association	dataset	threshold value	standardized value
BRD-K44994529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19905
BRD-K07979116	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88823
GSE203060_0_v_1_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TOMM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14056
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.502996
PMC8507136-12935_2021_2224_MOESM5_ESM.xlsx-CREB1_upregulated_RRHO_list-RRHO_concordant_degree_CREB1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_2_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE171712_0_v_1_scgb1a1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3715
GSE145311_0_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K21595913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51321
GSE140200_1_v_3_trim59_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
secalciferol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50728
GSK-1070916	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.09
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NUAK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532598
BRD-K58324650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23544
BRD-K71801719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21769
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.052
ALG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75649
BRD-K93101873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16795
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8229
496100457_TCx_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.28086
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.4022
GSE218356_1_v_0_cited1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K79833963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18928
BRD-A09988375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4886
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3935
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0447
BRD-K38557431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69319
BRD-K09271653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62435
1812_COX19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.880995
KMS26	DepMap CRISPR Gene Dependency	1.0	3.59715
NB13	DepMap CRISPR Gene Dependency	1.0	2.54767
GATA4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6321
MCTP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512114
BRD-K52582315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62737
BRD-K70093308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5193
GSE221327_8_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DGCR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02601
GSE165174,GSE165175_0_v_1_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149264,GSE149267_4_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K88925664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38805
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.566407
pravadoline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29823
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CC2D1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19411
GSE154577_2_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE117042_0_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4226
GSE216043_10_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ARHGAP39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68388
SETX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53163
GSE214823,GSE214824_4_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Parathyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.052
BRD-K10058823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76536
BRD-K74537058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02644
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AZD-5438	DeepCoverMOA Drug Mechanisms of Action	-1.0	-2.47
GSE192689_0_v_2_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Osteophyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.582
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KPNYN	DepMap CRISPR Gene Dependency	1.0	3.90558
GSE86507,GSE86509_0_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SKNMC	DepMap CRISPR Gene Dependency	1.0	2.02082
Pulse pressure	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.05229
BRD-K10781609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97803
RPL23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64262
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NKX6-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.1252
6632_PPIL4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.501313
BRD-K26748243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69104
BRD-K64953645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05172
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.711678
ATXN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01393
PMC4149371-pone.0105180.s010.xls-OCT4-GENE_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE180951_2_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K83229680	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01708
ARGFX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7821
BRD-K99736408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25311
BRD-K33268483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57171
BRD-K86925685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50626
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_1_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
POTEE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16027
BRD-K23327891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03465
BRD-K76482408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.32228
BRD-K97391170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46521
PMC10591418-12711_2023_849_MOESM11_ESM.xls-AA_E10_vs_LS_E10-gene_name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BL70	DepMap CRISPR Gene Dependency	1.0	3.84214
BRD-A39660642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12011
3554_GSPT1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.503799
GSE157555,GSE157556_4_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224004,GSE224005_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178340_7_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153258_1_v_0_dcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
7505_RPS16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.808689
BRD-K52620056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17579
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_5_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0286
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-13q34_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
GSE132948,GSE132949_0_v_3_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HGS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13134
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE107505_1_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92124212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64396
BRD-K98061543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1177
Striate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.709
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
RWDD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27859
GSE202434,GSE202438_9_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K16403365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19226
BRD-K73834056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24547
CAB39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12847
PHOX2B-30127528-KELLY-HUMAN-BRAINNEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
6118_PCED1A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.599847
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.583
4149_INTS4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.569433
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.6464
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
5902_NUP88_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.591784
GSE131649_6_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
yac1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.876
GSE122067_3_v_0_mtch2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K33505770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91513
BRD-K31644794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35806
Fedratinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.51
GSE144115_4_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K78656517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83692
PMC8160578-JCB_202009147_TableS4.xlsx-E2F1_targets-Genes_n_1867_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44328896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59823
BRD-K75842461	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26649
CD151	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12411
BRD-K92158425	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41613
BRD-K22874335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49457
GSE211262,GSE211263_2_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K72646819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38636
BRD-K07839394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03478
FOXD4L3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00647735
Merozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.044
BRD-K02118124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39805
GSE138050,GSE148257_1_v_2_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K29135120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03434
BRD-K03810133	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36546
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
XBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21481
BRD-K94347944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0196
WDR36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01771
SNRPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4136
BRD-K39566424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10144
GSE123943_1_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K56415410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02337
GSE153189_1_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1423
KLE	DepMap CRISPR Gene Dependency	1.0	2.38441
ANKRD35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08656
PMC8481886-Table_2.xlsx-A_subsets-common_MSC_AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WM1799	DepMap CRISPR Gene Dependency	1.0	2.47395
BRD-K05831864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33704
BRD-K93186184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18338
BRD-K99978187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70335
GSE210225_0_v_1_inosine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K17136501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35884
BRD-K25081034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.36099
BRD-K77392050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27213
GSE180277_0_v_1_bach2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE231799_2_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
ubiquitin-protein transferase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K37595074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06606
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE157282_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KARPAS1718	DepMap CRISPR Gene Dependency	1.0	6.86341
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.6586
BRD-K52049165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34169
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272243
GSE193258,GSE193259_5_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EXOC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12998
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K21671578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.078
BRD-K05122615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0658
GSE199541_2_v_4_mbd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE108326_1_v_0_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
LK2_LUNG	CCLE Cell Line Proteomics	1.0	5.65031
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8707
CRCGN015_MCF10A.WT.HP_24H:M23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28276
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
ASF1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83867
PMC11214527-mmc5.xlsx-TP53-gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K64299311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93942
