association dataset threshold value standardized value GTEX-UPJH-0126-SM-4IHLL GTEx Tissue Sample Gene Expression Profiles 1.0 2.11404 Spindle pole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.06 FA-88-II68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.355833 fulvestrant-310 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TB-06-VB30_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.256986 GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91367 17504995-TableS3 GeneSigDB Published Gene Signatures 1.0 null bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.222392 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.923446 ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-1326-SM-4AD5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.22584 H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042873 GTEX-S32W-1526-SM-4AD6Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.06492 Lung squamous cell carcinoma_LUSC_TCGA-94-A5I4-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR Rummagene Transcription Factor Associations 2026 1.0 null MIS12/MIND type complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.726 GSE264621_1_v_6_secretin_human RummaGEO Drug Perturbation Signatures 1.0 null GB-06-BA49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.462288 Intraciliary transport particle A COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.401 EGFR_druginhibition_83_GSE27640 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.66675 DAOY CCLE Cell Line Gene CNV Profiles 1.0 1.52269 COPS9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3092 POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11983 Primary autosomal recessive microcephaly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.868 HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN013_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.91075 19204204-SupplementaryTable6 GeneSigDB Published Gene Signatures 1.0 null ELF1 ENCODE Transcription Factor Targets 1.0 null SIMA GDSC Cell Line Gene Expression Profiles -1.0 -1.61381 GSE184884_7_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.56012 GSE203362_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE192870_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null Primary somatosensory area, barrel field, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.25052 H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_9_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null K562_Tubastatin A HCl_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0196171 PMC3076323-pone.0018064.s016.xls-MYCN_targets_Marson_GSE6007-Unnamed_1_MYCN Rummagene Transcription Factor Associations 2026 1.0 null CTCF_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sotalol-2918 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE145311_0_v_2_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE137702_2_v_4_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36348 H3K4me1_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH1299 CCLE Cell Line Gene Expression Profiles 1.0 1.88068 MCF7_Disulfiram_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0114909 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-6692-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Axoneme COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.423 H4K5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null cinnarizine-5817 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RFX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148321,GSE169423_0_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null amygdaloid complex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.906778 PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X5EB-0426-SM-46MVY GTEx Tissue Sample Gene Expression Profiles 1.0 0.896568 K562_SRT3025 HCl_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016037 FOS ENCODE Transcription Factor Targets 1.0 null GTEX-TKQ1-0926-SM-4DXU2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.79827 H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE136869_1_v_0_lpar2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null cerebellar cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.832838 TAF7 ENCODE Transcription Factor Targets 1.0 null G361 CCLE Cell Line Gene CNV Profiles 1.0 1.39547 GSE211177,GSE211178_4_v_3_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K79me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Bicalutamide_A498 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0108393 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20_vs_D1_815_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE158969_1_v_2_trastuzumab_human RummaGEO Drug Perturbation Signatures -1.0 null cilium GO Cellular Component Annotations 2025 1.0 null nuclear-proteins Phosphosite Textmining Biological Term Annotations 1.0 null Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.83605 Epididymal fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.502 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.051411 lymph node HPA Tissue Gene Expression Profiles 1.0 0.868134 NB12 COSMIC Cell Line Gene Mutation Profiles 1.0 null Nucleus of the lateral olfactory tract, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.09403 12097256-Table2 GeneSigDB Published Gene Signatures 1.0 null GSE103068_0_v_4_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null E2F4 ENCODE Transcription Factor Targets 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCLAF1 ENCODE Transcription Factor Targets 1.0 null BmN4-SID1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.236 pentamidine-4396 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null adrenosterone-5045 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null abnormal reproductive system morphology MPO Gene-Phenotype Associations 1.0 null GSE161846,GSE161849_4_v_0_smarca4_human RummaGEO Gene Perturbation Signatures 1.0 null GSE176008_8_v_1_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE229973_3_v_6_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null VIIIA Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15698 PMC8528285-pbio.3001085.s010.xlsx-Fig_S7A-GENE_LIST_UPLOADED_TO_ENRICHR_MLX_TESTES_855_GENES_MLX Rummagene Transcription Factor Associations 2026 1.0 null hypersensitivity reaction disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.045278 imatinib_homo sapiens_gpl96_gds3043 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE197117_0_v_1_kdm6b_mouse RummaGEO Gene Perturbation Signatures -1.0 null MCF7_KW-2449_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156039 ezetimibe_mus musculus_gpl2995_gse39813 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-52-7809-01A-21R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KM12 COSMIC Cell Line Gene Mutation Profiles 1.0 null MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Obesity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.028 Ciliary rootlet COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.289 neuro2a BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07371 axoneme part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 GSE239844_11_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.72948 Parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17277 REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null controls GeneRIF Biological Term Annotations 1.0 null pseudopelletierine-2766 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC13000489-mmc1.xlsx-Table_S3-Table_S3_LC_related_genes_screened_by_MR_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE146074_0_v_3_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE147366_1_v_4_med13_human RummaGEO Gene Perturbation Signatures -1.0 null PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR Rummagene Transcription Factor Associations 2026 1.0 null F-actin capping protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.325 SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.7581 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OHPM-0008-SM-4E3IP GTEx Tissue Sample Gene Expression Profiles 1.0 0.888972 molecular layer of CbVCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4805 mammalian phenotype MPO Gene-Phenotype Associations 1.0 null PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2 Rummagene Transcription Factor Associations 2026 1.0 null Urinary Bladder Neoplasms CTD Gene-Disease Associations 1.0 1.20784 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08538 intracellular part GO Cellular Component Annotations 2015 1.0 null HT-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25884 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.960218 regulation of organelle assembly GO Biological Process Annotations 2025 1.0 null PMC11399402-41598_2024_72406_MOESM3_ESM.pdf-2-NFKB1_NFKB1 Rummagene Transcription Factor Associations 2026 1.0 null demeclocycline-3706 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31302 TestisSeminiferousTubule BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.27508 hematologic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.059615 hsa-miR-23b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GSE111247_2_v_7_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null heat-shock-proteins Phosphosite Textmining Biological Term Annotations 1.0 null GSE214596,GSE214598_1_v_4_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null K562_Thalidomide_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0201909 cerebellar cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.865271 H3K79me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE203329_0_v_1_mettl5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE240439_1_v_0_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27me3_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE112760,GSE112767_4_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.645287 FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null IPO13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62088 CFPAC-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.95139 furaltadone-3756 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney Chromophobe_KICH_TCGA-KN-8427-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100463_FWM_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.23004 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3EV-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNOS-1026-SM-4DM4Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.92183 Epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.883 POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null whole plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.367129 Lung squamous cell carcinoma_LUSC_TCGA-58-8388-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Motesanib Diphosphate_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0152165 Cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.543 Interposed nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12333 GSE261563_6_v_1_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 15260889-TableS2a GeneSigDB Published Gene Signatures 1.0 null TestisLeydigCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.0516 GTEX-PWCY-1426-SM-48TCT GTEx Tissue Sample Gene Expression Profiles 1.0 1.07023 proto-oncogene-proteins Phosphosite Textmining Biological Term Annotations 1.0 null K562_Mesna_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0220397 MAP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14247 A-Netherlands-602-2009(H1N1)_12Hour_None_GSE40844 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.9633 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41764 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A_48H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3476 USF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80Y-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4326-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100455_FWM_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.04706 KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JC-2326-SM-32PMR GTEx Tissue Sample Gene Expression Profiles 1.0 1.25418 AG-013608-6440 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DIFI DepMap CRISPR Gene Dependency 1.0 2.0846 nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052416 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A499-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.07657 H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GTEX-P4PQ-1026-SM-3NMCN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.84514 foxa1_21151129_mcfdash7_lof_human_gpl10558_gse25315 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.201069 hsa-miR-3136-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 10737_ZWILCH_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.540156 GSE112762,GSE112767_1_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null MCF7_ZM 447439_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016497 GTEX-S7PM-0011-R6A-SM-3NM8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21172 GSE58724_1_v_0_oxymetholone_mouse RummaGEO Drug Perturbation Signatures -1.0 null pindolol-2075 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hsa-miR-370 TargetScan Predicted Conserved microRNA Targets 1.0 0.766596 GSE168797_2_v_0_cannabidiol_human RummaGEO Drug Perturbation Signatures -1.0 null BB-93-VT73_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.505796 EPI-2610-1 (BAG2) NURSA Protein Complexes 1.0 null Sperm flagellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.54 XC-81-LR46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.36596 cerebellar cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08965 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U8XE-0526-SM-3DB8R GTEx Tissue Sample Gene Expression Profiles 1.0 0.887149 CACO-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.951937 hsa-miR-520c-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 NCIH1876 CCLE Cell Line Gene CNV Profiles 1.0 2.09025 GSE149000_2_v_0_cyp3a5_human RummaGEO Gene Perturbation Signatures -1.0 null Lobule III, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60669 RELA ENCODE Transcription Factor Targets 1.0 null RXRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 51.8015 K562_Anacardic Acid_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0190786 Epididymosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.405 GSE181513_2_v_1_usp7_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.846954 sulfapyridine-7151 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null heart GTEx Tissue Gene Expression Profiles -1.0 -0.963054 PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null AC-74-ZA35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.594849 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211151_1_v_0_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null chr9_128509958_CA_C_b38 GTEx eQTL 2025 1.0 1.49609 Prestwick-967-4250 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null urinary bladder cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.201962 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21606 GSE149366_1_v_0_sulconazole_human RummaGEO Drug Perturbation Signatures 1.0 null BICR56 CCLE Cell Line Gene Expression Profiles -1.0 -1.85627 BL2385 (ERCC4) NURSA Protein Complexes 1.0 null cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.92372 hsa-miR-3192 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GTEX-RVPV-0008-SM-47JYW GTEx Tissue Sample Gene Expression Profiles 1.0 1.21576 MCF7_Aurora A Inhibitor I_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179851 PSME3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35245 lateral parabrachial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07224 sulindac sulfide-308 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null lumicolchicine-4195 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE211177,GSE211178_0_v_11_ets1_mouse RummaGEO Gene Perturbation Signatures -1.0 null dequalinium chloride-2631 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE154074_2_v_0_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.986135 GSE166920_6_v_2_adalimumab_human RummaGEO Drug Perturbation Signatures -1.0 null primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05447 GTEX-S4P3-1626-SM-3K2AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.916345 Cell Cycle Reactome Pathways 2014 1.0 null H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MFE-319 COSMIC Cell Line Gene Mutation Profiles 1.0 null naftopidil-4193 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SP3_Deficiency_GDS3058_610_mouse_Embryonic heart (day 12.5 C57Bl/6) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null amygdaloid complex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.20554 SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.910031 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null teratocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.71542 MCF7_Valproic acid sodium salt_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0148569 GTEX-PLZ6-0006-SM-33HBZ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14275 REC1 CCLE Cell Line Gene Expression Profiles 1.0 1.93716 Aster COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.606 MYCN ChEA Transcription Factor Targets 1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.66962 SRF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NB10 GDSC Cell Line Gene Expression Profiles -1.0 -1.46986 Caput epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.057 GSE120612_4_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null microtubule GO Cellular Component Annotations 2015 1.0 null GTEX-TKQ2-1526-SM-4DXUN GTEx Tissue Sample Gene Expression Profiles 1.0 2.55101 NR3C1 JASPAR Predicted Transcription Factor Targets 1.0 null GSE120413,GSE120447_3_v_5_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null sublayer 6a of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28245 hsa-miR-3682-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.632343 embryonic lethality prior to tooth bud stage MPO Gene-Phenotype Associations 1.0 null FOSL2::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.6874 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null dihydroergotamine-1398 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE245270_1_v_5_isoproterenol_human RummaGEO Drug Perturbation Signatures 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null GSE193993_1_v_3_sstr2_human RummaGEO Gene Perturbation Signatures -1.0 null amiloride-4109 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PMC6433297-pbio.3000178.s012.xlsx-DREAM_targets-BUB1B_KCNIP3 Rummagene Transcription Factor Associations 2026 1.0 null non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.536594 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T2-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE246195,GSE246305_2_v_0_sin3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE102505_4_v_2_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A.TP53.M_24H:A08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.5684 GSE101546_3_v_5_setdb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Crus I, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.845 diabetes mellitus GWASdb SNP-Disease Associations 1.0 0.311642 amygdaloid complex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.02875 E2F6_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null levcycloserine-3789 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FOXM1 ENCODE Transcription Factor Targets 1.0 null internal granular layer of CbVCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56148 GSE254649_3_v_0_cstf2_human RummaGEO Gene Perturbation Signatures -1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Inner dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.216 K562_Prednisone_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149391 Olfactory tubercle, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66344 CRCGN012_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.29994 POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null developmental process GO Biological Process Annotations 2015 1.0 null UBTF ENCODE Transcription Factor Targets 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RM2N-1626-SM-2TF5N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829475 9962_ZBED2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.520605 GSE125014_6_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV MA15_Day1-PFU-10^5_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.80602 lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Pt-K1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.768 H3K27me3_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEG-01 GDSC Cell Line Gene Expression Profiles 1.0 1.76219 GTEX-WL46-2826-SM-3LK81 GTEx Tissue Sample Gene Expression Profiles 1.0 0.912663 K562_CUDC-907_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150926 lateral hypothalamic area, mammillary region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.935842 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M3-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null staurosporine-312 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE161846,GSE161849_1_v_0_smarca4_human RummaGEO Gene Perturbation Signatures 1.0 null 9+2 motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.739 Pyramus (VIII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.68143 CRCGN013_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.52175 myosmine-4293 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE128730_4_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE169152_3_v_7_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null Sperm head plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.111 PMC5848610-supp_gr.228809.117_Supplemental_Table_S3.xlsx-Table_S3F-Supplemental_Table_S3F_ZFX_binding_pattern_clustering_information_for_genes_with_promoters_bound_by_ZFX_related_to_Figure_2I_ZFX Rummagene Transcription Factor Associations 2026 1.0 null FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null TIMM17A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12172 Paramedian lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.97457 posteroventral (inferior) parietal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.41855 PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Rigosertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0174561 AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null plk1 Phosphosite Textmining Biological Term Annotations 1.0 null GSE114883_0_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.915827 thiamphenicol-1867 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null doxazosin-3024 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Nephronophthisis 18 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.144 MCF7_Temsirolimus_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147707 pallidal part of olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.87058 Brain Lower Grade Glioma_LGG_TCGA-HT-A61C-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Trametinib_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167955 septostriatal transition area (accumbens) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.13644 auditory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.27687 GTEX-RN64-2326-SM-48FDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.51731 Deuterosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.955 H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE119978,GSE180930_6_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null anatomical structure development GO Biological Process Annotations 2015 1.0 null Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 spindle pole COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 cby GeneRIF Biological Term Annotations 1.0 null CB-16-SY72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.308849 Photoreceptor connecting cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.823 cefixime-1310 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.61636 cyclopentolate-5734 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null chlorprothixene-2627 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null G402 DepMap CRISPR Gene Dependency 1.0 2.17337 GSE142210_2_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null phosphos796 GeneRIF Biological Term Annotations 1.0 null MCF7_Dasatinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137224 PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-Gene_Symbol_RARG Rummagene Transcription Factor Associations 2026 1.0 null GSE146962_0_v_1_glucosamine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE211177,GSE211178_9_v_11_ets1_mouse RummaGEO Gene Perturbation Signatures -1.0 null parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20974 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mastigoneme COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.613 POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN017_MCF10A.WT.HP_24H:P10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.6503 EM2 CCLE Cell Line Gene CNV Profiles -1.0 -2.08037 Primary somatosensory area, lower limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81081 GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDK19_knockdown_162_GSE38061 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.13431 JAK1_druginhibition_166_GSE38335 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.24304 G2/M Transition Reactome Pathways 2024 1.0 null stem TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.431077 PMC6786946-NIHMS1535503-supplement-3.xlsx-SAT1_2_0x-FOXM1_genes_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null motile GeneRIF Biological Term Annotations 1.0 null remoxipride-6342 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cerebellar cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.22195 GSE193258,GSE193259_9_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VIIAf Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.864383 PRRC2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38147 laterostriatal stripe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.88801 Omeprazole (sodium)_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0125998 A549_Resveratrol_1µM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145084 hexetidine-6319 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HELA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.4984 GSE180800,GSE180801_0_v_5_tex10_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06731 GSE144231_2_v_7_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE125014_1_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_2-Methoxyestradiol_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148019 caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.57213 OB-06-WW76_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.990344 JDP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.2199 posteroventral (inferior) parietal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.901057 Lung adenocarcinoma_LUAD_TCGA-55-7913-01B-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null biological_process GO Biological Process Annotations 2015 1.0 null infertility MPO Gene-Phenotype Associations 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29L-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NE-29-VB58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.358963 KDM5B-21448134-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Mitotic G2-G2/M phases Reactome Pathways 2014 1.0 null Vestibular sensory epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.693 FOXA1 ENCODE Transcription Factor Targets 1.0 null BPH-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-135b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.636 RC-K8 COSMIC Cell Line Gene Mutation Profiles 1.0 null K562_Cimetidine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0265441 occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.58334 motile cilium COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 A549_Ki8751_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0163497 CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE164529_0_v_3_tamoxifen_human RummaGEO Drug Perturbation Signatures -1.0 null GSE164529_0_v_2_tamoxifen_human RummaGEO Drug Perturbation Signatures -1.0 null EPHA7 MSigDB Cancer Gene Co-expression Modules 1.0 null organelle GO Cellular Component Annotations 2015 1.0 null GSE228017_0_v_1_parthenolide_human RummaGEO Drug Perturbation Signatures -1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MCF7_Luminespib_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0102225 CRCGN016_MCF10A.WT.HP_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.41814 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ciliary basal body COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.727494 MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_10_v_5_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.999045 GSE115542_2_v_4_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0599 VIIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.975642 cellular phenotype MPO Gene-Phenotype Associations 1.0 null CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.925049 K562_Ki8751_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0175586 GSE205976,GSE205978_1_v_0_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XUYS-0002-SM-47JXL GTEx Tissue Sample Gene Expression Profiles 1.0 0.824154 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUN_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE160442,GSE160444_4_v_0_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null plk1 GeneRIF Biological Term Annotations 1.0 null PANC 02.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.842331 GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null eucatropine-4316 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Crus II, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.910132 H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SK-MES-1 GDSC Cell Line Gene Expression Profiles 1.0 1.62264 GSE157036,GSE166411_3_v_1_halofuginone_human RummaGEO Drug Perturbation Signatures 1.0 null Recruitment of NuMA to mitotic centrosomes Reactome Pathways 2024 1.0 null H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE261563_5_v_1_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null enalapril-7265 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6404-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null upper (rostral) rhombic lip_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.861606 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mitotic G2-G2/M phases Reactome Pathways 2024 1.0 null GSE125007,GSE125008_1_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE140322_3_v_2_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE185944_0_v_1_pth1r_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_A-366_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0180076 CRCGN014_HEPG2_24H:E19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.31863 Isolated growth hormone deficiency type IA DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.079 2313_DNM2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.544417 CRCGN015_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.16554 gentamicin-5883 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE186707_1_v_0_hdac4_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_Busulfan_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167045 POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.554318 GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles -1.0 -2.60808 GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles -1.0 -2.24657 f-9 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.988032 TCF7L2 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Vesicular gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.644 K562_Vandetanib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0211701 muscle GTEx Tissue Gene Expression Profiles -1.0 -2.10021 BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.779771 CRCGN011_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8625 H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-0006-SM-2I3FJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.867612 dilazep-7364 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-X4XX-0926-SM-46MV7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.936064 600MPE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.892507 GSE125782_0_v_1_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 outer dense fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.93274 GSE182680,GSE182683_7_v_9_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WHPG-2226-SM-3NMBO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893895 V, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.933722 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.81456 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2347 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.33328 arsenic trioxide_homo sapiens_gpl201_gse48441 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63W-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE186223,GSE186224_6_v_3_hmces_mouse RummaGEO Gene Perturbation Signatures 1.0 null K562_JQ1_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0230336 PMC11474056-pnas.2404841121.sd01.xlsx-Supplemental_Table_8_Fig1G-H-Supplemental_Table_8_Transcriptomic_overlap_between_LPS_and_Sepsis_and_or_Tuberculosis_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null PMC9314667-Table_1.xlsx-Regulons-ATF5_ATF5 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XBED-0003-SM-47JWP GTEx Tissue Sample Gene Expression Profiles 1.0 1.1061 Agranular insular area, dorsal part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57246 MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.05108 H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE147626_2_v_0_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03948 GSE234289_5_v_2_rfx6_human RummaGEO Gene Perturbation Signatures 1.0 null GSE215351,GSE215794_1_v_0_kdm8_mouse RummaGEO Gene Perturbation Signatures -1.0 null mebhydrolin-4795 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18784 GSE173232_1_v_3_sf3b1_human RummaGEO Gene Perturbation Signatures 1.0 null dorsal motor nucleus of the vagus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.07933 Lung squamous cell carcinoma_LUSC_TCGA-NK-A5D1-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE195582_0_v_1_pim1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE122215,GSE122217_0_v_4_peg10_mouse RummaGEO Gene Perturbation Signatures 1.0 null Spermatogenic failure 8 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.455 GSE202284,GSE202289_12_v_4_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CRCGN014_HEPG2_24H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.59455 NIPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11212 Retinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.242 Acute Myeloid Leukemia_LAML_TCGA-AB-2990-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Oligoasthenoteratozoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.511 PMC8724844-bt-30-1-98-supple2.xlsx-Hallmark_pathways-MXD1_MXD1 Rummagene Transcription Factor Associations 2026 1.0 null diphenhydramine-7318 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-1826-SM-2HMJE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965375 GSE223008_5_v_3_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null 10738_ZWINT_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.902617 ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.0435 H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CIAO2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.66045 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193993_0_v_7_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pelvis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.338914 hsa-miR-4719 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 4950_MED27_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.976329 GSE182680,GSE182683_5_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null pinacidil-7437 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K79me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XLM4-1526-SM-4AT6D GTEx Tissue Sample Gene Expression Profiles 1.0 2.2379 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FARAGE COSMIC Cell Line Gene Mutation Profiles 1.0 null Perinuclear region of cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.661 DB-56-XL71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.202097 superficial stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28767 MCF7_Rucaparib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0212625 A549_AICAR_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0196722 CRCGN016_MCF10A.TP53.M_24H:F10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.59146 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4723-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01197 PF-00539758-00-6379 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BC-56-CP81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.03072 H3K9ac_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Actomyosin contractile ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.725 GSE210101,GSE210114_5_v_10_urod_human RummaGEO Gene Perturbation Signatures 1.0 null PMC9314667-Table_1.xlsx-Regulons-FOSL1_FOSL1 Rummagene Transcription Factor Associations 2026 1.0 null GSE146074_9_v_3_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE202434,GSE202438_3_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-62-8399-01A-21R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null embryonic stem feeder layer BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 GTEX-NL3G-0008-SM-4E3JX GTEx Tissue Sample Gene Expression Profiles 1.0 0.981321 GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles 1.0 1.61357 Ciliary shaft COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.517 GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81545 GSE208171_0_v_1_zc4h2_human RummaGEO Gene Perturbation Signatures -1.0 null PIN1_DEPLETION_GDS4070_450_human_MDA-MB-231 breast cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CDK11A Pathway Commons Protein-Protein Interactions 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB ENCODE Transcription Factor Targets 1.0 null hsa-miR-3122 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.836145 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HT-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058161 Ansiform lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90788 POU4F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.7513 superficial stratum of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50305 deferoxamine-4317 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-OXRL-2126-SM-3NM98 GTEx Tissue Sample Gene Expression Profiles 1.0 2.13665 small GTPase binding GO Molecular Function Annotations 2025 1.0 null CRCGN016_MCF10A.TP53.M_24H:E14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.36507 GSE128232,GSE128233_1_v_0_phf2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Exocyst COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.433 H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null TA-57-FF07_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.344077 ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 1.09194 MCF7_Tozasertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0166831 abnormal glucose homeostasis GWASdb SNP-Phenotype Associations 1.0 0.204221 recruitment GeneRIF Biological Term Annotations 1.0 null NFYA ENCODE Transcription Factor Targets 1.0 null primary auditory cortex (core)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.68728 GTF2F1 ENCODE Transcription Factor Targets 1.0 null somatic Phosphosite Textmining Biological Term Annotations 1.0 null H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE250089_0_v_3_epcam_human RummaGEO Gene Perturbation Signatures 1.0 null cdk5 GeneRIF Biological Term Annotations 1.0 null HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.55817 odf2 GeneRIF Biological Term Annotations 1.0 null proper GeneRIF Biological Term Annotations 1.0 null mRNA_EP400_22196727 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-2W-A8YY-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5651844-41467_2017_1173_MOESM4_ESM.xlsx-sheet_1-Supplementary_Data_1_Down_regulated_genes_in_YEATS2_KD_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null MCF7_Tubastatin A HCl_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0136595 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null NH6 CCLE Cell Line Gene Expression Profiles -1.0 -1.49194 ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.833152 protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042487 CEP290 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50368 Edinger-Westphal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.52644 GATA5_KO_GDS4809_170_mouse_Lung GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44471 hsa-miR-1972 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE149901_2_v_1_anlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-POYW-0008-SM-48TE4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02417 primary GeneRIF Biological Term Annotations 1.0 null PMC12909836-44318_2025_675_MOESM6_ESM.xlsx-DA_E605_PerS1_M1_10_MQ-noMBR_MR-Unnamed_3_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-W5WG-0002-SM-3NMDN GTEx Tissue Sample Gene Expression Profiles 1.0 1.1379 OAW-28 GDSC Cell Line Gene Expression Profiles 1.0 1.5809 G120 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.858032 GSE181003_3_v_0_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null GSE111660_4_v_3_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null QB-69-QH67_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.29441 ELK1 ENCODE Transcription Factor Targets 1.0 null GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20287 mevalolactone-5738 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CEBPB_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null GSE100217_2_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null Ciliary base COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.947 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A6DV-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TEAD4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.1684 TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-5239-01A-21R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_CVGBM-gene_name_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null Lymphoblast TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.50387 CFPAC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48786 MCF7_BMS-754807_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0250563 whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00691 periventricular stratum of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.13914 Primary oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.777 CBX3 ENCODE Transcription Factor Targets 1.0 null GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02852 Protozoan form TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.588 eed_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.638052 dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40411 GSE226249_0_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null HCC2302 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.846409 GSE135514_2_v_7_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null regulation of cilium assembly GO Biological Process Annotations 2025 1.0 null H3K27me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE162739_6_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NUGC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34076 GTEX-Q2AI-1526-SM-3GIJ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.955881 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FRK MSigDB Cancer Gene Co-expression Modules 1.0 null MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.07819 hsa-miR-4476 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 Microtubule cytoskeleton COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.532 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Neural tube defect DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.408 MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RM2N-0006-SM-2TF5H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.850401 MCF7_GSK J1_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0205227 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10782 NCI-H1623 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5946-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE175571_3_v_2_acsl6_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MCF7_PHA-680632_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0139022 superficial stratum of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.84913 OC-314 COSMIC Cell Line Gene Mutation Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-3007-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Seckel syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.241 C21orf58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00436 GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles 1.0 1.0979 NCIH1915 CCLE Cell Line Gene CNV Profiles -1.0 -2.49533 GSE171837_0_v_3_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.045 19204204-SupplementaryTable3 GeneSigDB Published Gene Signatures 1.0 null GSE217452_3_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78877 cerebellar white matter Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51762 other GeneRIF Biological Term Annotations 1.0 null BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.949302 gonad TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 SR786 CCLE Cell Line Gene CNV Profiles -1.0 -1.92788 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XLM4-3126-SM-4AT6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.40662 Chromosome 13q14 deletion syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.547 Burkitt lymphoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.494 GSE206984_1_v_0_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null PSME4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19637 locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.38839 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-3126-SM-46MUB GTEx Tissue Sample Gene Expression Profiles 1.0 1.29374 VIIB, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.26395 GSE242083,GSE242098_2_v_4_med1_human RummaGEO Gene Perturbation Signatures 1.0 null flunisolide-3747 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NLS-Unnamed_1_ZNF385A Rummagene Transcription Factor Associations 2026 1.0 null methylphenidate_mus musculus_gpl11180_gse33619 