_BLCA_TCGA-HQ-A2OF-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77425312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04005
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05192
HECA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26637
cyclobenzaprine-1332	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
G alpha (q) signalling events	Reactome Pathways 2014	1.0	null
STK17B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16897
INPPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6858
GSE148692,GSE148695_5_v_4_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TOR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45469
BRD-K78615842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27791
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4469
Nucleus taeniae	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
BRD-K24711162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13741
chlorcyclizine-4367	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
streptomycin-3195	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
midbrain reticular formation	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22973
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GLTP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40744
BRD-A42433574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25826
ZNF746	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15254
netilmicin-6005	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tetracycline-5757	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
physostigmine-5749	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.224913
(-)-MK-801-3081	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SU-DHL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34097
CRCGN015_HEPG2_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.61972
epitiostanol-2922	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
convolamine-5876	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pepstatin-1328	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K56716645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04495
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CCNDBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47305
capsaicin-5673	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDM5B	ChEA Transcription Factor Targets	1.0	null
Ventral globus pallidus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.066
DCP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22866
CORO1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75024
RIPPLY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06532
CBX2	ENCODE Transcription Factor Targets	1.0	null
LRRFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61744
Kidney Chromophobe_KICH_TCGA-KL-8336-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
loperamide-5632	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pheneticillin-2542	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
K029AX	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39865
BRD-K36099605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36387
GSE210885_5_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
superior occipital gyrus, left, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06068
BRD-K93716900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33273
CREB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94741
BRD-K64353626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00822
pd5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.803
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.6586
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
breast	HPA Tissue Protein Expression Profiles	-1.0	-1.11895
RGL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78106
etofenamate-2907	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7849
testis_7d	HPA Tissue Sample Gene Expression Profiles	1.0	1.13284
BRD-K73149920	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20077
GSE127790_6_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ciprofibrate-3561	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF454	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	125.336
BRD-A00776891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12338
dacarbazine-2754	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
propafenone-2871	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IWS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85855
zona incerta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.624658
CLPTM1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30391
Tic complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.41
HCC2157	CCLE Cell Line Gene CNV Profiles	1.0	2.7982
HCC1359	CCLE Cell Line Gene CNV Profiles	1.0	1.39588
INA6	DepMap CRISPR Gene Dependency	1.0	2.04221
UCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92284
DDIT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85491
PCM6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.75976
enalapril-2397	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Y-RFRP-3	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Zona incerta	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.56
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OSR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13754
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.267871
BRD-K82521348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04892
TXK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41886
MT-ATP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84965
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4787-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78252315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26136
BRD-A71962374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36202
BRD-K34447537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42384
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.703
ACC3	BioGPS Cell Line Gene Expression Profiles	1.0	1.06063
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.373698
NUP54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37704
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.66979
GSE173873_10_v_6_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45833502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2168
PTPN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05964
globose nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.928138
CTAGE6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9923
Tanycyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.188
USP48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.54569
G protein-coupled receptor, rhodopsin-like	InterPro Predicted Protein Domain Annotations	1.0	null
Polycystic ovary syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
alpha-yohimbine-6274	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.036642
GGA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96437
ANG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04961
pirenperone-2455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1151
ZNF521	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81436
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gonadotrophic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.002
CRCGN017_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91311
TCP10L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26109
ifenprodil-2372	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Dorsal hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.9
MEST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44312
Prostate adenocarcinoma_PRAD_TCGA-HC-8258-11A-01R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MKN-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16659
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4304
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.86629
tropicamide-3722	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
chloramphenicol-5466	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NUP35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31839
CTSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13223
theobromine-6613	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Anxiety disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
sulfamethoxazole-2335	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
glycocholic acid-2454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
butacaine-5748	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.958826
POC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51569
H3K4me1_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A148-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A26343863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18377
SOX4	MotifMap Predicted Transcription Factor Targets	1.0	null
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24692
MITF	ChEA Transcription Factor Targets	1.0	null
H3K27me3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
stria terminalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.311507
Interstitial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.416
Usp22_DEPLETION_GDS4973_284_mouse_E14 embryonic stem cells (ESCs)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
OVMANA	CCLE Cell Line Gene Expression Profiles	1.0	2.03564
GSE200673,GSE200691_1_v_0_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
