association	dataset	threshold value	standardized value
OLIG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.2458
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2365
Thyroid gland carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.922
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.0985
Sox3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.0284
OLIG3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.0218
Platysma muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	3.24385
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.8153
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.19301
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.841378
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.975394
Larynx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.678
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7087
Purine metabolism	KEGG Pathways 2026	1.0	null
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34296
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.9194
L363	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.46222
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.8984
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0723
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00814
hsa-miR-802	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01702
USF2	ENCODE Transcription Factor Targets	1.0	null
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0116
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0732
NCIH2171	CCLE Cell Line Gene CNV Profiles	1.0	1.34925
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.43429
18849563-SuppTable5c	GeneSigDB Published Gene Signatures	1.0	null
Neuromast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.855
carbamoyl-phosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.863
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.839
FOSB::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.4355
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.94387
GSE215461_0_v_1_topotecan_human	RummaGEO Drug Perturbation Signatures	1.0	null
KURAMOCHI	Achilles Cell Line Gene Essentiality Profiles	1.0	1.04367
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.81674
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skeletal Muscle Female	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.59681
Zfp335	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.3214
Cortical surface area (min-P)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.00458
PGR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4041
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	65.0747
KDM5A	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9950457-mmc3.xlsx-GRHL2_binding_sites-RBBP8NL_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
Awn	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.202
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
XMP	MW Enzyme Metabolite Associations	1.0	null
Vertical cup-disc ratio (multi-trait analysis)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.9
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.795
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.934
KNS42	CCLE Cell Line Gene CNV Profiles	1.0	1.74797
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.832499
ABC1	CCLE Cell Line Gene CNV Profiles	1.0	1.89018
small intestine	HPA Tissue Protein Expression Profiles	1.0	0.814251
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00822
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
Vertical cup-disc ratio (adjusted for vertical disc diameter)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
CEBPB	JASPAR Predicted Transcription Factor Targets	1.0	null
QT interval (sulfonylurea treatment interaction)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.709691
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15621
Deoxyadenosine	MW Enzyme Metabolite Associations	1.0	null
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3206
COLO 679	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.89397
dTMP	MW Enzyme Metabolite Associations	1.0	null
H4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7181
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.6065
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
Deoxycytidine	MW Enzyme Metabolite Associations	1.0	null
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6677
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906611
GSE233679_14_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Childhood ear infection	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.969897
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0749
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5072
Charcot-Marie-Tooth disease X-linked recessive 5	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
NR1H4::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.4834
HCC202	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.82642
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.834767
AMP	MW Enzyme Metabolite Associations	1.0	null
OCIMY5	CCLE Cell Line Gene CNV Profiles	1.0	1.39575
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.96062
GSE109565_12_v_11_glyphosate_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Inosine	MW Enzyme Metabolite Associations	1.0	null
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07169
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00179
18849563-SuppTable3b	GeneSigDB Published Gene Signatures	1.0	null
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.36065
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH2052	CCLE Cell Line Gene CNV Profiles	1.0	2.14716
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.38519
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27005
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
HOXB2::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9933
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21372
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.136
Endocervix	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
HT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.0355
Vocal fold	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.862
NCI-H1915	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20802
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.639
SHOX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0819
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06319
H3K9me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.40955
Brain_Hippocampus_Middle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.71296
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06408
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.873
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	31.2177
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.56742
OLIG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.6905
Nicotinamide ribotide	MW Enzyme Metabolite Associations	1.0	null
hsa-miR-4692	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4156
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC2302	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.855781
GSE113005_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1195	CCLE Cell Line Gene CNV Profiles	1.0	1.63073
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
KE39	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35436
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21372
Sternum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.898
Guanosine	MW Enzyme Metabolite Associations	1.0	null
Substernal goiter	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.293
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
M059K	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07357
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.48092
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15911
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.901
Glucosidase II complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.888
NFKB1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION	ChEA Transcription Factor Targets 2022	1.0	null
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF136	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9709
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8971
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.70485
DMRT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4266
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.6363
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thyroid gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.202
