association	dataset	threshold value	standardized value
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67308
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18918
RUNX1	ChEA Transcription Factor Targets	1.0	null
Parotid acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.232
hsa-miR-637	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Parasitic protozoa infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
granule	GeneRIF Biological Term Annotations	1.0	null
Area postrema	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.629
BRD-K01995700	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56154
GTEX-XYKS-2626-SM-4BRUT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67307
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
TPM4	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-Q2AH-2026-SM-2S1PX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22584
RFX5	ENCODE Transcription Factor Targets	1.0	null
intermediate stratum of r2Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03964
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CFAP418	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62099
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3767
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X8-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60799989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25949
GTEX-X62O-1626-SM-46MW9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54208
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
bounding membrane of organelle	GO Cellular Component Annotations 2025	1.0	null
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
Blood platelet	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SNX21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8629
nucleotide	GeneRIF Biological Term Annotations	1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QK-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K42873980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0523
CIR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32206
BRD-K05786443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44977
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975669
DETROIT562	DepMap CRISPR Gene Dependency	1.0	2.18075
Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-7085-01A-21R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-361-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K90858591	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76436
regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6647-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.60862
positive regulation of hydrolase activity	GO Biological Process Annotations 2015	1.0	null
TCF3/E2A-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
IL18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601663
monocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.132155
CEP68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78549
AIM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99072
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
membrane	LOCATE Curated Protein Localization Annotations	1.0	null
medulla oblongata	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.424581
FOXO3_01_267	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.39031
Autoimmune disease of central nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.858
Lung adenocarcinoma_LUAD_TCGA-55-8092-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K26383086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71009
K562_Iniparib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0349468
GTEX-UTHO-0011-R4A-SM-3GIJP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37733
pancreatic ductal adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.16468
hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050739
pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060035
regulation of muscle system process	GO Biological Process Annotations 2015	1.0	null
ZNF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12538
GSE231339_1_v_0_itgav_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE238018_1_v_4_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Vandetanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020744
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.5409
NDUFC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00469637
protein-kinase-c	Phosphosite Textmining Biological Term Annotations	1.0	null
GTEX-W5WG-1026-SM-4LMIF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860438
K562_Resveratrol_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169356
MFE-319	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K69984954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19933
ncce	GeneRIF Biological Term Annotations	1.0	null
BRD-K92749855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1226
BRD-K66013406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02189
lad2	GeneRIF Biological Term Annotations	1.0	null
GTEX-X88G-0426-SM-47JZ5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838353
Urinary tract infection	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
TM31	CCLE Cell Line Gene CNV Profiles	1.0	1.56243
Liver Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02222
K562_Trametinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0454123
Lung-basophil	Tabula Sapiens Gene-Cell Associations	1.0	0.473377
GSE224970,GSE224971_1_v_0_sap30_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMC3-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
pontine nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.959665
trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.207084
MSH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49656
CALB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42463
ZCCHC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47826
COBL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7293
hsa-miR-501-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
caudal division of IPC (area 39)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27253
contractile	GeneRIF Biological Term Annotations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A3JJ-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Platelet calcium homeostasis	Reactome Pathways 2024	1.0	null
EOMES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.64335
K562_Roscovitine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0400288
GTEX-R55C-0008-SM-48FCF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915874
K562_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.026978
blood plasma	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Heart	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052835
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1493
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_48_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
neuron-neuron synaptic transmission	GO Biological Process Annotations 2015	1.0	null
G61	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.50484
Peripheral ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.05
K562_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0303944
OUMS23	CCLE Cell Line Gene CNV Profiles	-1.0	-2.44105
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A6UG-01A-32R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K07982814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27399
nasal cavity	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.180226
CREB1-26743006-CHIP-SEQ-LNCAP-ABL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
K562_Lapatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180366
MHHCALL3	CCLE Cell Line Gene Expression Profiles	1.0	2.11966
Malignant exocrine pancreas neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
GTEX-S95S-0008-SM-4AT5M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13974
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928438
selective	GeneRIF Biological Term Annotations	1.0	null
GTEX-RU72-1226-SM-2TF6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57377
somatoform disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.335412
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K92981306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40783
Thrombosis	DisGeNET Gene-Phenotype Associations	1.0	null
