association	dataset	threshold value	standardized value
IZUMO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05076
BRD-K20157822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09632
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0260862
BRD-K87878529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22138
BRD-K77354700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07389
K562_ENMD-2076 L-Tartaric acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222159
BRD-K62294866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8198
Anterior horn cell disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.451
GSE217405_3_v_2_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5664
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242127
BRD-K44086628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0275
BRD-K74109014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15142
BRD-K70127757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07994
BRD-K82019575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13451
Kidney Failure, Chronic	DisGeNET Gene-Disease Associations	1.0	null
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73489
BRD-K30121969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58169
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4456
BRD-K50287215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07375
BRD-K76492619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21747
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268915
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.39029
BRD-K35240878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05735
NLS-dependent protein nuclear import complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.002
OV90	DepMap CRISPR Gene Dependency	1.0	3.40355
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.67475
GSE211286_7_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8025
CRCGN011_HEPG2_24H:J13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45315
BRD-K50716325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25571
CRCGN015_MCF10A.TP53.M_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23855
BRD-K67120755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14681
10478_ZNF585A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.529894
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_1_BioID_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
JA-26-YQ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.363311
GSE242199_2_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K23361743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10641
BRD-K90562751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04577
BRD-K27671601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14966
Transport of Ribonucleoproteins into the Host Nucleus	Reactome Pathways 2024	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-D1-D3_643_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Pericycle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.802
GSE159678_4_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4204
HCC1395	DepMap CRISPR Gene Dependency	1.0	3.18889
pb1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.208
EFM19	DepMap CRISPR Gene Dependency	1.0	4.36451
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.54228
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K27982554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53611
BRD-K72609226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60214
Transcriptional regulation by small RNAs	Reactome Pathways 2024	1.0	null
BRD-K45190659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48883
PKDCC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22494
BRD-K96651591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12338
Foxl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.2744
TRIM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32738
ZNF792	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19624
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88317
CRCGN017_MCF10A.WT.HP_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.51005
BRD-K74150320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15317
BRD-K27597444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08373
JURLMK1	DepMap CRISPR Gene Dependency	1.0	2.30882
BRD-K67980271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21027
K562_Tofacitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222173
BRD-K60429174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6575
BRD-K98145661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20481
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.2918
ZNF597	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20982
ZNF316	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03735
BRD-K00685640	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1822
GSE88819_1_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DTX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64421
BRD-K11269634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18176
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62707745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09655
CRCGN017_MCF10A.TP53.M_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09438
BRD-K92134254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89147
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0575
BRD-K32723442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50849
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.72141
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K65107903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03273
KPL1_BREAST	CCLE Cell Line Proteomics	1.0	2.60076
Gene Silencing by RNA	Reactome Pathways 2024	1.0	null
7566_RRP7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.665818
K562_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180214
BRD-A20463452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52826
BRD-K21648400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23428
K562_Cediranib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0225694
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-Embryo-Hatchling_1272_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Vpr-mediated nuclear import of PICs	Reactome Pathways 2024	1.0	null
BRD-K80290360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81919
BRD-K88934376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04023
BRD-K51399866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02752
Hemochromatosis	DisGeNET Gene-Disease Associations	1.0	null
Dense fibrillar component	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.555
BRD-K76713927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04792
BRD-K14533399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37653
Respiratory system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.819
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39047
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02659
BRD-K25649458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01482
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K76154866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90947
HF-00-QG19_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.488174
Interferon Signaling	Reactome Pathways 2024	1.0	null
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	69.2835
BRD-K20585111	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05108
BRD-K50474387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98547
BRD-K23204256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1802
BRD-K04712840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03086
BRD-K27540772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59914
BRD-K69349031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17505
BRD-K19142902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.61401
GSE184479_3_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184426
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1065
BRD-K84788922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0044
ELP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0477
BRD-A20182314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70076
6239_PFDN4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.505811
BRD-K60638204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22858
BRD-K92725027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02582
BRD-A38066207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63183
GSE239844_6_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148066,GSE157787_9_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3419980-leu201249x6.xls-RUNX1-DHS-1000bp-Unnamed_0_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
N1-S1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.577
Foxf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.5905
PMC7587013-GLIA-68-2613-s005.xlsx-ASCL1_Putative_Targets-Overlapping_Genes_ChIP-seq_8791_ASCL1_Assoc_Genes_vs_TCGA_RNA-seq_2136_Top_10_ASCL1-positively_Correlated_Genes_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.144071
Tcf21	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.5087
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.540754
CRCGN015_MCF10A.WT.HP_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05688
GSE244730_0_v_1_erlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K70856965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.56174
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
ARGFX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10864
BRD-A20018680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04103
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237271
CDC42EP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11531
WC-59-RG09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305307
COLO792	DepMap CRISPR Gene Dependency	1.0	6.72895
GSE128844_0_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TMX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23076
FNBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2048
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5576
MFSD14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27385
GSE167224,GSE168147_1_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K37866276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25314
GSE239844_7_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IGSF9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10287
BRD-K96384208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41754
BF-94-CQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331786
PMC8563805-41598_2021_858_MOESM2_ESM.xlsx-Supplementary_Info_8-Gene_List_8_The_list_of_human_orthologs_of_the_downregulated_fly_DEGs_identified_from_PARIS_C571A_mutant_vs_PARIS_wild_type_comparison_ZNF746	Rummagene Transcription Factor Associations 2026	1.0	null
GSE215351,GSE215794_1_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K97540907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37326
BRD-K89110518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32321
Glycolysis	Reactome Pathways 2024	1.0	null
BRD-K42849858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05149
KMS26	DepMap CRISPR Gene Dependency	1.0	4.89014
nuclear export	GO Biological Process Annotations 2023	1.0	null
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.672171
PMC11938024-ADMA-37-2413413-s001.xlsx-Table_S1a_DE_Genes_analysis-Table_S1a_Differentailly_expressed_genes_Control_vs_NPs_treated_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K47536398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70093
MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
TGBC52TKB	DepMap CRISPR Gene Dependency	1.0	5.09101
A549_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182952
Urinary bladder	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4527
BRD-K57902040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62174
BRD-K29969800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60304
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K18109695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37456
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.92764
BRD-K30655307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43953
TFAP2A-35110662-HEPM-HUMAN-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2717
MIS18BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08338
AR-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
K562_FLLL32_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014516
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Initial pursuit acceleration	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.51549
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33458
BRD-A35931254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01009
Cell Cycle	Reactome Pathways 2024	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7944
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20_vs_D1_815_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Tuber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.099
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.3834
GSE248858_1_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NP5	DepMap CRISPR Gene Dependency	1.0	2.02881
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0943
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYBL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7397
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50287
HOXD12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7026
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE165689_0_v_1_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE248858_4_v_7_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
94T778	DepMap CRISPR Gene Dependency	1.0	3.01431
RVH421	DepMap CRISPR Gene Dependency	1.0	2.16655
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K96945047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67982
GSE229973_4_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Primary hyperoxaluria type 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
Petiole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.101
K562_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175758