TCF21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9809
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.5118
TCF4	MotifMap Predicted Transcription Factor Targets	1.0	null
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.6015
PU.1	MotifMap Predicted Transcription Factor Targets	1.0	null
A2780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.72101
ETV5::HOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6238
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.922672
Nr1h2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.468
GSE234289_4_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0477
Thyroid cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.863
Subcortical volume (MOSTest)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
SNU840	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4977
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847848
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33522
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.875
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5
17082175-Table2	GeneSigDB Published Gene Signatures	1.0	null
5'-nucleotidase activity	GO Molecular Function Annotations 2025	1.0	null
Subcortical volume (min-P)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.22218
18849563-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
impaired glucose tolerance	IMPC Knockout Mouse Phenotypes	1.0	null
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
TBX4-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
ZNF35	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.14
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.6698
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2'-Deoxyinosine 5'-phosphate	MW Enzyme Metabolite Associations	1.0	null
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.3459
heart muscle	HPA Tissue Protein Expression Profiles	1.0	0.814251
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
L1236	CCLE Cell Line Gene CNV Profiles	1.0	2.19797
496100448_TCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.29207
hsa-miR-3591-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15355
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.900375
Sperm principal piece	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.124
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.0563
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.967904
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4514	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
LAMA84	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33089
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8739
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.5279
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04613
endoplasmic reticulum	LOCATE Curated Protein Localization Annotations	1.0	null
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7221
HH	CCLE Cell Line Gene CNV Profiles	1.0	1.39284
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.858346
Hoxa11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.4916
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.989308
2-iminoacetate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.511
NFIC	JASPAR Predicted Transcription Factor Targets	1.0	null
dGMP	MW Enzyme Metabolite Associations	1.0	null
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60016
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SOX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.6316
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3165
Cortical surface area (MOSTest)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	7.6
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.1917
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1287
Cytidine	MW Enzyme Metabolite Associations	1.0	null
C32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.80899
Inner dynein arm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.517
GSE85880,GSE85881_0_v_1_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dAMP	MW Enzyme Metabolite Associations	1.0	null
NCIH1623	CCLE Cell Line Gene CNV Profiles	1.0	1.89859
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.6674
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.65239
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.70264
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Deoxyinosine	MW Enzyme Metabolite Associations	1.0	null
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.7454
Venom duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.815
Sigmoid colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33522
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.874
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-ENSEMBL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.19415
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.898668
U266B1	CCLE Cell Line Gene CNV Profiles	1.0	1.699
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.92719
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.1034
UMP	MW Enzyme Metabolite Associations	1.0	null
TFCP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6286
NCI-H2052	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.967112
GSE261563_3_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE219274,GSE219276_2_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.2442
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.173
18849563-SuppTable5b	GeneSigDB Published Gene Signatures	1.0	null
hsa-miR-4645-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.272
GSE48812_11_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06175
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	108.976
NCI-H2135	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21925
Acrosomal vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.442
HCC4017	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33744
hsa-miR-4764-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
impaired glucose tolerance	MGI Mouse Phenotype Associations 2023	1.0	null
adenosine metabolic process	GO Biological Process Annotations 2025	1.0	null
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8905
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	48.7876
GRHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2092
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.786
SAP30	ENCODE Transcription Factor Targets	1.0	null
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.43654
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.8277
GSE125219,GSE125221_4_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_6_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95302_2_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9344
Thyroid nodule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.093
HCN channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.587
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.99009
NEUROG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8115
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	85.371
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.918532
DANG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40725
gallbladder	HPA Tissue Protein Expression Profiles	1.0	2.10256
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21372
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41153
Diamine N-acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.849
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.955275
A2780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41152
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.1534
GSE145639_1_v_6_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
Atoh1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.7869
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.42645
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Right_Atrium	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.984079
BC3H1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.622
Mitochondrial inner membrane peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.039
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2717
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.863239
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3933
CEBPG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.4858
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.953956
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07169
HOXD8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0569
OVCAR8	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.35614
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23886
