association dataset threshold value standardized value UGT3A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4249 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null LBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.9557 internal granular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.24628 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54401 BRD-K73051782 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72843 plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 ZFYVE9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6671 CGTHW1 CCLE Cell Line Gene CNV Profiles 1.0 2.5907 BRD-K90675978 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24527 GSE172458_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Paramedian lobule, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13349 BRD-K40496631 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42705 LMX1A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.8695 Perturb_8018_KO_PXR_SRP257678 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K41389177 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15425 rosiglitazone_mus musculus_gpl7202_gse19896 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUM-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K68300789 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.93487 CRCGN008_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.35385 CRCGN014_HEPG2_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08667 ZNF25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.56121 BRD-K62625902 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04681 regulation of cellular process GO Biological Process Annotations 2015 1.0 null BRD-K20157822 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28832 BRD-K44576681 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59362 BRD-K75186244 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00837 LHX9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04555 pyramidal layer of S Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2754 GSE119978,GSE180930_6_v_8_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null CRCGN017_MCF10A.WT.HP_24H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.34035 BRD-K95035301 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0635 CENPH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62546 PDHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81637 BRD-K16991828 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24108 Agranular insular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05001 Neuron projection membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.066 CEND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14428 BRD-K73092207 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.87 BRD-K47794327 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22196 PRELID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08686 NCI-H727 COSMIC Cell Line Gene Mutation Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6348-11A-01R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Parasubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36204 BRD-K98018160 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25981 BRD-K72060903 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42577 ARL6IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13377 NOM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42354 pyramidal layer of taenia tecta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18719 KLM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.45081 BRD-K93210276 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12292 496100497_FWM_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.05191 CRCGN016_MCF10A.TP53.M_24H:O10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.52576 single organism reproductive process GO Biological Process Annotations 2015 1.0 null Globus pallidus, internal segment Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26416 Golgi lumen COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.606 Postsubiculum, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20598 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48637 BRD-K76748254 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36508 UACC257 DepMap CRISPR Gene Dependency 1.0 2.78264 SYK_knockdown_279_GDS3609 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.32267 CEBPD JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.3862 dorsal thalamus_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.59467 Prostate-basal cell of prostate epithelium Tabula Sapiens Gene-Cell Associations 1.0 9.22026 BRD-K68743686 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32126 JUND ENCODE Transcription Factor Targets 1.0 null BRD-K68858233 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.61094 PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF Rummagene Transcription Factor Associations 2026 1.0 null NUGC-3 GDSC Cell Line Gene Expression Profiles -1.0 -1.43906 Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A3QF-01A-31R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K40841951 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3359 BRD-K81642886 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.08243 Taenia tecta, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72888 HUT78 CCLE Cell Line Gene CNV Profiles -1.0 -1.97362 BRD-K39394160 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.34762 WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16778 KBTBD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67722 Lung squamous cell carcinoma_LUSC_TCGA-77-6845-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HOP92 BioGPS Cell Line Gene Expression Profiles -1.0 -1.06623 FOXP3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.8799 PMC12315868-Supplemental_Data_S1.xlsx-Supplemental_Data_S1F-TP53_TP53 Rummagene Transcription Factor Associations 2026 1.0 null SW900 CCLE Cell Line Gene Expression Profiles -1.0 -1.59449 EMC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.2395 inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.72378 BARHL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.7909 detection of chemical stimulus GO Biological Process Annotations 2015 1.0 null SH10TC DepMap CRISPR Gene Dependency 1.0 2.08404 Subiculum, dorsal part, stratum radiatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19657 c2c12 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.934149 ramipril-6792 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZNF217_OE_GDS4885_317_human_MDA-MB-231 breast cancer cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null intrinsic component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.105834 BRD-K03506285 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40931 Orbital area, medial part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96112 Hippocampal formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24475 BHY DepMap CRISPR Gene Dependency 1.0 2.27015 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.828446 nucleus of the inferior collicular brachium, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07643 INSR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39571 GSE153907,GSE153908_0_v_1_azathioprine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE218060_2_v_4_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null RL DepMap CRISPR Gene Dependency 1.0 3.29466 BRD-K73394628 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11633 Lobules IV-V, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03873 FBXO9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49506 hindbrain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40902 RAB3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.58543 LHX9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.9246 BRD-K60587793 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50745 IRF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30023 Gustatory areas, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85095 RCOR1 ChEA Transcription Factor Targets 1.0 null kasugamycin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10615 BRD-K20644549 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29905 BRD-K96624721 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2814 GSE221327_6_v_0_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.970715 BRD-K24443173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.33923 UOK101 CCLE Cell Line Gene Expression Profiles -1.0 -1.45624 Prostate adenocarcinoma_PRAD_TCGA-HC-8258-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K97339945 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28296 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SS-01A-12R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040178 PRSS16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20176 SK-BR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.895604 HOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6414 OTUD4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06923 BRD-K08753635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51874 primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08563 POU4F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 43.957 HESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1688 Dorsal peduncular area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25014 NCIH1666 DepMap CRISPR Gene Dependency 1.0 2.1304 mantle zone of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58906 PSIP1_Deficiency_GDS2883_633_human_T-cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null RUNX1 ChEA Transcription Factor Targets 1.0 null RUNX1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN014_HEPG2_24H:B08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7013 ARAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14169 retrosplenial cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16881 Male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.182 mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.895687 CRCGN008_HEPG2_24H:G24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.26595 MAK16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52089 HCC44 DepMap CRISPR Gene Dependency 1.0 2.26311 KDM5A ENCODE Transcription Factor Targets 1.0 null Pallidum, dorsal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16371 CRCGN010_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.62451 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1MI-01A-11R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUP-T1 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE119978,GSE180930_2_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN015_MCF10A_48H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.78029 anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.825606 TestisLeydigCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.889588 SCARA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63412 GSE148657_2_v_1_cd44_human RummaGEO Gene Perturbation Signatures 1.0 null Male reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.171 BRD-K13130949 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11872 CRCGN009_HEPG2_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.55349 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.843014 CANT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.66341 IRF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.2864 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5894-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PABIR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78785 HCC1569 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.911529 ARHGDIG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65534 BRD-K07756997 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36998 DYNC2I2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05314 CRCGN015_MCF10A_48H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.93732 Anchored component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.017 BRD-K75275329 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15654 BRD-K54467766 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43349 BRD-K44062658 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1941 BRD-K97878521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15332 HPAC CCLE Cell Line Gene Expression Profiles 1.0 1.36794 ST6GALNAC6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6251 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6948-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.29869 CRCGN013_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.72877 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22551 BRD-K59041191 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14899 ZBTB26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50547 Nucleus of the brachium of the inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53893 TBC1D16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32665 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4784-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE221327_8_v_0_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67581 GSE129153_0_v_1_forskolin_human RummaGEO Drug Perturbation Signatures -1.0 null HCC2911 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.85446 SLC3A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98643 SW620 COSMIC Cell Line Gene Mutation Profiles 1.0 null succinylcholine-chloride LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16972 BRD-K67591072 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05139 dorsal subnucleus of MG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2651 PACADD137 DepMap CRISPR Gene Dependency 1.0 2.84431 BRD-K64531971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11916 eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DQ-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SETBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.15779 CRCGN014_HEPG2_24H:I12 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.88745 Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IL17RA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.39338 CDK9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69933 TE11 DepMap CRISPR Gene Dependency 1.0 2.15838 BRD-K14019014 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26653 CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 HDMYZ DepMap CRISPR Gene Dependency 1.0 2.80222 orbital frontal cortex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.94213 Brain Lower Grade Glioma_LGG_TCGA-P5-A5F2-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HSG BioGPS Cell Line Gene Expression Profiles -1.0 -1.22134 Perturb_8870_KD_PNN_SRP063860 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.59776 Perturb_620_OE|KO_GFI1|IKZF1_SRP288676 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.70814 LUDLU1 DepMap CRISPR Gene Dependency 1.0 2.27892 superficial stratum of r3Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13769 KMT5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38019 BRD-K34602185 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53262 PMC4595011-pgen.1005555.s003.xlsx-MITF_DOWN-regulated-Gene_name_MITF Rummagene Transcription Factor Associations 2026 1.0 null POU2F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.0133 MST1R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.13356 Primary somatosensory area, upper limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.12883 layer 1 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04145 POU6F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6157 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6228-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null retroreuniens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17653 HCC2218 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.26563 CRCGN017_MCF10A.WT.HP_24H:P06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.44795 BRD-K27525139 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20679 mantle zone of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.20169 CRCGN011_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2191 chlortalidone-3198 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.913443 RPRM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28376 NOZ DepMap CRISPR Gene Dependency 1.0 3.75308 ventrolateral prefrontal cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.7693 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050668 Primary somatosensory area, upper limb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93839 basal plate of m1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06844 MOLM16 CCLE Cell Line Gene CNV Profiles 1.0 1.37967 amygdaloid complex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.861574 Acute Myeloid Leukemia_LAML_TCGA-AB-2851-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8020666-pnas.2015855118.sd09.xlsx-LPS_24_chimp_DRSG_higherRes-Ensemble_gene_id_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Rectum adenocarcinoma_READ_TCGA-DY-A1DG-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K09337184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16008 HNRNPA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45877 HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.7724 TIMM17B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88712 BRD-K15654812 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09475 BRD-K22137463 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81005 496100489_HIP_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.53676 CRCGN014_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.33535 TATDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.065 hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18792 GSE80537_3_v_2_adhfe1_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K67856917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77541 BRD-K34106082 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06528 anterior (rostral) cingulate (medial prefrontal) cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.52047 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46805 ZC3H12A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26965 BRD-K91022335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04644 ATF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.5375 BRD-K23704908 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.8032 TTC30A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27043 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-7351-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r3 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24777 BRD-K36852613 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02845 Crus 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49706 BRD-K07390518 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93432 BRD-K51167279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19607 SHOX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.5799 SOX10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.4564 OPLAH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65888 H3K27me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZNF766 