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140287
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224938
Rectum cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49002
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5483
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.450065
JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6867
GSE155800_1_v_0_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
LPS6	DepMap CRISPR Gene Dependency	1.0	4.8398
NHLRC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50583
mRNA cap binding complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.688
BRD-K05479183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11042
Human brain microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.94
BRD-K90965240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74625
CENPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60824
OE-91-GF88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.404645
Foxo1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.7333
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.22538
BRD-K03599766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23706
ZNF573	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32059
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.125
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K34677894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68762
GSE77108_4_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154767_2_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49872883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1452
Female reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.142
FBN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20496
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.86465
BRD-K82863660	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87304
BRD-K35799753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90418
CRCGN016_MCF10A.TP53.M_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15201
histamine-gated chloride channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.806
PDPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0123
JUN-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
chr7_23211209_T_C_b38	GTEx eQTL 2025	1.0	1.06282
BE-69-RD44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.362145
BRD-K40532221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45315
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K79562803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89165
2313_DNM2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.612354
CRCGN016_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46922
PMC12381255-41389_2025_576_MOESM3_ESM.xlsx-Differentiated_SRCAP-1879-Gene_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
LIN28B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09133
RBM27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30643
GSE153064,GSE153065_1_v_2_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Arthrogryposis multiplex congenita	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.018
Chronic obstructive pulmonary disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.722185
PMC12019345-41598_2025_98989_MOESM10_ESM.xlsx-Sheet_1-CCNE2_related_genes_AND_HNSCC_HNSCC_DDP_NOT_DDR_Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC10290283-biol-2022-0622-sm3.pdf-389-ZNF114_ZNF114	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95350313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31171
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.39985
NCIH1573	DepMap CRISPR Gene Dependency	1.0	5.16834
UC-00-QA88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270905
K562_Fulvestrant_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155435
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9849
BRD-K30632097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70072
GSE173578_1_v_0_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303975
BRD-K89471250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30408
BRD-K19020285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48567
CRCGN011_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4342
FOXI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13464
GSE136622_2_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K60848736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91736
Heterochromatin island	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.619
GSE102467_3_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.388
GSE168797_1_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE185139_1_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75618633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63089
GSE180185_7_v_1_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nuclear pore outer ring	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.99
GSE175787_5_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A38359809	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18026
BRD-K58194737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99832
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-Genes_with_ATF3_combined_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0881
ZC3H7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40007
CRCGN015_MCF10A_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0327
SARS-CoV Infections	Reactome Pathways 2024	1.0	null
BRD-K98969488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82917
CRCGN017_MCF10A.WT.HP_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3239
BRD-K75738997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01811
Transcription export complex 2	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.723
nuclear transport	GO Biological Process Annotations 2023	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206406
ESS1	DepMap CRISPR Gene Dependency	1.0	2.23643
GSE112761,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62072978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22756
GSE108614,GSE108615_0_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68424387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19703
BRD-K39037393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0351
A549_Ofloxacin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130509
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_6_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
786O_KIDNEY	CCLE Cell Line Proteomics	1.0	4.92864
BRD-K51185182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25658
BRD-K03351377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01045
CRCGN015_MCF10A.TP53.M_24H:I15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0131
BRD-K70695911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13079
PMC2866657-pone.0010547.s003.xls-ESE3_corr-Genes_correlated_anticorrelated_to_ESE3_EHF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62935946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58421
BRD-K43282617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31296
HCMV Early Events	Reactome Pathways 2024	1.0	null
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.848839
CRCGN017_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5438
NCIH82	DepMap CRISPR Gene Dependency	1.0	6.31803
protein export from nucleus	GO Biological Process Annotations 2025	1.0	null
CRCGN014_HEPG2_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62949
nucleus	GO Cellular Component Annotations 2023	1.0	null
9689_UVRAG_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.510898
ES1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.96824
BRD-K94196749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44106
BRD-K99446825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35793
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5493
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160383
Olfactory receptor neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.171
K562_Celecoxib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232306
BRD-K60713831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32888
SW954	DepMap CRISPR Gene Dependency	1.0	5.12941
Nucleocytoplasmic transport	KEGG Pathways 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09338
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6744
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cellular response to heat stress	Reactome Pathways 2024	1.0	null
PMC8724844-bt-30-1-98-supple2.xlsx-GO_BP-SP1_SP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_8_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148200_0_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91696235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35925
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36564
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18562847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78726
BRD-K20897375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59625
GSE93309_5_v_3_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176008_8_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Immune System	Reactome Pathways 2024	1.0	null
PMC8530322-pone.0258316.s002.xlsx-GG_776_TH17-AA_776_TH17-Symbol_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K81372179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17225
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169205_3_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JMSU1	DepMap CRISPR Gene Dependency	1.0	6.07927
BRD-K20028052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11183
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.8034
HELZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19474
BRD-K96057608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10385
GSE88819_1_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_BMS-911543_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186767
BRD-K35324337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50785
K562_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189479
Diabetes	DisGeNET Gene-Disease Associations	1.0	null
BRD-K67525206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.18393
Squamous cell carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.71
BRD-K94647035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62757
BRD-K15202679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48547
PMC7553775-elife-61287-supp1.xlsx-Muller_2014_DREAM_bound_genes-Genes_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K58644442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66818
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K74933734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68749
9226_TRAF2_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.508789
BRD-K22988729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66108
Multiple synapse bouton	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.891
8305C	DepMap CRISPR Gene Dependency	1.0	2.04691
BRD-K83670600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.66033
HIV Infection	Reactome Pathways 2024	1.0	null
AFG3L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47501
A549_Thiotepa_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020083
RPS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6752
BRD-K12593465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56226
BRD-K03542527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72876
HOXB13-26457646-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE151782_3_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Mating projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.943
Endometriosis	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.142
BRD-K18004653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64944
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.24
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2446
BRD-K56441027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28725
Xylem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.069
BRD-K15620114	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41967
CRCGN016_MCF10A.TP53.M_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30463
CRCGN016_MCF10A.WT.HP_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4409
GSE136622_0_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203308_1_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE246335_4_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
Nerve ring	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.923
BRD-K84745303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27512
BRD-K50941255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95071
K562_Lapatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193902
BRD-K88739137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05031
CRCGN015_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5639
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166696
K562_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0124686
eNoSc complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.559
BRD-A31576716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76593
BRD-K37308886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26178
CDC26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21925
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3981
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
exon-exon junction subcomplex mago-y14	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.835
Nucleoplasmic side of nuclear pore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.101
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
Rev-mediated nuclear export of HIV RNA	Reactome Pathways 2024	1.0	null
Proteasome core complex, alpha-subunit complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.037
BRD-K63468420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56711
GSE241402_0_v_1_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Haustorium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.665
BRD-K42181022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5321
Metabolism	Reactome Pathways 2024	1.0	null
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21976
BRD-K18290923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25761