functioning	GeneRIF Biological Term Annotations	1.0	null
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80718
RIMS1	Pathway Commons Protein-Protein Interactions	1.0	null
ovary cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059043
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0065
dorsolateral prefrontal cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.975963
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Heat_LPStoThermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-4594-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endotoxemia	DisGeNET Gene-Phenotype Associations	1.0	null
regulation of presynaptic cytosolic calcium levels	SynGO Synaptic Gene Annotations	1.0	null
FBXL20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00632507
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34952
K562_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0430499
BRD-K30038014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.56724
Mitochondrial inner membrane peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.916
Perturb_15184_KD_SREBP_SRP190161	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Rectum adenocarcinoma_READ_TCGA-F5-6810-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VSNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2851
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.32002
BRD-K40826084	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25104
NELFE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72539
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.875098
produced	GeneRIF Biological Term Annotations	1.0	null
bladder	GeneRIF Biological Term Annotations	1.0	null
thyroid	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.23983
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
induces	GeneRIF Biological Term Annotations	1.0	null
TNFRSF12A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19199
r2 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.9843
direct	GeneRIF Biological Term Annotations	1.0	null
organelle envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
channels	GeneRIF Biological Term Annotations	1.0	null
BRD-K82433264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49547
BRD-K75887263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3632
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
proteinaceous extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.380045
Neurotransmitter receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.589
RASGRF1	Pathway Commons Protein-Protein Interactions	1.0	null
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO Biological Process Annotations 2015	1.0	null
MT-ND1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45382
Perturb_13502_KD_WDR5_SRP321449	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-8.21699
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MO-1926-SM-32QOJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18518
POLDIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71959
physiologic	GeneRIF Biological Term Annotations	1.0	null
BRD-K29469525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40941
ACTN3	Pathway Commons Protein-Protein Interactions	1.0	null
Ventral posterolateral nucleus of the thalamus, parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49336
GTEX-T2IS-0011-R3A-SM-32QPB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843241
Urinary bladder smooth muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
collagen trimer	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.354802
GLB1L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94682
GSE174498,GSE174500_0_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K72464155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07463
K562_CEP-33779_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175032
intrinsic component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.139244
Lung adenocarcinoma_LUAD_TCGA-91-8496-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_UNC1999_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0309717
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DCAF16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75728
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909886
pulp	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.391553
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19982
Nerve plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.925
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE185519_3_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
intrinsic component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.126631
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
brain	HPA Tissue Gene Expression Profiles	-1.0	-0.993631
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
Bone remodeling disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.276
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.989025
BRD-K27915221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14883
NFKBIL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8751
external encapsulating structure part	GO Cellular Component Annotations 2015	1.0	null
paraventricular nucleus, peduncular or principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39391
lateral hemisphere of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34151
fetus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
NAGLU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24471
Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
integral component of organelle membrane	GO Cellular Component Annotations 2015	1.0	null
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.833148
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC16A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15572
FGFR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521121
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14616
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965874
NEO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07556
HOXA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83823
Depression	DisGeNET Gene-Disease Associations	1.0	null
BRD-K61595867	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.331
CTCF	MotifMap Predicted Transcription Factor Targets	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.214714
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
sphingolipid metabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6799
PMC10528072-NIHMS1928302-supplement-5.xlsx-NEUROD1-target_genes-AANAT_NEUROD1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K53544328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97097
SKIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44809
Huntington's Disease_Blood_GSE1751	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.33454
avian pallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.10473
BRD-K97588749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01715
p2x2	GeneRIF Biological Term Annotations	1.0	null
BRD-K67522096	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00647
GTEX-PW2O-0826-SM-48TC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04574
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7424-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1	Rummagene Transcription Factor Associations 2026	1.0	null
SEC24B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76127
OCIAML2	CCLE Cell Line Gene Expression Profiles	1.0	2.49943
15474998-tableS1a	GeneSigDB Published Gene Signatures	1.0	null
Intestinal disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.779
dense	GeneRIF Biological Term Annotations	1.0	null
Chronic Pain	DisGeNET Gene-Phenotype Associations	1.0	null
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MN-01A-22R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHWD-2426-SM-3LK6S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49381
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07176
macromolecular complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Cystic Fibrosis	DisGeNET Gene-Disease Associations	1.0	null
GSE154767_4_v_3_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.382354
thyroid_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.05403
IZ in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.04448
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.309697
