association dataset threshold value standardized value OCUB-M Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.26212 PMC11651170-pt4c00533_si_002.pdf-56-GRHL1_GRHL1 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CORL23 Achilles Cell Line Gene Essentiality Profiles 1.0 1.05681 Ventral posterolateral nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16875 lateral part of CoP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29073 SK-MM-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null SYK_druginhibition_290_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.99505 GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15028 GSE184902_4_v_1_adiponectin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE201270,GSE201272_5_v_1_mybl2_human RummaGEO Gene Perturbation Signatures 1.0 null Imago TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.518 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXP1_FOXP1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.23105 organelle GO Cellular Component Annotations 2015 1.0 null SUMO-targeted ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.75 GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.70503 amygdaloid complex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10751 H3K4me1_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null intermediate stratum of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48333 TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01558 CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.87447 Nfe2l2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 21.489 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.854983 LMO2-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles 1.0 2.0102 MAN1B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31605 H2AK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47662 outer SZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.897681 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.990816 H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_17431_KO_Tcf7_SRP096345 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 PB-18-HD85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.33621 intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null RUNX1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC12522211-NIHMS2104691-supplement-MMC1.xlsx-SRCAP_DE_genes-Gene_SRCAP Rummagene Transcription Factor Associations 2026 1.0 null VAX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.0201 RD-92-QT24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.375848 QE-18-WG07_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.280613 organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05376 intermediate stratum of TSPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11435 GSE199255,GSE199356_3_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null STAT6 ChEA Transcription Factor Targets 1.0 null IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.521255 GSE103068_0_v_1_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.51047 Ventral posteromedial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54472 TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.64727 KARPAS-1106P COSMIC Cell Line Gene Mutation Profiles 1.0 null SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.15191 SYK_druginhibition_281_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.62215 GTEX-O5YT-1326-SM-3MJGR GTEx Tissue Sample Gene Expression Profiles 1.0 1.58414 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MET_knockout_259_GSE25583 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.5184 CD-35-BD44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.336758 Lysosomal HOPS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.209 GLIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.0053 terminal subparaventricular area of THyA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29484 H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84406 prostate GTEx Tissue Gene Expression Profiles 1.0 1.24002 fallopiantube_8c HPA Tissue Sample Gene Expression Profiles 1.0 1.24609 smc1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.725 NCIH1623 CCLE Cell Line Gene Expression Profiles -1.0 -2.16393 dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.8228 inner SZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00827 Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE213228_1_v_3_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.61837 SMC6 Pathway Commons Protein-Protein Interactions 1.0 null GSE231641_0_v_1_robo1_mouse RummaGEO Gene Perturbation Signatures 1.0 null superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.30294 primary visual cortex (striate cortex, area V1/17)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01077 CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 3537_GRINA_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.854695 CREB1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE133763_0_v_1_chd1_human RummaGEO Gene Perturbation Signatures -1.0 null TCF7-22412390-EML-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null OB-71-IZ36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.224339 MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06587 SW 948 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25341 viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null JB-14-TF61_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.301556 GTEX-RVPV-1226-SM-2TF73 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23275 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.39973 A549_Sorafenib Tosylate_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0159353 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B6-01A-21R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACHN Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.0595 intermediate stratum of DTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59901 BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.361733 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE71468,GSE76476_0_v_3_rbfox1_human RummaGEO Gene Perturbation Signatures -1.0 null periventricular stratum of TPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43644 GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979667 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE111035,GSE111040_10_v_9_plag1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01217 H3K4me1_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0011-R11A-SM-4AT5J GTEx Tissue Sample Gene Expression Profiles -1.0 -2.37665 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-A5DJ-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null double-strand break repair via homologous recombination GO Biological Process Annotations 2025 1.0 null hMPV_72Hour_18234263_GSE8961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.20374 GTEX-XQ3S-2526-SM-4BOOG GTEx Tissue Sample Gene Expression Profiles 1.0 1.22936 RUNX1_KO_GDS1511_251_mouse_Embryos at E12 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-UTHO-0011-R5A-SM-3GIJD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898153 GTEX-WFON-2326-SM-3LK7M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.867427 IRF2 JASPAR Predicted Transcription Factor Targets 1.0 null PK-45H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02109 CDX2-20551321-CACO-2-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OOBJ-0008-SM-3NB26 GTEx Tissue Sample Gene Expression Profiles 1.0 1.33845 E2F1-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null mantle zone of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1532 GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -2.33556 pparb_23093780_pancreas_lof_mouse_gpl1261_gds4320 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.161323 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 primary motor cortex (area M1, area 4)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.924912 Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7454_RPL27A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.56412 REST_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4P0-01A-41R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cytoplasmic periphery of the nuclear pore complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.452 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LN-18 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.63751 SPI1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EIF3H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02872 periventricular stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01142 fat_a.V1 HPA Tissue Sample Gene Expression Profiles -1.0 -1.08017 GTEX-WFG8-0126-SM-4LVMH GTEx Tissue Sample Gene Expression Profiles 1.0 1.04188 cytoplasm GO Cellular Component Annotations 2015 1.0 null SUMOylation of DNA damage response and repair proteins Reactome Pathways 2024 1.0 null PMC7260947-pnas.1912355117.sd02.xlsx-Sheet1-1185_common_genes_in_D_E_genes_KD_and_AcAPE1_ACOGG1_G4_AR Rummagene Transcription Factor Associations 2026 1.0 null medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.69653 GSE211177,GSE211178_9_v_11_ets1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE125782_0_v_2_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null YY1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prp19 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.019 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41364 POU2F2_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.982942 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.11575 Perturb_6791_KD_CDK12_SRP042402 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.60205 GTEX-X4EP-0326-SM-3P5Z6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.836657 GSE102132_2_v_1_irf3_human RummaGEO Gene Perturbation Signatures 1.0 null SARS-ddORF6_60Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.40948 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE100316_3_v_1_mtor_mouse RummaGEO Gene Perturbation Signatures 1.0 null Pons BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.872168 H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VUSG-0126-SM-4KL1X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49069 GSE112761,GSE112767_4_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null YF-00-IN39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.336111 GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 1.53461 POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null nucleoplasm GO Cellular Component Annotations 2015 1.0 null GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.919231 GTEX-NL4W-0008-SM-4E3I2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.951269 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-3026-SM-3DB76 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.836147 mammillary body, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.824166 primary motor cortex (area M1, area 4)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.34742 GTEX-XQ8I-1926-SM-4BOOK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.834827 GSE199204,GSE211619_4_v_6_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE235066_4_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null MMP24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1682 K562_MK-5108_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0204845 organelle part LOCATE Curated Protein Localization Annotations 1.0 null Pyramus (VIII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05865 GSE203308_14_v_5_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 7455_RPL27_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.87838 NCIH1793 CCLE Cell Line Gene Expression Profiles -1.0 -3.33617 Hypothalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.866 GSE211177,GSE211178_8_v_3_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Megalencephalic leukoencephalopathy with subcortical cysts DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.481 GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 1.79252 GSE231648_1_v_5_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null regulation of telomere maintenance GO Biological Process Annotations 2025 1.0 null A549_TMP195_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148056 substantianigra BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.11094 ACHN CCLE Cell Line Gene CNV Profiles 1.0 1.4943 GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27601 outer SZ in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22737 ATN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07661 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1 JASPAR Predicted Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A4JB-01A-51R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUDUL1 CCLE Cell Line Gene Expression Profiles 1.0 1.89607 superficial gray layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56921 GSE135400_1_v_0_kdm1b_human RummaGEO Gene Perturbation Signatures 1.0 null GSE128054_1_v_0_myt1_human RummaGEO Gene Perturbation Signatures -1.0 null RAD21_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral part of MM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42837 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44595 GTEX-QXCU-0006-SM-2TC5K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45464 PML body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.224 CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51968 PMC7244323-elife-55325-supp3.xlsx-This_paper_TP53-KO-Gene_TP53 Rummagene Transcription Factor Associations 2026 1.0 null GSE147876,GSE147877_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OOBK-0726-SM-3LK5Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.951811 GSE220058,GSE220059_0_v_1_prrc2b_human RummaGEO Gene Perturbation Signatures 1.0 null medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.21307 MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.27915 Polycystic kidney disease 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.393 WDR37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.73091 cerebellar cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.53795 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-RP-A6K9-06A-41R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BB-40-KK84_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.246317 Pyramus (VIII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04474 septopallidal part of the olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09525 WE-43-PZ45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.219237 CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null XPO5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14354 sirolimus_homo sapiens_gpl2895_gse16944 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.51047 NCIH196 CCLE Cell Line Gene CNV Profiles -1.0 -1.35408 1538_CFLAR_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.546266 RNF182 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38815 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JF-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 10029_ZC3H8_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.516406 NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.39672 SA-31-VB03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.390695 CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null alar part of terminal hypothalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26503 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26475 GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74125 TE6 CCLE Cell Line Gene Expression Profiles -1.0 -1.8069 MINO CCLE Cell Line Gene Expression Profiles 1.0 1.45756 Liver hepatocellular carcinoma_LIHC_TCGA-ES-A2HT-01A-12R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 KB-78-BE93_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.328597 mantle zone of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.84271 Brain Lower Grade Glioma_LGG_TCGA-RY-A83Z-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.36419 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null striatum_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03396 signal transduction GO Biological Process Annotations 2015 1.0 null 496100378_TCx_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.57002 9667_USP4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.848376 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB7A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OS-RC-2 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.07916 Respiratory allergy DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.052 SP2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.850423 SP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.79925 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 2.55792 SYK_druginhibition_282_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.75412 EC-86-EK93_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.495503 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE237040_6_v_1_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null GSE162739_7_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-V1D1-0008-SM-4JBIJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.825593 GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles 1.0 2.74248 MYC_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.949152 JD-62-HR05_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.224647 SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.31954 H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RAD21 ENCODE Transcription Factor Targets 1.0 null AA-99-HO76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.253163 496100436_FWM_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.23063 artery TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null RAD21_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ABCA1_OE_GDS2303_189_mouse_LDL receptor-deficient livers GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null VZ in caudal cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1011 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Smc5-Smc6 complex GO Cellular Component Annotations 2023 1.0 null Paracentral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73475 VCAP Achilles Cell Line Gene Essentiality Profiles -1.0 -1.05347 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.0189 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MALME3M CCLE Cell Line Gene CNV Profiles -1.0 -1.78909 GTEX-OHPM-0726-SM-3LK7A GTEx Tissue Sample Gene Expression Profiles 1.0 1.24834 CA-68-KG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.62194 primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.967084 aminoacyl-tRNA synthetase multienzyme complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.81 pancreas TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858844 MET_knockout_250_GDS3148 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.70869 MB-53-WO35_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.236506 protein complex GO Cellular Component Annotations 2015 1.0 null Colonic epithelium cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.53 ventrolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.89548 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33738 GSE184884_2_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.47945 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Lung adenocarcinoma_LUAD_TCGA-67-3772-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 2543_EIF2S3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.533414 Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE163809_1_v_2_sdhaf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 3.23625 GSE248769_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null FC-13-VS25_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.0181 H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null GTEX-VUSG-1526-SM-4KKZH GTEx Tissue Sample Gene Expression Profiles 1.0 0.850908 GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75397 GSE178714_3_v_4_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null ATF1 ENCODE Transcription Factor Targets 1.0 null ID-12-NA84_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.277269 LA-42-ER00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.92062 MDAMB361 CCLE Cell Line Gene CNV Profiles 1.0 1.44058 MCF7_Thiotepa_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015366 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XQ3S-1726-SM-4BOOD GTEx Tissue Sample Gene Expression Profiles 1.0 1.13877 PANC0813 Achilles Cell Line Gene Essentiality Profiles -1.0 -2.31017 GSE203308_15_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CEBPB_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1168 basal part of terminal hypothalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18135 GSE110178_1_v_7_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null CENP-A recruiting complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.601 Prostate adenocarcinoma_PRAD_TCGA-J4-A67M-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.874622 GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52983 H3K4me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE149901_3_v_1_anlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-SIU7-0426-SM-2XCDX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22578 ND-15-RC31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.246579 DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.12722 AML193 Achilles Cell Line Gene Essentiality Profiles 1.0 1.42958 GSE205316,GSE205317_0_v_3_nrip1_mouse RummaGEO Gene Perturbation Signatures 1.0 null superficial stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83565 MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r9 part of nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.22303 GTEX-RWS6-2126-SM-2XCAV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53918 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE178714_3_v_2_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE157282_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28342 ZBTB7A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMRM-0526-SM-2I5GA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.922166 GATA1 ENCODE Transcription Factor Targets 1.0 null CB-24-AT90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.239803 H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A8BK-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24802 amygdaloid complex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.850423 GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.83591 RO82-W-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.04527 PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4-22529382-TROPHECTODERM-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE230263,GSE230265_0_v_1_runx1_human RummaGEO Gene Perturbation Signatures -1.0 null ESR1 ChEA Transcription Factor Targets 1.0 null GSE191105_2_v_3_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r10 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.87348 LMO2 ChEA Transcription Factor Targets 1.0 null TE11_OESOPHAGUS CCLE Cell Line Proteomics 1.0 2.2095 PMC8190596-mmc2.xlsx-RUNX1_mut-RUNX1_mut_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.4211 GSE181966_0_v_3_has2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Malignant Neoplasm DisGeNET Gene-Disease Associations 1.0 null ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE137144_3_v_0_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null increased circulating triglyceride level MGI Mouse Phenotype Associations 2023 1.0 null PD-70-VS77_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.274114 ZE-45-CG69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.59319 GSE156923_2_v_1_rbmx_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BE-27-XF09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.309385 Basolateral amygdalar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04948 tonsil_8a1 HPA Tissue Sample Gene Expression Profiles 1.0 1.2189 intracellular organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-VJYA-0001-SM-3NMDJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.933318 SHOC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29819 PMC8200296-LSA-2020-00928_TableS2.xlsx-table_s2_DEGs_log2foldchange_0-Table_S2_List_of_DEGs_induced_by_YY1_knockdown_YY1 Rummagene Transcription Factor Associations 2026 1.0 null EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PBX1-22567123-OVCAR3-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE210885_2_v_4_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null HD-51-KD29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.04756 KCI-MOH1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08668 H3K4me1_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null H3K9ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33315 FOXO3-22982991-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null LTBR_INHIBITION - 3 Days_GDS2005_730_mouse_Lymph nodes (MG-430B) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE164874_5_v_3_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-SJXC-0526-SM-2XCFG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34728 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-208b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 ESR1-22446102-UTERUS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.892187 COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922271 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null FAM117A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33734 SETDB1-19884257-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HCC202 CCLE Cell Line Gene Expression Profiles 1.0 1.95339 POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12073 H4K91ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null JHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.28913 GSE207582_2_v_1_testosterone_mouse RummaGEO Drug Perturbation Signatures 1.0 null 5828_NSMCE1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.584167 GTEX-T5JC-0011-R11A-SM-32PMB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.876872 EF-74-KW12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.88739 GSE217071_3_v_0_ythdf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31915 OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25341 AC-74-ZA35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.304356 CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Tazemetostat_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0136762 ventral juxtacommissural pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16938 GSE134375_0_v_7_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null GSE120612_7_v_1_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null BCLAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_SB431542_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172548 ELK4 ENCODE Transcription Factor Targets 1.0 null GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.957419 TAL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-TSE9-0526-SM-3DB7Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84529 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null protein modification by small protein conjugation GO Biological Process Annotations 2023 1.0 null lateral mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.88915 GATA1_G1E-ER4_mm9_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_astrocyte of the cerebellum_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180277_0_v_1_bach2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC9399107-41467_2022_32627_MOESM6_ESM.xlsx-20_T-cell_subsets-gene_name_CD8_C1_LEF1_LEF1 Rummagene Transcription Factor Associations 2026 1.0 null Sarcoma_SARC_TCGA-DX-A3UD-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-0926-SM-4DM4Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.826363 BB-11-JI42_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.424908 GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.70931 H3K27ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-O1-A52J-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFATC1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15783 H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PRDM14-20953172-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null cerebellar cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.59574 cation binding GO Molecular Function Annotations 2015 1.0 null magnocellular interstitial nucleus of the posterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42977 H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Basolateral amygdalar nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21548 GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47456 H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TMZS-0001-SM-3P61Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.833581 YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KNS-42 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.81193 M-1 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.890701 head of caudate Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.855231 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.8355 MCF7_Meprednisone_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0150797 H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF687 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14285 mediodorsal nucleus of thalamus_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00107 nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 recombinational repair GO Biological Process Annotations 2023 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.926176 non-membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null GTEX-REY6-0726-SM-2TF4M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11147 Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WO-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SARS-CoV MA15_Day7-PFU-10^5_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.61434 Flemming body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.56 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 1.66453 PMC12077394-giaf035_giga-d-24-00380_revision_2.pdf-15-HMG20B_HMG20B Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SNOS-1526-SM-32PLW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60346 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -7.96222 jm2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.539 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ion binding GO Molecular Function Annotations 2015 1.0 null TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP2 ENCODE Transcription Factor Targets 1.0 null GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.897762 Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.07447 POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null double-strand break repair GO Biological Process Annotations 2025 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null Adult_Liver Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.829562 Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M9-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7476_RPL6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.766329 PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR Rummagene Transcription Factor Associations 2026 1.0 null MOLM16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 3.09532 GSE147876,GSE147877_4_v_7_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XGQ4-0326-SM-4GIEE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.953896 protein modification by small protein conjugation or removal GO Biological Process Annotations 2015 1.0 null CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_8912_KO_NUDT21_SRP323081 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.46944 H3K27ac_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DA-10-HD17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.292572 PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_unique_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null GSE103003_1_v_0_zeb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null b220.bcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.27111 TOLEDO CCLE Cell Line Gene Expression Profiles 1.0 2.19143 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A654-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GSE258991_5_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.315 GSE138019_3_v_2_nudt12_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE211177,GSE211178_4_v_3_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5881-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE75976_3_v_4_abl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE109140_0_v_3_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null anterior pretectal nucleus, dorsal core part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00636 nucleus COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48666 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_1day-MOI-10^4_None_GSE44441 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.64386 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.74489 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer V of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27805 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Subrhabdomeral cisterna COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.325 POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC3507642-1471-2164-13-355-S4.xlsx-direct_AR-repression_Cmpd30-UP-HUGO_AR Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL-85-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.827013 nuclear part LOCATE Curated Protein Localization Annotations 1.0 null cell part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-S7SF-0426-SM-3K2B7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.953113 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE144443_0_v_1_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE146612_1_v_3_amiodarone_human RummaGEO Drug Perturbation Signatures -1.0 null PMC8490503-thnov11p9519s3.xlsx-Proteins_High_MLL-Gene_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.863082 NCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null transferase activity GO Molecular Function Annotations 2015 1.0 null MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BB-79-AG41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.249364 TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26884 GATA3 JASPAR Predicted Transcription Factor Targets 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.90445 GSE48812_4_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null Skin-mast cell Tabula Sapiens Gene-Cell Associations 1.0 0.370473 GSE163862_2_v_3_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.62054 olfactory part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.879561 7453_RPL26_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.557661 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TMMY-0005-SM-33HBN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14509 POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CC-48-OM48_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.298 ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 103.077 POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35853 Testis BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.98082 GSE220600_1_v_2_clpp_mouse RummaGEO Gene Perturbation Signatures -1.0 null CC-48-OM48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.205694 GSE118794_2_v_4_zmynd8_mouse RummaGEO Gene Perturbation Signatures 1.0 null IRF3 ENCODE Transcription Factor Targets 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H1-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1569 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.826051 EP300_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-0126-SM-3NB1E GTEx Tissue Sample Gene Expression Profiles 1.0 1.14458 GSE161842_1_v_2_kdm6b_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.00148 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K9ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 3677_HEATR1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.535147 FF-86-NH56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.550206 CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.966136 COLO818 CCLE Cell Line Gene Expression Profiles -1.0 -1.66947 COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13202 HOP-62 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.40027 HCC1954 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.03552 GTEX-REY6-0005-SM-2TF54 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.992008 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VCPKMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.69946 Weight Loss CTD Gene-Disease Associations 1.0 1.36961 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IH-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LA-42-ER00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.81161 FOXO3 ChEA Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4488-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null chromosome, telomeric region GO Cellular Component Annotations 2015 1.0 null Perturb_8504_KO_Hr_SRP200420 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.43126 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.01127 primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.06111 GSE120370_4_v_1_thrombin_mouse RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE160817_3_v_6_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null LNCAP Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.95234 GSE140074_1_v_0_kif20a_human RummaGEO Gene Perturbation Signatures 1.0 null intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 substantia nigra, pars reticulata, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.29745 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebralcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.127 PC-62-AQ92_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230152 POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-BatSRBD_48Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.43635 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.990816 BB-79-AG41_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.236679 Lung adenocarcinoma_LUAD_TCGA-55-8096-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD19+_BCells(neg._sel.) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.12598 CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.23939 primary auditory cortex (core)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.67486 TMUB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14891 SKMEL5_SKIN CCLE Cell Line Proteomics 1.0 2.09176 GSE208350_0_v_1_fgfr1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null reticular formation of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43981 chromosome, telomeric region COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 VZ in subcallosal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3513 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein modification by small protein conjugation GO Biological Process Annotations 2015 1.0 null GSE178714_6_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null lateral TG part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65764 BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4505-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA Rummagene Transcription Factor Associations 2026 1.0 null GTEX-O5YT-0726-SM-3MJHA GTEx Tissue Sample Gene Expression Profiles 1.0 1.13354 POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4EP-0526-SM-3P5YW GTEx Tissue Sample Gene Expression Profiles 1.0 0.931315 Nucleus COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.965 GSE186810,GSE186813_3_v_1_furin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OHPK-0326-SM-2HMJO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.873551 10478_ZNF585A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.639134 CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217115_2_v_5_alectinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE162739_6_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Artery disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.742 posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.846356 BA-39-OX47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.297891 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null behavioral abnormality GWASdb SNP-Phenotype Associations 1.0 0.11129 MutSgamma complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.625 occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.61094 5089_NIFK_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.539227 K562_AICAR_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161752 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nucleoplasmic periphery of the nuclear pore complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.462 GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05635 Lung adenocarcinoma_LUAD_TCGA-05-4395-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_12713_KD_KMT2D_SRP062172 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.7417 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null positive regulation of cellular process GO Biological Process Annotations 2015 1.0 null 7451_RPL24_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.508281 GSE149264,GSE149267_4_v_1_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null 7437_RPL13_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.558914 BCL3 ENCODE Transcription Factor Targets 1.0 null CEBPD_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Costunolide_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0142442 IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.676418 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYB-26560356-CHIP-SEQ-TH2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE57871_1_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_5047_KO_SYTL3_ERP126655 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CBX3_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ERBB3_drugactivation_31_GDS4361 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.69199 intermediate stratum of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42317 intracellular membrane-bounded organelle GO Cellular Component Annotations 2023 1.0 null QE-18-WG07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.27723 NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.82405 MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Droxinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0224906 MDAMB231_BREAST CCLE Cell Line Proteomics 1.0 2.63159 ALG11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23109 CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Condensed chromosome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner SZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50704 CAL33 CCLE Cell Line Gene CNV Profiles 1.0 1.34439 periventricular stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.71326 YD-49-HM53_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.28101 binding GO Molecular Function Annotations 2015 1.0 null GAS2L3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24347 JUND-26020271-SMOOTH-MUSCLE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.37486 HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.5394 FBXL19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67747 FA-80-DR66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.411369 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7466_RPL36_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.705283 SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.804342 HuP-T3 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.42177 Slx1-Slx4 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.504 H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular signal transduction GO Biological Process Annotations 2015 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2986-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DD-75-HY40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.16107 GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.923083 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49226 NR2F2 ENCODE Transcription Factor Targets 1.0 null GSE210655_1_v_4_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE184892_4_v_1_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.62207 GTEX-OOBK-2025-SM-3LK5S GTEx Tissue Sample Gene Expression Profiles 1.0 0.852669 GTEX-WFG8-2426-SM-3GILL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965198 C-33-A COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-Q2AI-1226-SM-48U14 GTEx Tissue Sample Gene Expression Profiles 1.0 2.00791 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null DPAGT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08943 RCC-MF COSMIC Cell Line Gene Mutation Profiles 1.0 null organic cyclic compound metabolic process GO Biological Process Annotations 2015 1.0 null fetus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE142210_9_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null GSE172295_0_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ME-31-RM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.457998 LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34617 Lung squamous cell carcinoma_LUSC_TCGA-66-2782-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPB_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KM-12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.953052 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LR-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sin3a_22783022_mcf7_lof_human_gpl570_gds4388 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.014239 GTEX-V1D1-2426-SM-3GAER GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02235 GSE60691_2_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null AC-84-QG99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.468826 CBX3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Non-structural maintenance of chromosomes element 1 InterPro Predicted Protein Domain Annotations 1.0 null MSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.9173 Sarcoma_SARC_TCGA-DX-A7ET-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF217-24962896-MCF7-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null yy1_22711985_skeletal_muscle_lof_mouse_gpl8321_gse39009 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.667957 r6 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40274 positive regulation of response to dna damage stimulus GO Biological Process Annotations 2015 1.0 null REST_PFSK-1_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Asthma, allergic_Lung Tissue_GSE3184 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.96383 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 RELA_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.1605 abnormal spleen morphology MGI Mouse Phenotype Associations 2023 1.0 null H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5548 A549_MC1568_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0167015 GTEX-PX3G-0326-SM-2I3EO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898694 GABPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5722 POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.16235 CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31692 TMEM151A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79973 hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.3742 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRF3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null S1PR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35939 REL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.2941 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SIU7-1826-SM-2XCE2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.960893 GTEX-QEG5-1226-SM-447AR GTEx Tissue Sample Gene Expression Profiles 1.0 0.954922 A549_Lomustine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140381 macromolecule modification GO Biological Process Annotations 2015 1.0 null PJA1 Pathway Commons Protein-Protein Interactions 1.0 null intermediate stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55531 Turner Syndrome_CNS - Brain (MMHCC)_GSE1606 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.67082 GSE113106_0_v_4_dnm2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.0297 abnormal uterus morphology MGI Mouse Phenotype Associations 2023 1.0 null CD56+_NKCells BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.824171 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BICR 31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06469 GSE149075_6_v_5_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-WRHK-1626-SM-3MJFH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49884 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SW480 Achilles Cell Line Gene Essentiality Profiles 1.0 1.34176 H3K9ac_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null WC-59-RG09_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.262494 POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein modification process GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-2665-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pallidohypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.991243 CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211177,GSE211178_0_v_11_ets1_mouse RummaGEO Gene Perturbation Signatures -1.0 null JD-58-MV19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.295397 dorsomedial nucleus, terminal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07421 H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.11871 H3K79me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Diabetic Neuropathy_Sciatic Nerve_GSE11343 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.96125 KE-24-RZ94_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.312977 GTEX-X5EB-0626-SM-46MVQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.944191 BCLAF1 ENCODE Transcription Factor Targets 1.0 null GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 2.1068 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HT-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE157296,GSE157298_4_v_3_kbtbd4_human RummaGEO Gene Perturbation Signatures 1.0 null parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.94054 Isolated growth hormone deficiency type IA DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.383 PMC12824706-BLOOD_BLD-2025-028441-mmc3.xlsx-Fig4B_genes_inc_expr_NRF1-gene_name_NRF1 Rummagene Transcription Factor Associations 2026 1.0 null ZBTB7A ENCODE Transcription Factor Targets 1.0 null GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.55606 GTEX-NPJ8-1726-SM-2YUNB GTEx Tissue Sample Gene Expression Profiles 1.0 1.09206 SPI1 ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7163-01A-12R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE233183,GSE233187_3_v_6_larp1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null GSE114690_2_v_3_tnfsf14_mouse RummaGEO Gene Perturbation Signatures -1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.52693 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39488 496100622_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.3476 RPL24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37098 POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-VN-1203-2004(H5N1)_Day2-10^2pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.81333 GSE121824,GSE121826_0_v_3_scaf8_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of m1AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39042 FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17009876-tableS1b GeneSigDB Published Gene Signatures 1.0 null TAF2-19829295-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PQ-1526-SM-3NMCK GTEx Tissue Sample Gene Expression Profiles 1.0 1.1894 GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.60774 PMC5537006__F1 PFOCR Pathway Figure Associations 2024 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.42124 intracellular organelle LOCATE Curated Protein Localization Annotations 1.0 null Perturb_6276_KD_GAS1_SRP050422 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Lung squamous cell carcinoma_LUSC_TCGA-18-3417-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Zfp335 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.1667 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null AA-11-RO46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.307043 GSE188869,GSE188871_2_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null Adenocarcinoma of lung_Lung Tissue_GSE11969 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.65344 CA3 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1153 MVK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41626 increased circulating total protein level IMPC Knockout Mouse Phenotypes 1.0 null GTEX-XGQ4-0526-SM-4AT6C GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935629 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-1726-SM-4DXUP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.992276 CA-31-EL19_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.223727 PMC9336541-Table_3.XLSX-C-vs-H6-L_filter_annot-Unnamed_18_HMX1 Rummagene Transcription Factor Associations 2026 1.0 null GSE125014_1_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null 7507_RPS18_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.565106 superficial stratum of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57491 HEC50B CCLE Cell Line Gene CNV Profiles -1.0 -2.04693 H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc_24Hour_None_GSE43204 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.48902 posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.888065 CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JC-0001-SM-3NMAK GTEx Tissue Sample Gene Expression Profiles 1.0 0.971581 GSE158834_2_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05376 GSE131887_5_v_3_doxycycline_mouse RummaGEO Drug Perturbation Signatures 1.0 null rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.41623 CB-44-RT90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.442697 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.977961 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null DA-33-BM26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.32549 CB-83-LF14_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.214927 KLF3_01_221 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.75608 CORL23 CCLE Cell Line Gene Expression Profiles 1.0 1.5425 Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE112760,GSE112767_2_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null MEWO CCLE Cell Line Gene CNV Profiles -1.0 -2.73626 PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15 Rummagene Transcription Factor Associations 2026 1.0 null DLD-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JAK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08042 UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.51047 MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.934315 perimammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09176 UA-39-TN76_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.232675 GTEX-S95S-0002-SM-3NM8K GTEx Tissue Sample Gene Expression Profiles 1.0 0.9716 MAFK ENCODE Transcription Factor Targets 1.0 null blood TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null 7477_RPL7A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.653798 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-V1D1-0003-SM-3NMDP GTEx Tissue Sample Gene Expression Profiles 1.0 0.974963 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE146982_3_v_1_gpd1_human RummaGEO Gene Perturbation Signatures 1.0 null female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE175787_11_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XMK1-0001-SM-4B64F GTEx Tissue Sample Gene Expression Profiles 1.0 0.825683 GTEX-W5WG-0008-SM-4KL25 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08206 FD-20-OG99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.811124 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null QB-99-OU03_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.242712 GTEX-QLQW-0626-SM-447A6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26533 PBX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EMX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.1525 AE-19-BK71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.334369 GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 1.90689 PMC9601604-NIHMS1841143-supplement-SuppTable-2.xlsx-FOXO3-specific_targets-FOXO3-specific_targets_1218_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null 2988_FBL_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.537605 GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.49421 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_mammary epithelial cell_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE192663_1_v_5_acly_mouse RummaGEO Gene Perturbation Signatures 1.0 null pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.60697 MAF-26560356-CHIP-SEQ-TH2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.531233 GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles 1.0 2.91971 primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.3056 AB-01-NB05_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206179 amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08114 Lung squamous cell carcinoma_LUSC_TCGA-77-8144-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE178714_5_v_2_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null SP2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H2106 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.49372 GSE213588_8_v_4_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE180641_0_v_1_zfp503_mouse RummaGEO Gene Perturbation Signatures 1.0 null HOXC9-25013753-NEUROBLASTOMA BE2-C-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null spinalcordlower BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.04733 H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SNMC-0926-SM-4DM5U GTEx Tissue Sample Gene Expression Profiles 1.0 1.38026 dorsolateral prefrontal cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.56265 BB-20-UU03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.250239 GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles 1.0 2.47689 HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE164463_4_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.8577 7454_RPL27A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.668774 GSE217156_1_v_3_trpc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AKT1_knockout_212_GSE39699 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.41377 GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -2.43091 hESC_Derived_CD56+_Mesoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.32876 H2AFZ ENCODE Transcription Factor Targets 1.0 null Cellular bud neck septin structure COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.637 CC-20-FN31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.270403 H4K91ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PW2O-0226-SM-48TC7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07061 FRS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5715 GTEX-QEG5-0826-SM-2I5GF GTEx Tissue Sample Gene Expression Profiles 1.0 1.16735 H3K79me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intermediate part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16232 SF295 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.17896 EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NDNL2 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE126621,GSE126920_1_v_0_dppa4_mouse RummaGEO Gene Perturbation Signatures 1.0 null EF-92-OO68_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.281188 striatum_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.980086 SP2 ENCODE Transcription Factor Targets 1.0 null EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05376 DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.324345 PMC9574515-mmc1.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WWP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51455 HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null FA-80-DR66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.14393 H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE216043_7_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null SP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.827487 STAT4-19710469-TH1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null organism form TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null C2BBE1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.958045 r10 part of the vestibular column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02843 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KATOIII CCLE Cell Line Gene Expression Profiles -1.0 -2.75468 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.19967 IRF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60349 IFNAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04586 VA-48-RJ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209523 lateral group of nuclei, right, ventral division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.901498 Perturb_4868_KO_NEUROG3_ERP110708 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.53228 5462_NAPA_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.929262 GSE160373_5_v_7_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WFG7-1226-SM-4LMK2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34958 iPS-20b Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.24927 POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part LOCATE Curated Protein Localization Annotations 1.0 null YF-77-FV50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.237294 7441_RPL17_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.949105 GTEX-X585-0011-R11B-SM-46MUZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.924928 LAMB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35801 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7453_RPL26_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.72869 deep gray layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.31235 FU97 CCLE Cell Line Gene CNV Profiles 1.0 1.41637 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null umbilical cord blood TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null LN235 Achilles Cell Line Gene Essentiality Profiles 1.0 1.22864 CREB1 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-MF-A522-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CC-03-PW00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.541668 nucleolus LOCATE Curated Protein Localization Annotations 1.0 null BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SZ in caudal cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.978528 ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null sirolimus_mus musculus_gpl1261_gse5332 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-UTHO-0011-R4A-SM-3GIJP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0772 choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.99047 NCI-H1734 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.61374 H3K56ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null USF1 ENCODE Transcription Factor Targets 1.0 null GTEX-U3ZH-0002-SM-3NMDD GTEx Tissue Sample Gene Expression Profiles 1.0 0.975013 PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_12_GATA1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PVOW-0426-SM-2XCF8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893286 GE-53-SM76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.363209 CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4486-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XXEK-2026-SM-4BRVE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886688 primary auditory cortex (core)_25 pcw_F_12948 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23278 primary motor cortex (area M1, area 4)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.51019 HCC4006 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04735 Gfi1b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.2499 medial mammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44174 POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01973 abnormality of nervous system physiology GWASdb SNP-Phenotype Associations 1.0 0.062811 Synaptonemal complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.85 NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.990816 17660535-TableS4c GeneSigDB Published Gene Signatures 1.0 null TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA3-21878914-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ubiquitin-like protein transferase activity GO Molecular Function Annotations 2015 1.0 null GATA1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10349775-432_2022_4445_MOESM1_ESM.pdf-3-HOXA3_HOXA3 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Fanconi anemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.022 EZH2 ENCODE Transcription Factor Targets 1.0 null GSE188870,GSE188871_4_v_5_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null Posterior complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01983 GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.927881 GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52487 Hepatitis, Autoimmune_Hepatic Tissue_GSE867 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.71138 H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5469-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM1A ENCODE Transcription Factor Targets 1.0 null XY body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.147 Smad4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.243 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null COLO829_SKIN CCLE Cell Line Proteomics 1.0 15.2016 IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.84639 primary motor cortex (area M1, area 4)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.847015 Dsl1/NZR complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.804 commissural pretectal domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07445 CREB1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-1626-SM-2TF5N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52374 GB-06-BA49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.557967 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43S-01A-21R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05526 SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.963774 lymphnode_5b HPA Tissue Sample Gene Expression Profiles 1.0 0.84638 TF1 CCLE Cell Line Gene Expression Profiles -1.0 -1.71414 FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null KMH2 CCLE Cell Line Gene Expression Profiles 1.0 1.36932 Mecom JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.6667 786O Achilles Cell Line Gene Essentiality Profiles 1.0 1.02959 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968306 CEBPD ENCODE Transcription Factor Targets 1.0 null CTCF_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE228413_0_v_3_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null 7525_RPS3_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.652191 single-organism metabolic process GO Biological Process Annotations 2015 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_710_KO_DNMT1_SRP389363 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.71507 GSE203308_1_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE101546_3_v_5_setdb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null RXRA::VDR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.5 GRANTA-519 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.63821 GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 1.52748 Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DC-84-CJ21_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.291487 GTEX-R53T-1826-SM-3GIJX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10462 BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.296461 AC-55-XA97_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.905717 STAT1-20625510-HELA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSK3_INHIBITION_GDS4043_459_human_MLL leukemia cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE169356_2_v_4_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RVPV-0226-SM-2TF6W GTEx Tissue Sample Gene Expression Profiles 1.0 1.06631 PU.1-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE205913_1_v_0_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7058-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55C-0326-SM-3GAF1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11456 Ventromedial hypothalamic nucleus, dorsomedial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02805 ubiquitin protein ligase activity GO Molecular Function Annotations 2023 1.0 null Medication use (adrenergics, inhalants) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.752288 A549_PD173074_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.015441 NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.746685 GSE88819_0_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SUDHL8 CCLE Cell Line Gene Expression Profiles 1.0 2.13612 GTEX-QDT8-1326-SM-48TYY GTEx Tissue Sample Gene Expression Profiles 1.0 0.901448 OLIG3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.162 PLB985 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.56235 TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22621 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F4-06A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ppard_23093780_pancreatic_beta_cells_lof_mouse_gpl1261_gds4320 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.161323 6276_PHB_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.522551 inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.846847 7525_RPS3_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.697261 EHF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.3309 GTEX-XPVG-0826-SM-4B654 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.832338 STAT1::STAT2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.2871 Perturb_1318_KO_BATF_SRP201368 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.60337 859_BMS1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.758516 GSE237984_1_v_0_magi1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null intermediate part of the arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78953 HUVEC Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.896634 RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_15008_KD_Klf5_SRP341620 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.64599 mediodorsal nucleus of thalamus_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.69963 germ layer TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EPAS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1953 TMBIM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10692 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE246053_1_v_3_hnf4a_mouse RummaGEO Gene Perturbation Signatures 1.0 null LMO2-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null ACER3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07409 GTEX-PVOW-0011-R3A-SM-32PKX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844929 PMC7244323-elife-55325-supp3.xlsx-Haapaniemi_TP53-KO-Gene_TP53 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44161 H3K79me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NSMCE2 Pathway Commons