GSE112365_0_v_1_sirt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81006490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24551
BRD-K10232513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77089
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K74598339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02559
BCAP31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22101
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.525997
SCH	DepMap CRISPR Gene Dependency	1.0	3.8253
K562_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161197
BRD-K00048155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55239
protein export from nucleus	GO Biological Process Annotations 2023	1.0	null
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.819
Late Phase of HIV Life Cycle	Reactome Pathways 2024	1.0	null
CRCGN015_MCF10A.TP53.M_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14685
Metabolism of RNA	Reactome Pathways 2024	1.0	null
ZNF584	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48707
K562_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189881
CRCGN015_MCF10A_48H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.47731
TGFBI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66591
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222807
PMC9753996-jci-132-160767-s182.xlsx-IRF4_assciated-ABCA7_IRF4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D3REFED24h_1198_AR-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Neonatal respiratory failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.516
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.05945
FST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04343
AS3MT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55708
SPDYE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37011
BRD-K12929741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46583
BRD-K71631414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53322
BRD-K03916755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56829
AA-46-GL76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233789
FOXA1-33576154-HUMAN-LIVER-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9079
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43375
5905_NUP42_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.625145
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.819
CRCGN015_HEPG2_48H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40804
CRCGN013_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.07174
GSE111247_14_v_6_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K91120514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38653
GSE93309_1_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K24422491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78683
Cytokine Signaling in Immune system	Reactome Pathways 2024	1.0	null
PMC11956947-media-4.xlsx-C_GSEA_gene_sets-TGAYRTCA_ATF3_Q6_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K24206299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07437
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.70977
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08463
MM160113	DepMap CRISPR Gene Dependency	1.0	2.38595
BRD-K12864860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17859
BRD-K59239787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29634
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.560423
BRD-K19183365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30322
BRD-K67408816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63599
HOXB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2673
496100509_HIP_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.42764
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6074
SRP19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10197
BRD-K78288885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10149
BRD-K42455540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30488
BRD-K74860368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23024
BRD-K77718491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59776
BRD-K09227140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09603
Plant cuticle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.587
BRD-K17686226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33377
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.95286
GSE229468,GSE229471_0_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K77787814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22422
Perilymphatic space	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.558
K562_Thalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.022736
ZNF875	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24823
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6771
WDR5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34487
BRD-K20138377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14597
PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K08753635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98156
PMC11867302-mmc4.xlsx-Table_S5-Table_S5_Single-cell_transcriptome_differential_gene_analysis_DEG_results_for_all_of_our_potential_causal_genes_analyzed_by_MR_and_colocalization_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77181307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16894
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K46412655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78712
SUMOylation of chromatin organization proteins	Reactome Pathways 2024	1.0	null
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K19103068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3076
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	62.1906
BRD-K73025859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29648
SARS-CoV-2 Infection	Reactome Pathways 2024	1.0	null
Transcription factor TFIIH holo complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.102
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Flower stalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.649
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.639315
BRD-K97939219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04612
WD-62-UB45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.492298
BRD-K31503053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17135
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.86704
SMARCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08447
BRD-K75842461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.65823
PMC3874167-supp_gkt849_Supplement_Table_S1.xls-DREAM_-_TSS_clearly_affiliated-Gene_name_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K12571248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24437
FAM170A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04676
496100483_FWM_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.23947
MYC-22102868-CA46-HUMAN-BLOOD-BURKITTSLYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
AC-44-UR36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260091
BRD-K11010670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20028
BRD-K64026092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29962
DD-43-WW40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243443
K562_PJ34_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198607
GSE155031_5_v_1_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nuclear membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.476
BRD-K64953645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7521
BRD-K05286676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26971
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3472
Influenza Viral RNA Transcription and Replication	Reactome Pathways 2024	1.0	null
Transcription factor TFIIIC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.594
POLR1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2518
BRD-K02362691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25263
BRD-K67090705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55012
BRD-K60719499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.67013
TMK1	DepMap CRISPR Gene Dependency	1.0	2.87598
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.01249
BRD-K41875112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07367
BRD-K35001076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89294
BRD-K67979704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00453
PTPN21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21247
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K02809100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34328
GSE130081,GSE130082_4_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GCN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11328
CRCGN016_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05428
BRD-K41709602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06107
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13202
LMBR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25366
SULF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10736
Symbiosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.823
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.741844
BRD-K84457681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27177
BRD-K03659510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29398
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K08006576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98939
FOXA1-26457646-LHSAR-HUMAN-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K85821470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8792
Plant tumor tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.565
Leaf disc	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.95
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1805
BRD-K16496880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35658
PMC7169781-TRA-18-362-s005.xlsx-IRF3_Translocation-Gene_Name_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE93309_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28615
STRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38012
GSE220520_5_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.146
GSE233647_4_v_6_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uric acid urolithiasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-27-RQ61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225196
M07E	DepMap CRISPR Gene Dependency	1.0	3.84327
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.254
Interactions of Rev with host cellular proteins	Reactome Pathways 2024	1.0	null
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0296995
ZNF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59734
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.21705
BRD-K18558473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26227
BRD-K90111788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49167
CCNYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29645
HCMV Infection	Reactome Pathways 2024	1.0	null
BRD-K32706281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20842
BRD-K99220724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31337
BRD-K28258038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0072
CRCGN017_MCF10A.WT.HP_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0982
JAR	DepMap CRISPR Gene Dependency	1.0	2.21012
GSE135352_2_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
8288_SOX2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.604576
PMC7825356-8844261.f3.docx-33-ZNF695_ZNF695	Rummagene Transcription Factor Associations 2026	1.0	null
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.50549
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
Stele	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.043
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.44555
PMC12695649-41588_2025_2389_MOESM2_ESM.xlsx-GATA6_RIME-_AsPC-1-Gene_Symbol_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
MYC-28411283-MDA231-LM2-4175-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
Preribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.192
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PAPOLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59217
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
Lef1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.2044
CRCGN016_MCF10A.WT.HP_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55116
Regulation of Glucokinase by Glucokinase Regulatory Protein	Reactome Pathways 2024	1.0	null
BRD-K99404845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12137
BRD-K35788497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37721
BRD-K71919612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.02636
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Nuclear Pore Complex (NPC) Disassembly	Reactome Pathways 2024	1.0	null
VENTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00677
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2299
PABPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15673
HC-01-FD24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260909
CRCGN017_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.82028
GSE76771_1_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.166
PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
MYC-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE99875_2_v_0_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24266
K562_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164713
intracellular protein transport	GO Biological Process Annotations 2023	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.7052
BRD-K30761927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68044
GSE190316,GSE190324_0_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5548_NDUFAF5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.571342
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.68
Nucleomorph	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.97
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31059159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1653
Gene expression (Transcription)	Reactome Pathways 2024	1.0	null