CBX3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TEX10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18246
FAM110C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00903
Bipolar Disorder	DisGeNET Gene-Disease Associations	1.0	null
PMC11167905-10194_2024_1805_MOESM1_ESM.xlsx-S6-Table_S6_MR_results_of_brain_eQTLs_and_migraine_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
corpus cavernosum clitoridis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.638809
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZDHHC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08648
regulation of peptidase activity	GO Biological Process Annotations 2015	1.0	null
Autonomic nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
biological regulation	GO Biological Process Annotations 2015	1.0	null
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.967238
GTEX-UJHI-0008-SM-4IHL1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19475
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-BrtoFay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6496-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25665
19429869-TableS1	GeneSigDB Published Gene Signatures	1.0	null
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.933182
PMC9288051-13046_2022_2428_MOESM5_ESM.xlsx-Super_enhancers_in_T-ALL3-CLOSEST_GENE_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
SULT1C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.02975
hsa-miR-4500	TargetScan Predicted Conserved microRNA Targets	1.0	0.131849
peripheral nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.925479
SAMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51969
amygdaloid complex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.894508
PMC13082837-NIHMS2159075-supplement-3.xlsx-DataTable5_Methylation_LMS-UCSC_RefGene_Name_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF177	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35904
female pudendum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.181847
BCL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49407
DYRK1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67181
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7394-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K32191695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09124
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.4757
K562_KW-2449_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195278
Platelet activation	KEGG Pathways 2026	1.0	null
K562_Aminoglutethimide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195818
plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.590133
BRD-K71243741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44516
positive regulation of peptidase activity	GO Biological Process Annotations 2015	1.0	null
ZBTB48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83607
K562_Fulvestrant_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0263756
inner SZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.864278
Membrane raft	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
PKP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46936
GSE180200,GSE180201_15_v_1_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
longitudinal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.12438
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
placenta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.096379
Colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.6
GTEX-XUW1-0726-SM-4BOP5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51102
muscular coat	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.926336
BRD-K48519079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04555
Bone cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.204
Blood platelet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.31
RAPGEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77738
IFNLR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61181
BTBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7711
Renal medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.845
controlled	GeneRIF Biological Term Annotations	1.0	null
mantle zone of r2Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04394
KCNIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.27456
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857243
Autonomic nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.789
ZNF436	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14298
Traumatic brain injury	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.529
p2x1mediated	GeneRIF Biological Term Annotations	1.0	null
adrenal medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.301398
skeletalmuscle_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.07549
GSE71100_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Tanycyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.72
Perisynaptic space	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.791
TAL1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889671
paraventricular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.94974
SETDB1	ENCODE Transcription Factor Targets	1.0	null
limb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063186
PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP	Rummagene Transcription Factor Associations 2026	1.0	null
SJSA-1	GDSC Cell Line Gene Expression Profiles	1.0	1.56491
SNAP25	Pathway Commons Protein-Protein Interactions	1.0	null
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.278
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K01225247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0244
K562_Maraviroc_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179846
Mitochondrial inner membrane assembly complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.638
response to atp	GO Biological Process Annotations 2015	1.0	null
hematopoietic stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.154855
seminal vesicle	HPA Tissue Protein Expression Profiles	1.0	1.61878
UBF1/2-26484160-CHIP-SEQ-HMEC-DERIVED-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-2690-01A-02R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74040368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77272
adp	GeneRIF Biological Term Annotations	1.0	null
GSE131887_5_v_3_doxycycline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SLC3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98643
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.00223
KYSE-270	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RBM15_02_171	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60438
BRD-K60123410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10181
K562_Belinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185723
SA1-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ACOT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52265
K562_Maraviroc_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235387
presynaptic	GeneRIF Biological Term Annotations	1.0	null
Hemostasis	Reactome Pathways 2014	1.0	null
PGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25147
LC4-1	GDSC Cell Line Gene Expression Profiles	1.0	1.8432
Bladder-smooth muscle cell	Tabula Sapiens Gene-Cell Associations	1.0	0.366883
ASB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63199
PF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86345
PPP3CA	Pathway Commons Protein-Protein Interactions	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.505
GSE166004_3_v_6_pld1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HCFC1	ENCODE Transcription Factor Targets	1.0	null
CRCGN008_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4806
hsa-miR-3128	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K97106314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4093
GTEX-W5X1-0008-SM-4LMKA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
BRD-K19066553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13422
GSE131649_2_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
15-delta prostaglandin J2-2691	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC12660214-Supplementaryfile1.xlsx-Genes_Human_with_ATF3-binding-regulation_of_membrane_potential_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
adrenal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.119128