Protein-Protein Interactions 1.0 null suprachiasmatic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00995 STAT3 ChEA Transcription Factor Targets 1.0 null Ciliated cell_Lung_Human CellMarker Gene-Cell Type Associations 1.0 null TLX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.548 HOP-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.872344 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CJ-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles -1.0 -2.05684 GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -2.17306 2129_DDX54_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.57102 MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER ChEA Transcription Factor Targets 2022 1.0 null GSE144796_1_v_0_linagliptin_mouse RummaGEO Drug Perturbation Signatures 1.0 null lateral subhabenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08901 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HPBALL CCLE Cell Line Gene Expression Profiles 1.0 1.35687 HINFP JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.1332 GTEX-XPT6-0001-SM-4B64G GTEx Tissue Sample Gene Expression Profiles 1.0 0.860188 DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.11372 cellular metabolic process GO Biological Process Annotations 2015 1.0 null BF-97-LS55_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.495248 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7527_RPS5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.79417 TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_3_v_9_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-S3XE-0426-SM-3K2AC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36326 mania GWASdb SNP-Phenotype Associations 1.0 0.664442 SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922271 H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RUNX1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE163240_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null TTF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28551 smc5-smc6 complex GO Cellular Component Annotations 2015 1.0 null ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09885 cuneus, left, peristriate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20966 GSE211177,GSE211178_4_v_10_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null globus pallidus, external segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.980332 intermediate white layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81326 EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZG-0001-SM-47JYF GTEx Tissue Sample Gene Expression Profiles 1.0 0.948645 A-Vietnam-1203-2004(H5N1)_24Hour_None_GSE43204 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.59277 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.97844 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25905 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null polymorphic layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3405 Smc5-Smc6 complex GO Cellular Component Annotations 2025 1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GATA4 ChEA Transcription Factor Targets 1.0 null TEAD4 ENCODE Transcription Factor Targets 1.0 null Basolateral amygdalar nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39242 Gin4 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.638 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XAJ8-1026-SM-47JY9 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.61192 GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles 1.0 2.67016 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25775 GSE168918_1_v_0_tmprss4_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-64-5778-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE239844_7_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null TTC9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10828 H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 15q11q13 copy number variation WikiPathways Pathways 2024 1.0 null Peripheral arterial disease (traffic-related air pollution interaction) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.739794 CEBPB_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17519 GATA3-27048872-CHIP-SEQ-THYMUS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AQ-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148262,GSE150691_1_v_0_hdlbp_human RummaGEO Gene Perturbation Signatures -1.0 null HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12865_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of CoPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29073 VZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00919 5501_NCKIPSD_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.568473 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE89154_1_v_3_proscillaridin_human RummaGEO Drug Perturbation Signatures -1.0 null CEBPD_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAX5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GF-57-LR72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208782 H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.65334 GTEX-QDVJ-1926-SM-2S1PJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01633 GSE93124_0_v_1_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49146 CE-15-YU05_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.307394 FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.470809 GTEX-O5YT-0926-SM-48TDG GTEx Tissue Sample Gene Expression Profiles 1.0 0.999563 mantle zone of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.7287 H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null UACC812 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.600302 TBX5-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null lingual gyrus, right, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00863 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AE-13-CX28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.271688 inner SZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10703 intermediate stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09448 GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80533 BE-36-XE09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.334017 u TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.177 CB-44-FA25_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.205559 GSE199255,GSE199356_4_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZSCAN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59476 GTEX-Q734-0126-SM-48U1E GTEx Tissue Sample Gene Expression Profiles 1.0 1.05664 reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.853814 nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OZ-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02784 KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.921172 Lung adenocarcinoma_LUAD_TCGA-50-8460-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE216043_7_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.88547 JVM-2 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.53808 GSE104022_1_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null GB-46-CK08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.800084 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-HAND1_pos_targets-ID_HAND1 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GATA1_G1E-ER4_mm9_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Colon cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.036 PMC3930188-813067.f1.pdf-97-NR0B1_NR0B1 Rummagene Transcription Factor Associations 2026 1.0 null GTF2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UNCX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.6262 inner CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.851552 JD-44-KF86_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.18762 central layers of TG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41031 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRRX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6053 GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.45044 GTEX-POMQ-0326-SM-2I5FO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17537 CTCF_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KAT2B ENCODE Transcription Factor Targets 1.0 null KYSE-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21648 BC-43-JW95_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.232022 GBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.9557 FHC cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.253 GSE158834_1_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_8528_OE_Nsmce1_SRP141395 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 RS411 CCLE Cell Line Gene Expression Profiles 1.0 1.61749 ventral part of JcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16032 GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.85542 GSE149359_2_v_1_asap2_human RummaGEO Gene Perturbation Signatures 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.926322 FOXA1-21572438-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE147366_1_v_0_med13_human RummaGEO Gene Perturbation Signatures -1.0 null ELK1 ChEA Transcription Factor Targets 1.0 null GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37464 H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null capan2 HPA Cell Line Gene Expression Profiles 1.0 1.2775 FEZF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.9321 H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.864977 GATA4-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GABP-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE82032_3_v_2_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC11185654-media-2.xlsx-WT_DMR_to_WT-LF_DEGS-Unnamed_14_LTF Rummagene Transcription Factor Associations 2026 1.0 null GSE206270_1_v_0_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUPHD1 CCLE Cell Line Gene Expression Profiles 1.0 1.78014 GSE118794_5_v_4_zmynd8_mouse RummaGEO Gene Perturbation Signatures 1.0 null CEBPB ENCODE Transcription Factor Targets 1.0 null NFYA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein ubiquitination GO Biological Process Annotations 2015 1.0 null Nr5a1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.0896 Night sleep phenotypes GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.539794 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA1 ChEA Transcription Factor Targets 1.0 null GSE123943_4_v_3_sox1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7444_RPL19_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.643901 Prostate adenocarcinoma_PRAD_TCGA-G9-6343-01A-21R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Ellagic acid_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0219909 A549_AZD1480_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0118275 metal ion binding GO Molecular Function Annotations 2015 1.0 null GTEX-UJMC-1026-SM-4IHKN GTEx Tissue Sample Gene Expression Profiles 1.0 0.990495 STAT1-20625510-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CA-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WB-48-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.37922 intracellular non-membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null GTEX-N7MS-1626-SM-3LK5F GTEx Tissue Sample Gene Expression Profiles 1.0 1.05156 GSE77108_0_v_7_saha_human RummaGEO Drug Perturbation Signatures 1.0 null GSE178714_6_v_2_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null macromolecular complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27342 embryonic growth retardation MGI Mouse Phenotype Associations 2023 1.0 null GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.914849 r9 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01142 H3K4ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PPARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.3929 GTEX-XQ3S-0001-SM-4B64K GTEx Tissue Sample Gene Expression Profiles 1.0 0.911096 GSE178714_1_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null Cervical carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NFIC ENCODE Transcription Factor Targets 1.0 null Bladder GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.14436 skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles -1.0 -1.98321 Kidney Chromophobe_KICH_TCGA-KL-8327-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Zinc finger, RING-type InterPro Predicted Protein Domain Annotations 1.0 null BV-173 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.06573 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null NCIH1395 CCLE Cell Line Gene CNV Profiles 1.0 1.63268 2731_ESF1_P1 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.568242 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5L5-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lingual gyrus, left, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.7249 cerebellar cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.17244 CEBPB_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GP2D Achilles Cell Line Gene Essentiality Profiles -1.0 -1.48107 POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFYB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RTN4R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09634 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FM-8000-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XQ8I-1826-SM-4BOOJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.18309 GTEX-R55D-0126-SM-48FEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.83302 GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 1.578 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.66356 K562_BRD4770_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0152368 TCFAP2C-20176728-TROPHOBLAST-STEM-CELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null FARAGE COSMIC Cell Line Gene Mutation Profiles 1.0 null FOXA2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null GSE186005_1_v_2_klf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null Rhinitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.052 eGFP-GATA2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VPS28 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10702 GATA4-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GI-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular aromatic compound metabolic process GO Biological Process Annotations 2015 1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3B-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE171175,GSE171181_1_v_2_e7107_human RummaGEO Drug Perturbation Signatures -1.0 null SNU324 CCLE Cell Line Gene CNV Profiles -1.0 -2.69427 inferior occipital gyrus, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.887863 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GABP-19822575-HEPG2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null STAT6-20620947-CD4-POS-T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null A549_WHI-P154_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0181508 A101D CCLE Cell Line Gene Expression Profiles -1.0 -1.61978 NCI-H2126 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.997238 GSE238005_5_v_3_c9orf72_human RummaGEO Gene Perturbation Signatures -1.0 null 7509_RPS19_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.50277 SPI1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE235066_4_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35869 HOXA5 JASPAR Predicted Transcription Factor Targets 1.0 null posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.890842 HCC202 CCLE Cell Line Gene CNV Profiles 1.0 1.72811 G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16438 Hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 primary motor cortex (area M1, area 4)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.974831 GTEX-U8T8-0126-SM-3DB94 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.933764 H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE222574_0_v_2_lmna_mouse RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE133683_1_v_5_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null DE-98-FC24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.318105 Erectile dysfunction_Penis Erectile Tissue_GSE2457 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.25024 MBD4 ENCODE Transcription Factor Targets 1.0 null GSE224556,GSE224557_6_v_1_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WH7G-1526-SM-4LVMX GTEx Tissue Sample Gene Expression Profiles 1.0 0.834025 NCIH1299 Achilles Cell Line Gene Essentiality Profiles 1.0 1.19617 USF1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H6PD_KO_GDS3195_603_mouse_Skeletal muscle - Tibialis anterior GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AD-41-WB70_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.253241 GSE146982_3_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null AE-85-KE62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.271081 transverse gyri, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10644 GTEX-PLZ6-0826-SM-3P61K GTEx Tissue Sample Gene Expression Profiles 1.0 0.972167 NR1I2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1134 PRRX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.369 GTEX-XMD1-2826-SM-4AT5F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.90585 CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null Micronuclei, Chromosome-Defective CTD Gene-Disease Associations 1.0 1.01663 GSE87862_0_v_1_mov10_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49385 GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18101 POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180800,GSE180801_0_v_5_tex10_mouse RummaGEO Gene Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AB-30-CR11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.546944 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null regulation of cellular response to stress GO Biological Process Annotations 2015 1.0 null GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.340522 superior occipital gyrus, left, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04678 GTEX-NFK9-1726-SM-3TW8P GTEx Tissue Sample Gene Expression Profiles 1.0 0.996582 A-CA-04-2009(H1N1)_48Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.58152 GTEX-XYKS-2426-SM-4AT43 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13214 POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TB-06-VB30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.356467 H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.19502 GTEX-X62O-0008-SM-46MU5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22682 PAX5_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE152441,GSE152442_7_v_3_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 17660535-TableS4a GeneSigDB Published Gene Signatures 1.0 null K562_S3I-201_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0163497 intermediate gray layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75876 UMUC1 CCLE Cell Line Gene CNV Profiles 1.0 2.43228 H3K4me3_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SRF-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.1481 PAX5 ENCODE Transcription Factor Targets 1.0 null H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RV-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null all GWASdb SNP-Phenotype Associations 1.0 0.030532 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.44795 GSE203308_6_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null UF-06-JB00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.437841 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null E2F1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.908855 H3K4ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE201042_6_v_1_ptpmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.982944 7442_RPL18A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.540413 inferior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.853624 GSE85880,GSE85881_0_v_1_tretinoin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HNF4A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2BC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06163 YAPC CCLE Cell Line Gene CNV Profiles -1.0 -1.75293 Liver hepatocellular carcinoma_LIHC_TCGA-MI-A75C-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U8T8-1126-SM-4DXUE GTEx Tissue Sample Gene Expression Profiles 1.0 2.09546 POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Obatoclax Mesylate_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0161978 GTEX-Q734-2026-SM-3GADA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.94268 GSE203308_4_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QV44-2026-SM-2S1RD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07578 H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KRAP_Deficiency_GDS3527_566_mouse_Brown adipose tissues GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54688 GSE239844_4_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.2358 primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03611 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me1_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A_CA_04_2009_4dayMOI-10^4_None_GSE37569 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.56109 Nuclear MIS12/MIND complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.525 HOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.7619 SW-48 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.884 inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.877053 RZZ complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.526 GTEX-XMD1-0008-SM-4AT41 GTEx Tissue Sample Gene Expression Profiles 1.0 1.08253 POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Thymic Carcinoma_Thymus_GSE2501 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.46626 DLX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2107 HS-SULTAN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.32212 PMC4944136-srep28995-s2.xls-DUXA-gene_DUXA Rummagene Transcription Factor Associations 2026 1.0 null GSE216043_7_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Colon adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.077 GTEX-P78B-1626-SM-2S1O1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827618 abnormal emotion/affect behavior GWASdb SNP-Phenotype Associations 1.0 0.303363 CF-65-GU65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.462031 Eiii TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.552 GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null blood vessel TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.880304 GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.905671 r9 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62143 abnormal embryo size MGI Mouse Phenotype Associations 2023 1.0 null 496100596_FWM_dementia_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.08686 H3K4me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17406 TEAD4 ChEA Transcription Factor Targets 1.0 null Inflammation CTD Gene-Disease Associations 1.0 1.15089 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33793 H3K9ac_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RELA_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CNTNAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.24681 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E3-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Tfcp2l1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 36.6524 TAL1-20566737-PRIMARY-FETAL-LIVER-ERYTHROID-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU475 CCLE Cell Line Gene Expression Profiles -1.0 -1.5425 FOXA2 ChEA Transcription Factor Targets 1.0 null regulation of response to stimulus GO Biological Process Annotations 2015 1.0 null GTEX-XV7Q-1026-SM-4BRVR GTEx Tissue Sample Gene Expression Profiles 1.0 1.29065 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2896-03B-01T-0751-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null embryonic lethality prior to tooth bud stage MGI Mouse Phenotype Associations 2023 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.940639 GSE224311_3_v_4_chaetocin_human RummaGEO Drug Perturbation Signatures 1.0 null 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.984844 H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null SBDS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13298 MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239844_7_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOS ENCODE Transcription Factor Targets 1.0 null Central lateral nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30254 GATA1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CEBPB_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.977819 Anteroventral periventricular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17309 GTEX-NPJ8-0126-SM-2YUNR GTEx Tissue Sample Gene Expression Profiles 1.0 1.26335 Perturb_5964_KD_SFPQ_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral hypothalamic area, mammillary region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.43714 PDK1_knockout_265_GSE42187 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.7526 posterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.895398 GSE133683_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-0426-SM-2S1PU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10983 Lung squamous cell carcinoma_LUSC_TCGA-77-7465-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39X-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE182680,GSE182683_5_v_4_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 2.48733 7431_RPL10A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.586963 H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Inferior olivary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.18347 Lateral element COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.139 CB-49-OG36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.87918 LNZ308 CCLE Cell Line Gene Expression Profiles -1.0 -1.75261 MCF7_Rucaparib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0173883 COV318 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.52516 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211286_1_v_3_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QV31-0008-SM-447AT GTEx Tissue Sample Gene Expression Profiles 1.0 0.902336 H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WFG7-0826-SM-3GIKU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.96377 TAL1 ChEA Transcription Factor Targets 1.0 null intracellular COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H4K8ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922271 JE-04-LS32_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.242729 Acute Myeloid Leukemia_LAML_TCGA-AB-2856-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158834_7_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCFL_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MFM-223 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.07531 Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC ENCODE Transcription Factor Targets 1.0 null H2BK12ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KMRC-20 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.74852 H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mantle zone of TSPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29484 brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 A549_Nintedanib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0143721 intermediate stratum of isBL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03346 CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Meprednisone_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0185814 POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1234 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13745 CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BTK_knockout_2_GDS1346 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -0.163979 reticular formation of CoPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04885 KLHL25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0456 ANKIB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02115 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.862779 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AD-30-OK99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.326182 Fetal Brain Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -2.07818 anteroventral periventricular preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16809 RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0026 GSE210101,GSE210114_7_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null karpas707 HPA Cell Line Gene Expression Profiles -1.0 -1.30401 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.91056 496100608_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.32584 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Periventricular zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31964 PTEN_01_301 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.58742 GTEX-QLQ7-1726-SM-2S1QQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3488 GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.878266 Perturb_5942_KD_PIAS2_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.58578 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEC-1326-SM-4AT69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53979 primary motor cortex (area M1, area 4)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11064 H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null testis_7e HPA Tissue Sample Gene Expression Profiles 1.0 1.33391 KAT2A ENCODE Transcription Factor Targets 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A3-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null GTEX-XV7Q-1226-SM-4BRVT GTEx Tissue Sample Gene Expression Profiles 1.0 1.14806 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -3.28438 GTEX-Q2AG-1126-SM-48U1P GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844805 TEAD4-22529382-TROPHECTODERM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10465 GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 1.65486 ATF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.9825 RUNX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33847 H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MF-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2977-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PZ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA1_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cardiovascular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POU2F2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE153867_6_v_3_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2969-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.960537 MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Protein kinase C-like, phorbol ester/diacylglycerol-binding domain InterPro Predicted Protein Domain Annotations 1.0 null H3K4me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07238 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null KA-75-LP02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.69468 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null mantle zone of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16315 ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.988233 GSE89154_1_v_0_proscillaridin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Azacitidine_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0118609 endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE65617_2_v_3_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null GTEX-WFG8-1126-SM-4LVN1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.920562 CREB1-26743006-CHIP-SEQ-LNCAP-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE226439,GSE226441_6_v_2_hnf4g_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -2.24656 CEBPB_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4490-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsomedial preoptic area, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03642 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HNF4A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYOD1_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NKM-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.21917 HE-16-PO98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.346392 A549_Motesanib Diphosphate_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0157669 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null PMC6345883-41598_2018_37397_MOESM10_ESM.xlsx-AR_D0_VS_D7_W_B29__TRANS-Gene_Name_AR Rummagene Transcription Factor Associations 2026 1.0 null HMGN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27428 Alzheimer's Disease_Entorhinal cortex_GSE5281 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.70487 SP2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.59646 PMC7880998-41467_2021_21255_MOESM8_ESM.xlsx-Sup_Data_5_TWIST_Panel-Gene_Name_TWIST1 Rummagene Transcription Factor Associations 2026 1.0 null wm115 HPA Cell Line Gene Expression Profiles -1.0 -2.09044 ZR75B Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.748755 FA-80-DR66_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220245 PMC12903452-mmc5.xlsx-ST2-2_OCT4_Off_Targets-Target_Gene_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null primary auditory cortex (core)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.43308 G124 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.40482 H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 1.5897 H3K9ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AC-84-QG99_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.683878 RUNX2 JASPAR Predicted Transcription Factor Targets 1.0 null Perturb_8945_Mut_RB1_SRP220467 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.89503 POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TEAD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ventral posterior complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3745 E2F7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.1777 MCF7_SB431542_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.018536 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25S-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KYM1 CCLE Cell Line Gene Expression Profiles -1.0 -1.69051 ESR1-22446102-UTERI-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_EED226_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176444 RUNX1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SAP30 ENCODE Transcription Factor Targets 1.0 null FA-63-WI26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.242254 GSE186810,GSE186813_3_v_1_furin_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null terete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1345 18451145-TableS1 GeneSigDB Published Gene Signatures 1.0 null ventral part of CoP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24918 Perturb_14494_KO_Igsf11_SRP320670 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.92506 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43822 7480_RPL8_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.504123 BHLHE23 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4563 SIRT1_KO_GDS3666_295_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7SF-0001-SM-3K2BE GTEx Tissue Sample Gene Expression Profiles 1.0 0.894743 FE-29-XM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.296027 primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.36295 Breast_Myoepithelial_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.10992 Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CAR-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922271 GSE203308_7_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null WSUDLCL2 CCLE Cell Line Gene Expression Profiles 1.0 1.57238 GTEX-OIZH-2126-SM-3NB1P GTEx Tissue Sample Gene Expression Profiles 1.0 1.563 E2F1-26619117-HEPATOCYTES-MOUSE-LIVER ChEA Transcription Factor Targets 2022 1.0 null A549_Navitoclax_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0140535 