association	dataset	threshold value	standardized value
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.75416
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASXL1	ChEA Transcription Factor Targets	1.0	null
cisplatin_homo sapiens_gpl570_gds3910	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC6754502-41598_2019_50051_MOESM3_ESM.xlsx-Br_to_Fay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
YY1-23942234-MYOBLASTS-AND-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC8592830__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K72336314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53195
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
docl1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.225
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE186660_2_v_1_nicotine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE141624_3_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.92045
GOT1	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular response to stress	GO Biological Process Annotations 2015	1.0	null
BRD-K14589361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3714
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
negative regulation of dna repair	GO Biological Process Annotations 2015	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03155
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09845
IKBKE	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05783
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.746821
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47412
BRD-K57833824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32751
PMC8393865__F3	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08064
Prostate adenocarcinoma_PRAD_TCGA-EJ-7325-01B-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TUBA1A	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4777381-pone.0150624.s006.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE148695,GSE167281_2_v_1_satb2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.147
TMEM107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0599
GSE97352_1_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
together	GeneRIF Biological Term Annotations	1.0	null
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RH30	CCLE Cell Line Gene CNV Profiles	1.0	2.14171
liposarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.714005
PUS1	Pathway Commons Protein-Protein Interactions	1.0	null
MDM2	Pathway Commons Protein-Protein Interactions	1.0	null
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.754
BRD-K81660107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23651
protein binding	GO Molecular Function Annotations 2015	1.0	null
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
BRD-K67832115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74154
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.38435
TAF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K14262397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.73955
ESCRT complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.461
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.691
SUM229PE	DepMap CRISPR Gene Dependency	1.0	2.17299
CRCGN015_MCF10A_48H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.356
enzymes	GeneRIF Biological Term Annotations	1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG5-0426-SM-2I5GJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78781
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319771
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.739094
G-361 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
PMC6848891-DataSheet_1.xlsx-Supplementary_Table_4-Supplementary_Table_4_STAT3_partner_proteins_as_determined_by_mass_spectrometry_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BFTC-909	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844684
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K57586808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4051
SRRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02415
G-292-Clone-A141B1	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.14921
BIN67	DepMap CRISPR Gene Dependency	1.0	3.80707
Ubiquinone biosynthesis complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.136
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
death	GeneRIF Biological Term Annotations	1.0	null
LD-69-ZV56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284964
GTEX-WWYW-3026-SM-3NB36	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20835
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.40429
GTEX-U4B1-0526-SM-4DXTK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.946493
Medial geniculate body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.172
GAMT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601523
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7611
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.920381
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124410_3_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.505409
outer CP in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00259
NB17	DepMap CRISPR Gene Dependency	1.0	3.76474
BB-93-VT73_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.636059
MCF7_AZ 960_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0120023
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.955917
NCI-H2009	GDSC Cell Line Gene Expression Profiles	-1.0	-1.94248
DKMG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67632
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329873
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.977027
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE146612_2_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE232564,GSE232566_0_v_2_nsd2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE137144_3_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6424098-mmc5.xlsx-CEBP_Binder-Gene_names_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
Sense organ	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE150669_0_v_3_roxadustat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
RAB10	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906311
ENTPD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44383
SKMM2	CCLE Cell Line Gene CNV Profiles	1.0	2.249
GATA3	JASPAR Predicted Transcription Factor Targets	1.0	null
regulation of organelle organization	GO Biological Process Annotations 2015	1.0	null
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305663
decreased grip strength	MGI Mouse Phenotype Associations 2023	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hand	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.007
RPS2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE140607_5_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41N-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MCAS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Esophageal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.451
EFO21	DepMap CRISPR Gene Dependency	1.0	2.5195
RBBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34265
urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.071337
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ubch5	GeneRIF Biological Term Annotations	1.0	null
Nectar	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.732
SW 1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.882246
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.847912
GSE231648_4_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.923161
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.318042
Gastric cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.471
BRD-K91271834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41825
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.33336
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF1	ChEA Transcription Factor Targets	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PHF8-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S27_LF_C2_24h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
NSDHL	Pathway Commons Protein-Protein Interactions	1.0	null
induction	GeneRIF Biological Term Annotations	1.0	null
GAPDH	Pathway Commons Protein-Protein Interactions	1.0	null
Penis_Foreskin_Keratinocyte_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.51453
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.686
GATA2-19941826-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
LRWD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13651
CASP14	Pathway Commons Protein-Protein Interactions	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.730575
GSE123825_2_v_3_glud1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K13076765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25268
regulation of TORC1 signaling	GO Biological Process Annotations 2025	1.0	null
NCI-H1573	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K32839286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0881
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01246
IZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19439
JARID1A-20064375-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CNDP2	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73G-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UterusCorpus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.30586
FOXA2	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3619-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K46951445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0387
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19671
assays	GeneRIF Biological Term Annotations	1.0	null
posteroventral (inferior) parietal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0028
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.89072
coralyne-1298	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KDM1A	ENCODE Transcription Factor Targets	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228413_2_v_1_mavs_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFFL	Pathway Commons Protein-Protein Interactions	1.0	null
Transport vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.171
GSE142210_3_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HEBP2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GE-34-TW62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386407
lymphnode_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.23273
Lung adenocarcinoma_LUAD_TCGA-78-7542-01A-21R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
linkages	GeneRIF Biological Term Annotations	1.0	null
IFITM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7073
ANP32B	Pathway Commons Protein-Protein Interactions	1.0	null
3537_GRINA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.769273
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.794
HEC265_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	4.62598
GSE149075_6_v_0_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AE-71-CB15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.425959
inferolateral temporal cortex (area TEv, area 20)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.975472
Lung squamous cell carcinoma_LUSC_TCGA-37-3789-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07836769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.38534
spleen	GTEx Tissue Gene Expression Profiles	1.0	1.31896
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TC-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K09337184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74513
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and neck squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
bj	HPA Cell Line Gene Expression Profiles	-1.0	-1.13923
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.66366
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944369
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1471
BRD-K02802091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30582
PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CCRF-CEM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DLG4	Hub Proteins Protein-Protein Interactions	1.0	null
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
ARHGAP23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21124
mist1_22510200_pancreas_c57bl6_lof_mouse_gpl6246_gds4341	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.159866
AP2M1	MSigDB Cancer Gene Co-expression Modules	1.0	null
GSE130246_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ubiquitin-protein transferase inhibitor activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K38510068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65585
rhoa	Phosphosite Textmining Biological Term Annotations	1.0	null
oocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.275444
germ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220604
H3K79me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A6I3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE137144_4_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-O5YT-0126-SM-48TBW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940501
alimentary canal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K45569026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01574
regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72762
BCL3-23251550-MUSCLE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZEB1	ENCODE Transcription Factor Targets	1.0	null
BRD-K86986621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0613
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YAPC	CCLE Cell Line Gene CNV Profiles	1.0	1.48374
JUND_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mental depression	GWASdb SNP-Disease Associations	1.0	0.467446
MEC1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.24891
UBC13-UEV1A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.415
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Foxn1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.8201
PRPF8	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K96619480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01015
OE-31-YC41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.364029
BRD-K91585756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20224
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular	GeneRIF Biological Term Annotations	1.0	null
outer CP in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25474
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22059
rostral (anterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.36068
POU2F2	ENCODE Transcription Factor Targets	1.0	null
HEC108_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.01965
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
negative regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.09366
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.522405
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70568
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21118
GSE239541_11_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Hyperplasia	CTD Gene-Disease Associations	1.0	1.02821
Acute Myeloid Leukemia_LAML_TCGA-AB-2810-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2085	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.87288
GSE167886_3_v_1_chd7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13713
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19O-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SLC7A10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04884
Glomerulonephritis	DisGeNET Gene-Disease Associations	1.0	null
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.77998
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.769287
Lung adenocarcinoma_LUAD_TCGA-38-4628-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Heart ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.3
SD-69-QA40_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.379983
GTEX-U3ZH-1726-SM-3DB79	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.936203
EC-62-OE64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37116
amygdaloid complex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21749
ZFP281-18757296-E14-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ATR-ATRIP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.533
second	GeneRIF Biological Term Annotations	1.0	null
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.32412
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
HC-01-FD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224676
MUTZ5	CCLE Cell Line Gene CNV Profiles	-1.0	-1.83384
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CDK8_knockdown_88_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.62541
Perturb_8330_KO_TXNDC9_SRP141214	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
PMC9464213-41467_2022_33063_MOESM9_ESM.xlsx-BNC2_proteins-gene_name_BNC2	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTSD	Pathway Commons Protein-Protein Interactions	1.0	null
Hep-G2/2.15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.558
MTHFD1	Pathway Commons Protein-Protein Interactions	1.0	null
KNS-62	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.83861
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.983
20436685-ST5-1	GeneSigDB Published Gene Signatures	1.0	null
Bone marrow disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.578
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054464
GSE246053_4_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Renal clear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
pretectal region	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04515
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPS24	Pathway Commons Protein-Protein Interactions	1.0	null
BL2840 (UIMC1)	NURSA Protein Complexes	1.0	null
BRD-K25484053	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19989
limb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08773
GSE231648_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219542
PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MAX_WT_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.78288
MCF7_Rigosertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154957
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.024
GTEX-SJXC-0426-SM-2XCFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08728
Adipose - Subcutaneous	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.777216
EEF1AKMT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12882
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.565137
DB-56-XL71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249492
BRD-K51454545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.78114
Perturb_17751_OE_Cdk8_SRP093265	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.57407
ASNS	Pathway Commons Protein-Protein Interactions	1.0	null
negative regulation of biological process	GO Biological Process Annotations 2015	1.0	null
PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
negative regulation of histone ubiquitination	GO Biological Process Annotations 2015	1.0	null
PTK7_KD_GSE50138_674_human_H1299	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.06077
HC-74-HM63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.216471
PMC7782698-41467_2020_20367_MOESM9_ESM.xlsx-Student_s_t-test_BP1_ILK_GFP-Gene_names_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
CGTHW1	CCLE Cell Line Gene CNV Profiles	1.0	2.24974
Brain Lower Grade Glioma_LGG_TCGA-FG-A60L-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
R3HDM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14515
KAT2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08394
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Down_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08431
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36976
BRD-K73210450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57269
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.73512
PSMC6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K40876208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88425
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4284
Adrenocortical carcinoma_ACC_TCGA-OR-A5LD-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
integument	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
STING complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.528
liver	HPA Tissue Protein Expression Profiles	-1.0	-1.06423
UBE2L3	Pathway Commons Protein-Protein Interactions	1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
APEX1	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC6	ENCODE Transcription Factor Targets	1.0	null
BRD-K38248167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15979
PMC12513837-41588_2025_2336_MOESM4_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_List_of_AR-only_and_p300_AR-shared_enhancer_regulated_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.522
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.46469
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
SRF	JASPAR Predicted Transcription Factor Targets	1.0	null
hsa-miR-2861	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
PMC11385366-Table2.xlsx-DBP-Overlapped_Gene_DBP	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00513
MITF	ChEA Transcription Factor Targets	1.0	null
TAF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08334
GSE201217_4_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HSP90B1	Pathway Commons Protein-Protein Interactions	1.0	null
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.26745
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.769
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.65801
Pancreatic ductal adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.713
AR-20517297-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FAM213A	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7244323-elife-55325-supp3.xlsx-Haapaniemi_TP53-KO-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933821
GSE220520_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844041
ChIP_RNF2_22325148	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PMC3637405__F2	PFOCR Pathway Figure Associations 2023	1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328073
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33271
BRD-K57270624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28304
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SKMEL28	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49516
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A64957606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09413
Milk gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.674
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE201217_3_v_1_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATP2A2	Pathway Commons Protein-Protein Interactions	1.0	null
COX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09999
JB-48-AO57_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201364
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
ELK4_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66739
ST486	DepMap CRISPR Gene Dependency	1.0	3.15586
PIK3CG_knockdown_96_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.69916
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.64982
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inhibitor	GeneRIF Biological Term Annotations	1.0	null
PRKAB1	Hub Proteins Protein-Protein Interactions	1.0	null
BD-96-HO33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.462405
PMC12855127-Table1.xlsx-Sheet1-Table_S1_A_total_of_576_E3_genes_and_95_DUB_genes_were_identified_in_the_iUUCD_2_0_database_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
ubiquitin	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2193
vascular disease	GWASdb SNP-Disease Associations	1.0	0.128417
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836722
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.931942
ubc13-mms2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.934544
Perturb_6312_KO_MIR222_SRP073023	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.89466
TP53-23651856-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266936
ZFP281-18757296-E14-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
SIN3A	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67M-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDC73	Pathway Commons Protein-Protein Interactions	1.0	null
PSMA7	Pathway Commons Protein-Protein Interactions	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CTCF_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26584
rostral division of OFCi (area 11)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02129
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.434307
endometrial	GeneRIF Biological Term Annotations	1.0	null
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28607
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-V1D1-1926-SM-4JBGX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15703
TAF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26026
PMC8081860__F4	PFOCR Pathway Figure Associations 2024	1.0	null
NCI-H810	GDSC Cell Line Gene Expression Profiles	-1.0	-1.63501
FOXP2	ENCODE Transcription Factor Targets	1.0	null
GSE151090_5_v_3_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gemcitabine_homo sapiens_gpl96_gse6914	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K43820045	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17781
1141_CAAP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.6728
MCF7_GSK J1_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162546
tonsil	HPA Tissue Gene Expression Profiles	1.0	0.843221
UM-UC-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.745
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.23391
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Gene_Name_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
Protein kinase CK2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.622
TUBB3	Pathway Commons Protein-Protein Interactions	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.58739
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.70192
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838716
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K49298555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1072
organic cyclic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
CBM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.027
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ino80 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.099
primary visual cortex (striate cortex, area V1/17)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03444
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11083682__F2	PFOCR Pathway Figure Associations 2024	1.0	null
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19776
hsa-miR-3196	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160246_9_v_7_cpeb4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of chromosome organization	GO Biological Process Annotations 2015	1.0	null
GSE229698_1_v_2_traf7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UBE2I	MSigDB Cancer Gene Co-expression Modules	1.0	null
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73804
Intracellular ferritin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.909
ZNF257	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.6053
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
elucidating	GeneRIF Biological Term Annotations	1.0	null
BRD-K82292504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45336
VCAP	DepMap CRISPR Gene Dependency	1.0	2.01295
Perturb_3030_KO_Acta2_SRP353808	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-16.3352
cingulate gyrus, frontal part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.959355
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AQ-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE203329_0_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Urinary bladder carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89785
GTEX-X585-2426-SM-46MW2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36214
BRD-K49103797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52175
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.605688
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.14057
NELFE	ENCODE Transcription Factor Targets	1.0	null
GSE218907_3_v_2_opa1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948897
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
SCC4	CCLE Cell Line Gene CNV Profiles	1.0	1.45187
MYLA	DepMap CRISPR Gene Dependency	1.0	3.40113
BRD-K46561246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62897
RPS28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09583
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-4.61114
Cholangiocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
Stomach Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
CREB1-26743006-CHIP-SEQ-LNCAP-ABL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.69267
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.49045
anterior (rostral) cingulate (medial prefrontal) cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.847557
GTEX-UJHI-0626-SM-3DB8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28495
hsa-miR-4783-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
Brain Lower Grade Glioma_LGG_TCGA-FG-A6IZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146982_3_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94916
BRD-K79748783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09775
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5995_OTUB1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.67492
CDK2	Pathway Commons Protein-Protein Interactions	1.0	null
ELF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K04631545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11318
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-A49D-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02066524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62614
GSE119978,GSE180930_0_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EZH2-27304074-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.306716
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZP-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K59747214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15105
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.466431
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-4284	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13657
LM3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.573
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K50434315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08316
SIN3A_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU-398	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08118
MYBL2	ENCODE Transcription Factor Targets	1.0	null
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.31615
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.11592
ARTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01491
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.102
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESR1	JASPAR Predicted Transcription Factor Targets	1.0	null
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98449
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.62575
Skin Cutaneous Melanoma_SKCM_TCGA-IH-A3EA-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
8405_SRFBP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07927
ubiquitin protein ligase binding	GO Molecular Function Annotations 2015	1.0	null
negative regulation of response to dna damage stimulus	GO Biological Process Annotations 2015	1.0	null
GTF3C4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K20110031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07641
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.859
KLM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05332
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30213
PRDX2	Pathway Commons Protein-Protein Interactions	1.0	null
Myeloma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.327
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43136
Bone cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.592
Brain Lower Grade Glioma_LGG_TCGA-HT-8558-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36486
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETHE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98147
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163955
BRD-K14216093	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31494
CLTC	Pathway Commons Protein-Protein Interactions	1.0	null
Legionnaires' disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.302
MDAMB361	DepMap CRISPR Gene Dependency	1.0	3.2365
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PTPN7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00545771
Lysosomal storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
HCT 116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.526972
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0109
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
lufenuron	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77124
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYCN-27167114-CHIP-SEQ-NEUROBLASTOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.568
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.17118
GSE120612_4_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PA-TU-8988T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14023
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041916
Colorectal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.608
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.098
PFDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2241
scissile	GeneRIF Biological Term Annotations	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.829966
abnormality of blood and blood-forming tissues	GWASdb SNP-Phenotype Associations	1.0	0.078106
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Spear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.52
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Esophageal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K66179451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7509
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.850146
PMC4046519__F4	PFOCR Pathway Figure Associations 2024	1.0	null
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MERO83	DepMap CRISPR Gene Dependency	1.0	2.27633
SCCOHT1	DepMap CRISPR Gene Dependency	1.0	3.85647
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75456
REST_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDK8_knockdown_128_GSE30815	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.72932
H4K20me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KBM-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.556
alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08481
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.848
active	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8869442__F2	PFOCR Pathway Figure Associations 2024	1.0	null
KDM1A	Pathway Commons Protein-Protein Interactions	1.0	null
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.268
PMC9174176-41467_2022_30924_MOESM6_ESM.xlsx-OC2-SYMBOL_ONECUT2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TE-15-RO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.401591
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	147.316
TAGLN2	Pathway Commons Protein-Protein Interactions	1.0	null
EE-03-SG02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481181
IkappaB kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.482
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18893
Perturb_10929_OE_miR378_SRP227956	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.44109
TAB1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K78873216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23254
dorsolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.846861
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.55943
HAND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.36826
Oligospermia	CTD Gene-Disease Associations	1.0	1.26421
NRG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0102295
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hematopoietic system disease	GWASdb SNP-Disease Associations	1.0	1.32349
BRD-K28433349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81144
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.36843
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE231799_2_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.27895
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.619
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.553002
MDH2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865544
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8409-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K66416915	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21906
GSE252864_0_v_3_smad4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7764163__F2	PFOCR Pathway Figure Associations 2024	1.0	null
JHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844684
tnfdependent	GeneRIF Biological Term Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A9-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.8544
SP in entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0152
ventrolateral prefrontal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.872951
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal motor nucleus of the vagus (vagal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20802
Bacteroid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.577
Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K13804959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30038
GTEX-WRHU-0826-SM-3MJFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02115
BRD-K88274759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03124
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.244
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.860162
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.06032
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38744
UBE2V2	Pathway Commons Protein-Protein Interactions	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NAT10	Pathway Commons Protein-Protein Interactions	1.0	null
FHIP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02862
YY1_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6455_PLK4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.523975
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
biochemical	GeneRIF Biological Term Annotations	1.0	null
central nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02502
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE164463_0_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-N7MS-0011-R3a-SM-33HC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72092
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.838491
GSE149264,GSE149267_4_v_1_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-28-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-8043-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72063
CRCGN015_HEPG2_48H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.16053
PATU8988T	CCLE Cell Line Gene Expression Profiles	1.0	1.66147
SMAD2	Pathway Commons Protein-Protein Interactions	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
TNFRSF25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00462675
Primary T cells from cord blood	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	2.14904
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
pancuronium bromide-2909	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K41189799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35269
fusome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.973714
ubc13	GeneRIF Biological Term Annotations	1.0	null
GSE211983_1_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Coelomocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.504
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE231648_4_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K33787033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20078
REST_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
eye	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
PMC4046519__F4	PFOCR Pathway Figure Associations 2023	1.0	null
NR2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6819
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.30464
BRD-K48782834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11471
MDST8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02492
BRD-K90480740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57833
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHEMBL513147	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.53
BRD-K99302735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05996
hippocampus (hippocampal formation)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.62425
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.42597
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48574
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TemporalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.36922
estradiol_homo sapiens_gpl570_gse16683	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPS10	Pathway Commons Protein-Protein Interactions	1.0	null
EP300_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.051
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.848138
UBE2D3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE137144_3_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tgfbeta	GeneRIF Biological Term Annotations	1.0	null
negative regulation of protein polyubiquitination	GO Biological Process Annotations 2015	1.0	null
MCF7_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.015359
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.0449
lm13	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
finger	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.324605
A549_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168846
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.98953
BRD-K89377615	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6032
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.538039
BRD-K78618254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2963
doxorubicin_homo sapiens_gpl10558_gse42531	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
infection	Phosphosite Textmining Biological Term Annotations	1.0	null
endometrial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.440658
BRD-K45628030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06004
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124410_6_v_0_stk40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-08-SZ54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267512
HEK-293T cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.689
BRD-K95443593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01247
BRD-K24382357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10511
Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11173
outer CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.912347
DSTN	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861185
BRD-K59402582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03013
Lung squamous cell carcinoma_LUSC_TCGA-22-4607-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
endogenous depression	GWASdb SNP-Disease Associations	1.0	0.930169
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900748
GARS	Pathway Commons Protein-Protein Interactions	1.0	null
cellular response to stimulus	GO Biological Process Annotations 2015	1.0	null