GSE131377_1_v_3_spocd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EFM19_BREAST	CCLE Cell Line Proteomics	1.0	4.48249
Nuclear inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.086
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:E07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01171
GSE92364_0_v_3_asparaginase_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE248858_1_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210476_2_v_6_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.62223
JB-89-SI60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237241
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2857
BRD-K57026098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13567
GSE172247,GSE172250_0_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
NoRC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.763
LGALS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.47207
S0-EE-WH3B_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215368
HC-11-RK51_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204572
BRD-K72800151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14285
BRD-K18462967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36177
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.819
GSE131565_1_v_0_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A84816049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05678
BRD-K86288396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41372
BRD-K03308716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50436
BRD-K73739802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10119
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.34
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208226
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05303
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_2_TurboID_10m_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FED48h_vs_D2FAST48h_968_AR-DE-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05777604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28043
ARHGEF12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38866
BRD-K73579545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48442
BRD-A78125048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04731
BRD-K91459693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27898
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Olfactory tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.787
BRD-A39506880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72734
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.790497
GSE200897_1_v_0_pold1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE252857_1_v_0_klf15_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1563	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.87824
BRD-K90787403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08458
chr7_23173315_G_T_b38	GTEx eQTL 2025	1.0	1.06907
Cell Cycle, Mitotic	Reactome Pathways 2024	1.0	null
GSE129370_0_v_1_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K91818277	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2207
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.189
HOXB9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4514
ENTPD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06714
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
chr7_23193040_T_C_b38	GTEx eQTL 2025	1.0	1.1583
CD-16-KY17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249071
K562_INO-1001_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173832
JC-06-ED36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292969
EE-98-PF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.883849
BRD-K33640715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11059
BRD-K79734831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16674
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K69491845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93347
GSE224969,GSE224971_3_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
XC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.157
EVI1-22308434-SKOV3-HUMAN-OVARY-OVARIANCANCER	ChEA Transcription Factor Targets 2022	1.0	null
GSE133683_3_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BT12	DepMap CRISPR Gene Dependency	1.0	2.40614
BRD-K42126155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25159
GSE210377_0_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K78643409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27554
CRCGN016_MCF10A.TP53.M_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3575
BRD-K96431636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58821
NR4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06129
GSE184892_4_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Iniparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0226007
Respiratory mucus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
GSE163282_12_v_8_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197555_0_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10123
GSE175787_4_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	1.0	null
Crown gall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
CRCGN016_MCF10A.WT.HP_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26504
CAKI1	DepMap CRISPR Gene Dependency	1.0	2.13085
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.7643
BRD-A63503250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17426
BRD-K52436508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18311
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.42222
BRD-K87995704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89461
BRD-K30214140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21363
CLN6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78225
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.819
BRD-K74879991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40996
BRD-K64665523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31105
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4473
GSE209601_0_v_1_mef2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
8842_TFCP2L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.520615
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3219
IGFLR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32454
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38819
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06129
Deafness	DisGeNET Gene-Disease Associations	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246105
K562_Mercaptopurine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162265
HOXD10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1859
PMC11282827-40659_2024_524_MOESM5_ESM.xlsx-TAL1-sequence_name_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
Brain endothelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.903
BRD-K52124788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01464
GSE145639_1_v_2_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K31805261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05552
BRD-K30674442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50778
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.142
Lung carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.819
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.91645
BRD-A20242387	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58107
Transport of the SLBP independent Mature mRNA	Reactome Pathways 2024	1.0	null
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
GSE214931_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149684
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200696
thiamphenicol-glycinate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86261
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K35119180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.66147
OC-71-BZ81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.220046
TFAP2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03563
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K84636055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34112
PMC3435504-msb201237-s2.xls-Supp_Table_4b-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
496100605_TCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.03988
BRD-K35123860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07957
Apoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.4
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.89632
H1-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01567
BRD-K75100119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30542
BRD-K83487481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63884
Endodermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.94
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5519
CRCGN017_MCF10A.WT.HP_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1091
GSE111247_11_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TF1	DepMap CRISPR Gene Dependency	1.0	2.01377
BRD-K35726223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37944
Glucose metabolism	Reactome Pathways 2024	1.0	null
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Macronucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.529
KDM4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01946
PMC2263127-pone.0001816.s001.xls-E2F3_down_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_HEPG2_48H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09834
GSE174498,GSE174500_0_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CD-59-PT17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.437667
A549_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144702
Nuclear pore linkers	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.305
BRD-K26836050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84351
TYW3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10339
PMC8283158-mmc2.xlsx-TCF4_ChIP-symbol_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
Multiple synapse bouton, contacting multiple dendrites	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.296
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-MITF_Targets_enrichment-Unnamed_32_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83919473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17322
Post-translational protein modification	Reactome Pathways 2024	1.0	null
BRD-K17078647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85921
SARS-CoV-2-host interactions	Reactome Pathways 2024	1.0	null
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199899_4_v_2_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PSMB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64648
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.756223
496100420_PCx_probable Alzheimer's disease_no TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.96841
A549_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163275
BRD-A13983189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99586
GSE193993_4_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Transport of Mature mRNAs Derived from Intronless Transcripts	Reactome Pathways 2024	1.0	null
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Germ tube	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.851
BRD-K50498614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03634
GSE233647_4_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K25878187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08068
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.67113
Granular component	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.698
BRD-K63859730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34485
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HSCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18912
BRD-K01166365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02706
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K53771043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76142
BRD-K46739745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31671
BRD-K74663731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49778
K562_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155409
BRD-K22139757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13819
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K20288742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39963
CRCGN017_MCF10A.TP53.M_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08821
BRD-K78642007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70928
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9634663-DataSheet10.xlsx-K562-MYC-AID_RNA-Seq_1326_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K37719063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01276
BRD-K87884409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05263
HARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00094
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D3_1784_AR-DEGS-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K70566686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16664
CRCGN011_HEPG2_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1972
CLIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01166
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
IC-80-CT90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255426
nucleocytoplasmic transport	GO Biological Process Annotations 2025	1.0	null
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K66494817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80461
KNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.822
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228109
GSE214248_0_v_1_cxcl8_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.78407
BRD-K09721398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29552
BRD-K15833017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24416
BRD-K07794261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1342
GSE93309_5_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169205_0_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
D283MED	DepMap CRISPR Gene Dependency	1.0	6.52593
ipi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