GTEX-WFG7-2226-SM-3GIKP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41641 GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.966877 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28347 ELK1-22589737-MCF10A-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SIN3A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.3971 JD-44-KF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.90247 GSE235066_4_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04377 GTEX-W5WG-2726-SM-4LMIC GTEx Tissue Sample Gene Expression Profiles 1.0 1.4817 core of T-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42551 GINS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31882 9443_TWISTNB_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.566137 POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE178714_1_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OIZH-1326-SM-3NB1H GTEx Tissue Sample Gene Expression Profiles 1.0 1.11087 H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE135350_3_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-TKQ2-0226-SM-4DM6V GTEx Tissue Sample Gene Expression Profiles 1.0 1.21587 BL1118 (SMC5) NURSA Protein Complexes 1.0 null PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.46807 FOXA2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNF4G_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0326-SM-3DB82 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.966891 Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F7-01A-11R-A084-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null outer SZ in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.834747 A-CA-04-2009(H1N1)_36Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.24715 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nose disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.052 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.37609 GTEX-QDVN-0426-SM-48TZ6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26418 cellular response to dna damage stimulus GO Biological Process Annotations 2015 1.0 null H3K4me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FF-86-NH56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.59782 striatum_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.868628 SIGMAR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04511 SETDB1-19884257-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null SRF ChEA Transcription Factor Targets 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.099 MCEE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.31634 GTEX-RUSQ-0226-SM-47JWT GTEx Tissue Sample Gene Expression Profiles 1.0 0.886104 NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION ChEA Transcription Factor Targets 2022 1.0 null GTEX-U4B1-1626-SM-3DB8N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.63143 A549_Droxinostat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0145733 GSE127790_10_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EF-85-DA07_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.315524 CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE227592_6_v_1_adar_human RummaGEO Gene Perturbation Signatures 1.0 null AD-54-FG24_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.231721 6581_POT1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.542444 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128076_2_v_0_doxycycline_human RummaGEO Drug Perturbation Signatures -1.0 null cingulum bundle, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41739 CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17676974-TableS2 GeneSigDB Published Gene Signatures 1.0 null GSE120370_0_v_6_thrombin_mouse RummaGEO Drug Perturbation Signatures 1.0 null zonal layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33161 MCF7_Maraviroc_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0141274 H3K4me1_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SCC9 CCLE Cell Line Gene Expression Profiles -1.0 -1.65966 GSE114013,GSE114014_0_v_3_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null ELF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.2216 CC-55-CD84_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.229381 regulation of telomere maintenance GO Biological Process Annotations 2023 1.0 null cytosol COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 embryonic growth retardation IMPC Knockout Mouse Phenotypes 1.0 null 17495134-TableS1 GeneSigDB Published Gene Signatures 1.0 null GTEX-PSDG-1426-SM-48TD1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.933214 UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.853077 ventral tegmental area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.98813 GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -2.02243 TAL1-26923725-CHIP-SEQ-HEMANGIOBLAST-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE120612_7_v_2_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.533704 GTEX-SJXC-2026-SM-4DM6N GTEx Tissue Sample Gene Expression Profiles 1.0 1.51871 ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.96595 GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10133 GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.89966 LD-69-ZV56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.289828 BEN CCLE Cell Line Gene CNV Profiles 1.0 2.12151 FOXA1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 184A1N4 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.681114 MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7451_RPL24_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.509412 E2F6 ENCODE Transcription Factor Targets 1.0 null GSE77108_4_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POYW-1126-SM-48TCI GTEx Tissue Sample Gene Expression Profiles 1.0 0.881442 superior colliculus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.942842 GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0942 REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-BatSRBD_48Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.43708 K562_PCI-34051_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0199506 superficial stratum of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03642 GSE147876,GSE147877_4_v_6_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null PMC12077394-giaf035_giga-d-24-00380_original_submission.pdf-13-HMG20B_HMG20B Rummagene Transcription Factor Associations 2026 1.0 null GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08892 STAT3-19079543-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K9ac_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null amygdaloid complex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.936323 GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13865 GTEX-R55E-0008-SM-48FCG GTEx Tissue Sample Gene Expression Profiles 1.0 0.952058 Prostate adenocarcinoma_PRAD_TCGA-EJ-A65B-01A-12R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NB-12-ZK38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.381974 FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE228106_3_v_4_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null SIRT6 ENCODE Transcription Factor Targets 1.0 null GSE171572_0_v_2_tp53_human RummaGEO Gene Perturbation Signatures 1.0 null chromosomal part GO Cellular Component Annotations 2015 1.0 null GSE228106_3_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ubiquitin-like protein transferase activity GO Molecular Function Annotations 2023 1.0 null superficial stratum of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24403 UF-85-NE30_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.295018 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.889154 POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1-22589737-MCF10A-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Periventricular hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70697 MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TMMY-0226-SM-33HBA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.8972 AB-18-YN11_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.256739 MCF7_Tofacitinib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0162379 GSE240896,GSE240899_2_v_4_ccnt1_human RummaGEO Gene Perturbation Signatures 1.0 null SNU13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00859 cellular protein metabolic process GO Biological Process Annotations 2015 1.0 null Brain_Germinal_Matrix Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.26651 hsa-miR-1972 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE124410_6_v_0_stk40_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.910871 HT1376 CCLE Cell Line Gene CNV Profiles 1.0 2.24218 FOXA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RELA JASPAR Predicted Transcription Factor Targets 1.0 null ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.16423 reticular nucleus of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.909944 superior occipital gyrus, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.900383 TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SPI1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_WP1066_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167097 GTEX-RWSA-0008-SM-47JYX GTEx Tissue Sample Gene Expression Profiles 1.0 0.840666 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32622 mood disorder GWASdb SNP-Disease Associations 1.0 0.333623 GSE163282_12_v_8_aspirin_human RummaGEO Drug Perturbation Signatures 1.0 null DMS454 CCLE Cell Line Gene CNV Profiles 1.0 1.34273 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBJ-3026-SM-3NB1D GTEx Tissue Sample Gene Expression Profiles 1.0 0.849867 Runx1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.3505 SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0616 GSE169205_3_v_6_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.08086 A172 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.30367 CHD2 ENCODE Transcription Factor Targets 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA3-21867929-CD8-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SEMA6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33434 NUP58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.85034 intermediate stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.30488 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null DA-85-SU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.267033 Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GA-61-GX82_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.598448 BACH1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null SIHA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09846 YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-QQ-A5V2-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ESO26 COSMIC Cell Line Gene CNV Profiles 1.0 4.51153 interleukin-4 receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.551 GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.920904 H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_Activation - 4 hours_GDS2025_724_mouse_Pancreatic islet beta cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 Perturb_12918_KD_C1orf186_SRP411666 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.42112 PAX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4018 CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ7-0006-SM-3GACR GTEx Tissue Sample Gene Expression Profiles 1.0 1.06775 EFM19 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.24189 NCI-H1623 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.08029 F36P CCLE Cell Line Gene CNV Profiles -1.0 -1.36977 GI-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.08249 Upper respiratory tract disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.052 3557_GSTCD_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.587826 GSE74251_2_v_3_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null NOP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.40723 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AI-0226-SM-48U1D GTEx Tissue Sample Gene Expression Profiles 1.0 1.06977 Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.58056 dorsomedial part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47616 POLR2A_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-1326-SM-2TF6T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37656 GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles 1.0 1.27222 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43U-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NA-30-HS87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.238634 posteroventral (inferior) parietal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.50292 H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null caudal (posterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.84302 POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Alvespimycin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0140423 RHBDF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29853 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DL-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DNA damage response GO Biological Process Annotations 2023 1.0 null POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.896421 HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.921172 GTEX-SUCS-1626-SM-32PLS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7434 PB-40-YB26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.34486 GSE175787_4_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6493_PNO1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.530036 Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPZ ENCODE Transcription Factor Targets 1.0 null GTEX-V955-0726-SM-3GAFG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.877369 anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.85143 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XLM4-0004-SM-4AT5I GTEx Tissue Sample Gene Expression Profiles 1.0 0.876082 MAGEF1 Pathway Commons Protein-Protein Interactions 1.0 null H3K23me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HC-92-HE59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.217605 GSE230263,GSE230265_5_v_1_runx1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80393 midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.921132 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5400-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 single-organism process GO Biological Process Annotations 2015 1.0 null cerebellar cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.52849 184B5 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.13953 GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.8464 EGFR_drugactivation_30_GDS4361 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.27708 BC-00-YH62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.340398 MCF7_Obatoclax Mesylate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0163727 POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-REY6-2126-SM-48FD9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.68047 duodenum HPA Tissue Gene Expression Profiles -1.0 -0.900249 Vagina GTEx Tissue Gene Expression Profiles 2023 1.0 1.19774 6219_PES1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.602117 SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.33595 mammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40274 Bed nuclei of the stria terminalis, anterior division, oval nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36618 condensed chromosome GO Cellular Component Annotations 2025 1.0 null hippocampus (hippocampal formation)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26213 5232_MRPL49_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.575621 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01081 GSE100863,GSE100864_3_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null A549_UNC1999_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0154329 Adrenocortical cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.777 Aortic adventitial fibroblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.693 inferior olive, principal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06462 CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA ChEA Transcription Factor Targets 2022 1.0 null 7463_RPL35_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.657634 membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null smc5-smc6 complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.18 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X4XY-0006-SM-46MV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04391 MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.706376 Lung squamous cell carcinoma_LUSC_TCGA-18-3421-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWOO-0326-SM-48TDB GTEx Tissue Sample Gene Expression Profiles 1.0 1.3415 Lung adenocarcinoma_LUAD_TCGA-50-6597-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_PFI-1_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0181866 CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.74152 CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE160817_2_v_8_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null E2F4 ENCODE Transcription Factor Targets 1.0 null GSE172295_4_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null r9 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.82519 Prostate adenocarcinoma_PRAD_TCGA-J4-A67Q-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 6152_PDCD11_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.63423 GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCoV-EMC2012_3Hour_23631916_GSE45042 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.97531 GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.51179 CE-04-HT15_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.22566 GTEX-OHPM-1626-SM-2HMK4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34497 primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.53023 HB-06-WU12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.292205 H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.372 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PSDG-0426-SM-2S1OF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92759 JUN-26020271-SMOOTH-MUSCLE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ubiquitin protein ligase activity GO Molecular Function Annotations 2025 1.0 null GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.85514 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JK-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DA-35-DU85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248732 lateral SC part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91862 intracellular part GO Cellular Component Annotations 2015 1.0 null GSE227891_5_v_0_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null Micronucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.539 Cardiovascular system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.742 ME-49-AE45_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.26122 GSE210101,GSE210114_0_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUM185PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.95601 ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null core part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22495 Brain Lower Grade Glioma_LGG_TCGA-DB-5274-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYC_Activation - 2 hours_GDS2025_723_mouse_Pancreatic islet beta cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Prostate BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.1254 Superior colliculus, motor related, deep gray layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1109 posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.17518 H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null K562_Triamcinolone Acetonide_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.013052 GSE224556,GSE224557_8_v_1_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LA-66-RT74_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.275076 H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE147876,GSE147877_4_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null terminal hypothalamus (rostral hypothalamus) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20568 AC-35-CK01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.448019 occipito-temporal gyrus, left, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.991636 POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MBD4_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.12864 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.65231 PMC12077394-giaf035_giga-d-24-00380_revision_1.pdf-15-HMG20B_HMG20B Rummagene Transcription Factor Associations 2026 1.0 null PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE65617_0_v_4_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null corpus callosum Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.54872 A549_Alisertib_10然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0118656 rt4 HPA Cell Line Gene Expression Profiles -1.0 -1.2771 GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.20378 catalytic activity GO Molecular Function Annotations 2015 1.0 null PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null occipital pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.92267 PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null hippocampus (hippocampal formation)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.45174 TAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Q7-1526-SM-3K2AG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22188 thymus BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.12701 PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR Rummagene Transcription Factor Associations 2026 1.0 null mantle zone of JcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16032 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VJWN-0426-SM-3GIJI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.885032 CEBPB-22108803-LS180-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K79me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WL46-0126-SM-3TW8I GTEx Tissue Sample Gene Expression Profiles 1.0 0.93852 periventricular stratum of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.23603 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100620_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.53851 Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of DNA metabolic process GO Biological Process Annotations 2023 1.0 null SPI1-20517297-HL60-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null PML_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC loading complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.071 occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.17769 MCF7_Lapatinib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0176428 TCF12 ENCODE Transcription Factor Targets 1.0 null CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V1D1-0226-SM-4JBHG GTEx Tissue Sample Gene Expression Profiles 1.0 1.00974 Kidney Chromophobe_KICH_TCGA-KN-8423-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null outer SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00516 CAL120 CCLE Cell Line Gene CNV Profiles -1.0 -1.94474 intracellular membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 BT20_BREAST CCLE Cell Line Proteomics 1.0 2.23966 posterior (ventral) nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.08637 GTEX-T5JW-1826-SM-3GAE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28822 Retinitis pigmentosa 11 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.033 NCI-H660 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.26879 HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.964983 C-33 A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE226983_2_v_0_ddx5_mouse RummaGEO Gene Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JE-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27378 WiDr cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.975 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.25607 PFEIFFER CCLE Cell Line Gene CNV Profiles 1.0 1.52795 1040_C1ORF131_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.08221 GLUD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77879 paracentral lobule, posterior part, left, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.973566 lateral (parvicellular) part of MD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51046 GSE201668_0_v_1_ncor2_human RummaGEO Gene Perturbation Signatures 1.0 null ubiquitin-like protein ligase activity GO Molecular Function Annotations 2025 1.0 null enlarged spleen IMPC Knockout Mouse Phenotypes 1.0 null NR3C2-34362910-WISTARRAT-HIPPOCAMPUS ChEA Transcription Factor Targets 2022 1.0 null CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE163240_3_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.933087 Endodeoxyribonuclease complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.922 intermediate stratum of p2ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5909 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.313 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A1-11A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular organelle GO Cellular Component Annotations 2015 1.0 null GSE169590_6_v_1_rptor_human RummaGEO Gene Perturbation Signatures -1.0 null GATA1_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE160817_3_v_9_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null RUNDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3402 GSE184902_4_v_1_adipor1_mouse RummaGEO Gene Perturbation Signatures 1.0 null cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.42822 GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.924189 Postpiriform transition area, layers 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11476 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.18683 CTCF_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_10_GATA1 Rummagene Transcription Factor Associations 2026 1.0 null GSE223287,GSE223290_2_v_4_braf_mouse RummaGEO Gene Perturbation Signatures -1.0 null FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE112860_9_v_8_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null MCF7_Busulfan_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147586 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null 1651_CLEC2L_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.60558 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE139455_7_v_6_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null GTEX-TSE9-2926-SM-3DB77 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.894936 C3A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.890336 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LYL1 ChEA Transcription Factor Targets 1.0 null GSE135352_2_v_4_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE233183,GSE233187_2_v_9_larp1_human RummaGEO Gene Perturbation Signatures -1.0 null PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML2-OVERLAP_GENES_RUNX3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.91141 hippocampus (hippocampal formation)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30275 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null r10 part of spinal vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38684 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AA-56-AB37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.202907 Digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null cognitive disorder GWASdb SNP-Disease Associations 1.0 0.116688 PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR Rummagene Transcription Factor Associations 2026 1.0 null ICAM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11013 K562_SRT3025 HCl_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0163985 496100485_PCx_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.2313 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intercalate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0044 ARID3A ENCODE Transcription Factor Targets 1.0 null GSE216352,GSE216354_1_v_0_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6II-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of Dg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44075 GSE147876,GSE147877_4_v_10_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE178907_0_v_3_fkrp_human RummaGEO Gene Perturbation Signatures -1.0 null JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.72965 GSE206516,GSE206518_2_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null CORL24 CCLE Cell Line Gene CNV Profiles -1.0 -1.42991 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEP G2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11648 BA-77-US35_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.955774 lateral tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03565 CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null placenta TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CTCF_GM12864_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE69869_0_v_1_panobinostat_mouse RummaGEO Drug Perturbation Signatures -1.0 null 496100514_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.01085 Bladder Urothelial Carcinoma_BLCA_TCGA-S5-A6DX-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4981-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.72112 H3K79me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JURKAT, CLONE E6-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null 8656_TAF1A_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.636326 NCIH2172 CCLE Cell Line Gene CNV Profiles 1.0 1.89827 medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.515 PMC6225799-annrheumdis-2018-213524supp003.xlsx-Activated-state-LPS-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null intermediate stratum of m1AD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12853 KC-32-GO33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.274572 red nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33592 GSE238005_4_v_3_c9orf72_human RummaGEO Gene Perturbation Signatures -1.0 null rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19256 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CEBPB JASPAR Predicted Transcription Factor Targets 1.0 null regulation of response to dna damage stimulus GO Biological Process Annotations 2015 1.0 null BA-56-QV45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.97869 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4839-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10863267-12864_2024_10083_MOESM1_ESM.pdf-247-ZNF518A_ZNF518A Rummagene Transcription Factor Associations 2026 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A77O-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE142210_9_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GSE151364,GSE151366_1_v_2_taf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cells - Cultured fibroblasts GTEx Tissue Gene Expression Profiles 2023 1.0 1.05881 7513_RPS24_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.640585 SNU878 CCLE Cell Line Gene Expression Profiles -1.0 -1.97654 7526_RPS4X_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.571816 496100385_TCx_dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.10121 skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.41781 GTL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.977819 ZBTB7A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleic acid metabolic process GO Biological Process Annotations 2015 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.56062 GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830013 umbilical cord TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null TOV21G Achilles Cell Line Gene Essentiality Profiles -1.0 -1.16619 POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77603 GSE131377_1_v_3_spocd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null r7 part of the dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01142 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Cleavage apparatus septin structure COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.638 YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Celecoxib_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144616 NCI-H441 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.904562 GATA1-19941827-MEL-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Bed nucleus of the accessory olfactory tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27967 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.30006 ZNF217-24962896-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null chromatin looping GO Biological Process Annotations 2025 1.0 null H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null DA-27-BW20_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.4078 GSE188870,GSE188871_4_v_2_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAL1-20566737-PRIMARY FETAL LIVER ERYTHROID CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intralaminar nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29587 orbital frontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.899278 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_1_v_5_palm_human RummaGEO Gene Perturbation Signatures -1.0 null NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WRHU-0826-SM-3MJFN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01507 GSE144796_3_v_0_linagliptin_mouse RummaGEO Drug Perturbation Signatures 1.0 null A549_Celecoxib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.014028 GTEX-XBED-0003-SM-47JWP GTEx Tissue Sample Gene Expression Profiles 1.0 0.830464 SOX2-27498859-CHIP-SEQ-STOMACH-MOUSE ChEA Transcription Factor Targets 2022 1.0 null 496100440_FWM_possible Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.64769 embryonic lethality prior to tooth bud stage IMPC Knockout Mouse Phenotypes 1.0 null Epilepsy_lymphoblast_GSE7486 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.34568 Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.960077 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.902208 H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE149264,GSE149267_4_v_5_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.23776 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.17143 CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFON-0326-SM-3GIKX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.850732 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null zinc ion binding GO Molecular Function Annotations 2015 1.0 null GTEX-OHPK-1326-SM-3MJGN GTEx Tissue Sample Gene Expression Profiles 1.0 0.971431 HCC78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.864113 H3K4me1_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 17638893-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null Necrosis CTD Gene-Disease Associations 1.0 1.24275 SU-DHL-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.734 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cuneate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.868886 GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 3.45794 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TE-87-FM14_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.422979 H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Chromosome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OHPN-0011-R11A-SM-2I5FM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19726 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 496100410_TCx_possible Alzheimer's disease_TBI_87_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.085 MXI1 ENCODE Transcription Factor Targets 1.0 null rhombomere 11 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70351 Perturb_7654_OE_CTCF_SRP128556 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -10.1785 TAF1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null