rosiglitazone-5593	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	83.8167
HMEL	CCLE Cell Line Gene Expression Profiles	1.0	3.40794
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.505
Luteal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.898
SEC14L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06658
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.230382
maprotiline-6676	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pituitary gland tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.733
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05761
SP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.71978
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
EGI-1	GDSC Cell Line Gene Expression Profiles	1.0	1.82333
Anterior lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.212
G protein-coupled receptor activity	GO Molecular Function Annotations 2023	1.0	null
ARPP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30207
mediodorsal nucleus of thalamus_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.57549
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.445
EIF4E2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98274
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	87.598
SNCG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21307
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
inner CP in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.825437
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83225
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.958826
BRD-K53046137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08234
OLIG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34111
C1QBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01492
Spermatid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.59
GSE173873_5_v_11_stra8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EI-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AJUBA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21144
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21856
CRCGN014_HEPG2_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42369
DRGX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42145
Habenula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.576
FEZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.1698
ZFAND4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78681
H3K4me3_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cephaeline-3290	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-SI-A71P-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35081
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PI4K2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70991
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.854939
lateral medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.959212
PMC5637904-PATH-243-193-s015.xlsx-human_down_in_ductal_SOX11-Unnamed_7_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23204014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16782
SF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7969
BRD-K62318087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2591
ZNF304	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74218
ZNF613	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6479
fulvestrant-2665	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me1_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTF2F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2033
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19034
lateral tuberal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.321
THEM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88385
protoveratrine A-2800	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.317
TRIM46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14136
Infundibulum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.45
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
rostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.913342
H3K4me1_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-5393-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H2-01A-12R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lung	HPA Tissue Protein Expression Profiles	-1.0	-1.66732
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-10q22_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K84478344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14575
GSE127790_11_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Nucleus preopticus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.174
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
procaine-5430	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
melatonin-5393	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NP5	DepMap CRISPR Gene Dependency	1.0	3.40476
NUSAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80935
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ISG15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9801
Lung squamous cell carcinoma_LUSC_TCGA-22-4609-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905105
Adrenocortical carcinoma_ACC_TCGA-OR-A5KO-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lateral ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.315861
BRD-K12925598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.67364
SLC39A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.40268
BRD-K58333451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.39604
ALMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21399
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cefmetazole-6086	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
acepromazine-6832	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE111035,GSE111040_8_v_12_plag1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Somatic spine	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.982
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GM-06B-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
oxyphenbutazone-3582	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Metencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.32
SETDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28233
HASPIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68982
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.564
CERS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49463
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23064
response to peptide	GO Biological Process Annotations 2015	1.0	null
BRD-K77221985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00665
WM983B	DepMap CRISPR Gene Dependency	1.0	3.75327
GSE140997_4_v_5_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZFYVE16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34811
specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.968761
LGALS3BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87177
PSMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48432
PK-45H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.901488
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.11931
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K62427254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30981
TMEM200B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36752
BRD-K40418847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61785
RORB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.81535
valproic acid-23	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
testis_7e	HPA Tissue Sample Gene Expression Profiles	1.0	1.02966
H3K27me3_Brain Germinal Matrix	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CTCF_cardiac muscle cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
parolfactory gyri, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.53064
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.958826
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.219707
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pentoxifylline-2127	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
yohimbine-2755	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SOX6-21985497-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE159678_4_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USP31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33971
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11186
DMS-53	GDSC Cell Line Gene Expression Profiles	-1.0	-2.20418
griseofulvin-7363	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
heart	GTEx Tissue Gene Expression Profiles	-1.0	-0.972021
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.61
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23327
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.893756
NCIH841	DepMap CRISPR Gene Dependency	1.0	3.01875
acetylsalicylic acid-6964	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.697
doxycycline-3479	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CBX2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of leukocytes	GWASdb SNP-Phenotype Associations	1.0	0.121887
SVIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17533
etofylline-5467	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF805	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01826
ZNF707	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.5229
PHYKPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79277