8500_STAT6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.607964
CCT128930	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.98
CMG complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.379
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
GSE157282_0_v_3_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2065
GSE112760,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DMAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14072
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K43282617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45227
SCF-Skp2 ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.465
DNA replication preinitiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.278
CRCGN015_MCF10A_48H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27999
LOXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04146
MCM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.249
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4619
BRD-K08558441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13168
PMC8052288-mmc4.xlsx-PAF-DREAM-Lung_Poor_Survival-Unnamed_2_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K49704392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46455
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
protein ubiquitination	GO Biological Process Annotations 2023	1.0	null
BRD-K48129913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42013
BRD-K55612106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.4991
PPP5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0046188
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.696476
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K07501194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22016
BRD-K25064302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22691
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4077
Head capsule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.571
GATA3-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE255432_7_v_2_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
Atosiban	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
CAKI2	DepMap CRISPR Gene Dependency	1.0	2.68866
Epsilon DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.716
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.232886
PMC8202205-NIHMS1706275-supplement-Table_S3.xlsx-Day_4_GATA6-dependent_genes-GATA6-dependent_mRNA_expression_Day_4_Definitive_Endoderm_FDR_0_05_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE86507,GSE86509_7_v_10_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PIANP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05907
emetine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04027
BRD-K22718400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0749
GSE112760,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brachydactyly type D	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.146
BRD-K10210954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37379
BRD-K83916197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17955
BRD-K43186783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05948
BRD-A13983189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37544
GSE146982_4_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE224311_3_v_0_chaetocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K07300437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09083
PMC12069319-Table1.xlsx-OCAB_p40_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.4498
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GPANK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34049
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
9478_UBA1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.553077
Anterior visceral endoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.934
GSE128076_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12629827-mmc8.xlsx-DDR2_KD-symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NVP-BSK805	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.06
GSE178340_5_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05066
BRD-K10634221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50051
GSE160817_5_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE193258,GSE193259_5_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.361
BRD-K55465787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57267
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:K15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31276
CLDN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25381
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21187
BRD-K84170953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42958
BRD-K95648552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52971
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199541_2_v_5_mbd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE196962_2_v_1_parg_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77743611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34384
BRD-A57353172	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41754
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
BMS-536924	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.06
protein autoubiquitination	GO Biological Process Annotations 2023	1.0	null
GSE115363_2_v_0_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE183413_1_v_2_ash1l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K75584297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7281
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6908
Visceral mass	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.715
HESX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0118
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22717
BRD-K41684304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23519
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.8097
BRD-K63864604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22773
Delta DNA polymerase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.509
PMC9823215-mmc4.xlsx-Sheet1-List_of_genes_commonly_upregulated_by_wild_type_and_zinc_finger_mutant_of_LIN28A_LIN28A	Rummagene Transcription Factor Associations 2026	1.0	null
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.3013
ROS50	DepMap CRISPR Gene Dependency	1.0	2.30997
OSER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1242
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K22870904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17009
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4812
CRCGN017_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07975
regulation of DNA metabolic process	GO Biological Process Annotations 2023	1.0	null
BRD-K68257399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0415
GSE211177,GSE211178_4_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3052
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_ZSCAN4-Unnamed_2_ZSCAN4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94761446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5804
6460_PLRG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.605766
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6311
GSE158456_1_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SLC31A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37957
BRD-K58286708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59987
GSE175787_8_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE203158_5_v_15_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LCAM1	DepMap CRISPR Gene Dependency	1.0	2.00875
CRCGN015_MCF10A.TP53.M_24H:D14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7498
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.419
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3379
BRD-K61934967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21188
BRD-K75807319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76336
BRD-K65564503	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3456
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
Plasmacytoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.074
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17
SMU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5462
CRCGN015_MCF10A.TP53.M_24H:K15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08925
NPPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99801
BRD-K65891102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19497
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6806
GSE153189_2_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MERO82	DepMap CRISPR Gene Dependency	1.0	7.6021
8666_TAF5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.565306
BRD-K76176797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49605
GSE158456_2_v_3_furin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138863_2_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K20847739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02763
2120_DDX41_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.605179
CRTC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53637
CRCGN017_MCF10A.WT.HP_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0949
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.290617
GSE157555,GSE157556_4_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:F08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0175
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7382
GSE157555,GSE157556_0_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135244_0_v_1_trdmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ES5	DepMap CRISPR Gene Dependency	1.0	3.27774
BRD-K07020302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40197
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.842572
NSG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34581
GSE157911_1_v_0_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4149371-pone.0105180.s010.xls-NANOG-GENE_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5193459-pone.0168968.s009.xlsx-Dharmacon_OTP_siRNA_Area-Symbol_OTP	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_ZR75_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ONCODG1	DepMap CRISPR Gene Dependency	1.0	2.81772
Mitochondrial outer membrane translocase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.001
BRD-K42663371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68636
BRD-K98944347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24466
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_ZSCAN4-Unnamed_1_ZSCAN4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K11003742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14927
GSE151782_4_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K75657700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02526
BRD-K77718491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40976
CRCGN015_HEPG2_48H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.91561
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5198
BACH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5143
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.052
PMC12315868-Supplemental_Data_S1.xlsx-Supplemental_Data_S1F-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05181466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24704
GSE154577_13_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186483_1_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HMBOX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4895
BRD-K38347298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3301
PMC10866659-jci-134-176311-s178.xlsx-S3_TurboID_vs_RUNX1-RUNX1T1-gene_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07396550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54196
GSE218060_2_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216043_11_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K62650632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29276
RCM1	DepMap CRISPR Gene Dependency	1.0	4.55585
GSE147626_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8185471-mmc4.xlsx-D2-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_2_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74933734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36083
BRD-K30284601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50124
FUT8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00502725
TRPS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8514
Intermediate filament cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