Nuclear envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
A549_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0176848
MFE296	DepMap CRISPR Gene Dependency	1.0	2.76185
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.473239
GSE57397,GSE57399_1_v_0_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
Set3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.867
Fibrillar center	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.799
ELAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10955
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.4084
CRCGN014_HEPG2_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.20034
TO14	DepMap CRISPR Gene Dependency	1.0	2.06147
diclazuril	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33114
BRD-K13309514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60219
HPB-ALL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.664
BRD-K85622666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62933
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K57359365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00053
496100405_TCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.17467
BRD-K47417426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25582
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K93561942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18657
Bloodstream form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.961
DD-43-WW40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210483
A549_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0175958
CRCGN017_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54915
BRD-K90205159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98999
AB-12-PP61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221559
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K41185648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.048
nucleus	GO Cellular Component Annotations 2025	1.0	null
BRD-K44944875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12728
BRD-K62718031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17149
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8964
BRD-K35383890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48347
Nuclear RNA export factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.276
GSE244710_1_v_0_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100519_HIP_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.51824
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K89362730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40086
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.383843
Lung bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.77
CRCGN013_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07495
K562_Veliparib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0208725
Processing of Capped Intron-Containing Pre-mRNA	Reactome Pathways 2024	1.0	null
CAL51	DepMap CRISPR Gene Dependency	1.0	2.92528
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	Reactome Pathways 2024	1.0	null
Brain microvascular endothelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.935
BRD-K14399036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00686
NELFCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15425
Spinal muscular atrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.481
HSQ89	DepMap CRISPR Gene Dependency	1.0	4.61667
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246927
PMC3435504-msb201237-s2.xls-Supp_Table_4a-MYBL2_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
BRD-K11247495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1672
BRD-K05802716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67967
BRD-K00377328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17827
GSE147056_4_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleocytoplasmic transport	GO Biological Process Annotations 2023	1.0	null
Metabolism of non-coding RNA	Reactome Pathways 2024	1.0	null
Interactions of Vpr with host cellular proteins	Reactome Pathways 2024	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98175
Nuclear pore central transport channel	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.771
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Type II spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K19501975	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24787
CRCGN016_MCF10A.WT.HP_24H:B13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10947
FKBP1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77116
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.48961
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.819
BRD-K38633800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13657
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.377761
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
GSE137144_2_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3573
exon-exon junction complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.134
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70835
BRD-K60053695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00585
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.89299
Parkinson's disease	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.73979
PMC11686977-12967_2024_5960_MOESM9_ESM.xlsx-Sheet1-Supplementary_Table_4_The_co-precipitated_proteins_of_the_four_RORA_promoter_probes_P1_P2_P3_and_P4_and_beads_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13486159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32552
SW1088	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.17324
ZIK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27738
nuclear export	GO Biological Process Annotations 2025	1.0	null
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
CRCGN012_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88954
1941_CTPS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.545314
BRD-K39087188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01142
BRD-K14987634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09497
ZNF853	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4951
BRD-A14098586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17721
SLC transporter disorders	Reactome Pathways 2024	1.0	null
GSE201882,GSE201883_3_v_5_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K58028568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13044
BRD-K17536501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49421
PMC7457511__F9	PFOCR Pathway Figure Associations 2023	1.0	null
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-605-ENSG00000106511_MEOX2	Rummagene Transcription Factor Associations 2026	1.0	null
chr7_23202247_C_T_b38	GTEx eQTL 2025	1.0	2.45138
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9417
VERO-76 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.828
K562_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164113
BRD-K26479796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43039
GSE249544,GSE249637_9_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
7608_RUVBL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.677103
CB-15-RU50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201494
CRCGN017_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28492
Cell trailing edge	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.52
CRCGN008_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.603
Nucleolus organizer region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.744
GSE201309_4_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K23366960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96956
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.58396
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224688
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K28700379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.65956
ERVV-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59751
BRD-K93697231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13867
BRD-K29392777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5122
GSE197562_2_v_3_nox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K69580972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67981
BRD-K65438558	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54549
GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
M Phase	Reactome Pathways 2024	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
Transport of the SLBP Dependant Mature mRNA	Reactome Pathways 2024	1.0	null
GSE229973_3_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154253_1_v_0_tnfaip8_human	RummaGEO Gene Perturbation Signatures	1.0	null
XF-76-GE52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304829
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE136622_7_v_3_srpk3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81082554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52119
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3242
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K24815102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00761
BRD-K81568980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28553
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75148
CRCGN008_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25985
Diarrhea	DisGeNET Gene-Phenotype Associations	1.0	null
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.702718
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K33044659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00407
CRCGN014_HEPG2_3H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03303
MB-32-LQ97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218238
Nuclear pore	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.21725
BRD-K92457070	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19463
GSE233647_4_v_5_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-ATF3_TGACGTCA_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K04108962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06641
RNA binding	GO Molecular Function Annotations 2023	1.0	null
BRD-K03015524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03261
BRD-K45522895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65313
BRD-K88421348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12112
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXC9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0553
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	110.157
Anterior olfactory nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.748
A549_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160115
BRD-K61934967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8628
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-ATF3_TGAYRTCA_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
K562_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172902
Transport of Mature mRNA derived from an Intron-Containing Transcript	Reactome Pathways 2024	1.0	null
BRD-K48338059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0578
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.142
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0467
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.819
BRD-K50665432	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34396
WASHC2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13652
HC-76-SY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289148
SDF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58457
KMS20	DepMap CRISPR Gene Dependency	1.0	2.56737
BRD-K57472585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19314
BRD-K30589514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10404
SUMOylation of ubiquitinylation proteins	Reactome Pathways 2024	1.0	null
CRCGN010_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70231
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K65891102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.78629
TA-20-FO62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290996
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8961
SKBR3	DepMap CRISPR Gene Dependency	1.0	3.13616
BRD-K61020385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40398
Infectious disease	Reactome Pathways 2024	1.0	null
BRD-K10027041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91987
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.32629
Chronic Obstructive Airway Disease	DisGeNET Gene-Disease Associations	1.0	null
NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.11385
GSE223893_1_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZSCAN20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34724
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prader Willi and Angelman syndrome	WikiPathways Pathways 2024	1.0	null
Transcription factor TFIIK complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.14
GSE164529_0_v_1_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
MC-40-IP75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.472482
9962_ZBED2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.52337
GSE217405_0_v_1_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148815
IGR37_SKIN	CCLE Cell Line Proteomics	1.0	2.18536
CRCGN012_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28729
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
SMIM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03508
FD-74-LD52_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.2727
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.4176
K562_GSK-LSD1 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014699
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.819
BRD-K03606830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31462
GSE224294_4_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SW982	DepMap CRISPR Gene Dependency	1.0	2.30176
YA-34-DT48_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211845
KLHL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45439
BRD-K66852478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78568
BRDT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17719
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11687039	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45126
BRD-K74968522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91016