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6587 BRD-K05970499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29839 CACNA2D2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36247 FU97 CCLE Cell Line Gene CNV Profiles 1.0 2.08505 BRD-K63375777 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0252 PMC4815041-NIHMS715090-supplement-Supplementary_Table_10.xlsx-CCF_DP_clustering-Hugo_Symbol_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null Field CA2, stratum pyramidale Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08423 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05192 TE6 DepMap CRISPR Gene Dependency 1.0 2.1818 KHM1B CCLE Cell Line Gene CNV Profiles 1.0 1.34136 BRD-K54877231 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71433 PSN1 DepMap CRISPR Gene Dependency 1.0 3.37814 POU3F1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.6379 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.934498 RNF122 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01127 BRD-K65883179 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07685 BRD-K71210410 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.13627 CRCGN013_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.95586 CRCGN016_MCF10A.TP53.M_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.208 HOXB5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5392 KE97 CCLE Cell Line Gene Expression Profiles 1.0 2.34344 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A24D-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.TP53.M_24H:B17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01585 BRD-K36730085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08685 MAFK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05193 PMC12172627-NIHMS2085635-supplement-5.xlsx-E2F1_GENIE_Results-Unnamed_1_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null HCC2450 DepMap CRISPR Gene Dependency 1.0 2.48971 IPC298 CCLE Cell Line Gene CNV Profiles 1.0 1.76516 Orbital area, ventrolateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52021 Lung squamous cell carcinoma_LUSC_TCGA-77-8148-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_6723_KD_PUM2_SRP066895 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.72071 CRCGN014_HEPG2_24H:H05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.09278 IGFBP5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01027 mantle zone of the IG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09305 FOXO1::FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.9324 BRD-K88802328 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46347 CRCGN015_HEPG2_48H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.40938 chr19_14787436_G_A_b38 GTEx eQTL 2025 1.0 2.27052 BRD-K62800316 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43966 Orbital area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.23475 VSIG10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67989 CRCGN017_MCF10A.TP53.M_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.30365 UT7 CCLE Cell Line Gene CNV Profiles 1.0 1.68729 BRD-K19603900 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39376 ventrolateral prefrontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.843014 oseltamivir-phosphate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47769 posteroventral (inferior) parietal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.849219 GSE221327_1_v_0_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null LHX6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.0427 ZBTB48 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83607 BRD-K30038014 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26279 NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.859332 BRD-K59709341 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34475 BRD-K91648652 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17281 Orbital area, ventrolateral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09534 COBL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7293 subbrachial nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05328 dorsolateral prefrontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.41602 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.924934 primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.09759 cell part GO Cellular Component Annotations 2015 1.0 null RAB22A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07979 ATG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05753 BRD-K35544244 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77166 Geniculate group, dorsal thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10834 POU4F2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.0653 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7828-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU1040 CCLE Cell Line Gene Expression Profiles 1.0 1.49346 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7103-01A-21R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Testis BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.935495 FOXP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3266 CRCGN015_MCF10A_48H:F01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4374 ERF::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.5369 Head and Neck squamous cell carcinoma_HNSC_TCGA-RS-A6TO-01A-32R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of SeDg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2221 Prostate adenocarcinoma_PRAD_TCGA-KK-A7B2-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CLK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98641 BRD-K53936012 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.96071 EZH2 ENCODE Transcription Factor Targets 1.0 null Agranular insular area, dorsal part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.71897 CRCGN017_MCF10A.WT.HP_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.9341 SIX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91708 Gustatory areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38666 superficial stratum of r4Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36476 496100277_FWM_no dementia_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.36107 organism form TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050901 NR1I3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.7993 beta-catenin-TCF7L2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.665 ICMT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12997 SKMEL5 BioGPS Cell Line Gene Expression Profiles 1.0 0.955181 Rectum adenocarcinoma_READ_TCGA-AF-2687-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1187 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.63691 primary motor-sensory cortex (samples)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05104 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73Q-01A-21R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PCM6 CCLE Cell Line Gene Expression Profiles 1.0 1.92568 BRD-K24512597 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93855 MBOAT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15992 Olfactory organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.968 layer 6 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17353 BRD-K24640918 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16192 BRD-K60044070 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16548 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040382 SU8686 CCLE Cell Line Gene Expression Profiles -1.0 -2.52054 BRD-K60837711 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.746 cell part LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K40816903 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13543 496100452_HIP_possible Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.11355 NCIH2405 CCLE Cell Line Gene CNV Profiles -1.0 -1.50856 FOXO6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.0569 male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4769-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.25263 KIF5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78909 BRD-K74988798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57564 gamete generation GO Biological Process Annotations 2015 1.0 null EMX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.832 Leading edge membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.204 primary auditory cortex (core)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.24503 midecamycin-6745 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NR3C1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.3644 GSE171311_0_v_1_ellagic acid_human RummaGEO Drug Perturbation Signatures 1.0 null r2 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17785 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03561 ZCWPW1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36283 GJA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32838 GFI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8724 VSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.9883 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.829396 184B5 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.733744 BRD-K60653414 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5382 ventrolateral prefrontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.34901 HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16885 LP1 DepMap CRISPR Gene Dependency 1.0 4.05875 SMIM14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15981 Seminal vesicle fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.019 Adrenocortical carcinoma_ACC_TCGA-OR-A5KU-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DANG DepMap CRISPR Gene Dependency 1.0 2.3 CRCGN010_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0689 VIPAS39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30656 LMX1B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1518 phthalylsulfathiazole-3033 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CACUL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4523 Rectum adenocarcinoma_READ_TCGA-EI-6513-01A-21R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HS688AT CCLE Cell Line Gene Expression Profiles -1.0 -1.65966 BRD-K13817284 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04596 lateral part of alar m1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61103 U2OS DepMap CRISPR Gene Dependency 1.0 3.45451 rostral interstitial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19274 Coagulating gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.862 CRCGN015_HEPG2_48H:G01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.4116 striatum_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.59936 SARS-BatSRBD_Day2_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.71457 Serotonergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.572 BRD-K56272400 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33939 parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43301 HSF1_KD_GDS1733_756_human_HeLa cells - 2 Hour by siHSF1_2 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null URGCP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5021 HCC2157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2636 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN017_MCF10A.WT.HP_24H:N10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0381 BRD-K34095226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06608 molecular layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.47701 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7413-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MIXL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31527 Lung squamous cell carcinoma_LUSC_TCGA-34-5240-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100376_FWM_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.8692 HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.933481 RUNX1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null NCIH520 DepMap CRISPR Gene Dependency 1.0 3.97897 HH CCLE Cell Line Gene Expression Profiles 1.0 2.01961 RTL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49487 Acute Myeloid Leukemia_LAML_TCGA-AB-2817-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ONS76 DepMap CRISPR Gene Dependency 1.0 3.74108 FOXH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04543 496100278_FWM_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.95668 ZCCHC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.47826 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NCI-H64 GDSC Cell Line Gene Expression Profiles 1.0 1.76409 NCI-H2227 COSMIC Cell Line Gene Mutation Profiles 1.0 null HEXIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78658 BRD-K55505527 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79751 reproductive process GO Biological Process Annotations 2015 1.0 null GSE135350_3_v_7_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FP-01A-21R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.37936 MERO83 DepMap CRISPR Gene Dependency 1.0 2.5283 SMYD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34159 Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.417 PMC3348545-NIHMS263168-supplement-3.pdf-381-RFX1_RFX1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K19662956 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62402 CRCGN017_MCF10A.WT.HP_24H:E10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.0617 OVK-18 COSMIC Cell Line Gene Mutation Profiles 1.0 null TRAPPC6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.08408 bed nucleus of the external capsule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17055 BRD-K34363290 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00467 cellular_component GO Cellular Component Annotations 2015 1.0 null BRD-K63171151 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.02802 membrane LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K19133474 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18824 male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null signaling receptor activity GO Molecular Function Annotations 2015 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4912-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSDMD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.02334 Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WV-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A4CL-01A-41R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.961992 KHM1B CCLE Cell Line Gene Expression Profiles 1.0 1.46931 BRD-K89514545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04698 BHT101 CCLE Cell Line Gene Expression Profiles -1.0 -1.81254 SKGT4 DepMap CRISPR Gene Dependency 1.0 2.31216 BRD-K80210288 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28653 HOXD9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.3312 PHTF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74737 CRCGN014_HEPG2_24H:F03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.54086 Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UMUC9 DepMap CRISPR Gene Dependency 1.0 2.43608 BRD-K61726189 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22803 BRD-K04741797 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08532 CRCGN016_MCF10A.TP53.M_24H:H09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.61542 CRCGN010_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.01265 HCC1428 CCLE Cell Line Gene CNV Profiles -1.0 -1.5277 MYL6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53356 cinoxacin-5783 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SNU466 CCLE Cell Line Gene Expression Profiles 1.0 1.49303 BRD-K18255961 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22868 Orbital area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44357 HOXD4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.3698 C11orf54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53885 BRD-K96778009 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.85285 FLI1::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.1886 BRD-K31678817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01751 CRCGN014_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.161 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.977352 MDAMB231 DepMap CRISPR Gene Dependency 1.0 4.40375 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03456 CRCGN017_MCF10A.WT.HP_24H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.78845 mantle zone of r1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21583 Dorsal peduncular area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.55983 Skin-melanocyte Tabula Sapiens Gene-Cell Associations 1.0 -0.121658 rhombomere 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.61391 SMAD3-18955504-HaCaT-human ChEA Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7793-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN011_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66985 CRCGN010_HEPG2_24H:I17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.15205 Olfactory Signaling Pathway Reactome Pathways 2014 1.0 null PBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8333 Colorectal Carcinoma DisGeNET Gene-Disease Associations 1.0 null Simple lobule, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55355 PPDPF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.03801 MYC_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2978-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PLBD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6722 DUX4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5201 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.511 CDC42EP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28326 CRCGN008_HEPG2_24H:L04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.9564 H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mediodorsal nucleus of thalamus_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.834357 NCI-H716 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.562 ATAD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69133 CAPRIN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.06757 BRD-K62892366 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20598 BRD-K91628074 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.61062 TLE5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99414 ETV5::FOXO1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.3859 CRCGN015_HEPG2_48H:J10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.35927 GRAMD1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.73452 BRD-K92613860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04002 Primary somatosensory area, nose, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99182 primary auditory cortex (core)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.45415 intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null NOMO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35034 posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.89955 plasma membrane GO Cellular Component Annotations 2015 1.0 null HLCS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92098 anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.19037 dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14473 