ALDOC	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K63743653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37934
Stomach Smooth Muscle	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.01384
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.12146
cell lysate	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.242983
PC-14	GDSC Cell Line Gene Expression Profiles	1.0	1.56711
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K46824282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3904
NAGPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04774
SF-21 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.678
GTEX-O5YW-0126-SM-3LK6D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01706
ratio	GeneRIF Biological Term Annotations	1.0	null
deferasirox_homo sapiens_gpl570_gds3558	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE104022_3_v_7_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
tobramycin-2481	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-genes_with_unique_SNP-F5-Pneo-r__CIC-1n_h-r__CIC-2n_h-r_CIC	Rummagene Transcription Factor Associations 2026	1.0	null
GSE142210_2_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
either	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47W-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9491
TIMM44	Pathway Commons Protein-Protein Interactions	1.0	null
HOP92	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.924161
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_0_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197547
STARD3NL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42657
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337363
GABPA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RARB-27405468-CHIP-SEQ-BRAIN-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
smad3	GeneRIF Biological Term Annotations	1.0	null
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.242672
Bile duct disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
A549_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013326
CRCGN010_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22452
H3K79me2_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.967919
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
manipulating	GeneRIF Biological Term Annotations	1.0	null
MFE319_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	7.04023
GSE62843,GSE64371_2_v_3_furan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MEF2A	JASPAR Predicted Transcription Factor Targets	1.0	null
bond	GeneRIF Biological Term Annotations	1.0	null
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
JF-96-HH81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245161
Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Xylanosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.355
BRD-K76723780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47721
blood vessel	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13058
ADD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28738
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA-68-KG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206103
regulation of cellular component organization	GO Biological Process Annotations 2015	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M8-01A-21R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LV-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_3H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0823
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5601
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.426
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
TDRD3-21172665-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
USP5	MSigDB Cancer Gene Co-expression Modules	1.0	null
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_6056_KD_QKI_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SPSB1	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K82968105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51959
Damo	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.389
decreased bone mineral content	MGI Mouse Phenotype Associations 2023	1.0	null
FIS1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE154577_2_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100390_PCx_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.05411
BT549	DepMap CRISPR Gene Dependency	1.0	2.27533
NR2C2	ENCODE Transcription Factor Targets	1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00226
extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE144796_1_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.089724
PMC8104016-hcg-12-e002353-s006.xlsx-mTHP-1-LPS_Prom-Distal-RefSeq_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.56411
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.1552
GTEX-T8EM-0826-SM-4DM76	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851953
enrichment culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.913507
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
organelle	GO Cellular Component Annotations 2015	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.946431
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.931769
sirna	GeneRIF Biological Term Annotations	1.0	null
G6PD	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Selisistat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148353
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE169205_3_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHRNA10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35723
dna	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.442
BRD-K63163033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28492
GSE211286_4_v_6_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Germarium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.834
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNFX1	Pathway Commons Protein-Protein Interactions	1.0	null
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K53889798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29354
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
mms2	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-3139	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826148
GTEX-XQ3S-1526-SM-4BOOC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00842
HOP-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15467
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.43944
GTEX-QDT8-0011-R10A-SM-32PKG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25132
BRD-K41433616	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66467
ubiquitin-like protein peptidase activity	GO Molecular Function Annotations 2025	1.0	null
PMC12695649-41588_2025_2389_MOESM2_ESM.xlsx-GATA6_RIME-_AsPC-1-Gene_Symbol_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K33200274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29251
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03247
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053118
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99777
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27956
hsa-miR-940	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K26402831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09544
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
EBNA1BP2	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-28-5p	MiRTarBase microRNA Targets	1.0	null
BRD-K95338817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08653
Oral squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.348
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ModE complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.604
FA-39-KG56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.343253
BRD-K21935128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67143
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UTHO-2926-SM-3P5Z9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33043
PMC8225676-41467_2021_24150_MOESM4_ESM.xlsx-DUB_ranking_siRNA_screening-DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Clear cell adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
zygote	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.33046
genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.046297
FLNB	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH2110	CCLE Cell Line Gene Expression Profiles	-1.0	-2.02183
Nasopharynx carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03724
BRD-K04786080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21291
CREB1-26743006-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355544
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K74676765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37558
WM3772F	DepMap CRISPR Gene Dependency	1.0	2.10857
NFATC1	ENCODE Transcription Factor Targets	1.0	null
MCF7_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150369
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	167.996
GTEX-S7PM-0126-SM-4AD6S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862637
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.74012
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.97739
Hrd1p ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.831
OPA1	Pathway Commons Protein-Protein Interactions	1.0	null
SUM149PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.691847
SK-MEL-28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.24805
amygdaloid complex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.903679
Ebolavirus(EBOV)_2day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.00542
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.843
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PANC0327	DepMap CRISPR Gene Dependency	1.0	2.20675
posttranslational	GeneRIF Biological Term Annotations	1.0	null
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE169571_0_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00576
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44132
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
uptake	Phosphosite Textmining Biological Term Annotations	1.0	null
IPO7	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K40306365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17687
NCI-H1395	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6606
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A763-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K42455540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32711
Lung squamous cell carcinoma_LUSC_TCGA-43-6771-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fibrosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.088
GSE158815_1_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.538
HB-24-GP45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2297
BRD-K88542817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21454
intracellular part	GO Cellular Component Annotations 2015	1.0	null
doublestrand	GeneRIF Biological Term Annotations	1.0	null
SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.3685
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymph node	HPA Tissue Gene Expression Profiles	1.0	0.922251
uterine adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.569622
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01812
virustriggered	GeneRIF Biological Term Annotations	1.0	null
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955226
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.2945
SIN3A-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.797
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934356
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K77884956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31651
DE-73-JX23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21765
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A556-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XY-0626-SM-4E3IN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50225
Perturb_3090_KO_Gb6_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.73576
GTEX-T6MN-0126-SM-32PLP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965479
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A69950438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00355
BRD-K77401804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02973
GSE190384,GSE190386_2_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
SA1-27219007-CHIP-SEQ-ERYTHROID-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE210655_1_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ARAF	MSigDB Cancer Gene Co-expression Modules	1.0	null
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSPA8	Pathway Commons Protein-Protein Interactions	1.0	null
Multiple myeloma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.232
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14044
FHC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.733
PMC6828713__F1	PFOCR Pathway Figure Associations 2024	1.0	null
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
ZNF81	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72418
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.033
coopts	GeneRIF Biological Term Annotations	1.0	null
BRD-K96560179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52271
Prostate adenocarcinoma_PRAD_TCGA-J4-A67S-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABPA_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TPR	MSigDB Cancer Gene Co-expression Modules	1.0	null
COP9 signalosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.786
GSE206270_1_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ML1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36341
GTEX-QLQW-0126-SM-447BK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937869
C4I	DepMap CRISPR Gene Dependency	1.0	2.1061
JUN-27471255-CHONDROCYTES-MOUSE-RIB	ChEA Transcription Factor Targets 2022	1.0	null
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USP15	Pathway Commons Protein-Protein Interactions	1.0	null
NIF3L1	Pathway Commons Protein-Protein Interactions	1.0	null
SPPL2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482851
MAZ_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.914089
GSE60837_0_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
NCIH650	CCLE Cell Line Gene CNV Profiles	1.0	1.34476
C2BBe1	GDSC Cell Line Gene Expression Profiles	1.0	1.45949
WM-266-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.944
BRD-K43680691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01657
PMC5848610-supp_gr.228809.117_Supplemental_Table_S3.xlsx-Table_S3F-Supplemental_Table_S3F_ZFX_binding_pattern_clustering_information_for_genes_with_promoters_bound_by_ZFX_related_to_Figure_2I_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
DOK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1347
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A6I0-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FKBP1A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.1623
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10501
HCT-116 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.655
OB-06-WW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305186
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962572
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.939503
BRD-K98757606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26133
TEX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40798
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18436
GSE137144_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZACN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0053472
A549_SRT2104_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163722
cellular aromatic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
CEBPB-24764292-MC3T3-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K73459389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23896
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01203
RAD21	ENCODE Transcription Factor Targets	1.0	null
Cco	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.796
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.018
TRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
SW954	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
NANOG_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN015_HEPG2_48H:P13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46621
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2022
DNM1L	Pathway Commons Protein-Protein Interactions	1.0	null
TGFBR1_knockdown_102_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.64413
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMED10	Pathway Commons Protein-Protein Interactions	1.0	null
LASV_FML29_24hr_24069471_GSE41300	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.674471
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.54186
Cul2-RING ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.072
BRD-K81515704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42269
Cystic fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
PMC6436215-13073_2019_626_MOESM2_ESM.xlsx-NCM-RORA_RORA	Rummagene Transcription Factor Associations 2026	1.0	null
PCNA	Pathway Commons Protein-Protein Interactions	1.0	null
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.464243
inferior frontal gyrus, triangular part, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.929357
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.206039
MXI1	ENCODE Transcription Factor Targets	1.0	null
7559_RRN3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.541797
Sarcoma_SARC_TCGA-IS-A3K7-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201239_6_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.62682
depression	GWASdb SNP-Phenotype Associations	1.0	0.81905
RT112	CCLE Cell Line Gene Expression Profiles	1.0	1.53205
RPA2	MSigDB Cancer Gene Co-expression Modules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-5965-02B-11R-A29R-07,TCGA-FG-5965-02A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48181
BRD-K34106082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82944
H3K79me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PL4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-4.45367
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ocular cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055716
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
clozapine_mus musculus_gpl339_gse6467	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE188570,GSE188571_3_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_3_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCDC88C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25826
PMC11699082-BLOODA_ADV-2023-012291-mmc1.xlsx-Sheet1-CD37_pos_corr_top100_GSE10846_CHOP_ABC_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.830991
YY1-26981420-C2C12-MOUSE-MUSCLE	ChEA Transcription Factor Targets 2022	1.0	null
Cus cation efflux complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.663
CHD7	ENCODE Transcription Factor Targets	1.0	null
PMC10216727__F2	PFOCR Pathway Figure Associations 2024	1.0	null
AB-92-GP61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328082
Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_330_KD_MCM7_SRP258965	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.83464
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.769067
GTEX-O5YT-0926-SM-48TDG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08985
increased cornea thickness	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K63584084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1858
GTEX-XGQ4-0426-SM-4AT4I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896433
lys48	GeneRIF Biological Term Annotations	1.0	null
BRD-K50114736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12441
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.21331
GSE142019,GSE142021_10_v_3_ythdf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CREB1	ENCODE Transcription Factor Targets	1.0	null
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01666
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.375743
PMC4777381-pone.0150624.s007.xlsx-dif_exp_AD-ZBTB38_ZBTB38	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H2023	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.940178
vincristine_rattus norvegicus_gpl1355_gse19290	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TANK	Pathway Commons Protein-Protein Interactions	1.0	null
sense organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
eukaryotic translation initiation factor 2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.238478
YY1	ChEA Transcription Factor Targets	1.0	null
testis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.378372
A498	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37369
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.20768
HCC1395	CCLE Cell Line Gene CNV Profiles	1.0	1.46313
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6870-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A61V-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47896
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.444482
Renal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.017
EIF4G3	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_liver_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.8519
esophagus_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.865488
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845072
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26089
Arm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.994
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S7PM-0011-R6A-SM-3NM8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27779
COMPOUND 61 [PMID: 36221183]	DGIdb Drug Targets 2026	1.0	17.644
KIAA0368	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreas	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.874759
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
cellular protein modification process	GO Biological Process Annotations 2015	1.0	null
Nasopharyngeal carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.905
PMC11827247-41065_2025_387_MOESM5_ESM.xlsx-Sheet_1-Only_ESR_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
Aggresome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.179
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
nfkappab	GeneRIF Biological Term Annotations	1.0	null
BRD-K06002536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6449
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.762818
artery	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K87929769	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38317
Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13011
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45443
BRD-K39985369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22897
BRD-K55218521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17588
AC-55-XA97_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211221
distinct	GeneRIF Biological Term Annotations	1.0	null
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.55
STAMBPL1	Pathway Commons Protein-Protein Interactions	1.0	null
sites	GeneRIF Biological Term Annotations	1.0	null
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.537
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963103
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.876
CRCGN016_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59676
Heterocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.055
hsa-miR-3180-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
clidinium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76006
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACTB	Pathway Commons Protein-Protein Interactions	1.0	null
fisetin-579	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SIU8-0126-SM-2XCDT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907922
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6436-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K72602058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21917
Medial geniculate nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.431
GTEX-OHPL-1026-SM-3MJGI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15122
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC9612852__F2	PFOCR Pathway Figure Associations 2024	1.0	null
Rectal Mucosa Donor 31	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.04881
GTEX-PVOW-0011-R1A-SM-32PL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26818
ZBTB7A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decreased grip strength	IMPC Knockout Mouse Phenotypes	1.0	null
infection	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5424
PSMC1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11040904__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
RPS27A	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K69536411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3694
BRD-K34954550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04342
GSE188570,GSE188571_3_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.921122
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.31867
PMC3094536-12013_2011_Article_9176.nxml--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.31557
BRD-K07551625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23482
FF-22-NB12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279012
CTCF	ENCODE Transcription Factor Targets	1.0	null
BRD-K35176035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65519
CTTN	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K02106348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31715
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8593586-mmc2.xlsx-LIN28A_interactome-Unnamed_1_LIN28A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE191105_2_v_3_nat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRDX1	Pathway Commons Protein-Protein Interactions	1.0	null
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.566
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92442
GSE94814_2_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111881_0_v_1_znf768_human	RummaGEO Gene Perturbation Signatures	1.0	null
Endometrial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.125
GSE203308_14_v_0_brf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
damage	GeneRIF Biological Term Annotations	1.0	null
GABPA_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.654
BRD-K89806367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01031
PMC7911352__F2	PFOCR Pathway Figure Associations 2023	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
protein deubiquitination	GO Biological Process Annotations 2023	1.0	null
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36735
A549_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0214759
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968196
sirolimus_homo sapiens_gpl96_gds2494	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4692	TargetScan Predicted Conserved microRNA Targets	1.0	0.085563
Nitrate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.945
KNS60	CCLE Cell Line Gene Expression Profiles	-1.0	-2.83803
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5F-Up_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBA1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
debrisoquin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10226
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4335
PMC11141901-jciinsight-9-166505-s172.pdf-18-FOXP1_FOXP1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51676
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.873638
SCF ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.558
GTEX-WWYW-1326-SM-3NB2S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07458
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.497266
GSE239844_8_v_0_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-N-AS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.3403
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297783
EE-08-SZ54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264864
BRD-K73475697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16356
BRD-K70087673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02798
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.8658
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
methotrexate_homo sapiens_gpl571_gse9412	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.63482
Rumen epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.572
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.795
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SW1573	CCLE Cell Line Gene Expression Profiles	-1.0	-1.76814
BRD-K54099984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59291
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21959
BRD-K77578964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39649
FNBP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05118
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JS-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCILY19	DepMap CRISPR Gene Dependency	1.0	3.79843
GSE252988_0_v_1_lefamulin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9820089-ijms-24-00552.nxml--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-8402-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.97739
PMC4944136-srep28995-s2.xls-NOBOX-gene_NOBOX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K90358614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15339
DUBm complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.254
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
COLO678	CCLE Cell Line Gene CNV Profiles	1.0	1.5077
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCAS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Root tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.005
GSE139427_2_v_1_ibrutinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE240027,GSE240030_5_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166315_1_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF7_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.844246
Fumarate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.275
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.24052
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
colon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
decreased bone mineral content	IMPC Knockout Mouse Phenotypes	1.0	null
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053421
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08754
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86872
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
2783_EXOC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.531281
GSE198165,GSE198166_9_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
regulation of double-strand break repair	GO Biological Process Annotations 2023	1.0	null
FOSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01115
Fanconi anaemia nuclear complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
regulation of dna repair	GO Biological Process Annotations 2015	1.0	null
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mucilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
BRD-K36368568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13884
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71343
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1	ChEA Transcription Factor Targets	1.0	null
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57726
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal cranium morphology	IMPC Knockout Mouse Phenotypes	1.0	null
CRCGN015_MCF10A_48H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0512
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPN-0011-R2A-SM-2I5FB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35245
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K23404017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46251
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-5631-01A-01R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10976
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.995
S1PR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3859
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.268
ERA-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24558
AB-71-CI37_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.853673
regulation of dna metabolic process	GO Biological Process Annotations 2015	1.0	null
Tonsil	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.268
dorsolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.91458
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC48A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13611
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Carcinoma, Ovarian Epithelial	DisGeNET Gene-Disease Associations	1.0	null
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.834
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.867067
A549_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0264183
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.459
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC-19030024-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.9687
Mouth	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.268
PIGG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06614
negative regulation of double-strand break repair	GO Biological Process Annotations 2025	1.0	null
QB-99-OU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.51319
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal cranium morphology	MGI Mouse Phenotype Associations 2023	1.0	null
posteroventral (inferior) parietal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10555
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.726
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.694649
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
butoconazole-2427	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Gall bladder cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.663
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.5314
PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_402_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.885046
traf3	GeneRIF Biological Term Annotations	1.0	null
UBE2N	Pathway Commons Protein-Protein Interactions	1.0	null
PSMD2	Pathway Commons Protein-Protein Interactions	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
negative regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
Pancreatic ductal adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.182
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.12215
ubiquitin-specific protease activity	GO Molecular Function Annotations 2015	1.0	null
PMC9314667-Table_1.xlsx-Regulons-FOSL1_FOSL1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
EGR1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endometrioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.539
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A77O-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
increased cornea thickness	IMPC Knockout Mouse Phenotypes	1.0	null
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0184
AE-42-HT01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.469052
PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_WT_TESTES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
Rumen	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.703
BRD-K65494150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91734
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.880826
PMC3756857-12013_2013_Article_9635.nxml--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
CLTCL1	Pathway Commons Protein-Protein Interactions	1.0	null
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.402
GSE90754_0_v_1_foxo1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HS 294T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844684
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
PMC10061014-Table5.XLSX-C_vs_LD-Table_S5c_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_DEX_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.876
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.78175
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K30283890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38015
receptorassociated	GeneRIF Biological Term Annotations	1.0	null
MCF7_BRD4770_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140399
Bile duct carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
PBX3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
P63-20808887-KERATINOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPJH-0126-SM-4IHLL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14179
FARAGE	DepMap CRISPR Gene Dependency	1.0	4.10168
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OL-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.102874
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39121
H3K79me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.875096
VENTX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7465
excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Golgi-associated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.213
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
P12ICHIKAWA	CCLE Cell Line Gene CNV Profiles	1.0	2.88614
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ubiquitin conjugating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.993183
PSMD6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K29702569	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87118
EEF1A2	Pathway Commons Protein-Protein Interactions	1.0	null
Endoplasmic reticulum Sec complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.68
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Secondary Malignant Neoplasm Of Liver	DisGeNET Gene-Disease Associations	1.0	null
overexpression	GeneRIF Biological Term Annotations	1.0	null
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946327
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.899274
RPS6KB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40833
enzyme	GeneRIF Biological Term Annotations	1.0	null
DDX19B	Hub Proteins Protein-Protein Interactions	1.0	null
XRCC6	Pathway Commons Protein-Protein Interactions	1.0	null
GSE144346_0_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ABCF1	Pathway Commons Protein-Protein Interactions	1.0	null
Primary root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.929
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02557
RELA	ENCODE Transcription Factor Targets	1.0	null
antiviral	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Esophageal squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.175
Adrenocortical carcinoma_ACC_TCGA-OR-A5LE-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05413
GSE193993_4_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.891067
GABPA_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UGDH	Pathway Commons Protein-Protein Interactions	1.0	null
DDX3X	Pathway Commons Protein-Protein Interactions	1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.853
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33628
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K95591629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02817
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02124
TOMM40L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18633
Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PDGFRA_knockdown_117_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.62838
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.50067
ubiquitin-like protein peptidase activity	GO Molecular Function Annotations 2023	1.0	null
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04786
Legionellosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
A549_Ki8751_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153053
deubiquitinating	GeneRIF Biological Term Annotations	1.0	null
Colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.25
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.84667
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
modulating	GeneRIF Biological Term Annotations	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K36me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HM13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00646714
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.0184
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FD-59-TC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20443
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K61821542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55555
cisplatin_homo sapiens_gds3910	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K52859120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8482
Congenital hypoplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.521
Bone marrow cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.583
PMC8572460__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.289
Right atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.193
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	156.58
PMC8526018-KAUP_A_1856493_SM1378.xlsx-Table_S5-_DUB_genes-Table_S5_Compared_deubiquitinating_enzyme_genes_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276794
HPAF-II	GDSC Cell Line Gene Expression Profiles	1.0	1.49333
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965326
BRD-K80469338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.433
TFAP2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.052486
EFM-19	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25631
HCC1143_BREAST	CCLE Cell Line Proteomics	1.0	2.11824
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28542
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	3.2403
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.02971
GSE153871_5_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SELENBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06409
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K75529374	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08571
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.30605
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86414
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.672697
TROVE2	Hub Proteins Protein-Protein Interactions	1.0	null
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10544320-12885_2023_11428_MOESM7_ESM.xlsx-Detected_in_THP1-Mono_A549_only-Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Biliary tract cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
discriminate	GeneRIF Biological Term Annotations	1.0	null
regulation of chromatin organization	GO Biological Process Annotations 2015	1.0	null
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06767
PMC9574515-mmc2.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ITGAV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41064
Perturb_6972_OE_Cdk8_SRP102453	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.07775
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62682
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pirenperone-2455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
endometrium_8b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.905927
F5	DepMap CRISPR Gene Dependency	1.0	3.6935
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ciap1	GeneRIF Biological Term Annotations	1.0	null
substrates	GeneRIF Biological Term Annotations	1.0	null
XPC	MSigDB Cancer Gene Co-expression Modules	1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.44038
CRCGN015_HEPG2_48H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.09221
GTEX-PVOW-0426-SM-2XCF8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51277
cholecalciferol_mus musculus_gpl339_gse18993	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE169571_5_v_1_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and neck carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.21