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18853
HCC1419	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21426
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35488
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.861
Outer dense fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.373
POLR2A	ENCODE Transcription Factor Targets	1.0	null
Rce	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.028
Anorexia nervosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
Postlarva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.157
GSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7043
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.35394
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6551
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60427
Glottis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.836
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.4564
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.0388
MKN7	CCLE Cell Line Gene CNV Profiles	1.0	1.59596
colon	HPA Tissue Protein Expression Profiles	1.0	0.814251
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
COV362	Achilles Cell Line Gene Essentiality Profiles	1.0	1.30305
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5208
HOXA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7363
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3727
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6196
HUH-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.1605
IGROV1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.95257
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.09083
hsa-miR-4328	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	0.814251
FOSL2::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.2472
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4425
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DUX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5369
rectum	HPA Tissue Protein Expression Profiles	1.0	2.10256
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.373
Retinitis pigmentosa	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.652288
NCI-H345	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17336
Lymph	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.419
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12134
BHLHA15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.0042
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
JL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.847384
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.918532
Colon sigmoideum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.834
Parathyroid gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.237
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.5774
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypoparathyroidism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.603
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.5073
ZNF768	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1245
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	43.1156
OVMANA	CCLE Cell Line Gene CNV Profiles	1.0	1.5007
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.15384
Lung	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.04506
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13391
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15257
Thyroid gland medullary carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.624
Crx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.6822
HCC1806	CCLE Cell Line Gene CNV Profiles	-1.0	-2.96845
GSE245354_6_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1719
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
ISTMES1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.72499
FOS	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.6475
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06408
GATA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.2028
KMS-28BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.91719
FADU	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41107
H3K9me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
purine-containing compound catabolic process	GO Biological Process Annotations 2025	1.0	null
BICR56	CCLE Cell Line Gene CNV Profiles	-1.0	-2.14617
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6279
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03587
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48294
increased mean corpuscular hemoglobin concentration	MGI Mouse Phenotype Associations 2023	1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906611
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.459
HCC1599	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.863239
FOS::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8553
MEOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7137
Parenchyma of thyroid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.052
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3111
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.8813
HS 766T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01126
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.256
NCIH1395	CCLE Cell Line Gene CNV Profiles	1.0	1.39466
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60719
KM12	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.55847
duodenum	HPA Tissue Protein Expression Profiles	1.0	0.814251
GSE261563_9_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.74825
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
T-cell acute lymphoblastic leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.354
CD4_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.878759
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9113
hsa-miR-499-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.44321
Sigmoid_Colon	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.871511
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.7055
THRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.2418
HT	CCLE Cell Line Gene CNV Profiles	-1.0	-2.39295
Phosphoribosylpyrophosphate synthetase superactivity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
NCIH510	CCLE Cell Line Gene CNV Profiles	1.0	1.81755
Multinodular goiter	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.436
hsa-miR-26a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.850477
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.9047
HS683	Achilles Cell Line Gene Essentiality Profiles	1.0	1.12845
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.828367
U87MG	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.42758
ATOH7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7611
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33744
Estimated glomerular filtration rate	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.8
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1756
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.33439
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01508	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.09127
NCI-H1437 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.951
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.7903
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9506
hsa-miR-4733-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	149.157
HUTU80	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.48457
HCC1954	Achilles Cell Line Gene Essentiality Profiles	1.0	1.27085
JDP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.6536
Isw1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.504
TAL1::TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4091
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12134
CatSper complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.096
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.826495
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JHESOAD1	Achilles Cell Line Gene Essentiality Profiles	1.0	1.44241
JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	68.8434
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6542
dUMP	MW Enzyme Metabolite Associations	1.0	null
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.2097
NKX6-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.5647
JUND	ENCODE Transcription Factor Targets	1.0	null
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.3473
hsa-miR-329	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
hsa-miR-3692	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33037
Deoxyguanosine	MW Enzyme Metabolite Associations	1.0	null