BRD-K02106348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53807 NCIH226 CCLE Cell Line Gene Expression Profiles -1.0 -1.69517 NOTO JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.3199 Supraspliceosomal complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.127 mantle zone of r1BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31807 SW480 CCLE Cell Line Gene Expression Profiles 1.0 1.96557 CRCGN013_HEPG2_24H:G16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.19775 KATOIII CCLE Cell Line Gene CNV Profiles -1.0 -1.8554 TMEM47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14844 BRD-K59626557 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55767 CRCGN009_HEPG2_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.77454 EPLC-272H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.934498 Epitheloid cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.722 BRD-K41999717 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42402 HCC1937 CCLE Cell Line Gene CNV Profiles 1.0 1.40148 BRD-K89524688 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32922 BRD-K49039223 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23974 PML CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47101 ST486 CCLE Cell Line Gene Expression Profiles 1.0 1.59382 Prostate adenocarcinoma_PRAD_TCGA-EJ-7793-01A-31R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null C1QL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21239 BRD-K75618633 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78313 Neuroendocrine carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.538 CRCGN008_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.22485 BRD-K21246672 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.19579 CRCGN015_MCF10A_48H:M07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.01941 TRIM59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73951 BRD-K49664555 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16871 orbital frontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.921836 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Chloride channel complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.876 FBLIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21975 DUSP7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.79176 anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.81482 PMC4595011-pgen.1005555.s001.xlsx-BPTF_UP-regulated-Ensembl_gene_id_BPTF Rummagene Transcription Factor Associations 2026 1.0 null Primary somatosensory area, nose, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.94707 DRGX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42145 halcinonide-3680 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null adult TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.253578 CRCGN015_MCF10A.WT.HP_24H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.75922 PRDM5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51693 BRD-K78961368 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45125 CRCGN015_MCF10A_48H:H03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.31272 TUNAR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52221 MYLA DepMap CRISPR Gene Dependency 1.0 2.76785 FSBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.95183 female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null g-protein coupled receptor signaling pathway GO Biological Process Annotations 2015 1.0 null BRD-K63996931 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09578 NFYA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3573 nucleus of the stria terminalis, medial division, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14551 PAX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3662 BRD-K32071534 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15536 HOXA5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4622 Taenia tecta, dorsal part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62194 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.27503 KDSR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94234 TBC1D22B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93785 BRD-K46015322 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10796 BRD-K43170571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65687 Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35605 OCIM1 CCLE Cell Line Gene CNV Profiles 1.0 2.20836 TCF7L2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9308 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A8P0-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of the IG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09455 NR3C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94227 Ansiform lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53893 orbital frontal cortex_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.933851 SR-95639A-3272 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN014_HEPG2_24H:H15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0627 HEL9217 CCLE Cell Line Gene CNV Profiles 1.0 1.82644 HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null FOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.6741 PMC4595011-pgen.1005555.s003.xlsx-MITF_DOWN-regulated-Ensembl_gene_id_MITF Rummagene Transcription Factor Associations 2026 1.0 null Anterior olfactory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3586 Breast carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.0 BRD-K44797534 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34817 ZNF652 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3657 GSE242555_1_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.231 SCL-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE218060_7_v_4_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN008_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.67535 BRD-K04192660 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47834 Primary somatosensory area, upper limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.09985 BRD-K92803674 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0931 FOXA3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.539 inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.917131 IMPDH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45435 Crus 2, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29669 pyramidal layer of IG Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09455 BRD-K56276074 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38921 FOXD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 73.9035 Hemispheric regions Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.36113 Rectum adenocarcinoma_READ_TCGA-F5-6465-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN011_HEPG2_24H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.81375 BRD-K40621788 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40329 PMC10042887-41419_2023_5742_MOESM3_ESM.xlsx-Table_S3-Table_S3_Differently_expressed_genes_in_HOXB3_vs_HOXB3-_aPCA_HOXB3 Rummagene Transcription Factor Associations 2026 1.0 null TSHZ2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75582 Lung squamous cell carcinoma_LUSC_TCGA-77-A5GA-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K72488042 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0611 CRCGN015_MCF10A_48H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.8114 Rectum adenocarcinoma_READ_TCGA-F5-6810-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NAGLU CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24471 NCI-H847 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.922682 Frontal pole, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00315 SHSYSY+RA BioGPS Cell Line Gene Expression Profiles -1.0 -2.37891 BRD-K47886441 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02123 gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K86942117 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26878 G141 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.989682 BRD-K50479239 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19771 Primary somatosensory area, upper limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.95362 spanning component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.291787 CRCGN011_HEPG2_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.198 GSE182680,GSE182683_10_v_2_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null T2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.541 GSE135350_2_v_7_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null olfactory receptor activity GO Molecular Function Annotations 2015 1.0 null H3K9me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08142 LB647-SCLC COSMIC Cell Line Gene Mutation Profiles 1.0 null BDH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.46586 H4K20me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SNU-668 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.77435 OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.32119 Taenia tecta, ventral part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1301 KMS27 DepMap CRISPR Gene Dependency 1.0 2.572 GSE186471_1_v_2_carnosol_human RummaGEO Drug Perturbation Signatures 1.0 null BRD-K83752863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00581 BRD-K67734449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02241 Oral cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.841 nucleus of the stria terminalis, medial division, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76089 CRCGN015_MCF10A.TP53.M_24H:E17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.584 ACHN GDSC Cell Line Gene Expression Profiles 1.0 1.54717 molecular transducer activity GO Molecular Function Annotations 2015 1.0 null BRD-K69423881 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00769 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.239 BRD-K20520611 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04587 cortex of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.74497 Hypertrophy of breast DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.186 PHOX2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.552 UROtsa cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.734 MMD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96343 H3K27me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SW1573 CCLE Cell Line Gene CNV Profiles -1.0 -1.79069 Prostate adenocarcinoma_PRAD_TCGA-HC-7737-11A-02R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158320,GSE183351_2_v_1_lin28b_human RummaGEO Gene Perturbation Signatures 1.0 null 496100442_PCx_possible Alzheimer's disease_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.43016 NCI-H1944 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.842716 KHSRP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.90412 BRD-K65913831 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09558 PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD Rummagene Transcription Factor Associations 2026 1.0 null HOXA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0141 YT COSMIC Cell Line Gene Mutation Profiles 1.0 null LGR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36066 GSE214583,GSE214585_1_v_0_steap1_human RummaGEO Gene Perturbation Signatures 1.0 null Lobules IV-V, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09228 ZNF416 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.8725 Brain Lower Grade Glioma_LGG_TCGA-CS-5396-01A-02R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K48260102 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04316 BRD-K77875023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29279 intrinsic component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.12939 Lung squamous cell carcinoma_LUSC_TCGA-56-A4BY-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K61795707 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.93123 PRRX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.1474 CRCGN017_MCF10A.WT.HP_24H:N16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.58765 Locus ceruleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10834 BRD-K10459972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12202 CRCGN016_MCF10A.TP53.M_24H:O20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.47889 Infralimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.98925 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MDAMB415 CCLE Cell Line Gene CNV Profiles -1.0 -1.37383 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K53552465 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30769 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_1day-MOI-10^4_None_GSE44445 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.87567 YIPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6571 BMS-270394 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16991 CSDE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95695 CELF4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85325 Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MEOX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.0035 Olfactory receptor neuron TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.511 BRD-K01762107 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.05571 496100543_FWM_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.55907 Lung adenocarcinoma_LUAD_TCGA-44-A479-01A-31R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PGLS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.55631 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03456 MEX3C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67507 SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.824604 NCI-H358 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46805 BRD-K57786028 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33039 CRCGN015_MCF10A.TP53.M_24H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.0538 H357 DepMap CRISPR Gene Dependency 1.0 4.39833 CRCGN012_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48199 EFO27 CCLE Cell Line Gene Expression Profiles -1.0 -1.5429 Bone marrow TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BRD-K67665252 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56225 PA-TU-8988T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950805 BRD-K07870648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25724 BRD-K74261250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20471 BRD-K73088636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02019 YY1 ENCODE Transcription Factor Targets 1.0 null RMUGS CCLE Cell Line Gene CNV Profiles -1.0 -1.73444 FAM20B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84517 HOXB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.1193 MON2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.74867 MAPK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74249 Prostate adenocarcinoma_PRAD_TCGA-HC-7211-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DPH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98231 CRCGN017_MCF10A.WT.HP_24H:K22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8179 Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.165 intermediate stratum of APal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27781 intermediate stratum of r2BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62597 CRCGN015_HEPG2_48H:F19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.10451 CRCGN010_HEPG2_24H:C19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.26961 G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.998856 OV90 CCLE Cell Line Gene CNV Profiles -1.0 -1.61005 GAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31537 mantle zone of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16932 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NOVA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.99918 H3K27me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K81110981 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50699 anterior olfactory area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5903 COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32146 CD8+_Tcells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.08648 BRD-K61310138 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35137 CRCGN017_MCF10A.WT.HP_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.26655 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SQ-01A-21R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posteroventral (inferior) parietal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.67381 BRD-K86722849 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02025 BRD-K32787834 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4001 layer 2 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36039 upper dorsal lateral hypothalamic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04582 ZFAND1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37382 central amygdaloid nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27849 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06394 BRD-K81956993 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18351 PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1 Rummagene Transcription Factor Associations 2026 1.0 null Posterolateral visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05328 BRD-K08650286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09571 Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.33891 CTV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null TMX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70805 BRD-K56837922 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13298 Retrosplenial area, ventral part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23219 BRD-K53717076 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68512 posteroventral (inferior) parietal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28978 NABP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51428 EKVX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.829396 YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null WSB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42476 GPCR downstream signaling Reactome Pathways 2014 1.0 null Sensory ganglion TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.226 Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5ST-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NEMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98339 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20B-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Respiratory mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.578 BRD-K09487932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52746 GATA3-27048872-CHIP-SEQ-THYMUS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GS-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LRP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44991 SELENOF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24268 CRCGN017_MCF10A.WT.HP_24H:P05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.17213 ABL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20406 CRCGN012_HEPG2_24H:K01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.91308 BRD-K47001624 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15666 