Host cellular component	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.576
BRD-K95792127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66745
GNG11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35836
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.179752
CRCGN015_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19502
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.93286
insights	GeneRIF Biological Term Annotations	1.0	null
CE-69-HJ13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.220218
GSE202284,GSE202289_3_v_4_bmal1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
modifications	GeneRIF Biological Term Annotations	1.0	null
BRD-K62170825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11359
EIF4A3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.249227
U2OS	DepMap CRISPR Gene Dependency	1.0	2.62102
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
KU1919	CCLE Cell Line Gene CNV Profiles	1.0	1.88162
SIN3B	ChEA Transcription Factor Targets	1.0	null
placenta	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
T-24 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.985
palmatine-chloride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1908
FOS	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.738885
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSN	Pathway Commons Protein-Protein Interactions	1.0	null
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.492117
PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KALS-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.48855
LNCaP-C4-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.506
PMC7149918-12974_2020_1781_MOESM1_ESM.xlsx-Table_S7_CEBPB_Astrocyte_marker-Symbol_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
SYNE1	Pathway Commons Protein-Protein Interactions	1.0	null
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.0844
NANOG-20526341-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15958
ACTC1	Pathway Commons Protein-Protein Interactions	1.0	null
Tumor Progression	DisGeNET Gene-Phenotype Associations	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
head of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.13632
PMC9574515-mmc1.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24893
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3229
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDK5	Pathway Commons Protein-Protein Interactions	1.0	null
TRAF3	Pathway Commons Protein-Protein Interactions	1.0	null
Learning Disorders	CTD Gene-Disease Associations	1.0	1.20719
large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NCI-H28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844684
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64589
MARK2	Pathway Commons Protein-Protein Interactions	1.0	null
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.70294
Phellem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.671
EJM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.733
ZFX-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.869552
GSE142210_11_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42775
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.11407
ChIP_MYCN_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
fallopiantube_8c	HPA Tissue Sample Gene Expression Profiles	1.0	1.18005
GP1BA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00442565
TRIM21	Hub Proteins Protein-Protein Interactions	1.0	null
PMC7601648__F1	PFOCR Pathway Figure Associations 2024	1.0	null
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.319546
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
D283MED	DepMap CRISPR Gene Dependency	1.0	2.92449
BRCA1-C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.857
RCOR1	ENCODE Transcription Factor Targets	1.0	null
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.659
Sarcoma_SARC_TCGA-DX-A8BZ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12311512-mmc3.xlsx-OE_VS_NC2-Gene_Names_DR1	Rummagene Transcription Factor Associations 2026	1.0	null
15902281-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
EP300_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0726-SM-2XCF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09575
Physical disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.403
LRRC8D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22586
temporal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05261
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ER-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827397
Mitochondrial crista	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.19
hsa-miR-197	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.198
amantadine-1344	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_7057_KO_Sod2_ERP107154	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.91027
GSE121198,GSE129779_3_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IGR1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42491
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Proteasome activator complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.823
KDM5A	ENCODE Transcription Factor Targets	1.0	null
BRD-K17675924	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5215
PMC8721856__F2	PFOCR Pathway Figure Associations 2024	1.0	null
EIF1B	Hub Proteins Protein-Protein Interactions	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02186
GSE142210_3_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Secondary Malignant Neoplasm Of Lymph Node	DisGeNET Gene-Disease Associations	1.0	null
BRD-K60777422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84295
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87939000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07035
NDUFB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26569
regulation of double-strand break repair	GO Biological Process Annotations 2025	1.0	null
GSE201239_3_v_2_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HMC18	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63245
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RPL31	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6II-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
negative regulation of protein K63-linked ubiquitination	GO Biological Process Annotations 2023	1.0	null
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H1_Derived_Mesenchymal_Stem_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.854781
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TERF2IP	MSigDB Cancer Gene Co-expression Modules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67L-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IDH1	Pathway Commons Protein-Protein Interactions	1.0	null
negative regulation of protein ubiquitination	GO Biological Process Annotations 2015	1.0	null
ubiquitin-like protein binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.29104
among	GeneRIF Biological Term Annotations	1.0	null
BRD-K19168437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17057
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.03809
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.56233
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
WDR82	Pathway Commons Protein-Protein Interactions	1.0	null
GSE137144_5_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE120612_4_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
endogenous	GeneRIF Biological Term Annotations	1.0	null
Retina	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC12234789-41467_2025_61560_MOESM3_ESM.xlsx-Supplementary_data_1-Only_YY1_IP-MS_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054606
HN	GDSC Cell Line Gene Expression Profiles	1.0	1.80764
Caov-3	GDSC Cell Line Gene Expression Profiles	1.0	2.06246
TAL1	ENCODE Transcription Factor Targets	1.0	null
CDK6_knockdown_93_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.49859
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19693
BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GE-58-RW27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286648
PMC9378837-Table_3.xlsx-Venn_Diagram_Upstream_regulat-180_elements_included_exclusively_in_ESR1_Upstream_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13648
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213632_3_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GCH1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.639
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54303
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28813
embryoday6.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.00516
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827619
TUBB	Pathway Commons Protein-Protein Interactions	1.0	null
SNU626	DepMap CRISPR Gene Dependency	1.0	2.16467
GSE228181_2_v_1_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1909	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
FOXF2	JASPAR Predicted Transcription Factor Targets	1.0	null
BRD-K62935946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05193
JHOC5	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20311
BRD-A91461229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80854
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TNPO2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN008_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28255
temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K70428675	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19695
HSPH1	Pathway Commons Protein-Protein Interactions	1.0	null
Biliary tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37258
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.862314
BRD-K61134709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06247
TUBB1	Pathway Commons Protein-Protein Interactions	1.0	null
EJM	DepMap CRISPR Gene Dependency	1.0	2.03767
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
USP9X	Pathway Commons Protein-Protein Interactions	1.0	null
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28973
Plasmacytoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.6
PMC10153265-media-3.xlsx-BENPORATH_NANOG_TARGETS_v2023_1-STANDARD_NAME_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
cefalexin-1273	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_8-ILL1_T_Cells_FOXP3_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184479_3_v_2_aim2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K01980291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18167
TNFSF12	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9225015-elife-72879-supp6.tsv--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE147056_4_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100573_HIP_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.21901
FUS	Pathway Commons Protein-Protein Interactions	1.0	null
Site of double-strand break	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.484
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.844645
BRD-K30799912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11634
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trifluoperazine-2389	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CLIC1	Pathway Commons Protein-Protein Interactions	1.0	null
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.31543
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05405
cytoplasm	LOCATE Predicted Protein Localization Annotations	1.0	null
PFKP	Pathway Commons Protein-Protein Interactions	1.0	null
TCF3	ENCODE Transcription Factor Targets	1.0	null
CTCF_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76173551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09906
positive regulation of TOR signaling	GO Biological Process Annotations 2025	1.0	null
GTEX-R55E-2526-SM-2TC6H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48409
HUPT3	DepMap CRISPR Gene Dependency	1.0	2.95624
GSE211931_0_v_3_ncoa4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
major depressive disorder	GWASdb SNP-Disease Associations	1.0	0.930169
promoting	GeneRIF Biological Term Annotations	1.0	null
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8747
AA-52-JS03_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204422
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.82825
B-lymphocyte	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.851022
germarium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.70843
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Zfx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	67.6953
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.47182
immune system disease	GWASdb SNP-Disease Associations	1.0	0.083838
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
MCF7_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0112645
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30934
BRD-K22316029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.46033
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46792
NCIH526	CCLE Cell Line Gene Expression Profiles	1.0	1.80724
gastrointestinal tract	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.534258
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.93423
Alate adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
biological regulation	GO Biological Process Annotations 2015	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A5VM-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KCNK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87224
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341379
OCT4-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TRIM28	Pathway Commons Protein-Protein Interactions	1.0	null
COV434	DepMap CRISPR Gene Dependency	1.0	2.15998
BRD-K54317642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.154
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.865
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.24087
cardiovascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE235945_1_v_0_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845338
GTEX-UPK5-0226-SM-3GAEV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965614
GM2313	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.37441
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ebolavirus(EBOV)_5day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.66106
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0371
fetus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
MDAMB175VII	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51421
BRD-K61248288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05731
SNU-387	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844684
PABPC1	Pathway Commons Protein-Protein Interactions	1.0	null
Cul3-RING ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.909
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.4093
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01949
EP300	ENCODE Transcription Factor Targets	1.0	null
MCF7_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0116334
UBD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00708735
ablation	GeneRIF Biological Term Annotations	1.0	null
H3K36me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YT-1026-SM-3MJGF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9443
CE-95-YX02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.301941
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7576810-41419_2020_3099_MOESM9_ESM.xlsx-MS_analysis_EVI1-WT_vs_EVI1-S43-Unnamed_0_MECOM	Rummagene Transcription Factor Associations 2026	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27627
SQ1	CCLE Cell Line Gene Expression Profiles	1.0	1.45646
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3835
ELF1-20517297-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20684
lymphnode_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.62876
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.943254
immune system process	GO Biological Process Annotations 2015	1.0	null
PMC9225015-elife-72879-supp6.tsv--DUB_HUGO_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RXR-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Zfp961	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.4422
RYR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20516
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.341126
BRD-A31602150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74596
PRDX6	Pathway Commons Protein-Protein Interactions	1.0	null
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLHDC8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61961
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.847233
NELFA-20434984-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
concentration	GeneRIF Biological Term Annotations	1.0	null
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3951
BRD-K53095870	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91791
GSE158834_0_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.2643
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
posterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.983449
inhibited	GeneRIF Biological Term Annotations	1.0	null
BRD-K42465630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18821
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864322
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2739
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.30979
GSE175787_5_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE186223,GSE186224_6_v_3_hmces_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988474
SSBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE146982_4_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_DMAP1_20946988	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-WFG8-0726-SM-3GILP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39129
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.42203
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.55
LIVF001-016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77502
A549_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140488
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.451154
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.914599
POLR2AphosphoS2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.185469
ondansetron-6153	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846401
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K77214724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92164
JARID1A-20064375-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
3291_GATA1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.571299
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.530551
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0878
BRD-K72661036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27231
GTEX-VJYA-1326-SM-3GIJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863608
SUMO2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
Thyroid cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.64561
NCKIPSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61357
DHX29	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875734
BRD-K18109695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07766
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K89094496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22126
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.7067
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CP in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.941946
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.13089
EGR1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S12_LF_C1_8h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.965
Kidney Chromophobe_KICH_TCGA-KL-8345-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_8504_KO_Hr_SRP200420	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.03852
SEC22B	Pathway Commons Protein-Protein Interactions	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.88479
FAR/SIN/STRIPAK complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.784
GSE155852_0_v_1_apigenin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013515
BCL3	ChEA Transcription Factor Targets	1.0	null
PA-TU-8902	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.872514
fallopian tube	HPA Tissue Gene Expression Profiles	1.0	1.24103
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27944
PMC4441763__F4	PFOCR Pathway Figure Associations 2023	1.0	null
TTR	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12363
19036130-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-3607-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
CRCGN015_HEPG2_48H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4909
BRD-K34604637	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23367
regulation of double-strand break repair	GO Biological Process Annotations 2015	1.0	null
BL2158 (USP34)	NURSA Protein Complexes	1.0	null
Normocytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
serine-tRNA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.081
P4HB	Pathway Commons Protein-Protein Interactions	1.0	null
Cerebellar disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.066
CAND1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE179531_1_v_0_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
nitrofural-2459	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
OB-15-UL37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208328
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-342-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.31417
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
EB-09-OC36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230901
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
KA-71-CQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.532943
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC3999155__F6	PFOCR Pathway Figure Associations 2023	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZB-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.321277
MCF7_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123872
GSE158834_10_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SF539	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2435
BRD-K31977946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02761
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275001
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.59241
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084641
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29406
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5175-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-548z	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.722697
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0123471
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K61439686	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2553
colon	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-2.52687
CHD2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9225015-elife-72879-supp5.tsv--DUB_HUGO_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.06797
GSE102486,GSE102490_1_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hereditary ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.075
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3654
BRD-K14255526	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40414
HMEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.03666
Esophageal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.368
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.53553
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.9937
Mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.363
Ebf4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.5485
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.06024
vesicle	GO Cellular Component Annotations 2015	1.0	null
Proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.621
hsa-miR-548ac	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
BRD-K46407773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32084
EIF1B	Pathway Commons Protein-Protein Interactions	1.0	null
KRT19	Pathway Commons Protein-Protein Interactions	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36122
GTEX-S7PM-0011-R5A-SM-3NM8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74368
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BCL6-25482012-CML-JURL-MK1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF586	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1086
TBP	ENCODE Transcription Factor Targets	1.0	null
RFX5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF214	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8212
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5018
forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Hypertrophy	CTD Gene-Disease Associations	1.0	1.18554
H2AB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07469
VCAP	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
GSE104022_1_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
TP63-30713093-EPITHELIAL-HUMAN-TONGUE-SCC	ChEA Transcription Factor Targets 2022	1.0	null
COX5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17504
BRD-K44684577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10893
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450849
Lung squamous cell carcinoma_LUSC_TCGA-60-2719-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M8-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFP91	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20126
integument	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.947537
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7862630__F3	PFOCR Pathway Figure Associations 2024	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
NDFIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2326
K562_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163337
RNF31	Pathway Commons Protein-Protein Interactions	1.0	null
FA-63-WI26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204332
PMC12354803-42003_2025_8643_MOESM2_ESM.xlsx-2w_TP63_positive-Gene_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
plicamycin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75654
KDM2B-26808549-CHIP-SEQ-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.843072
ALG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01504
Osteosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.602
BRD-K47878187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42339
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TIMM23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.74973
PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K75330923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47147
Autoimmune disease of gastrointestinal tract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Y-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14023
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00987
BRD-K48691513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2085
MCF7_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157667
K562_ZM 447439_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160577
BRD-K67905771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8483
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.579
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18160665-TableS5	GeneSigDB Published Gene Signatures	1.0	null
MOR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.941284
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CAR-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12315
TEAD4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG	ENCODE Transcription Factor Targets	1.0	null
GTEX-WFG8-1826-SM-4LVM4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08434
Axillary bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.078
Husk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6155-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K46400317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16544
BRD-A61864215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71135
BRD-K91039552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82857
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P7-A5NX-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GATA1-19941826-K562-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
HCMV_24Hour-anti_EGFR_treatment_20173022_GSE17948	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.54049
NME2	Pathway Commons Protein-Protein Interactions	1.0	null
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-S4P3-0626-SM-4AD59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957982
ZNF736	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02988
PMC7149918-12974_2020_1781_MOESM1_ESM.xlsx-Table_S7_CEBPB_Astrocyte_marker-Ensembl_ID_CEBPB	Rummagene Transcription Factor Associations 2026	1.0	null
TrigeminalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.04455
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04785
Encephalomyelitis	DisGeNET Gene-Disease Associations	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BT-483	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876173
A549_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151088
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-5.44465
EEF1G	Pathway Commons Protein-Protein Interactions	1.0	null
PMC3371315-NIHMS350140-supplement-9.xls-MCF7-T47D-SK-453_Up_MCF7-T47D_x-Supplementary_Table_2_ER-positive_FOXA1_signature_Genes_increased_only_in_MCF7_and_T47D_cells_with_knockdown_of_FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
HELA	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.925265
TRIM28	ENCODE Transcription Factor Targets	1.0	null
abnormal lung morphology	IMPC Knockout Mouse Phenotypes	1.0	null
MCC	Hub Proteins Protein-Protein Interactions	1.0	null
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40811
amygdaloid complex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24256
ubiquitin protein ligase binding	GO Molecular Function Annotations 2023	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
AB-30-CR11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.358377
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10829
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5A-27292631-CHIP-SEQ-BREAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K75177817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04435
negative regulation of nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-PWO3-1026-SM-2I5F2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913481
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.875214
Vegetation	DisGeNET Gene-Disease Associations	1.0	null
Sarcoma_SARC_TCGA-DX-A3M2-01A-21R-A22K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Colonic epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.611
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.25385
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875811
BRD-K42016545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61183
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Uterine cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.825
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58952
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ANXA2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE175787_8_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3670	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.229888
TP53	Pathway Commons Protein-Protein Interactions	1.0	null
anterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.04314
A549_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139695
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carapace	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.001
RQC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.52
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.856832
BRD-K54042694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0323
Bipolar disorder	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.722185
CRCGN015_HEPG2_48H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.66282
JMURTK2	DepMap CRISPR Gene Dependency	1.0	3.73435
JD-44-KF86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229665
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06772291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76192
cellular response to dna damage stimulus	GO Biological Process Annotations 2015	1.0	null
ARHGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
AA-88-PJ86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20372
BRD-K25822126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6059
Finger	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.007
ATP-binding cassette (ABC) transporter complex, transmembrane substrate-binding subunit-containing	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.735
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98342
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2023	1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.583843
point	GeneRIF Biological Term Annotations	1.0	null
ARFGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19417
TORC2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.274
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.37011
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intellectual disability	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.235964
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMD1-0011-R2B-SM-4AT5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850052
FNDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2395
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01965
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.9771
BRD-A67254212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08562
CEBPB_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29778
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3948
RAB1A	MSigDB Cancer Gene Co-expression Modules	1.0	null
Ovarian tumor domain proteases	Reactome Pathways 2024	1.0	null
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376098
PMC5358377-pnas.1615015114.sd02.xlsx-Sheet1-Genes_with_VDR_elements_only_control_VDR	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.48587
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Targets 2022	1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
PMC2853371__F9	PFOCR Pathway Figure Associations 2023	1.0	null
22RV1	DepMap CRISPR Gene Dependency	1.0	2.92348
PMC11292542-main.nxml-Table_2-DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
HCT15	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.849785
ELF5	ChEA Transcription Factor Targets	1.0	null
GTEX-U412-0426-SM-3DB9O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03826
BACH1	ENCODE Transcription Factor Targets	1.0	null
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26069
uterus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.227707
BRD-K56942203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12332
BIRC2	Pathway Commons Protein-Protein Interactions	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47135
CE-04-PX35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241536
4T1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
NFIC_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2788
CRCGN015_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.49042
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281183
MALME3M	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44213
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.847025
COGAR359	DepMap CRISPR Gene Dependency	1.0	2.31265
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.863815
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844684
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
MCF7_Busulfan_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124153
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356373
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56811
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.865644
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.444085
Glutamate synthase complex (NADPH)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.74
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5185-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IA-76-ZU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.450143
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924979
Oral cavity cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.418
PMC11618734-ac4c05127_si_004.xlsx-OPTI-PISA_automated_MTX_900ng-Unnamed_2_ZNF568	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4944136-srep28995-s2.xls-OTX2-gene_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
stimulation	GeneRIF Biological Term Annotations	1.0	null
H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.64392
MYC_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nephritis	DisGeNET Gene-Disease Associations	1.0	null
ACC3	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.08738
GTEX-X8HC-0126-SM-4E3JW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.983109
trovafloxacin_homo sapiens_gpl96_gse9166	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846444
ZR751	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.582063
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2634
GSE120595_5_v_1_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-5429-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Aorta	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.01762
Ovarian tumour, otubain	InterPro Predicted Protein Domain Annotations	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87781745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20542
YTHDF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69971
PAX5_OE_GDS4978_547_human_L428	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.658
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.85012
Carbon phosphorus lyase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.071
Umbilical cord blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32506050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40657
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040649
NCI-H647	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KA-51-CQ55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.584241
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.691
primary auditory cortex (core)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02575
Lung adenocarcinoma_LUAD_TCGA-55-7815-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K36me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71553
Renal cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.911
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.73492
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.65871
BRD-K47217000	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29069
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3770-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A6S6-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPMI-8226 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.765
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.2412
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.93821
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.521584
Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1538
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.251
side	GeneRIF Biological Term Annotations	1.0	null
CAL-33	GDSC Cell Line Gene Expression Profiles	1.0	1.87461
LYRM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35379
PMC12188705-msphere.00110-25-s0007.pdf-77-ZNF500_ZNF500	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13248
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	1.0	0.926639
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Musculoskeletal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.14005
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE124471,GSE124488_1_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cysteine-type peptidase activity	GO Molecular Function Annotations 2015	1.0	null
protein deubiquitination	GO Biological Process Annotations 2015	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mesoderm	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VCAP	CCLE Cell Line Gene Expression Profiles	1.0	2.77839
GP2D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33445
H3K4me3_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10944835-41467_2024_46639_MOESM4_ESM.xlsx-SD17-Supplementary_Data_17_Differentially_expressed_genes_according_to_homozygous_genotype_at_the_TWIST1_locus_TWIST1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HH-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K49733350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30996
RDES	CCLE Cell Line Gene Expression Profiles	1.0	1.39719
BICR22	DepMap CRISPR Gene Dependency	1.0	2.68985
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239466
FOXA1_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19333
GTEX-NPJ8-0011-R1a-SM-33HCB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.602
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52768
IKBKE	Hub Proteins Protein-Protein Interactions	1.0	null
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.873146
vascular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
THAP1	ENCODE Transcription Factor Targets	1.0	null
Skin - Not Sun Exposed (Suprapubic)	GTEx Tissue Gene Expression Profiles 2023	1.0	2.84141
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA2-19941826-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82455
BRD-K31852848	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00146
RT-4 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.853
CRCGN011_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0986
different	GeneRIF Biological Term Annotations	1.0	null
GSE201239_0_v_7_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NANOG	ChEA Transcription Factor Targets	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
WDR1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NFK9-0326-SM-3MJGV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.929318
GSE161055,GSE161056_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MEL-2	GDSC Cell Line Gene Expression Profiles	-1.0	-3.28668
H3K27ac_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K40112492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91537
POU2F1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
TET1	ChEA Transcription Factor Targets	1.0	null
SIN3A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.910888
ECT2	Pathway Commons Protein-Protein Interactions	1.0	null
TP53	ChEA Transcription Factor Targets	1.0	null
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12131
chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.393549
NCI-H460	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.941284
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.62788
Acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
reveal	GeneRIF Biological Term Annotations	1.0	null
polyubiquitin	GeneRIF Biological Term Annotations	1.0	null
superior rostral gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15717
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
prostate	GTEx Tissue Gene Expression Profiles	1.0	0.905029
CAKI-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844684
BRD-K27645251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3824
Lung squamous cell carcinoma_LUSC_TCGA-77-8009-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.013
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H-1299	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.971
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.982714
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88938
Magnetosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.531