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CEBPB_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Tie2 kinase inhibitor_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0110036 SKES1 CCLE Cell Line Gene Expression Profiles 1.0 1.48738 21NT DepMap CRISPR Gene Dependency 1.0 2.09731 hyoscyamine-5099 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE203308_6_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.63861 E2F4_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_0_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10592471-NIHMS1912771-supplement-7.xlsx-D-HEp3-Enh_vs_AA-up_genes-AA_up_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GSE218356_1_v_0_cited1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN012_HEPG2_24H:D08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.95399 Mitotic Prometaphase Reactome Pathways 2024 1.0 null ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAKI1 BioGPS Cell Line Gene Expression Profiles -1.0 -1.38371 dorsal peduncular cortex, periventricular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53492 NFATC1 ENCODE Transcription Factor Targets 1.0 null GSE225869_2_v_0_cd44_human RummaGEO Gene Perturbation Signatures 1.0 null CDC5L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.78937 CRCGN014_HEPG2_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.5093 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5149-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JURKAT, CLONE E6-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.0572 Sperm fibrous sheath COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.975 cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SIN3B ChEA Transcription Factor Targets 1.0 null sulfamonomethoxine-5843 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE216757_0_v_2_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null itself GeneRIF Biological Term Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Copula pyramidis, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45248 Azoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.585 flupentixol-1288 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NFIC JASPAR Predicted Transcription Factor Targets 1.0 null DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.006 MRTO4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0827 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04252 HEC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC10684125-cm9-136-2712-s001.xlsx-Sheet1-MXD1_MXD1 Rummagene Transcription Factor Associations 2026 1.0 null HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null ciliary part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Major island of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1034 GSE88819_5_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Crus 2, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90788 testis_7f HPA Tissue Sample Gene Expression Profiles 1.0 1.49345 BD-96-HO33_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.543633 CRCGN015_MCF10A_48H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1396 GTEX-RU72-0011-R11A-SM-2TF6J GTEx Tissue Sample Gene Expression Profiles 1.0 0.885559 H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE220058,GSE220059_0_v_1_prrc2b_human RummaGEO Gene Perturbation Signatures -1.0 null SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE108495_1_v_2_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null Cytoplasmic region COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.048 GSE112760,GSE112767_2_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NSMCE4A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45345 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.71974 intermediate stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2672 SP4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131649_2_v_11_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27me3_erythroblast_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1168 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null cytosol COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GSE178340_1_v_3_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E20-D3_1775_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE213588_9_v_5_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null Axonemal dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.583 sulfabenzamide-6634 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.144 PMC4944136-srep28995-s2.xls-NOBOX-gene_NOBOX Rummagene Transcription Factor Associations 2026 1.0 null GSE131649_2_v_5_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.87804 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BICR18 CCLE Cell Line Gene Expression Profiles 1.0 1.89772 testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.05457 H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null localization GeneRIF Biological Term Annotations 1.0 null phthalylsulfathiazole-3371 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cell property TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.310059 MCF7_Quisinostat_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00595804 MCF7_Barasertib_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0194896 TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TFE3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6724 Liver hepatocellular carcinoma_LIHC_TCGA-MI-A75C-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_EA_PCa-Unnamed_2_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null RAD21 ENCODE Transcription Factor Targets 1.0 null MCF7_PJ34_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0153467 Anchoring of the basal body to the plasma membrane Reactome Pathways 2024 1.0 null GSE205070_2_v_5_mertk_mouse RummaGEO Gene Perturbation Signatures 1.0 null embryonic structure TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060769 DND-41 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-4502 TargetScan Predicted Conserved microRNA Targets 1.0 0.517189 GSE93309_1_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCIH1395 CCLE Cell Line Gene Expression Profiles -1.0 -2.55537 GSE88819_11_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null diphemanil metilsulfate-4591 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE178340_5_v_9_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null SQLE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02354 IRF1 ENCODE Transcription Factor Targets 1.0 null GSE226249_0_v_4_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62707 GTEX-OIZG-0008-SM-4E3J2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11207 GSE142684_3_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE115363_2_v_4_esrrb_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTF2B ENCODE Transcription Factor Targets 1.0 null BE-27-RQ61_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.338622 GSE242367_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28178 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.38067 POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CLDN23 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50739 H3K9ac_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.719113 GSE117730,GSE117732_0_v_2_apobec2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NCIH1573 CCLE Cell Line Gene CNV Profiles -1.0 -1.376 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GEO COSMIC Cell Line Gene Mutation Profiles 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12774775-mmc2.xlsx-PAR_RARG_merge_q5_Narrow_subKO-ENSEMBL_ID_RARG Rummagene Transcription Factor Associations 2026 1.0 null NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.906751 intermediate stratum of Str Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24449 TMEM79 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05172 GSE191105_2_v_3_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null adiphenine-1831 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.64883 GSE210383_0_v_1_trim71_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE134615_1_v_0_lats1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-R55E-0726-SM-48FCZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.84642 oxolinic acid-2103 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RLF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32986 CRCGN008_HEPG2_24H:I01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.78445 CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213228_4_v_3_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null Flocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33995 CREBBP ENCODE Transcription Factor Targets 1.0 null PMC6053425-41467_2018_5258_MOESM20_ESM.xlsx-DREAM_MMBFoxM1_targets-Unnamed_1_KCNIP3 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.19391 variant GeneRIF Biological Term Annotations 1.0 null H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null fallopiantube_8c HPA Tissue Sample Gene Expression Profiles 1.0 1.07096 H3K4me1_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.91688 Perinuclear theca COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.011 CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null multicellular organismal development GO Biological Process Annotations 2015 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 16166618-SuppTable4 GeneSigDB Published Gene Signatures 1.0 null GSE188458_2_v_0_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures -1.0 null posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.877668 HMGN3 ENCODE Transcription Factor Targets 1.0 null GSE162739_8_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XPVG-2526-SM-4B66D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845214 AE-39-DG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.218077 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.61733 CTCF_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal male reproductive system physiology MPO Gene-Phenotype Associations 1.0 null estradiol_homo sapiens_gpl570_gse23610 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SKMEL24 CCLE Cell Line Gene CNV Profiles -1.0 -1.45682 mitosis GeneRIF Biological Term Annotations 1.0 null H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null HEY DepMap CRISPR Gene Dependency 1.0 3.01323 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.86027 Hs-578-T GDSC Cell Line Gene Expression Profiles -1.0 -2.98765 MCF7_CEP-33779_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147498 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_FLLL32_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179103 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null procyclidine-2991 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SPI1 ChEA Transcription Factor Targets 1.0 null Fatty Liver CTD Gene-Disease Associations 1.0 1.47322 Rectum adenocarcinoma_READ_TCGA-DY-A1DE-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.695724 Prestwick-691-4092 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0353 GSE126463_6_v_3_pomalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null IV Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.90269 Motor nucleus of trigeminal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17006 oligomycin-442 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null VIIIA, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.23033 K562_MK-5108_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0201018 STAT4 MotifMap Predicted Transcription Factor Targets 1.0 null Spi1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 703.382 Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A3ZF-01A-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE125862_2_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null BC-25-VR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.758024 CRCGN015_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.3042 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TSE9-2626-SM-4DXV2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.899452 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.907674 cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.06464 CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A76B-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PVOW-2726-SM-48TCA GTEx Tissue Sample Gene Expression Profiles 1.0 1.33235 GSE131887_5_v_2_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE225735_0_v_4_aldosterone_human RummaGEO Drug Perturbation Signatures 1.0 null ampicillin-1530 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null Osteoarthritis_Chondrocyte_GSE16464 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.46725 Katanin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.6 PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null germ cell development GO Biological Process Annotations 2015 1.0 null KLM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00984 GSE236228_0_v_1_penfluridol_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02474 Septin ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.638 colon TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.066294 GSE58724_3_v_4_oxymetholone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Uvula (IX) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30834 hsa-miR-1236 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Ciliary plasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.423 H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null K562_WHI-P154_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0217376 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Spz1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.5833 MCF7_Decitabine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0122255 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15367 KDM5B ChEA Transcription Factor Targets 1.0 null MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBE3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28474 VI, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.93239 K562_Valproic acid sodium salt_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0187694 SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09778 Brain Lower Grade Glioma_LGG_TCGA-DU-6406-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null sequences GeneRIF Biological Term Annotations 1.0 null 16715129-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null CRCGN015_MCF10A_48H:F06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.16365 GTEX-WZTO-0011-R11A-SM-4E3K9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11181 GSE152441,GSE152442_6_v_5_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Erythroleukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MDA-MB-157 COSMIC Cell Line Gene Mutation Profiles 1.0 null Trachomatis DisGeNET Gene-Disease Associations 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null YD38 CCLE Cell Line Gene CNV Profiles 1.0 1.74697 mimosine-2638 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Islands of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.90965 abnormal male germ cell morphology MPO Gene-Phenotype Associations 1.0 null Aorta Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.4575 MITF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.3078 GSE158969_1_v_0_trastuzumab_human RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A4ZV-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-2026-SM-4E3KA GTEx Tissue Sample Gene Expression Profiles 1.0 1.81287 K562_Curcumin_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159076 Hemispheric regions Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79407 Pancreatic adenocarcinoma_PAAD_TCGA-US-A776-01A-13R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16632 CAL 27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0393 GSE110708_1_v_3_adar_mouse RummaGEO Gene Perturbation Signatures -1.0 null Eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.189 K562_GSK-LSD1 2HCl_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0170254 isthmic alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38094 pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.890575 trichostatin A-2375 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE225684_0_v_2_tfap4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null ventrolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16338 HA7-RCC COSMIC Cell Line Gene Mutation Profiles 1.0 null cerebellar cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05798 BICR22 CCLE Cell Line Gene CNV Profiles 1.0 1.57961 ELK1::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4746 Entorhinal area, medial part, ventral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04904 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 mitotic cell cycle GO Biological Process Annotations 2015 1.0 null Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.725 H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE220942_2_v_1_galnt7_human RummaGEO Gene Perturbation Signatures 1.0 null GSE110178_4_v_0_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE131649_6_v_11_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 tail of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.824081 POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE212486,GSE212488_2_v_3_gata4_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_GSK1070916_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0138261 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Vortioxetine_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0203869 PMC12700831-41594_2025_1680_MOESM4_ESM.xlsx-D9_EC_Hits_2_5FC_Filtered_Out-Mapped_Gene_Symbol_CENPX Rummagene Transcription Factor Associations 2026 1.0 null cytoplasmic microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.136856 GSE156708_1_v_2_fbxo11_human RummaGEO Gene Perturbation Signatures 1.0 null abnormal sperm motility MPO Gene-Phenotype Associations 1.0 null New mitotic spindle pole body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.951 GSE242083,GSE242098_2_v_1_med1_human RummaGEO Gene Perturbation Signatures 1.0 null G142 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.451 VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.51176 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T8-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XYKS-0002-SM-4BRWN GTEx Tissue Sample Gene Expression Profiles 1.0 1.10707 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE220806_1_v_3_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null SP in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.898817 GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31369 H3K4me1_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null LXF-289 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.995366 macromolecular complex GO Cellular Component Annotations 2015 1.0 null NCI-H1563 GDSC Cell Line Gene Expression Profiles -1.0 -1.93292 GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93103 FD-62-ZB67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.351417 tonsil_8a1 HPA Tissue Sample Gene Expression Profiles 1.0 0.893173 Kinocilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.122 MHHCALL3 CCLE Cell Line Gene Expression Profiles 1.0 2.56759 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE102870_11_v_0_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null JUN_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_1_RFX1 Rummagene Transcription Factor Associations 2026 1.0 null Organelle biogenesis and maintenance Reactome Pathways 2014 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3467-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uropygial gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.871 CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null manchette COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.504318 physostigmine-2768 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.064 lateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15829 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.9482 preweaning lethality MPO Gene-Phenotype Associations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-FC-A4JI-01A-11R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RKO-E6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15525 NCAPG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00366 Prostatic Diseases CTD Gene-Disease Associations 1.0 1.02447 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sperm flagellum COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.732677 H3K4me3_Penis Foreskin Keratinocyte Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RAB3A_KO_GDS2483_700_mouse_Cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null plagl2_17983586_small_intestine_lof_mouse_gpl1261_gds3010 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.106696 mantle zone of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.13511 Lingula (I), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0736 GTEX-N7MS-0426-SM-2YUN6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35447 JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE241701_4_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZBTB12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.9102 NPIPA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35982 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLI3 MotifMap Predicted Transcription Factor Targets 1.0 null spina bifida DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.712796 Acute Myeloid Leukemia_LAML_TCGA-AB-2834-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Varicocele DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.045 GSE239651_1_v_0_ispinesib_human RummaGEO Drug Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.42166 Seminiferous tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.651 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-26b-5p MiRTarBase microRNA Targets 1.0 null sense organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068437 MYC ENCODE Transcription Factor Targets 1.0 null Frontal pole, cerebral cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00274 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE242647_2_v_3_adiponectin_mouse RummaGEO Drug Perturbation Signatures -1.0 null DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.332782 FBXO25 Pathway Commons Protein-Protein Interactions 1.0 null PBX3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-652-ENSG00000196152_ZNF79 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-VUSG-1726-SM-4KKZL GTEx Tissue Sample Gene Expression Profiles 1.0 0.945111 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.75731 P30-OHK COSMIC Cell Line Gene Mutation Profiles 1.0 null superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.64621 Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCL6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.5434 NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1143 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.91052 SK-MEL-31 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.77626 REC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.39164 CREB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r7 part of the posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28823 GTEX-PVOW-2626-SM-32PL8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28103 azapropazone-7277 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE134375_6_v_2_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null pimozide-7132 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Outer dense fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.898 A549_BRD4770_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0225394 H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.235883 16293578-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null IGR-37 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null embryonic carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.797708 GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83273 Retinitis pigmentosa 54 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.103 immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040731 cell part GO Cellular Component Annotations 2015 1.0 null MIA PACA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.46322 GSE218879_1_v_0_acetaminophen_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE88819_3_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-UJMC-0008-SM-4IHKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.2682 Agranular insular area, ventral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45222 GSE185944_2_v_1_pth1r_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_10_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.13049 GSE131377_1_v_3_spocd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null mortality/aging MPO Gene-Phenotype Associations 1.0 null spiradoline-4553 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS11 DepMap CRISPR Gene Dependency 1.0 3.5834 CTCF_cerebellum_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CNS cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.855 ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26527 GTEX-Q2AG-3026-SM-48U1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.37429 Pancreatic adenocarcinoma_PAAD_TCGA-XN-A8T3-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-N7MS-0008-SM-4E3JI GTEx Tissue Sample Gene Expression Profiles 1.0 0.952819 guanabenz-2045 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null K562_S-Ruxolitinib_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0262487 TAF1_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdalohippocampal transition zone, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.52919 NCI-H1693 COSMIC Cell Line Gene Mutation Profiles 1.0 null FC-13-VS25_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.734326 Acute Myeloid Leukemia_LAML_TCGA-AB-2862-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acrosomal vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.029 Piriform-amygdalar area, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00349 ZDHHC17 Pathway Commons Protein-Protein Interactions 1.0 null K562_PCI-34051_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0209378 GSE199255,GSE199356_4_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null fallopian tube HPA Tissue Protein Expression Profiles 1.0 1.3096 primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.29291 GTEX-TSE9-0011-R11A-SM-3DB7N GTEx Tissue Sample Gene Expression Profiles 1.0 0.984912 POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null splice Phosphosite Textmining Biological Term Annotations 1.0 null intermediate stratum of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.43364 tetrahydroalstonine-6209 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CREBBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.38815 POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U8T8-1126-SM-4DXUE GTEx Tissue Sample Gene Expression Profiles 1.0 2.20884 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.7581 Prestwick-665-3681 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null peripheral nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.107846 GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62784 GSE115542_2_v_1_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45548 GSE228181_4_v_1_idh1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24524 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cauda epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.593 SRY-25088423-EMBRYONIC GONADS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Microtubule bundle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.008 GSE214931_2_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE225869_2_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null K562_SL-327_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144059 GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27729 L428 CCLE Cell Line Gene Expression Profiles 1.0 3.02449 caudal prosubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.93338 IRF3 ENCODE Transcription Factor Targets 1.0 null H3K79me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE146612_2_v_0_amiodarone_human RummaGEO Drug Perturbation Signatures -1.0 null K562_Obatoclax Mesylate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154297 membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null GSE133087_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null USF1_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPD_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-525-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 PMC5047620__F6 PFOCR Pathway Figure Associations 2023 1.0 null MCF7_Navitoclax_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137303 striatum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.98814 YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE126345_9_v_10_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null cleavage furrow COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.233101 Dorsal peduncular area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10685 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UTHO-3126-SM-3P5ZB GTEx Tissue Sample Gene Expression Profiles 1.0 1.47177 GTEX-XQ3S-0001-SM-4B64K GTEx Tissue Sample Gene Expression Profiles 1.0 0.910409 CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Loss of Nlp from mitotic centrosomes Reactome Pathways 2014 1.0 null outer CP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.21344 H4K5ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null promazine-3833 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XPT6-2026-SM-4B64V GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841073 anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.45719 sulfadimidine-3765 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Spindle midzone COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.205 A549_Pracinostat_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00908568 GATA2-21666600-HMVEC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null cellular developmental process GO Biological Process Annotations 2015 1.0 null abnormal sperm axoneme morphology MGI Mouse Phenotype Associations 2023 1.0 null PMC5997284-NIHMS973253-supplement-4.xlsx-Sheet1-MMB_FOXM1_Targets_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null Lobule II, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35877 GSPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22108 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13772 ELF5-23300383-T47D-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ciliary transition zone COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.532 ZNF667 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.0721 KE39 CCLE Cell Line Gene CNV Profiles 1.0 1.37496 GSE102870_3_v_0_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null FOSB::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4342 autonomic nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.15295 GSE161800_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OIZH-2026-SM-3NB1M GTEx Tissue Sample Gene Expression Profiles 1.0 0.93712 Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 859_BMS1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.667555 CREM ChEA Transcription Factor Targets 1.0 null A549_Costunolide_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0156089 GB-84-KP45_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.229269 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4974-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE125014_1_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T2IS-2926-SM-32QPO GTEx Tissue Sample Gene Expression Profiles 1.0 1.08262 preoptic region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02733 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r3Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0627 eGFP-HDAC8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PA-75-VL17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.795901 GTEX-WFG8-0001-SM-4LVN8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01069 striatal part of olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73288 GSE120413,GSE120447_0_v_5_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Cell Transformation, Neoplastic CTD Gene-Disease Associations 1.0 1.24024 GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23667 terguride-6459 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null nuclear part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044621 496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.18319 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null multiform (lateral) division of MD Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04358 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4F9-06A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A700-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCL-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE228106_0_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null phenacetin-2471 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE128730_7_v_5_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ventrolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02172 VIIIA, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.16453 pivmecillinam-7312 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CHD7 ENCODE Transcription Factor Targets 1.0 null intermediate stratum of SePal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39523 valinomycin-5911 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE209533_0_v_1_disulfiram_human RummaGEO Drug Perturbation Signatures -1.0 null AB-30-CR11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.260547 Tobacco Use Disorder HuGE Navigator Gene-Phenotype Associations 1.0 null GSE193177_1_v_2_st266_mouse RummaGEO Drug Perturbation Signatures -1.0 null gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.02381 Brain Lower Grade Glioma_LGG_TCGA-KT-A7W1-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PW2O-1726-SM-2S1OO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02981 SREBF1 JASPAR Predicted Transcription Factor Targets 1.0 null cochlear duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.252261 prochlorperazine-455 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cytoskeletal part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE121319_1_v_0_gprc5a_human RummaGEO Gene Perturbation Signatures 1.0 null nomifensine-2062 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K79me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A549_Regorafenib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0170887 GSE186005_1_v_2_klf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100332_HIP_possible Alzheimer's disease_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.75789 MAJIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02897 DYNLRB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76234 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EE-98-PF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.23137 Inner acrosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.334 BEND6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01058 Leukocyte TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE154577_6_v_10_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null N6-methyladenosine-1271 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE131649_6_v_7_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null axoneme part GO Cellular Component Annotations 2015 1.0 null SRF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null valproic acid-1078 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE178340_7_v_9_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.4306 MCF7_Ellagic acid_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0182474 Central lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40716 GSE184087_4_v_3_tert_human RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Carmofur_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0165129 SON_KD_GDS4448_35_human_HeLa GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.5671 nucleus LOCATE Predicted Protein Localization Annotations 1.0 null basolateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.25742 JHOS4 CCLE Cell Line Gene Expression Profiles -1.0 -1.56175 GSE160817_5_v_1_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null single-organism process GO Biological Process Annotations 2015 1.0 null GSE247862,GSE247863_0_v_5_eomes_mouse RummaGEO Gene Perturbation Signatures -1.0 null Axonemal outer doublet COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.052 GSE211215_1_v_0_akr1b1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE189683_3_v_0_rif1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PDK1_knockout_80_GSE26290 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.08143 Prostate adenocarcinoma_PRAD_TCGA-YL-A8HL-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.12286 GSE233049_1_v_0_atf3_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88507 Lung squamous cell carcinoma_LUSC_TCGA-66-2786-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Iniparib_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0246948 periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.919837 PMC8143797-elife-62857-fig3-data2.xlsx-DEgenes_SW872_TAZ-CAMTA1_vs_EV-Gene_CAMTA1 Rummagene Transcription Factor Associations 2026 1.0 null H4K20me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null metyrapone-3070 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null trichoplein GeneRIF Biological Term Annotations 1.0 null EIF2B5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27937 CRCGN008_HEPG2_24H:B24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.4689 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4696-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE115363_2_v_0_esrrb_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_SL-327_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146734 SIRT1_KO_GDS3666_295_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null ZBTB7A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null aminoglutethimide-7463 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE88819_1_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.986823 PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MLX_TESTES_MLX Rummagene Transcription Factor Associations 2026 1.0 null GTEX-NPJ7-0011-R11A-SM-2I3E8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10251 K562_Mesna_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0147939 496100315_TCx_no dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.47578 CRCGN014_HEPG2_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.22712 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-S341-1326-SM-4AD72 GTEx Tissue Sample Gene Expression Profiles 1.0 0.877971 raphe magnus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.857901 RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZI-0126-SM-3NB13 GTEx Tissue Sample Gene Expression Profiles 1.0 1.5977 PD-70-VS77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.339296 GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47586 abnormal survival MPO Gene-Phenotype Associations 1.0 null H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ1-0003-SM-3NMAE GTEx Tissue Sample Gene Expression Profiles 1.0 0.954529 CRCGN016_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.69834 K562_BMS-536924_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0256296 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_GSK J1_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0171888 Vein disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.514 Secondary oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.793 GSE246660_1_v_0_glycerol_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-U3ZH-1526-SM-4DXV1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.51006 Sendai virus infection_Tracheal epithelium_GSE10211 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.31698 SC-58125-208 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null FOXF2 JASPAR Predicted Transcription Factor Targets 1.0 null CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.62652 GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.462 Paramedian lobule, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.0644 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r4 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02724 GSE239688_2_v_3_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 54.4526 GSE102675_3_v_0_atf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE226249_0_v_1_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null LRRK1 Pathway Commons Protein-Protein Interactions 1.0 null PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_8-ILL1_T_Cells_FOXP3_FOXP3 Rummagene Transcription Factor Associations 2026 1.0 null amitriptyline-1823 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GR-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.78212 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null dorsolateral part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10436 GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09434 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_10_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.910298 GTEX-XUJ4-0004-SM-4BOQE GTEx Tissue Sample Gene Expression Profiles 1.0 1.24638 PMC3573729-nl3042917_si_005.xlsx-OWY_Overlap_with_ANOVA-ORKIN_MAX_MAX Rummagene Transcription Factor Associations 2026 1.0 null AURKA Pathway Commons Protein-Protein Interactions 1.0 null periventricular stratum of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37389 ETS1 ENCODE Transcription Factor Targets 1.0 null K562_FLLL32_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0204446 CHCHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.72277 CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEC-0126-SM-4GIDT GTEx Tissue Sample Gene Expression Profiles 1.0 2.13393 GSE235945_1_v_0_pikfyve_mouse RummaGEO Gene Perturbation Signatures -1.0 null fibers Phosphosite Textmining Biological Term Annotations 1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SNOS-1126-SM-4DM67 GTEx Tissue Sample Gene Expression Profiles 1.0 2.2781 H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CRCGN013_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2535 macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042131 GSE158632_3_v_1_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null HB-06-WU12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.241589 GTEX-OIZI-0626-SM-2XCEH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.9399 simvastatin-4244 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.62308 dorsolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.91971 H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null transmission ratio distortion MPO Gene-Phenotype Associations 1.0 null USF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-7667-01A-31R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null CREB1-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q734-2026-SM-3GADA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0545 skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles -1.0 -1.4106 Fibrillary inclusion COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.589 AC-76-JB92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.905846 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P78B-2526-SM-3P5ZY GTEx Tissue Sample Gene Expression Profiles 1.0 0.878121 ninein GeneRIF Biological Term Annotations 1.0 null GSE225869_1_v_0_cd44_human RummaGEO Gene Perturbation Signatures 1.0 null SIN3A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZM-1626-SM-4DXSK GTEx Tissue Sample Gene Expression Profiles 1.0 1.5991 GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07256 Simple lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.98875 cytosol GO Cellular Component Annotations 2015 1.0 null Micronuclei, Chromosome-Defective CTD Gene-Disease Associations 1.0 1.09857 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Colorectaladenocarcinoma BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.870112 tanespimycin-1650 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DAN-G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31384 STAT3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.2713 reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.04319 hindbrain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21513 GSE244710_1_v_2_srsf1_human RummaGEO Gene Perturbation Signatures -1.0 null NFIC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.0391 Uvula (IX), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36943 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null GSE146612_2_v_3_amiodarone_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 2731_ESF1_P1 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.545334 irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.171226 GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.59652 Crus 1, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90788 intermediate stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08705 GTEX-NL4W-0008-SM-4E3I2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.905986 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.980324 PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_down-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.045001 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.925536 Lung adenocarcinoma_LUAD_TCGA-91-6835-11A-01R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HEC6 DepMap CRISPR Gene Dependency 1.0 3.98608 Copula pyramidis, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61373 HCC1599 CCLE Cell Line Gene CNV Profiles 1.0 1.40294 GSE162590_1_v_0_gsx2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE223893_1_v_9_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null BD-29-IQ20_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230466 methazolamide-5794 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ELK4_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 16651409-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null UBC Pathway Commons Protein-Protein Interactions 1.0 null KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.42152 CRCGN008_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0241 GTEX-XMK1-2026-SM-4B65K GTEx Tissue Sample Gene Expression Profiles 1.0 1.62408 TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal fertility/fecundity MPO Gene-Phenotype Associations 1.0 null GTEX-TSE9-2926-SM-3DB77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1228 YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCC2998 DepMap CRISPR Gene Dependency 1.0 4.75285 GTEX-U8XE-2526-SM-4E3IT GTEx Tissue Sample Gene Expression Profiles 1.0 1.01336 GSE118766_2_v_3_ifng_mouse RummaGEO Gene Perturbation Signatures 1.0 null Latex allergy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.123 PRDM5 ChEA Transcription Factor Targets 1.0 null 20min_EGF vs ctrl_HeLa (Human) [17081983] SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands 1.0 null GTEX-WFON-2026-SM-4LVMW GTEx Tissue Sample Gene Expression Profiles 1.0 1.49114 IZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1041 FAN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32184 Brain Lower Grade Glioma_LGG_TCGA-DU-A7TJ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:O13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.59288 PF382 CCLE Cell Line Gene Expression Profiles 1.0 1.47742 ELK1 ChEA Transcription Factor Targets 1.0 null layer II of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.43743 Lung squamous cell carcinoma_LUSC_TCGA-85-7950-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null F-9 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.75 amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.58048 SNU-C5 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE135030_8_v_5_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NFYA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Lenalidomide_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0228391 MYOG ENCODE Transcription Factor Targets 1.0 null PKNOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7016 seminiferous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.468048 CEBPB_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CE-96-GH46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.243592 laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.97702 GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.12921 CORL24 CCLE Cell Line Gene CNV Profiles -1.0 -1.46319 K562_AICAR_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0173314 GTEX-QESD-2026-SM-447BI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29109 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BE-79-QU25_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.368415 Cell division site COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.443 Brain Lower Grade Glioma_LGG_TCGA-S9-A7J0-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SARS-CoV MA15_Day7-C57BL6_None_GSE51386 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.58396 GSE202434,GSE202438_10_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null embryonic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.373493 GSE110268_2_v_3_foxd1_human RummaGEO Gene Perturbation Signatures -1.0 null sympathetic ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.371245 GSE203181_0_v_1_phosphoramidon_human RummaGEO Drug Perturbation Signatures 1.0 null lateral nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.925849 Phragmoplast COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.625 GSE224311_3_v_1_chaetocin_human RummaGEO Drug Perturbation Signatures 1.0 null NCIH2030 CCLE Cell Line Gene CNV Profiles -1.0 -1.69351 MLF1 MSigDB Cancer Gene Co-expression Modules 1.0 null GTEX-NL3H-0011-R7a-SM-2I3G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.966084 GSE239844_4_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null mitotic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.354455 GSE151494_1_v_3_nrp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null FOXM1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF384_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKRC31 CCLE Cell Line Gene CNV Profiles -1.0 -1.62242 K562_PD98059_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167121 Spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.498 testis_4a HPA Tissue Sample Gene Expression Profiles 1.0 1.1851 GSE146074_10_v_8_ly6e_mouse RummaGEO Gene Perturbation Signatures -1.0 null FAHD2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08206 dydrogesterone-2156 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null Kidney Neoplasms CTD Gene-Disease Associations 1.0 1.22632 sirolimus_homo sapiens_gpl2895_gse16944 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hematopoietic cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.31263 outer dense fiber COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 SMARCB1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A172 DepMap CRISPR Gene Dependency 1.0 8.77467 SIN3A-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5KY-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate part of StrSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15525 GSE239844_8_v_10_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE179868,GSE180330_1_v_0_ddx21_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRL-1626-SM-2YUMU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.952981 STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-1626-SM-4AD6G GTEx Tissue Sample Gene Expression Profiles 1.0 0.890301 striatum_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.968699 GTEX-OHPM-2126-SM-3LK75 GTEx Tissue Sample Gene Expression Profiles 1.0 1.88849 GSE193177_1_v_3_st266_mouse RummaGEO Drug Perturbation Signatures -1.0 null Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 IRF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9316731-13059_2022_2728_MOESM2_ESM.xlsx-S3_AlternativeTSS_ZF-D3A-wt-Gene_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null E2F4_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null K562_BMS-754807_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0240369 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.406361 K562_Tacedinaline_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159226 inner CP in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.97067 H3K9ac_Peripheral Blood Mononuclear Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NM-01A-21R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null accumbens nucleus, core domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.14324 19061838-TableS7 GeneSigDB Published Gene Signatures 1.0 null GTEX-QEL4-0626-SM-3GIJM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36759 gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055398 VMRCLCP CCLE Cell Line Gene CNV Profiles -1.0 -1.54885 NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP in rostral midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.08858 C2BBE1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.865824 GSE225141,GSE225143_2_v_3_mettl3_mouse RummaGEO Gene Perturbation Signatures -1.0 null RAD21_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_BRD4770_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0175462 CRCGN008_HEPG2_24H:I06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1826 GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27763 GSE233679_12_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE178340_7_v_6_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A1H5-01A-31R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE218727_2_v_1_zkscan3_human RummaGEO Gene Perturbation Signatures 1.0 null ZBTB7A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC52A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.367 PLCB2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07737 POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null C-75-6423 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NDUFA6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.16033 GTF2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAD cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.932 medial habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02334 Secretory granule membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.354 GSE210476_2_v_6_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null MCF7_Prednisone_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145256 cell surface furrow COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.233101 SPI1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3662 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 CRCGN017_MCF10A.TP53.M_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.66193 Polycystin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.761 CRCGN015_MCF10A_48H:K22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21993 FA-92-JL46_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.247632 mediates GeneRIF Biological Term Annotations 1.0 null E2F6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null substantianigra BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.48723 GSE198165,GSE198166_9_v_4_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null RASSF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1136 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null OTX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.7257 GSE198165,GSE198166_0_v_1_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE205163,GSE205164_3_v_6_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null GSE123958,GSE123959_0_v_1_mta1_human RummaGEO Gene Perturbation Signatures 1.0 null Sperm plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.411 GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38205 PANC0327 DepMap CRISPR Gene Dependency 1.0 5.50957 GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.966028 GSE242647_2_v_0_adiponectin_mouse RummaGEO Drug Perturbation Signatures -1.0 null clebopride-1292 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI H226 BioGPS Cell Line Gene Expression Profiles -1.0 -1.07746 THAP1 ENCODE Transcription Factor Targets 1.0 null GSE202434,GSE202438_6_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.0911 GSE198165,GSE198166_7_v_4_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XBEW-0006-SM-4AT4E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.878708 Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null beta-escin-2194 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null internal male genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 MCF7_Fluorouracil_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0111527 GSE236003_2_v_3_ubr5_human RummaGEO Gene Perturbation Signatures 1.0 null paromomycin-4595 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE103068_0_v_1_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null male infertility MPO Gene-Phenotype Associations 1.0 null MYOG_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE68155_3_v_2_gpr3_mouse RummaGEO Gene Perturbation Signatures 1.0 null DB-56-XL71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.218701 GTEX-WH7G-1926-SM-4LVMM GTEx Tissue Sample Gene Expression Profiles 1.0 1.77645 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.972473 MCF7_Ofloxacin_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0114131 LOX IMVI BioGPS Cell Line Gene Expression Profiles 1.0 1.45247 H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.41221 raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.53169 GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.990752 H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null A549_BMS-265246_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0111291 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7409-01A-31R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE239844_7_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null paraseptal subpallium Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32623 female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 MCF7_Alendronate sodium trihydrate_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0182152 Striatum ventral region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.83884 GSE235701,GSE261434_0_v_3_enasidenib_human RummaGEO Drug Perturbation Signatures 1.0 null NR1D2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3169 Folium-tuber vermis (VII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.24127 structural molecule activity GO Molecular Function Annotations 2015 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A97K-01A-21R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.612958 POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TP53 JASPAR Predicted Transcription Factor Targets 1.0 null GSE124410_2_v_5_stk40_mouse RummaGEO Gene Perturbation Signatures -1.0 null nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.008036 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A41B-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null vestibular labyrinth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.170443 4578_LIG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.931847 PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-DREAM_target_genes_KCNIP3 Rummagene Transcription Factor Associations 2026 1.0 null GSE210682_2_v_3_methadone_human RummaGEO Drug Perturbation Signatures -1.0 null GSE198165,GSE198166_5_v_11_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null Crus 1, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92037 microtubule organizing center GO Cellular Component Annotations 2015 1.0 null HCC1493 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09846 HOXA5 JASPAR Predicted Transcription Factor Targets 1.0 null head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-RTLS-0526-SM-2TF64 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.909552 GSE240027,GSE240030_1_v_4_atrx_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2032 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CEBPD ENCODE Transcription Factor Targets 1.0 null SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.46367 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.576415 hypersensitivity reaction type i disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.207912 CRCGN016_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.27101 GTEX-Q2AG-0011-R11A-SM-2HMKZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.978195 primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05045 TF1 CCLE Cell Line Gene Expression Profiles 1.0 1.56658 GSE111247_11_v_3_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null Simple lobule, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.9469 posteroventral (inferior) parietal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.34723 GTEX-T6MN-2526-SM-32PMN GTEx Tissue Sample Gene Expression Profiles 1.0 1.31547 GSE150215_1_v_2_etl4_mouse RummaGEO Gene Perturbation Signatures -1.0 null 496100665_PCx_probable Alzheimer's disease_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.12008 PMC8497824-Table_4.xlsx-Stage_4_EOMES_vs_Ctrl-Unnamed_1_EOMES Rummagene Transcription Factor Associations 2026 1.0 null NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.976961 PMC3470785-NIHMS377161-supplement-3.pdf-216-ZFP64_ZFP64 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-V1-A8WV-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07871 5205_MRPL21_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.896241 POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1-22589737-MCF10A-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.72337 cell division site part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.108637 GSE111247_0_v_13_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null cortex of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50305 GSE191105_2_v_4_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SNU1076 CCLE Cell Line Gene CNV Profiles 1.0 2.19038 CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null OMC-1 GDSC Cell Line Gene Expression Profiles 1.0 2.44746 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC3573729-nl3042917_si_005.xlsx-OWY_Overlap_with_ANOVA-ORKIN_CTCF_CTCF Rummagene Transcription Factor Associations 2026 1.0 null Prostate adenocarcinoma_PRAD_TCGA-XJ-A83F-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE190235_1_v_2_foxo3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE88819_0_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null cellular process GO Biological Process Annotations 2015 1.0 null hsa-miR-4756-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 HS 255.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.5126 GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08828 GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20359 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.896006 phenelzine-4538 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Ciliary tip COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.483 PMC6995218-12864_2020_6525_MOESM3_ESM.xlsx-D2FAST48h_vs_D3REFED24h_1198_AR-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles 1.0 1.11591 voltage-gated calcium channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.99 withaferin A-3819 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Lung adenocarcinoma_LUAD_TCGA-64-1676-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null transmission ratio distortion MGI Mouse Phenotype Associations 2023 1.0 null GTEX-PSDG-0008-SM-48TE5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16298 DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.25902 GTEX-N7MS-0126-SM-3TW8O GTEx Tissue Sample Gene Expression Profiles 1.0 3.09946 COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06307 GSE163809_1_v_2_sdhaf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null K562_Roscovitine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.017 GSE224311_3_v_4_chaetocin_human RummaGEO Drug Perturbation Signatures 1.0 null tubulin Phosphosite Textmining Biological Term Annotations 1.0 null Voriconazole_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00929904 PMC5159535-supp_gkw757_nar-00810-met-z-2016-File016.xlsx-S9_SOM-Unnamed_3_GRHL3 Rummagene Transcription Factor Associations 2026 1.0 null abnormal sperm physiology MPO Gene-Phenotype Associations 1.0 null Asphyxiating thoracic dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.058 Dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.889 hexestrol-5776 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null chlorprothixene-1272 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.16522 GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1989 idoxuridine-4785 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RINT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10679 Testicular cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.146 primary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.637594 genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.043387 TBC1D2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32677 A704 CCLE Cell Line Gene Expression Profiles -1.0 -2.21126 USF2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF3 ENCODE Transcription Factor Targets 1.0 null leukocyte TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR4A2::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6008 HPAF-II Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.988673 Cortical granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.622 PMC9753996-jci-132-160767-s182.xlsx-IRF4_assciated-ABCA7_IRF4 Rummagene Transcription Factor Associations 2026 1.0 null centrosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.29371 CRCGN016_MCF10A.WT.HP_24H:A09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0135 (+)-chelidonine-5760 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null nucleus sagulum, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23143 orlistat-6388 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.225399 dizocilpine-2069 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-U4B1-1626-SM-3DB8N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.83096 GSE110248_1_v_6_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null testis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 GTEX-WCDI-0005-SM-3NB2M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.891606 prostate cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.124377 renal tubular transport disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.523816 RKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15525 hsa-miR-3148 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 MAFG::NFE2L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3066 MCF7_Curcumin_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171474 15-delta prostaglandin J2-4455 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE131649_2_v_0_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null Lymphoid cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-QLQ7-1726-SM-2S1QQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13588 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.552 OC-10-FB51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.721118 valproic acid-6941 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PPARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.2143 CRCGN013_HEPG2_24H:B07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.43986 MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.895292 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Alisertib_10µM_72h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149743 CRCGN011_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.284 internal granular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.84913 CPT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09293 salbutamol-2344 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-FB-A5VM-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MEL cell line_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRY ChEA Transcription Factor Targets 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null PMC6985208__F2 PFOCR Pathway Figure Associations 2023 1.0 null GSE132369,GSE132371_4_v_0_cccp_human RummaGEO Drug Perturbation Signatures -1.0 null Amylin receptor complex 1 COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.573 amiprilose-4000 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null VI, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.23053 orbital frontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.18988 H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null HEB MotifMap Predicted Transcription Factor Targets 1.0 null Neurosphere_Cultured_Cells_Cortex_Derived Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.914937 GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -2.171 Lobule II, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2705 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null imatinib_homo sapiens_gpl96_gds3045 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null K562_Motesanib Diphosphate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161577 lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.01563 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRN-2626-SM-48TBX GTEx Tissue Sample Gene Expression Profiles 1.0 1.43331 primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.895386 metamizole sodium-3754 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04116 GSE193177_1_v_0_st266_mouse RummaGEO Drug Perturbation Signatures -1.0 null probenecid-4185 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.421604 Kidney Chromophobe_KICH_TCGA-KN-8429-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.951714 lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24757 hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.846476 K562_TMP195_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0271155 K562_UNC0631_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0160702 GTEX-R55E-2526-SM-2TC6H GTEx Tissue Sample Gene Expression Profiles 1.0 1.02633 centrosome Phosphosite Textmining Biological Term Annotations 1.0 null male infertility MGI Mouse Phenotype Associations 2023 1.0 null PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Up_HES4 Rummagene Transcription Factor Associations 2026 1.0 null dexpropranolol-5814 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE137325_3_v_0_copanlisib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE126345_11_v_10_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null estradiol-121 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null EC-62-OE64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.469174 SINHCAF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07197 GSE127916_1_v_4_nras_human RummaGEO Gene Perturbation Signatures -1.0 null PMC8160578-JCB_202009147_TableS4.xlsx-FOXM1_targets-Genes_n_696_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.06165 YTHDF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19546 GSE189683_1_v_2_rif1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Leber congenital amaurosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.055 PMC8175556-42003_2021_2140_MOESM6_ESM.txt--MXD1_MXD1 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN017_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.60168 H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XV7Q-1526-SM-4BRWB GTEx Tissue Sample Gene Expression Profiles 1.0 0.921584 BC-54-ON71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.384796 K562_EED226_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0185489 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11638 SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.46088 E2F6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149442_1_v_0_gdpd3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null single-organism cellular process GO Biological Process Annotations 2015 1.0 null pericentriolar material COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.43617 BACH1 ENCODE Transcription Factor Targets 1.0 null ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PBX3 ENCODE Transcription Factor Targets 1.0 null UCSD-242L Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38745 nifenazone-7314 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE158834_0_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE112760,GSE112767_1_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.844134 Crus 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90788 E2F4_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92455 GTEX-X4XY-1626-SM-46MVN GTEx Tissue Sample Gene Expression Profiles 1.0 1.31408 male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.51962 RH41 CCLE Cell Line Gene Expression Profiles 1.0 1.48068 GSE146074_10_v_3_ly6e_mouse RummaGEO Gene Perturbation Signatures 1.0 null K562_TG101209_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144071 skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -1.7907 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.553683 H4K20me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null fallopian tube HPA Tissue Gene Expression Profiles 1.0 1.3551 GSE213588_8_v_7_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null gamma-tubulin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.488 Ciliary vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.166 TEAD4 ChEA Transcription Factor Targets 1.0 null H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null dizocilpine-6223 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-MXD1_MXD1 Rummagene Transcription Factor Associations 2026 1.0 null nucleus subceruleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.987277 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.652183 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.847938 GSE145323,GSE145324_3_v_2_rfx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null MCF7_AT9283_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0111037 VMRCRCZ CCLE Cell Line Gene CNV Profiles -1.0 -1.70055 Primary microcephaly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.864 hsa-miR-4526 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 RAD21_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null QA-50-YO37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.287005 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A69Q-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042463 amygdalohippocampal transition zone, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.840892 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.50319 H3K4me1_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.21299 NRF1 ENCODE Transcription Factor Targets 1.0 null NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.909046 letrozole-4240 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null U-266 GDSC Cell Line Gene Expression Profiles 1.0 1.43125 NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE233049_1_v_3_atf3_human RummaGEO Gene Perturbation Signatures 1.0 null GSE193993_4_v_2_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-4741 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GSE195743_3_v_2_lhx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_Nintedanib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.014763 GSE201270,GSE201272_5_v_3_mybl2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE184892_4_v_5_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null superficial stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23143 fallopiantube_8d HPA Tissue Sample Gene Expression Profiles 1.0 1.01134 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24609 Precancerous Conditions CTD Gene-Disease Associations 1.0 1.23392 Elf5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 69.9891 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.10881 GTEX-S7PM-0011-R5A-SM-3NM8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07807 A549_Trichostatin A_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0127647 protein complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE221932,GSE222115_0_v_1_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null tanespimycin-2666 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lobule III Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52766 intracellular organelle part GO Cellular Component Annotations 2015 1.0 null pancreas GTEx Tissue Gene Expression Profiles -1.0 -1.0329 propose GeneRIF Biological Term Annotations 1.0 null TAPBPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23404 Spleen TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.17 POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9170110-pgen.1010161.s047.xlsx-DBP_DEP-nearestGene_DBP Rummagene Transcription Factor Associations 2026 1.0 null testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AU-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Septohippocampal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34091 microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.624781 r2 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12936 metampicillin-1440 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RNAi_-666_20953172 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11878 GSE239844_4_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null 496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.39094 GSE223908,GSE223909_4_v_8_serpinb3_human RummaGEO Gene Perturbation Signatures -1.0 null ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NE-94-VE83_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.446679 miconazole-4960 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null primary cilium COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.556467 TAK-901_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.00516034 GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZMIZ1 ENCODE Transcription Factor Targets 1.0 null GSE224096_2_v_0_cocaine_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NE-06A-21R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoskeleton GO Cellular Component Annotations 2025 1.0 null GSE185519_3_v_5_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null Flagellate TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.93 Lung adenocarcinoma_LUAD_TCGA-50-5066-02A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.33768 PAX5 ENCODE Transcription Factor Targets 1.0 null microtubule cytoskeleton GO Cellular Component Annotations 2025 1.0 null GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56444 Sperm flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.839 corticoid layer of TuStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55475 Kinesin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.446 pentolonium-2343 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null prostate carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.362978 SW626 COSMIC Cell Line Gene Mutation Profiles 1.0 null SA-32-CC58_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.582078 Primary somatosensory area, nose, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02106 GTEX-RNOR-2226-SM-2TF5O GTEx Tissue Sample Gene Expression Profiles 1.0 1.08345 Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Acrosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.588 AC-36-SY22_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.219389 GADD45B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1655 H4K8ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE217452_3_v_1_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null CAKI1 CCLE Cell Line Gene Expression Profiles -1.0 -1.74131 Hydrocephalus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.255 CFTR_Deficiency_GDS1843_191_mouse_Lungs - Animals examined at 3 weeks of age GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null K562_Clevudine_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0190687 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JAK1_knockdown_160_GSE37012 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.49604 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6950-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE143643,GSE143644_4_v_5_hdac3_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lateral part of cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.501 BV173 CCLE Cell Line Gene CNV Profiles -1.0 -1.9199 CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Agranular insular area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16768 Lung adenocarcinoma_LUAD_TCGA-69-7979-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13772 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3YS-01A-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null GSE224131_3_v_1_mafb_human RummaGEO Gene Perturbation Signatures 1.0 null GRSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34664 SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE123372,GSE123373_10_v_2_mecp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE239844_4_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-203-ZNF79_ZNF79 Rummagene Transcription Factor Associations 2026 1.0 null Gustatory areas, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14168 GTEX-S32W-1426-SM-4AD66 GTEx Tissue Sample Gene Expression Profiles 1.0 0.930162 HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.886891 GSE120200,GSE127269_1_v_2_asxl1_human RummaGEO Gene Perturbation Signatures -1.0 null ARID3A ENCODE Transcription Factor Targets 1.0 null inner ear TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.157533 SNU1214 CCLE Cell Line Gene CNV Profiles 1.0 2.48754 amikacin-5314 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cerebellar cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30502 striatum (corpus striatum) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19092 GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles -1.0 -2.56099 alpha-yohimbine-5800 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.204923 GSE113734_1_v_0_qprt_human RummaGEO Gene Perturbation Signatures -1.0 null centrosomal GeneRIF Biological Term Annotations 1.0 null mecamylamine-7263 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HDAC6 ENCODE Transcription Factor Targets 1.0 null zaprinast-5349 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null indoprofen-3007 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AB-21-VE32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.388481 RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cilium organization GO Biological Process Annotations 2025 1.0 null PBX3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.203933 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A68C-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BLOC1S6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07707 Lung adenocarcinoma_LUAD_TCGA-91-6840-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null florfenicol-6460 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null dorsolateral part of m2A Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03263 VIIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.824854 ARHGEF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28516 GTEX-X4XX-2926-SM-3NMB1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0989 minaprine-4814 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE152441,GSE152442_6_v_3_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE128099,GSE128159_3_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null prenatal lethality MPO Gene-Phenotype Associations 1.0 null H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A549_Ki16425_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0158776 posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.09221 H3K4me1_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null deep layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05611 MCF7_Tozasertib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0220785 H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OOBK-2126-SM-3LK5T GTEx Tissue Sample Gene Expression Profiles 1.0 2.3789 HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.86854 terguride-5694 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cell development GO Biological Process Annotations 2015 1.0 null PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR Rummagene Transcription Factor Associations 2026 1.0 null precommissural nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.964579 GSE196699_4_v_3_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12919 OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.916296 NKX2-3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.881 CRCGN010_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.45055 Astral microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.641 Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tiratricol-2096 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Centralspindlin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.937 18593951-TableS3 GeneSigDB Published Gene Signatures 1.0 null H3ac_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00288 corticoid layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.84713 RAD21_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Cediranib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0138674 GSE139455_2_v_5_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE147613_1_v_0_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE146072_0_v_1_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_NES-Unnamed_1_ZNF385A Rummagene Transcription Factor Associations 2026 1.0 null VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.56177 triflusal-7451 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K9ac_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17660535-TableS4a GeneSigDB Published Gene Signatures 1.0 null GSE210377_0_v_1_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null CRCGN016_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.32299 MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03329 SPI1_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1184 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MZ2-MEL COSMIC Cell Line Gene Mutation Profiles 1.0 null intracellular membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.387365 NCI-H1623 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1 Rummagene Transcription Factor Associations 2026 1.0 null B4GALT6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03604 VIIB Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.871077 GSE202434,GSE202438_4_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null nifedipine-1814 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Olfactory tubercle, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55984 GTEX-T2IS-2626-SM-32QPP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.04166 EID2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10789 b-cell lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.175411 E2F6 ENCODE Transcription Factor Targets 1.0 null binding GO Molecular Function Annotations 2015 1.0 null SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null embryonic lethality before implantation, complete penetrance MGI Mouse Phenotype Associations 2023 1.0 null type 2 diabetes mellitus GWASdb SNP-Disease Associations 1.0 0.63232 NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT474 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.36737 intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.536594 184B5 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.10639 Lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.096 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68314 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4725-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GSE103068_5_v_4_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null K562_AG-14361_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0254865 caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.70653 GSE126463_0_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null spiral organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.271256 GSE131887_1_v_2_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE111247_11_v_5_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null RELA_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-7662-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-610 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 GSE261563_0_v_1_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null GSE48812_9_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null salsolidin-4226 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NB10 DepMap CRISPR Gene Dependency 1.0 5.58073 GSE131649_6_v_8_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null Hypothalamus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.043 CRCGN015_HEPG2_48H:E16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.40913 PMC7825356-8844261.f3.docx-269-ZNF418_ZNF418 Rummagene Transcription Factor Associations 2026 1.0 null hypoglossal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.03652 GTEX-U4B1-1526-SM-4DXSL GTEx Tissue Sample Gene Expression Profiles 1.0 1.9159 r3 part of the trigeminal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0627 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MCF7_Toremifene Citrate_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144899 cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.927649 Nucleus accumbens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.45008 embryonic stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.282837 primary auditory cortex (core)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.873441 MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE235587_2_v_0_mitoxantrone_human RummaGEO Drug Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17X-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE193258,GSE193259_9_v_14_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Fluorouracil_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142077 IL9 MSigDB Cancer Gene Co-expression Modules 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-Y8-A894-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPD_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:I11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.28338 Sarcoma_SARC_TCGA-FX-A2QS-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3074-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.33042 NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE226285_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null BICR18 CCLE Cell Line Gene CNV Profiles 1.0 3.27648 acquired metabolic disease GWASdb SNP-Disease Associations 1.0 0.150914 carbamazepine-5518 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BCL6B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.7202 MFE280 CCLE Cell Line Gene CNV Profiles 1.0 1.82063 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Symbol_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_SIN3A_21632747 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null chlorogenic acid-1346 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7742-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13788 BMPR2 MSigDB Cancer Gene Co-expression Modules 1.0 null abnormal outer dense fiber morphology MGI Mouse Phenotype Associations 2023 1.0 null vegetative cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.212586 H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.028416 DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.732117 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5436-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29474 POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles -1.0 -2.06713 hsa-miR-135b TargetScan Predicted Conserved microRNA Targets 1.0 0.598666 GSE128730_3_v_5_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null aceclofenac-7269 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Autosomal dominant polycystic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.187 ZFC3H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37785 GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.977975 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.61903 Parabrachial nucleus, lateral division, dorsal lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15514 Acute Myeloid Leukemia_LAML_TCGA-AB-2868-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial (fastigial) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08582 STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null latex TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.297806 hsa-miR-892b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 PMC6791377-oncotarget-10-5768-s002.xlsx-Sheet1-Supplementary_Table_1_The_top_150_DEGs_downregulated_for_the_combined_dataset_of_MYC_silenced_versus_non_silenced_AGP01_cells_MYC Rummagene Transcription Factor Associations 2026 1.0 null RL7 BioGPS Cell Line Gene Expression Profiles -1.0 -2.86337 PANC0213 CCLE Cell Line Gene CNV Profiles 1.0 1.41707 GSE126345_0_v_10_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE242290_3_v_2_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WL46-3026-SM-3LK7Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.19868 DOK GDSC Cell Line Gene Expression Profiles -1.0 -1.95529 PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-V1D1-0008-SM-4JBIJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.16119 GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.68348 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Folium-tuber vermis (VII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.22179 colorectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063159 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.10525 spermatid TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.13191 ZC3H11A ENCODE Transcription Factor Targets 1.0 null GTEX-XMD1-0011-R11A-SM-4AT5J GTEx