HOXA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4037 DMRTC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6618 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7424-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K23429973 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68578 BRD-K54507743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.86771 RBM26 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54489 Dorsal peduncular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61749 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KC-11A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBLC1 DepMap CRISPR Gene Dependency 1.0 2.18604 BRD-K61691014 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11807 spinalcordlower BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.834672 HASPIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68982 BRD-K72255288 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03796 detection of stimulus GO Biological Process Annotations 2015 1.0 null BRD-K41025232 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12332 NFYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4342 IGROV1 BioGPS Cell Line Gene Expression Profiles 1.0 1.43194 CRCGN015_HEPG2_48H:G06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.21231 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HS-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K26273412 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03445 CRCGN013_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.15394 Lung squamous cell carcinoma_LUSC_TCGA-77-7142-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null IBTK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38927 CRCGN015_MCF10A_48H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.9715 Anterolateral visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07141 FUS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.56861 PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-19q13_43_TP63 Rummagene Transcription Factor Associations 2026 1.0 null External side of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.61 GSE125219,GSE125221_5_v_2_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K63061929 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19148 Lung squamous cell carcinoma_LUSC_TCGA-85-8048-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80094 KMS-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.86817 JEKO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.62388 multicellular organismal reproductive process GO Biological Process Annotations 2015 1.0 null GSE135350_2_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null TIGD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15069 BRD-K90693562 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00227 CRCGN012_HEPG2_24H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.95985 lomofungin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21254 SEMA4C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23244 Breast - Mammary Tissue GTEx Tissue Gene Expression Profiles 2023 1.0 3.21525 Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6X0-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H1-2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72244 BRD-K36099605 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57629 RCC-FG2 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 2.13718 Expression and translocation of olfactory receptors Reactome Pathways 2024 1.0 null CRCGN015_MCF10A_48H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.3922 CRCGN011_HEPG2_24H:A09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21735 CRCGN011_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.55895 DAUDI CCLE Cell Line Gene Expression Profiles 1.0 1.74956 ENTPD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72628 Flocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04592 TMEM107 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78639 ZC3H14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35068 SNU245 CCLE Cell Line Gene CNV Profiles -1.0 -1.50428 ISCA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.36493 Acute Myeloid Leukemia_LAML_TCGA-AB-2849-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFKBIA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.28047 FOXC1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.2386 thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.22013 LTBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38235 HCC38 DepMap CRISPR Gene Dependency 1.0 2.03147 ITGB3BP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09375 Infralimbic area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.39756 EBPL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14117 NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32146 NOS1 DepMap CRISPR Gene Dependency 1.0 2.00231 HSF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.1358 layer 5 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18696 H3K27me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K31147434 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37871 Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30643 Taenia tecta, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.20257 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.92243 HRAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0096 CRCGN009_HEPG2_24H:F20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.8452 RKO COSMIC Cell Line Gene Mutation Profiles 1.0 null Paramedian lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37443 Olfactory Signaling Pathway Reactome Pathways 2024 1.0 null HCC1143 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 Lung squamous cell carcinoma_LUSC_TCGA-21-1082-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null RBM18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60138 DUSP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57228 BRD-K88278778 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67397 Lung squamous cell carcinoma_LUSC_TCGA-56-7221-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SKG-IIIa GDSC Cell Line Gene Expression Profiles -1.0 -1.45485 BC-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null UMUC1 DepMap CRISPR Gene Dependency 1.0 2.08382 MRPL54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69496 primary motor cortex (area M1, area 4)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40721 CRCGN008_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5944 Supratrigeminal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05328 BRD-K69355244 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03437 BRD-K62979806 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.154 Primary somatosensory area, nose Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.73523 BRD-K24396733 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23608 PACADD165 DepMap CRISPR Gene Dependency 1.0 2.89141 PRICKLE3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.31379 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10105 HEL CCLE Cell Line Gene CNV Profiles 1.0 1.59316 plasma membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04317 BRD-K63987422 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20658 PF382 CCLE Cell Line Gene Expression Profiles -1.0 -1.95416 BRD-K91859707 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15872 bed nucleus of the stria terminalis, medioseptal division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22147 membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043275 CRCGN015_HEPG2_48H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.93436 PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR Rummagene Transcription Factor Associations 2026 1.0 null LDHA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70549 MCIDAS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.48644 BRD-K66526269 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41124 Rectum adenocarcinoma_READ_TCGA-F5-6702-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AB-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.14898 BRD-K75007044 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15404 POU4F3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.3627 r4 part of medial paralemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21919 BRD-K01334037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.63976 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A4BK-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r9 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00744 RNF149 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.5899 PSPH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88854 ventrolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.835287 NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.970715 MAP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.05567 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7261-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC515 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.829396 CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44681 STRN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.89266 Sensory Perception Reactome Pathways 2024 1.0 null GSE140937,GSE140938_0_v_2_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05002 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.934498 Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.11125 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN011_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.4566 GSE195663_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06499 ZBTB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.40802 Prostate adenocarcinoma_PRAD_TCGA-HC-7747-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.58166 Olfactory transduction KEGG Pathways 2026 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LO-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of DgSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27608 mantle zone of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61103 CRCGN011_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.24725 r5 part of the oral Sp5 subnucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24105 GSE147366_1_v_4_med13_human RummaGEO Gene Perturbation Signatures -1.0 null primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.87445 SKHEP1 DepMap CRISPR Gene Dependency 1.0 2.89126 IRF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.3797 BRD-K29549246 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79694 mediodorsal nucleus of thalamus_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.956089 BRD-K39074860 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.03212 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Subparafascicular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01102 GSE218060_7_v_0_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.62388 BRD-K50432649 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08362 ZNF667 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9755 ZFP41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7474 RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.62388 BRD-A56909893 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47905 regulation of biological process GO Biological Process Annotations 2015 1.0 null BRD-K18447546 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2098 RHOB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.06149 Lung squamous cell carcinoma_LUSC_TCGA-46-3768-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_CH12.LX_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K95500387 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73579 g-protein coupled receptor activity GO Molecular Function Annotations 2015 1.0 null BRD-K52119965 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.03412 SW837 CCLE Cell Line Gene CNV Profiles -1.0 -2.0588 BRD-K22405104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62657 BRD-K98545272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17117 LUDLU1 CCLE Cell Line Gene CNV Profiles -1.0 -1.3253 BRD-K67535324 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09846 IKZF2_01_137 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.71776 CCDC9B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95649 MAN1B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.82251 membrane part GO Cellular Component Annotations 2015 1.0 null HSF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5735 NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.91244 sodium phenylbutyrate-407 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE198794_0_v_3_usp18_human RummaGEO Gene Perturbation Signatures -1.0 null lateral part of r1B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32832 CRCGN014_HEPG2_3H:N04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.4528 DPY19L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70863 OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.934498 Cerebellum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.82041 Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PPP1R37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60803 ZBTB34 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29259 BRD-K20549184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35334 integral component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.237401 H3K9me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VK-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_407_OE_DPP4_SRP353826 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 BRD-K60807536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15761 Brain Lower Grade Glioma_LGG_TCGA-S9-A7R7-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null signal transduction GO Biological Process Annotations 2015 1.0 null GSE217552_3_v_2_fisetin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_11_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null single-organism process GO Biological Process Annotations 2015 1.0 null BRD-K30674442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49654 BRD-K35133923 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48611 GSE226233_0_v_1_pccb_human RummaGEO Gene Perturbation Signatures 1.0 null pituitary GTEx Tissue Gene Expression Profiles 1.0 1.54662 Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30725 BRME1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57963 OVCAR8 BioGPS Cell Line Gene Expression Profiles -1.0 -1.13845 SKMEL2 DepMap CRISPR Gene Dependency 1.0 2.72189 BRD-K33752391 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.78293 layer 1 of PaS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43301 CRCGN014_HEPG2_24H:D13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.24194 Uterine serous carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.814 GSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6715 HINT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78723 Intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.509 HCA1 DepMap CRISPR Gene Dependency 1.0 3.43632 ZNF285 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49043 496100455_FWM_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.04971 BRD-K65945126 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52625 CRCGN017_MCF10A.WT.HP_24H:O19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.8587 BRD-K25280080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40081 BRD-K04468899 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12608 HOXA7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.0079 GOT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18984 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FM-8000-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hippocampus (hippocampal formation)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.43354 Lung adenocarcinoma_LUAD_TCGA-55-8507-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HMG20B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91977 ZNF880 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.38289 SYTL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16502 CRCGN015_MCF10A_48H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.93005 METTL9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.162 superficial stratum of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04592 CRCGN016_MCF10A.WT.HP_24H:N15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.4313 hippocampus (hippocampal formation)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.3192 FOXO4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4722 TM9SF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.25711 anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.982627 SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03561 BRD-K06181307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08477 ZNF30 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49132 chr19_14832963_A_G_b38 GTEx eQTL 2025 1.0 3.06927 CRCGN017_MCF10A.WT.HP_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9213 TIMP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45018 CRCGN008_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.36855 ATOH8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.43052 U343 CCLE Cell Line Gene Expression Profiles 1.0 1.76512 Lung squamous cell carcinoma_LUSC_TCGA-21-1075-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K24471810 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42248 H3K27me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06499 APLP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04737 CENPE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1632 SCC-9 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17894 Brain Lower Grade Glioma_LGG_TCGA-HT-7694-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.900258 BRD-K65737790 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64006 PANX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.52951 HUPT3 CCLE Cell Line Gene CNV Profiles 1.0 1.62986 BRD-K18316646 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.62939 CMTM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75634 olfactory receptor activity GO Molecular Function Annotations 2025 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A194-01A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Taenia tecta, dorsal part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44472 Supplemental somatosensory area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.30714 GGTLC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63979 UMUC3 DepMap CRISPR Gene Dependency 1.0 3.80636 KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.830212 SK-UT-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K96154586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46294 SNRPG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.3201 superficial stratum of S Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24475 CRCGN010_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6838 BRD-K17060750 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.67545 GSE182680,GSE182683_7_v_13_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7740-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mesothelioma_MESO_TCGA-SH-A7BH-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K62492257 