MOGS	Pathway Commons Protein-Protein Interactions	1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.2769
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.390799
hydrochlorothiazide-1906	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
chain	GeneRIF Biological Term Annotations	1.0	null
BRD-K56836463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21208
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.36911
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.65824
MALME3M	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52256
Uveal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05643
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36613
Brain cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.130416
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S05_LF_C2_3h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
CX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845072
MCF7_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113416
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5888-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
preweaning lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
GABPA_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT-474	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ED-32-VE54_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256808
PMC9225015-elife-72879-supp5.tsv--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04418
BRD-K21036759	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70206
NCIH838	CCLE Cell Line Gene CNV Profiles	1.0	1.3965
TXN	Pathway Commons Protein-Protein Interactions	1.0	null
ECC12	CCLE Cell Line Gene CNV Profiles	-1.0	-2.40541
FOSL2	ENCODE Transcription Factor Targets	1.0	null
NCIH2286	DepMap CRISPR Gene Dependency	1.0	2.86723
Clear cell renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.372
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.616965
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5117-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K85234739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59653
SUM 149PT	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.44965
NEUROD2-26341353-CORTEX-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
REST_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K39267096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35302
RIC8B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11898
strychnine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21187
biological_process	GO Biological Process Annotations 2015	1.0	null
hippocampus (hippocampal formation)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34959
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tumor Cell Invasion	DisGeNET Gene-Phenotype Associations	1.0	null
GSE193282_2_v_0_cd44_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865844
BRD-K14795621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04612
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
PMC11769652-EHF2-12-250-s001.xlsx-Sheet1-ZEB1_ZEB1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE80537_0_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K82681356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09153
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
BRD-K84685162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10923
PMC5727433-41467_2017_2029_MOESM3_ESM.xls-Sheet1-Supplementary_Data_1_DUB_shRNA_list_used_in_this_study_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K49010888_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYC-18358816-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
interacted	GeneRIF Biological Term Annotations	1.0	null
CB-46-FO63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21429
Chlorosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.844
PMC5489807__F3	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K69678391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27555
POU5F1-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
outer CP in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.921486
BRD-K14599588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21882
GSE158834_0_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE64513_0_v_1_foxd3_human	RummaGEO Gene Perturbation Signatures	1.0	null
culture medium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.204728
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
Apicoplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.584
CRCGN015_MCF10A_48H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63771
GSE135514_2_v_6_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K28216304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17235
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RSU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1885
Brain Lower Grade Glioma_LGG_TCGA-DU-A7T6-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
myeloblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.3356
GM1600	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.37044
hsa-miR-3180	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K88357881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2504
PMC11645450-MCO2-5-e70036.nxml-TABLE_1-DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923116
GSE172295_3_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
monoubiquitination	GeneRIF Biological Term Annotations	1.0	null
PMC9574515-mmc2.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
OTUD6B	Pathway Commons Protein-Protein Interactions	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12169
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRISC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.704
P63-26484246-CHIP-SEQ-KERATINOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
regulation of chromosome organization	GO Biological Process Annotations 2015	1.0	null
RPL18	Pathway Commons Protein-Protein Interactions	1.0	null
BCL3	ENCODE Transcription Factor Targets	1.0	null
GSE140607_3_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197098
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cysteine synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.566
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K33236055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2001
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5935
BRD-K45394633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95861
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE138019_3_v_2_nudt12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU72-0926-SM-2TF6B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.911339
SUM1315MO2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.41782
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8384902-mmc5.xlsx-H2107_PROX1_ChIP-Symbol_PROX1	Rummagene Transcription Factor Associations 2026	1.0	null
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337611
SMC4-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102757_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.37189
PMC9225015-elife-72879-supp1.xlsx-DUB_CRISPR_library-Unnamed_3_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
organism form	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
PMC9010637-mmc6.xlsx-5D-Figure_5D_Gene_Expression_Zhou_et_al_Application_of_SP3-Rox_to_identify_redox_changes_during_T_cell_maturation_SP3	Rummagene Transcription Factor Associations 2026	1.0	null
SKMEL2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.58508
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00226
GSE228413_0_v_3_mavs_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K51448234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17904
Ascidian	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.804
Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.187
Chloroplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.819
head and face region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1135
EGR1	ENCODE Transcription Factor Targets	1.0	null
TC32	DepMap CRISPR Gene Dependency	1.0	2.61004
BRD-K87530935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11144
TGW	GDSC Cell Line Gene Expression Profiles	1.0	2.09682
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.047536
Sarcoma_SARC_TCGA-IW-A3M5-01A-22R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995072
Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
Polytene chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.831
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.840273
dorsal raphe nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.887114
GTEX-QLQW-1226-SM-2S1Q9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.840724
GABPA_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inhibiting	GeneRIF Biological Term Annotations	1.0	null
extracellular vesicular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PMC3944256-cddis201440x1.xls-Primary_Screen_Results-Supplementary_Table_1_Synthetic-Lethal_siRNA_DUB_Screen_for_Mcl1_antagonists_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.018
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.394524
GTEX-QV31-0126-SM-447BP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931243
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08157
SC-8396 (CCND1)	NURSA Protein Complexes	1.0	null
TET1-21451524-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE48812_11_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neoplasm Metastasis	DisGeNET Gene-Phenotype Associations	1.0	null
PPP4R2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00645222
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PFKL	Pathway Commons Protein-Protein Interactions	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.866826
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.866
IGR39	DepMap CRISPR Gene Dependency	1.0	3.12978
BRD-K72807299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1551
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13717
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	2.44963
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UPK5-2026-SM-4JBIM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04996
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K64860662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15844
deptropine-3144	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BL1460 (MAD2L1)	NURSA Protein Complexes	1.0	null
AC-50-FR41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.35848
CREM-20920259-GC1-SPG-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
DE-28-BW67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205099
NPC	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.935
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70848
BRD-K04883778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03075
GSE213632_1_v_5_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K90686617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.027
SNU-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.61519
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051153
TAF7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5489807__F3	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06029
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.892935
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4514	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
K562_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165516
eralpha	GeneRIF Biological Term Annotations	1.0	null
Aa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
regulation of protein modification by small protein conjugation or removal	GO Biological Process Annotations 2015	1.0	null
BL1691 (MAD1L1)	NURSA Protein Complexes	1.0	null
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1159
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.703
gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162445
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.92474
BRD-K79995507	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89111
NPM1	Hub Proteins Protein-Protein Interactions	1.0	null
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06918
PMC12693071-NIHMS2120882-supplement-8.xlsx-Sheet1-scWGS_analysis_of_the_M486_AR_model_AR-specific_or_-enriched_CNV_genes_involved_in_apoptosis_immune_regulation_and_or_known_ICI_resistance_pathways_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NHLH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00596658
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382918
CD200R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00648902
IQGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K28472865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31976
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9936
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06342
VCP-NSFL1C complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.214
SLC9A3R1	Pathway Commons Protein-Protein Interactions	1.0	null
PHA granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.892
BRD-K72488042	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24223
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26127
GSE165704_0_v_1_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
p53	GeneRIF Biological Term Annotations	1.0	null
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
invasion	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K38557728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8245
GSE158834_10_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOS	JASPAR Predicted Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3383-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.518255
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.246755
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
gl6	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.94
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00649
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JU-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLXNA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67037
OTUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63499
lethality throughout fetal growth and development, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
embryoday10.5	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.986405
GTEX-PWCY-2226-SM-2S1OP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862789
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.63371
extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.46905
HT-1080 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.119
BRD-K72253829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79166
disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.045023
MEL285	DepMap CRISPR Gene Dependency	1.0	3.21925
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.95889
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.03824
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.430745
CTCF_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
negative regulation of DNA repair	GO Biological Process Annotations 2025	1.0	null
Mental Disorders	CTD Gene-Disease Associations	1.0	1.10459
negative regulation of protein modification process	GO Biological Process Annotations 2015	1.0	null
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.344
BRD-K56161792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73658
GSE240896,GSE240899_2_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
internal male genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
BRD-K84241565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12575
ZNF263	ENCODE Transcription Factor Targets	1.0	null
BRD-K92524632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25627
TBX2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32385
Rovs	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.712
A172	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.930373
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
AA-30-BE85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238377
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.45742
GSE231648_0_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
prdm1_00000000_e9dot5_placenta_lof_mouse_gpl6887_gse39584	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-1.05277
SW-480 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.149
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.979
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.48204
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_6951_KO_Rbm20_SRP328560	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.08933
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K88746179	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19529
CRCGN015_MCF10A.TP53.M_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25865
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
degradation	GeneRIF Biological Term Annotations	1.0	null
DHX9	Pathway Commons Protein-Protein Interactions	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-1678-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SYO1	DepMap CRISPR Gene Dependency	1.0	2.08897
daudi	HPA Cell Line Gene Expression Profiles	-1.0	-0.985746
MCF7_JNJ-26854165_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150483
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUO-01A-12R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulating	GeneRIF Biological Term Annotations	1.0	null
PKM	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.405193
BRD-K60948317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81703
MCF7_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158917
GSE163240_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Saccule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
BRD-K70412800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05027
Endopeptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.596
GTEX-U4B1-0726-SM-4DXUA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833609
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE102505_4_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3B-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
preweaning lethality, complete penetrance	IMPC Knockout Mouse Phenotypes	1.0	null
imipramine-1849	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HY-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ELK1::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8021
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.109
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.597762
EP300_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K26237438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32155
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CF-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKMEL28	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.87893
iga glomerulonephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.483985
CRCGN012_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44761
KMCH1	DepMap CRISPR Gene Dependency	1.0	2.31561
Colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
cortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.885633
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.96373
Kidney Chromophobe_KICH_TCGA-KL-8324-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.604
BL70	DepMap CRISPR Gene Dependency	1.0	2.58431
Fibrosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.078
fallopiantube_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.843024
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18946
AD-86-OB87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263727
peptidase activity, acting on l-amino acid peptides	GO Molecular Function Annotations 2015	1.0	null
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.91222
GSE180641_0_v_1_zfp503_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF510	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2174
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944547
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
Aerial root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.692
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Multiple Sclerosis	DisGeNET Gene-Disease Associations	1.0	null
outer CP in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01047
entry	GeneRIF Biological Term Annotations	1.0	null
MM1-S cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.691
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.91549
CHD1	ENCODE Transcription Factor Targets	1.0	null
FKBP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59126
SMDT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32073
ARHGEF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06562
regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
KDM5B_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV6-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63757821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87997
GSE197948_2_v_0_atp7b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Forestomach	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.477
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUN_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
P63_DEPLETION_GDS2534_63_human_ME180 cervical carcinoma cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_6993_KO_Mrpp3_SRP076709	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.25291
hippocampus (hippocampal formation)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.840129
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.325
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69201
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.766
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07166
PCK2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K66030669	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47669
SP1	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-95-8494-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.42037
BRD-K84815485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31711
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45609222	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09693
GSE139239_1_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NUMA1	Pathway Commons Protein-Protein Interactions	1.0	null
EBNA2-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Fibroblastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.077
BRD-K61517058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26389
ZNF75D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07563
BRD-K34169251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14163
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06094529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38431
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9908924-41467_2023_36246_MOESM4_ESM.xlsx-Supplementary_data_2-DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
JAK1_activemutant_61_GSE18239	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.59054
ARIH2OS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00611938
ADA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.407
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E4-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF128	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931032
CHAGOK1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.83752
uterine endometrial cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.615377
GTEX-RU72-2926-SM-2TF66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0026
HCC1187	CCLE Cell Line Gene Expression Profiles	1.0	1.75884
COPG1	Pathway Commons Protein-Protein Interactions	1.0	null
tail of caudate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.965599
KDM2B-26808549-CHIP-SEQ-REH-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spikelet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.22
GTEX-SUCS-1426-SM-4DM5W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02713
regulation of chromatin modification	GO Biological Process Annotations 2015	1.0	null
BRD-K77817104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35961
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCUB-M	GDSC Cell Line Gene Expression Profiles	1.0	1.59718
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DMS454	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46526
hsa-let-7b-5p	MiRTarBase microRNA Targets	1.0	null
WF-96-ME07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.464747
CC-15-MK46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216062
UMUC1	CCLE Cell Line Gene Expression Profiles	1.0	1.6435
CRCGN012_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.77588
PMC4963401-fgene-07-00133.nxml--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.62152
RAN	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7II-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XE-01A-12R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.60684
MCF7_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014165
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42775
16081686-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
NMRAL1	Pathway Commons Protein-Protein Interactions	1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.342
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56357490	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43556
PMC4149371-pone.0105180.s010.xls-NANOG-GENE_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84686
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15952
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AARS	Pathway Commons Protein-Protein Interactions	1.0	null
RTCB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10767
GC-04-UF36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.978526
ZFX-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HSPE1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04501
Cytochrome o ubiquinol oxidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.994
RAC1	MSigDB Cancer Gene Co-expression Modules	1.0	null
SPI1-22096565-GC-B-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RAB1A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7506548__F2	PFOCR Pathway Figure Associations 2024	1.0	null
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MYC-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
deubiquitination	GeneRIF Biological Term Annotations	1.0	null
PFN1	Pathway Commons Protein-Protein Interactions	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.48736
MEF cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.218
TBX2-30127528-BE2C-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
structure	GeneRIF Biological Term Annotations	1.0	null
TRAF1	Pathway Commons Protein-Protein Interactions	1.0	null
protein K48-linked deubiquitination	GO Biological Process Annotations 2025	1.0	null
CTBP2	ENCODE Transcription Factor Targets	1.0	null
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.714708
COL6A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05351
SP4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4763-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067589
Gut	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.20988
Ebolavirus(ZEBOV)_6hr_Macrophage_22028943_GSE31747	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.70887
DDX24	Pathway Commons Protein-Protein Interactions	1.0	null
fluoxetine_mus musculus_gpl1261_gse35761	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DAUDI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ENO1	Pathway Commons Protein-Protein Interactions	1.0	null
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.250226
cellular nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
chromosomal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.205916
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4419a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-S7SE-0126-SM-2XCD5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83276
GSE234637_1_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE220520_5_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S7SF-1626-SM-3K2AY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01647
corl279	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.513
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.007
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4U1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12041165-401_2025_2886_MOESM1_ESM.xlsx-Meta_CAA_vs_AD-Genes_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
VCaP	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.97152
PMC6345883-41598_2018_37397_MOESM10_ESM.xlsx-AR_D0_VS_D14__TRANS-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169152_3_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Metabolism of proteins	Reactome Pathways 2024	1.0	null
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-23c	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
PRC1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.401
A549_BMS-911543_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150627
PMC7244323-elife-55325-supp3.xlsx-Noordermeer_TP53-KO-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21928
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.07588
negative regulation of double-strand break repair	GO Biological Process Annotations 2023	1.0	null
MZ7-mel	GDSC Cell Line Gene Expression Profiles	-1.0	-1.4994
VPS45	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_4_KO_Pabpn1l_SRP226170	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.55368
VD-88-MW70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320679
stimulate	GeneRIF Biological Term Annotations	1.0	null
ubiquitin binding	GO Molecular Function Annotations 2025	1.0	null
DA-49-ZD74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392578
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3817
PMC12481283-bmb-58-9-371.nxml-Table_1-DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16357_OE_Ant1_SRP217849	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.54109
HADHA	Pathway Commons Protein-Protein Interactions	1.0	null
PMC3669416-pone.0064838.s001.xls-mHTT-PGR_PGR	Rummagene Transcription Factor Associations 2026	1.0	null
Adrenocortical carcinoma_ACC_TCGA-OR-A5JE-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A388	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.0931
Perturb_5360_KO_Tcf12_SRP392331	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.92048
A673_BONE	CCLE Cell Line Proteomics	1.0	2.64991
GSE151090_5_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
YY1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11976845-pr4c00864_si_003.xlsx-Data_S2E_HeLa_LF-Unnamed_4_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09899
TMEM151A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60033
ar91	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.478
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.709325
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041444
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.977
ID-00-IC14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233523
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01883
regulation of histone h2a k63-linked ubiquitination	GO Biological Process Annotations 2015	1.0	null
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AE-07-IZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.222267
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NPM1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K74259627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25397
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73665
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SOX2	ChEA Transcription Factor Targets	1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25381
SK-MES-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.684
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC12074931-Table_1.xlsx-Sheet1-NFE2L2_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.75016
H3K27ac_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CBP-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
inferior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4418
NCIH292	CCLE Cell Line Gene Expression Profiles	1.0	1.86727
GSE180800,GSE180801_0_v_5_tex10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
LA-42-ER00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.493753
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.473
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.185469
BRD-K07336866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11715
GSE220520_1_v_2_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9464213-41467_2022_33063_MOESM9_ESM.xlsx-BNC2_peptides-gene_name_BNC2	Rummagene Transcription Factor Associations 2026	1.0	null
CAMA1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.64024
GSE220520_5_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
NANOG-16153702-HESC-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
Te	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.512
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.526
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28855
BRD-K05223209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04095
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K47724892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.90077
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.829182
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.44985
RARA-24833708-LIVER-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.97146
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KCL22	CCLE Cell Line Gene Expression Profiles	-1.0	-1.77825
disopyramide-2408	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.48667
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16393
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE240896,GSE240899_10_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K41717398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52027
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-R55G-0326-SM-48FDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.967584
GSE196699_7_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ebolavirus(EBOV)_3day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.89041
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.720741
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
USP21	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00426
BRD-K09146396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80124
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
XRCC5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K67556876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28974
BRD-K49745710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48525
COLO678	CCLE Cell Line Gene Expression Profiles	1.0	1.88796
Cystocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.901
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K90697693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12541
GSE179002_0_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.076
ZNF585A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29371
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8329168-41418_2021_763_MOESM8_ESM.docx-0-DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
COPA	Pathway Commons Protein-Protein Interactions	1.0	null
TMX1	Pathway Commons Protein-Protein Interactions	1.0	null
PRDX3	Pathway Commons Protein-Protein Interactions	1.0	null
MOSPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98666
MCF7_PCI-34051_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180518
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUN	ENCODE Transcription Factor Targets	1.0	null
SF295	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43916
TET1-21451524-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
YWHAB	Pathway Commons Protein-Protein Interactions	1.0	null
Coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.093
lys48linked	GeneRIF Biological Term Annotations	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12357
BRD-K70876639	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22564
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.66558
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21118
KRT10	Pathway Commons Protein-Protein Interactions	1.0	null
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.930288
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00722
gonad	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
Left atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.275
BRD-K19925255	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25626
LRP10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.116
cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
death-inducing signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.725
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288724
FOS_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10789
RPS7	Pathway Commons Protein-Protein Interactions	1.0	null
musculoskeletal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.061261
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.379123
GTEX-WFON-0226-SM-3GIKR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07146
BRD-K68869896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17927
GSE169205_0_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
RBPJ-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE240027,GSE240030_1_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JK-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEAD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0931
IKZF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571426
GSE247862,GSE247863_4_v_3_eomes_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K23963854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30312
Large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MAX_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
uterine endometrium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.182747
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FOXM1	ENCODE Transcription Factor Targets	1.0	null
regulation of protein k63-linked ubiquitination	GO Biological Process Annotations 2015	1.0	null
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873355
GSE152055_2_v_3_mpc1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
negative regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
connective tissue cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.180652
K562_PD173074_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147672
LMO2-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE146612_1_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1-23942234-MYOBLASTS AND MYOTUBES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_6053_KD_PRMT1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H4K20me1_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052891
CREB1	ChEA Transcription Factor Targets	1.0	null
GSE87299_2_v_3_nr1d1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04393
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GET complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.575
BRD-K30236306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18875
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.480855
BRD-K02959126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03823
MCM6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06343
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25512
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K18307373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10098
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.914208
DCAF7	Pathway Commons Protein-Protein Interactions	1.0	null
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.83965
SIRT6	ENCODE Transcription Factor Targets	1.0	null
UBE2E1	Pathway Commons Protein-Protein Interactions	1.0	null
TUBA1C	Pathway Commons Protein-Protein Interactions	1.0	null
GSE137144_5_v_7_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SMAD9	Hub Proteins Protein-Protein Interactions	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PLZ5-0626-SM-2I5F8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976753
Gill	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.278
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Fusome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.547
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65246
Deubiquitination	Reactome Pathways 2024	1.0	null
GSE199921_1_v_0_romidepsin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
COV362	CCLE Cell Line Gene CNV Profiles	1.0	1.73224
OVCAR8	BioGPS Cell Line Gene Expression Profiles	1.0	1.59312
Aplastic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
DB-73-BC12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231139
PMC7244323-elife-55325-supp3.xlsx-This_paper_TP53-KO-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
MYC_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1437	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36613
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
DDX5	Pathway Commons Protein-Protein Interactions	1.0	null
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RELA_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K83189379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05072
LDHA	Pathway Commons Protein-Protein Interactions	1.0	null
hfff2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.525
Endometrial Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K71452779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32769
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.998629
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.19651
SLAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.836
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
GSE154081_3_v_0_sildenafil_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
DDX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71924
hsa-miR-4433	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.448451
Diffuse large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
nedd8-specific protease activity	GO Molecular Function Annotations 2015	1.0	null
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.7509
GSE210655_1_v_6_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
plant-type cell wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.095
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A5VK-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormal heart position or orientation	MGI Mouse Phenotype Associations 2023	1.0	null
COLGALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15956
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44462
BRD-K38358574	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45376
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.34902
TFAP2C_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K37696710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6857
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SUDHL10	DepMap CRISPR Gene Dependency	1.0	2.42382
AHNAK	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8433-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A680-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DNA damage response	GO Biological Process Annotations 2023	1.0	null
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.863188
BRD-K17060750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00263
U2-OS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.702
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.41446
INO80-type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.107
mediated	GeneRIF Biological Term Annotations	1.0	null
BRD-K19829092	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64365
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.268
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.04