CD-16-KY17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.485753
BRD-K31748787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22196
GSE210373_0_v_1_cntnap4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NEP/NS2 Interacts with the Cellular Export Machinery	Reactome Pathways 2024	1.0	null
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	161.605
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.78301
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lewy body-like hyaline inclusion	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.707
BRD-K46924722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42993
Cellular responses to stimuli	Reactome Pathways 2024	1.0	null
BRD-K24499562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.83676
BRD-K79709959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68311
JHUEM1	DepMap CRISPR Gene Dependency	1.0	4.34738
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68855
CCT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91454
TASK1	DepMap CRISPR Gene Dependency	1.0	2.26898
BRD-K28414977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69688
BRD-A51381734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16937
BRD-K21838437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38877
UPCISCC026	DepMap CRISPR Gene Dependency	1.0	2.09864
BRD-K20918933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22368
Type I pilus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.682
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.7227
42MGBA	DepMap CRISPR Gene Dependency	1.0	2.21534
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.664876
Spindle pole body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.864
BRD-K22384464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05016
Nuclear lamina	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.194
Nuclear membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.136
SNU182	DepMap CRISPR Gene Dependency	1.0	3.27751
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
SYCP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09125
BRD-A15798299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40442
K562_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163447
BRD-K14813771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49755
snRNP Assembly	Reactome Pathways 2024	1.0	null
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.355
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20856
SUMOylation of DNA damage response and repair proteins	Reactome Pathways 2024	1.0	null
BRD-K25942808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42475
GSE159678_4_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D3_2440_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.35286
UNC13D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6778
Hairy root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
BRD-K39179354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41543
BRD-K62236460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07032
SUMOylation of SUMOylation proteins	Reactome Pathways 2024	1.0	null
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
chr7_23151875_TA_T_b38	GTEx eQTL 2025	1.0	1.72786
BRD-K43922968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31091
BRD-K45520793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14102
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF283	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22251
L3HYPDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31547
BRD-A78982410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09034
BRD-K26195700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06187
BRD-K08476323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09496
BRD-K61168922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70494
PMC7335061-41467_2020_17150_MOESM4_ESM.xlsx-Table_S3-KLF4_correlates_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203308_9_v_10_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
1812_COX19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.663032
BRD-K12260863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65009
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE183335,GSE183351_3_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222983
NANS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3687
Aleutian mink disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
GSE152734,GSE152735_1_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7785
PMC12585103-pbio.3003444.s013.xlsx-List_of_genes_for_GO_analysis-List_of_genes_undergoing_significant_MXE_upon_PRMT5_KD_under_hypoxia_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K06226868	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3932
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
PTGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53292
JUND-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K12555854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7946
CRCGN012_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.05493
BRD-K27881453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06369
Export of Viral Ribonucleoproteins from Nucleus	Reactome Pathways 2024	1.0	null
GSE220520_1_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150549
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.69065
NP2	DepMap CRISPR Gene Dependency	1.0	2.36545
Foxo3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.3229
ZNF532	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03232
BARHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9106
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mushroom body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.816
BRD-K89376872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7893
BRD-K26393435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29572
iron-sulfur cluster assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.77
BRD-K36120694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26534
BRD-A09115727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83228
BRD-K29636267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13641
GSE220520_6_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11908325-media-2.xlsx-Table10_MR-Unnamed_7_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
1441_CDK7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.37102
RBMS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55807
HOXC12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6538
BRD-K25658788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08832
BRD-K93210276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42151
D458	DepMap CRISPR Gene Dependency	1.0	3.52526
BRD-K21996934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.78137
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K94049419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13516
CRCGN015_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25046
Influenza Infection	Reactome Pathways 2024	1.0	null
K562_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135136
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K26018295	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75462
GSE217405_3_v_2_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K34929471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54211
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16965
chr7_23192363_G_T_b38	GTEx eQTL 2025	1.0	1.00704
BRD-K77609086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01916
tRNA processing in the nucleus	Reactome Pathways 2024	1.0	null
BRD-K61386375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28598
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Striatonigral neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.755
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K93040255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70707
BRD-K74755318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59837
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.57331
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Nuclear periphery	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.598
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6836
COX7A2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07974
S462	DepMap CRISPR Gene Dependency	1.0	4.0452
JHOS4	DepMap CRISPR Gene Dependency	1.0	4.46119
K562_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159201
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE133213_9_v_15_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Down_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K76197651	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42104
GSE162892_3_v_1_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAGOH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79605
CRCGN017_MCF10A.WT.HP_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34303
PPIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20358
BRD-K47599758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35304
BRD-K61973443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13327
7499_RPS11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09306
BRD-K84761515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16987
GSE154337_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K56041932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11931
GSE95077_5_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_3_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1048	DepMap CRISPR Gene Dependency	1.0	2.5395
BRD-K64939364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21604
CRCGN015_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7076
BRD-K51535480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32329
BRD-K45986774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18877
GSE231799_2_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K68160857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10161
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nuclear pore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.462
BRD-K98153780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13057
DA-10-ZX00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207223
GSE175787_13_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.886733
K562_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228744
BRD-K10416099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1934
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4096
BRD-K67535324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0111
BA-56-QV45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211229
OE-31-YC41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328071
K562_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136937
CTNNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11046
A549_Ruxolitinib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126858
BRD-K02529187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0852
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HCMV Late Events	Reactome Pathways 2024	1.0	null
K562_Triamcinolone Acetonide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164305
BRD-K27320944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9004
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
KP2_PANCREAS	CCLE Cell Line Proteomics	1.0	5.82567
K562_Cimetidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0312461
Collagen beaded filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.618
Leaf vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.14
HIV Life Cycle	Reactome Pathways 2024	1.0	null
ZNF236	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29257
BC-40-TU13_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244027
Primary hyperoxaluria type 2	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
GE-34-TW62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275976
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05432466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09242
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
BRD-K23435841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97778
ND-36-VC68_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200042
GSE100102_0_v_6_cgas_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177232
SF3B6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21943
CRCGN014_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03385
BRD-K79954583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07855
BRD-K90047132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48343
FA-92-JL46_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.271413
CNN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27872
BRD-K01639528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44085
BRD-K97393725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05121
CRCGN016_MCF10A.TP53.M_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4185
Rind	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE139239_2_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K52532740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97611
AD-51-FB60_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.478129
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.146
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5517
HCC-15	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
Endonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.849
BRD-K16525290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24262
NCIH1048_LUNG	CCLE Cell Line Proteomics	1.0	4.21326
BICR6_UPPER_AERODIGESTIVE_TRACT	CCLE Cell Line Proteomics	1.0	2.19434
GSE195663_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32954
Cytoplasmic side of nuclear pore	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.939
BRD-K91277001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30092
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7469
BRD-K70357895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19302
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9268
K562_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146999
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9492
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.142
PRKCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03083
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Host Interactions of HIV factors	Reactome Pathways 2024	1.0	null
PEO1	DepMap CRISPR Gene Dependency	1.0	2.87558
KDR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75817
PPWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2833
4908_MCOLN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.72165
K562_S3I-201_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014623
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
5054_MICAL3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.615483
BRD-K65729622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57685
GSE201735_3_v_1_cdca7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21955645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5709
LPXN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45102
Chaperone-mediated protein folding complex	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
FTO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28991
SNUC1	DepMap CRISPR Gene Dependency	1.0	2.57995
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263873
GSE148321,GSE169423_0_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8552907__F4	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K34931072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42908
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5353
BRD-K54507743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47868
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nuclear membrane	GO Cellular Component Annotations 2025	1.0	null
Procyclic form	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.027
Organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K48372955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19232
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.658011
K562_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0149025
BRD-K89476396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21834
BRD-K19315592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01239
BRD-K61144709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40975
CRCGN017_MCF10A.WT.HP_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4242
BRD-K91671568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.596
BRD-K29371459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05819
ASNSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55223
Endocytic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.589
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61392
MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	3.21367
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38185
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.07575
CYB561D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14326
Cellular responses to stress	Reactome Pathways 2024	1.0	null
GSE164483_2_v_0_venetoclax_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K34024207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05115
AF-00-QK19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299358
BRD-K63998843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33033
GSE169205_0_v_2_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TR146	DepMap CRISPR Gene Dependency	1.0	6.59222
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.24815
GSE207135_2_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PPRC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26693
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
KYAE1	DepMap CRISPR Gene Dependency	1.0	2.56178
BRD-K80298486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74429
Fetal akinesia deformation sequence syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
496100418_TCx_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.07669
Metabolism of proteins	Reactome Pathways 2024	1.0	null
chr7_23205950_A_G_b38	GTEx eQTL 2025	1.0	1.53837
BRD-K83238251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6694
BRD-K20600965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20107
LE-65-RW44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230656
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.74795
BRD-K87080232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47535
TUBGCP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39693
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8674
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3857
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0087
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.00702
SEC61B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14927
BRD-A81407814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11915
DD-74-PJ26_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.302219
BRD-K74834319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40925
TAGLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26823
Nuclear envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.251
K562_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149141
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23158
GSE210476_2_v_1_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE108614,GSE108615_3_v_2_setd1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.295821
BB65-RCC	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.15256
BRD-K68595406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05828
PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-14-NRF1_NRF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE180377_2_v_1_lipa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94795
Developmental dysplasia of the hip 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
BRD-K12955049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53
BRD-K62358193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92844
DPPA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32555
Achalasia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
BRD-K65368100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44706
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6936
2313287	DepMap CRISPR Gene Dependency	1.0	2.07964
K562_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133707
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K13534347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98267
cyclothiazide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52612
K562_Sodium Phenylbutyrate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176917
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
plant-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.235
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.013
BRD-K64663625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24984
BRD-K35943892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51023
FA-92-JL46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355627
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22034
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_14_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE248858_4_v_0_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:F13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.77119
BRD-K36198653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52256
ZNF708	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16741
DLST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03412
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47885
TTI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23491
GSE87615_2_v_3_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K01467488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79416
A549_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207947
SARS-CoV-2 activates/modulates innate and adaptive immune responses	Reactome Pathways 2024	1.0	null
LJI308_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00528562
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151226
CENPQ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7303
TEKTIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19836
BRD-K26194226	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21408
Nuclear import of Rev protein	Reactome Pathways 2024	1.0	null
Metabolism of carbohydrates	Reactome Pathways 2024	1.0	null
AD-51-FB60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254856
Lethal congenital contracture syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.791
GSE133213_9_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Messenger ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.846
BRD-K44576681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50612
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K24343201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0101
nuclear transport	GO Biological Process Annotations 2025	1.0	null
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.411963
ANPR-A receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.899
KP1N	DepMap CRISPR Gene Dependency	1.0	4.03816
TNPO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04529
PMC11437185-41467_2024_50986_MOESM4_ESM.xlsx-MECOM-IP-MS-Gene_names_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Viral Infection Pathways	Reactome Pathways 2024	1.0	null
UMUC3	DepMap CRISPR Gene Dependency	1.0	4.14097
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05335635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94217
BRD-K89338336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65277
BRD-K33456231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0032
mc116	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.831
BRD-K08009212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1154
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2768
PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-156-MEOX2_MEOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Regulation of HSF1-mediated heat shock response	Reactome Pathways 2024	1.0	null
BRD-K34369474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60607
CRCGN016_MCF10A.WT.HP_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02804
GSE141453,GSE141454_0_v_4_card11_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K36852613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68826
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lethal congenital contracture syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.583
mRNA cap methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.5
GSE127790_5_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute endophthalmitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.278
BRD-K03287885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1701
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.363
GSE202744_1_v_3_toyocamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K47471281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04136
CEP250	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27413
CRCGN008_HEPG2_24H:B14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4267
CA-73-BW50_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27508
KLK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06922
GSE139239_3_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SUMO E3 ligases SUMOylate target proteins	Reactome Pathways 2024	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37524
K562_Clevudine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168163
NF-kappaB p50/p65 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.799
ARFGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1525
9910_XRN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533039
BRD-K76833108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18123
BRD-K20847739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97721
BRD-K44897610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01914
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
GSE252857_1_v_0_prednisone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
BRD-K02920459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64164
K562_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155195
BRD-K81001899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00426
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K04378630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12623
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
Barr body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.859
CRCGN010_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.25564
ALDH1B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44594
HEYA8	DepMap CRISPR Gene Dependency	1.0	2.00395
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	112.009
BRD-K01283689	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03285
496100396_HIP_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.64398
BRD-K29661539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40023
BRD-K65440031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01546
PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-GSE131737_TFAP2B_target_genes_G_gallus_1347_TFAP2B	Rummagene Transcription Factor Associations 2026	1.0	null
SET2	DepMap CRISPR Gene Dependency	1.0	2.02709
BRD-K28008176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36334
BRD-K54079231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28739
GSE261177_0_v_1_tnfrsf12a_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K47217000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34442
BRD-K40917447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31074
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.841736
TD-69-UA90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208684
BRD-K49903196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23407
PMC7338542-41389_2020_247_MOESM5_ESM.xlsx-BRN2_2_of_3_UP_48_h-Symbol_POU3F2	Rummagene Transcription Factor Associations 2026	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.33146
BRD-K34228325	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01154
GSE216540_0_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular protein transport	GO Biological Process Annotations 2025	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13785
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.606