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_24hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
kinasedependent	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7097-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPK-0008-SM-4E3JL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85072
GSE140322_3_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU886	CCLE Cell Line Gene Expression Profiles	-1.0	-2.35373
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Medial preoptic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.74778
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.912
RASA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.33124
PIEZO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40453
Integrin alpha2-beta1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.424
extracellular	GeneRIF Biological Term Annotations	1.0	null
adenosine	GeneRIF Biological Term Annotations	1.0	null
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
leg	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072279
Li	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.756
LY-294002-401	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K31678817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17403
CHN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40991
MOLM13	CCLE Cell Line Gene Expression Profiles	1.0	1.79348
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.857954
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944064
SOCS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38532
BRD-K34519313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06192
Hoof	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
GATA1_megakaryocyte_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF263	ENCODE Transcription Factor Targets	1.0	null
Cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Adrenal gland cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.576
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30902
Vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
synapse part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.460401
HL60	BioGPS Cell Line Gene Expression Profiles	1.0	1.53844
anterior pretectal nucleus, ventral superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13763
Odontoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.695
U-138MG cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.581
GTEX-WFG8-0008-SM-4LVN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3144
ITGB5	Pathway Commons Protein-Protein Interactions	1.0	null
GSE234340_4_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Anterior spinothalamic tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-HEB_CCRFCEM_ChIP-seq_TCF12	Rummagene Transcription Factor Associations 2026	1.0	null
GPRIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70503
GTEX-OHPK-1826-SM-2YUMR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991029
Psoriasis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
KNS81	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53863
Bed nucleus of the accessory olfactory tract	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3853
TMEM131	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17539
K562_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0275919
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.871329
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18259
GSE81193_1_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
specific granule membrane	GO Cellular Component Annotations 2023	1.0	null
Pituicyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.858
GSE216043_7_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal male genitalia morphology	MPO Gene-Phenotype Associations	1.0	null
BRD-K75007044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44166
GOLGA6L9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26668
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
Oocyst	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.708
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.932473
p2y	GeneRIF Biological Term Annotations	1.0	null
K562_CUDC-101_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166405
GTEX-R45C-0008-SM-48FF2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34537
uroepithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.659897
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-11A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_33_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
K562_Obatoclax Mesylate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0459272
BRD-K15393664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.29907
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SG-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adenyl nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07794
sense organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.618603
p2x1receptor	GeneRIF Biological Term Annotations	1.0	null
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.870342
enhancing	GeneRIF Biological Term Annotations	1.0	null
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70044
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.945656
Lupus Erythematosus	DisGeNET Gene-Disease Associations	1.0	null
TNNI3	Pathway Commons Protein-Protein Interactions	1.0	null
GSE180200,GSE180201_2_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
monoatomic ion transport	GO Biological Process Annotations 2025	1.0	null
BRD-K52850071_JAK3 Inhibitor II_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE226091,GSE226092_3_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TNNT2	Pathway Commons Protein-Protein Interactions	1.0	null
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
cell outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GSE202434,GSE202438_13_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TMEM63B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6275
BRD-K03339354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49732
PRDM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70192
RAP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95518
serotonin transport	GO Biological Process Annotations 2015	1.0	null
K562_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0252366
GSE199606_3_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-53-7813-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Blood platelet disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
Lung adenocarcinoma_LUAD_TCGA-44-2661-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-564	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
K562_2-Methoxyestradiol_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0449759
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML3-OVERLAP_GENES_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
pancreatic duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.135034
GSE172247,GSE172250_0_v_2_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
molecular transducer activity	GO Molecular Function Annotations 2015	1.0	null
CHP134	DepMap CRISPR Gene Dependency	1.0	4.51781
larger	GeneRIF Biological Term Annotations	1.0	null
Hyperuricemia	DisGeNET Gene-Disease Associations	1.0	null
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03733288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79629
XBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52227
MYOD1	ENCODE Transcription Factor Targets	1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880804
olfactory epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.386273
MICALL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2718
hsa-miR-3620	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
GSE234340_12_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Specific granule membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Lung adenocarcinoma_LUAD_TCGA-64-5779-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRDM5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51693
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
principal	GeneRIF Biological Term Annotations	1.0	null
FAM53B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98029
THAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30878
CTCF_bone marrow_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
200d	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.994