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56766 bonemarrow BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.912177 BRD-K58025976 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35515 MOLT16 CCLE Cell Line Gene Expression Profiles 1.0 1.52803 Uterine Carcinosarcoma_UCS_TCGA-QN-A5NN-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K95294904 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11204 C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.858299 FASTKD5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.60978 BRD-K36473494 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.38996 SNU478 CCLE Cell Line Gene Expression Profiles 1.0 1.89233 ROGDI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28944 VAX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1671 DUX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.2539 OVCAR-8 GDSC Cell Line Gene Expression Profiles -1.0 -1.58275 GSE131649_2_v_11_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null TBX21 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5461 BRD-K13968264 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08964 Primary somatosensory area, upper limb, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36204 FOXC2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.0092 Perturb_533_OE_EWSFLI1_SRP033559 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.47576 prosomere 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00258 ULK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75557 GSE236504,GSE236505_0_v_1_atmin_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K03911650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48828 SOX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.5679 Brain Lower Grade Glioma_LGG_TCGA-DU-6396-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r3 part of spinal trigeminal sensory column, oral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1374 BRD-K73689413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05113 YAPC GDSC Cell Line Gene Expression Profiles -1.0 -1.8195 RSV-A2_24Hour-KO_RSV_None_GSE18170 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.05403 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TI-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FDXACB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14479 CTSB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67338 Orbital area, lateral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62274 Perturb_8094_KD_PUM2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.56396 posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.988192 ESYT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65375 Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 U-2-OS GDSC Cell Line Gene Expression Profiles -1.0 -1.71837 BRD-K08927194 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.47241 CRCGN013_HEPG2_24H:K14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.18478 OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.07317 NKX2-5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4713 CHML CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.37986 Brain Lower Grade Glioma_LGG_TCGA-S9-A6U0-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hippocampus (hippocampal formation)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.881289 GSE205729,GSE205731_2_v_3_tazemetostat_human RummaGEO Drug Perturbation Signatures 1.0 null SPATA20 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.96548 layer 1 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03173 RRS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.26082 BRD-K13320013 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27763 TTC21B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30677 Barrington's nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07643 CYBA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.64775 THRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.4286 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null septohypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64048 BRD-K59491482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52657 CRCGN016_MCF10A.TP53.M_24H:P21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.043 r4 part of descending trigeminal sensory nucleus, oral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36439 LY2 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.526104 Lung adenocarcinoma_LUAD_TCGA-95-7947-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.04989 ZNF547 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1762 G protein-coupled receptor, rhodopsin-like InterPro Predicted Protein Domain Annotations 1.0 null superficial stratum of TTe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18658 BRD-K86240647 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06161 Lung adenocarcinoma_LUAD_TCGA-53-7624-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARRDC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7842 integral component of membrane GO Cellular Component Annotations 2015 1.0 null integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GSE214931_2_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8005-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARGFX JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.22 CRCGN015_HEPG2_48H:C20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.85089 epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.45567 rhombomere 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28636 medial pallium (hippocampal allocortex) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10013 FOXK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8239 risedronate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.34967 TEAD4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2876 anterior (rostral) cingulate (medial prefrontal) cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.67299 UBA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75001 NKX2-3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80208 H3K27me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27me3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K08899466 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.82646 superficial stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17473 BRD-K73126584 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03552 H3K27me3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K47865468 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15766 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.889195 SDC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.79693 TP53_DEPLETION_GDS4070_451_human_MDA-MB-231 breast cancer cells (depleted of MUTANT-p53) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null TMEM145 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.764 striatum_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.975395 CRCGN016_MCF10A.TP53.M_24H:P20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.20941 superficial stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13349 Prostate adenocarcinoma_PRAD_TCGA-G9-6353-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ANXA7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.7626 GJD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94398 BRD-K52136059 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1555 r1 basal plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55355 intermediate stratum of m1AL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37443 BRD-K52797126 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25144 ALVA31 BioGPS Cell Line Gene Expression Profiles 1.0 1.67882 Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5576-01A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SDF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42023 Anterior olfactory nucleus, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.85987 Liver hepatocellular carcinoma_LIHC_TCGA-QA-A7B7-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-8260-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cribriform plate TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.754 MV411 CCLE Cell Line Gene Expression Profiles -1.0 -1.73796 PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-MYC_UP_V1_UP-Gene_name_MYC Rummagene Transcription Factor Associations 2026 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H0-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r9 part of nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10323 NKX6-2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.7724 SHSYSY-RA BioGPS Cell Line Gene Expression Profiles -1.0 -1.35037 H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null JHOS4 CCLE Cell Line Gene CNV Profiles -1.0 -1.36983 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 IM95 CCLE Cell Line Gene Expression Profiles 1.0 2.6549 FOXO1::ELK3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.2165 NIHOVCAR3 CCLE Cell Line Gene CNV Profiles -1.0 -1.56452 U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03456 NCKAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98288 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CASKI DepMap CRISPR Gene Dependency 1.0 2.7735 Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.148 SKMEL31 CCLE Cell Line Gene Expression Profiles 1.0 2.06557 male gamete generation GO Biological Process Annotations 2015 1.0 null ATOH7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.545 ETV7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.6395 receptor activity GO Molecular Function Annotations 2015 1.0 null PMC4595011-pgen.1005555.s001.xlsx-BPTF_UP-regulated-Gene_name_BPTF Rummagene Transcription Factor Associations 2026 1.0 null TMEM184B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17871 MDAMB361 CCLE Cell Line Gene Expression Profiles -1.0 -1.90901 primary motor cortex (area M1, area 4)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.49799 OCI-AML5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53397 CRCGN015_MCF10A_48H:G05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.8743 CRCGN015_MCF10A_48H:J16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.9404 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6L9-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63U-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ARPC1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42862 BRD-K40474424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55805 TAL1::TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.6818 F36P CCLE Cell Line Gene CNV Profiles -1.0 -2.7998 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68T-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K78169765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16048 MPI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32755 Culmen Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13349 rhombomere 11 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53893 CRCGN015_HEPG2_48H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.86816 reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K76617730 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05124 layer 2 of VPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03873 dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.13196 H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC33 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39258 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A57M-01A-51R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HGC27 CCLE Cell Line Gene CNV Profiles 1.0 1.46586 Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4552 Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Linear nucleus of the medulla Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10843 trachea BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.860786 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06499 CASTOR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01382 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.237 SMIM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.78483 2-iodomelatonin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52148 Skmes TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.856 BRD-K88494268 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29972 Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.368 intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Colonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.499 SNU81 CCLE Cell Line Gene Expression Profiles -1.0 -1.49721 Rlc TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.561 Adrenocortical carcinoma_ACC_TCGA-OR-A5JA-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NKX6-3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4056 647V CCLE Cell Line Gene Expression Profiles -1.0 -1.8395 496100313_HIP_possible Alzheimer's disease_TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.19688 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.829396 HS870T CCLE Cell Line Gene Expression Profiles 1.0 2.00145 IGFLR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7619 intermediate stratum of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.39737 BRD-K21139023 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15451 cerebellar cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.9305 NB4 CCLE Cell Line Gene CNV Profiles 1.0 1.35373 HS888T CCLE Cell Line Gene Expression Profiles -1.0 -1.69108 inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.61607 HEXB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.3704 BRD-K26647686 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.60425 FOXO1::ELF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.0596 BRD-K71537579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.71569 BRD-K02715134 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.172 NEUROG2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6315 FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2764 BRD-K33710385 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.83164 OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48637 HYAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.83573 superficial stratum of InsCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16963 MRPL21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32509 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100592_FWM_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.16392 CRCGN008_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.6286 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.933481 CAL-39 GDSC Cell Line Gene Expression Profiles 1.0 1.51056 TNK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44576 KLM1 CCLE Cell Line Gene CNV Profiles -1.0 -2.13879 TNS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74201 GTF3C1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45707 GPCRs class A rhodopsin like WikiPathways Pathways 2024 1.0 null NCIH28 CCLE Cell Line Gene Expression Profiles 1.0 1.41349 LDB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.27646 Taenia tecta, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22084 Crus 1, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29669 CRCGN009_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9287 Sperm plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.614 NUDHL1 CCLE Cell Line Gene Expression Profiles 1.0 1.71953 MS751 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.62259 MEOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.5459 CRCGN008_HEPG2_24H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33045 ZNF77 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.92851 H3K27me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UCMA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89114 BRD-K19103580 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62423 496100484_FWM_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 8.06161 CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATXN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.30338 ODR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00772 m1 (rostral) midbrain tegmentum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06844 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TU-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SF539 BioGPS Cell Line Gene Expression Profiles -1.0 -1.49585 Axolemma COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.083 BRD-K45631723 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1533 HN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15347 CRCGN015_MCF10A_48H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.03335 HBA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60802 CRCGN017_MCF10A.WT.HP_24H:E04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.38276 Purkinje cell layer of CbHCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.12883 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51T-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null chr19_14809579_G_A_b38 GTEx eQTL 2025 1.0 1.4243 BRD-K84233319 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41208 PRDM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17615 ZIM3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.9569 biological_process GO Biological Process Annotations 2015 1.0 null CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16885 IPC-298 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.4389 Prostate adenocarcinoma_PRAD_TCGA-G9-6351-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_24H:P01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.77027 SW962 GDSC Cell Line Gene Expression Profiles 1.0 1.98681 spleen BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.972791 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K76951235 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36058 inferolateral temporal cortex (area TEv, area 20)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.87445 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GI-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r10 part of external cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17411 SNU1196 CCLE Cell Line Gene CNV Profiles -1.0 -1.37183 BRD-K57517066 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11195 INO80E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97589 propidium iodide-2541 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.TP53.M_24H:F17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.5995 BRD-K89923892 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.68528 PAX9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.4957 ITM2C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73008 VPS37C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33419 Orbital area, ventrolateral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42551 CRCGN008_HEPG2_24H:G14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.33565 ZNF202 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47465 Simple lobule, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47104 PNMA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37753 integral