Tissue Sample Gene Expression Profiles 1.0 0.992935 Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4116-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Tofacitinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167681 H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null chloropyrazine-5750 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PF-382 COSMIC Cell Line Gene Mutation Profiles 1.0 null recruits GeneRIF Biological Term Annotations 1.0 null diethylcarbamazine-7425 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AN3-CA COSMIC Cell Line Gene Mutation Profiles 1.0 null NELFE ENCODE Transcription Factor Targets 1.0 null KM-12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null cerebellum_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.945554 GSE186767_1_v_0_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null Vas deferens TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.284 Ciliary basal body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.205 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCNA1 MSigDB Cancer Gene Co-expression Modules 1.0 null GTEX-T6MN-2726-SM-4DM77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32468 GTEX-QDVN-1126-SM-48TZ7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.02338 pineal body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.934586 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XPT6-0001-SM-4B64G GTEx Tissue Sample Gene Expression Profiles 1.0 0.876072 inner CP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26532 YY1 ChEA Transcription Factor Targets 1.0 null GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77462 GSE258991_5_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null OVMANA CCLE Cell Line Gene Expression Profiles -1.0 -2.08933 NALM19 CCLE Cell Line Gene Expression Profiles 1.0 1.80664 CRCGN012_HEPG2_24H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3292 GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852958 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MA-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organelle part GO Cellular Component Annotations 2015 1.0 null BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MCF7_PF-573228_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0230628 GSE220806_0_v_3_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE151412_2_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null DA-10-GX45_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.322801 GTEX-XXEK-0126-SM-4BRVU GTEx Tissue Sample Gene Expression Profiles 1.0 1.11295 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null Blood TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE203308_14_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE184479_1_v_2_aim2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE135514_8_v_7_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5465 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860133 NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.981925 PMC9174260-41467_2022_30960_MOESM6_ESM.xlsx-S3-RAS2_unique_GATA2-Gene_GATA2 Rummagene Transcription Factor Associations 2026 1.0 null HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OVMANA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.17722 GTEX-Q2AG-2826-SM-2HMJQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.16241 K562_KW-2449_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0209595 PNU-0230031-4288 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null outer CP in (rostral) midinferior temporal cortex (area 36) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16491 amprolium-4241 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GD-59-OG21_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.278001 MCF7_SRT2104_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142477 MCF7_ENMD-2076_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154389 GSE205730,GSE205731_2_v_1_tazemetostat_human RummaGEO Drug Perturbation Signatures -1.0 null NFYB ENCODE Transcription Factor Targets 1.0 null PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5 Rummagene Transcription Factor Associations 2026 1.0 null GSE212772_0_v_1_ncoa4_mouse RummaGEO Gene Perturbation Signatures -1.0 null cytoplasm LOCATE Curated Protein Localization Annotations 1.0 null GSE179880_10_v_3_e2f4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Sertoli cell-only syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.171 GSE205163,GSE205164_2_v_0_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null layer V of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05194 SCLY ChEA Transcription Factor Targets 1.0 null H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XAJ8-1026-SM-47JY9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05365 GTEX-QVUS-2926-SM-3GIJB GTEx Tissue Sample Gene Expression Profiles 1.0 1.04079 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7864-01A-11R-2232-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Spermatid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.13 GSE195559_3_v_1_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null amygdaloid complex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.835776 PD-70-VS77_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.799897 PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-N7MT-1026-SM-3TW8T GTEx Tissue Sample Gene Expression Profiles 1.0 1.45164 Valdecoxib_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0211645 PMC9314667-Table_1.xlsx-Regulons-FOSL2_FOSL2 Rummagene Transcription Factor Associations 2026 1.0 null rnf2_20123906_mouse_embryonic_stem_cell_lof_mouse_gpl1261_gse19076 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.458339 E2F1 JASPAR Predicted Transcription Factor Targets 1.0 null GSE193258,GSE193259_2_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE118794_0_v_1_zmynd8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-NL3H-0011-R11A-SM-2I3E6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.851133 Adenoma, Liver Cell CTD Gene-Disease Associations 1.0 1.16001 septopallidal shell area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7511 Hyperplasia CTD Gene-Disease Associations 1.0 1.73878 K562_CEP-33779_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151342 H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FOXM1-23109430-U2OS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null WNT1 MSigDB Cancer Gene Co-expression Modules 1.0 null H3K79me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE113817_2_v_1_bach1_human RummaGEO Gene Perturbation Signatures 1.0 null YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null protein complex GO Cellular Component Annotations 2015 1.0 null propofol-6707 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null SU8686 CCLE Cell Line Gene Expression Profiles -1.0 -1.4747 H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ketorolac-5988 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE190322,GSE190324_3_v_4_rbm4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-43-A56U-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null chlorambucil-3788 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WVLH-2926-SM-3MJG5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11189 GSE112860_0_v_2_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null K562_Meprednisone_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.01861 H9 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.15307 cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.301054 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null GSE211177,GSE211178_4_v_10_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE209582_1_v_3_chloroquine_human RummaGEO Drug Perturbation Signatures -1.0 null ELK4 ENCODE Transcription Factor Targets 1.0 null 496100327_PCx_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.4964 CRCGN012_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.05643 BRCA1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4675 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 amygdaloid complex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03144 trifluoperazine-1224 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null znf217_22593193_mda_mb_231_gof_human_gpl570_gse35511 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.532374 GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60191 SNRPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.55993 NCI-H441 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.845406 spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.85505 HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.921731 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null STAT3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3B-Up_Dpy30_KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null CW-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Procentriole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.236 CRCGN008_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5956 H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE88819_6_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null 7164_RBM22_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.586792 cell cortex part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.062776 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null spindle pole GO Cellular Component Annotations 2015 1.0 null LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.1153 ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STOCK1N-35215-6380 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null GSE169152_5_v_0_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null RCC4 CCLE Cell Line Gene Expression Profiles -1.0 -1.64736 wortmannin-4467 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null abnormal sperm axoneme morphology MPO Gene-Phenotype Associations 1.0 null GSE176008_7_v_2_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null inferior olive, medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.68137 MCF7_Avagacestat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153566 K562_Alisertib_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.014476 urinary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.047926 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null motif GeneRIF Biological Term Annotations 1.0 null CRCGN015_HEPG2_48H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.31959 Prostate adenocarcinoma_PRAD_TCGA-YL-A8SL-01B-21R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null axoneme part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.36472 MCF7_JQ1_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0227293 GSE158632_3_v_4_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null adiphenine-1872 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE140200_1_v_3_trim59_mouse RummaGEO Gene Perturbation Signatures 1.0 null K562_Disulfiram_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0182475 GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40791 PANC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.846409 GSE112762,GSE112767_2_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures 1.0 null A549_JQ1_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.013157 Congenital nervous system abnormality DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.533 CRCGN011_HEPG2_24H:C17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1081 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MSTO-211H COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SYK_druginhibition_283_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.70785 H3C3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47332 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null abnormality of the endocrine system GWASdb SNP-Phenotype Associations 1.0 0.078765 POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-2526-SM-2D7W3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14316 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 horizontal nucleus of the diagonal band Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19992 polymorph layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.79217 hsa-miR-3926 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Sperm principal piece COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GTEX-S7SE-2526-SM-2XCDL GTEx Tissue Sample Gene Expression Profiles 1.0 0.995302 Assembly of the primary cilium Reactome Pathways 2014 1.0 null GSE198165,GSE198166_0_v_4_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE103068_5_v_7_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null outer CP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.30753 H3K27ac_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null testis_7a HPA Tissue Sample Gene Expression Profiles 1.0 1.47393 ZFP42 ChEA Transcription Factor Targets 1.0 null EW-1 GDSC Cell Line Gene Expression Profiles 1.0 2.00374 GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.84471 CRCGN008_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7872 haloperidol-1244 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZBTB7A ENCODE Transcription Factor Targets 1.0 null GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41333 Oviduct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.39 fenofibrate-7474 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.858309 NR6A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4632 PDX1 JASPAR Predicted Transcription Factor Targets 1.0 null NR1D1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.0603 K562_Azacitidine_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0143671 PMC11096100-41588_2024_1714_MOESM3_ESM.xlsx-ST18-Unnamed_1_ST18 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE154074_2_v_4_bleomycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null respiratory system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052653 GSE144231_2_v_1_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN015_MCF10A_48H:C04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.03263 RORA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0689 MCF7_Curcumin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0189584 NCI-H28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.905686 GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.942838 intermediate stratum of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17045 intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058143 HS 675.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.43092 GSE161846,GSE161849_3_v_0_smarca4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE148200_0_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null PMC8466366__F1 PFOCR Pathway Figure Associations 2024 1.0 null JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.9967 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null rt4 HPA Cell Line Gene Expression Profiles -1.0 -0.967572 meticrane-1834 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FA-88-II68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.67307 aminohippuric acid-6453 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Centriole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.918 H3K79me2_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null Recruitment of mitotic centrosome proteins and complexes Reactome Pathways 2014 1.0 null GSE233049_2_v_0_atf3_human RummaGEO Gene Perturbation Signatures 1.0 null PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.291047 IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.972602 GSE101336_1_v_0_decitabine_mouse RummaGEO Drug Perturbation Signatures 1.0 null MCF7_Pelitinib_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0109677 HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.995366 MRPS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39917 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A195-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PX3G-1626-SM-2S1PT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05568 GSE225869_1_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null GSE111247_14_v_10_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null ETS1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATP5F1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03247 GSE210101,GSE210114_6_v_10_urod_human RummaGEO Gene Perturbation Signatures 1.0 null hESC Derived CD184+ Endoderm Cultured Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.07416 GTEX-RUSQ-2126-SM-47JXK GTEx Tissue Sample Gene Expression Profiles 1.0 1.86414 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hcenexin1 GeneRIF Biological Term Annotations 1.0 null OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25884 GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42714 germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.496874 Zileuton_AN3 CA Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0126899 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null GSE111385_0_v_3_tgfbr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Bisoprolol (hemifumarate)_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00992278 GSE131377_1_v_0_spocd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Immune system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Brain Lower Grade Glioma_LGG_TCGA-FG-5963-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-6597-01A-11R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amprolium-4825 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE162087_0_v_1_dexamethasone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Agranular insular area, ventral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5624 H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.80468 TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ASXL1 ChEA Transcription Factor Targets 1.0 null PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-VUSG-2226-SM-4KKZO GTEx Tissue Sample Gene Expression Profiles 1.0 0.932636 GSE169356_0_v_1_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null Declive (VI), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6424 NFYB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_SRT3025 HCl_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0152356 CUX1 ENCODE Transcription Factor Targets 1.0 null intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.34767 intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE145323,GSE145324_1_v_0_rfx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE181513_0_v_1_usp7_human RummaGEO Gene Perturbation Signatures -1.0 null GSE118766_2_v_0_ifng_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE227891_5_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE142588_2_v_1_cinobufagin_human RummaGEO Drug Perturbation Signatures -1.0 null cone-rod dystrophy 20 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.475 ZNHIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39879 K562_Ki16425_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0205867 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GY-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r1 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72483 GSE152441,GSE152442_1_v_3_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.39941 spermatid development GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-53-A4EZ-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33485 GSE174522_1_v_0_spp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ATG4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12585 burkitt lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.435651 ATF3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCAS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.853706 Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.970599 KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.983948 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051038 splicing Phosphosite Textmining Biological Term Annotations 1.0 null SUP-B15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28463 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE226249_0_v_8_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-375 MiRTarBase microRNA Targets 1.0 null mianserin-1385 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null sympathetic nervous system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.17409 496100485_PCx_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.4234 intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.489327 GSE166920_6_v_5_adalimumab_human RummaGEO Drug Perturbation Signatures -1.0 null Nevirapine_BT-474 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00467968 SVIL Pathway Commons Protein-Protein Interactions 1.0 null superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.28982 MCF7_Zileuton_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0132056 CRCGN016_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.85971 NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.973505 GSE111247_14_v_3_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null central subpallium (classic basal ganglia) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00792 H3K27ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SP in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.900603 NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.26128 PMC3573729-nl3042917_si_005.xlsx-OWY_Overlap_with_ANOVA-ORKIN_ZFX_ZFX Rummagene Transcription Factor Associations 2026 1.0 null MTF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.5265 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null localizes GeneRIF Biological Term Annotations 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FD-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Tacedinaline_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0155934 BE-27-RQ61_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.40368 posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.853953 BBSome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.638 GTEX-SSA3-0326-SM-32QPS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11874 H3K4me3_Adult Kidney Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE126463_0_v_2_arid2_human RummaGEO Gene Perturbation Signatures -1.0 null Spermatogenic failure 53 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.785 Stereocilium bundle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.032 non-motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.589 H3K79me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 5659_NGDN_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.76377 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE102505_6_v_0_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null dapsone-1827 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE143512,GSE143513_0_v_1_nr4a3_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC10039511-12864_2023_9238_MOESM1_ESM.xlsx-LPS_group-Unnamed_1_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S3XE-0426-SM-3K2AC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892718 Penis_Foreskin_Fibroblast_Primary_Cells_skin02 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.20676 GTEX-XYKS-1626-SM-4BRUQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.07838 H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EZH2 ENCODE Transcription Factor Targets 1.0 null GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45772 GSE211215_1_v_0_pemetrexed_human RummaGEO Drug Perturbation Signatures -1.0 null PMC7430827-12864_2020_6933_MOESM4_ESM.xlsx-Sheet1-Additional_file_4_Table_S4_A_list_of_3_062_genes_containing_locus_where_only_KD_had_non-synonymous_SNPs_compared_to_other_duck_breeds_AR Rummagene Transcription Factor Associations 2026 1.0 null amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26622 NCIH650 DepMap CRISPR Gene Dependency 1.0 2.07366 GSE114232_8_v_6_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE203308_15_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null A549_Linifanib_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0160199 abnormality of metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.047757 Declive (VI), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83789 ELF1 ChEA Transcription Factor Targets 1.0 null piperidolate-6772 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SP1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A54R-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pancreas_6b HPA Tissue Sample Gene Expression Profiles -1.0 -0.937866 Teratocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.163 GTEX-T6MN-1226-SM-3NMA5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01416 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.846882 KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Oligospermia CTD Gene-Disease Associations 1.0 1.16269 GFAP_OE_GDS1488_254_mouse_Olfactory bulb of 23 day old GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE94011_0_v_3_pias3_mouse RummaGEO Gene Perturbation Signatures -1.0 null KMRC3 CCLE Cell Line Gene Expression Profiles -1.0 -2.41393 HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7368-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 9+2 motile cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 propoxycaine-7155 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.66786 glucose metabolism disease GWASdb SNP-Disease Associations 1.0 0.269253 Sarcoma_SARC_TCGA-DX-A6YV-01A-12R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XOTO-2926-SM-4B65G GTEx Tissue Sample Gene Expression Profiles 1.0 0.981548 leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE113106_0_v_4_dnm2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-TMZS-0326-SM-3DB9P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67176 PMC11221067-JCMM-28-e18520-s002.xlsx-Supplementary_Table_2-MXD1_MXD1 Rummagene Transcription Factor Associations 2026 1.0 null novobiocin-437 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null pentolonium-3676 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ATF3 ENCODE Transcription Factor Targets 1.0 null Primary somatosensory area, lower limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27723 GSE239844_1_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34863 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null G2/M Transition Reactome Pathways 2014 1.0 null GSE226249_5_v_3_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null acenocoumarol-1394 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE147662_0_v_1_nicotinamide_mouse RummaGEO Drug Perturbation Signatures -1.0 null PF-00562151-00-5922 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null organelle organization GO Biological Process Annotations 2025 1.0 null Sox11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 98.3537 GSE233679_5_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4B-Up_Nanog_KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null somatic GeneRIF Biological Term Annotations 1.0 null ZNF214 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6021 LCAT MSigDB Cancer Gene Co-expression Modules 1.0 null occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26189 intracellular organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07846 GSE199204,GSE211619_4_v_5_glutamine_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN014_HEPG2_3H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0332 GSE123861_1_v_0_sin3a_human RummaGEO Gene Perturbation Signatures 1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27408 PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-2_E2F1-Gene_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null CP in rostral hippocampus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.39576 WC-59-RG09_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210634 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.099 Nr5a1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.0332 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Roxadustat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0217657 GSE199204,GSE211619_4_v_0_glutamine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE111138,GSE111149_1_v_0_runx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null mantle zone of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03206 Lobules IV-V, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.69814 haloperidol-2039 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-N7MT-0726-SM-3TW8S GTEx Tissue Sample Gene Expression Profiles 1.0 0.927034 Cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 SP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.0617 N-acetyl-L-aspartic acid-4007 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE138789_0_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null tribenoside-2946 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-T6MN-2026-SM-4DM7L GTEx Tissue Sample Gene Expression Profiles 1.0 3.02265 fenofibrate-2401 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null A204 GDSC Cell Line Gene Expression Profiles 1.0 1.50727 GTEX-XBEC-1326-SM-4AT69 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.934228 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.45984 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ChIP_ZFP42_18358816 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null HCT116 BioGPS Cell Line Gene Expression Profiles 1.0 1.04046 Mobilized_CD34_Primary_Cells_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.939478 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12500496-262_2025_4178_MOESM2_ESM.xlsx-THP1_enriched_for_control-gene_name_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QDT8-3026-SM-32PKB GTEx Tissue Sample Gene Expression Profiles 1.0 1.1904 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IX Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.29893 SARS-CoV MA15_Day1-PFU-10^4_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.37505 MCF7_AICAR_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156726 digits BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.957021 Bone marrow cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.38834 PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sensorineural hearing loss DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.465416 SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null asthenozoospermia MPO Gene-Phenotype Associations 1.0 null cell cycle process GO Biological Process Annotations 2015 1.0 null IGR1 CCLE Cell Line Gene CNV Profiles -1.0 -1.52824 g2 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.029 CRCGN009_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0215 GLI2 MotifMap Predicted Transcription Factor Targets 1.0 null MCF7_Tanespimycin_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.00898144 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2 ENCODE Transcription Factor Targets 1.0 null SKES1 CCLE Cell Line Gene CNV Profiles 1.0 2.15566 microtubule COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18638 GSE220613_0_v_1_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null retina BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.28434 GSE165647_6_v_3_cry2_mouse RummaGEO Gene Perturbation Signatures 1.0 null TAF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.15658 18614019-TableS4b GeneSigDB Published Gene Signatures 1.0 null hsa-miR-3140-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Cinacalcet_H4 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.015403 GSE152441,GSE152442_7_v_3_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230241 K562_TGX-221_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160591 STAT1 ENCODE Transcription Factor Targets 1.0 null ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PP-0008-SM-48TDV GTEx Tissue Sample Gene Expression Profiles 1.0 1.07323 embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.23083 GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59117 cdc2-protein-kinase Phosphosite Textmining Biological Term Annotations 1.0 null TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Regorafenib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146463 BCB000039-7510 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kinetochore COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.562 Sarcoma_SARC_TCGA-WK-A8XO-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.11049 CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NUGC4 CCLE Cell Line Gene CNV Profiles 1.0 1.82705 CFPAC1 CCLE Cell Line Gene Expression Profiles -1.0 -2.6046 RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.14498 PMC7388612-vdaa078_suppl_supplementary_table_6.xlsx-MRs_PN_Rim-vs-MRs_PN_C-MR_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08862 QA-34-PH05_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.267683 dorsal nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08663 IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null UT7 CCLE Cell Line Gene Expression Profiles 1.0 1.70547 Embryonic carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.795 FOXP2_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null organization GeneRIF Biological Term Annotations 1.0 null niflumic acid-5490 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Nematosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.688 GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.921719 Lung squamous cell carcinoma_LUSC_TCGA-70-6723-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPB_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6373-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.99854 GTEX-XUW1-1326-SM-4BOO1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.876049 IM-95 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.13175 K562_Sodium Phenylbutyrate_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167568 anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.79553 CTCF ENCODE Transcription Factor Targets 1.0 null GTEX-UTHO-2926-SM-3P5Z9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22106 1min_EGF vs ctrl_HeLa (Human) [17081983] SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands 1.0 null component GeneRIF Biological Term Annotations 1.0 null GTEX-RM2N-1126-SM-48FCY GTEx Tissue Sample Gene Expression Profiles 1.0 0.859115 PRR29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21148 496100616_FWM_no dementia_TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.27732 IV, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.859697 POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131649_2_v_3_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null MAX ENCODE Transcription Factor Targets 1.0 null medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24257 A549_Anacardic Acid_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0194279 RFX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1248 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV MA15_Day7-PFU-10^5_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.75798 PRDM5-23873026-MEF-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null TET1 ChEA Transcription Factor Targets 1.0 null GTEX-X585-0011-R11B-SM-46MUZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.924627 GTEX-T6MN-0002-SM-3NMAH GTEx Tissue Sample Gene Expression Profiles 1.0 0.855238 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25723 GSE114690_1_v_0_tnfsf14_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-7713-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null isthmus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31466 GR MotifMap Predicted Transcription Factor Targets 1.0 null GSE158632_3_v_0_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null GSE135030_8_v_7_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE240258_0_v_1_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PHGDH_KO_GDS2874_125_mouse_embryonic head tissue GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null colon sigmoideum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.660304 Sperm principal piece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.227 POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GW-8510-7067 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LD-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR2F2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 15845616-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null MCF7_Bosutinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0184191 PMC7672319-mmc3.xlsx-DREAM_MSigDB62-FISCHER_DREAM_TARGETS_KCNIP3 Rummagene Transcription Factor Associations 2026 1.0 null nalidixic acid-2297 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null USF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gliclazide-1720 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA5_KO_GSE47425_50_mouse_lung GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null K562_Triamcinolone Acetonide_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.013541 U031 GDSC Cell Line Gene Expression Profiles -1.0 -1.45037 SK-MEL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.12236 mantle zone of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.80468 inner ear disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.41465 TE-11 GDSC Cell Line Gene Expression Profiles 1.0 2.3918 nematosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.03929 GSE77108_6_v_7_saha_human RummaGEO Drug Perturbation Signatures -1.0 null MALME 3M BioGPS Cell Line Gene Expression Profiles -1.0 -1.73485 EDD_DEPLETION_GDS2445_116_human_embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null T98G Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.846409 GSE195743_1_v_4_lhx6_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE112762,GSE112767_1_v_0_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null SP1 Pathway Commons Protein-Protein Interactions 1.0 null nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 teratocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.760742 MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61618 Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DBTRG05MG DepMap CRISPR Gene Dependency 1.0 6.62927 non-hodgkin lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.117856 hippocampus (hippocampal formation)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.10818 chr9_128441295_C_A_b38 GTEx eQTL 2025 1.0 1.08529 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NB7 DepMap CRISPR Gene Dependency 1.0 4.32681 plexiform layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.04184 GTEX-REY6-0126-SM-48FDT GTEx Tissue Sample Gene Expression Profiles 1.0 2.81335 GTEX-RN64-1026-SM-48FDX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828729 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.638278 FOXM1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JURLMK1 CCLE Cell Line Gene CNV Profiles -1.0 -2.27858 LN-18 COSMIC Cell Line Gene Mutation Profiles 1.0 null NRDE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29573 GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.839763 spinal (inferior) vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.838318 GTEX-WZTO-2826-SM-3NM8P GTEx Tissue Sample Gene Expression Profiles 1.0 0.984331 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Accessory sex gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.38 CEBPB_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell part LOCATE Predicted Protein Localization Annotations 1.0 null Testis BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.71476 GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 1.56379 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE71385_1_v_2_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null milrinone-5856 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MLX_TESTES_MLX Rummagene Transcription Factor Associations 2026 1.0 null NCIH1563 CCLE Cell Line Gene Expression Profiles -1.0 -2.24879 PBX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.65903 idoxuridine-4200 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null K562_Ruxolitinib_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0158653 orphenadrine-3801 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null pallidal islands of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47227 basomedial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.86787 NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54544 ZNF275 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21004 Middle ear TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.724 SW1116 CCLE Cell Line Gene CNV Profiles 1.0 2.16493 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Tracheal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.196 CAL27 CCLE Cell Line Gene CNV Profiles 1.0 1.42039 GSE125007,GSE125008_6_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21631 ZNF189 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5765 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-P4QS-2026-SM-3NMCG GTEx Tissue Sample Gene Expression Profiles 1.0 0.902037 PMC4067464-onc2013378x3.xls-Sheet1-Supplementary_Table_1_Top_1000_E2F4_Chip-Seq_targets_that_are_repressed_by_p53_E2F4 Rummagene Transcription Factor Associations 2026 1.0 null Cell Cycle, Mitotic Reactome Pathways 2024 1.0 null HEY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.955921 PMC3371315-NIHMS350140-supplement-12.xls-MCF7-T47D-SK-453_Down_Common_xl-Supplementary_Table_5_Luminal_Signature_Genes_decreased_in_all_four_cell_lines_MCF7_T47D_MB-453_SKBR3_with_knockdown_of_FOXA1_FOXA1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary somatosensory area, mouth, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18381 Meckel syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.584 GSE196699_0_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Baboon_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.164359 salivarygland BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.8456 nimesulide-7024 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Midbody COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.698 18277965-TableS1b GeneSigDB Published Gene Signatures 1.0 null GTEX-RVPU-0011-R3A-SM-2XCAE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.940013 GSE114883_1_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null septostriatal part of the olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.70133 bladder wall TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.432225 eye TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NUGC2 CCLE Cell Line Gene CNV Profiles 1.0 1.36201 ELF5 ChEA Transcription Factor Targets 1.0 null USF2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D4-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00358 cone-rod dystrophy 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.088 GTEX-VJWN-0426-SM-3GIJI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845082 POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39716 GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.880629 MKN28 DepMap CRISPR Gene Dependency 1.0 13.4146 PMC10928104-41419_2024_6576_MOESM4_ESM.xlsx-S14-MYBL2_targets_MYBL2 Rummagene Transcription Factor Associations 2026 1.0 null gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.434906 GSE223334_3_v_2_bcl11b_mouse RummaGEO Gene Perturbation Signatures 1.0 null Bulbourethral gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.358 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null E2F6_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of plasma membrane bounded cell projection assembly GO Biological Process Annotations 2025 1.0 null CRCGN008_HEPG2_24H:L15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6871 blood cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16351 viomycin-3541 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DT-40 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.535 Outer acrosomal membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.288 embryo TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065452 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A439-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07518 CRCGN016_MCF10A.TP53.M_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.37599 OBSL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60996 creb1_22108299_lung_lof_mouse_gpl1261_gds3660 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.007265 UACC-812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.846409 POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cerebral degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.082 Lung squamous cell carcinoma_LUSC_TCGA-43-7658-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A549_Valproic acid sodium salt_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0223388 GSE142684_0_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null Cell projection membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.615 Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NA-A5I1-01A-21R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNMC-0126-SM-2XCFO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02473 CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Trichostatin A_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0166229 CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17683518-813GeneTable GeneSigDB Published Gene Signatures 1.0 null sulfadiazine-5523 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BICR 22 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.54979 cerebellar cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0457 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.26578 GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.3749 cytoskeletal part GO Cellular Component Annotations 2015 1.0 null GTEX-XMK1-0005-SM-4B665 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93648 Rotavirus infection of children_Peripheral blood mononuclear cell_GSE2729 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.5524 gamma-tubulin large complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.884 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.365477 cefotaxime-5830 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE141328_3_v_2_rock2_mouse RummaGEO Gene Perturbation Signatures -1.0 null propylthiouracil-4076 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null PRC2_EDD_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05554 GSE178340_5_v_3_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null HCC89 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.9482 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1838 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01904 PPP3CA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19115 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.34459 ciliary part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.167366 K562_EED226_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0151716 CRCGN008_HEPG2_24H:L14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.869 GTEX-UPK5-2026-SM-4JBIM GTEx Tissue Sample Gene Expression Profiles 1.0 1.09713 GSE131649_2_v_8_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07518 GSE139455_2_v_3_stat3_human