PMC9941047-41591_2022_2163_MOESM3_ESM.xlsx-ST12-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
CCNY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02165
depends	GeneRIF Biological Term Annotations	1.0	null
Perturb_17439_KO_Uqcrfs1_SRP279621	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.48838
BHLHE40_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4875_OE_HAND1_SRP216437	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Brain infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065
K562_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0264094
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
decreased litter size	MPO Gene-Phenotype Associations	1.0	null
496100374_HIP_possible Alzheimer's disease_TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.51403
clitoris	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.191382
mgatp2	GeneRIF Biological Term Annotations	1.0	null
ARFGAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1525
501A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931233
Nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.525
GSE148692,GSE148695_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Entinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0203001
abnormal cardiovascular system physiology	MPO Gene-Phenotype Associations	1.0	null
GSE190534,GSE190536_0_v_3_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
action potential	GO Biological Process Annotations 2015	1.0	null
hsa-let-7e	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
GTEX-TMZS-0008-SM-47JWM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52146
EPLC272H	CCLE Cell Line Gene CNV Profiles	1.0	1.39759
does	GeneRIF Biological Term Annotations	1.0	null
Vascular smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.795
Nephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.046
intrinsic component of nuclear inner membrane	GO Cellular Component Annotations 2015	1.0	null
PMC9942321-12916_2023_2766_MOESM1_ESM.xlsx-S9-Supplementary_Table_9_DEGs_distributed_per_SOM_profile_in_all_IS_etiologies_based_on_Euclidean_distance_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
ALL-PO	GDSC Cell Line Gene Expression Profiles	1.0	1.77238
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950603
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.545
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31010207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60798
GSE89018_11_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
positive regulation of proteolysis	GO Biological Process Annotations 2015	1.0	null
placenta	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.224913
Iris sphincter muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.785
FLI1	ENCODE Transcription Factor Targets	1.0	null
BRD-K16852474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20001
cyclophosphamide_mus musculus_gpl13209_gds4004	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nuclear envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
sensory	GeneRIF Biological Term Annotations	1.0	null
aging	GeneRIF Biological Term Annotations	1.0	null
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.96
BRD-K46588240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49624
GSE180200,GSE180201_3_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CiliaryGanglion	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.971338
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04739
PMC11665843-SYB2-18-218-s001.pdf-164-PBX1_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44799944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8322
periventricular stratum of r7Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32748
dorsomedial preoptic area, intermediate part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06841
IPO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72023
CRCGN009_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.56172
RASSF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01859
DYNC2I1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55305
endotoxemia	GeneRIF Biological Term Annotations	1.0	null
GATA2	JASPAR Predicted Transcription Factor Targets	1.0	null
K562_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0308842
MDAMB453	CCLE Cell Line Gene CNV Profiles	-1.0	-1.82985
K562_BMS-265246_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236767
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.901147
hsa-miR-3130-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Chronic Obstructive Airway Disease	DisGeNET Gene-Disease Associations	1.0	null
Cerebellar granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.119
KCNMB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53731
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A1A1-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
APOBEC3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37142
response to organonitrogen compound	GO Biological Process Annotations 2015	1.0	null
K562_Cediranib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267603
K562_Ramelteon_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156036
TOLLIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.19026
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55G-0008-SM-48FEX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26755
ERF::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.3709
ATG2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97498
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_42_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
MIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76034
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-NB4-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_NB4_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
nucleotide receptor activity	GO Molecular Function Annotations 2015	1.0	null
SOX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5679
SIN3A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell body	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.241356
NCI-H2804	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03014
primary visual cortex (striate cortex, area V1/17)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.30902
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QLQ7-0008-SM-447AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3423
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TFEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5687
NCBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08643
K562_KW-2449_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164009
BRD-K27476515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99915
skeletal	GeneRIF Biological Term Annotations	1.0	null
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.937834
YD8	CCLE Cell Line Gene CNV Profiles	1.0	1.37241
TNNT3	Pathway Commons Protein-Protein Interactions	1.0	null
HDAC3_KO_GDS4886_29_mouse_heart - 6 week old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
DLD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63467
Bronchial smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.906
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K06500446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.50331
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.60207
SHH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52199
GTEX-XLM4-0426-SM-4AT54	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63037
Lymphoid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.032
NDUFA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16033
ectodomain	GeneRIF Biological Term Annotations	1.0	null
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
postsynaptic membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
alone	GeneRIF Biological Term Annotations	1.0	null
primary auditory cortex (core)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.57668
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4769-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_PF-3845_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.02512
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.49852
GATA1	ENCODE Transcription Factor Targets	1.0	null
regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE166004_5_v_4_pld1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MOLP8	CCLE Cell Line Gene CNV Profiles	1.0	1.52919