component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.140749 RCOR1-19997604-NEURONS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null TAF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80961 BRD-K94888615 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27976 layer 3 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14956 Brain Lower Grade Glioma_LGG_TCGA-DH-A7UT-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null internal globus pallidus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15366 CRCGN011_HEPG2_24H:P03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5506 r1 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.29975 Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Minor vestibular gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.906 BRD-K62203376 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32597 H3K27me3_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K25257305 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02587 NB6 GDSC Cell Line Gene Expression Profiles 1.0 1.47575 CERS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57571 PMC9170821-JCMM-26-3183-s001.xlsx-Oligo_DAPI_ERG_VaDadj_vs_NC-Gene_ERG Rummagene Transcription Factor Associations 2026 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K40532221 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.29609 NCI-N417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.907326 Acute Myeloid Leukemia_LAML_TCGA-AB-2943-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K26826253 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13285 Perturb_17786_KO_LDBI_SRP071739 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.75149 dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.893026 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.842132 HCC202 DepMap CRISPR Gene Dependency 1.0 4.66422 BRD-K77775127 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.68369 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.0276 Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5636-01A-02R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73S-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4177-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.51 CRCGN013_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.12151 decamethonium LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05931 Ethmoid bone TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.737 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_3H:A05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.06907 hippocampus (hippocampal formation)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26124 Brain Lower Grade Glioma_LGG_TCGA-P5-A72U-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7752-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Simple lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53893 Perturb_615_KO_SLFN11_SRP233180 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.03978 Agranular insular area, dorsal part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11365 SNU201 CCLE Cell Line Gene Expression Profiles -1.0 -3.41648 CRCGN015_HEPG2_48H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.22493 PGD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98568 BRD-K22127625 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74015 CRCGN009_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.24597 CRCGN010_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.15748 CRCGN016_MCF10A.TP53.M_24H:E17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.16318 CRCGN017_MCF10A.WT.HP_24H:O21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7273 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19T-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8637-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HSPB9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.53726 BRD-K10638173 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41204 CRCGN014_HEPG2_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7251 BRD-K31559225 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03712 Acute Myeloid Leukemia_LAML_TCGA-AB-2887-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K37151525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57608 Lung squamous cell carcinoma_LUSC_TCGA-18-3408-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null acetylsalicylic acid-2664 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K30318008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29127 Signal Transduction Reactome Pathways 2014 1.0 null Colon cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.512 PK1 CCLE Cell Line Gene CNV Profiles -1.0 -1.54428 SMAD2 ChEA Transcription Factor Targets 1.0 null olfactory receptor activity GO Molecular Function Annotations 2023 1.0 null BRD-K46308702 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30893 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.889195 layer 2 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33411 CCRT CEM BioGPS Cell Line Gene Expression Profiles 1.0 2.41625 detection of chemical stimulus involved in sensory perception GO Biological Process Annotations 2015 1.0 null Thymus BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.824945 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.79843 biological regulation GO Biological Process Annotations 2015 1.0 null BRD-K48171978 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.06639 BRD-K14436020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59428 TFAP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 52.5303 DAPK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.13008 KP2 CCLE Cell Line Gene CNV Profiles 1.0 1.96473 A-375 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.48637 CRCGN009_HEPG2_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.55465 BRD-K54948591 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31933 CRCGN015_HEPG2_48H:G13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.71176 KDM4C_natural variation_GSE41040_588_human_fibroblasts fron neonatal foreskin GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null OC-314 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K00086692 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32527 BRD-K73769678 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25068 BRD-K42877297 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39053 PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_chimp_DRSG_higherRes-Hg_gene_id_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null CALML4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66297 Signaling by GPCR Reactome Pathways 2014 1.0 null TAB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.44733 BRD-K22907310 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30058 BRD-K28565184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05646 dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.55078 Lung squamous cell carcinoma_LUSC_TCGA-56-A4BX-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07643 HIP1R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80264 liminal part of alar r1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21583 Fetallung BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.885248 ZNF75A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.0355 UAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62178 GSE134029_3_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null ARPIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.95741 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRD-K31060354 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44785 cell periphery COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 BRD-K00403046 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0686 GSE258991_1_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A69E-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAFAZZIN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.93967 EOLA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09615 BRD-K62555617 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40955 NCIH292 DepMap CRISPR Gene Dependency 1.0 2.97866 CTAGE9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.42332 Subceruleus nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01704 L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29815 HOXB7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5376 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06499 PMC3712200-584604.f1.pdf-6-MBNL2_MBNL2 Rummagene Transcription Factor Associations 2026 1.0 null PYCR2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.01503 Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A7CF-02A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF274 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.2323 POLR2J2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14048 Taenia tecta, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10512 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A1HS-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H835 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_Symbol_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.913689 laterodorsal tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10834 primary motor cortex (area M1, area 4)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.3184 BICRAL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.27205 BRD-K70618663 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00739 TE4 DepMap CRISPR Gene Dependency 1.0 4.01014 COLO-704 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.05215 ALKBH6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00435 MIGA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4327 Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NMD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.54015 dihydroergotamine-4502 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE140936,GSE140938_0_v_1_slfn11_human RummaGEO Gene Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IU-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MCC26 COSMIC Cell Line Gene Mutation Profiles 1.0 null CROCC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85634 BRD-K28187112 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.64896 EW-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null Orbital area, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43641 MOLM-13 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.517 EML3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.57782 NCIH1435 CCLE Cell Line Gene CNV Profiles -1.0 -1.57445 RH30 DepMap CRISPR Gene Dependency 1.0 2.38298 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BS-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K82292504 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46312 ARL8B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3537 Skeletal system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 BRD-K11662217 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20369 posteromedial visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09228 BRD-K90048234 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38693 BRD-K39185798 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11932 496100396_HIP_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.91428 LOX-1_OE_GDS4262_434_human_HAECT - aortic endothelial cell line - 12 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.171 BRD-K89770910 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18583 Bed nuclei of the stria terminalis, anterior division, ventral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31239 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YI-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN010_HEPG2_24H:G15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.34167 KANK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.07627 BRD-K11719436 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01081 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7072-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0074 CME1 DepMap CRISPR Gene Dependency 1.0 2.37414 Brain Lower Grade Glioma_LGG_TCGA-CS-6188-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOXB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.1381 BRD-K74382273 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03332 TBCD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15795 GSE157684,GSE173391_0_v_1_rgcc_human RummaGEO Gene Perturbation Signatures 1.0 null CDX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.4079 Lung squamous cell carcinoma_LUSC_TCGA-63-A5ML-01A-31R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K72098339 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07104 FOXO1::ELK1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.2332 CRCGN014_HEPG2_3H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.0308 ILKAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74303 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JP-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.TP53.M_24H:P16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.13499 NEUROD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.01735 BRD-K91513229 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20118 496100463_FWM_possible Alzheimer's disease_no TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.50622 RD CCLE Cell Line Gene Expression Profiles -1.0 -1.59144 SLC46A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58285 BRD-K98169006 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17631 LIVF001-027 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65782 Prostate adenocarcinoma_PRAD_TCGA-EJ-7328-01A-31R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.07673 EVX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.4074 BRD-K15098674 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54662 cefadroxil-4161 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K65291993 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0512 HCC1143 COSMIC Cell Line Gene CNV Profiles 1.0 4.51153 TNNC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.85115 BRD-K40164971 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30241 catenin-TCF7L2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.664 DYNC1I2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74363 TP73 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.785 superficial stratum of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58906 SCG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67403 BRD-K12097074 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.23034 EVX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.5498 0225151-0000-6389 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null DNAJC18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12683 CRCGN011_HEPG2_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8253 HOXA3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.8328 BRD-K29441085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12642 Perturb_3648_KO_MTF2_ERP115567 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.093 ELL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15238 CRCGN015_MCF10A_48H:P04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.9421 CRCGN009_HEPG2_24H:L08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.6211 Rectum adenocarcinoma_READ_TCGA-EI-6511-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A4-Fuk GDSC Cell Line Gene Expression Profiles 1.0 1.64263 Adrenocortical carcinoma_ACC_TCGA-OR-A5LM-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SCL-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null PMC12616242-can-24-3452_supplementary_table_s2_suppst2.xlsx-Up_bins-Up_bins_gaining_H3K27me3_in_hpMSC-EWSR1_FLI1_FLI1 Rummagene Transcription Factor Associations 2026 1.0 null Presubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10834 TT2609C02 CCLE Cell Line Gene Expression Profiles -1.0 -2.68866 Cerebellar cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93839 PMC10335677-pbio.3002161.s009.xls-MLL_siRNA_DEGs-Ensembl_ID_KMT2A Rummagene Transcription Factor Associations 2026 1.0 null PLCPRF5 DepMap CRISPR Gene Dependency 1.0 2.91333 PRKCG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73376 Periosteal osteogenic sarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.1 ZSCAN25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17473 Agranular insular area, ventral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23414 LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.998856 TGBC11TKB COSMIC Cell Line Gene Mutation Profiles 1.0 null ETV2::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.7221 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22377 mantle zone of S Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24475 PANC0327 CCLE Cell Line Gene CNV Profiles 1.0 1.39707 ZNF827 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.75965 Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7915-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUR-01A-21R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Olfactory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.453 OE21 DepMap CRISPR Gene Dependency 1.0 2.10144 MOS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22298 SMAD2-18955504-HACAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null ACAD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.69093 BRD-K04968881 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2134 UBR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09696 BRD-K03287885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25588 CRCGN010_HEPG2_24H:K02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.17954 TRIM41 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89181 BRD-K56801250 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34562 PLCB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.45086 BRD-K25408656 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80718 Anchored component of membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.713 BRD-K99847716 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.2957 cell surface receptor signaling pathway GO Biological Process Annotations 2015 1.0 null GSE140997_4_v_1_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null PRRG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.82013 BRD-K18692529 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11487 HOXB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6565 Agranular insular area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21431 OVSAHO CCLE Cell Line Gene CNV Profiles 1.0 1.75844 Orbital area, medial part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21719 BRD-K59957369 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38909 nucleus of the inferior collicular brachium, caudal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33914 Colon Carcinoma DisGeNET Gene-Disease Associations 1.0 null BRD-K96057608 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22777 GSE133329_0_v_3_trim28_human RummaGEO Gene Perturbation Signatures 1.0 null BRD-K22874335 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05867 GSE135514_2_v_5_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.13541 Adrenocortical