chromosomal region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.006776 PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2 Rummagene Transcription Factor Associations 2026 1.0 null Zinc finger, RING-like InterPro Predicted Protein Domain Annotations 1.0 null BD-85-OV63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.243801 GSE236262_0_v_3_trim28_mouse RummaGEO Gene Perturbation Signatures 1.0 null K562_Mocetinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147158 AA-71-XO01_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.234242 4950_MED27_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.505769 GSE139455_2_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.99192 GTEX-XMK1-1026-SM-4B65H GTEx Tissue Sample Gene Expression Profiles 1.0 1.20372 H3K4me2_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null GTEX-S3XE-0126-SM-4AD4R GTEx Tissue Sample Gene Expression Profiles 1.0 0.989733 protein sumoylation GO Biological Process Annotations 2025 1.0 null H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null CADM1_Deficiency_GDS2027_722_mouse_Testis GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22968 NIHOVCAR3 CCLE Cell Line Gene CNV Profiles -1.0 -1.58535 GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40973 Fanconi anaemia nuclear complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.547 Muscular Dystrophy_Muscle - Striated (Skeletal) (MMHCC)_GSE2629 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.94213 GTEX-VUSG-2626-SM-4KKZI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42177 SU-DHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05812 rostral putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.971149 GSE184902_3_v_0_adiponectin_mouse RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02146 medial part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72723 H3K4me3_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 496100296_PCx_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.09915 A-CA-04-2009(H1N1)_48Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.24631 testis_7f HPA Tissue Sample Gene Expression Profiles 1.0 1.14251 internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null STAT5A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE206270_2_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null SKM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.852329 dorsolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.00844 Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE124932_2_v_1_sarm1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-NFK9-1226-SM-3LK79 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05762 BB-62-SZ35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.251776 abnormal uterus morphology IMPC Knockout Mouse Phenotypes 1.0 null Hippocampal cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.915 POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null doxorubicin_homo sapiens_gpl6947_gse25741 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE123022,GSE123030_2_v_6_trem2_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_Alisertib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0167212 T47D Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.22749 GTEX-QDVJ-1126-SM-48U1U GTEx Tissue Sample Gene Expression Profiles 1.0 1.35297 NCOR1 ENCODE Transcription Factor Targets 1.0 null SLR20 CCLE Cell Line Gene Expression Profiles 1.0 2.14812 diethylstilbestrol_mus musculus_gpl6887_gse37969 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.95233 MAX_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54325 GTEX-XUW1-0005-SM-4BOQ7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.944901 HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.30981 MZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.32208 BA-84-TD72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.328294 Brain Lower Grade Glioma_LGG_TCGA-HT-A4DS-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.34897 POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_AG-490_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137894 GSE149264,GSE149267_4_v_3_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE201042_6_v_4_ptpmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZMIZ1 ENCODE Transcription Factor Targets 1.0 null intracellular membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null JM1 CCLE Cell Line Gene Expression Profiles 1.0 1.7775 GSE249098_1_v_2_mthfd1l_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-58-8392-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-X5EB-1826-SM-4E3K8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21479 SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Islands of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0171 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ2-0004-SM-3NMAC GTEx Tissue Sample Gene Expression Profiles 1.0 0.937622 layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.24635 REST ENCODE Transcription Factor Targets 1.0 null Bed nuclei of the stria terminalis, anterior division, anterolateral area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53062 Chromocenter COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.958 H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null EBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2 ChEA Transcription Factor Targets 1.0 null AQR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1028 GTEX-RU1J-1726-SM-2TF5S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32221 HNF4G_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17910759-TableS5 GeneSigDB Published Gene Signatures 1.0 null MCF7_S-Ruxolitinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151556 H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null KARPAS299 CCLE Cell Line Gene Expression Profiles 1.0 1.35404 H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE131887_1_v_4_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-R55E-0826-SM-2TC5M GTEx Tissue Sample Gene Expression Profiles 1.0 1.07276 Peripheral artery disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.742 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAFF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-XG-A823-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2 Rummagene Transcription Factor Associations 2026 1.0 null 7466_RPL36_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.562823 PANC0327 CCLE Cell Line Gene CNV Profiles -1.0 -1.39308 regulation of response to stress GO Biological Process Annotations 2015 1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null 9164_TOMM22_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.537166 single-organism cellular process GO Biological Process Annotations 2015 1.0 null superficial stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1349 skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -1.45412 H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.848745 7527_RPS5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.518401 7512_RPS23_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.540905 SIHA CCLE Cell Line Gene CNV Profiles -1.0 -1.51603 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Condensin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.259 CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-0426-SM-48TZX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31236 GSE125403_7_v_6_venetoclax_human RummaGEO Drug Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adenoma, Liver Cell CTD Gene-Disease Associations 1.0 1.27502 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HCT-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10514 cellular response to stress GO Biological Process Annotations 2015 1.0 null H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.85807 GTEX-OIZI-0626-SM-2XCEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38694 orbital frontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.914691 JD-44-KF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.03365 PMC9669639-mmc3.xlsx-NRLonly-degs-207-Single_cell_RNA-seq_differentially_expressed_genes_between_control_versus_USH1B_NRL_cells_NRL Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1 Rummagene Transcription Factor Associations 2026 1.0 null mammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40274 mammillary part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13161 MIXL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.6323 GSE253056_0_v_1_erythropoietin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Inner kinetochore COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.632 FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.631 CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRR14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36319 H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE57871_1_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null OB-17-DQ74_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.348484 GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE228261_0_v_1_elesclomol_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0616 double-strand break repair via homologous recombination GO Biological Process Annotations 2023 1.0 null 496100278_FWM_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05251 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE178714_1_v_2_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null SIN3A ENCODE Transcription Factor Targets 1.0 null GSE125782_0_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PW2O-1726-SM-2S1OO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851713 GSE218949_0_v_1_cep20_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-R55F-1526-SM-2TF4X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16081 H3K4me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null intermedioposterior nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13435 GTEX-XUJ4-1126-SM-4BOPC GTEx Tissue Sample Gene Expression Profiles 1.0 1.12764 GTEX-V955-0004-SM-3NMDH GTEx Tissue Sample Gene Expression Profiles 1.0 0.826438 CA-42-YI34_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21591 Lateral reticular nucleus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16108 BE-36-XE09_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.248054 DRGX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.8073 GTEX-NFK9-0926-SM-2HMJU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04296 Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.993577 Perturb_6383_KO_Mettl14_SRP344542 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.36157 BD-61-OO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.964701 ventral premammillary nucleus (migrated) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18554 midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09119 GTEX-P4QS-0726-SM-3NMCZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.992093 ABL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18995 umbilical artery TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null fertilizedegg BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.888205 mantle zone of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09253 Prostate adenocarcinoma_PRAD_TCGA-J4-A67N-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PB-09-OE00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.221265 H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.885085 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoplasm COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K4me3_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null TE9 Achilles Cell Line Gene Essentiality Profiles 1.0 1.09935 GSE132408_1_v_3_tet2_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ezh2_deficiency_GDS2717_141_mouse_lymph node T cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null striatum_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.03844 GTEX-XQ8I-1626-SM-4BOOI GTEx Tissue Sample Gene Expression Profiles 1.0 1.14646 RB_P130_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null periventricular stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02737 dorsolateral SC part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.64137 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null SUPT11 CCLE Cell Line Gene Expression Profiles 1.0 3.40796 Adenoma of small intestine_Intestinal Epithelium_GSE422 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.59902 A549_Meprednisone_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156412 BEN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22866 REST_Panc1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null AD-54-FG24_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.20127 VENTX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32188 GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -0.994783 PA-75-VL17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.692497 striatum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.46313 YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCAR-3 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.96747 RELA_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7536_RPS6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.728199 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.912212 K562_Tazemetostat_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157253 mediodorsal nucleus of thalamus_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.62852 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CA SKI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.50522 GSE239844_7_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null periventricular stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43427 EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null interstitial nucleus of the zona limitans Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58977 GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.90892 dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04571 YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAGEA1 Pathway Commons Protein-Protein Interactions 1.0 null Pancreas TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UACC-62 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.906974 A549_PD173074_10然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0177444 Nasal cavity disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.052 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1PU-01A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ventral posterolateral nucleus of the thalamus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03804 STAT6-20620947-CD4_POS_T-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE114013,GSE114014_0_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.247 efo21 HPA Cell Line Gene Expression Profiles 1.0 1.33272 PB-09-OE00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.284136 dorsalstriatum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.29818 GTEX-XBED-1126-SM-48TCF GTEx Tissue Sample Gene Expression Profiles 1.0 0.825772 sp3_17923686_e12dot5_heart_lof_mouse_gpl1261_gds3058 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.496727 GSE185944_0_v_1_pth1r_mouse RummaGEO Gene Perturbation Signatures -1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null optic fiber layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.68077 GTEX-S341-0426-SM-4AD5L GTEx Tissue Sample Gene Expression Profiles 1.0 0.870618 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Alzheimer Disease DisGeNET Gene-Disease Associations 1.0 null Subparaventricular zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38825 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.8603 GSE215086_0_v_1_batf_mouse RummaGEO Gene Perturbation Signatures -1.0 null organic substance metabolic process GO Biological Process Annotations 2015 1.0 null PMC8514013-bloodcandisc-2-450-s007.xlsx-FOXP3_mRNA-Unnamed_2_FOXP3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null REST_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CALD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51855 17210682-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5175-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Foxj3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.594 Amylin receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.924 mantle zone of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.66752 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2A5-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FD-59-TC81_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.322792 RPH3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57491 3871_HNRNPL_P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.686992 GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20098 GSE165579_0_v_1_opa1_mouse RummaGEO Gene Perturbation Signatures -1.0 null E2F4_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FARAGE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.27871 MEC-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.327 MCF7_MLN8054_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147481 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Replication fork protection complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.058 SP1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-A7M4-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50814 H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-V1D1-2126-SM-4JBH4 GTEx Tissue Sample Gene Expression Profiles 1.0 2.18686 GSE235066_4_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null PPARG ChEA Transcription Factor Targets 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 NCI-H460 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.834943 PPARG-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24389 GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3381 GSE213588_8_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -0.908245 TMEM8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26547 CEBPZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6709_PPY_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.86775 Acute Myeloid Leukemia_LAML_TCGA-AB-2966-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60167 TAF1_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A253 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.53086 GTEX-XXEK-0004-SM-4BRWO GTEx Tissue Sample Gene Expression Profiles 1.0 1.03391 PTPN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11358 pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.304539 GSE145445,GSE145454_0_v_1_cop1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE172295_1_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Prostate Carcinoma DisGeNET Gene-Disease Associations 1.0 null 496100409_FWM_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05995 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null JUN JASPAR Predicted Transcription Factor Targets 1.0 null FOXM1 ENCODE Transcription Factor Targets 1.0 null bcl11b_18199763_brain_lof_mouse_gpl1261_gds3178 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.707006 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Stomach Smooth Muscle Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.10549 GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07665 TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AE-56-SL06_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.433161 POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.53198 striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08114 RFX5 ENCODE Transcription Factor Targets 1.0 null TCEAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.71737 MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null adrenal gland GTEx Tissue Gene Expression Profiles 1.0 1.73916 globus pallidus, external segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.042 Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNMC-0126-SM-2XCFO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24214 DA-58-LZ09_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.829385 STAT3 ENCODE Transcription Factor Targets 1.0 null GTEX-PLZ6-1526-SM-2S1OC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.847318 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7U8-06A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null response to stimulus GO Biological Process Annotations 2015 1.0 null Microsporidian TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.576 Umbilical cord blood TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7539_RPS9_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.56126 LA-42-ER00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.61718 GSE169356_0_v_5_ivermectin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.2941 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A519-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE249893_1_v_0_tfam_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.881986 cd4.Tcell BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.06364 JMSU1 CCLE Cell Line Gene CNV Profiles -1.0 -1.41844 H3K23me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-QVJO-0126-SM-3GIK4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.896983 Kidney Chromophobe_KICH_TCGA-KL-8326-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ubiquitin-protein transferase activity GO Molecular Function Annotations 2023 1.0 null ubiquitin-like protein ligase activity GO Molecular Function Annotations 2023 1.0 null H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null HCC364 CCLE Cell Line Gene CNV Profiles -1.0 -1.74781 GSE88819_1_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.08237 NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08198 BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA1_G1E-ER4_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3B-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-QEL4-0626-SM-3GIJM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35046 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null C-4-I Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.85916 MYC_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4P3-1626-SM-3K2AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78657 GSE182680,GSE182683_10_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.84338 IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.65419 Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A763-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LNZTA3WT4 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.72052 PC14 CCLE Cell Line Gene CNV Profiles 1.0 1.52426 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null rostral paraventricular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43644 GTEX-U412-0226-SM-3NMC8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.38954 SUMO ligase complex GO Cellular Component Annotations 2023 1.0 null chromosomal region GO Cellular Component Annotations 2015 1.0 null GSE129244_3_v_5_lmo2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SARS-CoV_84Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.12084 MNX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.5177 MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCT-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null cellular nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null GTEX-WVLH-0626-SM-3MJG7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.893183 Calcitonin family receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.736 H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hydrometra IMPC Knockout Mouse Phenotypes 1.0 null GSE147876,GSE147877_2_v_11_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null ventrolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.930218 Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PLZ6-1126-SM-3P5ZR GTEx Tissue Sample Gene Expression Profiles 1.0 1.00945 GTEX-Q2AH-1026-SM-48TZI GTEx Tissue Sample Gene Expression Profiles 1.0 1.19617 GTEX-TMZS-0326-SM-3DB9P GTEx Tissue Sample Gene Expression Profiles -1.0 -0.82917 OKAJIMA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17396 intermediate stratum of CoPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31392 cerebellar cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.843997 EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-208a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 IRF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.1875 ZFAND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12691 SRF-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RUNX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5452 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AN-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null Colon - Sigmoid GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.47351 USF2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AH-0526-SM-2I3ED GTEx Tissue Sample Gene Expression Profiles -1.0 -0.962427 rhombomere 10 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76244 ZNF184 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.0629 GATA3-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Colonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.024 COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.964983 COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.04012 MYOD1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null tonsil HPA Tissue Gene Expression Profiles 1.0 0.867905 HCFC1 ENCODE Transcription Factor Targets 1.0 null TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-0726-SM-3NB1I GTEx Tissue Sample Gene Expression Profiles 1.0 0.846195 CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70085 PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM5B ENCODE Transcription Factor Targets 1.0 null GSE248045,GSE248046_6_v_1_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary motor cortex (area M1, area 4)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.42463 outer SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23289 MET_knockout_256_GSE25583 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.86981 7536_RPS6_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.670131 Ndc80 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.682 KDM5A ENCODE Transcription Factor Targets 1.0 null A549_AG-14361_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0142394 H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null increased circulating total protein level MGI Mouse Phenotype Associations 2023 1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 TCF12/HEB-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MYC_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mesothelioma_MESO_TCGA-MQ-A6BN-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC1 ENCODE Transcription Factor Targets 1.0 null H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Psoas_Muscle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.954776 regulation of biological process GO Biological Process Annotations 2015 1.0 null GTEX-QESD-0526-SM-2I5G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12421 TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXO3-22982991-MACROPHAGES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null ZNF460 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 121.136 RNF113A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.51351 superficial stratum of CoPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14954 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FE-56-PV35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.90252 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58033 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-HAND1_pos_targets-Gene_HAND1 Rummagene Transcription Factor Associations 2026 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null biological regulation GO Biological Process Annotations 2015 1.0 null SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15783 TFAP2C ChEA Transcription Factor Targets 1.0 null COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.869163 Lung squamous cell carcinoma_LUSC_TCGA-34-5927-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KMS26 CCLE Cell Line Gene CNV Profiles 1.0 1.68358 GLI3T_Lipofectamine transfection_GDS4346_616_human_Panc-1 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25677 EFO27 Achilles Cell Line Gene Essentiality Profiles 1.0 1.12837 DA-35-DU85_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.42458 OE-78-XD40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.698984 SKMM2 CCLE Cell Line Gene CNV Profiles 1.0 1.56244 AC-55-XA97_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.350099 POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null colliculus superior Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.84271 CEBPB-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55D-0626-SM-3GAD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21623 organelle LOCATE Curated Protein Localization Annotations 1.0 null A549_Fluorouracil_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0190334 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG7-0726-SM-3GIKO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0503 dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01951 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5185-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.94905 raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2313 POLR2A_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WM-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.93694 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Tuberomammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12876 dorsolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.930795 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HNF4G ENCODE Transcription Factor Targets 1.0 null intermediate stratum of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29394 MCF7_PF-3845_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0171783 GTEX-XOTO-0526-SM-4B662 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.972861 GTEX-Q2AH-0126-SM-48U2B GTEx Tissue Sample Gene Expression Profiles 1.0 1.52286 TIA1_KO_GSE54418_267_mouse_spinal cord GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TAF1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DKMG CCLE Cell Line Gene CNV Profiles -1.0 -2.37313 abnormal embryo size IMPC Knockout Mouse Phenotypes 1.0 null CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null protein binding GO Molecular Function Annotations 2015 1.0 null GSE128099,GSE128159_3_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null PBX3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleus GO Cellular Component Annotations 2023 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6ES-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null striatum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.22055 GSE199899_1_v_0_diethylnitrosamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null lateral mammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24358 JC-06-ED36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.10786 GSE188570,GSE188571_5_v_2_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null membrane-bounded organelle LOCATE Curated Protein Localization Annotations 1.0 null GSE89018_12_v_2_cry2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05376 10348_ZNF423_ENST00000262383.2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.900055 bed nucleus of the stria terminalis, mediocentral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44256 GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22369 GTEX-R55G-2326-SM-2TC61 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92157 GATA2-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-WY7C-2526-SM-3NB2N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07644 CUX1 ENCODE Transcription Factor Targets 1.0 null periventricular stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40274 GSE105173,GSE105175_1_v_0_dhx36_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AL-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUM102PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.753481 IE-38-FB31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.243786 embryo TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null dna recombination GO Biological Process Annotations 2015 1.0 null GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles 1.0 1.66509 Prostate adenocarcinoma_PRAD_TCGA-G9-6496-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TP63 ChEA Transcription Factor Targets 1.0 null CF-97-KZ12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.329122 BC-43-JW95_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.515628 ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17303 STAT5A ENCODE Transcription Factor Targets 1.0 null COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.872344 core of nucleus accumbens Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53122 organelle part GO Cellular Component Annotations 2015 1.0 null H3K4me1_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GABPA_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EVI1-22308434-SKOV3-HUMAN-OVARY-OVARIANCANCER ChEA Transcription Factor Targets 2022 1.0 null CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE138672_0_v_1_rabgef1_mouse RummaGEO Gene Perturbation Signatures -1.0 null nucleus COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GSE175787_13_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE169205_0_v_5_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null AB-71-VZ28_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.217782 POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12869_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2696-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7149-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7244323-elife-55325-supp3.xlsx-Noordermeer_TP53-KO-Gene_TP53 Rummagene Transcription Factor Associations 2026 1.0 null HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.922271 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE184892_4_v_2_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HAND1_cust_HAND1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles 1.0 2.77975 GTEX-S7SE-0011-R1A-SM-2XCDE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.905042 GSE224131_3_v_1_mafb_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CC-04-WK34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.990359 SNAPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12154 GSE178714_1_v_4_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54143 GSE158834_7_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MYOD1 ENCODE Transcription Factor Targets 1.0 null BB-49-OQ60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.227471 GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.979591 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r10 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.27779 SU8686 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.40413 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_7_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.941685 JUND_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6215_PELP1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.514103 H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1532 GSE115364_0_v_1_idh3a_human RummaGEO Gene Perturbation Signatures -1.0 null 496100498_PCx_dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.05008 POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular_component GO Cellular Component Annotations 2015 1.0 null GA-28-SS67_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.67505 CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null metabolic process GO Biological Process Annotations 2015 1.0 null H3K79me1_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A510-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE118548_1_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null BE-27-RQ61_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.288199 EE-66-CK83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202941 protein complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC9574515-mmc2.