Parahippocampal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.555
GSE86507,GSE86509_0_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K55164454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67994
regulation of DNA replication	GO Biological Process Annotations 2025	1.0	null
Azilsartan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pharyngeal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.185
496100335_PCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02191
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.534903
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K90325960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11573
MCM10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12279
ZKSCAN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.892
BATF::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5377
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39672303	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67618
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.7456
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5664
CRCGN015_HEPG2_48H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00487
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.4906
ER to Golgi transport vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.682
MS4A6E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00619044
BE(2)-M17 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.259
Cytoskeleton	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.532
7381_OBI1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.646921
BRD-K75887263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78032
T-cell chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239373_0_v_1_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.082
6024_PABPC1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.660343
CRCGN015_MCF10A_48H:J16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.27
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3733
VASN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14888
Large artery stroke	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.530103
BRD-K39326623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7861
Birth weight	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.869897
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
6715_PRAME_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.584274
GSE224131_3_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Osteoclast stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.406
OGFRL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51822
BRD-K18262761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17757
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-OLIG2_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_0_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE225083_0_v_1_kras_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IRF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.9167
PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE159049_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K86750448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46329
BATF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4384
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_HEPG2_48H:M24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29251
BRD-K25426017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16172
BRD-K14392619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01329
BRD-K99939253	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95823
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K86086888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21888
VAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25601
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	110.803
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.12141
PMC9376070-41419_2022_5157_MOESM18_ESM.xlsx-Sheet1-Table_S4_Differentially_expressed_genes_of_HNRNPC-KD_and_NC_cells_identified_in_the_RNA-seq_analysis_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201217_2_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K48294384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32353
BRD-K62800316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4722
BRD-K06218527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16838
GSE216043_7_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0156644
CENPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04327
BRD-K04196669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34131
BRD-K32235162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11671
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE178340_1_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE153871_1_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10787250-BLOODA_ADV-2022-008899-mmc1.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_commonly_up-_or_downregulated_in_CBFA2T3_GLIS2_leukemia_GLIS2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135400_2_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195663_7_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1451
BRD-K72687327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48047
SLC24A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17255
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2681
BRD-K71775851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3636
GSE133213_6_v_3_znrf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
ISL1-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K48389907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37086
GSE135350_3_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_down_VENN-1175_elements_included_exclusively_in_HIF1_down_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K02809100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11196
NCIH1573	DepMap CRISPR Gene Dependency	1.0	4.47536
GSE122378_0_v_1_carmil3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ACAD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47059
c-Fms-IN-3	DeepCoverMOA Drug Mechanisms of Action	1.0	0.35
Posterior pharynx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
BRD-K15008902	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60748
Pelvis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.169
BRD-K87146261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25658
BRD-K09071517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45466
WSUNHL	DepMap CRISPR Gene Dependency	1.0	3.24967
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYCN-28898695-NB1643-HUMAN-NERVE-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
ubiquitin-like protein transferase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K60716223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01701
BRD-K49528360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63406
GSE193334_1_v_0_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXC10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.902
Ribulose bisphosphate carboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.985
FCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03469
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1341
CRCGN017_MCF10A.WT.HP_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3479
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.627753
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K01083922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08264
BRD-K04695511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06737
BRD-K21584435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23112
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PEX12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0097
GSE102269_1_v_2_clpp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE202284,GSE202289_1_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OE33_OESOPHAGUS	CCLE Cell Line Proteomics	1.0	2.57867
BRD-K31883758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21835
GSE179880_10_v_3_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K74015591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34227
OCIMY7	DepMap CRISPR Gene Dependency	1.0	7.85136
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.052
NLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11339
GSE111881_0_v_1_znf768_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K16604405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95649
RELA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14445
PMC6811834-sby183_suppl_supplementary_data_set_1.xls-ZNF804A_DEX_FDR_0_01-Gene_Symbol_ZNF804A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14258088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02293
GSE151782_6_v_5_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Attention deficit hyperactivity disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6452
LHX9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0599
NOG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23092
PARP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93409
CBLC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01932
RAB15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10651
CRCGN016_MCF10A.WT.HP_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01542
CRNKL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0485
496100430_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.12143
BRD-K71243741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58902
GSE114992,GSE114993_1_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K33122655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19023
BRD-K14907323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45472
GSE130081,GSE130082_0_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_0_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.05
GSE184892_7_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GEN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03278
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K54100265	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42844
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0339
BRD-K73376409	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61037
PMC11242342-jcav15p4513s1.pdf-32-ZNF75A_ZNF75A	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221363
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9643
BRD-K74512976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74915
BRD-A27407220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14761
CRCGN015_MCF10A_48H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	7.6354
GSE226249_5_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE68155_1_v_0_gpr3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20769
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_46_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
C-33A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
SNUC1	DepMap CRISPR Gene Dependency	1.0	3.01878
BRD-K39491844	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01552
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2985
DDX24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.06194
GSE211177,GSE211178_9_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_OCT4_targets_Boyer_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE122215,GSE122217_0_v_2_peg10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K95573463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24981
PMC8481886-Table_1.xlsx-A_subsets-iMSC_fetal_MSC_UC_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Dihydroartemisinin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.84
4593_LIN52_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.626499
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K41451401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16444
NCIH2291	DepMap CRISPR Gene Dependency	1.0	2.31642
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.43853
BRD-K77663497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52649
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99100679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03803
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1565
MFE319_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	6.11431
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10769314-NIHMS1954782-supplement-9.xlsx-Table_S7B-Table_S7B_Frontal_cortex_relative_gene_expression_from_post-KD_and_pre-KD_recipient_mice_AR	Rummagene Transcription Factor Associations 2026	1.0	null
diclazuril	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35187