RummaGEO Gene Perturbation Signatures -1.0 null NFKB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.2501 GSE58724_1_v_4_oxymetholone_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4V-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZCCHC24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12476 GSE223893_1_v_10_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE193258,GSE193259_5_v_6_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE57871_6_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null ribavirin-7316 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CAOV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.24585 SMIM12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0178 GSE197850_4_v_2_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null superficial stratum of SeStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7006 cnx GeneRIF Biological Term Annotations 1.0 null GSE202134_0_v_1_rbm39_human RummaGEO Gene Perturbation Signatures -1.0 null 19204204-SupplementaryTable5 GeneSigDB Published Gene Signatures 1.0 null GTEX-XXEK-1226-SM-4BRUY GTEx Tissue Sample Gene Expression Profiles 1.0 1.31021 SCYL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43733 Metaphase plate COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.353 POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153064,GSE153065_1_v_0_hdac3_mouse RummaGEO Gene Perturbation Signatures -1.0 null NFIC ENCODE Transcription Factor Targets 1.0 null cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 NCI-H2810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.824849 parietal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13777 H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null YY1-23942234-MYOBLASTS AND MYOTUBES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.501182 NU-1025-313 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.15207 RKO CCLE Cell Line Gene CNV Profiles 1.0 1.92434 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Fastigial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12059 intracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null SW 1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06107 PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P44H-0426-SM-2XCEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41169 PMC6438015-13148_2019_651_MOESM7_ESM.xlsx-Sheet1-Table_S2_Genes_exhibiting_both_significantly_increased_promoter_methylation_and_significantly_lowered_expression_in_CRISPR_TET2-KO_cells_TET2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XOTO-0526-SM-4B662 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59639 GSE162739_4_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Gustatory areas, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.02793 MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.12511 CRCGN017_MCF10A.TP53.M_24H:J08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.40902 PMC3573729-nl3042917_si_005.xlsx-OWY_Overlap_with_ANOVA-ORKIN_E2F4_E2F4 Rummagene Transcription Factor Associations 2026 1.0 null K562_Filgotinib_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0179502 GSE193624_1_v_0_med1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE246184,GSE246195_0_v_1_sin3a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Implantation fossa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.022 GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.956552 POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U9-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-58-A46L-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8995879-Table_1.xlsx-exome_variants_MAF_0_01-Gencode_34_hugoSymbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-3074-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 perilemniscal isthmic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18517 GTEX-PW2O-1426-SM-48TCD GTEx Tissue Sample Gene Expression Profiles 1.0 1.92132 POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE141328_1_v_0_rock2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PML ENCODE Transcription Factor Targets 1.0 null K562_SRT2104_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0183292 lisuride-6682 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RO-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE48812_2_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null ACYP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2228 CRCGN016_MCF10A.TP53.M_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5636 USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null formation GeneRIF Biological Term Annotations 1.0 null nomifensine-5863 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Huntington's Disease_Brain_GSE3621 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.58016 Mitotic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.849 SCAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5815 prazosin-3098 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76409 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZG-0326-SM-47JXN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37545 GSE149901_3_v_0_anlotinib_human RummaGEO Drug Perturbation Signatures -1.0 null 12829800-IntrinsicList GeneSigDB Published Gene Signatures 1.0 null Lingula (I) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1277 abnormal gametogenesis MPO Gene-Phenotype Associations 1.0 null 6237_PFDN1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.518745 microtubule organizing center COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null diazoxide-5810 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null mouth TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053791 GSE264621_1_v_3_secretin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE110268_1_v_3_foxd1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE184902_4_v_1_adipor1_mouse RummaGEO Gene Perturbation Signatures -1.0 null AA-23-FM46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.663496 Seminal plasma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.629 Intraciliary transport particle B COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.41 GGA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42267 r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09355 NO11 DepMap CRISPR Gene Dependency 1.0 4.74908 prepontine hindbrain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34713 MCF7_BMS-754807_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.027219 mediodorsal nucleus of thalamus_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29595 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NPHP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.291 MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null polymorph layer of TuStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.73925 GSE149035_2_v_0_hepacam_human RummaGEO Gene Perturbation Signatures -1.0 null Spina bifida DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.128 Ovotestis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.984 Primary ciliary dyskinesia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.536 GSE234289_4_v_2_rfx6_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82145 KP-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.972473 UFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0597 GSE234340_1_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PBX3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU489 CCLE Cell Line Gene CNV Profiles 1.0 1.35114 GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86433 Testicular cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.387 COV644 DepMap CRISPR Gene Dependency 1.0 2.05539 FARAGE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null CRCGN014_HEPG2_3H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.9744 GTEX-T2IS-0011-R11A-SM-32QPC GTEx Tissue Sample Gene Expression Profiles 1.0 0.83085 ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Thiotepa_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147346 TBP_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10049 PANC 04.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.2025 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-5963-02A-12R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Cerdulatinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0197255 PMC12184404-jitc-13-6-s004.pdf-3-FOXO4_FOXO4 Rummagene Transcription Factor Associations 2026 1.0 null enzalutamide_homo sapiens_gpl570_gse44905 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE223893_4_v_10_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null III Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19234 FOSL2::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.8219 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IM-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28178 cell projection part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.711465 GTEX-TMZS-0001-SM-3P61Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.00784 GSE114992,GSE114993_9_v_2_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null Manchette COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.722 K562_INO-1001_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0208952 CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null teratozoospermia MPO Gene-Phenotype Associations 1.0 null GSE130081,GSE130082_5_v_1_neil2_mouse RummaGEO Gene Perturbation Signatures 1.0 null ITGB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31422 K562_PD98059_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0205128 GSE108675_2_v_1_slc1a4_mouse RummaGEO Gene Perturbation Signatures 1.0 null Uvula (IX), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27264 abnormal motile cilium morphology MPO Gene-Phenotype Associations 1.0 null H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null u26684 HPA Cell Line Gene Expression Profiles 1.0 1.45812 POU4F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.9828 niridazole-5682 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE198165,GSE198166_7_v_1_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23934 H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CREB1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE212760_0_v_1_fxr1_human RummaGEO Gene Perturbation Signatures -1.0 null PRSS22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91926 GSE88819_1_v_2_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE122425_1_v_0_nsun2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE245778_1_v_0_runx1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29974 Dihydroartemisinin_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.010107 CAL-148 COSMIC Cell Line Gene Mutation Profiles 1.0 null COLO-741 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUM185PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.645398 organelle part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YV-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RM-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE198165,GSE198166_6_v_11_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null PBX3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UACC-257 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04188 Bone marrow TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.152 GSE248045,GSE248046_0_v_5_runx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN014_HEPG2_3H:L10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48183 H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38745 hsa-miR-526a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09079 MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44962 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-JV-A5VF-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE215086_0_v_2_batf_human RummaGEO Gene Perturbation Signatures -1.0 null HNF1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 31.4796 Adrenocortical carcinoma_ACC_TCGA-OR-A5JJ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Baricitinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0170384 PFKL_OE_GDS3353_76_human_B cells in blood GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.181764 CRCGN017_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.07225 H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null DAUDI COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40894 H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Microtubule organizing center COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 H3K79me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DE-01A-22R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE154577_7_v_10_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null Olfactory tubercle, polymorph layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61588 Crus 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92037 CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Plasma membrane bounded cell projection COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 L-428 GDSC Cell Line Gene Expression Profiles 1.0 2.51391 central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 Diabetes Mellitus CTD Gene-Disease Associations 1.0 1.04352 H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE127790_9_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Plantlet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.252 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_CH12.LX_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7477-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GSE111247_2_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null CREB1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE116810_2_v_4_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC2185 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.63903 primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.61115 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sperm head COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.113 AE-39-DG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.468821 REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CI-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE229914_1_v_3_keap1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE131649_6_v_0_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null Parabrachial nucleus, lateral division, superior lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00012 NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4N-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null U2AF1_02_165 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60504 periventricular stratum of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51762 GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.58203 Cystic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.734 GSE211128_3_v_6_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null Nuclear microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.804 suramin sodium-7529 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.987317 GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37673 cell-cycle-proteins Phosphosite Textmining Biological Term Annotations 1.0 null GSE181003_3_v_2_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.43414 Prospore contractile ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.947 CB-16-SY72_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.357392 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null compared GeneRIF Biological Term Annotations 1.0 null cellular_component LOCATE Curated Protein Localization Annotations 1.0 null Mitotic spindle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.911 MAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78582 GSE128730_0_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE162892_3_v_0_isox_human RummaGEO Drug Perturbation Signatures -1.0 null central gray of the pons, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.16487 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE112995,GSE132079_1_v_3_ezh2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WCDI-0008-SM-47JYE GTEx Tissue Sample Gene Expression Profiles 1.0 1.03642 seminiferous tubule TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.644074 hsa-miR-3660 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 carteolol-1340 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE236003_1_v_3_ubr5_human RummaGEO Gene Perturbation Signatures 1.0 null GSE156907,GSE160237_1_v_0_pten_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE202434,GSE202438_13_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE211128_9_v_6_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null Epididymal epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.943 SOX4_01_140 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.62663 FE-10-KQ78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.85066 VENTX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1345 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.54376 corpus callosum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.21685 inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.958874 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MEC2 CCLE Cell Line Gene Expression Profiles 1.0 1.4584 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.71265 hsa-miR-4446-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GSE127790_4_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54666 Regulation of PLK1 Activity at G2/M Transition Reactome Pathways 2024 1.0 null PMC11985509-41467_2025_58704_MOESM7_ESM.xlsx-ZNF385A_vs_WT-Unnamed_1_ZNF385A Rummagene Transcription Factor Associations 2026 1.0 null chemdependency GAD High Level Gene-Disease Associations 1.0 0.293278 TBP ENCODE Transcription Factor Targets 1.0 null FOSL2 ENCODE Transcription Factor Targets 1.0 null Dynactin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.408 TAF1_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mitotic cell cycle process GO Biological Process Annotations 2015 1.0 null MCC13 COSMIC Cell Line Gene Mutation Profiles 1.0 null JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Crus II, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.5561 NCI-H2373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18638 SIN3B-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23883 disease of metabolism GWASdb SNP-Disease Associations 1.0 0.091694 lateral (dentate) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22982 GTEX-RWS6-2126-SM-2XCAV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21717 centriole COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.65874 trichostatin A-4436 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AIRE_KO_GDS2274_245_mouse_Medullary thymic epithelial cells (with low CD80 expression) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE193993_5_v_3_sstr2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE213588_10_v_7_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null sympathetic chain TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.338914 cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.255107 Dense fibrillar component COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.67 GSE234289_4_v_1_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null IC-76-JU42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.343399 intracellular non-membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null NCOR1 ENCODE Transcription Factor Targets 1.0 null GSE202744_1_v_3_toyocamycin_human RummaGEO Drug Perturbation Signatures -1.0 null CEBPB_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LNZTA3WT4 DepMap CRISPR Gene Dependency 1.0 2.80422 H3K27me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Polydactyly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.58 H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.96304 Ring centriole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.88 GSE48812_9_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GSE153867_6_v_4_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles 1.0 1.16362 GTEX-QVJO-1325-SM-2S1QX GTEx Tissue Sample Gene Expression Profiles 1.0 0.996518 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AC-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null moxisylyte-1846 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null splice GeneRIF Biological Term Annotations 1.0 null CRCGN017_MCF10A.WT.HP_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.3101 MKS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.149 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.972473 BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ciclopirox-6677 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cytoskeleton COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.532 ear TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.138068 cerebellar cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.36005 Alstrom syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RUSQ-1826-SM-2TF6E GTEx Tissue Sample Gene Expression Profiles 1.0 0.956216 cellular_component GO Cellular Component Annotations 2015 1.0 null Sarcoma_SARC_TCGA-DX-A3UA-01A-12R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null within GeneRIF Biological Term Annotations 1.0 null kinked sperm flagellum MPO Gene-Phenotype Associations 1.0 null Lobules IV-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66522 GSE95077_1_v_4_amiloride_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H2171 GDSC Cell Line Gene Expression Profiles 1.0 1.90438 YY1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Centriole COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 GSE221742,GSE221743_1_v_2_sipa1_human RummaGEO Gene Perturbation Signatures -1.0 null IX, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.911024 SKMEL1 CCLE Cell Line Gene Expression Profiles -1.0 -1.84647 FOXD4L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5105 YA-78-MS95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.294455 accumbens nucleus, shell domain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.44182 hacat HPA Cell Line Gene Expression Profiles 1.0 0.956641 Cell Cycle, Mitotic Reactome Pathways 2014 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5084-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE215109_0_v_2_ep400_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE154577_13_v_10_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE126463_4_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null KY821 GDSC Cell Line Gene Expression Profiles -1.0 -1.42474 cenexin1 GeneRIF Biological Term Annotations 1.0 null GSE205976,GSE205978_3_v_0_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null GSE229468,GSE229471_2_v_1_znf587_human RummaGEO Gene Perturbation Signatures -1.0 null mephentermine-3425 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE148193_1_v_0_satb2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HN-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE153867_6_v_3_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null plasma membrane bounded cell projection organization GO Biological Process Annotations 2025 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-3009-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null G-MEL COSMIC Cell Line Gene Mutation Profiles 1.0 null imatinib_homo sapiens_gpl96_gds3046 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null tetracycline-5757 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NNT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14913 H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-182 TargetScan Predicted Conserved microRNA Targets 1.0 0.248923 K562_GSK1070916_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0200933 GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.915089 GTEX-WEY5-0001-SM-3P61Z GTEx Tissue Sample Gene Expression Profiles 1.0 0.883773 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null TGFBR2_knockout_293_GSE46211 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.8654 CRCGN009_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.70687 PMC5047620__F6 PFOCR Pathway Figure Associations 2024 1.0 null cisplatin_mus musculus_gpl339_gds3099 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RAB3A MSigDB Cancer Gene Co-expression Modules 1.0 null bendroflumethiazide-3758 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SBNO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45307 substantia nigra, reticular part Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.836638 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null external cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06956 primidone-6723 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217452_2_v_1_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-4456 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GSE196699_7_v_3_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN015_MCF10A.TP53.M_24H:N02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14504 H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE125014_6_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08012 hsa-miR-4667-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 TXNDC12 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.83454 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE165647_5_v_3_cry2_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_Tranylcypromine_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0223774 POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17Z-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K23me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-877 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.868498 Diencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.043 sirolimus-1022 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE113817_0_v_1_bach1_human RummaGEO Gene Perturbation Signatures 1.0 null layer 1 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.38523 IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.27338 MAX_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Eyespot apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.806 JURL-MK1 COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null GSE211931_0_v_3_ncoa4_mouse RummaGEO Gene Perturbation Signatures -1.0 null MCF7_Barasertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0192323 H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MEIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.2281 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4727-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null 16,16-dimethylprostaglandin E2-6592 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null G141 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10133 tolbutamide-4540 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.684 CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02219 GSE156923_2_v_3_rbmx_human RummaGEO Gene Perturbation Signatures -1.0 null MCF7_Resveratrol_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0165235 GSE111385_2_v_3_tgfbr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null parvicellular part of Lat Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18972 Cell Cycle Reactome Pathways 2024 1.0 null 496100473_TCx_possible Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.68833 K562_Momelotinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150614 GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34633 GSE82032_3_v_1_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_UP_NR2F1_ind_UP-NR2F1_Ind_UP_NR2F1 Rummagene Transcription Factor Associations 2026 1.0 null striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31076 GTEX-X638-0326-SM-47JY1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25663 CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE208350_0_v_1_fgfr1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE211177,GSE211178_8_v_3_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null inclusion body COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.109995 Hypertrophy CTD Gene-Disease Associations 1.0 1.07732 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55E-2726-SM-48FCX GTEx Tissue Sample Gene Expression Profiles 1.0 1.42259 Embryonic carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.492 Sperm connecting piece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.715 ASPC1 CCLE Cell Line Gene Expression Profiles -1.0 -2.42775 OC-10-FB51_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.377248 Intercellular bridge COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.335 Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.01699 metformin-1816 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.79685 MAFK_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Centriolar satellite COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.823 Liver Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.52767 urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.060332 type ii diabetes mellitus GWASdb SNP-Phenotype Associations 1.0 0.537489 ciliary part GO Cellular Component Annotations 2015 1.0 null oculomotor nuclear complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.02456 Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE242290_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null H3K79me2_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128730_3_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN008_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.05765 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cilia GeneRIF Biological Term Annotations 1.0 null Simple lobule, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.01781 ZNF143 ENCODE Transcription Factor Targets 1.0 null X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.15056 ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.938049 GSE99187_1_v_0_gemcitabine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE226249_5_v_6_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null FF-86-NH56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.383765 CRCGN016_MCF10A.TP53.M_24H:D19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.29713 JURKAT BioGPS Cell Line Gene Expression Profiles 1.0 1.65043 hsa-miR-107 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 NKX1-1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23822 POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rhombomere 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59306 GTEX-R55D-0126-SM-48FEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.97758 hair cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.33744 SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null imatinib_homo sapiens_gpl96_gds3047 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1245 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 YD-49-HM53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.250025 Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34713 GSE209601_2_v_1_mef2a_human RummaGEO Gene Perturbation Signatures 1.0 null Varicose veins DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.726 OB-17-DQ74_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.413858 H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ventral striatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.57793 primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.9197 exocyst COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.24713 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K23me2_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RPS19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25714 pancuronium bromide-4570 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TBL1XR1 ENCODE Transcription Factor Targets 1.0 null cytoskeletal Phosphosite Textmining Biological Term Annotations 1.0 null Prostasome TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.275 hsa-miR-23a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.983747 Lateral cell cortex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.631 CRCGN011_HEPG2_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6664 Situs inversus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.591 GTEX-XQ8I-1926-SM-4BOOK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.877366 GSE118548_1_v_2_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE103068_5_v_1_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-8153-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null trachea TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.138827 Rootlet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.474 MCF7_Mesna_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0131421 OVTOKO CCLE Cell Line Gene Expression Profiles -1.0 -1.57815 SARS-CoV MA15_Day4-PFU-10^4_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.47131 GTEX-V1D1-2426-SM-3GAER GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00193 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050687 CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.916503 IZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -3.39001 H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE223008_5_v_2_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GABP MotifMap Predicted Transcription Factor Targets 1.0 null BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02965 shock Phosphosite Textmining Biological Term Annotations 1.0 null CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTA3 ENCODE Transcription Factor Targets 1.0 null Bicalutamide_HS-578T Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0108451 Sperm midpiece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.755 STAT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.5792 GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Microtubule end COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.312 chloramphenicol-5047 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE190555,GSE190557_2_v_3_chd4_human RummaGEO Gene Perturbation Signatures 1.0 null cellular component organization GO Biological Process Annotations 2015 1.0 null ETS1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Outer dense fibre protein 2-related InterPro Predicted Protein Domain Annotations 1.0 null cobalt chloride-454 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hsa-miR-548c-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 hela-cells Phosphosite Textmining Biological Term Annotations 1.0 null USF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6825 outer CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.956982 probenecid-4771 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null KYSE-150 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.824849 FF-28-ES17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.936955 1br3 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.319 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.827 CRCGN012_HEPG2_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0663 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10222 POLR2A_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8755441-mmc3.xlsx-IRF3-Up-IRF3-GM12878_IRF3 Rummagene Transcription Factor Associations 2026 1.0 null ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.11975 MCF7_Rigosertib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0226011 GTEX-RU72-1326-SM-2TF6T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26729 Lung squamous cell carcinoma_LUSC_TCGA-43-5668-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null indoprofen-4249 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-0002-SM-3NM8K GTEx Tissue Sample Gene Expression Profiles 1.0 0.969195 Distal tip TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.25 CCNT2 ENCODE Transcription Factor Targets 1.0 null ME-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.16855 GSE205976,GSE205978_2_v_4_cep83_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.959752 AN3 CA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.52735 KAT2B ENCODE Transcription Factor Targets 1.0 null SNRPA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28187 NCIH1793 CCLE Cell Line Gene CNV Profiles 1.0 1.49003 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pontine raphe nucleus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.20742 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Eye TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06669 Cytoplasmic microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.074 H3K4me1_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE234514,GSE234516_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null 3050_FDPS_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.511359 CTSK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03232 K562_Divalproex Sodium_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0370758 head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.873579 reduced male fertility MPO Gene-Phenotype Associations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4698-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.35383 HPBALL CCLE Cell Line Gene Expression Profiles 1.0 2.19537 L428 DepMap CRISPR Gene Dependency 1.0 10.5784 lateral septal nucleus, intermedio-dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15467 meclofenoxate-3405 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Centrosome COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.532 PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell projection COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.755437 Loss of proteins required for interphase microtubule organization from the centrosome Reactome Pathways 2024 1.0 null GSE156708_1_v_0_fbxo11_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.988673 dyclonine-7261 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.235 GTEX-T8EM-0126-SM-4DM5R GTEx Tissue Sample Gene Expression Profiles 1.0 1.89641 SUM225CWN Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.789501 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE131649_2_v_9_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null CREB1 ChEA Transcription Factor Targets 1.0 null allantoin-1800 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WVLH-3126-SM-3MJGA GTEx Tissue Sample Gene Expression Profiles 1.0 1.33231 EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-2625-SM-3LK77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.34124 Spindle microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.654 mature b-cell neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.323002 hsa-miR-4779 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21694 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC7585053__F3 PFOCR Pathway Figure Associations 2023 1.0 null CRCGN016_MCF10A.TP53.M_24H:A19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.04931 solasodine-3749 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Visceral heterotaxy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.561 MCF7_SRT3025 HCl_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0200648 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6366065-13075_2019_1816_MOESM1_ESM.xlsx-DOD_Skin_imputed_log2_median_ce-Name_PIN1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 1.65264 superficial stratum of SePal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49334 POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null chr9_128484897_C_T_b38 GTEx eQTL 2025 1.0 1.01125 LLC-PK1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.818 cytoskeleton Phosphosite Textmining Biological Term Annotations 1.0 null GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -2.18258 promazine-3752 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NFYA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE222445_2_v_1_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null Brain disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.073 S0-EE-Y737_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.257188 posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -3.25542 4star Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -2.16976 RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.62882 SMC1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.22822 POU2F2_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PEER CCLE Cell Line Gene CNV Profiles -1.0 -2.08522 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Joubert syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.896 HS819T CCLE Cell Line Gene Expression Profiles -1.0 -1.57293 CAPAN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.835535 GSE184399_0_v_3_cnot1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE216273,GSE216292_0_v_6_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null ZNF443 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28429 H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null protein binding GO Molecular Function Annotations 2015 1.0 null GTEX-XAJ8-1326-SM-47JYT GTEx Tissue Sample Gene Expression Profiles 1.0 2.49692 GSE69869_0_v_1_panobinostat_mouse RummaGEO Drug Perturbation Signatures -1.0 null Hexylresorcinol_SW 1271 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0146971 ARMCX6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4017 POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE197562_1_v_3_nox4_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.846409 GSE88819_1_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE184902_4_v_1_adiponectin_mouse RummaGEO Drug Perturbation Signatures -1.0 null Autosomal dominant nonsyndromic deafness 64 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.372 GTEX-N7MT-1226-SM-2D7W4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.895121 GSE135244_0_v_1_trdmt1_human RummaGEO Gene Perturbation Signatures -1.0 null SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal cell morphology MPO Gene-Phenotype Associations 1.0 null rosiglitazone_mus musculus_gpl7202_gse19896 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NOLC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12993 GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 1.52862 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null Primary autosomal recessive microcephaly 2 with or without cortical malformations DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.681 MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease GWASdb SNP-Disease Associations 1.0 0.024232 CRCGN008_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.44225 OCI-AML5 COSMIC Cell Line Gene Mutation Profiles 1.0 null Flemming body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.541 Nodulus (X) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22272 Paramedian lobule, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92037 GSE140651,GSE140653_2_v_6_med1_human RummaGEO Gene Perturbation Signatures -1.0 null CA-48-SW47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.507937 reduced male fertility MGI Mouse Phenotype Associations 2023 1.0 null GSE162575,GSE162609_3_v_2_tfe3_human RummaGEO Gene Perturbation Signatures 1.0 null MYCN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52333 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07518 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.736 pancreas HPA Tissue Gene Expression Profiles -1.0 -1.1257 PMC10591879-NIHMS1933918-supplement-2.xlsx-Down_in_NMR_OPC_differentiation-EGR1_EGR1 Rummagene Transcription Factor Associations 2026 1.0 null GSE128634,GSE128636_4_v_3_foxo1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE198165,GSE198166_9_v_1_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null ATF2 ENCODE Transcription Factor Targets 1.0 null GSE139540_0_v_2_menadione_human RummaGEO Drug Perturbation Signatures 1.0 null PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3 Rummagene Transcription Factor Associations 2026 1.0 null MCF7_Capecitabine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0144344 PMC6138936-13059_2018_1512_MOESM2_ESM.xlsx-SE_H1-_MSC-Gene-symbol_MSC Rummagene Transcription Factor Associations 2026 1.0 null FOXP2 ENCODE Transcription Factor Targets 1.0 null SUP-T1 GDSC Cell Line Gene Expression Profiles 1.0 1.51124 island of Calleja major Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5995 Paraflocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29908 10858_NON-TARGETING_NON-TARGETING Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.589625 MCF7_Temsirolimus_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0160124 roxarsone-5051 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-T5JC-2526-SM-4DM6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.40283 H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 15656903-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null cauda epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.641238 CRCGN009_HEPG2_24H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.7085 Culmen Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66522 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KP4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.91529 Rectum adenocarcinoma_READ_TCGA-DY-A1DF-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TALL-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00201 CRCGN009_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.15893 trim28_23493425_cd71pluster119plus_sorted_from_bone_marrow_lof_mouse_gpl6887_gse44063 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.220209 GSE136238_1_v_2_ebf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SMARCB1 ENCODE Transcription Factor Targets 1.0 null GSE235701,GSE261434_2_v_3_enasidenib_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-516a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A11A-11A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Crus I, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.967868 Lobule II Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30596 TET1-21490601-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null doxylamine-4819 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Sarcoma_SARC_TCGA-X6-A8C4-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Axonemal central apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.102 FOS::JUN JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.701 H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4894 TFAP2A JASPAR Predicted Transcription Factor Targets 1.0 null meclofenamic acid-2128 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null pallidum (globus pallidus complex) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07159 H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null all GWASdb SNP-Phenotype Associations 1.0 0.028395 17638893-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null H3K27ac_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lymphoid tissue TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02503 cellular component organization or biogenesis GO Biological Process Annotations 2015 1.0 null K562_Sodium Phenylbutyrate_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0264025 GATA2 ChEA Transcription Factor Targets 1.0 null corynanthine-4811 