bephenium hydroxynaphthoate-4668	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K84062787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74028
cyproterone-4470	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bipolar affective disorder	GWASdb SNP-Phenotype Associations	1.0	0.514254
SLC37A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82539
BRD-K34158806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00563
TERT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31731
Liver hepatocellular carcinoma_LIHC_TCGA-K7-A5RG-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OTULINL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77083
BRD-K37145632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17749
BRD-K45508763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58077
BRD-K50210179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53963
BRD-K92524823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26195
GTF2IRD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.92205
response to endogenous stimulus	GO Biological Process Annotations 2015	1.0	null
BRD-K52335877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47976
hypogonadotropism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.36291
ovary	HPA Tissue Protein Expression Profiles	-1.0	-1.66732
BRD-K22608982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26602
tiletamine-6013	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K39192716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1362
NAA16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61464
ceforanide-3309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K09583061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2697
RFRP-3	DGIdb Drug Targets 2026	1.0	1.39295
BRD-K27543887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10334
GSE126345_0_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
acetylsalicylic acid-2664	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
neuroepithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.190038
FOXC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9445
H3K27me3_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.16763
CTBP2	ENCODE Transcription Factor Targets	1.0	null
NPLOC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50372
FOSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4719
SPINDOC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78715
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.720345
Circumventricular organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.284
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HS863T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55408
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062552
Brain Lower Grade Glioma_LGG_TCGA-HT-7694-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX2-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
abducens nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28748
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16659
apomorphine-5283	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K63864310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35091
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10U-11A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.92316
membrane part	GO Cellular Component Annotations 2015	1.0	null
CFPAC1	CCLE Cell Line Gene Expression Profiles	1.0	1.60375
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3323-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
phensuximide-3521	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43654
outer plexiform zone in extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12641
46,XY sex reversal 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.8938
CARMIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05381
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.958826
IER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35403
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.38285
DUS4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59294
NQO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29608
Acute Myeloid Leukemia_LAML_TCGA-AB-2992-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-7309-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.089318
Diagonal band	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.425
UXT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36213
CRCGN015_HEPG2_48H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.28361
SLC39A7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03733
ME-180	COSMIC Cell Line Gene CNV Profiles	1.0	3.12177
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.052255
lingual gyrus, right, peristriate	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.823984
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ZNF600	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.50583
spectinomycin-3327	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.224558
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
moroxydine-1527	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
aminohippuric acid-6453	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SAR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.113
pheniramine-4012	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE159678_4_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MZT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74508
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
metencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.810221
BRD-K54272776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57479
piriform cortex, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13328
emetine-2801	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
pioglitazone-5977	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HARA	CCLE Cell Line Gene Expression Profiles	1.0	1.54363
endometriosis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.410161
INTS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0479
CRCGN015_MCF10A_48H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.8571
PF-00875133-00-5923	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NDUFAF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51049
apramycin-2914	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K31589685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5614
ACAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36519
GSE129389_0_v_6_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K29298614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40727
Pituitary gland tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.866
PMC7029484-13041_2020_561_MOESM3_ESM.xlsx-Table_S8-Table_S8_The_extracted_upregulated_genes_in_SBMA-MNs_in_GSEA_AR	Rummagene Transcription Factor Associations 2026	1.0	null
SUPT11	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42624
HMY1	DepMap CRISPR Gene Dependency	1.0	2.35355
Paraventricular nucleus of hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.842
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DUSP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08819
spleen	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.32136
EW-13	GDSC Cell Line Gene Expression Profiles	1.0	1.64853
demeclocycline-2545	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
BRD-K01071579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55842
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885766
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.3565
Lung adenocarcinoma_LUAD_TCGA-97-8172-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOXB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5376
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4861-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.71785
GSE198380_0_v_1_phgdh_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C14orf119	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46615
HUPT3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32788
TBP	ENCODE Transcription Factor Targets	1.0	null
betulin-7454	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
azacyclonol-1520	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K83966071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14707
SWAP70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35813
GSE62843,GSE64370_4_v_1_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cefapirin-6790	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
B3GNT8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56531
EFR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53318
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GT1-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.406
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3136
PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_G_gallus_1347_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
TARDBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60271
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00384
PRPSAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4474
FKBP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82367
BRD-K92399035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92539
ketorolac-7286	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AP-3 adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.566
Nucleus preopticus medialis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.858