SGS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.001
PMC8423434-mmc7.xlsx-SOX2_HENSM-Genes_n_2733_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7782698-41467_2020_20367_MOESM9_ESM.xlsx-Student_s_t-test_BP1_ILK_GFP-Gene_names_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31936306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3303
Organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE153189_1_v_3_interferon gamma_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1395_BREAST	CCLE Cell Line Proteomics	1.0	2.75272
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
PMC8612733-elife-71982-fig7-data1.xlsx-Sheet1-3xFlag-YBX1_IP-MS_from_sheet2_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K30117087	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8394
WDFY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36178
CHRNA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.52347
non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC8185471-mmc7.xlsx-DEGs-SOX15_peaks-Day_6_SOX15-_-_upregulated_and_downregulated_genes_nearby_SOX15_CUT_Tag_top_10k_peaks_Related_to_Figure6_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_up-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08444
GSE233679_6_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20141
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9971
PCDHAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22966
BRD-K18316646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73577
WASH complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.991
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K50191826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14996
HOXB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4767
GSE197850_4_v_0_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250146
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.4134
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K82662168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02987
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE231648_0_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7830_SF3A1_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.69421
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1503
MORF4L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37016
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN017_MCF10A.TP53.M_24H:J04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.03769
BRD-K99516890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14936
Hypodermal seam cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.086
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2106
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.58071
IRF2BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9904
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K11893906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85083
LGALS9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00491312
CRCGN017_MCF10A.WT.HP_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3523
10123_ZIC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.539351
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.5587
GSE168697_0_v_1_wdr6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18166
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.02
RN486	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.53
PMC6930440-jcav11p0520s3.xlsx-MI_vs_FG-Unnamed_0_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE138818_1_v_0_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3B-Up_Dpy30_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
protein monoubiquitination	GO Biological Process Annotations 2025	1.0	null
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K61185334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42961
Mecom	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.1111
CRCGN010_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6371
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2999
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLF10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00403136
HCC95_LUNG	CCLE Cell Line Proteomics	1.0	4.09802
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K88856685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2676
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169205_4_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217873_1_v_0_nusap1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CSTF2T	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01388
CRCGN015_HEPG2_48H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.05721
BRD-K14987634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41595
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0335
PMC6157899-pgen.1007642.s019.xlsx-E2F1_Q4_Leading_Edge-Unnamed_6_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K38788176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85173
MDAMB453_BREAST	CCLE Cell Line Proteomics	1.0	2.74104
BRD-A64153357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14531
PAX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8827
protein ubiquitination	GO Biological Process Annotations 2025	1.0	null
DYNLT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.18973
ZBTB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54614
NCIH28	DepMap CRISPR Gene Dependency	1.0	4.89685
PA1	DepMap CRISPR Gene Dependency	1.0	3.01604
PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K95148987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3479
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K32195266	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.60487
GSE166315_1_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
6-chloromelatonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27742
BRD-K21547369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0451
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7065
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.76
BRD-K95457967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24015
WDR81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30619
Intracellular anatomical structure	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
NFATC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2304
RPSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37253
GSE178340_7_v_4_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178340_1_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K64317863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02111
GSE171180,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PROX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3887
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289956
NAA30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18987
Simvastatin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.56
PMC10153265-media-3.xlsx-BENPORATH_SOX2_TARGETS_v2023_1-STANDARD_NAME_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.35748
BRD-K36393312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33675
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0882
BRD-K15236933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38024
BRD-K10317744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33076
BRD-K73042446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59318
regulation of DNA replication	GO Biological Process Annotations 2023	1.0	null
ZBTB7A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0701
PYGL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00328428
GSE149870_0_v_1_pfn1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23589316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09691
BRD-K71496240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36697
GSE184884_4_v_1_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE207301,GSE207303_0_v_3_tp53bp2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:P15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.13794
BRD-K47087435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26426
BRD-K66539236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6466
MM160113	DepMap CRISPR Gene Dependency	1.0	3.72912
FGB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623115
BRD-K33104513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73039
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_2_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAF::NFE2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9422
PMC4149371-pone.0105180.s010.xls-SOX2-GENE_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
SCH	DepMap CRISPR Gene Dependency	1.0	4.30031
GSE224969,GSE224971_3_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE89018_10_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bradyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.354
BRD-K63030320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72247
MAPK12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0049594
UNC 0638	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.82
BRD-K12986423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0367
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3752
CRCGN015_MCF10A_48H:E15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14915
PMC10769395-media-2.xlsx-S2E_EF_Activated_genes-Ebegboni_et_al_Supplemental_Table_S2E_Decreased_expression_following_depletion_of_EWSR1_FLI1_TC-32_TC-71_and_A673_FLI1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Sirtinol_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141841
GSE123943_4_v_5_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SOHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8046
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-Unnamed_4_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRRX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0731
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC6157899-pgen.1007642.s019.xlsx-E2F1_Q4_Leading_Edge-E2F1_Q4_216_Genes_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67508052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01901
BRD-K67727634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34467
1941_CTPS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.749868
BRD-A71590475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.317
CRCGN015_HEPG2_48H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.93375
BRD-K53639581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76528
BRD-K07567566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03363
BRD-K72934808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09278
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11214527-mmc5.xlsx-TCF4-gene_TCF4	Rummagene Transcription Factor Associations 2026	1.0	null
COLO205	DepMap CRISPR Gene Dependency	1.0	4.34636
COPII vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
BRD-K84199148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02231
BMS 754807	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.67
BRD-K83949633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11939
GSE224969,GSE224971_0_v_1_chtop_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K91297952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17044
GSE114690_2_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K62358193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15571
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.722
BRD-K70039231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99709
P31FUJ	DepMap CRISPR Gene Dependency	1.0	2.02275
GSE195663_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYBL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66584
BRD-K29728947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48911
GSE164757,GSE164759_4_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K70289438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57552
GSE229978_4_v_7_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE164757,GSE164759_4_v_3_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Asi complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.822
TIRAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10082
GSE185922_1_v_2_riok2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A42579861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06977
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RAB6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38778
Oliva	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.96
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2194
GSE229580_0_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A20182314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37804