ADORA2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005022
inner CP in granular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0514
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833698
Cervical cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.487
UBE2S	Pathway Commons Protein-Protein Interactions	1.0	null
GFM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96137
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04912
Fetal Death	CTD Gene-Disease Associations	1.0	1.64168
ACTN4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K08353229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10078
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4666-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69152679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56652
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.008
GTEX-X5EB-0526-SM-46MVP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09215
developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.048382
BRD-K36575476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08441
telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE137653_4_v_0_siglecf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
deubiquitinase activity	GO Molecular Function Annotations 2025	1.0	null
hsa-miR-93-3p	MiRTarBase microRNA Targets	1.0	null
Chagas Disease	DisGeNET Gene-Disease Associations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-0944-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.123133
cellular_component	GO Cellular Component Annotations 2015	1.0	null
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
BL2458 (UBE2L3)	NURSA Protein Complexes	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VHL	Pathway Commons Protein-Protein Interactions	1.0	null
therefore	GeneRIF Biological Term Annotations	1.0	null
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
otub1d88a	GeneRIF Biological Term Annotations	1.0	null
Hair root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.502
GSE211177,GSE211178_8_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22099
SMAD2/3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NANOG-16153702-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856895
placenta_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.0096
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2B	ENCODE Transcription Factor Targets	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5068-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EK-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.96206
Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUGC3	CCLE Cell Line Gene Expression Profiles	1.0	1.48226
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.241746
Weight Loss	CTD Gene-Disease Associations	1.0	1.35155
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GP5D	DepMap CRISPR Gene Dependency	1.0	2.79292
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC3669416-pone.0064838.s001.xls-mHTT-AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.30055
PMC12069319-Table1.xlsx-OCAB_p35_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
rh30	HPA Cell Line Gene Expression Profiles	-1.0	-2.00926
GATA2	ChEA Transcription Factor Targets	1.0	null
outer CP in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.952563
ASXL1-24218140-BMDM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K36me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM2B-26808549-CHIP-SEQ-SUP-B15-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.84391
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47896
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957637
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10062
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ADO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26836
primary motor cortex (area M1, area 4)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08188
PMC4728380-ncomms10153-s8.xlsx-MYC_binding_intensity_ALL-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
HGC-27 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.891
GSE137144_4_v_6_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NIH:OVCAR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.830595
HMX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45762
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A194-01A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K89277562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0087
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08711
BRD-K16598630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27821
necrosis	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fluvoxamine-2913	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2A_bone marrow macrophage_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR3C2-34362910-WISTARRAT-HIPPOCAMPUS	ChEA Transcription Factor Targets 2022	1.0	null
PMC12005766-ADVS-12-2413120-s003.xlsx-VENN3-Table_S6_related_to_Figure_S6D_List_of_overlapping_DEGs_screened_in_VENN1_with_DUBs_interacting_with_EZH2_or_MYC_from_the_UbiBrowser_v2_database_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PJA1	Pathway Commons Protein-Protein Interactions	1.0	null
UOK101	CCLE Cell Line Gene CNV Profiles	1.0	1.49759
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15467
AML - Acute myeloid leukemia_Mononuclear Leukocyte_GSE2191	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	0.182302
GTEX-XQ3S-1426-SM-4BOPR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34544
BRD-K33128056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81738
AP3D1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P4QT-0126-SM-2I3FL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02121
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fluoxetine-2453	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HUWE1	Pathway Commons Protein-Protein Interactions	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.75923
forelimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096264
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SZ in subgenual cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.970796
Cardiac microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.717
BRD-A79248021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26988
TPI1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5524348-pone.0181667.s005.xlsx-Inflammation-MINT_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE186647,GSE217287_1_v_3_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleus	GO Cellular Component Annotations 2023	1.0	null
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65709
GTEX-P44H-0326-SM-2XCES	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905434
BRD-K91885806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04457
other	GeneRIF Biological Term Annotations	1.0	null
Nasopharynx	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.268
Formate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.746
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10435664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95159
GTEX-RVPU-0011-R1A-SM-2XCAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970922
SF295	GDSC Cell Line Gene Expression Profiles	-1.0	-2.31682
hsa-miR-4510	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
H3K36me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.245
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65496
outer CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37497
GTEX-XPVG-0326-SM-4B653	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900732
clathrin-coated vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.117
BRD-K52379519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34961
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.656
Eye	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4934
KLHL31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35013
isopeptide	GeneRIF Biological Term Annotations	1.0	null
Mesocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
GNB2L1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-QMR6-1426-SM-32PLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6808
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.1633
ETFA	Pathway Commons Protein-Protein Interactions	1.0	null
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.58932
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-1.18432
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
496100330_PCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.72515
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.55943
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95691
hsa-miR-634	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
ALDOA	Pathway Commons Protein-Protein Interactions	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-4749-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM63	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K23405293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27322
SPI1-20176806-THIOMACROPHAGE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Germinated grain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.82
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6633
BRD-K62085719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18862
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC2998	DepMap CRISPR Gene Dependency	1.0	2.04722
GSE158815_5_v_3_trib1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23724
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
polytene chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.706598
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5193459-pone.0168968.s009.xlsx-Dharmacon_OTP_siRNA_Area-Symbol_OTP	Rummagene Transcription Factor Associations 2026	1.0	null
DIFI	DepMap CRISPR Gene Dependency	1.0	3.0488
FOXP2_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869791
recognition	GeneRIF Biological Term Annotations	1.0	null
Glutathione synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.405
EXO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0054193
negative regulation of nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
tocainide-2931	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57653
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.704215
Brain Lower Grade Glioma_LGG_TCGA-WY-A859-01A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tube foot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.045
Kidney cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.095
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.267791
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57598
FTC238	CCLE Cell Line Gene Expression Profiles	-1.0	-2.0965
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22902
Neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
cerebellar cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861151
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
methylphenidate_mus musculus_gpl11180_gse33619	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67R-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VUSG-1426-SM-3GIJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97471
BRD-K90474764	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08263
Connective tissue cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
BRD-K74727418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8506
IMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20449
DPH5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00483189
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4343
BRD-K98061543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08999
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K79697020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49378
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944504
EBF1	ENCODE Transcription Factor Targets	1.0	null
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.336241
ventrolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05122
Spinal cord	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
NO11	DepMap CRISPR Gene Dependency	1.0	2.8918
suppress	GeneRIF Biological Term Annotations	1.0	null
SMAD4-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_6324_KD_AdipoR1_SRP377446	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.7524
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52555
GSE166315_5_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
OE-78-XD40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.434243
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cellulosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.447
Hypertension	CTD Gene-Disease Associations	1.0	1.29688
BAT3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.167
Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DSP	Pathway Commons Protein-Protein Interactions	1.0	null
Caryopsis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.377
VMCUB1	CCLE Cell Line Gene CNV Profiles	1.0	1.79405
ANXA1	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-FC-A66V-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.462489
Ubiquitin thioesterase OTUB1	InterPro Predicted Protein Domain Annotations	1.0	null
extracellular organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0091
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.86567
TUBA3C	Pathway Commons Protein-Protein Interactions	1.0	null
SNRNP70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07225
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07434
regulation of response to stress	GO Biological Process Annotations 2015	1.0	null
ATP-dependent citrate lyase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.87
NCI-H1793	COSMIC Cell Line Gene Mutation Profiles	1.0	null
COLO 800	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3117
BRD-K57115335	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19099
decreased exploration in new environment	IMPC Knockout Mouse Phenotypes	1.0	null
GSE114690_1_v_3_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.998629
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51411
RCC10RGB	DepMap CRISPR Gene Dependency	1.0	2.18248
BRD-K51181201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.63665
A549_Sirtinol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013784
HEL	DepMap CRISPR Gene Dependency	1.0	2.27991
impaired	GeneRIF Biological Term Annotations	1.0	null
bacterial	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K64531863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30449
umbilicalcord	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.61723
nephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.160948
Derlin-1 retrotranslocation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.395
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PRKAG1	MSigDB Cancer Gene Co-expression Modules	1.0	null
QA-07-KC40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.677784
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OZ-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_PHA-680632_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141535
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE161295_4_v_1_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211177,GSE211178_0_v_11_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DNA damage response	GO Biological Process Annotations 2025	1.0	null
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.963596
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.0344
ELF5-23300383-T47D-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.975614
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HU-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
DTD1	Pathway Commons Protein-Protein Interactions	1.0	null
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.891795
18842155-Table2	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
remoxipride-3124	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Familial combined hyperlipidaemia_Blood monocyte_GSE11393	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.73416
KDM6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10364
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	1.0	null
crystal	GeneRIF Biological Term Annotations	1.0	null
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.656
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.538
JURKAT	CCLE Cell Line Gene Expression Profiles	-1.0	-1.50889
MYC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21495
MYCN-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
UO31	BioGPS Cell Line Gene Expression Profiles	1.0	0.92676
Transitional cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.008
connecting stalk	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.880349
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TMMY-0626-SM-33HBD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843677
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.732
Lung adenocarcinoma_LUAD_TCGA-95-A4VP-01A-21R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.828589
LDLR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18474
AB-12-IS33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.300356
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5EO-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.783
GTEX-X4EO-2926-SM-4E3JH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867221
KTC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.99
HDAC2_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
protein K48-linked deubiquitination	GO Biological Process Annotations 2023	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13351
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.68093
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A50J-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K05474024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02727
KDM2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41987
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4123
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.6684
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHGDH	Pathway Commons Protein-Protein Interactions	1.0	null
Nymph	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.925
GTEX-QDT8-2926-SM-32PKC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50543
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1438	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66587
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040312
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36488
UM-UC-14 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.6
Urinary bladder transitional cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.011
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.80215
umbilical artery	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
regulation of nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K14359826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59852
BRD-K02548315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11857
Peptidase C65, otubain	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K30533903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38901
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.43064
CRCGN015_MCF10A.WT.HP_24H:A23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.10304
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04117
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221217
CD14+_Monocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.96535
AR-25329375-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-1226	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
YD-49-HM53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.931735
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
G124	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844684
GSE240896,GSE240899_2_v_4_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4729	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TTC549	DepMap CRISPR Gene Dependency	1.0	2.64663
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CE-20-VA70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.378783
BRD-K36237864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15352
ZNF281	ChEA Transcription Factor Targets	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PM-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.34806
Lung adenocarcinoma_LUAD_TCGA-38-4630-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BHY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.44343
WDR5-24793694-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.616284
YD38	CCLE Cell Line Gene CNV Profiles	1.0	1.39116
PMC3637405__F2	PFOCR Pathway Figure Associations 2024	1.0	null
TBL1-22424771-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cysteine-type peptidase activity	GO Molecular Function Annotations 2023	1.0	null
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CREM	ChEA Transcription Factor Targets	1.0	null
H4K20me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE188570,GSE188571_5_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.7684
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03949
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.12
BRD-A78982410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14842
BRD-A00327403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.52249
ubiquitin-like protein ligase binding	GO Molecular Function Annotations 2015	1.0	null
negative regulation of protein modification by small protein conjugation or removal	GO Biological Process Annotations 2015	1.0	null
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214765
RPMI7951	DepMap CRISPR Gene Dependency	1.0	2.92947
BRD-K98578493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35125
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU840	DepMap CRISPR Gene Dependency	1.0	2.78631
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.389
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Supplementary_Table_9A_The_effects_of_whole_blood_transcripts_on_COVID-19_severity_with_suggestive_Mendelian_randomization_evidence_P_0_05_using_Genomicc_data_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH1184	CCLE Cell Line Gene CNV Profiles	1.0	1.43077
MCF7_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163751
SK-MEL-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.935851
KYSE-180	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.78326
CACNG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00653406
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.913
all	GWASdb SNP-Phenotype Associations	1.0	0.034546
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11143964-jciinsight-9-161356-s009.pdf-15-ZNF841_ZNF841	Rummagene Transcription Factor Associations 2026	1.0	null
Necrosis	CTD Gene-Disease Associations	1.0	1.48838
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.948
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
response to stimulus	GO Biological Process Annotations 2015	1.0	null
EOL1	DepMap CRISPR Gene Dependency	1.0	4.06608
BRD-K51054674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42717
VCAP	CCLE Cell Line Gene CNV Profiles	1.0	2.66211
YY1	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K82314391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25545
Microsporidian	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.55
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S01_LF_C1_3h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39546571	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3652
Succinate dehydrogenase complex (ubiquinone)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.299
GTEX-S4Z8-1826-SM-3K2BH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980634
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.969412
GTEX-T5JW-0126-SM-4DM6K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922166
MCF7_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142414
Liver hepatocellular carcinoma_LIHC_TCGA-DD-AA3A-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
20630075-AF-2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K81821040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28868
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC3728595-srep02327-s1.pdf-1622-ZBTB7B_ZBTB7B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K54686062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37779
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76943
BRD-K53343197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07699
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Root hair	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.715
RBPJ	ChEA Transcription Factor Targets	1.0	null
AC-50-FR41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259707
CRCGN014_HEPG2_3H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19917
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.035
specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.049933
oe47	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.739
CML - Chronic myeloid leukemia_Haematopoietic stem cell_GSE11889	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.98491
ubiquitin-like protein ligase binding	GO Molecular Function Annotations 2025	1.0	null
Methyl coenzyme M reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.081
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RIDDLE syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.765
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLVL	DepMap CRISPR Gene Dependency	1.0	2.33291
A549_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181451
ELF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13451
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.35868
GSE240386,GSE242143_8_v_6_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE145323,GSE145324_1_v_4_rfx3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26349
BRD-K04695993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32697
GSE211226_1_v_2_sirpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rg94a	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.465
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33399
liver	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.00632
SIN3A_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
metixene-2451	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7821388-DataSheet_3.xlsx-MYBL2_DDR_ChIPseq_Analysis-Gene_MYBL2	Rummagene Transcription Factor Associations 2026	1.0	null
PDIA3	Pathway Commons Protein-Protein Interactions	1.0	null
16651414-Supp2	GeneSigDB Published Gene Signatures	1.0	null
CREBRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76988
PMC9846571-Table_1.xls-1-NFE2L2_NFE2L2	Rummagene Transcription Factor Associations 2026	1.0	null
striatum_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.826041
6611_PPAT_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.785594
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230944
NEDD8	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36128
Inflorescence stalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.778
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.177724
MDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23535
BRCA1-A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.868
BRD-K48406740	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26953
AF-00-QK19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20995
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.6194
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.608
SMAD3	Pathway Commons Protein-Protein Interactions	1.0	null
JHH-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.904018
D502MG	DepMap CRISPR Gene Dependency	1.0	2.27141
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16217
GSE164463_4_v_1_pax6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.509
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.60571
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
extracellular vesicle	GO Cellular Component Annotations 2015	1.0	null
TUBB2A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03399
PMC4905335__F1	PFOCR Pathway Figure Associations 2023	1.0	null
ELK4_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMAD4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K79me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_Danusertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148689
CUX1	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8305-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PKN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38989
NB10	DepMap CRISPR Gene Dependency	1.0	2.473
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13093
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EFM19_BREAST	CCLE Cell Line Proteomics	1.0	3.89662
USF1	ENCODE Transcription Factor Targets	1.0	null
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.644679
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14023
Ovariole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.896
BRD-A64774838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12165
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
KA-37-GD83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322185
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.686
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.47012
Sarcoma_SARC_TCGA-JV-A75J-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BIRC3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-A67521865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49796
BRD-K68257831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17365
LO68	DepMap CRISPR Gene Dependency	1.0	2.42243
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-46-6025-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132432
Urinary bladder cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.58569
cytoplasm	GO Cellular Component Annotations 2015	1.0	null
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944975
AR-20517297-VCAP-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.448146
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K88478877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86068
Vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.102
cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BZW1	Pathway Commons Protein-Protein Interactions	1.0	null
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
IDH2	Pathway Commons Protein-Protein Interactions	1.0	null
GP5D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24558
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.916679
CHRNA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496138
JHH5	CCLE Cell Line Gene CNV Profiles	1.0	1.52439
GTEX-R55D-1126-SM-48FEB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90835
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23399
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
ENTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66734
MutLalpha complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.784
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CB-02-XL81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.273338
SUM 1315M02	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15467
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.855483
PNMA8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84107
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0691
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21096
JUP	Pathway Commons Protein-Protein Interactions	1.0	null
HSPB1	Pathway Commons Protein-Protein Interactions	1.0	null
E2F4	ENCODE Transcription Factor Targets	1.0	null
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09377
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HUPT4	DepMap CRISPR Gene Dependency	1.0	2.6965
non-small cell lung cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.72
ACTN1	Pathway Commons Protein-Protein Interactions	1.0	null
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K58932103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30365
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE139239_3_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.842284
RFX5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE123958,GSE123959_0_v_1_mta1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SAGA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.383
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Ubiquitin activating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.444
WDR61	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69H-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of histone H2A K63-linked ubiquitination	GO Biological Process Annotations 2023	1.0	null
HYOU1	Pathway Commons Protein-Protein Interactions	1.0	null
nucleus coeruleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.890044
GTEX-QMRM-0526-SM-2I5GA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890353
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RUVBL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K04426746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0339
Edinger-Westphal nucleus (accessory oculomotor nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.9493
PMC9264807__F2	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K87821938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89697
GATA3-21867929-CD8-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K45978015	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05619
PMC7771094-12920_2020_832_MOESM5_ESM.txt--ATF2_ATF2	Rummagene Transcription Factor Associations 2026	1.0	null
FLNA	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9378837-Table_3.xlsx-ESR1_upstream_regulators-2000-2021_QIAGEN_All_rights_reserved_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
nurse cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.4034
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CREB1-23762244-HIPPOCAMPUS-RAT	ChEA Transcription Factor Binding Site Profiles	1.0	null
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MELHO	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32594
subcuneiform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.984278
hsa-miR-4512	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
NFKB2	Pathway Commons Protein-Protein Interactions	1.0	null
B-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.0
SNU-668	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.08043
endometrial cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.456055
GSE245270_1_v_0_isoproterenol_human	RummaGEO Drug Perturbation Signatures	1.0	null
SNU-407	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XQ3S-1126-SM-4BOPK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18807
BRD-K28983467	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14076
TRAF2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98190019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91836
MAT1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16492
Uterine Carcinosarcoma_UCS_TCGA-NA-A5I1-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K09767767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34373
GTEX-OIZH-2026-SM-3NB1M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935224
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.829638
acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.671
GSE175787_13_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
SW962	GDSC Cell Line Gene Expression Profiles	1.0	1.45869
GSE234637_1_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EBC1	CCLE Cell Line Gene CNV Profiles	1.0	1.42058
GTEX-XPVG-2226-SM-4B65U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846114
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3064265-NIHMS252278-supplement-3.xls-A_Interactions-Supplementary_Table_2_DUB_data_No_Control_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
HMGN3	ENCODE Transcription Factor Targets	1.0	null
MAX_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70A-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BNC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.424
Spore wall	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.601
LOX-1_OE_GDS4262_435_human_HAECT - aortic endothelial cell line - 24 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE119978,GSE180930_2_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K00877314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02157
BRD-K34456337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60129
dorsolateral prefrontal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.69341
pentamidine-2473	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RAP2C	Pathway Commons Protein-Protein Interactions	1.0	null
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
COLO 849	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12015
T-cell acute lymphoblastic leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
GSE137818_2_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
YY1_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01192
BRD-K40061713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03091
BRD-K57262525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73174
Nurse cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.007
Pancreatic ductal carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.939
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-TMMY-1126-SM-4DXSX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1202
NR2C2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.352227
CRCGN014_HEPG2_24H:I24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56431
Renal cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.05
NME1	Pathway Commons Protein-Protein Interactions	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
KAT2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and neck cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.307
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.24675
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.461659
GSE221539_1_v_3_lrrc10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10653_ZNF80_ENST00000482457.2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574331
EBNA2-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
outer CP in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.932722
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71817857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14544
BRD-K35963610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20246
regulation of cellular response to stress	GO Biological Process Annotations 2015	1.0	null
GSE198165,GSE198166_5_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.08934
Arbuscule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.665
frontal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0254
BRD-K42799692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24587
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925104
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterus	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.73861
HCC1419	CCLE Cell Line Gene CNV Profiles	1.0	2.00702
Pancreatic adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.347
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.549728
PDIA4	Pathway Commons Protein-Protein Interactions	1.0	null
PHB	MSigDB Cancer Gene Co-expression Modules	1.0	null
PMC3419980-leu201249x2.xls-RUNX1-ETO_siRE_ChIPSeq_peaks_ge-gene_name_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
monocytes	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886648
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190384,GSE190386_3_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
USF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57435
CRCGN015_MCF10A_48H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.16351
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.789
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BFTC-909	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.9758
lateral parabrachial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26819
BRD-K41504921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43932
NCI-H1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15731
MCC	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6JN-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1419	GDSC Cell Line Gene Expression Profiles	1.0	1.44793
ELF5-23300383-T47D-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5973-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K07589203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26315
CRCGN011_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03412
Multivesicular body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.357
BRD-K45222498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43175
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.62151
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q7-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Midgut epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.589
superior parietal lobule, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.0126
Perturb_3089_KO_Fkbp5_ERP017365	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.52864
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4334-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.68169
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW-620 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.0519
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07872
ARID3A	JASPAR Predicted Transcription Factor Targets	1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.502926
CAL62	CCLE Cell Line Gene CNV Profiles	1.0	1.60495
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPTAN1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QC-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sapling	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
ubiquitin-like protein-specific protease activity	GO Molecular Function Annotations 2015	1.0	null
TRIM54	Pathway Commons Protein-Protein Interactions	1.0	null
GABPA_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE119978,GSE180930_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.59613
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00848
PRKAR2A	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_16308_KO_BUD31_SRP335732	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-19.699
DDX23	Pathway Commons Protein-Protein Interactions	1.0	null
metabolic process	GO Biological Process Annotations 2015	1.0	null
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF126	Pathway Commons Protein-Protein Interactions	1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TE5	CCLE Cell Line Gene Expression Profiles	1.0	1.36975
ubiquitinyl hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.906
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of histone ubiquitination	GO Biological Process Annotations 2015	1.0	null
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.068634
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.922224
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7094_OE_miR128_SRP126105	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.41653
TE5	CCLE Cell Line Gene CNV Profiles	1.0	1.7325
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.47182
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.268
subcallosal cingulate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.860786
GTEX-SNMC-0926-SM-4DM5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30422
GTEX-OHPM-0326-SM-33HCA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965842
extracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01523
BRD-K89459607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25925
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Testis	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.712188
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.1373