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03937 IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE65617_2_v_1_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null BC-15-EL49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.347425 CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA1_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC35F2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6209 dorsolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.12594 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV5-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE147876,GSE147877_2_v_7_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null BATF ENCODE Transcription Factor Targets 1.0 null H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SSH3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31017 MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KASUMI2 CCLE Cell Line Gene Expression Profiles 1.0 2.26036 TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r4BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11273 Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB7B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.6163 GSE247084,GSE247087_0_v_1_cdyl_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 0.910973 GSE178714_5_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles 1.0 1.8113 male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 disease of mental health GWASdb SNP-Disease Associations 1.0 0.048617 GSE217115_2_v_4_alectinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null BD-04-NG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.454483 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null NFKB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.2326 PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC Rummagene Transcription Factor Associations 2026 1.0 null GSE81803,GSE81912_0_v_5_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K79me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 7559_RRN3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.8034 MCF7_AT9283_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0128763 EFO21 CCLE Cell Line Gene Expression Profiles 1.0 1.67131 GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -4.16968 GSE214931_2_v_5_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29V-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Zileuton_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0225019 UTP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31829 reticular formation of CoPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18546 ZNF143 ENCODE Transcription Factor Targets 1.0 null MCF7_BMS-754807_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0150113 TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH810 CCLE Cell Line Gene CNV Profiles 1.0 2.88017 cuneus, left, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.44906 GTEX-WFG7-1026-SM-4LMK8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14615 7498_RPS10_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.518161 GTEX-OHPM-0326-SM-33HCA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.899407 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MIS12/MIND type complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.856 intermediate stratum of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36124 bipolar affective disorder GWASdb SNP-Phenotype Associations 1.0 0.664442 TBX5 ChEA Transcription Factor Targets 1.0 null GSE198380_0_v_1_phgdh_human RummaGEO Gene Perturbation Signatures 1.0 null CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r10 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.35436 lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09885 K562_Temsirolimus_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0146744 H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null AC-30-XU83_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214017 SOX10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.3474 pineal gland Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.893875 embryonic structure TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -3.1004 GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1 ENCODE Transcription Factor Targets 1.0 null 15474998-tableS1c GeneSigDB Published Gene Signatures 1.0 null GTEX-U3ZM-0926-SM-4DXSW GTEx Tissue Sample Gene Expression Profiles 1.0 0.827962 SG in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.48484 H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CSB-26484114-CHIP-SEQ-FIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CC-00-ZO24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.211171 H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null muscle GTEx Tissue Gene Expression Profiles -1.0 -2.10021 Ptf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 55.0351 KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.915718 Perturb_3455_KO_Mecp2_SRP017936 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.34058 superficial stratum of SePal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02544 r6 part of ventral gigangocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1345 macromolecular complex GO Cellular Component Annotations 2015 1.0 null RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 2.25677 NE-94-VE83_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.362744 PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX Rummagene Transcription Factor Associations 2026 1.0 null 7505_RPS16_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.53451 RA-27-ST16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.54438 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null 5746_NOP14_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.559947 GSE94814_2_v_0_reck_mouse RummaGEO Gene Perturbation Signatures 1.0 null ED-71-GA72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.43681 NFYA ENCODE Transcription Factor Targets 1.0 null GTEX-S4Q7-1026-SM-4AD75 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20531 9684_UTP20_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.510988 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HSP90AB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26907 H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Disulfiram_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0176609 Perturb_13502_KD_WDR5_SRP321449 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.72898 NCC010 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-BatSRBD_84Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.68964 PMC12634441-41375_2025_2771_MOESM8_ESM.xlsx-ATACseq-Table_S3_Bulk_ATAC-seq_GATA2_vs_control_Only_p-adj_0_05_GATA2 Rummagene Transcription Factor Associations 2026 1.0 null inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26584 GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65569 ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nuclear part GO Cellular Component Annotations 2015 1.0 null POU2F2 ENCODE Transcription Factor Targets 1.0 null SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 900 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.888185 1470_CEBPZ_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.579037 YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SKA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67106 GSE223893_2_v_10_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null BL1121 (SMC6) NURSA Protein Complexes 1.0 null HOP-92 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.963796 RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.868194 BICR31 CCLE Cell Line Gene CNV Profiles 1.0 1.8445 AB-64-ZX70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.627228 TCFAP2C-20176728-TROPHOBLAST STEM CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-XUW1-0826-SM-4BOP6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09228 Perturb_757_KO_DNMT3B_SRP389363 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.20351 ATF2 ENCODE Transcription Factor Targets 1.0 null H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of pedal digit skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null transition metal ion binding GO Molecular Function Annotations 2015 1.0 null H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lower (caudal) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.21915 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.17286 intermediate stratum of PcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08685 MOLM13 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.53003 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.252 Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.004 DLX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17392 dorsal lateral geniculate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1407 GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.911802 RELB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9444 H3K36me3_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null 496100631_PCx_dementia_TBI_77_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.16639 POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null granular layer of rostral dentate gyrus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.855306 GSE210682_2_v_1_methadone_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE188870,GSE188871_4_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF770 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.1066 HPAC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0616 GABPA_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60351 ARGFX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2853 H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S4Q7-0226-SM-4AD5O GTEx Tissue Sample Gene Expression Profiles 1.0 1.14768 IC-76-JU42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.440071 LHX9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4061 posterior (caudal) superior temporal cortex (area 22c)_25 pcw_F_12948 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.32126 CREB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4056 GSE180951_6_v_5_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null ventral nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36535 GSE207832_1_v_0_usp22_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-UPIC-0626-SM-4IHK2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.924571 MAX_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1478 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CENPI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15459 NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Ellagic acid_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0192714 VMRCRCW CCLE Cell Line Gene CNV Profiles 1.0 1.38233 POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE123943_4_v_0_sox1_human RummaGEO Gene Perturbation Signatures 1.0 null Superior colliculus, motor related, deep white layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16333 RUNX1 ChEA Transcription Factor Targets 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null globus pallidus, internal segment, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.13599 reticular nucleus of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.80247 primary auditory cortex (core)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12385 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11421 SARS-BatSRBD_72Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.18602 GTEX-RWSA-0626-SM-2XCBD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91187 SNAI2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.9353 molecular_function GO Molecular Function Annotations 2015 1.0 null NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.31706 YY1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ISX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2672 H3K36me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.7564 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NFYA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAL1-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null shell of T-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03991 PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE233183,GSE233187_2_v_6_larp1_human RummaGEO Gene Perturbation Signatures -1.0 null MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6004_KD_CEBPZ_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE239844_6_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null HELA Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.08358 MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.0616 C170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null STAT5A-24692510-EPITHELIUM-MOUSE-MAMMARY ChEA Transcription Factor Targets 2022 1.0 null PMC4540202-cddis2014370x2.xls-Sheet1-Table_S2_MEIS2-responsive_genes_MEIS2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WFJO-0002-SM-3P61X GTEx Tissue Sample Gene Expression Profiles 1.0 1.07932 GSE240027,GSE240030_1_v_0_atrx_mouse RummaGEO Gene Perturbation Signatures -1.0 null lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.29537 ubiquitin-protein transferase activity GO Molecular Function Annotations 2015 1.0 null 5747_NOP16_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.569205 SMC3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.35394 KASUMI1 CCLE Cell Line Gene CNV Profiles -1.0 -1.8063 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.47167 NOTO JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.5121 GATA2_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PQ-0426-SM-3NMCI GTEx Tissue Sample Gene Expression Profiles 1.0 0.911059 TIFA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09679 H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Resveratrol_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151741 GTEX-WH7G-0326-SM-3NMBH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01408 Cohesin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.988 7427_RPF2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.523004 GABPA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sox11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.803 H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DC-17-ZB19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.323381 primary visual cortex (striate cortex, area V1/17)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.82438 JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral part of alar m1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12226 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.3615 CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_PF-3845_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0162715 GTEX-WFG7-0001-SM-3P61S GTEx Tissue Sample Gene Expression Profiles 1.0 1.06288 Lateral group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06175 intermediate stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38731 GTEX-NPJ8-1326-SM-3LK6B GTEx Tissue Sample Gene Expression Profiles 1.0 0.922724 protein modification by small protein conjugation GO Biological Process Annotations 2025 1.0 null GSE169697,GSE169725_0_v_4_prrx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC12624014-41419_2025_7799_MOESM1_ESM.pdf-56-NFYC_NFYC Rummagene Transcription Factor Associations 2026 1.0 null PBX1-22567123-OVCAR3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null dactinomycin_mus musculus_gpl1261_wild type_gds2456 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null central lateral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7776 GTEX-V1D1-1926-SM-4JBGX GTEx Tissue Sample Gene Expression Profiles 1.0 1.51324 SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.0789 GSE215461_0_v_1_topotecan_human RummaGEO Drug Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.975734 mantle zone of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11911 Chromosomal region COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 SUDHL10 CCLE Cell Line Gene Expression Profiles 1.0 1.63678 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Retrochiasmatic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29929 PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-NB4-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_NB4_LYL1 Rummagene Transcription Factor Associations 2026 1.0 null IZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.82723 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A-CA-04-2009(H1N1)_36Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.99492 HNF4A ENCODE Transcription Factor Targets 1.0 null WRNIP1 ENCODE Transcription Factor Targets 1.0 null GTEX-U3ZN-0002-SM-3NMDF GTEx Tissue Sample Gene Expression Profiles 1.0 0.931094 TP53 JASPAR Predicted Transcription Factor Targets 1.0 null CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE125403_3_v_6_venetoclax_human RummaGEO Drug Perturbation Signatures 1.0 null GA-28-SS67_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.997597 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null regulation of DNA metabolic process GO Biological Process Annotations 2025 1.0 null H3K4me3_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SKNO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.95977 CTCFL ENCODE Transcription Factor Targets 1.0 null GTEX-WFON-0226-SM-3GIKR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21337 GATA1_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD7_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.844065 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BA-02-FS63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235468 TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MutLgamma complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.544 GTEX-XXEK-0926-SM-4BRWH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.853669 chromatin organization GO Biological Process Annotations 2025 1.0 null HCC1143 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.00183 PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF Rummagene Transcription Factor Associations 2026 1.0 null HNF4A-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-2392 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 MCF7_Alisertib_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.013731 H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles 1.0 1.87983 mantle zone of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13119 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVN-2426-SM-2S1Q4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997205 GSE94814_1_v_0_reck_mouse RummaGEO Gene Perturbation Signatures 1.0 null HOXB7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6099 PML ENCODE Transcription Factor Targets 1.0 null corpus callosum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28969 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HT-22 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.021 GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26369 POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13313 GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45816 A549_Divalproex Sodium_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0172584 outer SZ in posteror frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.933356 PF-59-CY33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.362941 periventricular stratum of TG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.21785 DND41 CCLE Cell Line Gene Expression Profiles 1.0 1.42561 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131887_1_v_0_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null MAX_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23795 GSE218060_1_v_0_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null A549_BMS-911543_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0172304 PMC9288051-13046_2022_2428_MOESM5_ESM.xlsx-Super_enhancers_in_T-ALL3-OVERLAP_GENES_PAX5 Rummagene Transcription Factor Associations 2026 1.0 null Bed nuclei of the stria terminalis, posterior division, transverse nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20685 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.9693 FE-82-WB22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.918326 ATF3-27146783-CHIP-SEQ-COLON-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE195503_3_v_0_progesterone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE142210_2_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K18ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248707 primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.839031 GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null positive regulation of response to stimulus GO Biological Process Annotations 2015 1.0 null SG in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.27559 DOHH-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05206 cingulate gyrus, parietal part, left, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.958074 Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A7BN-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL-27 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.31399 PMC9574515-mmc2.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null Ventral medial nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31467 GTEX-XQ8I-0626-SM-4BOPT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.917929 Post-translational protein modification Reactome Pathways 2024 1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.313 anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1439 ACHN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.89277 AKT1_activemutant_216_GSE9484 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.05443 GSE235587_2_v_0_mitoxantrone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE184884_7_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE223893_11_v_10_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null LOVO COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_GM12867_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMEM60 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28075 GTEX-QDVN-1626-SM-48TZC GTEx Tissue Sample Gene Expression Profiles 1.0 0.835667 dna metabolic process GO Biological Process Annotations 2015 1.0 null NOL8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06877 reticular formation of basal m2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71549 GSE206516,GSE206518_6_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null FOXA2-19822575-HEPG2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34024 JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216043_10_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null deep white layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.6245 MAX ENCODE Transcription Factor Targets 1.0 null hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.350333 5828_NSMCE1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.683436 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LGE-VZ border region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0363 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZC3H11A ENCODE Transcription Factor Targets 1.0 null basolateral amygdaloid nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14461 ChIP_SETDB1_19884257 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H1_BMP4_Derived_Mesendoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.867485 POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UTHO-0726-SM-3GAEN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00521 CDX2-20551321-CACO-2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Lomustine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0178134 IZ in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.91951 IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A767-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE163240_3_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.941434 BB-74-RX30_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.352188 central part of MD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43892 GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 1.67099 subcuneiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56352 7522_RPS2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.558708 SNU-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.51826 H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null dorsolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.53922 MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.669 2132_DDX56_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.599521 RCBTB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03505 hippocampus (hippocampal formation)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.924815 FA-63-WI26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.347651 CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.20609 GTEX-RWS6-0326-SM-2XCAP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1088 PMC12005766-ADVS-12-2413120-s003.xlsx-VENN1-Table_S6_related_to_Figure_S6D_List_of_overlapping_DEGs_with_the_E3_or_DUB_gene_set_from_the_iUUCD_2_0_database_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null GSE48812_8_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null H3K9me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC8185471-mmc4.xlsx-D2-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_2_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15 Rummagene Transcription Factor Associations 2026 1.0 null lateral part of JcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49125 ETV6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25065 EJM CCLE Cell Line Gene CNV Profiles 1.0 1.70305 ZE-13-SI09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.289308 SK23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20965 MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null ubiquitin-protein transferase activity GO Molecular Function Annotations 2025 1.0 null SLR20 CCLE Cell Line Gene CNV Profiles 1.0 1.86885 GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21255 TUFT1 Pathway Commons Protein-Protein Interactions 1.0 null intermediate stratum of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58563 subpretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20109 PANC0327 CCLE Cell Line Gene Expression Profiles -1.0 -1.76006 Liver hepatocellular carcinoma_LIHC_TCGA-FV-A495-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null vascular system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null 7499_RPS11_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.574075 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.1996 Brain Lower Grade Glioma_LGG_TCGA-HT-7684-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE215351,GSE215794_7_v_0_kdm8_mouse RummaGEO Gene Perturbation Signatures 1.0 null pparg_21068720_macrophage_c57bl6_lof_mouse_gpl1261_gds4370 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.311167 GSE234289_4_v_1_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null GSE193588_1_v_2_pax3_mouse RummaGEO Gene Perturbation Signatures 1.0 null A549_FLLL32_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155242 MCF7_PF-573228_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0120762 Fatty Liver CTD Gene-Disease Associations 1.0 1.19213 GTEX-WEY5-0001-SM-3P61Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.03822 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25341 SP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06046 PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.58663 GTEX-Q2AI-1526-SM-3GIJ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90109 SLC43A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34427 PACSIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00233 TENT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18282 GTEX-XLM4-2026-SM-4AT4X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.840013 TAL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC7293310-41467_2020_16179_MOESM8_ESM.xlsx-Table_S9_GATA1_WT24h_vs_SET24-Unnamed_9_GATA1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XBED-0926-SM-48TCE GTEx Tissue Sample Gene Expression Profiles 1.0 1.08873 bonemarrow_5a HPA Tissue Sample Gene Expression Profiles -1.0 -1.93068 CCNT2 ENCODE Transcription Factor Targets 1.0 null XE-69-AT35_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.314777 CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EP300_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular_component LOCATE Curated Protein Localization Annotations 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.41007 H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31471 ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF3 ENCODE Transcription Factor Targets 1.0 null RAD21_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 VSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.8907 superficial stratum of TSPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5302 GTEX-QDVN-2326-SM-2S1PF GTEx Tissue Sample Gene Expression Profiles 1.0 0.878891 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KCI-MOH1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.921172 STAT5B-24692510-EPITHELIUM-MOUSE-MAMMARY ChEA Transcription Factor Targets 2022 1.0 null HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null dorsofrontal pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08685 CADM1_KO_GDS2026_301_mouse_testis GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34379 COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.18583 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EEF1A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26535 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_IOX2_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0189659 SuperiorCervicalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.06669 SUMO2 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H2461 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.36106 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71103 PMC8185471-mmc4.xlsx-hESC-DEGs_between_SOX15_KO_hESCs_and_WT_hESCs_cells_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15 Rummagene Transcription Factor Associations 2026 1.0 null posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.867316 MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A549_Carmofur_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0146926 GTEX-OIZH-1526-SM-3NB1J GTEx Tissue Sample Gene Expression Profiles 1.0 1.30111 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CBY1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08525 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13J-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE171837_3_v_2_bortezomib_mouse RummaGEO Drug Perturbation Signatures 1.0 null FA-43-XS35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.221912 7516_RPS27A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.643203 GSE210101,GSE210114_6_v_10_urod_human RummaGEO Gene Perturbation Signatures -1.0 null H4K5ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MFE-319 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE160373_8_v_7_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null AC-84-QG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.50016 central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.81386 dna repair GO Biological Process Annotations 2015 1.0 null 496100452_HIP_possible Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.48601 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Immune system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.052 SF126 Achilles Cell Line Gene Essentiality Profiles 1.0 2.64198 NFYB ENCODE Transcription Factor Targets 1.0 null E2F1 ChEA Transcription Factor Targets 1.0 null CAL-120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.28398 TAF1 ENCODE Transcription Factor Targets 1.0 null HCC38 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.90775 GSE193541_1_v_2_nifurtimox_human RummaGEO Drug Perturbation Signatures 1.0 null GTF2B ENCODE Transcription Factor Targets 1.0 null CC-03-PW00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.280243 ZEB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-ID_AR Rummagene Transcription Factor Associations 2026 1.0 null Respiratory system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.313 MCF7_CEP-33779_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0154794 H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE178714_6_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null BC-43-JW95_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.244368 POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE154081_3_v_0_sildenafil_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LHX5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.8399 GSE210101,GSE210114_0_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null H4K5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC6345883-41598_2018_37397_MOESM10_ESM.xlsx-AR_D0_VS_D14__TRANS-Gene_Name_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PWCY-0226-SM-48TD8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.877002 GTEX-POMQ-0008-SM-48TE7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.882295 GTEX-RN64-0726-SM-48FCV GTEx Tissue Sample Gene Expression Profiles 1.0 1.0224 BA-68-FJ41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.208057 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25341 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25341 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CD71+_EarlyErythroid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.18669 H4K91ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SUMO ligase complex GO Cellular Component Annotations 2025 1.0 null striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.955877 positive regulation of biological process GO Biological Process Annotations 2015 1.0 null GABPA_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210101,GSE210114_4_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null Penis_Foreskin_Fibroblast_Primary_Cells_skin01 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 2.05278 posteroventral (inferior) parietal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16302 ZSCAN31 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.5685 KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13645 PC-18-VX23_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.33674 hippocampus (hippocampal formation)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.26938 H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE144231_3_v_1_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein metabolic process GO Biological Process Annotations 2015 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-7269-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE172490_5_v_3_junb_mouse RummaGEO Gene Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U7-06A-21R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null protein sumoylation GO Biological Process Annotations 2023 1.0 null HMGN3 ENCODE Transcription Factor Targets 1.0 null GTEX-SUCS-0526-SM-4DM56 GTEx Tissue Sample Gene Expression Profiles 1.0 0.876955 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Metabolism of proteins Reactome Pathways 2024 1.0 null SF268 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.89773 H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null STAT3 MotifMap Predicted Transcription Factor Targets 1.0 null connecting stalk TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null HCC202 