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF330	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44075
BRD-K86711517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38547
GSE223008_4_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mild cognitive impairment	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.026
BRD-A15798299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25329
BRD-K19808762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04396
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.03784
GSE75976_3_v_4_abl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K44339278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74834
BRD-K43292469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30812
Red bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.017
BRD-K35943892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43828
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K38929571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40128
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.001
BRD-K12359218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03465
EFNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61867
GSE96641_5_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Type I spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278539
ZNF687	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60946
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.6824
UQCC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09215
BRD-K47415214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40513
PMC12005766-ADVS-12-2413120-s003.xlsx-VENN1-Table_S6_related_to_Figure_S6D_List_of_overlapping_DEGs_with_the_E3_or_DUB_gene_set_from_the_iUUCD_2_0_database_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511093
HOXC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.5615
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2022
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.522185
BRD-K73540839	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.71943
Compartment syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.211
BRD-K71005143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41825
GSE134375_3_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60895802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14116
GSE169205_0_v_1_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158320,GSE183351_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PWP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58876
PMC8763317-MO-018-D1MO00236H-s002.xlsx-PHF21A_S0_1-Gene_names_PHF21A	Rummagene Transcription Factor Associations 2026	1.0	null
VAPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3698
BRD-K36709933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17451
BRD-K46820725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71527
TUBGCP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10734
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3499
BRD-K99028283	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22484
PSMD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00774496
GSE198165,GSE198166_5_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	154.057
KNS81	DepMap CRISPR Gene Dependency	1.0	2.23605
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.10092
YTHDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22947
BRD-K20039572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17049
496100323_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17928
BRD-K74968522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49835
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3635
BRD-K28739456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12934
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OVCAR4_OVARY	CCLE Cell Line Proteomics	1.0	2.89999
GSE86507,GSE86509_4_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12271646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.98753
Temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.052
E2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0529
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6911
KIAA0319L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07912
SNU423_LIVER	CCLE Cell Line Proteomics	1.0	2.68488
BRD-K40646662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56804
BRD-K73443280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18896
ZNF638	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14304
PMC4067464-onc2013378x3.xls-Sheet1-Supplementary_Table_1_Top_1000_E2F4_Chip-Seq_targets_that_are_repressed_by_p53_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53774433	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85039
7SK snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.069
PMC7618435-EMS211310-supplement-Table_S1.xlsx-C2-HSC_ELP_NR5A1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BMP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00675225
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
FGFR1OP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28578
GATA3-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Sunitinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.51
Nolatrexed	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.58
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_ZR75_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE146074_6_v_8_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7849364-supp_gad.342378.120_Supplemental_Table_S4_.xlsx-Hoja1-Table_S4-_SIX2-associated_genes_identified_by_CUT_RUN_overlapping_with_differential_expression_by_SIX2_knockdown_SIX2	Rummagene Transcription Factor Associations 2026	1.0	null
PF-431396	DeepCoverMOA Drug Mechanisms of Action	-1.0	-3.3
GSE146074_9_v_3_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Amsacrine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.82
BRD-K47049026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21957
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294109
C4II	DepMap CRISPR Gene Dependency	1.0	2.68211
GSE203158_5_v_14_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25295
CRCGN016_MCF10A.TP53.M_24H:N01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00545
BRD-A03997826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01064
GSE148200_4_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GATA6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0437
mRNA cleavage and polyadenylation specificity factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.595
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SPRYD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11169
BRD-K06367273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04925
BRD-K83238251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05603
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PLD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505097
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE132948,GSE132949_0_v_1_msi2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	39.5598
BRD-K77965546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84968
protein autoubiquitination	GO Biological Process Annotations 2025	1.0	null
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208413
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
RUNX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462998
GSE172019_2_v_3_rnf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61733751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75509
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBX2-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE86507,GSE86509_4_v_8_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MAP3K20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34614
BRD-K50216176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14552
PMC7614775-EMS178742-supplement-Proteomics_Table_1.pdf-112-GMEB2_GMEB2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K32418104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61596
ANKRD54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69776
GSE119978,GSE180930_6_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K58408512	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31036
Autosomal dominant cutis laxa	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.573
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300499
IFI30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19137
BRD-K81814927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68844
GSE144115_2_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pollen coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.813
BRD-K75073699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78616
GSE187006_0_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K49203165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.98239
GSE111247_14_v_10_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
LGI4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41994
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.1
CRCGN016_MCF10A.TP53.M_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23318
BRD-K60295429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19223
GSE154577_7_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27011412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99884
BRD-K21982562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.85369
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.6544
SNU1033	DepMap CRISPR Gene Dependency	1.0	3.60122
GSE74490_0_v_1_triptolide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.507751
BRD-K06279388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72782
PMC8423434-mmc7.xlsx-OCT4_Primed-Genes_n_912_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
Chromosome	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PMC7817097-abb9149_Table_S2.xlsx-293T-TET2-FLAG-Table_S2_Mass_spectrometry_results_for_endogenous_SMCHD1-FLAG_in_ES_cells_and_TET2-FLAG_in_293T_cells_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56868780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10179
LIVF001-002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0991
GSE172019_2_v_8_rnf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K63663384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0575
BRD-K75495990	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22202
CRCGN015_HEPG2_48H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.41065
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261905
Protein phosphatase 4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.191
PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287493
Chromatin	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN015_HEPG2_48H:B19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61831
BRD-K59970200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.27029
PMC10794847-mmc5.xlsx-PIAS1_KD_down-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Bladder small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
TP53	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572642
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K44492160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26572
BRD-K10698156	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55068
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K01643633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10352
BRD-K86039224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07888
GSE126345_7_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215086_8_v_6_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12909836-44318_2025_675_MOESM6_ESM.xlsx-DA_E605_PerS1_M1_10_MQ-noMBR_MR-Unnamed_3_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K88135858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.25609
WBP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0682
BRD-A13082766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.63456
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K14262397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47603
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1069
PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_NANOG_targets_Boyer_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Nearest_Ensembl_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.099
PMC12186250-NIHMS2085662-supplement-3.xlsx-4111_TEAD4_peaks-Gene_Name_TEAD4	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K60507129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.008
LUC_FBS	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54573