18849563-SuppTable3a	GeneSigDB Published Gene Signatures	1.0	null
Fascia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.419
purine nucleotide metabolic process	GO Biological Process Annotations 2025	1.0	null
PKNOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4209
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.2755
Xanthosine	MW Enzyme Metabolite Associations	1.0	null
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.8537
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03817
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.87744
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0272
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
FOXL1	JASPAR Predicted Transcription Factor Targets	1.0	null
Sperm connecting piece	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.666
FOSL2::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.8883
Six4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.2913
EFO21	CCLE Cell Line Gene CNV Profiles	-1.0	-2.50765
NCIH526	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59038
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.8428
CMP	MW Enzyme Metabolite Associations	1.0	null
HOXB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8973
Ventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.166
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.885723
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.49492
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.21915
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49618
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15355
NCI-H2106	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.895924
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	45.286
496100421_PCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.78795
KYSE-520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95309
BC3C	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42022
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13774
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.26975
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CEBPD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6756
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Stomach Smooth Muscle	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.37457
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
Laurence-Moon syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.801
IPC-298	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0083
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.967904
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15257
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23221
Neck	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.093
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.372
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	121.092
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.878718
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sperm midpiece	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.716
EHF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.6101
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BARHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.8523
Uridine	MW Enzyme Metabolite Associations	1.0	null
BARHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8482
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4966
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.1588
GID complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.525
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.8827
Thymidine	MW Enzyme Metabolite Associations	1.0	null
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.865347
SK-N-SH	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07517
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.3377
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33744
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ELK4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5854
9+2 motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.368
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.3911
BICR 10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.83808
Median body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.074
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5-nucleotidase	InterPro Predicted Protein Domain Annotations	1.0	null
CA SKI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0493
Jugular vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.187
H3K36me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
Reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.565
JHOS4	CCLE Cell Line Gene CNV Profiles	1.0	1.90299
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.0001
KYSE30	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.3963
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.978477
NCIH2228	CCLE Cell Line Gene CNV Profiles	-1.0	-2.12042
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21372
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05915
MDA-MB-231	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00822
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0531
increased mean corpuscular hemoglobin concentration	IMPC Knockout Mouse Phenotypes	1.0	null
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOSL1::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.242
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.9983
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.989044
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33744
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5981
ZNF24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.8814
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.644
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Pituitary gonadotropin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.549
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.9921
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.93904
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6788
NCI-H1623	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
Thyroid gland follicular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.884
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.995002
Deoxyuridine	MW Enzyme Metabolite Associations	1.0	null
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9614
HCC12	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27005
Autoimmune disease of endocrine system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.632
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6207
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.59303
GSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1481
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27454
Brain morphology (min-P)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.904576
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49618
HCT 116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06691
AMO1	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.2467
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K36me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0792
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.911184
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5467
H3K36me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2228	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.923314
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ISL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2276
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2477
Thyroid gland adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.88
KLF13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4465
PANC0327	Achilles Cell Line Gene Essentiality Profiles	1.0	1.61877
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11509
hsa-miR-3187-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.0421
Portio vaginalis cervicis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.781
Psammoma body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.652
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.1415
Creb5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.0241
PMC6299095-41389_2018_108_MOESM4_ESM.xlsx-T47D-TRPS1_peak-gene_symbol_TRPS1	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH69	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49691
Bulimia nervosa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.387
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0856
Sternocleidomastoid muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.593