indometacin-2377	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
Vomeronasal organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.76
CACO2	CCLE Cell Line Gene CNV Profiles	1.0	1.68866
HT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.30616
ZNF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33804
Respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neuronal cell body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.835
CRCGN014_HEPG2_24H:I18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19094
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258777
GSE107505_3_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-8106-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.78782
H3K27me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28471
SYNGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42307
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.061
BRD-K65107903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04745
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ATP5PF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46193
g-protein coupled receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-73-7498-01A-12R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.454
Median eminence	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.521
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.99695
Orexin and neuropeptides FF and QRFP bind to their respective receptors	Reactome Pathways 2024	1.0	null
pentetrazol-2092	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8161-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70632
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K22534934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08091
nerve	GTEx Tissue Gene Expression Profiles	1.0	1.59955
PBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61513
bone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054009
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.42037
UBE2D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17068
UBTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79492
KRT18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22966
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88355
VPS13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53843
estradiol-6200	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
fusaric acid-1308	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K14309706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21653
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
fluorometholone-5771	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K70979181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16574
BRD-K28510065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16196
BRD-K18070214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70538
3-acetamidocoumarin-4601	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lateral tuberal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.819
CTNNBIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31484
ACHN	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.69439
etidronic acid-2985	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
loracarbef-3532	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PRSS27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07224
cellular process	GO Biological Process Annotations 2015	1.0	null
kidney disease	GWASdb SNP-Disease Associations	1.0	0.835629
EFWSLAAPQRF-NH<sub>2</sub>	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
THP1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.31776
CRCGN015_HEPG2_48H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.5117
chrysin-6485	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Nucleus accumbens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.248
carbimazole-2437	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE143955_1_v_2_ripk1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5270-01A-02R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.09914
ependymocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.399492
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44772
chlorphenesin-2279	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
transmembrane signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TW-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH1915	CCLE Cell Line Gene CNV Profiles	1.0	1.92713
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K28140029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03151
signaling	GO Biological Process Annotations 2015	1.0	null
gh1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.538
TMEM42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14858
GSE131887_5_v_2_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HS746T	CCLE Cell Line Gene CNV Profiles	1.0	1.56335
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
suprachiasmatic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.579216
OCUG1	DepMap CRISPR Gene Dependency	1.0	2.80288
haloperidol-7003	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2A1-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K43548664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28307
ACOT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40562
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14575
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LB-11A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
heliotrine-3717	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K22246901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13075
GAREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7601
ZFAND2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.36448
RSPRY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65604
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XM-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	147.731
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.93759
BRD-K45909830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14098
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.730213
Prostate adenocarcinoma_PRAD_TCGA-EJ-5502-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neurosecretory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.945
increased follicle stimulating hormone level	MGI Mouse Phenotype Associations 2023	1.0	null
Uterine fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
CP-690334-01-3906	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRC2_SUZ12_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
BRD-K63277230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81938
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RUNX2-22187159-PCA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Peptide ligand-binding receptors	Reactome Pathways 2014	1.0	null
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RL-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GK-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SR-95639A-1336	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YTHDF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62651
moroxydine-6705	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZIC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86119
EZH2_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
lithocholic acid-3899	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K52731672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43259
dropropizine-2398	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K82145108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14822
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6646
tiapride-7362	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-EU-5905-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.99586
H3K27me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.985463
HS578T	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.20932
gonadotrophic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.86642
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSK3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45151
PC3	CCLE Cell Line Gene CNV Profiles	1.0	1.83784
amiprilose-4000	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
KYSE-450	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ADAMTS16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47517
nicardipine-6297	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TGBC24TKB	GDSC Cell Line Gene Expression Profiles	1.0	1.56668
Brain Lower Grade Glioma_LGG_TCGA-HT-8107-01A-13R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-6136-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
indapamide-3859	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GPCR ligand binding	Reactome Pathways 2014	1.0	null
Inhibin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.604
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K61414850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40199
diethylcarbamazine-2394	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cranial nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.121036
TMEM160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.66574
DNA replication factor A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.571
methotrexate-3214	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF202	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47465