BRD-K78983822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98125
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K61711624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09895
CRCGN015_MCF10A_48H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09361
BRD-K13370005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21477
BRD-K05154886	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44511
CRCGN015_HEPG2_48H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2736
BRD-K11057086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54918
Stat6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.7198
UPK3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89632
BRD-K18101567	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19106
GSE200982_0_v_2_plac8_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:B20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18396
Dcp1-Dcp2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.74
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.44353
PRDM13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42754
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51233
levallorphan-tartrate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69038
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.273
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ATP1B4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00698894
GSE208254_3_v_2_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7465
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	63.92
GSE149264,GSE149267_4_v_5_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12069319-Table1.xlsx-OCAB_p35_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K73290515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77951
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.639
BRD-A69648159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09192
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE195743_3_v_2_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TCEA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30164
Dbf4-dependent protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.192
GSU	DepMap CRISPR Gene Dependency	1.0	2.16165
PMC3923219-mmc2.xls-Table_S1-Table_S1_Differential_Gene_Expression_in_GFP-PRDM1_transduced_H9_hESCs_PRDM1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92365616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07789
BRD-K71919612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50555
UBE2D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3857
HOXB2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.7119
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	45.8746
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03884
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
AIFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37602
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18547
Factor VIII deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.854
NT5DC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00387985
Stat4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3509
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229070,GSE229071_0_v_2_sotorasib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K65005022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11987
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE211286_4_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K61020385	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24735
GSE112760,GSE112767_4_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138001_5_v_4_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MAP3K6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40764
UFD1-NPL4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.89
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.297891
PMC6157899-pgen.1007642.s019.xlsx-E2F1_Q4_Leading_Edge-Unnamed_24_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61978712	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59509
GSE100102_0_v_5_cgas_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE151090_0_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Inferior olivary complex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.168
Cellular anatomical entity	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Factor XI deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
GSE86507,GSE86509_7_v_5_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DDX49	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57867
GOLGA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67032
PMC6604319-13072_2019_278_MOESM3_ESM.xlsx-CEM_ect_TET2_DEGs_DMRs_hDMRs-CCRF-CEM_EV_vs_ectopic_TET2_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
Type IC spiral ganglion neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K15474464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28385
PMC8052288-mmc4.xlsx-PAF_DREAM_targets_H1792-Unnamed_1_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
Lower epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.513
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ubiquitin-protein transferase activity	GO Molecular Function Annotations 2025	1.0	null
GSE149355_0_v_1_esrp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Tube foot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.04
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10244410-41467_2023_39054_MOESM5_ESM.xlsx-PIE-LIN28B-GeneSymbol_LIN28B	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
pre-replicative complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.621
PM20D2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01248
BRD-K34815008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82422
GSE122067_3_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE102505_1_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.5204
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6863
GSE214823,GSE214824_3_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-13q34_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K50851442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96336
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-PAX6_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
HOXA7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.2363
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145311_1_v_2_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178340_1_v_9_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11832
BRD-K95798946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17656
NUP160	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27652
GSE254649_3_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K02388444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10405
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0482
GD-66-XE49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.25434
JM1	DepMap CRISPR Gene Dependency	1.0	6.24447
NOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.43214
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K83436911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44685
GSE186483_2_v_0_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:B03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.388
GSE211177,GSE211178_0_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GINS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.204
BRD-K35462787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51955
BRD-K41714444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26677
9-Aminocamptothecin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-2.88
HUPT4_PANCREAS	CCLE Cell Line Proteomics	1.0	2.66935
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0035
CRCGN015_MCF10A_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1201
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5234
GSE151782_6_v_7_aim2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Inferior olivary nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.274
GSE143944_2_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178532_2_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9424213-41467_2022_32537_MOESM6_ESM.xlsx-siHNRNPK_cyto-DEGs_for_hnRNPK_KD_cytoplasmic_RNA_of_HeLa_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KCIMOH1	DepMap CRISPR Gene Dependency	1.0	2.33114
GSE150669_0_v_1_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Pronephros	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K94913508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12701
THOC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49087
RALB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2279
PKMYT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613655
BRD-K85232515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92335
8467_ST20-MTHFS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.57928
GSE223008_4_v_12_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27788
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6073
PMC5989213-41467_2018_4462_MOESM8_ESM.xlsx-3-Supplementary_Data_3_List_of_2687_genes_differentially_expressed_between_SETBP1-G870S_and_Empty_293_FLP-In_lines_SETBP1	Rummagene Transcription Factor Associations 2026	1.0	null
STAT1::STAT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3387
BRD-K08442552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31306
CCR4-NOT core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.132
BRD-K29218981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03584
GSE158834_2_v_9_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE217115_2_v_4_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Podosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.058
HERC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50464
BRD-K93335719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46677
GSE216043_7_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K40088786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60004
GSE211177,GSE211178_8_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K59272984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86751
GSE192689_0_v_1_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.4823
PMC6142327__F3	PFOCR Pathway Figure Associations 2023	1.0	null
BAG6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11812
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.56596
ZNF311	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60242
BRD-K76600600	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19856
GSE173810_0_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K56024344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52148
Kidney - Medulla	GTEx Tissue Gene Expression Profiles 2023	1.0	3.58428
GSE135350_2_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K18313650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19707
BRD-K79222491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86358
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE148066,GSE157787_8_v_7_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE220914_2_v_0_zdhhc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K80622681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42014
BRD-K50685439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21099
CRCGN017_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5347
PMC7672319-mmc3.xlsx-DREAM_MSigDB62-FISCHER_DREAM_TARGETS_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
HDMYZ	DepMap CRISPR Gene Dependency	1.0	2.63406
SAM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.22
BRD-K67525206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90597
CRCGN010_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0405
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCIXC	DepMap CRISPR Gene Dependency	1.0	9.18921
GSE210885_0_v_7_klf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K50435683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30172
GSE231641_0_v_1_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of DNA metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE228413_2_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bafilomycin A1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.22
BRD-K77978259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.39406
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	343.893
BRD-K36314834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20585
GSE220520_5_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.307412
CHCHD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06239
bp94	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.286
EHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25843
PMC6545597__F1	PFOCR Pathway Figure Associations 2024	1.0	null
MKN1_STOMACH	CCLE Cell Line Proteomics	1.0	2.37911
CAF-1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.052
GSE102505_6_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K17176016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45743
GSE114690_2_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4571
GSE157555,GSE157556_3_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1716
Intracellular non-membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08796
BRD-K13681383	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7949
GSE146982_4_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_ZSCAN4-Unnamed_3_ZSCAN4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Unnamed_1_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
HEY1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.1401
CRCGN015_MCF10A_48H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	8.37587
BRD-K87141723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9845
5762_NPAT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06141
PMC11073998-41375_2024_2235_MOESM9_ESM.xlsx-THP1_phosphoproteome-Unnamed_2_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10153265-media-3.xlsx-BENPORATH_OCT4_TARGETS_v2023_1-STANDARD_NAME_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC2813300-pone.0008960.s011.xls-SOX2_targets_in_human_ESCs-Gene_Symbol_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE107505_3_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86004174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02912
GSE188458_2_v_4_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07274638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11974
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAEA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05663
BRD-K48332223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20629
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81888673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04035
PMC12229934-ab-24-0809-Supplementary-2.pdf-15-MYSM1_MYSM1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K38084509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05846
NKX6-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0881
PMC5444746-oncotarget-08-30328-s002.xlsx-SI01_ChIPSeq_H3K9me_AR-Gene_Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Vitelline envelope	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.74
GSE214823,GSE214824_4_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186483_6_v_4_lrrk2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HeLa-S3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.139
SU8686_PANCREAS	CCLE Cell Line Proteomics	1.0	2.4717
BRD-K81370109	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10541
Chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GLIPR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13019
PMC10679662-mmc3.xlsx-NC-D3-ZEB2-Mutant-Downregulated-Unnamed_7_ZEB2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85720719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37699
BRD-K17889110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34034
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4367
BRD-K03821002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94968
BRD-K08000110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72475
BRD-K05068331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66044
Gedatolisib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.67
CRCGN016_MCF10A.TP53.M_24H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01871
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210682_2_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_SOX2_targets_Boyer_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K62584372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29182
BRD-K60751806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07272
HEK-293F cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.644
NBI-74330	DeepCoverMOA Drug Mechanisms of Action	1.0	0.38
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K63665694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0382
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:O16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23089
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8388
E2F8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6445
ALX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06329
BRD-K35308744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31279
GSE116930,GSE116935_3_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2282
BRD-K13320013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29533
ARHGDIA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0234
BRD-K55209210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51108
GSE173810_4_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293383
TFAP2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46726
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	141.46
GSE89767_1_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.14115
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.44697
GSE196540,GSE196542_2_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE181513_0_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TKT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29959
GSE210101,GSE210114_6_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K12384030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00224
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TC32	DepMap CRISPR Gene Dependency	1.0	6.47999
BRD-K14756138	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01789
BRD-K01263144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62792
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
Excretory canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.398
Intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MAP3K6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512678
EXOSC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06838
BRD-K51697315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7101
BRD-K54647312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08858
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MAVER1	DepMap CRISPR Gene Dependency	1.0	2.12283
BRD-K62017257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21445
GSE86507,GSE86509_7_v_2_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0155
BRD-K94728263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03118
GSE114992,GSE114993_4_v_2_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VENTX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7074
IBTK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57811
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.5512
GSE186767_1_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE181513_2_v_1_usp7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K69580972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.1785
IRX6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00027
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.112
CRCGN010_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3491
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	118.256
GSE147210_3_v_4_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TIMM23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11421
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.0065
PMC11263707-41419_2024_6896_MOESM4_ESM.pdf-14-TCF7L2_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K32063762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0171
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE188832,GSE188835_0_v_1_irf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213410_0_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15099225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12106
CDC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07115
PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8	Rummagene Transcription Factor Associations 2026	1.0	null
PSORS1C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0494
CRCGN015_MCF10A.TP53.M_24H:F07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1003
GSE149264,GSE149267_2_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HEL9217	DepMap CRISPR Gene Dependency	1.0	4.23358
BRD-K47926785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88389
BRD-K37379978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30378
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	162.56
TTC549	DepMap CRISPR Gene Dependency	1.0	2.07094
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7754
ZNF786	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18459
BRD-K13888422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30484
GSE169697,GSE169725_1_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K39099034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43006
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_3_GSC	Rummagene Transcription Factor Associations 2026	1.0	null
NCK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74227
K562_Temsirolimus_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142403
BRD-K72484719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.66732
GSE199644_3_v_2_palmitic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07525144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31343
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	1.0	null
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.37254
LIVF001-017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38343
UPMD1	DepMap CRISPR Gene Dependency	1.0	2.45079
BRD-K55815187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15436
GSE146074_9_v_11_ly6e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K80212510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00589
GSE248045,GSE248046_4_v_2_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BBSome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.752
BRD-K86912219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50628
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K98639224	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21541
GSE173810_0_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K18645499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24087
SP2/0-AG14 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.699
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7822
BRD-K04219533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44618
CBFA2T3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0322
GSE214823,GSE214824_3_v_1_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Actin rod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.576
GSE148269,GSE148273_0_v_1_arid4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K28535931	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.233
BRD-K03957217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16111
BRD-K23440419	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12657
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.052
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K04786080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04649
succinate-CoA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.543
BRD-K10761381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59562
NCIH1573_LUNG	CCLE Cell Line Proteomics	1.0	9.53716
PMC9212771__F6	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K84601599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32451
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RH30	DepMap CRISPR Gene Dependency	1.0	4.98738
PNMA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.37753
CRCGN011_HEPG2_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34655
GSE126777_3_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CD164L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13868
GSE178340_1_v_6_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210225_0_v_1_uba6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
STOML1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26877
SNU1077	DepMap CRISPR Gene Dependency	1.0	2.05549
GSE149264,GSE149267_9_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.04914
Limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.052
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06129
PMC11528209-cd-23-1212_supplementary_table_s7_suppst7.xlsx-A549_EML4_KD_DEGs-List_of_DEGs_of_EML4-knockdown_vs_control_A549_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE152432_9_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K08799663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1672