PMC6961462-NIHMS1544104-supplement-Sup_Tab.xlsx-Sup_Table_3_a-Supplementary_Table_3_Genes_Regulated_by_A_MYB_in_Humans_and_Macaques_Bold_genes_with_reduced_expression_in_Group_3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346608
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GAMG	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.38656
BRD-K68676343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04832
BRD-A69110668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3132
CAKI1_KIDNEY	CCLE Cell Line Proteomics	1.0	2.43919
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.389042
Bladder	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K59518944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28347
Antiviral mechanism by IFN-stimulated genes	Reactome Pathways 2024	1.0	null
TK	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.75201
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
CRCGN010_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03635
BRD-K57027644	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23119
GSE217405_0_v_1_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.506
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E18-D1_1591_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE91015_0_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.7814
Disorders of transmembrane transporters	Reactome Pathways 2024	1.0	null
BRD-K06994380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1518
Regulation of Gene Expression and Nuclear Transport	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
STYXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02787
BRD-K70584304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26528
X-linked dystonia-parkinsonism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
496100538_HIP_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12233
LACTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03634
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE76771_2_v_3_atf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.79695
GLB1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02133
GSE229344_2_v_0_cyb5r3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56276074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50277
Rhox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.6326
BRD-K15433418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77404
HT29_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	4.50363
K562_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0226713
FOSL1::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5171
GSE160001,GSE160670_3_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUMOylation of RNA binding proteins	Reactome Pathways 2024	1.0	null
GSE174498,GSE174500_5_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08145
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RARG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05357
TE-26-XS06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320142
CRCGN016_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2872
BTBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80519
Nucleolar chromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.601
BRD-K78755361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17208
496100592_FWM_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.45396
CRCGN013_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2786
PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
496100516_FWM_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.3042
BRD-K89040444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13383
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
triple-A syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.851
Uropod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.538
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.17218
KIFC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01919
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.86652
BRD-A20256229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21487
PMC10279693-41389_2023_477_MOESM2_ESM.xlsx-N_MYC-WDR5-DMSO-overlap_peaks_a-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
HSC39	DepMap CRISPR Gene Dependency	1.0	2.27643
BRD-K10987837	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.41291
HSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08724
GSE129389_0_v_5_tropifexor_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.71
ARHGAP11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37128
Lung cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.819
AC-71-YF45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483084
GSE154577_2_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.57525
PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_GATA3-GeneSymbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72135113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00971
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.354178
Transport of Mature Transcript to Cytoplasm	Reactome Pathways 2024	1.0	null
GSE163920_1_v_0_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49455
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31870622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90527
BRD-K13707774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0035
GSE134316_1_v_0_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K62152527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09006
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29815
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.57197
NUP58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09346
GSE240439_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K08438266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36538
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30961
BRD-K79303560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8903
JHH6_LIVER	CCLE Cell Line Proteomics	1.0	3.11312
K562_Navitoclax_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139086
OB-20-LP90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258637
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7829
BRD-K71345532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73828
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE57875_1_v_0_hnrnpl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3355086-pgen.1002728.s003.xlsx-Tabelle1-HEY2_upregulated_HEY2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69624346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14096
PATU8988T_PANCREAS	CCLE Cell Line Proteomics	1.0	4.17093
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162703
GD-59-OG21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201069
rifamycin-sv	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02451
GSE248858_4_v_3_tcpobop_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265361
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SLC4A1AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99603
PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11	Rummagene Transcription Factor Associations 2026	1.0	null
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	88.5839
THO complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.568
Extrachromosomal circular DNA	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.544
BRD-K23292451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98192
SHLD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03272
ISG15 antiviral mechanism	Reactome Pathways 2024	1.0	null
BRD-K59149254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74201
BRD-K09511124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2432
BRD-K94521090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12046
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K72588970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39808
GSE139120_1_v_0_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Transcription export complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.614
CRCGN015_MCF10A_48H:D02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18686
Chronic Kidney Disease	DisGeNET Gene-Disease Associations	1.0	null
BRD-K73706189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07833
BRD-K62612761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4572
PMC5404927-elife-24463-supp1.xlsx-1b_ERM_proteome-Gene_names_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61733751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73534
BRD-K73608149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08238
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2558
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PTP4A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00962
CNPPD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29349
BRD-K43108627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23831
LCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14042
CD-13-QZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210446
Viral Messenger RNA Synthesis	Reactome Pathways 2024	1.0	null
K562_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014129
ACBD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00759
Mitotic Prophase	Reactome Pathways 2024	1.0	null
TC-95-IR96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386489
tRNA processing	Reactome Pathways 2024	1.0	null
GSE197564,GSE198513_2_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K08431704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12205
MJ	DepMap CRISPR Gene Dependency	1.0	6.69938
Nuclear Envelope Breakdown	Reactome Pathways 2024	1.0	null
BRD-K73227539	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54525
MERO14	DepMap CRISPR Gene Dependency	1.0	2.98656
K562_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172222
BRD-K07689069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55294
BRD-A00327403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50893
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.389328
BRD-K64509231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2657
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
XE-29-LT20_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22321
GSE166184,GSE166185_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	1.0	null
SBK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01721
CRCGN015_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.0079
CLC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00007
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64567083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60946
SUMOylation	Reactome Pathways 2024	1.0	null
GSE158834_0_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE137144_2_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
AE-00-NY23_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204475
BC-61-BE07_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375869
NS1 Mediated Effects on Host Pathways	Reactome Pathways 2024	1.0	null
BRD-K35480932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20945
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.819
BRD-K90003650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21869
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.553865
ZNF304	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12827
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K19752998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00482
SF3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18802
BRD-K00502656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05565
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH510	DepMap CRISPR Gene Dependency	1.0	4.44334
BRD-K93337444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48041
Disease	Reactome Pathways 2024	1.0	null
Primary hyperoxaluria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.199
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.317232
BRD-K75807957	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52312
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE88819_1_v_2_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
G6PD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48613
BRD-A37056613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31235
BRD-K48459037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38651
BRD-K50710722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00872
PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_3_TurboID_1hr_ERM_proteome-Gene_Name_ETV5	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44177046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33765
GSE135030_8_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.2798
SUMOylation of DNA replication proteins	Reactome Pathways 2024	1.0	null
Leaf sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.688
GSE223893_2_v_10_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AC-47-YZ27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214226
A549_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147951
GSE175787_5_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K76611906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84277
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
C8166	DepMap CRISPR Gene Dependency	1.0	2.80289
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3549
PMC10584948-42003_2023_5398_MOESM4_ESM.xlsx-NUPs_expression-Relative_NUP_expression_with_NUP93_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K66963756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29701
BRD-A34492468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12067
Caudate putamen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.135
INF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27541
EXOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1051
CRCGN017_MCF10A.TP53.M_24H:E05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0856
CE-37-XI06_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213557
OD-96-OP94_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250972
BRD-K35491869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50817
Transport of Mature mRNA Derived from an Intronless Transcript	Reactome Pathways 2024	1.0	null
Lung non-small cell carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.71