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5249-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CGTHW1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.3212
BRD-K43449580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60375
ISX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81371
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	189.346
proguanil-3505	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CUX1	ChEA Transcription Factor Targets	1.0	null
Class A/1 (Rhodopsin-like receptors)	Reactome Pathways 2014	1.0	null
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
acute lymphocytic leukemia	GWASdb SNP-Disease Associations	1.0	0.986376
superior temporal gyrus, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.96716
metanephrine-6734	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K19501975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09844
gramine-4118	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SEPTIN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9302
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HW-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATAD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84167
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4771-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TNFAIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31252
leflunomide-7238	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
[125I]1DME	DGIdb Drug Targets 2026	1.0	2.78589
AAGAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77462
Vagina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.406
prasterone-6474	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ventrolateral prefrontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03441
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.30466
Recycling endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.749
kaempferol-6157	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
H3K23me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7254-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
methoxamine-6627	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC5637904-PATH-243-193-s015.xlsx-human_down_in_ductal_SOX11-Table_S4C_Downregulated_genes_in_lesions_and_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_the_mammary_duct_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
hydrocotarnine-2765	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.856
NB7	DepMap CRISPR Gene Dependency	1.0	3.59947
GSE255432_4_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
TOV21G	CCLE Cell Line Gene CNV Profiles	1.0	1.33011
Sarcoma_SARC_TCGA-SI-AA8C-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IBTK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18986
AC262970	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-K7-AAU7-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFM19	CCLE Cell Line Gene CNV Profiles	1.0	1.7445
ethisterone-3864	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HMBS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13285
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.66155
thioridazine-417	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
iobenguane-7299	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
neuroactive ligand receptor interaction	KEGG Pathways	1.0	null
Prestwick-920-6497	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42238
BCL7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58
placenta	HPA Tissue Protein Expression Profiles	-1.0	-0.938923
cilium	GO Cellular Component Annotations 2025	1.0	null
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-7823-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K39844985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73684
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.446
SP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06892
Nucleus preopticus periventricularis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.376
UPF3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86941
Mesothelioma_MESO_TCGA-TS-A7P0-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K21232462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18608
H3K27me3_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.052255
GSE185163_5_v_1_clic4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23902
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.54769
BRD-K23203419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0841
cellular response to hormone stimulus	GO Biological Process Annotations 2015	1.0	null
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE126345_7_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.982095
NSUN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02265
DLX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5559
Pancreatic adenocarcinoma_PAAD_TCGA-F2-A8YN-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hematologic cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.052255
GSE148252_5_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
AC262970	DGIdb Drug Targets 2026	1.0	2.78589
enoxacin-4655	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
co-dergocrine mesilate-4071	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nordihydroguaiaretic acid-2683	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
THOP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12682
fenoprofen-2553	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_Adult Liver	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PARN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72239
FAM136A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19352
Hyperprolactinemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
POLR2J2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14048
Reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ANGEL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56338
basophil	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.649344
neuroblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.260606
Narcolepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-SYMBOL_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
AM-38	GDSC Cell Line Gene Expression Profiles	1.0	2.77265
glibenclamide-5849	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K69347147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.44445
BRD-K56161792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.217
LIM1215	COSMIC Cell Line Gene Mutation Profiles	1.0	null
lymphoid leukemia	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.052255
Psychosexual disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.171
H3K9me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.995054
Neurohypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.345
E2F6	ENCODE Transcription Factor Targets	1.0	null
TCF12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.0978
midodrine-6804	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
levonorgestrel-3406	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Secondary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.87
ENTREP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31733
nipecotic acid-6500	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
probucol-4666	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lynestrenol-1537	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
20161705-Table2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K95860374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74238
SPI1	ENCODE Transcription Factor Targets	1.0	null
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
BRD-K77221872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13397
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KHNYN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66276
em2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.349
amikacin-3233	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K60600704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3264
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16754
POLG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68588
Mesocorticolimbic dopaminergic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.826
Prestwick-674-3716	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NB13	DepMap CRISPR Gene Dependency	1.0	8.73424
BRD-K87537204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01656
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16659
tinidazole-4370	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PNPLA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48006
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NL-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43159427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23172
Prestwick-1080-3796	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prestwick-1103-6019	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Immature ovarian follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.614
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.900383
OGDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35072
sulmazole-4009	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
laterodorsal thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.233162
ABCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73351
BRD-K37515001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47303
posterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.895753