BRD-K73387470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74527
IPC298	DepMap CRISPR Gene Dependency	1.0	3.08775
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
308_ANAPC4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.523314
BRD-K63065496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03589
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HOXD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.5899
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.052
Saracatinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.47
BRD-K17128952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07106
GSE254770_0_v_1_sin3b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
C9orf78	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75881
BRD-K75065750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33233
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MEL270	DepMap CRISPR Gene Dependency	1.0	5.31058
GSE249098_1_v_2_mthfd1l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6286
Methylosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.295
BRD-K91079447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21016
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4398
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE63048_11_v_6_morc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.5361
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K72932441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12784
PMC12019345-41598_2025_98989_MOESM10_ESM.xlsx-Sheet_1-CCNE2_related_genes_AND_HNSCC_HNSCC_DDP_NOT_DDR_Genes_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K90858591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27818
RASA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19888
GSE188458_2_v_0_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K62202988	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70337
BRD-K20906316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76193
NSL complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.05
PMC12549544-mmc2.xlsx-AA_D7_VS_D14-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PRPF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29125
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81501934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64792
GSE130396_1_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_22-Supplementary_Table_22_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_Beat-AML_cohort_TET2	Rummagene Transcription Factor Associations 2026	1.0	null
GSTM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68297
TRUB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07577
BRD-K46970272	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57503
BRD-A95683194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70168
BRD-K51050934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18554
CRCGN017_MCF10A.WT.HP_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18605
BICR10	DepMap CRISPR Gene Dependency	1.0	3.03606
Hemarthrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
Origin recognition complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.73
BHLHE40	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4276
GSE128076_2_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5532
Mitotic arrest phase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.052
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11145
HES5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0989
RPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74159
GSE102870_7_v_0_nr1h4_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC6433297-pbio.3000178.s012.xlsx-DREAM_targets-BUB1B_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.4132
PMC10153265-media-3.xlsx-BENPORATH_NANOG_TARGETS_v2023_1-STANDARD_NAME_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
GSE235701,GSE261434_0_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.648673
CAPAN1	DepMap CRISPR Gene Dependency	1.0	5.59174
MYO5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86524
BRD-A21584932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04326
PMC6157899-pgen.1007642.s019.xlsx-E2F1_Q4_Leading_Edge-Unnamed_12_E2F1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75688032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65341
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE117042_1_v_3_tunicamycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164884_2_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC2742312-1479-7364-3-3-221-S3.PDF-275-KLF12_KLF12	Rummagene Transcription Factor Associations 2026	1.0	null
8126_SLU7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13745
GNPTAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3994
BRD-K07802542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43275
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_9-Supplemental_Table_9_Limma_DE_Analysis_of_HC_AA_to_EA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
BFTC909	DepMap CRISPR Gene Dependency	1.0	2.63588
PMC7098486-mmc2.xlsx-Kgg_Quant_NGN2_AAVS_-_WCL-Unnamed_2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13898728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88421
VSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5703
9886_XAB2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.551554
GSE123943_2_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K00350773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65999
BRD-K73841784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02696
PRKRA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04262
BRD-K66963756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07494
BATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7543
protein monoubiquitination	GO Biological Process Annotations 2023	1.0	null
PTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05113
BRD-K69840402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60139
BRD-A99687212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24533
cofilin-actin rod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.699
ASAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74936
BRD-K66823946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56957
496100485_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.48838
Root quiescent center	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.6
BRD-K85572169	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69145
GSE126777_0_v_1_otub1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K15997423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51688
BRD-K19264579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75508
ACOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10467
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.770317
DDX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.697
BRD-K00611112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22682
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TMEM42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07331
BRD-K93516545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25932
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178340_7_v_9_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157555,GSE157556_0_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K27320944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06056
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.003
LHX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0048
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
2833_FAM111A_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500366
Response to statin therapy	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.530103
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC5444746-oncotarget-08-30328-s002.xlsx-SI02_Gene_symbols-1912_ChIP-Seq_H3K9me1_2_demethylation_and_ChIP-Seq_AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K71631414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81486
GSE242647_2_v_3_adiponectin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11131031-pwad060_suppl_supplementary_tables_s3.xlsx-FOXO1-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO1-_-_vs_FOXO1_hMSCs_FOXO1	Rummagene Transcription Factor Associations 2026	1.0	null
LB1047RCC	DepMap CRISPR Gene Dependency	1.0	3.53446
GSE136894_1_v_0_psen1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202284,GSE202289_5_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NOTO	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4708
Neuronal ribonucleoprotein granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.648
GSE155162,GSE155169_1_v_3_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_1_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6847
PMC6853299-pbio.3000476.s011.xlsx-Fig_4A-HVC_612_gene_expression_ratio_in_ZF_and_OF_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86964464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48526
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4634137-ncomms9549-s7.xlsx-ZF_Hair_cell_data-Unnamed_1_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K41875112	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80899
RFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00417
GSE212486,GSE212488_2_v_3_gata4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
GSE166294_0_v_1_etv5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE241701_4_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K51490423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62713
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE148657_2_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.91995
BRD-K06399794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43771
DUS1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14056
BRD-K65440031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27143
GSE199644_3_v_1_palmitic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CHLA90	DepMap CRISPR Gene Dependency	1.0	3.209
6625_PPIE_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.611833
PMC9195629-Table1.xlsx-Supplementary_Table_1-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89018_1_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K03697080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20885
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.1107
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-DREAM_target_genes_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8040704-jcav12p2673s2.xlsx-Down-regulated_genes_in_EBF1-Unnamed_0_EBF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233679_6_v_13_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Replication fork protection complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.83
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.82094
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1215
EIF2AK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00472129
GATA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.0781
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE157555,GSE157556_5_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8763317-MO-018-D1MO00236H-s002.xlsx-PHF21A_S0_2-Gene_names_PHF21A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE139540_3_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Tachyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.117
BRD-K31024887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22562
PMC5895607-41388_2017_42_MOESM4_ESM.xls-geneNames-Extended_Data_3_Gene_list_of_SRC-1_targets_which_contain_STAT1_binding_motifs_from_LY2_cell_RNAseq_data_STAT1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K67998155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17996
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Prdm4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.9187
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K99447506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16182
BRD-K04495110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69496
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.245
CRCGN014_HEPG2_3H:C02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17089
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE102505_6_v_3_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GYG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51791
PMC6347712-pnas.1812449116.sd05.xlsx-iPSC_IRF7_48h_RNAExpress-Gene_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null