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21118
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RM2N-1826-SM-2TF5B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.987773
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein modification by small protein conjugation or removal	GO Biological Process Annotations 2015	1.0	null
BRD-K99681648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19836
Uveal melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
Autosomal dominant cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.245
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Clathrin adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.066
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IA-27-CK10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.429
SKMEL2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7351
H3K9me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K78202004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07087
H3K27ac_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MSH2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K79me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC7165618-IUB-62-140.nxml--DUB_name_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
esr1_21299862_mcf7_lof_human_gpl570_gds4065	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.815952
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.426
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE247862,GSE247863_0_v_5_eomes_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
negative regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
5637	CCLE Cell Line Gene Expression Profiles	1.0	1.3876
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.113
Prostate adenocarcinoma_PRAD_TCGA-G9-6379-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1569	COSMIC Cell Line Gene Mutation Profiles	1.0	null
studies	GeneRIF Biological Term Annotations	1.0	null
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_hexaplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
FE-82-WB22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.16742
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.937132
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.968786
Lung adenocarcinoma_LUAD_TCGA-86-8279-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KRT77	Pathway Commons Protein-Protein Interactions	1.0	null
NarGHI complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.981
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4492
Breast carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.149
PMC10654515-41467_2023_43245_MOESM4_ESM.xlsx-Putative_ERG_binding_proteins-Unnamed_1_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
severe acute respiratory syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.788033
clozapine_mus musculus_gpl339_gds2531	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K70343553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91325
Cob	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.612
GABPA_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-0226-SM-3GIKN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878006
VHL	Hub Proteins Protein-Protein Interactions	1.0	null
ATF3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBR4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K85441584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72462
GTEX-NPJ8-0126-SM-2YUNR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941417
negative regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21040167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16394
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gut	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.097217
USP8	Pathway Commons Protein-Protein Interactions	1.0	null
Megasporocyte nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.594
HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA	ChEA Transcription Factor Targets 2022	1.0	null
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ubiquitin binding	GO Molecular Function Annotations 2023	1.0	null
MCF7_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0158025
CRCGN008_HEPG2_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04365
tonsil_8a1	HPA Tissue Sample Gene Expression Profiles	1.0	0.957494
Prestwick-984-2903	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
regulation of response to stimulus	GO Biological Process Annotations 2015	1.0	null
golgi apparatus	LOCATE Predicted Protein Localization Annotations	1.0	null
Bacteriocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.669
ER membrane insertion complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.084
SubthalamicNucleus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.943172
ras	Phosphosite Textmining Biological Term Annotations	1.0	null
HEC251_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.66258
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gata4_16914500_e9dot5_atrioventricular_canal_lof_mouse_gpl1261_gds3663	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.447148
HS-Sultan cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.824
BRD-K37282009	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41419
RPS14	Pathway Commons Protein-Protein Interactions	1.0	null
IGR1_SKIN	CCLE Cell Line Proteomics	1.0	3.08273
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11354
myocardial infarction	GWASdb SNP-Disease Associations	1.0	1.32349
IM95	DepMap CRISPR Gene Dependency	1.0	2.98423
reporter	GeneRIF Biological Term Annotations	1.0	null
CAL-12T	GDSC Cell Line Gene Expression Profiles	1.0	1.57986
HCC1599	CCLE Cell Line Gene CNV Profiles	-1.0	-2.00801
KRIT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06462
CRCGN008_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4562
BRD-K42191735_buparlisib_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SIN3B-21632747-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K75610411	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49756
KYSE-150	GDSC Cell Line Gene Expression Profiles	-1.0	-1.54692
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SCC-25	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09438
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12676
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3C3-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K50726251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02568
RAD21_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03053
PMC8908266__F1	PFOCR Pathway Figure Associations 2024	1.0	null
IE-36-BO23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211728
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23034
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24496
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
18593951-TableS3	GeneSigDB Published Gene Signatures	1.0	null
deubiquitinase activity	GO Molecular Function Annotations 2023	1.0	null
CDKN1A	Pathway Commons Protein-Protein Interactions	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A58803929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79184
AA-99-HO76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.531512
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.042356
GSE151612_0_v_3_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_11258_KO_Mkp1_SRP169858	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.13431
Methane monooxygenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.159
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11211849-btae257_supplementary_data.pdf-13-MLXIPL_MLXIPL	Rummagene Transcription Factor Associations 2026	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055409
Malignant Tumor Of Colon	DisGeNET Gene-Disease Associations	1.0	null
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
enzyme binding	GO Molecular Function Annotations 2015	1.0	null
hand	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.323509
PMC7506548__F2	PFOCR Pathway Figure Associations 2023	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GD-71-OU80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200516
496100340_TCx_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.69133
DLD-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19763
HDAC6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intestine	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00838
chromosomal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.298455
wherein	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70H-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
P300-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
SIN3A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19987
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.23284
GSE110268_0_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYCN	ChEA Transcription Factor Targets	1.0	null
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.899421
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.59878
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33653
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	1.0	2.98677
Cellular metabolism and vesicular transport regulation	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969927
20436685-ST4-1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13508
GTEX-XUZC-1726-SM-4BRWS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21669
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC3A2	Pathway Commons Protein-Protein Interactions	1.0	null
SOX2-21211035-LN229-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
ABCF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23469
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ACAD9	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
u26684	HPA Cell Line Gene Expression Profiles	-1.0	-1.05103
abnormality of the immune system	GWASdb SNP-Phenotype Associations	1.0	0.089495
BF-94-CQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249616
PMC8542838-fimmu-12-742542.nxml--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.558
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TET1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08446
POU5F1-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K47814830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53019
charged	GeneRIF Biological Term Annotations	1.0	null
BRD-K94845132	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01095
Perturb_18006_KO_Grn_SRP070945	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.84729
Bone cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.593
CBX3	ENCODE Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5EB-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Divalproex Sodium_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129921
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BT474	CCLE Cell Line Gene Expression Profiles	1.0	2.26912
PGGT1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23757
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.558
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.767
OV-7	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.675
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351963
BRD-K45952474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12539
SF539	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4997
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.58256
Ub-specific processing proteases	Reactome Pathways 2024	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04132
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	13.3455
bone marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.245175
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210655_1_v_5_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.57153
Histone acetyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.477
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OCT1-27270436-CHIP-SEQ-PROSTATE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
T-tubule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.08
BRD-K60781525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47517
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
ZFX	ChEA Transcription Factor Targets	1.0	null
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
trans-Golgi network transport vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.3
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A654-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A11130173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84452
Ruminal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.675
PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1	Rummagene Transcription Factor Associations 2026	1.0	null
BRCA1-B complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.502
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1913	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
primary visual cortex (striate cortex, area V1/17)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.909081
OB-20-LP90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.236936
layer I of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.826489
GSE169571_3_v_4_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.91505
GSE146612_2_v_0_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BLZF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590113
BRD-K60389305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34729
BRD-K59893572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47383
GSE190384,GSE190386_6_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BICR16	DepMap CRISPR Gene Dependency	1.0	2.49706
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
TRIM55	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24729
POLR2AphosphoS5_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRMT6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43596
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AI-0426-SM-48U13	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13564
PMC9225015-elife-72879-supp4.tsv--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24558
Penis_Foreskin_Melanocyte_Primary_Cells_skin01	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.80943
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6995-01A-31R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
conjugation	GeneRIF Biological Term Annotations	1.0	null
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65832
MYC	ENCODE Transcription Factor Targets	1.0	null
A549_MC1568_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143234
E2F6	ENCODE Transcription Factor Targets	1.0	null
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.268
Lung adenocarcinoma_LUAD_TCGA-78-7163-01A-12R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DB-54-GQ68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.379909
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74203
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HB-06-WU12_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.497417
AD-86-ES28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251085
UTP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.63881
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Common_KLF5_peaks-Nearest_Ensembl_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of cellular component organization	GO Biological Process Annotations 2015	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.79293
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Glume	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.287
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GABPA_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.37888
GSE149264,GSE149267_9_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FLT4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00663946
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IP6K1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602488
ovarian	Phosphosite Textmining Biological Term Annotations	1.0	null
TGFBR1	PhosphoSitePlus Substrates of Kinases	1.0	null
cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Pancreatic adenocarcinoma_PAAD_TCGA-OE-A75W-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
PLEKHO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21786
GTEX-OXRO-0126-SM-2YUN4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904904
GPI	Pathway Commons Protein-Protein Interactions	1.0	null
DYNC1H1	Pathway Commons Protein-Protein Interactions	1.0	null
ACTR10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44063
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE172295_0_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.3775
HCC1419	CCLE Cell Line Gene Expression Profiles	1.0	2.88869
JUND	ENCODE Transcription Factor Targets	1.0	null
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.97739
PRKDC	Pathway Commons Protein-Protein Interactions	1.0	null
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.07892
Sarcoma_SARC_TCGA-DX-A8BH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_12842_KO_Tet2_SRP338315	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.37625
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81448
GSE144796_3_v_0_linagliptin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
inhibits	GeneRIF Biological Term Annotations	1.0	null
KRT8	Pathway Commons Protein-Protein Interactions	1.0	null
RPS27A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE142210_3_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YWHAE	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A4CL-01A-41R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.016
hsa-miR-4269	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
ESCRT III complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.181
17023574-TableS1	GeneSigDB Published Gene Signatures	1.0	null
ifn	GeneRIF Biological Term Annotations	1.0	null
USF2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Myeloid neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.605
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58943
umbilical cord blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-X5EB-1826-SM-4E3K8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31474
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02766
regulation of protein ubiquitination	GO Biological Process Annotations 2015	1.0	null
OXSR1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36472
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.5574
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE87404,GSE87812_1_v_3_hoxa9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0190271
BRD-K43719900	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2845
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261747
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17866
SMAD9	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_15858_KD_DDX5_SRP267072	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-3.7377
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.742
POLR2A_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 839.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.949664
AP-1 adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.301
GTEX-XOTO-0126-SM-4B66N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14819
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
artery disease	GWASdb SNP-Disease Associations	1.0	0.173571
macromolecule modification	GO Biological Process Annotations 2015	1.0	null
CTAGE15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5919
MYH9	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EJ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
mood disorder	GWASdb SNP-Disease Associations	1.0	0.355861
Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.905065
GATA1-19941826-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.448451
GSE142210_9_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052943
outer CP in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.979863
TFAP2C-20629094-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.82216
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.98189
EP300_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3IB-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73548
TEAD4_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.399
GSE198165,GSE198166_9_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.83105
Liver cancer stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.59
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
otubain	GeneRIF Biological Term Annotations	1.0	null
GTEX-T5JC-0226-SM-32PMA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862908
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
ML-1	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.57557
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.934958
SMARCB1	ENCODE Transcription Factor Targets	1.0	null
SAP30	ENCODE Transcription Factor Targets	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A762-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Enzastaurin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.013663
GSE97352_3_v_2_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU5F1	ChEA Transcription Factor Targets	1.0	null
POLR2AphosphoS5_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lipomatous cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.714005
LMSU	CCLE Cell Line Gene CNV Profiles	1.0	1.33126
hsa-miR-3136-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
uterine adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.192751
UBE2D2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961862
ANP32A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE139239_2_v_5_ddr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-140-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42244
SIX5	ENCODE Transcription Factor Targets	1.0	null
Fetal_Intestine_Large	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.1122
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.520829
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K94629607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97455
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZR751	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47954
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K89515752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33516
cysteine-type deubiquitinase activity	GO Molecular Function Annotations 2025	1.0	null
TAC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1476
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5124
BRD-K87419143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86429
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36626
PGK1	Pathway Commons Protein-Protein Interactions	1.0	null
transcription	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_MCF10A_48H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.94988
PML	ENCODE Transcription Factor Targets	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.459516
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931032
testis	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08495
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.913885
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.838903
IFNAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32775
HT55	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.07244
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.00581
BRD-K41574232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90859
GSE80446_0_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K13646706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23038
CHTF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884963
BRD-K19502817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48422
PSMA5	Pathway Commons Protein-Protein Interactions	1.0	null
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140607_0_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsalstriatum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.471
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ER ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.721
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.892935
CRCGN015_HEPG2_48H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.28914
SARS-CoV_24Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.65767
NACA	Pathway Commons Protein-Protein Interactions	1.0	null
TMEM150A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22646
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.51313
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.95969
negative regulation of chromatin modification	GO Biological Process Annotations 2015	1.0	null
GTEX-QDT8-0011-R1A-SM-32PKS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950862
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22997
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.66198
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-SYMBOL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
outer CP in midlateral extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.829362
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.83904
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.804
TCF12_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE154577_13_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888869
G22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.91412
K562_Enzastaurin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015428
COQ10A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02551
A549_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021045
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.916659
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SP1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ishikawa cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.606514
PMC12749419-41598_2025_28826_MOESM3_ESM.xlsx-RFT_iBody3_triplicate-Genes_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12069319-Table1.xlsx-OCAB_p40_BirA-Gene_Symbol_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.80673
NALM6	DepMap CRISPR Gene Dependency	1.0	2.23669
RNR2	Hub Proteins Protein-Protein Interactions	1.0	null
CHRNA6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00458986
MTA3	ENCODE Transcription Factor Targets	1.0	null
arm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.272997
BRD-A06327019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27517
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.734012
Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney Chromophobe_KICH_TCGA-KN-8436-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Nasopharyngeal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.312
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-1826-SM-3GILG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915346
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3I0-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29657
BC-00-YH62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.359943
RBPJ-21746931-IB4-LCL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_6228_KO_Mbnl1/Mbnl2_SRP142522	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.24151
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.41306
BRCA1	ENCODE Transcription Factor Targets	1.0	null
KYAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531525
CRCGN015_HEPG2_48H:L02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.24537
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE220520_5_v_4_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SuperiorCervicalGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.22277
nifurtimox-2908	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE129241_4_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Post-translational protein modification	Reactome Pathways 2024	1.0	null
mcf7	HPA Cell Line Gene Expression Profiles	1.0	1.86975
GSE149075_2_v_4_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Upper respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.245
Lung squamous cell carcinoma_LUSC_TCGA-43-8116-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MED14	Pathway Commons Protein-Protein Interactions	1.0	null
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC7764163__F2	PFOCR Pathway Figure Associations 2023	1.0	null
PMC9605952__F2	PFOCR Pathway Figure Associations 2024	1.0	null
hsa-miR-2467-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
BRD-K80880605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17572
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE230656_0_v_1_gsdmd_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72217
GSE165689_0_v_1_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
temporal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.894618
GSE153757,GSE153758_0_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.900324
HSPA1B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-361	GDSC Cell Line Gene Expression Profiles	1.0	1.70026
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SEC23A	Pathway Commons Protein-Protein Interactions	1.0	null
PAX5	ENCODE Transcription Factor Targets	1.0	null
Primary leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.007
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.800478
BRD-K09720842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10304
BRD-K73206088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57536
Perturb_11219_KO_SMYD3_SRP396801	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.4467
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
protein k48-linked deubiquitination	GO Biological Process Annotations 2015	1.0	null
BRD-K54115231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71945
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.6694
cleavage	GeneRIF Biological Term Annotations	1.0	null
digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
CAL-39	COSMIC Cell Line Gene CNV Profiles	1.0	2.76305
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.7384
Nonhomologous end joining complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.745
BRD-K94936556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42147
ELK1	ENCODE Transcription Factor Targets	1.0	null
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.944339
OCILY18	DepMap CRISPR Gene Dependency	1.0	2.5572
CTCF_pancreas_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SBC5_LUNG	CCLE Cell Line Proteomics	1.0	2.98206
FOXA1-33576154-HUMAN-LUNG-PROSTATECANCER	ChEA Transcription Factor Targets 2022	1.0	null
VCP-NPL4-UFD1 AAA ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.145
Plastid	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.803
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
KYSE30	CCLE Cell Line Gene Expression Profiles	1.0	1.38346
SUMO1	Pathway Commons Protein-Protein Interactions	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DA-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USP7	Hub Proteins Protein-Protein Interactions	1.0	null
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.873921
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.767
AR	ChEA Transcription Factor Targets	1.0	null
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.994011
T-REx 293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.994
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
GTEX-WHSE-0011-R11A-SM-3P5YY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830827
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08791
Brain Lower Grade Glioma_LGG_TCGA-FG-8181-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
17638893-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
skin	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.524793
TAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00580072
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWN1-0226-SM-2S1OZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90935
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.242983
BRD-K74198088	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57949
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.46338
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76931
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.858
GTEX-WFG7-0826-SM-3GIKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867573
GSE123825_2_v_3_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
RPLP0	Pathway Commons Protein-Protein Interactions	1.0	null
Multisystem proteinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.201
Lung adenocarcinoma_LUAD_TCGA-91-A4BC-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77241556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28224
E2F1	ChEA Transcription Factor Targets	1.0	null
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05845
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.86533
SNU869	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7269
urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Ubiquitin thioesterase Otubain	InterPro Predicted Protein Domain Annotations	1.0	null
RAF1	MSigDB Cancer Gene Co-expression Modules	1.0	null
ES-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H358 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.596
POLR2A_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE244072_4_v_6_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
protein-processing-post-translational	Phosphosite Textmining Biological Term Annotations	1.0	null
Thyroid gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
RUNX3	ENCODE Transcription Factor Targets	1.0	null
GSE184892_4_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
SARS	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00729
NUDCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-5.41896
ASXL1-24218140-BMDM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX54	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-AML2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.06943
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Proteasome accessory complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.612
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.977039
skin	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.963014
ChIP_H3K36me3_18692474_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
White Blood Cell Count Procedure	DisGeNET Gene-Phenotype Associations	1.0	null
HD-62-KE69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223744
markedly	GeneRIF Biological Term Annotations	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NF-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AF-00-QK19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.573185
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59157
ribonucleoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.251476
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.76076
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878452
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anaphase-promoting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.639
GTEX-NPJ8-1526-SM-2D7VU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20891
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.71459
RNF44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36972
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98903
CTBP2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12081856-41420_2025_2522_MOESM6_ESM.xlsx-Sheet_1-Table_S4_Complete_Gene_List_of_the_MEblack_Gene_Module_and_the_DUB_Family_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K56802897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24873
medial habenular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00901
S0-EE-XMWH_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.333968
GSE231648_1_v_2_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Midgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.29
NUGC-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.830595
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K76135327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68367
smad2	GeneRIF Biological Term Annotations	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-5819-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Squamous Cell Carcinoma Of Esophagus	DisGeNET Gene-Disease Associations	1.0	null
SNU283	CCLE Cell Line Gene CNV Profiles	-1.0	-1.63696
Telson	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.798
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QVUS-0011-R3A-SM-3GAFD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21607
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.86406
BRD-K64763786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06113
Parasitic protozoa infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
cdx2_20696899_caco2_lof_human_gpl570_gse22572	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.109224
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16453
dna metabolic process	GO Biological Process Annotations 2015	1.0	null
estradiol_homo sapiens_gpl96_gse4668	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXO3-22982991-MACROPHAGES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELK4	ENCODE Transcription Factor Targets	1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
HMT-3522 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	0.907131
STAT3	ENCODE Transcription Factor Targets	1.0	null
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
proliferative glomerulonephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.908965
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.967
MEX3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29703
BRD-A94740628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9169
TCF12_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_16689_KO_Il1b_SRP308507	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.45989
PCNA	Hub Proteins Protein-Protein Interactions	1.0	null
macrophage	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23083
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
umbilical cord	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE211177,GSE211178_4_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYOG	ENCODE Transcription Factor Targets	1.0	null
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08171
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.117
Lung squamous cell carcinoma_LUSC_TCGA-66-2778-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC	ChEA Transcription Factor Targets	1.0	null
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931032
GSE211177,GSE211178_4_v_10_ets1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60661821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31977
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K54939987	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11099
GSE158834_10_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83873
RBCK1	Pathway Commons Protein-Protein Interactions	1.0	null
CF-42-OS28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214385
ESYT1	Pathway Commons Protein-Protein Interactions	1.0	null
paclitaxel_homo sapiens_gpl570_gse39042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	2.528
BCLAF1	ENCODE Transcription Factor Targets	1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K49866472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60624
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.35389
Prostate adenocarcinoma_PRAD_TCGA-HC-A6HX-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1833	CCLE Cell Line Gene Expression Profiles	1.0	1.67911
Nerve - Tibial	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.651622
BRD-K58237252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23347
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57454
BRD-K07534805	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20027
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE131798,GSE131804_2_v_0_igf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.26143
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08573
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CEBPB	ENCODE Transcription Factor Targets	1.0	null
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7910580-41467_2021_21715_MOESM3_ESM.xlsx-DUBs_screen-Supplementary_Data_1_Results_of_DUB_shRNA_screen_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
dorsal cochlear nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.79719
EEF2	Pathway Commons Protein-Protein Interactions	1.0	null
suggests	GeneRIF Biological Term Annotations	1.0	null
GTEX-WZTO-2826-SM-3NM8P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10251
ACO2	Pathway Commons Protein-Protein Interactions	1.0	null
Mesothelioma_MESO_TCGA-NQ-A638-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW954	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	1.68744
184B5	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.646568
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898727
hsa-miR-548d-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.444482
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00339
Type IV secretion system complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.96
PMC10319804-41467_2023_38747_MOESM10_ESM.xlsx-circARID1A_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA1-26769127-CHIP-SEQ-PDAC-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
MCF7_2-Methoxyestradiol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0119521
CFPAC1_PANCREAS	CCLE Cell Line Proteomics	1.0	4.92726
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.810679
PMC10061014-Table5.XLSX-C_vs_L-Table_S5a_Results_of_gene-wise_analysis_of_cd-ASE_depending_on_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE231799_2_v_1_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5045
BRD-K43431234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31695
BRCA1-BARD1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.392
MCF7_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0101472
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24081
XPO5	Pathway Commons Protein-Protein Interactions	1.0	null
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.851638
UBE2V1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36923
BRD-K53396471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.61795
GH1	Pathway Commons Protein-Protein Interactions	1.0	null
YY1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.552252
parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GABP-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
TPBGL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71053
BRD-K85977570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0207
BRD-K35462157	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14868
ubiquitin	GeneRIF Biological Term Annotations	1.0	null
GSE146612_1_v_3_amiodarone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.03912
A549_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132812
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.32183
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.837886
CAL-62	GDSC Cell Line Gene Expression Profiles	1.0	1.44103
PGM2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947955
BRD-K37014934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31859
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	2.32589
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43955
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-542-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Silver ion transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.663
Cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.485
hsa-miR-23b	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE134375_0_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10011543-41419_2023_5707_MOESM4_ESM.xlsx-1434_proliferation_genes-ZNF766_ZNF766	Rummagene Transcription Factor Associations 2026	1.0	null