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.78995
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30196
alcuronium chloride-7345	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CARD19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49425
hexetidine-5420	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TRAPPC6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08408
urapidil-6455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FCGRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91104
striatum_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.0365
agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.25776
MFSD14A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41678
ASNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11926
pheniramine-4130	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
betaxolol-3208	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48778
PANCREATIC POLYPEPTIDE	DGIdb Drug Targets 2026	1.0	1.39295
butyl hydroxybenzoate-4647	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Pars tuberalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.57
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
BRD-K39460811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31613
carbimazole-5399	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
paclitaxel-1542	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A87C-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20657
CACNG7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01472
enilconazole-5538	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN009_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.50081
RABGEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90801
valproic acid-6181	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Chloroplast inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.406
AG-013608-6435	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
estrone-3071	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TGFBRAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75663
DNAJC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0572
CCK81	DepMap CRISPR Gene Dependency	1.0	3.83495
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EJ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HT	CCLE Cell Line Gene CNV Profiles	1.0	2.23011
18318837-TableS2	GeneSigDB Published Gene Signatures	1.0	null
P300-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MAVS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43109
ALYREF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23172
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.75532
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
calcium pantothenate-4189	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AH-23848-6885	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
medial subdivision of area 10	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.40704
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.875644
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059016
DFFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7804
TXNDC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80986
TMEM200C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25824
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05168
neuroepithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.187141
BRD-K68665079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73462
ronidazole-3557	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Alzheimer Disease	HuGE Navigator Gene-Phenotype Associations	1.0	null
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.76595
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.25365
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
bone cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070942
MXI1	ENCODE Transcription Factor Targets	1.0	null
AMO1	DepMap CRISPR Gene Dependency	1.0	2.91673
BRD-K72770355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20754
Signal Transduction	Reactome Pathways 2014	1.0	null
GSE95685_2_v_5_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
prednisolone-2393	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CEBPZOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45379
MTHFD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24669
Lung squamous cell carcinoma_LUSC_TCGA-92-7340-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56837922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36359
BRD-A82976259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09634
response to hormone	GO Biological Process Annotations 2015	1.0	null
BRD-K60744874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09243
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8403
BRD-K07460436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27266
MFE280	CCLE Cell Line Gene Expression Profiles	1.0	1.87818
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
BRD-K78866450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73195
doxylamine-4235	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1428	CCLE Cell Line Gene CNV Profiles	1.0	1.49934
sulconazole-3373	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CDK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33675
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
oxaprozin-4352	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
meynert's basal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.610138
DNAJC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97685
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Drug dependence	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.0577
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.6473
troglitazone-4456	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46128
pancuronium bromide-4393	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.693
bendroflumethiazide-3415	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRPH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61085
trimethoprim-3678	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PTCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91041
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
molecular transducer activity	GO Molecular Function Annotations 2015	1.0	null
GSE179002_0_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KDM5B-21448134-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
ALVA31	BioGPS Cell Line Gene Expression Profiles	1.0	1.271
salsolidin-4226	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE62843,GSE64371_2_v_5_furan_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17917
CTCF_GM12871_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BIBP3226	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.739266
CRCGN017_MCF10A.TP53.M_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.1063
CP-320650-01-4560	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K41433616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37689
PHA-00745360-4559	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CDC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.66043
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.97592
granulocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.195792
disease of cellular proliferation	GWASdb SNP-Disease Associations	1.0	0.073338
Ovarian follicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.752
hycanthone-3229	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A78982410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59765
PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2710-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_medulloblastoma_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055774
TMEM9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28271
BRD-K52383401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15756
trichostatin A-2450	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K07981644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43174
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
ursolic acid-2230	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZFP42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.50094
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220975
osteosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075121
SYNE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83122
lynestrenol-2037	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K9me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
LbetaT2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.044
PNKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53877
YD8	DepMap CRISPR Gene Dependency	1.0	2.46459
H3K27me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMCHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95653
BRD-K59049340	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28621
BRD-K27221973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16982
OXNAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09164
PPARG-20176806-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36492
IFIH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36832
monastrol-668	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RF9	DGIdb Drug Targets 2026	1.0	1.39295
Appendix	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.23928
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
increased neuron number	MGI Mouse Phenotype Associations 2023	1.0	null