HS 683	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.999416
Psammomatous meningioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.652
TCF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.278
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7883
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.2113
GSE233679_6_v_11_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9828
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9064
Lung function (FEV1/FVC)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.5
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.2085
COV413B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72808
IMP	MW Enzyme Metabolite Associations	1.0	null
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4263
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypoglossal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.118
HS 255.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.887673
T98G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.953956
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
Nodular goiter	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.391
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3571
NCI-H1155	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27005
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.43137
cytoplasm	LOCATE Curated Protein Localization Annotations	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.4526
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.885784
purine nucleotide catabolic process	GO Biological Process Annotations 2025	1.0	null
LNZ308	Achilles Cell Line Gene Essentiality Profiles	1.0	1.76968
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.918532
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9186
MKN45	CCLE Cell Line Gene CNV Profiles	-1.0	-1.83799
Chromatoid body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.538
Papillary carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.573
SMAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8005
Dendritic spine neck	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.732
hsa-miR-4690-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.630103
ZNF274	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5488
ETV2::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.4984
Nicotinic acid mononucleotide	MW Enzyme Metabolite Associations	1.0	null
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.927354
SNU-719	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847848
Phrenic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.106
ATF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6106
HCC2935	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.23416
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.91441
HCC95	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54731
hsa-miR-3145-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.1584
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SUPHD1	CCLE Cell Line Gene CNV Profiles	1.0	1.57158
GSE128099,GSE128159_3_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.65991
FOSB::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.417
PAX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.624
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-SYMBOL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH1792	Achilles Cell Line Gene Essentiality Profiles	-1.0	-2.52394
FOSL2::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.6373
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.860049
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4434
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6842
NCI-H1694	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
nucleus	GO Cellular Component Annotations 2025	1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.44874
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0596
ONECUT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9298
hsa-miR-410	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.261
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.5739
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3001
G142	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11115
Estimated glomerular filtration rate in non-diabetics	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0301
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.80633
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2773
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.96081
hsa-miR-26b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
T98G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.876371
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19268
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.5926
Adenosine	MW Enzyme Metabolite Associations	1.0	null
hsa-miR-4795-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Sperm flagellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.376
hsa-miR-3658	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
ZBTB6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.7351
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.15
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07328
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3467
Gizzard	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.192
Cortical thickness (MOSTest)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.969897
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	66.9472
Laryngeal cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.049
UM-UC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06398
hsa-miR-338-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.9746
MDAMB415	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62148
Systolic blood pressure	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.1699
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE57871_6_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE114883_1_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CORL23	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.82708
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.953956
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.91719
chr2_18584890_G_T_b38	GTEx eQTL 2025	1.0	2.51714
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8396
AMO-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.93899
SNU-484	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.871056
Berry	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.883
Hereditary spastic paraplegia 45	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.151
appendix	HPA Tissue Protein Expression Profiles	1.0	0.814251
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Psp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.013
PMC8684775-CTM2-11-e640-s002.xlsx-Sheet1-Table_S3_MAF_file_of_the_CCS_samples_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
SK-N-DZ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.984519
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.7654
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.3636
Manchette	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.566
Trachea	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.554
FOSL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.5955
HOXB8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.9831
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6247
BICR22	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99667
BEN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.887673
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.959825
hsa-miR-4733-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.1996
BICR 10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.05577
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.9279
GSE148321,GSE169423_0_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6994
H3K9me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC1500	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53179
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	75.4438
NT2/D1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.78
ABC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.848727
NIHOVCAR3	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.11911
COLO 320DM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.928828
HSF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7722
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	109.521
Sperm flagellum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.468
hsa-miR-664	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BACH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9141