GSE168401_1_v_3_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IKBKG	Pathway Commons Protein-Protein Interactions	1.0	null
GSE198165,GSE198166_8_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K97839095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06003
MCF7	BioGPS Cell Line Gene Expression Profiles	1.0	1.97571
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
P68-20966046-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_14248_KD_HNRNPC_SRP353785	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.30163
BRD-K33204113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6959
GSE143212_0_v_3_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ribosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.239197
BRD-K78615842	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15043
L33_PANCREAS	CCLE Cell Line Proteomics	1.0	2.78222
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917354
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.66179
Stomach carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
amygdaloid complex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.875794
a549	HPA Cell Line Gene Expression Profiles	1.0	1.61994
HDAC1	ENCODE Transcription Factor Targets	1.0	null
CC-55-CD84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.254981
Psoriasis vulgaris_Skin tissue_GSE6710	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.58204
PMC4944136-srep28995-s2.xls-DPRX-gene_DPRX	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10993426__F3	PFOCR Pathway Figure Associations 2024	1.0	null
BRD-K45037973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02175
hsa-miR-4271	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.56761
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19459
SG in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.45275
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE150134_1_v_0_scn5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO-818	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.15467
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0949
CRCGN015_HEPG2_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.19436
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.25309
BRD-K73531877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03356
FOXO3	ChEA Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3421-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100322_FWM_possible Alzheimer's disease_no TBI_100+_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.17898
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
KAT2A	ENCODE Transcription Factor Targets	1.0	null
CCT7	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.897017
GSE158834_7_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4664-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
cysteine-type peptidase activity	GO Molecular Function Annotations 2025	1.0	null
extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.057922
CRCGN013_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21615
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44275
HCT-116	COSMIC Cell Line Gene Mutation Profiles	1.0	null
breakinduced	GeneRIF Biological Term Annotations	1.0	null
EEF1A1	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.092
outer CP in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.928136
Left ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.3
Mre11 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.502
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054826
kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
scale	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.221521
Salivary gland adenoid cystic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
Fine root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.301
BRD-K82107155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21797
GTEX-WWYW-0426-SM-3NB31	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882856
PRUNE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24167
mapk	GeneRIF Biological Term Annotations	1.0	null
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.489495
MAP3K7_knockdown_37_GDS5023	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.27646
hsa-miR-661	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
NFIC	ENCODE Transcription Factor Targets	1.0	null
ishikawa	GeneRIF Biological Term Annotations	1.0	null
Inflammation	CTD Gene-Disease Associations	1.0	1.27689
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.563476
A549_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143709
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.85255
GABPA_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7911352__F2	PFOCR Pathway Figure Associations 2024	1.0	null
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BT474	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.47163
PMC6828713__F1	PFOCR Pathway Figure Associations 2023	1.0	null
H3K36me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45348630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0953
SIRT6_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1143	DepMap CRISPR Gene Dependency	1.0	3.27174
BRD-K63957636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32461
primary visual cortex (striate cortex, area V1/17)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.15393
PARP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2783
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.865424
CAL 27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.36445
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K29086754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43894
SMZ1	DepMap CRISPR Gene Dependency	1.0	2.74635
GSE137144_2_v_0_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.514825
SNU-638	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45985
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
protein modification by small protein removal	GO Biological Process Annotations 2025	1.0	null
FERMT2	Pathway Commons Protein-Protein Interactions	1.0	null
NME2	MSigDB Cancer Gene Co-expression Modules	1.0	null
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207396
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_10_v_6_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277324
otub1	GeneRIF Biological Term Annotations	1.0	null
TDP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65246
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
after	GeneRIF Biological Term Annotations	1.0	null
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149261
PMC4975902-12864_2016_2842_MOESM12_ESM.xlsx-targets_of_IRF8_in_NSCLC-COX7C_IRF8	Rummagene Transcription Factor Associations 2026	1.0	null
GSE179002_0_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17678
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896767
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.266757
yersinia	GeneRIF Biological Term Annotations	1.0	null
BRD-K64665523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00371
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00226
PSMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.70029
GSE228181_2_v_5_idh1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.268137
spinal trigeminal nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.872867
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1794
USP7	Pathway Commons Protein-Protein Interactions	1.0	null
MGE-Lateral region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.05808
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52765
BRD-K76616863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24848
GSE188870,GSE188871_1_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.326
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T5-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCM5	Pathway Commons Protein-Protein Interactions	1.0	null
SF3B1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
negative regulation of protein k63-linked ubiquitination	GO Biological Process Annotations 2015	1.0	null
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31816
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K53752646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01791
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.27019
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41118
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.862826
TAF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IH-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Appendix	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.04359
NUGC-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844684
ESCRT-0 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.996
spinal trigeminal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.956155
SPI1-22096565-GC-B-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K30803694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09429
Lewy body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.093
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.900861
GTEX-X88G-0126-SM-47JZ3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908108
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20993
GSE175787_5_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42213
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09563
BRD-K78500251	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.639
Glutamate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.769
BRD-K52973286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1851
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.757
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07223
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormality of cellular immune system	GWASdb SNP-Phenotype Associations	1.0	0.157825
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	1.0	1.25027
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-19-JA87_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33247
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
negative regulation of histone H2A K63-linked ubiquitination	GO Biological Process Annotations 2023	1.0	null
CRCGN015_MCF10A.TP53.M_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70422
Brain Lower Grade Glioma_LGG_TCGA-QH-A65X-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46702
Endometriosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
BRD-K20733942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12602
Sec62/Sec63 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.683
stability	GeneRIF Biological Term Annotations	1.0	null
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4823
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
Osteosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.182
t47d	HPA Cell Line Gene Expression Profiles	1.0	1.15295
BRD-K45153693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68181
hsa-miR-708	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IM-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K66690073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1748
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VAPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3698
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.522
betulin-2952	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cytoplasmic ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.649
respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
negative regulation of double-strand break repair	GO Biological Process Annotations 2015	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53187
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZQ-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glutaminase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.995
gtpase	Phosphosite Textmining Biological Term Annotations	1.0	null
SYNCRIP	Pathway Commons Protein-Protein Interactions	1.0	null
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CAL27	CCLE Cell Line Gene CNV Profiles	1.0	1.78399
TRAF6	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0298
cysteine-type deubiquitinase activity	GO Molecular Function Annotations 2023	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
TARBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31023
PR-DUB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.293
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12677
NCI-H23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.36735
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE211983_1_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ANXA9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00679204
NCI-H292	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49214
BRD-A44068497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03418
outer CP in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18404
PMC12014030-medi-104-e42146-s001.pdf-0-STAT3_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12238561-42003_2025_8460_MOESM2_ESM.xlsx-IDs_S16_LF_C2_8h-Unnamed_5_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.37876
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29381
SIRT6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5988
abnormal lung morphology	MGI Mouse Phenotype Associations 2023	1.0	null
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MYCN-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
allow	GeneRIF Biological Term Annotations	1.0	null
AD-06-OB47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.658608
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.47245
GSE213632_3_v_6_acod1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE212312_1_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996092
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Turion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.685
vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12254341-41467_2025_60760_MOESM3_ESM.xlsx-MR_of_flat_vs_pillar_D_ipp-Gene_names_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
basis	GeneRIF Biological Term Annotations	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06386
PRDM1	ENCODE Transcription Factor Targets	1.0	null
PMC9323628__F3	PFOCR Pathway Figure Associations 2024	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ESR1-26153859-MCF-7-HUMAN-BREASTCANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K71590663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90142
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A23K-01A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.08467
CAOV-3 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.613
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J2-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Clathrin coat of trans-Golgi network vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.3
molecular layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.831154
THAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2199
hsa-miR-4725-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
PBX3	ENCODE Transcription Factor Targets	1.0	null
Perturb_3487_KO_Kctd13_ERP112326	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.36024
NHLH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48031
PRDM1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4918
BRD-K55169051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06342
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.509
H4K20me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28117
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055555
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A5W4-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14484
PK-45P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04506
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03351
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.941284
BRD-A55408860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.184
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.634535
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MKN-28 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.635
CRCGN015_HEPG2_48H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.47737
Colon Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.512
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.89873
Bronchogenic carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.722
MDAMB415	DepMap CRISPR Gene Dependency	1.0	2.09042
Salivarygland	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.00952
GTEX-QCQG-0426-SM-48U29	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91692
C6orf211	Pathway Commons Protein-Protein Interactions	1.0	null
TUBB4B	Pathway Commons Protein-Protein Interactions	1.0	null
K-562 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	1.0	1.77259
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02148
NPEPPS	Pathway Commons Protein-Protein Interactions	1.0	null
mhhes1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.944
BRD-K94014790	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72667
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
496100496_FWM_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.16324
Hedgehog signaling complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.82
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266117
pathways	GeneRIF Biological Term Annotations	1.0	null
BRD-K06519744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02456
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053234
Peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.578
em3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.626
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72177
CE-23-HP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.24516
GTEX-NL3H-0011-R7a-SM-2I3G5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42277
ubiquitylation	GeneRIF Biological Term Annotations	1.0	null
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.259963
BRD-K36537572	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22345
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BCLAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.835759
substantia innominata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.917323
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.355197
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70861
GSE240896,GSE240899_10_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X5EB-2226-SM-46MW4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947152
H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.296359
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1138
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27772
NCI-H810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.941284
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.922504
GTEX-XOTO-0726-SM-4B659	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853164
BRD-K63887881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50173
PLCB3	Pathway Commons Protein-Protein Interactions	1.0	null
YMB1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58874
BRD-K04928505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65618
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04857
GTEX-XPVG-2126-SM-4B667	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82399
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193993_5_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34483
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.69879
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.940178
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.98037
NCI-H1155	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ACTN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00483788
IZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.833983
NCI-H716	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21118
ATIC	Pathway Commons Protein-Protein Interactions	1.0	null
GSE198165,GSE198166_8_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7884719-41598_2021_83348_MOESM3_ESM.xlsx-female_port-FOS_1_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17492
BRD-K23553911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75602
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE121824,GSE121826_0_v_6_scaf8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
T3M4	BioGPS Cell Line Gene Expression Profiles	1.0	0.86498
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01983
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.13317
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14023
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	2.52549
AE-18-ZM98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229101
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
RNF2	Pathway Commons Protein-Protein Interactions	1.0	null
GSU	CCLE Cell Line Gene CNV Profiles	-1.0	-2.48717
Perturb_10924_KO_Nfe2l2_SRP297449	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.38509
head of caudate	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.2487
GTEX-U8T8-0126-SM-3DB94	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27422
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9499
ALDH18A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00395498
GSE153484_2_v_0_foxp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7167
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05788
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
flumethasone-pivalate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75393
positive regulation of TORC1 signaling	GO Biological Process Annotations 2025	1.0	null
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.8618
BRD-K00914921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97655
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K26383086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20387
UBE2D1	Pathway Commons Protein-Protein Interactions	1.0	null
promotes	GeneRIF Biological Term Annotations	1.0	null
fat_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.856146
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IQ-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
negative regulation of DNA repair	GO Biological Process Annotations 2023	1.0	null
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135391
ZEB1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.013
HS255T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51521
ovariole	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.55698
COLO-678	GDSC Cell Line Gene Expression Profiles	1.0	2.63713
Pyloric cecum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.906
K562_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0167499
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
protein modification process	GO Biological Process Annotations 2015	1.0	null
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35274
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.981671
PYGB	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-94-7033-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GPR161	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16452
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DDB1	MSigDB Cancer Gene Co-expression Modules	1.0	null
GADD45GIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21262
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27195
PMC3999155__F6	PFOCR Pathway Figure Associations 2024	1.0	null
GABPA_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_2-Methoxyestradiol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140846
specificity	GeneRIF Biological Term Annotations	1.0	null
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.836351
BRD-K55160477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17744
brain	GTEx Tissue Gene Expression Profiles	1.0	1.43805
BRD-K49742819	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51264
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.436662
host	GeneRIF Biological Term Annotations	1.0	null
JHH5	CCLE Cell Line Gene Expression Profiles	1.0	1.58159
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14575
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
central nuclear group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.958125
GSE201217_4_v_6_usf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71671197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42341
CAL27	CCLE Cell Line Gene Expression Profiles	1.0	2.17583
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.489327
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SNU620	DepMap CRISPR Gene Dependency	1.0	2.7113
BRD-K13852343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11903
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.058708
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1755
NR3C2-34362910-WISTARRAT-HIPPOCAMPUS-STRESS	ChEA Transcription Factor Targets 2022	1.0	null
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.876173
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.04088
T-47D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5601
Perturb_3473_KO_Cox6a2_ERP114839	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.78998
negatively	GeneRIF Biological Term Annotations	1.0	null
GSE137818_3_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.15207
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-WT-gene_symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
NAF1	Hub Proteins Protein-Protein Interactions	1.0	null
GSE240027,GSE240030_5_v_3_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPS19	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA9	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952443
RAB7A	Pathway Commons Protein-Protein Interactions	1.0	null
GSE171179,GSE171181_0_v_1_e7107_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glioma stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.945
hsa-miR-4461	TargetScan Predicted Conserved microRNA Targets	1.0	0.099701
GSE164757,GSE164759_4_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.08298
pyrantel-pamoate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02406
Ripoptosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.013
TKT	Pathway Commons Protein-Protein Interactions	1.0	null
496100352_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.487
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.981617
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Colorectal Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
SMARCB1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.867067
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Heat_LPStoThermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
KMS26	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78103
CSNK1D	MSigDB Cancer Gene Co-expression Modules	1.0	null
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TNIK	Hub Proteins Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF2-27304074-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Perturb_17493_KO_Gpr115_SRP275685	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.68922
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.47661
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.907373
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12643
opm2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.548
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AA-52-JS03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.410812
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23548
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
succinylcholine-chloride	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07168
Malignant exocrine pancreas neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.682529
H513	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2AphosphoS2_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
tonsil_8e1	HPA Tissue Sample Gene Expression Profiles	1.0	1.00274
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.616979
TC106	DepMap CRISPR Gene Dependency	1.0	3.56007
Integumentary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
CPNE7	Pathway Commons Protein-Protein Interactions	1.0	null
CB-32-EI69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.207229
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.987977
RPS16	Pathway Commons Protein-Protein Interactions	1.0	null
3381_GKAP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.544649
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86603
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.870461
RACK7-27058665-CHIP-SEQ-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Skin	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.07871
BRD-K86995890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25272
SNU878	CCLE Cell Line Gene Expression Profiles	-1.0	-2.34986
Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A94366206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29388
trans-Golgi network transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.282
Pharynx cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
cystocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.5594
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
septal nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.14992
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MALME 3M	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.77015
CTCF_GM12874_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prp19 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.243
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2789
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.64001
BRD-K61560971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97364
RPS11	Pathway Commons Protein-Protein Interactions	1.0	null
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	1.0	null
DAGLB	Pathway Commons Protein-Protein Interactions	1.0	null
KLF4-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PRDM1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ubiquitin binding	GO Molecular Function Annotations 2015	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SF539	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-3.38233
PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_POU2AF1	Rummagene Transcription Factor Associations 2026	1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
QA-34-PH05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239837
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K29130550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03706
MCF7_Capecitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154335
Lung squamous cell carcinoma_LUSC_TCGA-85-8582-01A-21R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUMO-targeted ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.81
BRD-K76337122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17416
AB-21-VE32_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.249458
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43547
BRD-K74482064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17335
down syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.390397
negative regulation of histone modification	GO Biological Process Annotations 2015	1.0	null
CRCGN015_MCF10A.WT.HP_24H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76105
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
BRD-K88758204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65539
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hindgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.264
ACLY	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K41396351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39478
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE210655_1_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Acute leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AP-4	MotifMap Predicted Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-64-1676-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QE-79-XO29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.707388
SPI1-20176806-THIOMACROPHAGE-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947109
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_NANOG_targets_Boyer_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
response to stress	GO Biological Process Annotations 2015	1.0	null
cysteine	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Heat_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
extracellular vesicular exosome	GO Cellular Component Annotations 2015	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
UFD1-NPL4 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.125
CFL1	Pathway Commons Protein-Protein Interactions	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
inhibition	GeneRIF Biological Term Annotations	1.0	null
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TFAP2A	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC3669416-pone.0064838.s001.xls-mHTT-HOXD10_HOXD10	Rummagene Transcription Factor Associations 2026	1.0	null
GSE166944_3_v_2_eif4b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_6358_KO_NumbL_SRP307901	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.43559
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A26D-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K69347147	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40515
protein deubiquitination	GO Biological Process Annotations 2025	1.0	null
NR2F2	ENCODE Transcription Factor Targets	1.0	null
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.393289
PMC7804490__F2	PFOCR Pathway Figure Associations 2023	1.0	null
BRD-K05639803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13937
GSE135514_2_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
proxyphylline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71027
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7541
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
glomerulonephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.205254
TFAP2C	ChEA Transcription Factor Targets	1.0	null
GSE146894_3_v_8_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ATG5	Pathway Commons Protein-Protein Interactions	1.0	null
EZR	Pathway Commons Protein-Protein Interactions	1.0	null
CS	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.03567
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41162
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.74169
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ARPC4	Pathway Commons Protein-Protein Interactions	1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.13187
regulated	GeneRIF Biological Term Annotations	1.0	null
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08743
GSE166184,GSE166185_1_v_0_sox2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.55015
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39292
TAF7	ENCODE Transcription Factor Targets	1.0	null
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.713723
germ layer	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28316
ANXA7	Pathway Commons Protein-Protein Interactions	1.0	null
SHMT2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cullin-RING ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.794
ATF2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
INPP4B	Pathway Commons Protein-Protein Interactions	1.0	null
9910_XRN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.518869
KDM5A	ChEA Transcription Factor Targets	1.0	null
SOWAHC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00541614
BRD-K03353688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18057
primary auditory cortex (core)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.952039
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F4_E2F4	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.99504
ABAT	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OIZG-0726-SM-33HBL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15185
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
Multiple myeloma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.663
BRD-K95018971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37993
BRD-K87044635	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35499
TFAP2A-35110662-HEPM-HUMAN-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0614
hsa-let-7e-5p	MiRTarBase microRNA Targets	1.0	null
MYC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.858272
Mitochondrion	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.411
inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17841
SIN3A	ChEA Transcription Factor Targets	1.0	null
BRD-K06935782	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71844
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0183423
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
PSMB2	Pathway Commons Protein-Protein Interactions	1.0	null
GID complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.712
Parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33181
PMC12271601-mmc2.xlsx-OUT_cells_02-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
CHLA266	DepMap CRISPR Gene Dependency	1.0	2.94088
ETS1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.877473
GSE211983_0_v_3_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
regulate	GeneRIF Biological Term Annotations	1.0	null
IKBKB_knockdown_86_GSE27869	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.91428
16247463-Table2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-POYW-0726-SM-2XCEO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.333
4578_LIG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.79361
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Site of DNA damage	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.485
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22081
LUBAC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.202
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900383
BRD-K93210276	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25781
Perturb_1885_KO_Mettl14_SRP269254	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.05158
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE203308_4_v_3_brf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P44H-2426-SM-2XCEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10327
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36292
CHD7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
interactions	GeneRIF Biological Term Annotations	1.0	null
Copper ion transmembrane transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.663
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VCP	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11781159-ijbsv21p1174s1.pdf-4-ATF4_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CSNK2A1	PhosphoSitePlus Substrates of Kinases	1.0	null
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
negative regulation of histone ubiquitination	GO Biological Process Annotations 2023	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE217105_0_v_1_gemcitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Sodium Phenylbutyrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018956
5470_NAT10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10912
GTEX-T5JC-0526-SM-32PM7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87679
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.5807
FOXO3-22982991-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
protein modification by small protein removal	GO Biological Process Annotations 2015	1.0	null
GSE225141,GSE225143_2_v_3_mettl3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SNU245	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
H3K36me3_bronchial epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_6956_KO_Tefm_SRP114827	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.97583
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-EGR1_DC_ChIP-seq_EGR1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K52520268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34956
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SA1-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
nucleic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
peptidase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	2.29966
ATF3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9950457-mmc3.xlsx-AP2A_binding_sites_GRHL2_KO-LRRC32_GRHL2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K36me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096374
BRD-K20024676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01521
BT-549 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.878
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.979
JAG1_OE_GDS3571_40_human_endometrial stromal cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.06574
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.18444
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Atherosclerosis_Aorta Smooth Muscle Tissue_GSE420	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-0.989839
GTEX-NL4W-0011-R2a-SM-2I5GV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863009
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Obesity_Muscle - Striated (Skeletal) (MMHCC)_GSE474	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.52
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
negative regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
YBX1	Pathway Commons Protein-Protein Interactions	1.0	null
ARF1	Pathway Commons Protein-Protein Interactions	1.0	null
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.923103
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Y-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182179_2_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8528285-pbio.3001085.s010.xlsx-Fig_S7B-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_WT_TESTES_874_GENES_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
BL1921 (KIAA1967)	NURSA Protein Complexes	1.0	null
YBX3	Pathway Commons Protein-Protein Interactions	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PX-01A-51R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2073	CCLE Cell Line Gene CNV Profiles	-1.0	-1.96499
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846401
internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08305
Fanconi anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.56
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE240386,GSE242143_1_v_4_morc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7B0-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
chromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.349105
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
k29	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.783
OE-84-HO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385394
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JW-A852-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10168
RVH421SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.09075
BRD-K34110797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88979
abnormality of leukocytes	GWASdb SNP-Phenotype Associations	1.0	1.15966
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10386
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	3.07468
MLF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00748
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XXEK-2226-SM-4BRUM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854792
GTEX-SN8G-0126-SM-32PLI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965324
embryo	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.537
negative regulation of histone h2a k63-linked ubiquitination	GO Biological Process Annotations 2015	1.0	null
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09101
BRD-K55508908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5444
GTEX-X62O-1626-SM-46MW9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87569
PMC9314667-Table_1.xlsx-Regulons-ETV4_ETV4	Rummagene Transcription Factor Associations 2026	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.376