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 2.31292 GSE161800_0_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 A-Vietnam-1203_CIP048_RG4-2004(H5N1)PB2-627E_4day-MOI-10^4_None_GSE43301 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.44389 nucleus LOCATE Curated Protein Localization Annotations 1.0 null GSE193402_0_v_3_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null NCIH1385 CCLE Cell Line Gene Expression Profiles -1.0 -1.58137 CTCF_fibroblast of lung_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DT-40 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.812 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QXCU-0226-SM-2TC5W GTEx Tissue Sample Gene Expression Profiles 1.0 0.964098 TAF1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T8EM-1326-SM-3DB7G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17153 peptidyl-lysine modification GO Biological Process Annotations 2023 1.0 null H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE222598_1_v_0_sf3b4_human RummaGEO Gene Perturbation Signatures 1.0 null Ventral anterior-lateral complex of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.77867 NCIH196 Achilles Cell Line Gene Essentiality Profiles 1.0 1.33694 GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDK8_knockdown_130_GSE30816 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.84338 SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.95234 GSE240027,GSE240030_5_v_3_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7459_RPL31_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.652218 superficial stratum of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79788 YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.87789 C32 CCLE Cell Line Gene Expression Profiles -1.0 -1.51502 GTEX-T2IS-0426-SM-32QPE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58971 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.51047 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 13_AARS_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.577543 GB1_CENTRAL_NERVOUS_SYSTEM CCLE Cell Line Proteomics 1.0 5.05546 7537_RPS7_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.595826 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39V-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null caudal ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.98278 ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HY-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PTK7_KD_GSE50138_674_human_H1299 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SARS-BatSRBD_48Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.80875 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XOTO-2826-SM-4B65I GTEx Tissue Sample Gene Expression Profiles 1.0 1.45779 GSE238005_0_v_3_c9orf72_human RummaGEO Gene Perturbation Signatures -1.0 null Bronchial disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.313 Cellular bud neck septin ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.638 GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 1.73196 BB-20-UU03_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.701882 CF-97-KZ12_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.219032 GSE214442_0_v_1_pak4_mouse RummaGEO Gene Perturbation Signatures 1.0 null UBE2D2 Pathway Commons Protein-Protein Interactions 1.0 null GSE178714_3_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null posterior triangular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59546 NELFE ENCODE Transcription Factor Targets 1.0 null CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CYFIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15639 GTEX-WEY5-0226-SM-3GIKN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997152 H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_unique_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null RUNX1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null retromammillary area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42412 CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD18 Pathway Commons Protein-Protein Interactions 1.0 null fallopiantube_8d HPA Tissue Sample Gene Expression Profiles 1.0 2.43252 chromosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Nuclear envelope adjacent to nuclear pore complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.462 BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE185944_0_v_3_pth1r_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE168401_1_v_3_harmine_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Capecitabine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0175405 hESC Derived CD184+ Endoderm Cultured Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.10232 CREM ChEA Transcription Factor Targets 1.0 null CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-7138-01A-41R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventral lateral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.51019 GTEX-SN8G-0008-SM-4DM4X GTEx Tissue Sample Gene Expression Profiles 1.0 0.94943 Lung squamous cell carcinoma_LUSC_TCGA-90-7964-01A-21R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 16651409-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null PSN1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12097 HNF4A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BB-62-MS83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.273286 PMC4266008-mmc3.xlsx-iPS-MSC_vs_MSC-Unnamed_7_MSC Rummagene Transcription Factor Associations 2026 1.0 null STAT1 ENCODE Transcription Factor Targets 1.0 null GTEX-OIZH-2026-SM-3NB1M GTEx Tissue Sample Gene Expression Profiles 1.0 1.1867 GSE146962_0_v_1_glucosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-Q2AH-0008-SM-48U2J GTEx Tissue Sample Gene Expression Profiles 1.0 0.91741 PMC7608835-aba3058_Table_S4.xlsx-EWS-FLI1_RING1B-Genes_containing_RING1B_EWSR1-FLI1_enhancers_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null primary auditory cortex (core)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.83308 lateral spiriform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12566 GTEX-S32W-0126-SM-4AD61 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23302 GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.98847 GSE191105_0_v_3_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null AA-99-PN83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.211545 CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null liver GTEx Tissue Gene Expression Profiles -1.0 -0.89051 Synaptonemal structure COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.843 PUR1 MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null TFAP4::FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.8327 NA-30-HS87_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.23459 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 1.56656 wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.684459 Lung squamous cell carcinoma_LUSC_TCGA-60-2706-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-1826-SM-2YUNC GTEx Tissue Sample Gene Expression Profiles 1.0 1.30167 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T5JC-1226-SM-4DM7C GTEx Tissue Sample Gene Expression Profiles 1.0 1.2429 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.33738 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE169356_2_v_1_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null Hypertension_Adrenal gland_GSE1674 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.24435 Cell Transformation, Neoplastic CTD Gene-Disease Associations 1.0 1.05312 STAT4 ChEA Transcription Factor Targets 1.0 null SETDB1 ChEA Transcription Factor Targets 1.0 null Ventral group of the dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.89538 H3K18ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE108614,GSE108615_0_v_2_setd1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null ventrolateral prefrontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.83846 GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27393 NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36691 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA1_G1E-ER4_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.33162 GSE154961,GSE154963_4_v_0_chd4_human RummaGEO Gene Perturbation Signatures 1.0 null E2F4_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ventrolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.903195 TUHR4TKB_KIDNEY CCLE Cell Line Proteomics 1.0 2.35259 7432_RPL10_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.543515 H3K56ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE126621,GSE126920_1_v_3_dppa4_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_Enzastaurin_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0149576 A-Vietnam-1203-2004(H5N1)_2day-IDO1KO_None_GSE40792 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.03608 H3K4me1_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Bed nuclei of the stria terminalis, anterior division, fusiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0771 H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A549_PFI-1_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.017567 MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF263 ENCODE Transcription Factor Targets 1.0 null PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-Hela_IRF3 Rummagene Transcription Factor Associations 2026 1.0 null FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.36326 prostate HPA Tissue Protein Expression Profiles 1.0 1.8714 H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.902208 mantle zone of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40322 4108_IMP4_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.602131 SZ in subgenual cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.96962 POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAX8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8259 PBX3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AD-66-NV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.771398 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of JcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17065 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6HZ-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XV7Q-0005-SM-4BRWI GTEx Tissue Sample Gene Expression Profiles 1.0 0.878287 Atoh1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.4869 H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle part GO Cellular Component Annotations 2015 1.0 null GSE208350_4_v_1_fgfr1_human RummaGEO Gene Perturbation Signatures -1.0 null SUMOylation Reactome Pathways 2024 1.0 null SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Superior colliculus, motor related, intermediate white layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27206 H3K9ac_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE178714_3_v_0_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null preweaning lethality, complete penetrance MGI Mouse Phenotype Associations 2023 1.0 null Perturb_12265_KD_PUS1_SRP394042 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.6522 POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFON-2026-SM-4LVMW GTEx Tissue Sample Gene Expression Profiles 1.0 1.00673 A549_SB431542_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.012851 NC-52-HX69_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.570855 SARS-CoV MA15_Day7-C57BL6_None_GSE50878 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.66191 G22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.886904 MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.35319 nucleobase-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null CTCF_fibroblast of mammary gland_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZC-12-OO11_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.215306 STAT3-19079543-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GATA1_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.51047 GTEX-X8HC-1626-SM-46MWE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.850845 GTEX-NFK9-2226-SM-3MJGP GTEx Tissue Sample Gene Expression Profiles 1.0 1.696 NCI-H2122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.936461 KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1 ENCODE Transcription Factor Targets 1.0 null GSE235066_7_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null FLI1 ChEA Transcription Factor Targets 1.0 null MKN28 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.79954 shell of SCH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52922 GTEX-WFG7-1826-SM-3GIL1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.838514 posteroventral (inferior) parietal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.32126 GSE153867_6_v_8_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null KASUMI1 CCLE Cell Line Gene Expression Profiles -1.0 -1.65919 KATO III Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.13234 Uterine Carcinosarcoma_UCS_TCGA-QM-A5NM-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.53889 MEIS1 ChEA Transcription Factor Targets 1.0 null SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.74966 intermediate stratum of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44124 GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.91355 REST_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain_Hippocampus_Middle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.07146 CEBPB-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PBX1 ChEA Transcription Factor Targets 1.0 null H3K4me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kco TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.516 GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23286 H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T6MO-0003-SM-3NMAG GTEx Tissue Sample Gene Expression Profiles 1.0 0.921298 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.869461 ventrolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02246 7513_RPS24_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.57031 A704 CCLE Cell Line Gene CNV Profiles 1.0 1.35293 GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.982722 H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null bonemarrow_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.32287 ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null GSE160817_3_v_8_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YO-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW982 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.86085 PMC9010637-mmc6.xlsx-5D-Figure_5D_Gene_Expression_Zhou_et_al_Application_of_SP3-Rox_to_identify_redox_changes_during_T_cell_maturation_SP3 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A194-01A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WM115 CCLE Cell Line Gene Expression Profiles -1.0 -2.02469 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Amisulpride_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0149753 ventrolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01362 TCF7 ChEA Transcription Factor Targets 1.0 null GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.06008 GSE168807_0_v_7_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XBEW-1426-SM-4AT4J GTEx Tissue Sample Gene Expression Profiles 1.0 0.881156 HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.954472 cell part GO Cellular Component Annotations 2015 1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r7 part of the posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41364 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hic1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.9016 ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.183365 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleus GO Cellular Component Annotations 2025 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null shell part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08509 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.853077 OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.946781 HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.900983 H3K9me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4804-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 DA-20-VR86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.656222 DAOY CCLE Cell Line Gene Expression Profiles -1.0 -1.8526 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.09556 periventricular stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85911 GSE160083,GSE160084_1_v_3_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SE5C-0626-SM-2XCDV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17385 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GA-59-RW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.80042 primary auditory cortex (core)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26041 CSRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09217 RUNX3 ENCODE Transcription Factor Targets 1.0 null CA46 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01678 7438_RPL14_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.633689 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.99993 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.900983 double-strand break repair GO Biological Process Annotations 2023 1.0 null AB-92-GP61_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222565 anteromedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3355 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.963774 FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15913 KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.254209 MDA-MB-468 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.933977 ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mesoderm TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE122215,GSE122217_0_v_2_peg10_mouse RummaGEO Gene Perturbation Signatures -1.0 null periventricular stratum of Pal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08357 NCIH1793 CCLE Cell Line Gene CNV Profiles -1.0 -1.52917 GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 1.38619 CHD1 ENCODE Transcription Factor Targets 1.0 null female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 TF-77-DW08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.659412 Lung squamous cell carcinoma_LUSC_TCGA-39-5036-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UA-06-UV98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.308023 Lung adenocarcinoma_LUAD_TCGA-49-4507-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AV-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GATA1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ZNF524 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1416 GTEX-XUZC-2126-SM-4BRW8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05017 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r4 part of medial pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11313 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.2107 GSE248045,GSE248046_0_v_1_runx1_mouse RummaGEO Gene Perturbation Signatures 1.0 null RH41 CCLE Cell Line Gene Expression Profiles 1.0 1.63125 MYOG ENCODE Transcription Factor Targets 1.0 null RELA ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5045-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 5735_NOL6_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.638435 H3K4me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SK-GT-4 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.40125 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.88847 GTEX-TML8-1426-SM-4DXUT GTEx Tissue Sample Gene Expression Profiles 1.0 0.906218 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y7-01A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRCA1_DEPLETION_GDS3791_502_human_Hela cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null STAT4-19710469-TH1 cell mouse-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74113 ventral tuberomammillary nucleus, intermediate part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58512 CTCF_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null precentral gyrus, right, superior lateral aspect of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.828786 PPARG-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null 7449_RPL23A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.692831 NFYB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4QS-1326-SM-3NMCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.16749 PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45829 DA-35-DU85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237066 Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ligase activity GO Molecular Function Annotations 2015 1.0 null SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.76336 Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.863472 TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE238005_7_v_3_c9orf72_human RummaGEO Gene Perturbation Signatures -1.0 null GSE142588_2_v_0_cinobufagin_human RummaGEO Drug Perturbation Signatures -1.0 null intermediate stratum of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0044 GSE218060_1_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE244072_10_v_3_tfeb_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary metabolic process GO Biological Process Annotations 2015 1.0 null GSE114013,GSE114014_1_v_3_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null BCP1 CCLE Cell Line Gene CNV Profiles -1.0 -2.22336 GSE147876,GSE147877_2_v_6_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null mediodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52416 PMC10828394-41698_2024_509_MOESM1_ESM.pdf-88-NRL_NRL Rummagene Transcription Factor Associations 2026 1.0 null Perturb_13803_KO_SYTL3_ERP126655 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -13.3337 GSE210101,GSE210114_11_v_3_urod_human RummaGEO Gene Perturbation Signatures -1.0 null 7501_RPS13_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.572997 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.22812 GSE149760_0_v_1_elof1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-UJMC-0226-SM-4IHLH GTEx Tissue Sample Gene Expression Profiles 1.0 0.870121 HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J9-A8CN-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AS-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.15779 ventromedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.65872 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6802 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SPI1-20517297-HL60-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MOLM16 CCLE Cell Line Gene CNV Profiles -1.0 -1.57741 RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.95625 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_7day-MOI-10^3_None_GSE44445 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.14384 CL-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.4298 GTEX-S33H-1326-SM-4AD6A GTEx Tissue Sample Gene Expression Profiles 1.0 0.885515 GTF2F1 ENCODE Transcription Factor Targets 1.0 null CEBPA-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null dactinomycin_mus musculus_gpl6246_gse21233 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null AB-43-XJ34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.252444 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null PMC5537006__F1 PFOCR Pathway Figure Associations 2023 1.0 null HCC3153 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.947578 GTEX-VUSG-0008-SM-4KL24 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02226 H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-0008-SM-4AT5M GTEx Tissue Sample Gene Expression Profiles 1.0 0.883201 SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10192 GSE147210_2_v_5_kmt2d_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62054 COLO704 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.10985 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15783 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7512_RPS23_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.622749 GB-06-BA49_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.341916 SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BA-84-TD72_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.403835 TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA-48-SW47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.06029 MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_711_KO_DNMT3B_SRP389363 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.55333 GSE178714_6_v_4_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null HOXC9 ChEA Transcription Factor Targets 1.0 null Perturb_4265_KD_CHD7_SRP160423 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.4556 r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.39335 RL Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.88564 7455_RPL27_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.19162 G22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -3.74303 K562_Tubastatin A HCl_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0188404 GSE137144_3_v_1_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null cerebellar cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.27018 Lung squamous cell carcinoma_LUSC_TCGA-70-6722-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE164529_0_v_1_tamoxifen_human RummaGEO Drug Perturbation Signatures -1.0 null SUPT20H CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1819 medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08241 dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.863921 KAT2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDX2 ChEA Transcription Factor Targets 1.0 null H3K4me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-O8-A75V-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-0226-SM-3P61I GTEx Tissue Sample Gene Expression Profiles 1.0 1.32096 PPARG-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null outer SZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13109 GTEX-WK11-0926-SM-3NMAU GTEx Tissue Sample Gene Expression Profiles 1.0 1.22244 Atherosclerosis_Aorta Smooth Muscle Tissue_GSE1560 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.7587 GSE101546_2_v_1_setdb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of PcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00636 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Q-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6344081-elife-40364-supp5.xlsx-PLZF_peaks_H3K27Ac_unchanged-Unnamed_10_ZBTB16 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer SZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01691 K562_Pirarubicin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0150986 H3K4me3_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null 2858_FAM136A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.583087 3086_FIP1L1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.556417 AB-18-YN11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.557378 GTEX-R3RS-0526-SM-3GADG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32187 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.849762 TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Asthma GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.852288 POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAGE_knockout_268_GDS3755 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.97642 mantle zone of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02993 H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC6 ENCODE Transcription Factor Targets 1.0 null GTEX-S341-1726-SM-3K2AK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98987 GTEX-SJXC-0005-SM-2XCE7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.842978 COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.972723 H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 IRF4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Transcription export complex 2 COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.219 Supraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23706 XD-44-FJ34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.681426 heterocycle metabolic process GO Biological Process Annotations 2015 1.0 null H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE128076_1_v_0_doxycycline_human RummaGEO Drug Perturbation Signatures -1.0 null GSE206729_3_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K27me3_CH12.LX_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4944136-srep28995-s2.xls-ARGFX-gene_ARGFX Rummagene Transcription Factor Associations 2026 1.0 null KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.82703 RRP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13902 fusiform gyrus, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13868 NCI-H441 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.82703 CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4U1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217132_0_v_1_pfkfb4_mouse RummaGEO Gene Perturbation Signatures -1.0 null KARPAS299 CCLE Cell Line Gene CNV Profiles 1.0 2.16659 MAFF ENCODE Transcription Factor Targets 1.0 null PMC3607232-mmc3.xlsx-b_RUNX1_SEM_MLLC_H3K4Me3-x_2_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null DE-98-FC24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.219529 EB1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.89367 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 COV362 Achilles Cell Line Gene Essentiality Profiles -1.0 -2.02438 TBX5-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE178714_5_v_7_smad2_human RummaGEO Gene Perturbation Signatures -1.0 null MCF7_Panobinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00619592 QSOX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07454 PBX3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7438_RPL14_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.522145 H4K5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14879 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PBX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XGQ4-0008-SM-4AT3Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.886773 dorsolateral TG part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.21785 496100350_FWM_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.20418 GSE169356_0_v_3_ivermectin_human RummaGEO Drug Perturbation Signatures 1.0 null FD-20-OG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.385828 GTEX-U3ZM-0226-SM-4DXTA GTEx Tissue Sample Gene Expression Profiles 1.0 0.824862 STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUYS-0002-SM-47JXL GTEx Tissue Sample Gene Expression Profiles 1.0 1.1293 TSEN15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05893 TCF7-22412390-EML-MOUSE ChEA Transcription Factor Targets 2022 1.0 null mantle zone of CoPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24918 EBF1 ENCODE Transcription Factor Targets 1.0 null AA-62-HP31_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.207576 MRPS26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98974 striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.952819 GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03201 SPG7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.49518 PMC8355885-gutjnl-2020-320652supp004.xlsx-RALY_KD_mRNA-seq-Table_3_RALY_Knockdown_in_HCT116_cells_mRNA-seq_log2_FC_1_AR Rummagene Transcription Factor Associations 2026 1.0 null Anteromedial nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18235 GSE116810_5_v_0_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NAA50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0938 Perturb_4242_KO_Sphk1/Sphk2_SRP403207 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.43886 anteroventral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21075 FA-36-VA24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.482951 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PBX3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5K1-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null testis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.08612 GTEX-XGQ4-2026-SM-4AT6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.64436 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A119-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null VCAP CCLE Cell Line Gene CNV Profiles -1.0 -1.58004 SPI1 ChEA Transcription Factor Targets 1.0 null cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00203 CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U412-0826-SM-3DB9K GTEx Tissue Sample Gene Expression Profiles 1.0 0.912434 MEIS1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Allergic disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.052 GTEX-P4QR-0726-SM-2I5GO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11966 GSE138001_0_v_3_rorb_mouse RummaGEO Gene Perturbation Signatures -1.0 null HE-16-PO98_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.406794 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPIC-0002-SM-3NMDC GTEx Tissue Sample Gene Expression Profiles 1.0 1.23398 SUMO E3 ligases SUMOylate target proteins Reactome Pathways 2024 1.0 null H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GATA2 ENCODE Transcription Factor Targets 1.0 null MCF7_ENMD-2076 L-Tartaric acid_1然_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0133688 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUW1-1326-SM-4BOO1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.945783 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.242 SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.35853 GSE121198,GSE129779_3_v_2_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null MCF7_Temsirolimus_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0120046 GSE147876,GSE147877_2_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null A549_AG-490_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0159098 PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE220520_5_v_7_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null ChIP_STAT3_19079543 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null intermediate pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16817 H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE223334_3_v_2_bcl11b_mouse RummaGEO Gene Perturbation Signatures 1.0 null FXN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47176 9366_TSR2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.643753 CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE186707_1_v_0_hdac4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Aiolos_NULL MUTATION_GDS3473_572_mouse_Bone marrow pre-BII cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11472 GSE246911,GSE246913_4_v_1_arid1a_mouse RummaGEO Gene Perturbation Signatures -1.0 null 7450_RPL23_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.648749 H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BF-22-EP86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.294555 GATA1-19941827-MEL-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MCF7_UNC1999_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0138233 MCF7_Quercetin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.019186 layer IIIa of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.35505 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Gut microbiota (bacterial taxa) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.869897 H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H1_BMP4_Derived_Trophoblast_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.93376 JHH-6 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.94117 VD-76-SO91_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.3841 GSE132386_1_v_0_ppara_mouse RummaGEO Gene Perturbation Signatures -1.0 null NSMCE4A Pathway Commons Protein-Protein Interactions 1.0 null 3t6 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.749 IRF1 ENCODE Transcription Factor Targets 1.0 null 