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2531
PMC6599263-13073_2019_654_MOESM2_ESM.xlsx-CAR1_tsv-gene_name_NR1I3	Rummagene Transcription Factor Associations 2026	1.0	null
Head muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.155
NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6022
OVSAHO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00822
Throat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.145
Sperm fibrous sheath	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.788
TBX2-33478486-IMR90-HUMAN-LUNG	ChEA Transcription Factor Targets 2022	1.0	null
hESC Derived CD184+ Endoderm Cultured Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.905759
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.1662
KYSE510	Achilles Cell Line Gene Essentiality Profiles	1.0	1.01834
COLO741	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.05936
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.6291
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0882
AP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Goiter	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.51
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.7127
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	100.437
VMRCLCD	CCLE Cell Line Gene CNV Profiles	1.0	1.65743
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26154
NCIH1385	CCLE Cell Line Gene CNV Profiles	1.0	1.42203
HOXB7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.2774
hsa-miR-1297	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
MKN-45	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.80223
GMP	MW Enzyme Metabolite Associations	1.0	null
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	165.56
HT-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE152699,GSE152723_0_v_1_vemurafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOS::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1605
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.858346
HS 940.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.973339
nucleotidase activity	GO Molecular Function Annotations 2025	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
D-Ribosylnicotinate	MW Enzyme Metabolite Associations	1.0	null
Bulimia nervosa	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.7
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.1147
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0504
Thyroid cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.324
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.2115
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.106
REC1	CCLE Cell Line Gene CNV Profiles	1.0	2.19637
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.47087
H1 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.879591
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.54318
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.993
BXPC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20802
H3K9me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.91
COV413A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.76197
H3K14ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6036
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.8766
Pontocerebellar hypoplasia type 9	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.538
HS729	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6701
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.7754
CEBPB	ENCODE Transcription Factor Targets	1.0	null
ATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.251
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.7133
NCIH1694	CCLE Cell Line Gene CNV Profiles	1.0	2.59987
hsa-miR-4465	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
HCC202	CCLE Cell Line Gene CNV Profiles	1.0	1.38994
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6119
Lung function (FEV1)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.05229
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HESX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7324
NCI-H920	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23718
20220088-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
HSF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3134
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06408
nucleotide catabolic process	GO Biological Process Annotations 2025	1.0	null
Nicotinate and nicotinamide metabolism	KEGG Pathways 2026	1.0	null
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0453
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.91441
Pyrimidine metabolism	KEGG Pathways 2026	1.0	null
hsa-miR-362-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.95309
Thyroid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.182
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.7127
GSE221101_1_v_0_hopx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Differentiated thyroid gland carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.88
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.863239
GSE233679_6_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.795
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9532
purine ribonucleoside metabolic process	GO Biological Process Annotations 2025	1.0	null
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.36775
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14303
Nanog	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.1498
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07517
HOXA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1808
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.869
Columnar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.274
MCF10DCIS.COM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.906611
GP2D	Achilles Cell Line Gene Essentiality Profiles	1.0	2.57876
hsa-miR-4673	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.9505
LXF289	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32093
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
cytoplasmic part	LOCATE Curated Protein Localization Annotations	1.0	null
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5969
SKNBE2	CCLE Cell Line Gene CNV Profiles	1.0	1.52694
hsa-miR-590-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	87.9475
dCMP	MW Enzyme Metabolite Associations	1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.47904
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.41414
LS 180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.55163
18794137-SuppTable1c	GeneSigDB Published Gene Signatures	1.0	null
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
Motile cilium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.26
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.5865
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41153
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.0179
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.7937
HEC1A	Achilles Cell Line Gene Essentiality Profiles	-1.0	-1.10137
Brain morphology (MOSTest)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.969897
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8072
hsa-miR-4528	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.02734
HN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00179
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Parathyroid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.814
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06408
Diverticular disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.739794
Nicotinamide-beta-riboside	MW Enzyme Metabolite Associations	1.0	null
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.828746
LMX1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4413
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Autoimmune thyroiditis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.953
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.6114
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.314
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
KYSE150	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46247
UT7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.94898
GSE133661_0_v_1_c19orf12_human	RummaGEO Gene Perturbation Signatures	1.0	null
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.0048
GSE195503_3_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.953956
Eht	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
CEBPB_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DU4475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.962962
TEN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76409
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7542