AKAP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98222
chlorpromazine-4441	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Gastrin-CREB signalling pathway via PKC and MAPK	Reactome Pathways 2014	1.0	null
METTL22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5937
CHTF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47092
GSE126345_2_v_3_hcrt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K15393664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2957
BRD-K22957824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53769
H3K4me1_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A5RB-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GP1BA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40299
496100539_HIP_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.98174
CRCGN010_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.48998
CASKIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.69487
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A905-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RDX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56506
GW-8510-7067	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pentolonium-3676	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K67096761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46691
MXRA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72865
CRCGN015_HEPG2_48H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.19483
etamsylate-7335	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K28029070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24623
GSE149035_7_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.086
AC262620	DGIdb Drug Targets 2026	1.0	2.78589
GNG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76613
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GPAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30707
mood disorder	GWASdb SNP-Disease Associations	1.0	0.303164
GATA3-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
sirolimus-1632	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC5637904-PATH-243-193-s016.xlsx-human_down_in_fat_SOX11-Table_S5C_Downregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
piroxicam-2089	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KDF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0425
troglitazone-1657	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
iopromide-6842	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K97949309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27283
CRCGN015_HEPG2_48H:J17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.58237
STAT5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94546
BRD-K91895574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37165
etifenin-2838	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K59747214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37981
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.159658
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.538
Tegmentum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.437
H3K4me1_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC9160255-41467_2022_30710_MOESM5_ESM.xlsx-AR-targeted_enhancer_peaks_anno-ENSEMBL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K37019305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01558
paromomycin-3017	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hydroxyzine-1524	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36678
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47922
H4C14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28202
BRD-K09615275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04088
alvespimycin-6973	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN011_HEPG2_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03645
ZFP69B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.34106
meteneprost-7500	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.887247
rescinnamine-2785	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trigeminal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.165416
glafenine-2387	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K65888165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96816
CA46	COSMIC Cell Line Gene Mutation Profiles	1.0	null
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04642
NHERF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2348
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Chloroplast membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.361
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.95971
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.867066
enoxacin-5251	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.957769
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.056199
nih 3T3	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.48555
propafenone-1722	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
flecainide-2557	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
5279552-960	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.033129
cerebral gray matter	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.186247
subgenual (subcallosal) division of MFC (area 25)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12578
cellular response to organic substance	GO Biological Process Annotations 2023	1.0	null
chlorcyclizine-3893	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Epididymal epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.035
CINP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22656
CRCGN017_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89116
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LZIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33725
H3K9me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K69011607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67747
H3K27me3_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76680796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06609
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	108.632
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47756
BRD-K44622259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66294
Eye-limbal stromal cell	Tabula Sapiens Gene-Cell Associations	1.0	1.07342
BRD-K87602457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71625
BRD-K61595867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29621
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
immune system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores	1.0	0.052255
S100A6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77469
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8271
[<sup>3</sup>H]NPVF	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
WM115	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67515
HDAC2	ENCODE Transcription Factor Targets	1.0	null
KLHL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87587
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33984
GSE191021_1_v_0_nono_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SOX18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59313
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054544
GSE112860_9_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Seminiferous tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.539
CRX-20693478-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ketotifen-5842	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
oxolamine-3006	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCIH1963	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62822
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19375
BRD-K19534880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13874
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.965242
ZIC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73269
C1QL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21239
GSE112763,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88654
BRD-K01360791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22111
trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.441042
SKRC20	DepMap CRISPR Gene Dependency	1.0	5.07125
tridihexethyl-3526	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K66559139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19222
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.457
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8319
bemegride-3051	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RAB1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37325
PF-01378883-00-6410	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HT	DepMap CRISPR Gene Dependency	1.0	2.41415
Perturb_5360_KO_Tcf12_SRP392331	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.40202
BRD-K58270905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26274
CRCGN014_HEPG2_3H:F09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04771
BRD-K76706127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7044
superior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03248
prilocaine-2352	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
iproniazid-6359	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SOX9-22984422-TESTIS-RAT	ChEA Transcription Factor Binding Site Profiles	1.0	null
SUCLG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.71339
MMP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.10742