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Crus 2, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.92037 CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RU-01A-31R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null p95 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.53 CatSper complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.31 Burkitt lymphoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.506 Prestwick-983-7480 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-S7SE-0011-R11A-SM-2XCDD GTEx Tissue Sample Gene Expression Profiles 1.0 1.04465 Retinitis pigmentosa 28 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.029 Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5555-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Rutin (trihydrate)_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.011877 K562_Ki8751_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0210867 amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.79707 centrosome GeneRIF Biological Term Annotations 1.0 null AA-99-PN83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.352664 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Loss of proteins required for interphase microtubule organization from the centrosome Reactome Pathways 2014 1.0 null abnormal reproductive system physiology MPO Gene-Phenotype Associations 1.0 null 496100555_TCx_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.16243 substantia nigra reticulata, m1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28011 ELF1-20517297-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null MCF7_Mercaptopurine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0195764 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.996078 GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.850664 SUM102PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.32443 flavoxate-7405 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null KATOIII COSMIC Cell Line Gene Mutation Profiles 1.0 null Primary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.11 male reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.082021 GTEX-UPK5-1126-SM-3GAEJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.939048 INCENP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57197 hodf2 GeneRIF Biological Term Annotations 1.0 null MM127 DepMap CRISPR Gene Dependency 1.0 2.72075 GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25288 pyrimethamine-4194 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null intracellular non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-QDT8-0526-SM-3NMD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01213 glafenine-7257 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ME-31-RM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.384419 GSE200982_0_v_2_plac8_human RummaGEO Gene Perturbation Signatures 1.0 null CRCGN010_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.07093 H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE198165,GSE198166_5_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null Mitotic spindle pole body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.862 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6221-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_AR-42_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0127474 mepenzolate bromide-4304 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null FOXM1 ChEA Transcription Factor Targets 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3TX-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Folium-tuber vermis (VII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.24127 Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Clevudine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0261027 Weight Loss CTD Gene-Disease Associations 1.0 1.49019 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z4-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47211 GSE180641_0_v_1_zfp503_mouse RummaGEO Gene Perturbation Signatures 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Centrosome COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null Claustrum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35929 SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36905 H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A2780/R cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.574 CRCGN008_HEPG2_24H:L12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.0177 skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.27283 POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-1626-SM-32PLS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07836 GTEX-V955-1826-SM-4JBIL GTEx Tissue Sample Gene Expression Profiles 1.0 0.97307 GSE135030_8_v_10_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null 17150101-TableS1h GeneSigDB Published Gene Signatures 1.0 null ZBTB17 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.302 H4K20me1_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles 1.0 1.26154 Declive (VI) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70679 K562_Triamcinolone Acetonide_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0125335 TB-06-VB30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.272822 GSE192870_2_v_0_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null variantspecific GeneRIF Biological Term Annotations 1.0 null tobacco use disorder GAD Gene-Disease Associations 1.0 null GTEX-WFG7-0001-SM-3P61S GTEx Tissue Sample Gene Expression Profiles 1.0 1.33618 reproductive process GO Biological Process Annotations 2015 1.0 null ELAVL1 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-96 TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 atracurium besilate-1824 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Radial spoke stalk COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.848 multicellular organismal process GO Biological Process Annotations 2015 1.0 null brain_a HPA Tissue Sample Gene Expression Profiles -1.0 -0.876841 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A726-01A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sertoli cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.338 EP300 ENCODE Transcription Factor Targets 1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95886 Necrosis CTD Gene-Disease Associations 1.0 1.62713 CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSK3B Hub Proteins Protein-Protein Interactions 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HOP-92 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.884444 imatinib_homo sapiens_gpl96_gds3042 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell projection part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 hsa-miR-4721 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 CFPAC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.933807 H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MARK4 Pathway Commons Protein-Protein Interactions 1.0 null CEBPB_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN014_HEPG2_24H:B03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3687 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KLF5 JASPAR Predicted Transcription Factor Targets 1.0 null mebendazole-4694 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_TGX-221_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0330124 chr9_128449412_G_C_b38 GTEx eQTL 2025 1.0 1.43766 GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13922 MCF7_Ki16425_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0144046 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.49492 hsa-miR-3609 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 CFPAC1 CCLE Cell Line Gene CNV Profiles -1.0 -1.61542 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE140576_0_v_2_plag1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WL46-0626-SM-3LK7R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.91535 GSE228106_0_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_PF-573228_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146735 GTEX-XBED-0926-SM-48TCE GTEx Tissue Sample Gene Expression Profiles 1.0 0.833776 HEK-293FT cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.78 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ABL1_mutant_179_GSE45452 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.50834 GATA2_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Axonemal central pair COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.116 Septin cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.716 GSE111247_2_v_13_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null laticifer TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.297089 Mitotic spindle pole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.52 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.976445 Kinetochore microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.319 hsa-miR-4293 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.709576 CRCGN015_MCF10A.WT.HP_24H:F04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11051 CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34431 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARHGEF7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16422 NCI-H1781 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0491 spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.672506 GB-57-XV52_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.570663 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE205070_2_v_9_mertk_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE198165,GSE198166_6_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null SP4 ENCODE Transcription Factor Targets 1.0 null collaboration GeneRIF Biological Term Annotations 1.0 null GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00688 phosphoserine Phosphosite Textmining Biological Term Annotations 1.0 null Centrosome maturation Reactome Pathways 2024 1.0 null Prestwick-642-4594 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE159446,GSE159449_1_v_0_tunicamycin_mouse RummaGEO Drug Perturbation Signatures 1.0 null microtubule organizing center part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE182680,GSE182683_10_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null centrosome GO Cellular Component Annotations 2015 1.0 null medial ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.3747 EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM1A ENCODE Transcription Factor Targets 1.0 null K562_Cerdulatinib_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0139717 PLK1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.072002 NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.20569 N-acetylmuramic acid-1326 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.621 K562_GSK-LSD1 2HCl_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140028 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.503067 Joubert syndrome 23 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.191 BA-02-RI19_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249624 MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE236437_0_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures 1.0 null Purkinje cell layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.04875 GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13501 TRAPP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.661 A549_JNJ-26854165_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.013843 complete embryonic lethality before implantation MPO Gene-Phenotype Associations 1.0 null COPS4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9512 GTEX-QXCU-0008-SM-48FCH GTEx Tissue Sample Gene Expression Profiles 1.0 0.987864 GSE128634,GSE128636_1_v_3_foxo1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE247862,GSE247863_4_v_1_eomes_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_Fasudil_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0189671 JUND ENCODE Transcription Factor Targets 1.0 null HC-63-SV27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.356178 MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.386979 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-1470 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 PMC11237033-41419_2024_6873_MOESM3_ESM.xls-Supplementary_Appendix_2-MXD1_MXD1 Rummagene Transcription Factor Associations 2026 1.0 null SCC-25 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.4984 H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27546 MDAMB415 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.0654 CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1 ENCODE Transcription Factor Targets 1.0 null USF1_C2C12_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE113734_1_v_2_qprt_human RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null inferior olive, principal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.27056 NCI-H1651 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QLQW-1026-SM-447A9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.73879 GTEX-SSA3-0002-SM-3P61R GTEx Tissue Sample Gene Expression Profiles 1.0 0.897054 MCF7_Tozasertib_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144956 POLR2A_K562_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null cell cycle phase transition GO Biological Process Annotations 2015 1.0 null H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null K562_PF-3845_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154208 K562_Thiotepa_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0163264 MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18738 FOXM1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.76615 TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE195582_2_v_1_pim1_mouse RummaGEO Gene Perturbation Signatures -1.0 null RETREG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75341 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles 1.0 1.21799 Microtubule plus-end COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.982 COLO 800 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04132 GSE148263_6_v_9_trim3_human RummaGEO Gene Perturbation Signatures -1.0 null MK-886-264 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE75976_3_v_6_abl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE123638,GSE123639_2_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null YD-49-HM53_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.305302 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.46378 microtubule organizing center COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.23609 piriform cortex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.88969 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.14281 GSE126463_1_v_3_pomalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null SKMEL1 CCLE Cell Line Gene CNV Profiles -1.0 -1.65301 p3x63ag8.653 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.881 POLR2A ENCODE Transcription Factor Targets 1.0 null A549_BMS-911543_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157974 alvespimycin-4437 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE247084,GSE247087_0_v_1_cdyl_human RummaGEO Gene Perturbation Signatures 1.0 null Irf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.6398 Kidney BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.902126 imidurea-5062 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE127916_1_v_0_nras_human RummaGEO Gene Perturbation Signatures -1.0 null K562_Rigosertib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0273742 PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null MCF7_Fulvestrant_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00929284 CTCF_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null kinked sperm flagellum MGI Mouse Phenotype Associations 2023 1.0 null GSE203308_14_v_0_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 4651_LRP8_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.875439 MCF7_Tanespimycin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0125373 bambuterol-5885 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 0173570-0000-3693 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null estradiol_homo sapiens_gpl570_gse5102 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.1013 temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.10975 GTEX-T2IS-3126-SM-32QPK GTEx Tissue Sample Gene Expression Profiles 1.0 1.39313 amygdaloid complex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09791 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.910453 H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null SAP30 ENCODE Transcription Factor Targets 1.0 null cell part LOCATE Curated Protein Localization Annotations 1.0 null GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19297 Primary somatosensory area, nose Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0136 Nucleus of the lateral lemniscus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15041 Y-shaped link COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.205 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08012 GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.987557 GSE109530,GSE109531_1_v_0_hdac3_mouse RummaGEO Gene Perturbation Signatures 1.0 null LC-12-VN85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.557688 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.3981 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE234340_9_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null flunarizine-7252 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SIRT6 ENCODE Transcription Factor Targets 1.0 null Spermatogenic failure DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.587 GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01817 CRCGN015_MCF10A.TP53.M_24H:L15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3263 GSE140441_2_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WWYW-0011-R11A-SM-3NB38 GTEx Tissue Sample Gene Expression Profiles 1.0 0.903617 Recruitment of mitotic centrosome proteins and complexes Reactome Pathways 2024 1.0 null GSE218060_7_v_0_decitabine_human RummaGEO Drug Perturbation Signatures -1.0 null FF-86-NH56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.51753 GSE138468_3_v_6_dyrk1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE137177_2_v_0_folic acid_mouse RummaGEO Drug Perturbation Signatures 1.0 null cterminal GeneRIF Biological Term Annotations 1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null posterior (caudal) superior temporal cortex (area 22c)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.88391 GSE160373_8_v_2_pparg_mouse RummaGEO Gene Perturbation Signatures 1.0 null SRF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cerebellar nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15514 A-Vietnam-1203-2004(H5N1)_2day-TNFRSF1BKO_None_GSE40792 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.71534 DBH_KO_GDS4324_362_mouse_Embryonic heart E10.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Radial spoke head COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.068 posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.838897 GSE103068_5_v_3_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null USF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null arl6 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.467 Male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.65 BICR 78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.43101 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HF-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryonic lethality MPO Gene-Phenotype Associations 1.0 null mouse GeneRIF Biological Term Annotations 1.0 null AB-97-BI36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.230184 zaprinast-3226 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GB-73-QS80_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.379927 CRCGN013_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.62829 GSE71468,GSE76476_2_v_3_rbfox1_human RummaGEO Gene Perturbation Signatures -1.0 null Organelle biogenesis and maintenance Reactome Pathways 2024 1.0 null KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.20031 Contractile ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.033 PMC6627782__F2 PFOCR Pathway Figure Associations 2024 1.0 null GSE169713,GSE169715_1_v_2_tert_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE133691_2_v_0_lgr5_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_Obatoclax Mesylate_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0135832 USF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R3RS-0526-SM-3GADG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20475 TE-15-RO34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.205891 GSE121809_1_v_0_fmr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MCF7_ZM 447439_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0148769 ketanserin-4995 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-RU1J-1726-SM-2TF5S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01177 SNU349 CCLE Cell Line Gene CNV Profiles -1.0 -1.52276 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7289-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EE-03-SG02_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.469805 GTEX-RU72-0011-R7A-SM-2TF5U GTEx Tissue Sample Gene Expression Profiles -1.0 -0.963543 GATA2_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE129858,GSE129859_1_v_3_robo1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE203308_14_v_5_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null OVTOKO CCLE Cell Line Gene CNV Profiles -1.0 -1.3624 NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.40882 Centrosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.631 noscapine-5851 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46065 testis_7d HPA Tissue Sample Gene Expression Profiles 1.0 2.3802 TAF1 Pathway Commons Protein-Protein Interactions 1.0 null nucleus COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70145 hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Wholebrain BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.03308 non-membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE162892_3_v_1_isox_human RummaGEO Drug Perturbation Signatures -1.0 null G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.995366 QA-07-KC40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.682394 Ciliary necklace COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.705 abnormal spermatogenesis MPO Gene-Phenotype Associations 1.0 null brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GSE107956,GSE107957_0_v_1_ythdf2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE139455_0_v_6_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RARA::RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1964 cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.15064 GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29709 K562_Bosutinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150595 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 19841744-TableS5 GeneSigDB Published Gene Signatures 1.0 null spindle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE223893_2_v_9_setd2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE111247_11_v_10_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.79513 IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.46399 CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Binding Site Profiles 1.0 null Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MCF7_ENMD-2076_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0147852 amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20619 Lung adenocarcinoma_LUAD_TCGA-91-6836-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Breast Neoplasms CTD Gene-Disease Associations 1.0 1.02003 NE-94-VE83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.547463 ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PN-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hirschsprung's disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.083 AC-28-RT00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.30275 microtubule GeneRIF Biological Term Annotations 1.0 null CRCGN016_MCF10A.TP53.M_24H:H19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21085 MCF7_Resminostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145528 GTEX-V1D1-2126-SM-4JBH4 GTEx Tissue Sample Gene Expression Profiles 1.0 2.04921 CF-65-GU65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.251782 Teratocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.399 K562_Entacapone_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0169159 Mitotic spindle microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.55 K562_AG-490_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0172341 PMC2263127-pone.0001816.s001.xls-E2F3_down_Bild-Symbol_E2F3 Rummagene Transcription Factor Associations 2026 1.0 null Nodulus (X), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13471 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null POU4F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.5768 GTEX-U4B1-0006-SM-3DB8E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871552 MCF7_PD98059_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150781 cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47211 imipenem-7294 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE176008_8_v_3_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-XGQ4-2026-SM-4AT6G GTEx Tissue Sample Gene Expression Profiles 1.0 1.91503 red nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.49644 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null asthenozoospermia MGI Mouse Phenotype Associations 2023 1.0 null CAL-72 COSMIC Cell Line Gene Mutation Profiles 1.0 null C33A DepMap CRISPR Gene Dependency 1.0 2.66328 Uterine Carcinosarcoma_UCS_TCGA-N8-A4PL-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null axonemal microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.575912 WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 5155877-6544 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01488 CTCF_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_Ivosidenib_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0143782 cortico-medial group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.104 KOPN8 CCLE Cell Line Gene Expression Profiles 1.0 1.50461 JSC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE80537_3_v_2_adhfe1_human RummaGEO Gene Perturbation Signatures -1.0 null MCF7 BioGPS Cell Line Gene Expression Profiles 1.0 1.0594 KDM5B ENCODE Transcription Factor Targets 1.0 null POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gustatory areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24569 K562_SRT3025 HCl_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0199622 POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ventral posterolateral nucleus of the thalamus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16768 GTEX-S95S-1126-SM-4B64E GTEx Tissue Sample Gene Expression Profiles 1.0 2.08767 GSE185519_4_v_5_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null A549_Ramelteon_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0124511 GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74151 GTEX-U3ZG-0001-SM-47JYF GTEx Tissue Sample Gene Expression Profiles 1.0 0.862685 OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00691 K562_Filgotinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158686 PA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.864127 GSE202434,GSE202438_2_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null A549_Triamcinolone Acetonide_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00913502 internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.940066 GTEX-XMD1-2826-SM-4AT5F GTEx Tissue Sample Gene Expression Profiles 1.0 0.985322 OVTOKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.85534 GSE199606_3_v_4_ricin_mouse RummaGEO Drug Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.862712 t-cell chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null K562_Avagacestat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155189 Primary somatosensory area, trunk, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3331 H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31384 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.41234 GSE224096_3_v_0_cocaine_human RummaGEO Drug Perturbation Signatures -1.0 null SCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20567 GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.08168 NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null Spindle pole body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.208 PMC6627782__F2 PFOCR Pathway Figure Associations 2023 1.0 null GSE178340_7_v_4_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null Uridine_RKO Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00971345 GSE186287_1_v_3_ufm1_human RummaGEO Gene Perturbation Signatures -1.0 null SRF JASPAR Predicted Transcription Factor Targets 1.0 null CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3142 POLR2AphosphoS5_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A85H-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COLO 741 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null MCF7_Resveratrol_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0142518 U20S BioGPS Cell Line Gene Expression Profiles 1.0 1.08123 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE152441,GSE152442_7_v_5_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null ERF::SREBF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6344 Leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN016_MCF10A.TP53.M_24H:M14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.94758 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549_GSK J1_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0189172 H3K27me3_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null blood TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null centriole COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 bacterial infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042427 gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE119978,GSE180930_3_v_7_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null cisplatin_mus musculus_gpl339_gse6206 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null TBX19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29403 bed nucleus of stria terminalis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.883345 GSE164884_2_v_3_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null isoxicam-1820 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TCFCP2L1-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null SIN3A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleolar part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.251114 TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WZTO-1326-SM-3NM8X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.83352 female reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 CTCF_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SKMEL2 BioGPS Cell Line Gene Expression Profiles -1.0 -1.03565 TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tranilast_SW 1088 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.012454 SRF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K20me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Cediranib_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.01905 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5096-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE228181_2_v_1_idh1_mouse RummaGEO Gene Perturbation Signatures 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.076694 MHH-PREB-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-98-A53A-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.32753 Econazole_BT-474 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0060687 H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null abnormal sperm midpiece morphology MGI Mouse Phenotype Associations 2023 1.0 null FOSB::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.8282 KLM1 CCLE Cell Line Gene Expression Profiles 1.0 2.00446 cdc2dependent GeneRIF Biological Term Annotations 1.0 null GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74164 GTEX-T6MO-0003-SM-3NMAG GTEx Tissue Sample Gene Expression Profiles 1.0 1.07049 Sperm midpiece COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NR2C1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7399 FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RARA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.1601 MCF7_TAK-901_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0159579 microtubule organizing center part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.60418 GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -3.06014 cytoskeletal part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.65345 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null 6611_PPAT_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.531149 Prostate adenocarcinoma_PRAD_TCGA-EJ-A46G-01A-31R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Oligospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.423 meticrane-1671 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-Q2AH-1526-SM-48TZG GTEx Tissue Sample Gene Expression Profiles 1.0 1.81857 K562_Andarine_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0182316 K562_Nintedanib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149246 K562_INO-1001_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0170079 Lung adenocarcinoma_LUAD_TCGA-L4-A4E5-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR2F2 ENCODE Transcription Factor Targets 1.0 null CDC123 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.116 SIG-M5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.929829 Kinociliary basal body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.933 Carcinoma, Hepatocellular CTD Gene-Disease Associations 1.0 1.57522 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intermediate (interpositus) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13934 GSE198165,GSE198166_8_v_4_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE131649_2_v_7_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null WRNIP1 ENCODE Transcription Factor Targets 1.0 null POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE111247_11_v_9_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null BCL3 ENCODE Transcription Factor Targets 1.0 null CRCGN009_HEPG2_24H:L08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -4.4368 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.327205 alfaxalone-3135 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null macromolecular complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CEBPB_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PANC0403 CCLE Cell Line Gene Expression Profiles -1.0 -1.49472 GTEX-X4EP-3226-SM-3P5YR GTEx Tissue Sample Gene Expression Profiles 1.0 1.3934 MCF7_Vandetanib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0205833 ELK1-19687146-Hela cells-human ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-RWS6-0726-SM-47JXI GTEx Tissue Sample Gene Expression Profiles 1.0 0.860608 RCOR1 ENCODE Transcription Factor Targets 1.0 null organelle organization GO Biological Process Annotations 2015 1.0 null recruitment Phosphosite Textmining Biological Term Annotations 1.0 null abnormality of carbohydrate metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.187426 POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal cilium morphology MPO Gene-Phenotype Associations 1.0 null H3K27ac_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE188458_2_v_1_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures -1.0 null AD-86-OB87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.34984 CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE128634,GSE128636_2_v_5_foxo1_human RummaGEO Gene Perturbation Signatures -1.0 null CEBPB_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21124 GSE197555_0_v_2_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null Recycling endosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.641 K562_Pelitinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0152946 CRCGN013_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3162 NCVADR RES BioGPS Cell Line Gene Expression Profiles -1.0 -1.52554 bladder TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.071513 GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3811 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null allantoin-1842 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GB-69-YC71_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.226712 GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05792 PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21491 skmel30 HPA Cell Line Gene Expression Profiles -1.0 -1.85323 crucial GeneRIF Biological Term Annotations 1.0 null Retinal degeneration DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.354 MCF7_Baricitinib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0165371 NR2F2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCAR-4 GDSC Cell Line Gene Expression Profiles -1.0 -1.49147 Bladder Urothelial Carcinoma_BLCA_TCGA-H4-A2HQ-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7IS-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE236454,GSE236456_0_v_1_angiotensin ii_mouse RummaGEO Drug Perturbation Signatures 1.0 null DAOY CCLE Cell Line Gene Expression Profiles 1.0 1.59551 10623_ZNF774_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.572928 EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.758 Intraciliary transport particle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.489 reproductive system phenotype MPO Gene-Phenotype Associations 1.0 null Uridine_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0338807 GSE211177,GSE211178_0_v_1_ets1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE180200,GSE180201_15_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PSDG-0426-SM-2S1OF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.824593 Vegetative cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.774 GTEX-UPK5-0003-SM-3NMDI GTEx Tissue Sample Gene Expression Profiles 1.0 0.887015 GSE128634,GSE128636_2_v_3_foxo1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE139239_2_v_6_ddr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null lymphnode_5a HPA Tissue Sample Gene Expression Profiles 1.0 0.890094 MCF7_SNS-314 Mesylate_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0194487 H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_AC480_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0187993 GSE182680,GSE182683_0_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE209598_0_v_3_tgfbr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acrosomal matrix COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.764 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pyramus (VIII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62064 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.366 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21893 GSE184892_7_v_5_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null cyclizine-1731 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MCF7_Lomustine_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0142837 RUNX3 ENCODE Transcription Factor Targets 1.0 null GSE181003_1_v_2_selinexor_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_UP_AA_UP-AA_UP_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null mafenide-2287 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC5651844-41467_2017_1173_MOESM5_ESM.xlsx-Down_genes_shY2-1-Supplementary_Data_1_Down_regulated_genes_in_ShY2_KD_cells_AR Rummagene Transcription Factor Associations 2026 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H4K20me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2908-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null betonicine-2207 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null IPC-298 COSMIC Cell Line Gene Mutation Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PE-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hTERT-RPE1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.345 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.916296 GSE206270_1_v_0_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null acetazolamide-1850 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2AphosphoS5_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 TTC642 DepMap CRISPR Gene Dependency 1.0 4.68809 JHH-6 COSMIC Cell Line Gene Mutation Profiles 1.0 null rat GeneRIF Biological Term Annotations 1.0 null GSE142210_9_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null NFIX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.76153 JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.5443 TEAD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.401 CRCGN017_MCF10A.WT.HP_24H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.8228 HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.93844 K562_PD173074_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0187488 ethambutol-4120 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null abnormal sperm midpiece morphology MPO Gene-Phenotype Associations 1.0 null Outer dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.349 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041537 CEBPB_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial (main) part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10316 GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18039 Stat2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 102.594 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LASP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58551 CC-68-YZ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.291647 septopallidal part of the olfactory tuberculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48055 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null josamycin-5692 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RPP38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10728 intermediate stratum of r2Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04238 monocrotaline-7127 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-X4EP-0726-SM-3P5YJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.879004 sperm flagellum GO Cellular Component Annotations 2025 1.0 null GSE112962,GSE112963_2_v_1_ddx5_human RummaGEO Gene Perturbation Signatures -1.0 null YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null centrosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 anchoring GeneRIF Biological Term Annotations 1.0 null CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.982386 GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58829 GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12787 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4C9-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-23c TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GTEX-R55F-1226-SM-2TF59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09138 HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.49249 8165_SMG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.50039 GSE208350_4_v_1_fgfr1_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE71468,GSE76476_0_v_3_rbfox1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE162739_2_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE71385_1_v_0_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X638-0003-SM-47JZ1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01826 PMC7429792-40104_2020_487_MOESM3_ESM.xlsx-MSC_enriched_miRNA_target-NAME_MSC Rummagene Transcription Factor Associations 2026 1.0 null HT-115 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.31443 TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.18833 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.40937 POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MHH-ES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25884 Hematopoietic cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 B4GALNT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13233 single-organism developmental process GO Biological Process Annotations 2015 1.0 null FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null triamterene-1861 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Baboon_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7B4-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IHF-DNA complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.575 CRCGN015_MCF10A_48H:D24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.11673 facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.30163 MCF7_TGX-221_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0182181 H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of the PBC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06064 GTEX-XUW1-1826-SM-4BOQD GTEx Tissue Sample Gene Expression Profiles 1.0 0.915524 Rectum adenocarcinoma_READ_TCGA-F5-6814-01A-31R-1928-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null colistin-4796 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.936424 Lingula (I), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17316 Type 2 diabetes mellitus_Pancreas_GSE2470 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.04336 hsa-miR-377 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.14533 GSE247764_5_v_2_nell2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Spermary TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.888 SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.958084 benzathine benzylpenicillin-2939 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null testis TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 polycystic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.417644 artemisinin-7247 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE225735_1_v_4_aldosterone_human RummaGEO Drug Perturbation Signatures 1.0 null cerebellar cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.42276 H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5876-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ornidazole-2109 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-R55F-1526-SM-2TF4X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0642 NCI-H1915 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.59154 Inflammation CTD Gene-Disease Associations 1.0 1.47966 Scrotum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.171 CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-0008-SM-47JYX GTEx Tissue Sample Gene Expression Profiles 1.0 1.20183 GTEX-S7SE-0326-SM-4AT5Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.76766 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213611_1_v_0_nuf2_human RummaGEO Gene Perturbation Signatures 1.0 null NCI-H460 GDSC Cell Line Gene Expression Profiles -1.0 -1.67775 deptropine-3144 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SNAI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.6688 PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8 Rummagene Transcription Factor Associations 2026 1.0 null A549_CUDC-101_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154027 cell cycle GO Biological Process Annotations 2015 1.0 null Meier-Gorlin syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.008 GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26508 GTEX-OXRO-1926-SM-2S1O3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.894172 GSE144231_3_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239844_4_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.2517 Lung squamous cell carcinoma_LUSC_TCGA-34-5927-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 nordihydroguaiaretic acid-1223 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-NL3H-0011-R4a-SM-2I3GK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.911187 GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00529 GSE114992,GSE114993_7_v_2_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null K562_Costunolide_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0235807 THAP1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Radial spoke COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.4 Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-8502-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE116930,GSE116935_3_v_6_hes7_human RummaGEO Gene Perturbation Signatures -1.0 null IV, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.24191 Flocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38826 SR-95531-4820 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.32907 Microtubule organizing center COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 1.0 1.532 3537_GRINA_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.505722 GSE162892_3_v_0_sox9_human RummaGEO Gene Perturbation Signatures -1.0 null Mitochondrial cloud COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.84 U266B1 CCLE Cell Line Gene CNV Profiles 1.0 1.4478 TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE145476_2_v_0_hopx_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51769 extension GeneRIF Biological Term Annotations 1.0 null hsa-miR-103a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 abnormal sperm flagellum morphology MPO Gene-Phenotype Associations 1.0 null Orofaciodigital syndrome IX DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.53 POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PP-0326-SM-33HC4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.878911 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13034 CRCGN016_MCF10A.TP53.M_24H:H10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9892 NCI-H2171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.60721 POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 10407_ZNF510_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.514621 VIIB, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.975803 caudal ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.17074 K562_Decitabine_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.016298 Nodulus (X), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28277 KP-N-RT-BM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.758 GSE160442,GSE160444_1_v_0_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null LoVo GDSC Cell Line Gene Expression Profiles -1.0 -1.90279 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21606 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.22787 amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.30198 EB-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.795 GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91462 inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.960882 AA-22-UI44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.627748 plexiform layer of TuStr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27602 PMC6053425-41467_2018_5258_MOESM20_ESM.xlsx-DREAM_MMBFoxM1_targets-Fischer_M_et_al_Nucleic_Acids_Res_2016_KCNIP3 Rummagene Transcription Factor Associations 2026 1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null GTEX-OXRO-0011-R10A-SM-2I5EH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.975935 GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09876 uterus BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.86665 GSE152441,GSE152442_6_v_2_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null NR2F6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.4441 SHP-77 GDSC Cell Line Gene Expression Profiles 1.0 2.00756 GSE223008_6_v_3_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE176008_8_v_5_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null TFCP2L1 ChEA Transcription Factor Targets 1.0 null H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gustatory areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20467 prostate adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.65763 indapamide-4335 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RXRA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRDM14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02002 GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.14863 H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null components GeneRIF Biological Term Annotations 1.0 null Infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.095 YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE198165,GSE198166_6_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null Purkinje cell layer of CbVCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38331 GSE184399_0_v_2_cnot1_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-600 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.889901 RFX5 ENCODE Transcription Factor Targets 1.0 null GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37058 GSE220097_4_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Microcephaly DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.525 Neurosphere_Cultured_Cells_Ganglionic_Eminence_Derived Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.849209 GSE239844_11_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null K562_AMG-900_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0196691 GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.918037 MCF7_Quisinostat_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00614992 GSE131649_2_v_1_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC8020666-pnas.2015855118.sd11.xlsx-LPS_attenuatedResponse-Unnamed_13_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Crus II, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.951695 mRNA_KLF4_18264089 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null procaine-6329 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_ABT-737_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0188346 9971_ZBTB14_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.597766 MCF7_Capecitabine_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0283126 FF-34-KW62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.335165 CRCGN015_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.06075 HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.11001 nucleus GO Cellular Component Annotations 2015 1.0 null GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71146 CAMA1 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.582905 endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 USF1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.87963 GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -2.00342 ECD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09736 COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.882913 GSE211177,GSE211178_9_v_1_ets1_mouse RummaGEO Gene Perturbation Signatures -1.0 null isoflupredone-1832 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PANC 03.27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.82795 cefotaxime-1389 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me1_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.953888 Potassium Dichromate CTD Gene-Chemical Interactions 1.0 null GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16937 GSE111247_0_v_8_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE248045,GSE248046_6_v_5_runx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null TEAD4-22529382-TROPHECTODERM-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null KAT2A ENCODE Transcription Factor Targets 1.0 null MCF7_Quercetin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0196113 TRO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48168 BB-75-UH54_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.349343 bronchoalveolar system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061535 PMC3738137-bjc2013359x6.pdf-4-TRPS1_TRPS1 Rummagene Transcription Factor Associations 2026 1.0 null eGFP-FOS_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216238,GSE216241_0_v_1_tonsl_human RummaGEO Gene Perturbation Signatures 1.0 null MCF7_JNJ-26854165_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0131787 MCF7_Triamcinolone Acetonide_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0100916 Prostate adenocarcinoma_PRAD_TCGA-VP-A87D-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CUX1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pyramidal layer of taenia tecta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14168 NCIH1581 CCLE Cell Line Gene CNV Profiles -1.0 -1.54547 cell cycle g2/m phase transition GO Biological Process Annotations 2015 1.0 null CRCGN015_MCF10A.WT.HP_24H:O12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.29336 Sperm glycocalyx COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.787 GSE119978,GSE180930_3_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91541 hsa-miR-548ah TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Secondary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.017 Brain Lower Grade Glioma_LGG_TCGA-FG-A87N-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 496100417_HIP_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.35839 hippocampus (hippocampal formation)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.991967 SNU-398 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.846409 hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.83042 H3K9ac_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A681-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JAK2_druginhibition_168_GSE38335 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.24304 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCB000038-7542 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.WT.HP_24H:F13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.32861 superficial stratum of r7BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09414 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal gametes MPO Gene-Phenotype Associations 1.0 null ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LS-411N GDSC Cell Line Gene Expression Profiles -1.0 -2.55482 EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.317954 tropicamide-3722 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AB-71-CI37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.203617 UBTF_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1 Rummagene Transcription Factor Associations 2026 1.0 null CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null HOP92 BioGPS Cell Line Gene Expression Profiles -1.0 -0.878068 K562_AR-42_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0180061 GSE227592_4_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null H3K79me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HOXD12::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.522 CRCGN014_HEPG2_24H:J15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -3.16455 CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7155-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Selisistat_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0190243 cellular process involved in reproduction in multicellular organism GO Biological Process Annotations 2015 1.0 null GTEX-RNOR-2426-SM-48FDY GTEx Tissue Sample Gene Expression Profiles 1.0 1.3327 cilium COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE135030_8_v_1_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHU029 DepMap CRISPR Gene Dependency 1.0 3.29754 CRCGN017_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.30315 K562_Daphnetin_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.016605 ELF1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null head TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054187 atracurium besilate-1702 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE178340_5_v_4_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null bepridil-2629 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null A549_UNC0631_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0149937 central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.31919 GSE201381_0_v_1_bhlhe22_mouse RummaGEO Gene Perturbation Signatures -1.0 null trifluridine-3559 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null foxa1_23539448_lncap_lof_human_gpl10558_gse37314 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.772657 POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153867_6_v_8_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JA-26-YQ32_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.25021 PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-458-MAFF_MAFF Rummagene Transcription Factor Associations 2026 1.0 null NB69 DepMap CRISPR Gene Dependency 1.0 3.97021 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.55817 hsa-miR-135a TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 M Phase Reactome Pathways 2024 1.0 null appendages GeneRIF Biological Term Annotations 1.0 null GSE245134_2_v_3_atg5_mouse RummaGEO Gene Perturbation Signatures 1.0 null Rectal Mucosa Donor 31 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.04326 GSE196505,GSE196507_3_v_2_kdm2b_human RummaGEO Gene Perturbation Signatures 1.0 null REST ENCODE Transcription Factor Targets 1.0 null AJUBA Pathway Commons Protein-Protein Interactions 1.0 null SKGT4 DepMap CRISPR Gene Dependency 1.0 4.31464 Megacolon DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.022 GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00725 Retinal pigment epithelium cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.92 CTCF_MEL cell line_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV_48Hour_20090954_GSE17400 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.48858 K562_CYC116_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0260459 intracellular COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.340017 H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cerebellar nuclei of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17743 ZNF263 ENCODE Transcription Factor Targets 1.0 null POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BC-56-BB82_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.364142 testis_7e HPA Tissue Sample Gene Expression Profiles 1.0 2.00389 Semen TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.373 GSE111247_0_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13368 GSE58724_3_v_0_oxymetholone_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE171837_0_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null Placenta TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.025 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nuclear MIS12/MIND complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.753 GTEX-OHPK-2026-SM-3MJH7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13197 Centriolar subdistal appendage COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 KE-37 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.525 lower (caudal) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.827719 COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20731 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SIN3A ChEA Transcription Factor Targets 1.0 null dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.899602 PMC7585053__F3 PFOCR Pathway Figure Associations 2024 1.0 null Microtubule cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GSE119345_2_v_4_bexarotene_human RummaGEO Drug Perturbation Signatures 1.0 null MCF7_Daphnetin_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0152877 whose GeneRIF Biological Term Annotations 1.0 null POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9314667-Table_1.xlsx-Regulons-JUN_JUN Rummagene Transcription Factor Associations 2026 1.0 null MCF7_A-366_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0142332 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T6-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Tucidinostat_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0238305 OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06457 GSE169205_0_v_8_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null Blastocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.896 Microtubule minus-end COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.23 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ciliary basal body COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE181749_0_v_1_cisplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Prestwick-860-3378 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null paraterminal gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19879 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CQ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BD-33-HT38_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.239793 PMC3573729-nl3042917_si_005.xlsx-OWY_Overlap_with_ANOVA-ORKIN_E2F1_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Sense organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.863977 axoneme COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ELF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null nasopharynx HPA Tissue Protein Expression Profiles 1.0 1.3096 Ciliary cap COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.169 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null spironolactone-5781 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-X261-0011-R6B-SM-4E3J8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.884671 GSE131649_6_v_1_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X4XY-0526-SM-46MW1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.87724 abnormal germ cell morphology MPO Gene-Phenotype Associations 1.0 null H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null amygdaloid complex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.985557 SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-57-XV52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.735329 YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null stat3_00000000_a549_lof_human_gpl571_gse42979 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.057519 SNU840 DepMap CRISPR Gene Dependency 1.0 2.53947 CRCGN015_MCF10A.TP53.M_24H:G21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15055 Gustatory areas, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4515 Autosomal recessive disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.591 JHOS4 CCLE Cell Line Gene CNV Profiles -1.0 -1.34768 CTCF_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.04 GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60267 GSE62974_1_v_0_epas1_mouse RummaGEO Gene Perturbation Signatures 1.0 null mcf7 HPA Cell Line Gene Expression Profiles 1.0 1.80173 TCCSUP COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE193402_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9 Rummagene Transcription Factor Associations 2026 1.0 null MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Aurora A Inhibitor I_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0250303 SLC35E4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.50703 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YI-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null centriolar GeneRIF Biological Term Annotations 1.0 null COT Kinase Library Serine Threonine Kinome Atlas 1.0 null GSE135439_0_v_1_pax5_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43621 GLI1 MotifMap Predicted Transcription Factor Targets 1.0 null FOXF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32412 diethylstilbestrol-3429 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72435 MCF7_Lapatinib_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0130688 GTEX-WCDI-0002-SM-3P61U GTEx Tissue Sample Gene Expression Profiles 1.0 0.915762 GSE139455_0_v_3_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null Atazanavir (sulfate)_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0236753 GSE125782_0_v_2_glutamine_mouse RummaGEO Drug Perturbation Signatures 1.0 null lateral parabrachial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07002 GTEX-OXRO-0011-R2A-SM-3NB1W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05637 GTEX-OHPN-2726-SM-2I5H4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.886065 superficial stratum of Pal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.85826 microtubule cytoskeleton COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CRCGN009_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.18567 lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.43451 H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cell projection part GO Cellular Component Annotations 2015 1.0 null GSE66014_0_v_1_perhexiline_human RummaGEO Drug Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-06A-22R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOS::JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.7957 GSE144231_6_v_5_cxcr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-8144-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN008_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.83395 15260889-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.3142 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2471 PPARD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8108 MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null VIIIA, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41226 GSE139348,GSE139349_1_v_0_dicer1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Sperm head-tail coupling apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.243 r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62272 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.41805 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NR-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A8BH-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RC-K8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.70333 riboflavin-2760 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null CRCGN010_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1272 Condensed chromosome, centromeric region COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.562 A549_Cimetidine_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0266079 secondary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.198566 Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 KAT2B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CALU-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.968181 Eye degenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.349 REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31299 Yy1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.0057 H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Stellate ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.858 GSE169356_0_v_3_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null Cortical amygdalar area, anterior part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48132 POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN013_HEPG2_24H:K17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17373 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS822T CCLE Cell Line Gene Expression Profiles -1.0 -1.70126 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Follicular fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.867 USF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-0011-R11A-SM-2HMJS GTEx Tissue Sample Gene Expression Profiles 1.0 1.28912 dorsal peduncular cortex, intermediate part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26486 GSE102505_6_v_2_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AG-0011-R9A-SM-2HMJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07506 MAZ ENCODE Transcription Factor Targets 1.0 null vestibular system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.172921 GTEX-T5JC-0011-R11A-SM-32PMB GTEx Tissue Sample Gene Expression Profiles 1.0 1.06631 GSE193258,GSE193259_9_v_3_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158632_3_v_5_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 1.48595 T-cell chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 K562_PF-573228_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0184796 FE-10-KQ78_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.386224 CP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.66651 JEKO1 CCLE Cell Line Gene Expression Profiles 1.0 1.63987 9+2 motile cilium GO Cellular Component Annotations 2025 1.0 null H3K9me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSU DepMap CRISPR Gene Dependency 1.0 4.48841 A549_Busulfan_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0150709 GTEX-T6MN-0011-R11A-SM-32QOX GTEx Tissue Sample Gene Expression Profiles 1.0 1.27428 TB-06-VB30_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.242321 posterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22041 spleen BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.27762 GSE160817_5_v_6_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null FLI1 ChEA Transcription Factor Targets 1.0 null CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.991044 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.81824 diabetes mellitus GWASdb SNP-Phenotype Associations 1.0 0.284431 SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.973505 CDK1 PhosphoSitePlus Substrates of Kinases 1.0 null K562_JNJ-7706621_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.018458 UM-UC-3 GDSC Cell Line Gene Expression Profiles -1.0 -1.60452 pyramidal layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.881546 GSE143643,GSE143644_3_v_5_hdac3_mouse RummaGEO Gene Perturbation Signatures 1.0 null HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20567 CTCF_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Regulation of PLK1 Activity at G2/M Transition Reactome Pathways 2014 1.0 null GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 1.50382 USF1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210682_0_v_3_methadone_human RummaGEO Drug Perturbation Signatures -1.0 null QF-71-QI30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220712 GSE198826,GSE198911_1_v_2_dexamethasone_mouse RummaGEO Drug Perturbation Signatures 1.0 null PTEN_KD_GDS2958_99_human_A431 - EPIDERMOID carcinoma cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null picrotoxinin-4842 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Supraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20829 esculin-3390 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ambroxol-6719 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE233679_12_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE148262,GSE150691_3_v_2_hdlbp_human RummaGEO Gene Perturbation Signatures -1.0 null GSE202933_1_v_0_ugt2b28_human RummaGEO Gene Perturbation Signatures -1.0 null primary motor cortex (area M1, area 4)_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.04558 salivarygland_6b HPA Tissue Sample Gene Expression Profiles -1.0 -0.922105 GSE166920_6_v_4_adalimumab_human RummaGEO Drug Perturbation Signatures -1.0 null 5194442-6558 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042895 YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null liver_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.07822 dorsolateral part of Lat Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25966 picotamide-7140 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-S7SF-0006-SM-3K2B6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16303 GSE57871_1_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Spindle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.886 Nr1h3::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.1426 procainamide-5663 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MCF7_PD98059_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.020167 ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE246660_1_v_0_lmo3_human RummaGEO Gene Perturbation Signatures 1.0 null IRAK4_knockout_41_GSE12124 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.99075 GTEX-WL46-0011-R11A-SM-3MJFT GTEx Tissue Sample Gene Expression Profiles 1.0 0.979772 testicular cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.700671 SNU869 DepMap CRISPR Gene Dependency 1.0 4.05452 JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7588-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCF7_Divalproex Sodium_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0156046 phensuximide-2960 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MCF7_BMS-911543_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0153217 RXRA ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-5643-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-934 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04973 CRCGN012_HEPG2_24H:J19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.75007 Ewing's sarcoma_Renal Tissue_GSE1822 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.26798 an3ca HPA Cell Line Gene Expression Profiles 1.0 0.902908 Primary somatosensory area, nose, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02905 tardbp_19910924_hek293e_lof_human_gpl570_gds3730 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.286809 PTTG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1467 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.893247 GTEX-NPJ8-1426-SM-3MJHR GTEx Tissue Sample Gene Expression Profiles 1.0 1.42641 CRCGN016_MCF10A.WT.HP_24H:C11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3525 SKCO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.44554 GTEX-QDT8-0011-R11A-SM-32PKD GTEx Tissue Sample Gene Expression Profiles 1.0 0.951789 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NL-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE103068_0_v_3_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE256181_2_v_3_etv2_human RummaGEO Gene Perturbation Signatures -1.0 null CRCGN017_MCF10A.TP53.M_24H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.08351 U2AF2_02_105 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59909 nitrofurantoin-3674 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H1155 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.28238 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.828492 Liver hepatocellular carcinoma_LIHC_TCGA-CC-5263-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.98536 GSE252988_0_v_1_lefamulin_human RummaGEO Drug Perturbation Signatures -1.0 null Agranular insular area, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28069 Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.127 GSE102505_6_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE145639_7_v_4_adar_human RummaGEO Gene Perturbation Signatures -1.0 null K562_Fasudil_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0209045 PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-327-NR1H4_NR1H4 Rummagene Transcription Factor Associations 2026 1.0 null PMC4384327-12859_2014_432_MOESM6_ESM.pdf-2-DNMT1_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cefazolin-3426 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE201309_5_v_3_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null SRF ENCODE Transcription Factor Targets 1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE206270_2_v_0_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null benserazide-6722 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null alfadolone-7262 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null EP300_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.944849 Microtubule organizing center COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.68 anterior nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08444 nimesulide-2112 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RARG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6162 Cilium Assembly Reactome Pathways 2024 1.0 null H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Spermatozoon TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.442 centriole GO Cellular Component Annotations 2015 1.0 null sense organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4427-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -2.9262 FD-20-OG99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.604091 retroparafascicular area of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.95102 Parabrachial nucleus, lateral division, external lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01417 GTEX-TML8-0001-SM-3NMAF GTEx Tissue Sample Gene Expression Profiles 1.0 1.11061 SLC25A24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25716 GSE88819_1_v_12_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Plasma membrane bounded cell projection cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.369 renal tubular acidosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.799923 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.96566 hsa-miR-483-3p TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 GSE111247_14_v_5_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.28743 H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.955003 LF-94-HB11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.400625 TAF1_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSK3B KEA Substrates of Kinases 1.0 null PMC11630641-mmc8.xlsx-Human_1000cell_NOT_identified-Unnamed_1_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null ChIP_MYCN_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null 17724462-TableS2 GeneSigDB Published Gene Signatures 1.0 null GSE162739_7_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH2347 CCLE Cell Line Gene Expression Profiles -1.0 -1.76274 GSE180200,GSE180201_2_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null Diethylstilbestrol CTD Gene-Chemical Interactions 1.0 null semen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.02118 GSE136742,GSE136744_0_v_3_setd2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Six4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.0424 V Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.926623 H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN017_MCF10A.WT.HP_24H:O08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0633 CC-04-WK34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.295089 PMC6400843-Table_5.xls-C_FOXM1_Correlated_genes-Ensembl_ID_FOXM1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H748 COSMIC Cell Line Gene Mutation Profiles 1.0 null FF-28-ES17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.44244 SW 1463 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.852548 BICR 78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.04241 NCI-H2052 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.842892 Anchoring of the basal body to the plasma membrane Reactome Pathways 2014 1.0 null CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Axonemal microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.964 norfloxacin-2090 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null COCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.94 HB-95-ZG66_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.296421 GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.889928 GSE226249_2_v_3_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null PMC4944136-srep28995-s2.xls-OTX2-gene_OTX2 Rummagene Transcription Factor Associations 2026 1.0 null DMS 273 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.846409 SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null K562_PJ34_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161091 GSE131649_6_v_5_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN015_MCF10A.WT.HP_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.64398 CCRT CEM BioGPS Cell Line Gene Expression Profiles 1.0 0.827344 GSE208634_1_v_0_doxycycline_human RummaGEO Drug Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.61642 CRCGN015_MCF10A.TP53.M_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.9754 CRCGN014_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3375 GSE169356_0_v_5_ivermectin_human RummaGEO Drug Perturbation Signatures -1.0 null cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Lung squamous cell carcinoma_LUSC_TCGA-85-8070-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Altretamine_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0198886 VIIB, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.927704 MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7536-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 18794137-SuppTable1b GeneSigDB Published Gene Signatures 1.0 null disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.041641 GSE161800_0_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.615 primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1098 6-azathymine-3987 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE144347_1_v_0_crnkl1_human RummaGEO Gene Perturbation Signatures -1.0 null efficiently GeneRIF Biological Term Annotations 1.0 null GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47964 cefoxitin-3477 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 20208059-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null hippocampus (hippocampal formation)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.06574 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.5803 GTEX-QEG4-0126-SM-48TZE GTEx Tissue Sample Gene Expression Profiles 1.0 3.00142 MCF7_Temsirolimus_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0161922 CRCGN016_MCF10A.TP53.M_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.3374 Entorhinal area, medial part, ventral zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38015 GTEX-XBED-2026-SM-4AT5D GTEx Tissue Sample Gene Expression Profiles 1.0 1.73653 GSE129244_3_v_5_lmo2_mouse RummaGEO Gene Perturbation Signatures 1.0 null EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG8-0626-SM-3GILJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.875892 Motile cilium COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Prostate adenocarcinoma_PRAD_TCGA-HC-A8CY-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.WT.HP_24H:I07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.23345 amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.22987 MCF7_Luminespib_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.00951015 GSE134375_6_v_5_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042893 PCI30 DepMap CRISPR Gene Dependency 1.0 2.55405 POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FGFR3_druginhibition_36_GDS5023 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.06514 GTEX-WZTO-3026-SM-3NMA2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18386 K562_Maraviroc_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0190264 NFATC1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.869342 GSE228106_3_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null sirolimus_mus musculus_gpl1261_gse5332 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE183606_1_v_0_rutaecarpine_human RummaGEO Drug Perturbation Signatures -1.0 null VZ in caudal cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.971868 MEWO COSMIC Cell Line Gene Mutation Profiles 1.0 null mantle zone of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3143 posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.908382 MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBED-1126-SM-48TCF GTEx Tissue Sample Gene Expression Profiles 1.0 0.944226 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3JW-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE216273,GSE216292_0_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null 9+0 motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.376 H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KCIMOH1 CCLE Cell Line Gene Expression Profiles -1.0 -1.71164 GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81693 sputum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.232039 GSE213588_9_v_6_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74568 CEBPB_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null trapidil-3136 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Zileuton_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0131562 GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44149 Lymphocyte TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Centriolar subdistal appendage COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.72 GSE118548_1_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null parabigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.828512 GSE143955_1_v_2_ripk1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H2122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.36905 BT-20 COSMIC Cell Line Gene Mutation Profiles 1.0 null 10719_ZSCAN25_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.53062 valproic acid_mus musculus_gpl1261_gds3002 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Frontal pole, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0021 GSE242367_1_v_0_dpp9_human RummaGEO Gene Perturbation Signatures -1.0 null PMC6858560-NIHMS1538530-supplement-Supplementary_Tables.xlsx-Supplementary_Table_21-Supplementary_Table_21_Aberrant_Splicing_Events_in_TET2_SRSF2_co-mutated_AML_Patients_from_the_TCGA_cohort_TET2 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN013_HEPG2_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.18849 TC32 CCLE Cell Line Gene Expression Profiles -1.0 -1.71409 H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 5 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0757 KNS-81-FD COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.83785 trunk TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052895 GSE165548_2_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ciliary transition fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.493 PMC8020666-pnas.2015855118.sd11.xlsx-LPS_strongerResponse-Unnamed_13_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE135352_0_v_1_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null Spine apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.04 dorsolateral part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16221 ASXL1-24218140-BMDM-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFYA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null galantamine-4186 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Cerebellum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59971 MXI1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040115 oxetacaine-4829 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cochlea TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.213112 CRCGN015_MCF10A_48H:J06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.50073 KIF21A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17308 H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ChIP_H3K36me3_18692474_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6997-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of Pal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07159 normal GeneRIF Biological Term Annotations 1.0 null Polycystic kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.741 Cortical amygdalar area, posterior part, lateral zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41818 GTEX-X261-0011-R11A-SM-4E3JY GTEx Tissue Sample Gene Expression Profiles 1.0 1.13334 protein localization GO Biological Process Annotations 2025 1.0 null GTEX-T5JC-0001-SM-3NMAK GTEx Tissue Sample Gene Expression Profiles 1.0 1.0884 POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Ciliopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.301 procaine-1838 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.327205 H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.645041 GTEX-RWSA-2426-SM-47JXR GTEx Tissue Sample Gene Expression Profiles 1.0 1.72397 centrosomes GeneRIF Biological Term Annotations 1.0 null SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13809 9+0 non-motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.816 MCF7_RG108_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0151098 parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.36439 K562_Zileuton_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0156979 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.05086 K562_S3I-201_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0146091 MCF7_CUDC-907_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0129666 CDK1 Hub Proteins Protein-Protein Interactions 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null testicular cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.754537 GTEX-XMK1-0001-SM-4B64F GTEx Tissue Sample Gene Expression Profiles 1.0 1.00335 HM13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09436 Acquired metabolic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.007 PMC6985208__F2 PFOCR Pathway Figure Associations 2024 1.0 null PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-8_names_TP53 Rummagene Transcription Factor Associations 2026 1.0 null USF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Q7-1226-SM-4AD5I GTEx Tissue Sample Gene Expression Profiles 1.0 2.38167 KYO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.83722 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.572298 single organism reproductive process GO Biological Process Annotations 2015 1.0 null K562_BMS-536924_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0160195 Microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.149 FE-64-KC49_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.340899 Brain Lower Grade Glioma_LGG_TCGA-DU-8158-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Crus II, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.00674 Ciliary basal body COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.855476 H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null intermediate stratum of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32882 Seminal vesicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.219 TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC ChEA Transcription Factor Targets 1.0 null GTEX-XQ8I-0626-SM-4BOPT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.82724 Acute Myeloid Leukemia_LAML_TCGA-AB-2816-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Primary somatosensory area, mouth, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02724 