carcinoma_ACC_TCGA-OR-A5JL-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9860384-mmc2.xlsx-Table_S4-Table_S4_2016_VCF_Shared_Variants_related_to_the_results_TBX1 Rummagene Transcription Factor Associations 2026 1.0 null PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null cyproheptadine-6740 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K60701773 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01853 CRCGN013_HEPG2_24H:O06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.66239 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HE-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JMJD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20828 BRD-K03352270 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24701 Gracile nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31169 LIVF001-022 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60719 HOXB4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6446 Acute Myeloid Leukemia_LAML_TCGA-AB-2890-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Subiculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47104 BRD-K91397206 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.4353 TDGF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.65078 Lobules IV-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12494 BRD-K65250438 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48691 pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.9944 abamectin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86697 membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GSE186647,GSE217288_2_v_4_hnrnpc_human RummaGEO Gene Perturbation Signatures -1.0 null GSE104604_1_v_0_eif5a_human RummaGEO Gene Perturbation Signatures 1.0 null Paramedian lobule, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43301 BRD-K12067186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21216 BRD-K65789952 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19281 BRD-K41498330 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18124 Crus 1, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71554 BRD-K83139520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06366 BRD-K35196805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0493 Acute Myeloid Leukemia_LAML_TCGA-AB-2842-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K36353158 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25557 CRCGN012_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.29722 Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CHRNA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.705 BRD-K31602570 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04146 CRCGN015_MCF10A.WT.HP_24H:M16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.7358 RTN4R CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.55911 Primary somatosensory area, mouth, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38603 REXO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.63354 BRD-K27911943 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.00366 BRD-K79370456 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24372 superficial stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00238 SLC30A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.04316 STX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44238 ATP5PF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46193 FAM234A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8363 FZR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22105 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22377 cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.20169 MYF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.7731 rhein LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.2496 BRD-K81644801 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02475 posterior (caudal) superior temporal cortex (area 22c)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.61607 anterior pretectal nucleus, ventral superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13349 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.06617 ZBTB17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34667 KMRC20 CCLE Cell Line Gene CNV Profiles -1.0 -1.63964 SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.950805 JEKO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.62041 HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32146 UACC893 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.542065 epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051013 BRD-K87399364 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48395 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ZNF317 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.2634 BRD-K35073835 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40699 BRD-K76147162 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29663 POLG CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.68588 COL2A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34989 EEF1B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.47438 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XE-01A-12R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11033585-BLOOD_BLD-2023-021752-mmc2.xlsx-S10_DGEA_IKZF1-Supplemental_Table_10_Differentially_expressed_genes_between_IKZF1_and_all_other_subcluster_IKZF1 Rummagene Transcription Factor Associations 2026 1.0 null BON-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.937 r8 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0006 BRD-K26376097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.53577 BRCA1_DEPLETION_GDS2189_121_human_MCF10A mammary epithelial cells (MECs) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PDCD11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36035 CRCGN014_HEPG2_24H:K13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.54715 HSF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.2623 detection of chemical stimulus involved in sensory perception of smell GO Biological Process Annotations 2015 1.0 null membrane GO Cellular Component Annotations 2015 1.0 null BRD-K38244121 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6041 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.251 ZNF582 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 30.9693 BRD-K72128077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08458 PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_2-1769_genes_are_more_than_four-fold_upregulated_in_PRDM8-_-_compared_to_control_PRDM8 Rummagene Transcription Factor Associations 2026 1.0 null adrenal gland GTEx Tissue Gene Expression Profiles 1.0 0.938097 SNU1196 DepMap CRISPR Gene Dependency 1.0 2.74646 BRD-K72135113 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40331 Taenia tecta Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54317 Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 orbital frontal cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16323 PMC11732233-mmc1.pdf-273-PBX2_PBX2 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K77483143 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32112 SKBR3 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.01686 Supplemental somatosensory area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.93037 CRCGN011_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.2813 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MEA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.81546 intermediate stratum of r8Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00111 insular cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16994 FGF21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.23691 Pons, motor related Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03873 SNU-423 GDSC Cell Line Gene Expression Profiles -1.0 -1.49135 Septohippocampal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.69077 Retrohippocampal region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62597 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68W-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K53387776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31041 layer 6b of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58295 NCO2 DepMap CRISPR Gene Dependency 1.0 3.02028 COMMD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.57829 HEK 293 T-rex BioGPS Cell Line Gene Expression Profiles 1.0 1.11942 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DPYSL5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.33538 ZNF189 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.0359 striatum_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28578 HDQP1 CCLE Cell Line Gene CNV Profiles 1.0 2.33407 VAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.5731 GM97 BioGPS Cell Line Gene Expression Profiles 1.0 1.21811 LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36885 BRD-K18313650 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18313 Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.153 Orbital area, ventrolateral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25046 HOXA4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.1277 TTLL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.05207 OCI-M2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22705 CENPVL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.73532 BRD-K28803288 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45807 CTXN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51411 Orbital area, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43714 FADU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.949826 striatum_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.79569 BRD-K56222361 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17808 GSE242555_1_v_0_fn3k_human RummaGEO Gene Perturbation Signatures 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUN-01A-12R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nasal mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.617 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MN-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K31330911 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.07118 LIVF001-016 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.74214 BRD-K74789550 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67562 signal transducer activity GO Molecular Function Annotations 2015 1.0 null Ejaculatory duct TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.604 Paraflocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15082 PMC9404532-NIHMS1788564-supplement-Supplementary_Tables_1-8.xlsx-Supp_Table_6-MYC_UP_V1_UP_MYC Rummagene Transcription Factor Associations 2026 1.0 null BRD-K48710089 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8512 HMGXB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.70038 BRD-K00909602 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.62541 FGF19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09394 layer 3 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.84884 MECP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.602 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K66214118 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.0327 Orbital area, medial part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.01699 Spondylometaphyseal dysplasia Sedaghatian type DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.053 induseum griseum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09685 NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12059 KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.22377 CL-34 COSMIC Cell Line Gene Mutation Profiles 1.0 null GPCR, rhodopsin-like, 7TM InterPro Predicted Protein Domain Annotations 1.0 null Prostate cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.177 primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.96944 Rectum adenocarcinoma_READ_TCGA-G5-6641-01A-11R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.67581 molecular_function GO Molecular Function Annotations 2015 1.0 null ncih727 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.665 KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r3BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24676 CRCGN015_MCF10A.TP53.M_24H:P21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.41315 PRSS50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.89655 Acute Myeloid Leukemia_LAML_TCGA-AB-2899-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IQCB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62971 MSC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 42.0347 r2 part of basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61103 CRCGN016_MCF10A.WT.HP_24H:D07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5062 BRD-K61414850 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14243 EP300_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11223 LARP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.24247 octreotide LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23193 IDH3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.12572 primary auditory cortex (core)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06931 Gustatory areas, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.958 Nose TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.737 GSE146546,GSE146807_0_v_1_igf2bp1_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K07914894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04368 CORL279 CCLE Cell Line Gene CNV Profiles 1.0 1.51391 SMAD3 ChEA Transcription Factor Targets 1.0 null MAX ENCODE Transcription Factor Targets 1.0 null PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-MYC_UP_V1_UP-Ensemble_gene_ID_MYC Rummagene Transcription Factor Associations 2026 1.0 null BRD-K33230547 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41183 NR3C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.2693 GSE140997_4_v_7_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null BRD-K61845512 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19194 Orbital area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37263 FU97 CCLE Cell Line Gene Expression Profiles 1.0 1.5129 BRD-K03953354 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24239 LDAH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07479 ZNF777 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.3612 BRD-K43159427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42393 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4760-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K88351048 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43789 DND-41 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-A13210451 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47152 NCO2 CCLE Cell Line Gene CNV Profiles 1.0 1.49779 BRD-K64317740 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08667 BRD-K93460493 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15022 DEPDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.59472 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.31751 BRD-K28276275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55376 GSE182680,GSE182683_10_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null NUP58 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07763 BRD-K60132279 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21179 primary motor cortex (area M1, area 4)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 3.21362 KATO III Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.7851 Olfactory receptor InterPro Predicted Protein Domain Annotations 1.0 null ZNF496 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.77624 BRD-K77890526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.03025 COX6B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92905 LHX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.6529 bone marrow HPA Tissue Protein Expression Profiles 1.0 1.8377 NAT8L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17838 T3M10 CCLE Cell Line Gene CNV Profiles 1.0 1.43207 BRD-K76544773 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40254 POLR2A ENCODE Transcription Factor Targets 1.0 null GALR3_GALP LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05575 JOSD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17368 BRD-K74842791 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29636 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08142 Entorhinal area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22549 BT483 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.46223 CRCGN015_MCF10A_48H:G06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04756 ARMC10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98147 CRCGN012_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.69665 FOXD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3 GSE135350_3_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null prepontine hindbrain Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.20169 BRD-K24308170 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.84662 CRCGN015_HEPG2_48H:E13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.53511 Lung squamous cell carcinoma_LUSC_TCGA-63-A5M9-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMAD2-18955504-HaCaT-human ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K35671498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29616 BRD-K61807670 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36795 posteromedial visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18696 Lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.053 BRD-K14442101 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.46566 posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.884255 CCDC25 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74537 posteroventral (inferior) parietal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.951495 Kidney renal clear cell carcinoma_KIRC_TCGA-DV-A4VZ-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K73230533 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.45752 Flocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32832 chr19_14831879_G_A_b38 GTEx eQTL 2025 1.0 1.34916 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JG-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null nih 3T3 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.28267 PATU8902 DepMap CRISPR Gene Dependency 1.0 2.58371 HOXB3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.2348 TEF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7978 CSNK2A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86025 Retrosplenial area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12786 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LD-01A-12R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN011_HEPG2_24H:O02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.93545 CRCGN008_HEPG2_24H:O03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.33245 CRCGN014_HEPG2_24H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.51286 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5100-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NKX6-1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.9176 CRCGN016_MCF10A.WT.HP_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.4945 HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.991468 Perturb_970_OE_SRSF1_SRP174924 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.00865 CRCGN013_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4209 SMAD3-18955504-HACAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SLC12A9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.6073 BRD-K43261169 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15745 VSX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.6506 GBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.0463 Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCVADR RES BioGPS Cell Line Gene Expression Profiles -1.0 -1.45826 SW780 CCLE Cell Line Gene CNV Profiles -1.0 -1.59737 Acute Myeloid Leukemia_LAML_TCGA-AB-3002-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior cortical amygdaloid area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10834 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.934498 Prostate adenocarcinoma_PRAD_TCGA-HC-7738-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25687 TUHR10TKB DepMap CRISPR Gene Dependency 1.0 2.30679 EN2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.0588 GSE172016_2_v_1_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null orbital frontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31278 PK59 CCLE Cell Line Gene CNV Profiles 1.0 1.82798 a24 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.335 posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.97339 496100490_HIP_no dementia_no TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.85628 Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-IS-A3K7-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 3 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51096 Agranular insular area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56385 SW 1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54401 CRCGN015_MCF10A.WT.HP_24H:P22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.08521 pregnenolone-4218 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PGAM4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7623 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 orlistat-6388 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.8252 RMND5B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.71812 TGS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34184 prostate GTEx Tissue Gene Expression Profiles 1.0 1.06197 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null RPL29 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.15908 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.09017 A-Vietnam-1203_CIP048_RG4-2004(H5N1)NS1trunc124_1day-MOI-10^3_None_GSE44445 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.07961 IQSEC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.97522 lateral part of r2B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.64068 plasma membrane LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K39206254 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73251 SNU668 CCLE Cell Line Gene CNV Profiles 1.0 1.69217 CRCGN017_MCF10A.WT.HP_24H:A21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4807 Prostate disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.175 HCC1419 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.29969 PMC4595011-pgen.1005555.s003.xlsx-BPTF_UP-regulated-Gene_name_BPTF Rummagene Transcription Factor Associations 2026 1.0 null MID1IP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.771 Eye-melanocyte Tabula Sapiens Gene-Cell Associations 1.0 0.177124 BRD-K33260002 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.88918 inferolateral temporal cortex (area TEv, area 20)_21 pcw_M_12886 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.96994 PPP1R2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.663 MV-4-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.903208 CRCGN009_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.65365 Dorsal peduncular area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.16684 spanning component of plasma membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.291787 EPB41L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.70584 spermatogenesis GO Biological Process Annotations 2015 1.0 null internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CALHM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11888 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A7WF-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K39449072 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08325 IM-95 COSMIC Cell Line Gene Mutation Profiles 1.0 null Anterolateral visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24072 SuperiorCervicalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.05207 BRD-K18558473 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.88136 HOXB2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.7383 AN3CA CCLE Cell Line Gene Expression Profiles 1.0 3.40796 H3K9me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ITGA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62082 GSE171180,GSE171181_0_v_1_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null aklomide LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20571 GPCRs, Class A Rhodopsin-like(Homo sapiens) WikiPathways Pathways 2014 1.0 null GSE140997_4_v_3_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null MELHO CCLE Cell Line Gene Expression Profiles 1.0 1.57138 ZNF234 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.20234 OE33 DepMap CRISPR Gene Dependency 1.0 2.07391 ARID1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92579 Sarcoma_SARC_TCGA-DX-A7EI-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRF8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.6001 primary auditory cortex (core)_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.23708 BRD-K76115264 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31026 MEG01 CCLE Cell Line Gene Expression Profiles 1.0 1.59458 BRD-K33272704 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03944 ZSWIM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.41537 BRD-K16780806 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54161 RPS6KA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.02518 SW579 CCLE Cell Line Gene CNV Profiles 1.0 1.79208 TC71 DepMap CRISPR Gene Dependency 1.0 5.71354 GSE189336_1_v_0_nitric oxide_human RummaGEO Drug Perturbation Signatures -1.0 null EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16885 BRD-K06091213 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16092 CRCGN015_MCF10A_48H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.18577 HMGA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.98031 Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CRCGN017_MCF10A.WT.HP_24H:O15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0491 transmembrane signaling receptor activity GO Molecular Function Annotations 2015 1.0 null TEAD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.2472 mantle zone of r2BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65456 Globus pallidus, external segment Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16461 BRD-K86298765 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26673 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4XL-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pralidoxim LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33388 EFO27 DepMap CRISPR Gene Dependency 1.0 2.6109 BRD-K33438042 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46 COPS7B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.49322 BT483 CCLE Cell Line Gene CNV Profiles -1.0 -1.58538 detection of stimulus involved in sensory perception GO Biological Process Annotations 2015 1.0 null Respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 HENMT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39744 megestrol-6667 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BARX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.108 Small intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.273 PMC8020666-pnas.2015855118.sd09.xlsx-LPS_24_chimp_DRSG_higherRes-Hg_gene_id_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16778 PDX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.4841 BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.16731 phloridzin LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4178 Olfactory epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.685 BRD-K65257143 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.12674 EP300 ENCODE Transcription Factor Targets 1.0 null Infralimbic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51096 BRD-K05335635 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.48449 SNU1076 CCLE Cell Line Gene CNV Profiles -1.0 -2.30214 HOXC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.1456 Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ATXN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.94863 BRD-K84077642 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11459 BRD-A70931301 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36168 KYSE-450 GDSC Cell Line Gene Expression Profiles -1.0 -2.45023 PAQR7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.32347 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.19301 Sarcoma_SARC_TCGA-X6-A8C3-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null M/G1 phase-specific MADS box-forkhead transcription factor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.589 FBXL16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.93405 CRCGN009_HEPG2_24H:M19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.61005 SLC29A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92973 Medial geniculate complex, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2549 BRD-K87530935 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14183 CRCGN014_HEPG2_24H:A17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.82506 ANKIB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.07576 GSX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 13.3373 QKI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83771 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r4 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.66591 blood GTEx Tissue Gene Expression Profiles -1.0 -0.946887 BRD-K22957824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.55042 BRD-K41604824 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.28996 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4688-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null tilorone LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.68446 Brain Lower Grade Glioma_LGG_TCGA-E1-5302-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K42455540 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59021 ZNF211 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7872 DUXA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.1326 UNC93B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.11127 CRCGN016_MCF10A.TP53.M_24H:N14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 6.7527 SEPTIN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22873 BRD-K65873444 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18968 BRD-K42247636 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.81177 GSE147669_2_v_1_tram2_human RummaGEO Gene Perturbation Signatures 1.0 null Malignant Tumor Of Colon DisGeNET Gene-Disease Associations 1.0 null MYF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.4026 BRD-K20735575 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05462 superficial stratum of r4BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61709 FOXK2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4536 HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21043 Gustatory areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2551 GSE216043_11_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Claustrum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2608 mediodorsal nucleus of thalamus_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29876 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.04989 KU1919 CCLE Cell Line Gene Expression Profiles -1.0 -2.21613 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null A-431 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.54401 HCFC1R1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.14245 HOXC8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.1536 HOXA13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.886 THAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.71039 CRCGN016_MCF10A.TP53.M_24H:P18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.29239 PATU8988S CCLE Cell Line Gene Expression Profiles 1.0 1.45385 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BHLHE23 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6995 mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31592 BRD-K76309489 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32714 KLF13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.10532 BRD-K84439371 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19201 PCNX2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.5468 PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null layer 1 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12494 dioxybenzone-5699 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.13178 GSE240896,GSE240899_3_v_0_ccnt1_human RummaGEO Gene Perturbation Signatures -1.0 null PBX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.5973 IKZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4074 CRCGN015_MCF10A_48H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.7185 SJRH30 GDSC Cell Line Gene Expression Profiles 1.0 1.78445 GSE119978,GSE180930_0_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null CRCGN012_HEPG2_24H:O01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.64649 BRD-K68401280 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59746 superficial stratum of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24138 CRCGN014_HEPG2_24H:J18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.5619 BRD-K25064302 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.01775 ZNF558 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 86.0489 H4K20me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCIH1836 CCLE Cell Line Gene CNV Profiles 1.0 1.52034 ST3GAL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72185 ETV5::FOXI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.3203 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.15347 BRD-K05111274 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09628 response to stimulus GO Biological Process Annotations 2015 1.0 null ESX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.4749 CRCGN015_MCF10A.WT.HP_24H:K18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.60949 CRCGN015_HEPG2_48H:J17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.50191 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.142 KG1C CCLE Cell Line Gene Expression Profiles -1.0 -1.79634 SCLY ChEA Transcription Factor Targets 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null Perturb_6624_KD_DDX5_SRP237546 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.25062 GSE131649_4_v_11_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null superficial stratum of cerebellar hemisphere Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.74497 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KD-11A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF131 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.10552 mast cells BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.08116 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HR-01A-21R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor-sensory cortex (samples)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14475 SLC17A7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62008 NCIH1944 CCLE Cell Line Gene CNV Profiles -1.0 -2.42899 TestisSeminiferousTubule BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.23596 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 TMEM201 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.67941 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null TLCD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83439 TTLL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.03314 Anterior olfactory nucleus, posteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38603 PANC 03.27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.998856 CRCGN013_HEPG2_24H:I16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.21358 OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.889195 Lung squamous cell carcinoma_LUSC_TCGA-33-6738-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE173232_1_v_3_sf3b1_human RummaGEO Gene Perturbation Signatures -1.0 null FMR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.2158 BRD-K75041866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07148 BRD-K88472400 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00674 N-acetyl-L-leucine-5683 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HIPK2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.31477 CRCGN011_HEPG2_24H:O04 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8877 CRCGN015_MCF10A.TP53.M_24H:J07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3821 Brain Lower Grade Glioma_LGG_TCGA-QH-A6X8-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K09960817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43112 AU565 DepMap CRISPR Gene Dependency 1.0 3.03868 CAL27 CCLE Cell Line Gene Expression Profiles -1.0 -2.10689 Infralimbic area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47995 SUM185PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.16683 BRD-K02535446 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08519 PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_chimp_DRSG_higherRes-Ensemble_gene_id_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null IL15_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null CRCGN015_HEPG2_48H:B10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.99708 TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.58574 CRX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.6155 placenta BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.903042 HUP-T3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.47882 lateral septal nucleus, intermedio-ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23546 HES7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51707 striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.970034 JMSU1 CCLE Cell Line Gene Expression Profiles -1.0 -1.87881 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.13 Tongue-schwann cell Tabula Sapiens Gene-Cell Associations 1.0 -0.0419827 Acute Myeloid Leukemia_LAML_TCGA-AB-2820-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JE-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN009_HEPG2_24H:O05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.33165 BRD-K97934318 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03829 Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.3611