ciprofibrate-6218	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
harpagoside-7355	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-01A-31R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fluvoxamine-2913	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pheniramine-1492	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K95761590	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27262
TOMM34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92826
SNU213	CCLE Cell Line Gene Expression Profiles	-1.0	-1.70736
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.58653
UBR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09696
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.898394
epithelioma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.478145
selegiline-2465	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRCA1_DN.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K01067435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23112
ZIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0904
BRD-K20009653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34623
FKBP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8555
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.925799
amide binding	GO Molecular Function Annotations 2015	1.0	null
TCF7L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58384
lymphnode_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.32992
NUS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56068
PATZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60777
galantamine-2787	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
46,XY sex reversal	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
butyl hydroxybenzoate-5608	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
liver	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.1857
procainamide-4602	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.19296
KATNBL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37009
hesperetin-1531	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	104.026
Periventricular nucleus of hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.308
D341MED	CCLE Cell Line Gene Expression Profiles	1.0	1.4704
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16659
PMC9160255-41467_2022_30710_MOESM5_ESM.xlsx-AR-targeted_enhancer_peaks_anno-SYMBOL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ATL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36774
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4704
propylthiouracil-4076	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MARVELD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50877
16-phenyltetranorprostaglandin E2-7509	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF517	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48981
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
PEBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61506
ELP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.04682
HCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854512
NDUFS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27036
tranexamic acid-5762	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
atractyloside-3695	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ozagrel-2942	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861825
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64599
azaperone-5877	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
velnacrine-3292	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
skimmianine-5766	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SLR23	CCLE Cell Line Gene Expression Profiles	1.0	1.47328
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1PU-01A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bambuterol-3199	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.5674
Prostate adenocarcinoma_PRAD_TCGA-HC-7079-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UROD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66679
cerebellar cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00574
Lung squamous cell carcinoma_LUSC_TCGA-77-A5FZ-01A-31R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200235
GSE182680,GSE182683_0_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZRANB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.14437
PMC7997806-41397_2020_194_MOESM2_ESM.xlsx-MAGMA_GENE_SBP_AA-GENE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
YY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25131
H3K27me3_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gpr147	GeneRIF Biological Term Annotations	1.0	null
BRD-K15863674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03122
H3K4me1_Fetal Lung	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CAL78	CCLE Cell Line Gene Expression Profiles	-1.0	-1.87207
Granulosa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.612
DKMG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80998
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Gene_name_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A47137250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06257
Brain Lower Grade Glioma_LGG_TCGA-DU-7298-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07836769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32079
SALE	CCLE Cell Line Gene Expression Profiles	1.0	2.65485
GSS	DepMap CRISPR Gene Dependency	1.0	2.56866
dorsolateral prefrontal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.876697
nalbuphine-1379	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27103
sulfamethoxypyridazine-4733	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MITD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33951
BRD-K55187504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27434
methyldopate-2940	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.25
tolnaftate-1501	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MTREX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1884
CREBBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140997_4_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LIG4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68769
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052792
LEF1-29337183-MESC-MOUSE-STEM	ChEA Transcription Factor Targets 2022	1.0	null
RUNX2	ChEA Transcription Factor Targets	1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05738
H3K27me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
biological regulation	GO Biological Process Annotations 2015	1.0	null
Germ cell nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.891
KAT6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59639
tranylcypromine-5996	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
INO80B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74285
SAP30	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5011-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GH3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.811
SRCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54436
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K67426191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58234
GABRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88644
valproic acid-5206	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bromperidol-2872	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
trimethadione-4165	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51754677	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86312
dorsolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.44564
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.78088
Orexin receptor pathway	WikiPathways Pathways 2024	1.0	null
pridinol-2715	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-EV-5901-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
corbadrine-2710	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FBXO7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67931
Brain Lower Grade Glioma_LGG_TCGA-FG-5962-01B-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46637
cerebellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.814397
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01585
NASP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28812
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.67442
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.489057
decreased luteinizing hormone level	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K86774687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32036
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.14055
H4K20me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
chr10_70277511_C_G_b38	GTEx eQTL 2025	1.0	1.45049
cetirizine-4815	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
signal transduction	GO Biological Process Annotations 2015	1.0	null
ATAD2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51082
HCC1897	CCLE Cell Line Gene Expression Profiles	1.0	1.34807
ARMCX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06714
BRD-K66434795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51095
CTCF_GM12866_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
amphotericin B-3303	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TC32	CCLE Cell Line Gene Expression Profiles	1.0	2.40869
GSE137144_4_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_ID_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null