2983_FAU_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.604829 STAT3-20064451-CD4+T-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.931181 AC-30-XU83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.610834 TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7PM-0006-SM-3NM8C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19967 H3K27ac_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FOXA1_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Asthma DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.313 Vacuolar HOPS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.075 Smc5-Smc6 complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 PMC5840266-41598_2018_22384_MOESM13_ESM.xlsx-UBE3A_KD_significant-Unnamed_23_AR Rummagene Transcription Factor Associations 2026 1.0 null Perturb_11722_KD_Poldip2_SRP303067 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.49722 GSE253089_0_v_1_ephb2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2029 COSMIC Cell Line Gene Mutation Profiles 1.0 null LYL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null cerebellum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.29456 GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles 1.0 2.54973 r7 part of cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11871 duodenum_4c HPA Tissue Sample Gene Expression Profiles -1.0 -1.08254 BB-20-UU03_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237443 GSE227592_2_v_1_adar_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_14046_KO_Bach2_SRP399450 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.61827 GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.831175 SARS-CoV_48Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -3.12848 H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null YA-78-MS95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.524605 2893_TAFA2_P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.538743 Blood TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF ENCODE Transcription Factor Targets 1.0 null GSE214931_2_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.868628 FBXO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.176 bed nucleus of the stria terminalis, laterocentral division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08249 abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50072 GSE149880_2_v_1_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null testis_7d HPA Tissue Sample Gene Expression Profiles 1.0 1.08243 GSE232786_1_v_0_otud1_human RummaGEO Gene Perturbation Signatures 1.0 null FOXO1-25302145-T-LYMPHOCYTE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.0013 PMC9941047-41591_2022_2163_MOESM3_ESM.xlsx-ST12-Unnamed_1_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null ventral posteromedial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.78621 Pancreatic adenocarcinoma_PAAD_TCGA-2L-AAQL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27076 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE201042_6_v_7_ptpmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-Q2AG-0008-SM-48U2K GTEx Tissue Sample Gene Expression Profiles 1.0 1.20975 RA-49-ZB08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.227258 cellular process GO Biological Process Annotations 2015 1.0 null intracellular organelle part LOCATE Curated Protein Localization Annotations 1.0 null HPBALL CCLE Cell Line Gene CNV Profiles 1.0 1.56609 LYL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Q7-1226-SM-4AD5I GTEx Tissue Sample Gene Expression Profiles 1.0 2.21362 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null fallopiantube_8e HPA Tissue Sample Gene Expression Profiles 1.0 1.56839 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16144 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.25791 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A549_ABT-737_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152152 CoPV part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02688 juxtacommissural pretectal domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47937 HUH1 CCLE Cell Line Gene Expression Profiles -1.0 -2.30558 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_BMS-265246_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00996385 LUDLU1 CCLE Cell Line Gene CNV Profiles -1.0 -1.42692 PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S8-DUX4_SpecDMCs-Unnamed_3_DUX4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-P4PP-0326-SM-33HC4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14105 Lung adenocarcinoma_LUAD_TCGA-49-4512-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Enzastaurin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0168637 GTEX-W5X1-0001-SM-3P61V GTEx Tissue Sample Gene Expression Profiles 1.0 0.934935 Lung squamous cell carcinoma_LUSC_TCGA-85-8479-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BD-96-HO33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.326134 H3K4me1_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.5084 Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GA-77-MH38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.557887 GTEX-U3ZN-2226-SM-3DB88 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.227 layer 3 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35709 E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null lingual gyrus, left, peristriate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17873 GTEX-OHPL-1326-SM-3MJGG GTEx Tissue Sample Gene Expression Profiles 1.0 1.22901 GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49038 GTEX-W5WG-1926-SM-4KKZK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11869 SUM149PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.845085 CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQW-0226-SM-447BJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.04906 SIHA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.884366 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06046 4349_PRORP_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.521821 GSE211262,GSE211263_2_v_1_pbrm1_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBL1XR1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE165579_3_v_2_opa1_mouse RummaGEO Gene Perturbation Signatures 1.0 null IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.34366 TA-10-KH35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209165 EA-02-ZO63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.271769 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of TG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41031 BE-31-XV38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.239021 GSE213228_4_v_3_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null BC-62-RZ55_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.420753 IC-80-CT90_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.291619 layer 1 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39128 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null OB-17-DQ74_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.360976 orbital frontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.3452 bone marrow HPA Tissue Gene Expression Profiles -1.0 -1.01785 cellular response to stimulus GO Biological Process Annotations 2015 1.0 null GTEX-WEY5-1126-SM-4LMIE GTEx Tissue Sample Gene Expression Profiles 1.0 0.917393 GSE158834_7_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BA-84-TD72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.387504 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Holliday junction resolvase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.011 MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AE-05-CB45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.34107 HUP-T3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.880833 isthmic part of basolateral isthmic reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03346 GSE172295_3_v_2_sh3gl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles 1.0 1.62934 POLR2A_K562_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hedgehog signaling complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.519 NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null m1AD (DM) part of periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38956 hippocampus BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.51471 Nerve - Tibial GTEx Tissue Gene Expression Profiles 2023 1.0 1.14978 Allergic disease (asthma, hay fever or eczema) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.530103 GSE171572_3_v_4_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_5604_KD_METTL1_SRP312040 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE189789_0_v_1_oridonin_human RummaGEO Drug Perturbation Signatures 1.0 null MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUJ4-0126-SM-4BOP7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21599 GSE227592_8_v_1_adar_human RummaGEO Gene Perturbation Signatures 1.0 null GSE120612_7_v_3_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T2IS-0008-SM-4DM75 GTEx Tissue Sample Gene Expression Profiles 1.0 0.830864 GSE199255,GSE199356_4_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null frontalcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.92127 Meiotic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.385 HNF4A ChEA Transcription Factor Targets 1.0 null abnormal spleen morphology IMPC Knockout Mouse Phenotypes 1.0 null PBX3 ENCODE Transcription Factor Targets 1.0 null SIN3B ChEA Transcription Factor Targets 1.0 null 141_ADAT3_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.536704 GTEX-P44H-0426-SM-2XCEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.974668 Foxj2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.426 STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2 Rummagene Transcription Factor Associations 2026 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7441_RPL17_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.877507 posterior orbital gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.855872 CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11938024-ADMA-37-2413413-s001.xlsx-Table_S1a_DE_Genes_analysis-Table_S1a_Differentailly_expressed_genes_Control_vs_NPs_treated_THP1_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null Myosin II filament COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.649 GATA1_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1 ENCODE Transcription Factor Targets 1.0 null GSE256181_1_v_3_etv2_human RummaGEO Gene Perturbation Signatures -1.0 null RAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5895 POU2F2_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NPJ8-0526-SM-3MJHN GTEx Tissue Sample Gene Expression Profiles 1.0 1.10419 CD59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88499 Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PANC0327 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.41224 H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZH-1126-SM-4DXUG GTEx Tissue Sample Gene Expression Profiles 1.0 0.918242 GSE182770,GSE182784_0_v_1_chd2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE87617_1_v_0_ascl1_human RummaGEO Gene Perturbation Signatures 1.0 null HOXC9-25013753-NEUROBLASTOMA-BE2-C-HUMAN ChEA Transcription Factor Targets 2022 1.0 null A549_FLLL32_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151884 GTEX-PLZ6-0626-SM-3P61B GTEx Tissue Sample Gene Expression Profiles 1.0 1.01725 GBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2203 cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.06404 paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.988202 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE138818_1_v_0_nanog_mouse RummaGEO Gene Perturbation Signatures 1.0 null increased circulating triglyceride level IMPC Knockout Mouse Phenotypes 1.0 null CW-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.31139 abnormality of the nervous system GWASdb SNP-Phenotype Associations 1.0 0.044417 Hypertrophy CTD Gene-Disease Associations 1.0 1.38043 GTEX-X88G-0004-SM-47JZ6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.872933 LNCAPCLONEFGC CCLE Cell Line Gene Expression Profiles 1.0 1.35256 PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5 Rummagene Transcription Factor Associations 2026 1.0 null ventromedial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.87211 GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 1.6259 GSE108326_1_v_0_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null heart GTEx Tissue Gene Expression Profiles -1.0 -1.15389 HDAC2 ENCODE Transcription Factor Targets 1.0 null EN1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6165 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null IRF4 ENCODE Transcription Factor Targets 1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PK1 CCLE Cell Line Gene CNV Profiles -1.0 -1.55932 striatum_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.78263 GTEX-XV7Q-0226-SM-4BRVL GTEx Tissue Sample Gene Expression Profiles 1.0 2.29231 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.25682 MBD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null bipolar disorder GWASdb SNP-Disease Associations 1.0 0.766993 GSE157894_1_v_3_cystine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AA-98-HX85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.24092 HCC4006 CCLE Cell Line Gene CNV Profiles 1.0 1.46667 CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA2 ENCODE Transcription Factor Targets 1.0 null GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03512 ETS1 ENCODE Transcription Factor Targets 1.0 null GTEX-S341-1826-SM-3K2AB GTEx Tissue Sample Gene Expression Profiles -1.0 -2.0281 H3K4me1_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GA-28-SS67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.616279 SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59053 H3K9ac_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17519 PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null GSE142019,GSE142021_1_v_3_ythdf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09846 KP3 CCLE Cell Line Gene CNV Profiles 1.0 1.35126 MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.35964 TE-87-FM14_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.205464 primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01077 SUDHL4 CCLE Cell Line Gene Expression Profiles 1.0 1.41952 H3K4me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.50381 H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHPG-2226-SM-3NMBO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08303 GTEX-TMMY-0426-SM-33HBB GTEx Tissue Sample Gene Expression Profiles -1.0 -3.17602 JHOS-2 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.77093 KNS-81-FD Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.96548 NFYB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4851 GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 0.840991 ZD-18-MI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.322225 FOXA2-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null PL-21 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.07059 Smc5-Smc6 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.45 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XE-01A-12R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A_CA_04_2009_7dayMOI-10^3_None_GSE37569 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.41368 Hyperplasia CTD Gene-Disease Associations 1.0 1.22048 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6909-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K79me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RERF-LC-MS COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null P63-20808887-KERATINOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null E2F4_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null L363 CCLE Cell Line Gene Expression Profiles -1.0 -2.62656 enlarged spleen MGI Mouse Phenotype Associations 2023 1.0 null FIZZ2_KO_GDS4902_408_mouse_Lung GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Perturb_5943_KD_POLDIP3_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.6809 K562_Entacapone_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155581 paracentral lobule, posterior part, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.925111 disease GWASdb SNP-Disease Associations 1.0 0.02465 emboliform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.921687 NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8070-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nuclear pore linkers COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.652 Perturb_1179_KD_RUNX1_ERP128097 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14181 NCI-H2452 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.17247 CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PU.1-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2978-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE215086_0_v_2_batf_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE237426_0_v_1_eif4a1_mouse RummaGEO Gene Perturbation Signatures -1.0 null rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.19759 substantia nigra, pars compacta, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.886262 1076_WDCP_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.500517 GSE188382_4_v_0_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null JUND ENCODE Transcription Factor Targets 1.0 null Perturb_1284_KD_TRIM26_ERP131496 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 ventral posterior medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.996651 A-CA-04-2009(H1N1)_24Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.54309 H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE205730,GSE205731_2_v_1_tazemetostat_human RummaGEO Drug Perturbation Signatures 1.0 null NCIH1581 CCLE Cell Line Gene CNV Profiles -1.0 -1.36489 ZNF217 ChEA Transcription Factor Targets 1.0 null GTEX-UPJH-0001-SM-3NMDE GTEx Tissue Sample Gene Expression Profiles 1.0 0.985467 VD-88-MW70_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.279444 GTEX-S4Z8-1826-SM-3K2BH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70627 TAF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KIT_activemutant_55_GSE17743 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.97745 GTEX-P4PQ-0726-SM-3NMCR GTEx Tissue Sample Gene Expression Profiles 1.0 1.53323 TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GA-28-SS67_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.947016 6534_POLR1B_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.733974 zfpm2_19411579_heart_lof_mouse_gpl1261_gds3659 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.988764 GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.65735 POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null rpmi8226 HPA Cell Line Gene Expression Profiles 1.0 2.17593 SOX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1514 FB-75-YG01_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.286513 H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE235066_4_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE160817_2_v_9_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null primary motor-sensory cortex (samples)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04857 17210682-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.43945 Origin recognition complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.663 GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.85508 regulation of chromosome organization GO Biological Process Annotations 2023 1.0 null dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.98841 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BB-74-RX30_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.288386 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE161295_0_v_1_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 outer SZ in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09582 chromosome, telomeric region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 WASHC2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21047 regulation of cellular process GO Biological Process Annotations 2015 1.0 null ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE201042_6_v_10_ptpmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5L9-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial (magnocellular) part of MD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16032 tretinoin_homo sapiens_gpl6244_gds4180 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-7631-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-dORF6_48Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.13756 IM-95M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.981362 GTEX-XV7Q-1526-SM-4BRWB GTEx Tissue Sample Gene Expression Profiles 1.0 1.01882 GTEX-QCQG-0126-SM-48U27 GTEx Tissue Sample Gene Expression Profiles 1.0 0.931519 CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_CEP-33779_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0169166 WT1-25993318-PODOCYTE-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CC2D1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.53832 EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.949448 superficial stratum of TPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30152 SAS acetyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.946 POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61474 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.929404 posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.69015 vesicle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 HB-06-WU12_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.382917 Lung adenocarcinoma_LUAD_TCGA-78-7535-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventral part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27121 Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-GeneName_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null chromosomal part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE221633_3_v_1_trim24_human RummaGEO Gene Perturbation Signatures -1.0 null GATA2-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-A492-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null substantia nigra, pars reticulata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.21871 KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.33315 preweaning lethality, complete penetrance IMPC Knockout Mouse Phenotypes 1.0 null UF-27-HS98_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.405301 PMC9574515-mmc1.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null RUNX2-24655370-MC3T3E1-MOUSE-BONE ChEA Transcription Factor Targets 2022 1.0 null GTEX-S95S-1026-SM-4B64M GTEx Tissue Sample Gene Expression Profiles 1.0 0.881339 POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE152441,GSE152442_7_v_4_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GSE210101,GSE210114_0_v_10_urod_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-SN8G-0001-SM-3NM8L GTEx Tissue Sample Gene Expression Profiles 1.0 1.28911 GSE210655_1_v_2_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null AF-99-HA02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.569118 CMC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34919 Allergic rhinitis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.052 1083_NEPRO_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.541623 NCIH2347 CCLE Cell Line Gene CNV Profiles -1.0 -1.70956 ZEB1 ENCODE Transcription Factor Targets 1.0 null Perturb_6080_KD_THRAP3_SRP271175 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 MYOD1_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA1_G1E-ER4_mm9_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null BATF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.073 NCI-H1623 COSMIC Cell Line Gene Mutation Profiles 1.0 null medial portion of the shell Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.890507 QB-99-OU03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.71061 Perturb_10223_KD_FOXC1_SRP068208 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.99433 hsa-miR-1193 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GSE213588_8_v_2_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.977819 NCI-H1770 COSMIC Cell Line Gene Mutation Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-11A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRL-0726-SM-3NM9A GTEx Tissue Sample Gene Expression Profiles 1.0 1.40667 BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.990816 KB-78-BE93_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.362085 PMC3526425-1471-2164-13-572-S3.xlsx-STAT6-STAT6_STAT6 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-2326-SM-2HMLD GTEx Tissue Sample Gene Expression Profiles 1.0 1.0891 lateral terminal nucleus of the accessory optic tract, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14839 WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD7 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2781-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE160373_1_v_7_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-1026-SM-33HBW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.859662 NFATC1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null medial superior olive Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18932 fallopian tube HPA Tissue Gene Expression Profiles 1.0 1.72729 WDR5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07382 SLR21 CCLE Cell Line Gene Expression Profiles 1.0 1.52026 Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Androgen insensitivity syndrome_Fibroblast_GSE3871 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.81663 2124_DDX47_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.580712 7515_RPS26_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.511301 caudal group of intralaminar nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.881528 Prostate adenocarcinoma_PRAD_TCGA-KK-A7B0-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -2.08165 GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.81194 CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Extrachromosomal DNA COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.168 HCC1162 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.31776 MCF7_PF-3845_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0187921 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A5UA-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-38-4625-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X4XX-0626-SM-3NMC1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03964 HCC1833 CCLE Cell Line Gene Expression Profiles 1.0 1.60581 YY1 ENCODE Transcription Factor Targets 1.0 null protein-containing complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null A549_FLLL32_1然_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0138376 GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18925 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC5 Pathway Commons Protein-Protein Interactions 1.0 null FSTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38312 STAT3-20064451-CD4+T-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GC-07-UO80_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.216825 response to stress GO Biological Process Annotations 2015 1.0 null ventral paracommissural tectal nucleus, m1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12853 STAT1 ChEA Transcription Factor Targets 1.0 null PTGR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10986 CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 48 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.873171 peptidyl-lysine modification GO Biological Process Annotations 2025 1.0 null recombinational repair GO Biological Process Annotations 2025 1.0 null NFKB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.3085 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EID3 Pathway Commons Protein-Protein Interactions 1.0 null Postpiriform transition area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30244 CTCF_cardiac muscle cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE207122_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE159148_0_v_1_sdc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYBL2 ENCODE Transcription Factor Targets 1.0 null GTEX-U3ZM-1226-SM-3DB9G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13397 K562_Hesperadin_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0168096 H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ATOH7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.8833 POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Cimetidine_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0206873 PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null cellular protein modification process GO Biological Process Annotations 2015 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-A5G7-01B-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null condensed chromosome GO Cellular Component Annotations 2023 1.0 null CREB1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null retromammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13161 GSE100316_7_v_1_mtor_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211151_1_v_0_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.285218 GSE216273,GSE216292_0_v_6_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null cytoplasmic part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 K562_RG108_10然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0221619 MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular part LOCATE Curated Protein Localization Annotations 1.0 null GSE165548_2_v_13_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null A549_Regorafenib_1然_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0146475 Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29953 H3K79me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.151075 GSE247862,GSE247863_4_v_1_eomes_mouse RummaGEO Gene Perturbation Signatures 1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null TE-87-FM14_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.208602 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null outer SZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.942698 GSE149075_1_v_4_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Precancerous Conditions CTD Gene-Disease Associations 1.0 1.04721 GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.97404 GSE144484_2_v_3_mllt6_human RummaGEO Gene Perturbation Signatures 1.0 null UBC Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CEBPB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null condensed chromosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ERA-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GD-66-XE49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.29698 HPAC CCLE Cell Line Gene Expression Profiles -1.0 -2.42039 GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886643 GTEX-TKQ2-1526-SM-4DXUN GTEx Tissue Sample Gene Expression Profiles 1.0 1.73891 PMC9314667-Table_1.xlsx-Regulons-ETV4_ETV4 Rummagene Transcription Factor Associations 2026 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null NOL11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06129 L-540 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.62361 GTEX-PLZ5-0326-SM-3P614 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10603 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.83829 male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 SP1 ENCODE Transcription Factor Targets 1.0 null GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.38582 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CAL-120 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.60707 HE-80-BQ08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.805007 CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE258991_1_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09979 GTEX-WFON-0001-SM-3P61W GTEx Tissue Sample Gene Expression Profiles 1.0 1.24338 stomach_3b HPA Tissue Sample Gene Expression Profiles -1.0 -0.918468 GTEX-X4XY-0826-SM-4E3JM GTEx Tissue Sample Gene Expression Profiles 1.0 0.873766 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.76414 posteroventral (inferior) parietal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.15036 JC-06-ED36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.281658 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ESR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.7113 H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 2.31602 NTS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02555 GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 1.41636 CBFA2T2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12324 DKMG CCLE Cell Line Gene Expression Profiles -1.0 -1.45908 YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A8CY-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IK-01A-32R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null area postrema Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15561 TCF7L2 ENCODE Transcription Factor Targets 1.0 null GSE114883_0_v_2_romidepsin_human RummaGEO Drug Perturbation Signatures -1.0 null medial part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.66752 Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96564 regulation of chromosome organization GO Biological Process Annotations 2025 1.0 null GSE248668_1_v_0_atxn1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_epithelial cell of esophagus_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE184902_3_v_0_adipor1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Vascular disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.742 GATA1_erythroblast_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LN18 CCLE Cell Line Gene CNV Profiles 1.0 2.13058 GSE211177,GSE211178_0_v_1_ets1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BB-74-RX30_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.213218 SKNFI CCLE Cell Line Gene Expression Profiles -1.0 -1.93727 DDX50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37574 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DNA damage response GO Biological Process Annotations 2025 1.0 null GSE57871_1_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null ALX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.7078 gracile nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.14874 TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEIS1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Pyramus (VIII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05707 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C1-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JEKO1 CCLE Cell Line Gene Expression Profiles 1.0 2.35251 Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RN64-0626-SM-2TC5V GTEx Tissue Sample Gene Expression Profiles 1.0 0.916826 GSE99687_0_v_1_smad5_human RummaGEO Gene Perturbation Signatures -1.0 null hydrometra MGI Mouse Phenotype Associations 2023 1.0 null GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.847294 testis_7b HPA Tissue Sample Gene Expression Profiles 1.0 1.10474 H3K36me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2YK-0005-SM-32QOV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860283 Perturb_7151_Mut_RNF43_SRP237436 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.2526 depression GWASdb SNP-Phenotype Associations 1.0 0.385832 GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.79725 8196_SMYD4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.537747 CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRKACB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06068 LBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5099 Lower respiratory tract disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.313 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null