homolog GeneRIF Biological Term Annotations 1.0 null COX6A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85818 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R4-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EFO-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.87223 BL8516 (CKAP2L) NURSA Protein Complexes 1.0 null CRCGN015_MCF10A.TP53.M_24H:F01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.00196 MDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44617 POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ3S-2726-SM-4BOP2 GTEx Tissue Sample Gene Expression Profiles 1.0 2.28408 SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 0175029-0000-7392 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-VJYA-1426-SM-4KL1Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.54395 TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POU2F2 ENCODE Transcription Factor Targets 1.0 null GSE224096_1_v_0_cocaine_human RummaGEO Drug Perturbation Signatures -1.0 null external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.50582 19204204-SupplementaryTable9 GeneSigDB Published Gene Signatures 1.0 null posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.69002 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Microtubule cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.359 GTEX-NPJ7-0011-R5a-SM-33HBK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.84236 GSE160017,GSE160022_1_v_0_trem2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Sarcoplasmic reticulum lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.508 midbrain reticular formation, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.930791 PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null Nephronophthisis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.644 GSE48812_8_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A24D-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUW1-0226-SM-4BOOS GTEx Tissue Sample Gene Expression Profiles 1.0 0.914557 CTCF_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-7107-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null non-membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null MYC-19915707-AK7-human ChEA Transcription Factor Binding Site Profiles 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27083 H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 496100343_TCx_possible Alzheimer's disease_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.65104 KPNYN CCLE Cell Line Gene Expression Profiles -1.0 -1.46499 H3K4me3_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE81193_0_v_4_irf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-519b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null K562_Resminostat_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0174561 medial nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04247 Brain Lower Grade Glioma_LGG_TCGA-DU-7010-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217873_1_v_0_nusap1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XLM4-2926-SM-4AT59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26891 hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04451 developmental process involved in reproduction GO Biological Process Annotations 2015 1.0 null hsa-miR-520a-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 single-multicellular organism process GO Biological Process Annotations 2015 1.0 null ginkgolide A-4121 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-SUCS-0002-SM-3NMAJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.9177 internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null amoxicillin-1265 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE193541_1_v_2_nifurtimox_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RUSQ-1926-SM-2TF6K GTEx Tissue Sample Gene Expression Profiles 1.0 0.933328 CTCF_G1E-ER4_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55C-1426-SM-48FED GTEx Tissue Sample Gene Expression Profiles 1.0 1.7201 H3K4me1_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Cytoplasmic dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.407 496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.42771 GSE171837_0_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null pepstatin-4206 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-UPJH-0001-SM-3NMDE GTEx Tissue Sample Gene Expression Profiles 1.0 0.938034 anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.868741 cyproterone-4470 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null sin3a_22783022_mcf7_lof_human_gpl570_gds4388 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 1.25227 GSE112763,GSE112767_2_v_3_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null JUND_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Olfactory tubercle Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61963 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autosomal dominant nonsyndromic deafness 25 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 Nutrition disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.041 Autosomal dominant nonsyndromic deafness 41 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.197 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.901845 Cleavage furrow COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.614 flutamide-3803 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null mitosis Phosphosite Textmining Biological Term Annotations 1.0 null primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.889972 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null required GeneRIF Biological Term Annotations 1.0 null FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.32683 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE79572_0_v_1_pax8_human RummaGEO Gene Perturbation Signatures 1.0 null MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null THRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 62.0527 GSE48812_9_v_1_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null AA-23-FM46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.248651 bed nucleus of the external capsule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06391 superficial stratum of isBI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16768 efo21 HPA Cell Line Gene Expression Profiles -1.0 -1.06017 COLO 794 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03675 lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.37837 ACC3 BioGPS Cell Line Gene Expression Profiles -1.0 -1.11444 Orofaciodigital syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.052 PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A48F-01A-11R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE144453,GSE144454_1_v_0_tfdp1_human RummaGEO Gene Perturbation Signatures -1.0 null phenformin-3725 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ZNF85 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.8082 GSE116930,GSE116935_1_v_0_hes7_human RummaGEO Gene Perturbation Signatures 1.0 null tuberculosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.166319 MCF7_Azacitidine_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0171804 plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.331194 endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.383637 dense fibrillar component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.49661 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null SPI1 ENCODE Transcription Factor Targets 1.0 null cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.65043 reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.049811 male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.901573 ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amoxapine-6650 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PPARG JASPAR Predicted Transcription Factor Targets 1.0 null periventricular stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53492 methazolamide-6268 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null PMC10794847-mmc5.xlsx-PIAS1_KD_down-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S4Z8-1826-SM-3K2BH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.970963 GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Stomach Smooth Muscle Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.33194 GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02294 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09447 GSE242290_3_v_11_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null GSE178340_7_v_3_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null carbohydrate metabolism disease GWASdb SNP-Disease Associations 1.0 0.269253 AURKA Activation by TPX2 Reactome Pathways 2024 1.0 null CA-73-BW50_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.49827 E2F6_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pelvic varices DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.914 Lobules IV-V, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62064 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.02971 GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20985 inner CP in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46096 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7419 intracellular part LOCATE Curated Protein Localization Annotations 1.0 null POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE233679_5_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE142210_2_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63108 GSE180982_1_v_0_mlst8_human RummaGEO Gene Perturbation Signatures 1.0 null MYCN-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null harmalol-5495 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.981611 substantia nigra reticulata, isthmic part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16533 K562_Fluorouracil_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0179527 CDK1 Pathway Commons Protein-Protein Interactions 1.0 null GSE152699,GSE152723_0_v_1_vemurafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-O5YT-0008-SM-4E3IQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.23209 H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE180789_1_v_0_hnrnpc_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WRHU-0826-SM-3MJFN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1898 hsa-miR-3064-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Lobule III, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44178 GB-46-CK08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.504363 white matter of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37389 CRCGN008_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.1474 Centrosome maturation Reactome Pathways 2014 1.0 null GSE239844_8_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null sirolimus-6940 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-T5JC-0626-SM-3NMA6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.08697 heat Phosphosite Textmining Biological Term Annotations 1.0 null CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RERFLCAD2 CCLE Cell Line Gene Expression Profiles -1.0 -1.64348 MRK-NU-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K27me3_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Male infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.292 EBF1 ENCODE Transcription Factor Targets 1.0 null MCF7_FLLL32_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0149918 VIIAt Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.53863 eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null pirlindole-5497 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null ChIP_TCFCP2L1_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null testis_7b HPA Tissue Sample Gene Expression Profiles 1.0 1.36735 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67Y-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gamma-tubulin small complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.212 H3K18ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null hsa-miR-1224-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 HDAC6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Ramelteon_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0232231 SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Retinal pigment epithelium cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.307 hsa-miR-135a TargetScan Predicted Conserved microRNA Targets 1.0 0.598666 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F4_E2F4 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.998804 shoot TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.391176 ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X261-3226-SM-3NMC3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32996 FF-06-MO73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.412544 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.973505 CRCGN010_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.89292 KYSE-150 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.890118 CEBPZ_01_75 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.62874 Indianmuntjac TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.88 Brain Lower Grade Glioma_LGG_TCGA-HT-8011-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDK1 KEA Substrates of Kinases 1.0 null PAX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.5116 POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_JNJ-26854165_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0194375 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X4XX-0011-R11A-SM-46MWQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.10211 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-7966-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11639743-mmc2.xlsx-LIN28B-gene_name_LIN28B Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-7023-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 6576_POP5_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.547283 GTEX-S7PM-0626-SM-4AD4Q GTEx Tissue Sample Gene Expression Profiles 1.0 3.6295 POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.568922 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55221 EFM-19 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.9647 HDAC2 ENCODE Transcription Factor Targets 1.0 null GTEX-TSE9-2826-SM-4DXTF GTEx Tissue Sample Gene Expression Profiles 1.0 0.884756 OVCA 432 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.973505 EKVX GDSC Cell Line Gene Expression Profiles -1.0 -1.83516 APP Pathway Commons Protein-Protein Interactions 1.0 null monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.044218 KG-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.77003 NCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.69121 CRCGN012_HEPG2_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.30341 PMC10117376-hmg-2022-ce-00467_r1-sollis-supptables_ddac311.xlsx-TS1_AP-MS_results-Table_S1_TBR1-interaction_candidates_identified_in_two_AP-MS_experiments_TBR1 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN014_HEPG2_3H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.37648 K562_GSK1070916_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154322 GTEX-PWO3-1026-SM-2I5F2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.92261 superficial stratum of r4BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02785 MAP3K14 MSigDB Cancer Gene Co-expression Modules 1.0 null SNU620 CCLE Cell Line Gene CNV Profiles 1.0 1.35919 lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.097054 MAF::NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.7183 Pyramus (VIII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62064 GSE93309_1_v_0_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BC-01-JL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.478986 Tbx6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.8222 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TT-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3913-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPV-0011-R11A-SM-2TF6F GTEx Tissue Sample Gene Expression Profiles 1.0 1.12035 SP2 ENCODE Transcription Factor Targets 1.0 null GTEX-OOBJ-2126-SM-3NB1N GTEx Tissue Sample Gene Expression Profiles 1.0 1.63686 GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.895732 Pericentriolar material COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.501 PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null axoneme COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.35813 hsa-miR-3920 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 K562_Pirarubicin_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0203194 TIMP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67778 superficial stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16615 CORL311 CCLE Cell Line Gene CNV Profiles -1.0 -1.35472 GSE202603_0_v_2_bhlhe40_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CAKI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.47189 ULK1_knockout_198_GSE60778 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 3.31966 pentamidine-639 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null 23132-87 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null colchicine_homo sapiens_gpl3386_gds1753 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Seckel syndrome 7 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.534 Abiraterone acetate_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00644513 H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.668 GTEX-W5WG-1926-SM-4KKZK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01646 KASUMI2 CCLE Cell Line Gene Expression Profiles 1.0 1.77493 GSE216273,GSE216292_14_v_6_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE86507,GSE86509_3_v_10_hoxb7_mouse RummaGEO Gene Perturbation Signatures 1.0 null penbutolol-3534 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null TFAP2C JASPAR Predicted Transcription Factor Targets 1.0 null NCI-H23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.973505 NFYB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRCA1 Pathway Commons Protein-Protein Interactions 1.0 null CRCGN017_MCF10A.WT.HP_24H:A07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.19145 H3K9ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SF268 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MCF7_Azacitidine_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0167388 GTEX-WHSE-0011-R11A-SM-3P5YY GTEx Tissue Sample Gene Expression Profiles 1.0 0.869737 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null reduced fertility MPO Gene-Phenotype Associations 1.0 null GTEX-SJXC-0526-SM-2XCFG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80902 RH18 CCLE Cell Line Gene CNV Profiles -1.0 -1.66408 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 cytoplasmic part GO Cellular Component Annotations 2015 1.0 null GSE138001_2_v_4_rorb_mouse RummaGEO Gene Perturbation Signatures 1.0 null tonsil HPA Tissue Gene Expression Profiles 1.0 1.12245 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J8-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.39693 SP2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebellum_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.954981 cdkn1b_18180298_3t3_lof_mouse_gpl1261_gse9161 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 1.71275 outer dense fiber GO Cellular Component Annotations 2015 1.0 null Copula pyramidis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.53308 FC-20-EQ58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.237549 cerebellar nuclei of CbV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08539 GSE215086_8_v_0_batf_human RummaGEO Gene Perturbation Signatures 1.0 null K562_Fulvestrant_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0154204 hsa-miR-518d-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 GSE152441,GSE152442_0_v_5_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE128730_0_v_5_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-RU1J-1026-SM-46MUR GTEx Tissue Sample Gene Expression Profiles 1.0 1.00443 fosfosal-4239 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.33474 GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83101 ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.659953 microtubule organizing center part GO Cellular Component Annotations 2015 1.0 null OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.909046 r7 part of parapyramidal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09414 CEBPB_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Egg yolk TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.151 Vestibular hair cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.741 DBH_KO_GSE33906_53_mouse_heart (E10.5) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE152441,GSE152442_0_v_2_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE222598_1_v_0_sf3b4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE179031_3_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE226983_2_v_0_ddx5_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE102870_3_v_9_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE198165,GSE198166_8_v_1_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.859864 SP in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29838 molecular_function GO Molecular Function Annotations 2015 1.0 null CRCGN014_HEPG2_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.63428 hsa-miR-499a-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.474009 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.995366 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CB-06-FE89_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.228612 CREB1 ENCODE Transcription Factor Targets 1.0 null proxymetacaine-6492 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null K562_PF-573228_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0234573 nifedipine-1856 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null NRL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.9932 K562_2-Methoxyestradiol_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0270546 GSE163282_12_v_8_aspirin_human RummaGEO Drug Perturbation Signatures 1.0 null BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Seminiferous epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.875 superficial stratum of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17421 primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.25833 GTEX-WHSE-3126-SM-3P5ZI GTEx Tissue Sample Gene Expression Profiles 1.0 1.42303 GSE157262,GSE157268_3_v_0_ythdc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.948198 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.06166 USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Zona pellucida TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.829 TAF7_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.960852 yohimbic acid-4082 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ME1 CCLE Cell Line Gene CNV Profiles -1.0 -2.88599 ZNF384 ENCODE Transcription Factor Targets 1.0 null GSE57871_5_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_3_RFX1 Rummagene Transcription Factor Associations 2026 1.0 null intracellular organelle GO Cellular Component Annotations 2015 1.0 null FXR MotifMap Predicted Transcription Factor Targets 1.0 null capan2 HPA Cell Line Gene Expression Profiles -1.0 -0.863115 CRCGN015_MCF10A_48H:H13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80735 niflumic acid-5071 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-SJXC-1226-SM-4DM78 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.961911 embryonic lethality before implantation MPO Gene-Phenotype Associations 1.0 null PMC10679653-mmc2.xlsx-ISL1_KO_Markers_E-Unnamed_0_ISL1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4747-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GTEX-XOTO-0011-R11B-SM-4B64O GTEx Tissue Sample Gene Expression Profiles 1.0 0.929812 GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.91606 GSE241622_1_v_0_ythdc2_human RummaGEO Gene Perturbation Signatures 1.0 null NR2F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 92.0702 GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11439 SC-797 (GADD45A) NURSA Protein Complexes 1.0 null hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.21858 magnocellular diagonal band nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02724 POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1 ENCODE Transcription Factor Targets 1.0 null JUN ENCODE Transcription Factor Targets 1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.915053 GSE147366_3_v_2_med13_human RummaGEO Gene Perturbation Signatures 1.0 null MEIS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.6065 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 5447_NADSYN1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.805759 posteroventral (inferior) parietal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.43964 GSE209601_2_v_3_mef2a_human RummaGEO Gene Perturbation Signatures 1.0 null MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.894905 ACTR10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.18468 A549_Curcumin_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0207157 GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35899 Thrombocytopenia_Megakaryocyte_GSE2527 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.93484 etynodiol-6678 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE126345_7_v_10_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE139455_7_v_6_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11989 9+2 non-motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.122 NCI-SNU-16 GDSC Cell Line Gene Expression Profiles -1.0 -2.35327 Ciliary membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.88 Lung squamous cell carcinoma_LUSC_TCGA-37-A5EL-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE188458_2_v_3_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VH-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal sperm flagellum morphology MGI Mouse Phenotype Associations 2023 1.0 null GSE180200,GSE180201_12_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Altretamine_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145306 trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.49095 thiamphenicol-7274 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 1.57783 Leydig cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.095 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -2.6298 STAT5A ENCODE Transcription Factor Targets 1.0 null lung TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052938 GSE166920_6_v_1_adalimumab_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PX3G-0008-SM-48U2L GTEx Tissue Sample Gene Expression Profiles 1.0 1.10725 NUGC3 CCLE Cell Line Gene CNV Profiles 1.0 1.4602 MYBL2 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8II-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-R55E-0011-R11A-SM-2TC6I GTEx Tissue Sample Gene Expression Profiles 1.0 1.21779 superficial stratum of Str Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73288 POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null orciprenaline-4831 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.95921 m2 part of substantia nigra compacta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17183 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE195582_3_v_1_pim1_mouse RummaGEO Gene Perturbation Signatures -1.0 null primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00428 estropipate-4472 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-TKQ1-0006-SM-33HBI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01586 hsa-miR-1271 TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 Lung adenocarcinoma_LUAD_TCGA-NJ-A55A-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE112860_0_v_7_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Filgotinib_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0249416 Ciliary pocket COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.31 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null K562_Quisinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0125247 diethylstilbestrol-4547 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ESR1 JASPAR Predicted Transcription Factor Targets 1.0 null Infertility, Male CTD Gene-Disease Associations 1.0 1.22112 Cerebellar cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70679 GSE227891_2_v_0_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.146 GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892481 male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.976749 H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null SMC3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE198165,GSE198166_6_v_2_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null LCMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41725 GSE210101,GSE210114_4_v_3_urod_human RummaGEO Gene Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-8165-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Female accessory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.768 NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHSE-2926-SM-3NMBG GTEx Tissue Sample Gene Expression Profiles 1.0 0.948499 tetrahydroalstonine-5728 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null superficial stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14168 immune system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.055057 PNU-0230031-3735 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null putamen Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2336 STAT3 ENCODE Transcription Factor Targets 1.0 null called GeneRIF Biological Term Annotations 1.0 null PATU8988T DepMap CRISPR Gene Dependency 1.0 4.84675 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 1.50916 FOSL2::JUNB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.919 NCI-H1155 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE226249_2_v_6_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null isthmic roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09741 alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053581 NCI-H1299 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.70686 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.972473 GSE88819_7_v_10_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE88819_1_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-TSE9-3126-SM-4DXSY GTEx Tissue Sample Gene Expression Profiles 1.0 1.44375 Nemaline myopathy 5A DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.138 H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T5JW-1826-SM-3GAE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98699 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.4595 Gustatory areas, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02228 SIN3A ENCODE Transcription Factor Targets 1.0 null critical GeneRIF Biological Term Annotations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MB-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OHPL-2026-SM-3TW8R GTEx Tissue Sample Gene Expression Profiles 1.0 0.892947 nucleus GO Cellular Component Annotations 2025 1.0 null K562_IOX2_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0175084 Lateral septal nucleus, rostral (rostroventral) part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.176 PMC10534007-Table_2.xlsx-S5_unique_up_MSC_B-721_elements_included_exclusively_in_BFTC905_MSC_up_MSC Rummagene Transcription Factor Associations 2026 1.0 null diethylstilbestrol_mus musculus_gpl6887_gse37969 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 15869706-TableS2 GeneSigDB Published Gene Signatures 1.0 null mantle zone of SePal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42306 buspirone-6743 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Dentate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20878 Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7832-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Overnutrition DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.027 BTN2A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03726 ZFP42-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null primary cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 1.05741 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7839-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WB-48-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.299656 heptaminol-1825 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null pindolol-4496 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SIN3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ7-2926-SM-3MJGQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.45433 Adrenocortical carcinoma_ACC_TCGA-OR-A5JG-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Asthenozoospermia DisGeNET Gene-Disease Associations 1.0 null GTEX-S3XE-0826-SM-4AD4U GTEx Tissue Sample Gene Expression Profiles 1.0 1.12023 GSE111247_2_v_8_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE114013,GSE114014_0_v_4_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null vomeralnasalorgan.VMO. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.61207 b82 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.571 NFYA_01_131 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61867 GTEX-V955-0726-SM-3GAFG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95641 Zic2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.6363 BICR16 CCLE Cell Line Gene Expression Profiles 1.0 2.17909 H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A5SJ-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bardet-Biedl syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.033 Decitabine_J82 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0251096 K562_SB431542_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0178366 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE120413,GSE120447_4_v_5_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_MEL cell line_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Cimetidine_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0175424 PMC11214527-mmc5.xlsx-TCF4-gene_TCF4 Rummagene Transcription Factor Associations 2026 1.0 null T3M4 BioGPS Cell Line Gene Expression Profiles 1.0 2.14579 Flagellum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.933 GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826186 GTPase binding GO Molecular Function Annotations 2025 1.0 null DCTN6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72191 H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-A5RC-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryonic lethality prior to organogenesis MPO Gene-Phenotype Associations 1.0 null TBK1.DF MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null flunarizine-7412 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null IGR-37 COSMIC Cell Line Gene Mutation Profiles 1.0 null 496100323_FWM_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.38088 GTEX-QEL4-1526-SM-447AB GTEx Tissue Sample Gene Expression Profiles 1.0 0.943481 MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hESC_Derived_CD184+_Endoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.72058 PMC7291745-12967_2020_2407_MOESM2_ESM.xlsx-Table_S1D_CCF_pairs-locus_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE115542_5_v_1_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null 496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.11641 Abscission zone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.675 FF-28-ES17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.613355 basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.46677 USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052631 GSE102505_1_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null Liver TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3664-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null MAFA MotifMap Predicted Transcription Factor Targets 1.0 null GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Vermal regions Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51762 Flocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36943 Lung adenocarcinoma_LUAD_TCGA-50-6590-01A-12R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Quercetin_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0170284 outer CP in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.42197 TGFBR2_knockout_292_GSE46150 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.82563 hsa-miR-519c-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 mitotic cell cycle phase transition GO Biological Process Annotations 2015 1.0 null amygdaloid complex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.83237 SF767 CCLE Cell Line Gene CNV Profiles 1.0 1.34472 sulfinpyrazone-6230 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AI-1226-SM-48U14 GTEx Tissue Sample Gene Expression Profiles 1.0 2.39583 GSE130081,GSE130082_5_v_10_neil2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Zic3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 33.4592 cortex of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.84913 H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF143 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.1319 GTEX-OIZH-2126-SM-3NB1P GTEx Tissue Sample Gene Expression Profiles 1.0 1.8572 MCF7_Nintedanib_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0191042 PMC7617265-EMS137094-supplement-Supplementary_Tables.xlsx-ST18-gene_ST18 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN015_MCF10A.TP53.M_24H:H10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2419 DNM1L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05798 septopallidal core nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15231 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PM-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31919 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WH-01A-22R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_NVP-BSK805 2HCl_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0155857 GSE152441,GSE152442_7_v_4_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null diflunisal-4210 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null hsa-miR-4515 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S3XE-1326-SM-4AD4H GTEx Tissue Sample Gene Expression Profiles 1.0 0.847157 GSE153871_1_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures 1.0 null MT-ND3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3536 GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:J01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.55245 H513 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE97352_1_v_2_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_Luminespib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0137576 GTEX-O5YW-0326-SM-2I5EI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01555 IZ in orbital frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03592 Loss of Nlp from mitotic centrosomes Reactome Pathways 2024 1.0 null GTEX-XLM4-0004-SM-4AT5I GTEx Tissue Sample Gene Expression Profiles 1.0 1.25019 UMUC3 CCLE Cell Line Gene CNV Profiles -1.0 -1.3325 GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20315 pituitary GTEx Tissue Gene Expression Profiles 1.0 2.18987 LS513 DepMap CRISPR Gene Dependency 1.0 4.27866 GSE119978,GSE180930_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null thioguanosine-6643 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE115542_5_v_4_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null Blood cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7398-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE248858_1_v_7_tcpobop_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25717 GTEX-Q734-0426-SM-48TZX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.891883 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pancreas_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.08688 TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.94241 GSE91015_0_v_1_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null BE-36-XE09_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.208109 K562_SNS-314 Mesylate_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0160718 TestisIntersitial BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.75251 SP1 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-O5YU-0008-SM-4E3I7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.27765 hsa-miR-504 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 PMC10541450-41419_2023_6165_MOESM3_ESM.xlsx-Normal-P53-STIC-Unnamed_3_TP53 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-582-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 8229_SNRPD2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.544553 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.60012 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A7IN-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHLHE40_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-0426-SM-2S1PU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5342 GSE171572_3_v_4_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null r1 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01233 BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE247764_3_v_2_nell2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Zona pellucida receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.318 MCF7_ENMD-2076_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0150269 SNB-19 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.615 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null ODF1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null septopallidal transition area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42233 K562_Tozasertib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140365 layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00692 microtubule cytoskeleton COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.930774 PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-Genes_with_VDR_elements_only_control_VDR Rummagene Transcription Factor Associations 2026 1.0 null K562_PHA-680632_1µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0145609 carisoprodol-1314 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34625 hsa-miR-4269 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE126463_5_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null mantle zone of Str Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1891 CDK11B Pathway Commons Protein-Protein Interactions 1.0 null PMC8437976-41416_2021_1470_MOESM2_ESM.xls-List_of_MAF_in_SNP_Rectum-Hugo_Symbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null testicular cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.648127 GSE202434,GSE202438_9_v_5_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.846409 SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Body mass index GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.830103 PMC3573729-nl3042917_si_005.xlsx-OWY_Overlap_with_ANOVA-ORKIN_NMYC_MYCN Rummagene Transcription Factor Associations 2026 1.0 null Rectum adenocarcinoma_READ_TCGA-G5-6233-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null benperidol-4196 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-X88G-0004-SM-47JZ6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09352 g2/m transition of mitotic cell cycle GO Biological Process Annotations 2015 1.0 null AA-22-UI44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.539968 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null diethylstilbestrol-3812 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null lidoflazine-5804 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null AQR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1028 USF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHD7_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE102505_1_v_2_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null K562_Dasatinib_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0138505 CEBPB_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.846409 5762_NPAT_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.514597 CTCF_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Hesperadin_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0111234 imatinib_homo sapiens_gpl96_gds3049 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.81934 harmaline-2149 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null A549_Maraviroc_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0145579 CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null zfx_17448993_embryonic_stem_cell_lof_mouse_gpl1261_gds2718 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.456572 PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Upregulated_NR2F1 Rummagene Transcription Factor Associations 2026 1.0 null ZNF782 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30046 GSE198165,GSE198166_5_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null alvespimycin-2673 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78L-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.062723 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.99205 MEKK3 Kinase Library Serine Threonine Kinome Atlas 1.0 null H3K4me3_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-XYKS-2526-SM-4BOPX GTEx Tissue Sample Gene Expression Profiles 1.0 0.92217 SERF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44086 ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82792 Hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN016_MCF10A.WT.HP_24H:D19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.27735 skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -2.06114 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.27546 USF1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ID-90-NM43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.207764 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null repaglinide-5862 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SK-MEL-28 COSMIC Cell Line Gene Mutation Profiles 1.0 null BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null molecular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88325 dioxybenzone-5699 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Tirabrutinib (hydrochloride)_H4 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0248292 GTEX-R53T-1826-SM-3GIJX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19953 HDAC1 ENCODE Transcription Factor Targets 1.0 null GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44762 Sperm annulus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.233 DCC MSigDB Cancer Gene Co-expression Modules 1.0 null GSE199034_1_v_0_pirfenidone_mouse RummaGEO Drug Perturbation Signatures -1.0 null Paraflocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26454 HCFC1 ENCODE Transcription Factor Targets 1.0 null ZFYVE16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07811 V, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.866352 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.563 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68W-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null