SKMEL2	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.00761
TFAP2A	ENCODE Transcription Factor Targets	1.0	null
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
ACAA1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
otub2	GeneRIF Biological Term Annotations	1.0	null
heterocycle metabolic process	GO Biological Process Annotations 2015	1.0	null
regulation of response to dna damage stimulus	GO Biological Process Annotations 2015	1.0	null
BRD-K25330450	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13461
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.68132
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.987843
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7653
H3K4me1_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26115
Methyl accepting chemotaxis protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.765
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06033
medial vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.2682
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.840273
dg1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
regulation of nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
enhances	GeneRIF Biological Term Annotations	1.0	null
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	1.0	null
ADH1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00640944
Proteasome core complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.766
sr96	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.455
hscarg	GeneRIF Biological Term Annotations	1.0	null
free	GeneRIF Biological Term Annotations	1.0	null
MYH10	Pathway Commons Protein-Protein Interactions	1.0	null
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.33307
Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.542
Death	CTD Gene-Disease Associations	1.0	1.14098
kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.087851
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39476596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12584
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
trazodone-2379	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
drofenine-2714	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GABP-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7066_KO_Lrpprc_SRP110979	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.61492
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.988557
Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24166534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45289
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tail of caudate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.922058
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A766-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08476
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BR-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
immune	Phosphosite Textmining Biological Term Annotations	1.0	null
primary motor cortex (area M1, area 4)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.24069
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Polar nucleus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.595
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
deNEDDylase activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K47087435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00146
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.05538
CEBPD	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.598
viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.1936
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFX	Pathway Commons Protein-Protein Interactions	1.0	null
ubiquitin-like protein ligase binding	GO Molecular Function Annotations 2023	1.0	null
Phloem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.839
IRF1	ENCODE Transcription Factor Targets	1.0	null
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1	ChEA Transcription Factor Targets	1.0	null
SPI1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44431
ES2	CCLE Cell Line Gene CNV Profiles	1.0	1.4427
BRD-K07350528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2204
KYNU	Pathway Commons Protein-Protein Interactions	1.0	null
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USP28	Pathway Commons Protein-Protein Interactions	1.0	null
type	GeneRIF Biological Term Annotations	1.0	null
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
GSE120756_2_v_9_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
esculetin-3120	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE130956_2_v_1_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.765
18722011-SuppTable2m	GeneSigDB Published Gene Signatures	1.0	null
GSE169205_4_v_7_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KPL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.954417
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE184892_7_v_2_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1793	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-A5DJ-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10898050-12967_2024_4947_MOESM2_ESM.xlsx-Table_S7-Table_S7_Differentially_expressed_genes_between_the_TCF7_CD8_memory_T_cells_and_the_other_memory_CD8_T_cells_TCF7	Rummagene Transcription Factor Associations 2026	1.0	null
EPLC-272H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846401
GSE142430_3_v_0_prmt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K82102352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25119
SKNSH	DepMap CRISPR Gene Dependency	1.0	2.77092
Calu-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.816
regulation of protein polyubiquitination	GO Biological Process Annotations 2015	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6491-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18744
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29V-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423273
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8185
STAMBP	Pathway Commons Protein-Protein Interactions	1.0	null
MAX_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GB-46-CK08_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289019
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40775
ubiquitin protein ligase binding	GO Molecular Function Annotations 2025	1.0	null
CSE1L	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5	Rummagene Transcription Factor Associations 2026	1.0	null
TGBC18TKB	DepMap CRISPR Gene Dependency	1.0	2.10866
SYK_druginhibition_153_GSE34176	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.64108
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5565
Pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.357
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
AB-97-BI36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.404664
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Mocetinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142202
GSE239747_2_v_3_lrp6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC70	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.27671
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846401
PMC4441763__F4	PFOCR Pathway Figure Associations 2024	1.0	null
TFAP2C	ENCODE Transcription Factor Targets	1.0	null
GSE167886_2_v_1_chd7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
coronary artery disease	GWASdb SNP-Disease Associations	1.0	0.463263
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.320442
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06418
DNA ligase IV complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.839
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
BRD-K21610715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02663
HADHB	Pathway Commons Protein-Protein Interactions	1.0	null
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.31946
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Multiple myeloma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.0
dorsomedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.82429
BRD-K97393725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09282
BE-27-RQ61_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.15148
hsa-miR-3179	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.69571
abnormal heart position or orientation	IMPC Knockout Mouse Phenotypes	1.0	null
regulation of histone modification	GO Biological Process Annotations 2015	1.0	null
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.40529
TE4	CCLE Cell Line Gene Expression Profiles	1.0	1.35171
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-0.98833
AP-type membrane coat adaptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.059
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
tumour	Phosphosite Textmining Biological Term Annotations	1.0	null
Perturb_3_KO_Cnot6l_SRP152802	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.124
RHOA	Pathway Commons Protein-Protein Interactions	1.0	null
HSPD1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE155852_0_v_2_apigenin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K03344897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08167
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
BRD-K87875370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62678
Lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
temporal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1502
Lung squamous cell carcinoma_LUSC_TCGA-52-7810-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182680,GSE182683_10_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7887
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	253.38
IFNA21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00341811
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6003-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.23454
IKBKG	MSigDB Cancer Gene Co-expression Modules	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
single-organism process	GO Biological Process Annotations 2015	1.0	null
FAM118B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06979
Huntington's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.179
IGROV1	BioGPS Cell Line Gene Expression Profiles	1.0	0.893311
CTCF_WERI-Rb-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE153757,GSE153758_1_v_3_ftsj1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4761-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.286
TFAP2C-20629094-MCF7-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
lateral orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.82797
stabilization	GeneRIF Biological Term Annotations	1.0	null
GTEX-WFON-0326-SM-3GIKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05291
MAVS	Pathway Commons Protein-Protein Interactions	1.0	null
GSE140607_1_v_6_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3118	DepMap CRISPR Gene Dependency	1.0	2.91919
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.34665
Adipose - Visceral (Omentum)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.77145
recruitment	GeneRIF Biological Term Annotations	1.0	null
GSE143847_2_v_3_inhba_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48301
E2F6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-RC-A6M6-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PBX3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC4994957-pbio.1002539.s014.xlsx-DUB_screen_results-closest_Hsap_ortholog_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
VMCUB1	CCLE Cell Line Gene Expression Profiles	1.0	1.77219
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.826
UBR5	Pathway Commons Protein-Protein Interactions	1.0	null
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1892
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.51082
BRD-K96817767	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0287
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K13551202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28112
BRD-K38970027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56474
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25432
ETS1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bile duct cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
into	GeneRIF Biological Term Annotations	1.0	null
HEK-293ET cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
BRD-K44309337	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24855
cingulate gyrus, retrosplenial part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.33502
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43674766	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04889
CTCF_GM12866_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5SP-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75815721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19491
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00182
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.30848
Acute Myeloid Leukemia_LAML_TCGA-AB-2977-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Uterine endometrial cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.864
Plume	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.575
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
TOR1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30528
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39639
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
ap92	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.689
Endoplasmic reticulum quality control compartment	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.827
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
RPS25	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KMS20	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49019
ES-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04909
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.363
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TPM1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K57173429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14077
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.888527
BRD-K26786741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38891
UC-00-QA88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.312603
Colon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE144115_1_v_3_stag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SIN3A-21632747-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
negative regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63547
BRD-K98625375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14882
GSE210655_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02534
hsa-miR-2110	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A116-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8816717-mmc2.xlsx-TgCRND8_P113-Unnamed_2_STAT2	Rummagene Transcription Factor Associations 2026	1.0	null
SW-620 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.91
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.517
MCF7_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134285
GTEX-WFJO-1026-SM-3GIKL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29599
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.618603
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.983713
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.02919
PMC9235320-mmc2.xlsx-ST9_eQTL-MR-results-Unnamed_1_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NPJ7-2726-SM-2I3FT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02177
proteolysis	GO Biological Process Annotations 2015	1.0	null
BCL3-23251550-MUSCLE-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SIX5_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A4AC-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.923
BA-15-LA22_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.7344
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.791
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MT-A51X-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CC-68-YZ44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322013
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.844684
t61-colon_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.47197
PREX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00468097
GSE146982_3_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.458504
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H322T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.7922
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.44184
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
ATF2	ENCODE Transcription Factor Targets	1.0	null
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64107
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45302
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM25	Pathway Commons Protein-Protein Interactions	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
Ovarian Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.978344
mesalazine-6162	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MN-0011-R1A-SM-32QOY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60818
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.27434
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29946
BRD-K52372795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11973
GSE230329_0_v_3_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.399363
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A172_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	2.49802
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.20872
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49B-01A-31R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33244
b16melanoma4a5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.556
GABPA_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MEL-HO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.3225
GSE164521_0_v_1_nitric oxide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6628
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14474
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hindgut	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.556467
DOK	DepMap CRISPR Gene Dependency	1.0	2.10178
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.323907
lung	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
BRD-K89364982	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08581
Haustorium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.613
SAGA-type complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.506
hsa-miR-708-3p	MiRTarBase microRNA Targets	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lp1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.093
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ChIP_JARID1A_20064375	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970766
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-324-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
PMC8384902-mmc2.xlsx-3_ASCL1_high_subtype-Gene_Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rostral migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13635
BRD-K84514454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45979
transient	GeneRIF Biological Term Annotations	1.0	null
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.941396
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.012
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N8-A56S-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HSPE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02823
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.20567
AA-23-FM46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258251
negative regulation of dna metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994654
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K67016489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93106
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09763
PPARG	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
phenacemide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41946
GTEX-N7MS-0626-SM-2YUN7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965085
Perturb_10696_KD_Gls2_SRP326675	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.41386
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
embryonic structure	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
CUL3	Pathway Commons Protein-Protein Interactions	1.0	null
SPI1-22790984-ERYTHROLEUKEMIA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE137818_5_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-1012-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hemolymph	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.520829
Mesothelioma_MESO_TCGA-TS-A7PB-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR2C2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Panicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.544
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.49014
A549_Decitabine_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0114481
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995898
S0-EE-Y4UM_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.476311
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
PKLR	Pathway Commons Protein-Protein Interactions	1.0	null
midbrain reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06051
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Esophageal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.506
BRD-K66089377	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56098
ubiquitins	GeneRIF Biological Term Annotations	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14178
CAD	Pathway Commons Protein-Protein Interactions	1.0	null
HUVEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.22388
MCF7_SGI-1776 free base_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136593
CRCGN008_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0616
BRD-K74096348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17443
Ubiquitin conjugating enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.637
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Plague	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.004
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CMG complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.659
PMC3938679-pone.0090284.s007.pdf-22-ZBTB20_ZBTB20	Rummagene Transcription Factor Associations 2026	1.0	null
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.55351
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20215
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6840-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K25773863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0394
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.963
viral	GeneRIF Biological Term Annotations	1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.081446
RPE1SS48	DepMap CRISPR Gene Dependency	1.0	2.03193
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.731
PMC3669416-pone.0064838.s001.xls-mHTT-HOXD8_HOXD8	Rummagene Transcription Factor Associations 2026	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
MCF7_Tranylcypromine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146564
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.552
BRD-K03370561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63533
A498	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.55639
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
primary motor cortex (area M1, area 4)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22783
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.323144
MCF7_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140318
TEAD4	ENCODE Transcription Factor Targets	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6796-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K96096022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37498
Skin cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	1.0	null
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055956
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10569
PRKAB1	Pathway Commons Protein-Protein Interactions	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.46
UBA52	Pathway Commons Protein-Protein Interactions	1.0	null
Transforming growth factor beta activated kinase 1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.222
bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075252
Caki-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.945
MDAMB134VI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.85566
CNOT8	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA5	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38126
H3K36me3_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97784715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02047
POLR2AphosphoS5_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Plasma membrane respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.971
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13878
ovary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.537021
BRD-K73319967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94516
GSE173201_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.037219
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.452301
BRD-K27621887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63841
TNIK	Pathway Commons Protein-Protein Interactions	1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.841
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EM-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87358945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18335
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sensory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
K562_GSK1070916_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0219028
Lung squamous cell carcinoma_LUSC_TCGA-77-8140-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cells - Cultured fibroblasts	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.661185
ChIP_ZFX_18555785	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.12107
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SMOX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00663029
Cytosolic proteasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.032
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K07914894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41472
GSE128333_2_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K31716785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31303
HDAC2	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.889873
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AV-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CE-20-VA70_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396082
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887722
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV0-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE116930,GSE116935_3_v_0_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTF2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50224
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.56754
MRPL58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20056
MYC-18358816-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Vegetative stage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A60487173	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5323
GSE139120_1_v_0_urod_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
glutamate-cysteine ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.424
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QF-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A04975445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00623
BRD-K04939366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31632
H3K79me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-4.16559
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K41887762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23176
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19847
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25911
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04134
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52814
MCF7_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140017
MCF7_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0109794
brain	HPA Tissue Gene Expression Profiles	1.0	0.932159
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TU-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UTHO-1026-SM-3GAF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01033
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF4A1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K45508763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15738
BRD-K30699866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93224
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.307509
SkeletalMuscle	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.859716
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.96751
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.846401
ATRFLOX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4290	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
BRD-K06049932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43614
hepatitis b	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.226607
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54742099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18584
ATP5B	Pathway Commons Protein-Protein Interactions	1.0	null
THAP1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lymphoid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Ferritin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.469
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10201
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.484715
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235701,GSE261434_0_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GANAB	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SC-50347 (PIAS4)	NURSA Protein Complexes	1.0	null
hsa-miR-4708-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.11881
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999045
ZR75_1	BioGPS Cell Line Gene Expression Profiles	1.0	0.957682
PMC4443431-main.nxml--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Diseases	CTD Gene-Disease Associations	1.0	1.03456
BRD-K20415826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18608
hsa-miR-23a	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
FOXP2_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78367
ipi1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.683
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07092
BT474	CCLE Cell Line Gene CNV Profiles	1.0	1.86732
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1167
Albedo	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.639
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1-20517297-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20875
FASN	Pathway Commons Protein-Protein Interactions	1.0	null
Lupus Nephritis	DisGeNET Gene-Disease Associations	1.0	null
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59744424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6157
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
TUBA1B	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931032
BRD-K20009653	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97141
DNA replication preinitiation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.747
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.19
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC2853371__F9	PFOCR Pathway Figure Associations 2024	1.0	null
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FF-86-NH56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.522316
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143632
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9389
VCL	Pathway Commons Protein-Protein Interactions	1.0	null
MXI1_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_SIN3A_21632747	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
structural	GeneRIF Biological Term Annotations	1.0	null
C-33 A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.24254
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LBHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.44102
BRD-K57782577	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14948
624 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1815
PMC10209342-mmc9.xlsx-UBE2D3_interactors-UBE2D3_interactors_used_for_Venn_Diagrams_from_MINT_STRING_UniProt_IntAct_BioGRID_SPEN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125219,GSE125221_4_v_2_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.899397
uncharged	GeneRIF Biological Term Annotations	1.0	null
BRD-K92356128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.54637
Bile duct adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
GSE201042_6_v_4_ptpmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TTLL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62114
CECR5	Pathway Commons Protein-Protein Interactions	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01043
TP63	ChEA Transcription Factor Targets	1.0	null
Golgi-associated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.091
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.980384
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206270_1_v_0_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of protein modification process	GO Biological Process Annotations 2015	1.0	null
KPNB1	Pathway Commons Protein-Protein Interactions	1.0	null
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
IL36RN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568086
lm9	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.555
GSE136238_1_v_2_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.72941
FB-66-UU47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360493
PNISR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15882
Patu-8988 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.871
HNRNPA2B1	Pathway Commons Protein-Protein Interactions	1.0	null
MEL-JUSO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.830991
GSE211177,GSE211178_0_v_1_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chromatin	GeneRIF Biological Term Annotations	1.0	null
SW-480 cell	ProteomicsDB Cell Type and Tissue Protein Expression Profiles	-1.0	-1.21613
SPI1	ChEA Transcription Factor Targets	1.0	null
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.746
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-2826-SM-4B65I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893419
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8424594-main.nxml--DUB_ZUP1	Rummagene Transcription Factor Associations 2026	1.0	null
ME-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.275
isoproterenol hydrochloride_rattus norvegicus_gpl1355_gse7999	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
PMC9574515-mmc1.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2720-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SUSD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50538
GTEX-PWOO-0826-SM-48TCL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04312
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A82E-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ND-39-PO34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.326421
Lung adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.222
premotor cortex (area 6)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.46999
CHD2	ENCODE Transcription Factor Targets	1.0	null
deNEDDylase activity	GO Molecular Function Annotations 2025	1.0	null
GSE98964_1_v_4_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COLO-800	GDSC Cell Line Gene Expression Profiles	-1.0	-1.6115
LYAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09985
PPP2R2D	Pathway Commons Protein-Protein Interactions	1.0	null
CA-72-JV60_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212464
fallopiantube_8d	HPA Tissue Sample Gene Expression Profiles	1.0	2.09964
uterine cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.485156
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65105
AB-21-VE32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.336422
AC-28-RT00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262197
PMC7804490__F2	PFOCR Pathway Figure Associations 2024	1.0	null
dna repair	GO Biological Process Annotations 2015	1.0	null
GSE248769_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.606
GSE172295_1_v_2_sh3gl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCF7_PCI-34051_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153046
GSE128730_0_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF607	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63114
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ubiquitination	GeneRIF Biological Term Annotations	1.0	null
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66418
BRD-K87593103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40742
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06129
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary auditory cortex (core)_25 pcw_F_12948	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.27817
KU1919	CCLE Cell Line Gene Expression Profiles	1.0	1.41792
TP53-23651856-MEF-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.946072
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MERO14	DepMap CRISPR Gene Dependency	1.0	2.66458
ESR1	Pathway Commons Protein-Protein Interactions	1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
GTEX-WRHU-2826-SM-3MJG8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879931
Perturb_3138_KO_Med1_SRP078070	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.60618
BL2194 (USP4)	NURSA Protein Complexes	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GA-88-CF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.491074
BRD-K12011077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78311
Clathrin vesicle coat	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.124
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.62746
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-QQ-A8VH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.427177
PMC7098486-mmc2.xlsx-Kgg_Quant_NGN2_AAVS_-_WCL-Unnamed_2_NEUROG2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879358
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE231648_0_v_5_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.861151
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Proteasome regulatory particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.649
iopamidol-7189	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC3493483-ppat.1003002.s009.pdf-23-NR2F2_NR2F2	Rummagene Transcription Factor Associations 2026	1.0	null
3054_FECH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.519045
Machado-Joseph disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.456
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Large B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58633
egg	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.707631
ATF3	ENCODE Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13121
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.797
Urinary bladder cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.389
TSC22D1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-ENSEMBL_TBX4	Rummagene Transcription Factor Associations 2026	1.0	null
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
YWHAZ	Pathway Commons Protein-Protein Interactions	1.0	null
A549_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206338
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
5964_LTO1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.571781
ZNF143	ENCODE Transcription Factor Targets	1.0	null
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.996637
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCIH522	DepMap CRISPR Gene Dependency	1.0	2.67451
BRD-K83697352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04893
BRD-K37596331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71096
ABCC8	Hub Proteins Protein-Protein Interactions	1.0	null
fallopiantube_8e	HPA Tissue Sample Gene Expression Profiles	1.0	0.889328
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.561
A549_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142787
Cortical collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
GSE246195,GSE246305_4_v_3_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
a-ABIN1 (TNIP1)	NURSA Protein Complexes	1.0	null
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06166879	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65027
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KLM1	CCLE Cell Line Gene Expression Profiles	1.0	2.18328
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.510848
MUTZ5	CCLE Cell Line Gene Expression Profiles	-1.0	-2.32615
BRD-K76263570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60359
BB-93-VT73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.416309
POLR2A	ENCODE Transcription Factor Targets	1.0	null
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.4651
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
how	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7065-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
estradiol_mus musculus_gpl4134_gse23241	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OHPN-0011-R4A-SM-2I5FD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12054
negative regulation of organelle organization	GO Biological Process Annotations 2015	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
496100407_FWM_probable Alzheimer's disease_no TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.56689
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A5PC-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cerebellar ataxia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.087
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10495
SNU410	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53689
GSE109140_2_v_3_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24558
Mobilized_CD34_Primary_Cells_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.3643
PMC4905335__F1	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43793
decreased exploration in new environment	MGI Mouse Phenotype Associations 2023	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.856783
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.6337
hsa-miR-4313	TargetScan Predicted Conserved microRNA Targets	1.0	0.219115
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.877119
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.756
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.600339
signalling	GeneRIF Biological Term Annotations	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46543
GTEX-SNMC-0126-SM-2XCFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00206
PIERCE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08588
P31-FUJ	COSMIC Cell Line Gene Mutation Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.38566
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SHSY5Y	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99623
GTEX-TSE9-3026-SM-3DB76	GTEx Tissue Sample Gene Expression Profiles	1.0	2.3019
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31297909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12923
EJM	CCLE Cell Line Gene CNV Profiles	1.0	1.54826
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.42321
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12759
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.922244
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17716
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96277
KRT18	Pathway Commons Protein-Protein Interactions	1.0	null