medullary collecting duct cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.592444
abnormal male germ cell morphology	MPO Gene-Phenotype Associations	1.0	null
K562_Costunolide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199249
Extrinsic asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
19192944-TableS4	GeneSigDB Published Gene Signatures	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04243
Myeloid Leukemia	DisGeNET Gene-Disease Associations	1.0	null
Influenza	DisGeNET Gene-Disease Associations	1.0	null
pancreatic cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068594
receptors	GeneRIF Biological Term Annotations	1.0	null
Muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-RUSQ-1926-SM-2TF6K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976104
MRS 2219	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
SGO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80324
SNU398	CCLE Cell Line Gene Expression Profiles	-1.0	-1.45597
BRD-K74399971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49613
ZNF425	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99428
GTEX-X4XY-0008-SM-46MVL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47448
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Retrosplenial area, lateral agranular part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12112
RNH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77208
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
ERF::SREBF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2702
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834792
Rectum adenocarcinoma_READ_TCGA-AG-3731-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_3_SED-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
IFFO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65541
PLXNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55735
K562_BMS-536924_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0306836
AK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.956
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864745
K562_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0128441
IQGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53631
PARD6G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07619
lymphoid cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056856
PRM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91129
suramin	GeneRIF Biological Term Annotations	1.0	null
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02373
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
dorsolateral part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78094
cerebellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.449886
sp13	GeneRIF Biological Term Annotations	1.0	null
bone marrow	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.799
DNTTIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70118
GTEX-XOT4-0426-SM-4B66T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55906
GTEX-RVPV-0226-SM-2TF6W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87866
alexidine-4721	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ophthalmic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.606
KYO1	DepMap CRISPR Gene Dependency	1.0	5.3384
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_human_DRSG_higherRes-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Periventricular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44756
salivarygland	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.63861
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE226408_1_v_0_inpp4b_human	RummaGEO Gene Perturbation Signatures	1.0	null
lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
K562_SRT3025 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.027074
CGTHW1	CCLE Cell Line Gene CNV Profiles	1.0	1.39024
GSE140092_0_v_1_socs3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VAMP2	Pathway Commons Protein-Protein Interactions	1.0	null
GSE173873_2_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BV-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.172
lateral (dentate) cerebellar nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.7636
Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A6GD-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FGFR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1536
cell-cell signaling	GO Biological Process Annotations 2015	1.0	null
pyramidal layer of IG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84602
INA6	DepMap CRISPR Gene Dependency	1.0	7.29978
Medulla	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.43105
Spinal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.545
GSE126219_0_v_1_haloperidol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CARMIL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05381
IWS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87039
TEAD4	ENCODE Transcription Factor Targets	1.0	null
GLIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4577
K562_A-366_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0262379
BRD-K55916310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07523
GNAO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49127
SERPINB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98646
WIDR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12469
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHD2	ENCODE Transcription Factor Targets	1.0	null
Hemostasis	Reactome Pathways 2024	1.0	null
megakaryoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.548517
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TPBGL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26607
BRD-A69097282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58438
BRD-K51181201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32474
specific granule	GO Cellular Component Annotations 2025	1.0	null
S462	DepMap CRISPR Gene Dependency	1.0	2.25967
protein processing	GO Biological Process Annotations 2015	1.0	null
BRD-K63829331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05792
SULT4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11833
production	GeneRIF Biological Term Annotations	1.0	null
GTEX-UPIC-0726-SM-3GADW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95919
junctional membrane complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.222436
JOSD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00043
K562_Hesperadin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0339902
BRD-K48813201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19956
PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K71881549	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10385
GSE210911_1_v_0_crem_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nucleus solitarius	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.939
GSE224294_4_v_2_ngly1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.125
ZNG1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78622
channel activity	GO Molecular Function Annotations 2015	1.0	null
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Uterus-myometrial cell	Tabula Sapiens Gene-Cell Associations	1.0	0.153896
GSE245270_2_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K03304013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29965
hl-60 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.295297
Depressed Mood	DisGeNET Gene-Phenotype Associations	1.0	null
Parastrial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08793
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S6-Table_S6_The_result_of_MR_analysis_and_sensitivity_analysis_for_DLco_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
SEMA4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34241
BRD-K93534327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11925
BRD-K36460068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06755
Lamina propria	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.293
Osteoporosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.291
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-6_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_PHA-680632_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0347206
CRCGN016_MCF10A.TP53.M_24H:F06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0225
K562_Aurora A Inhibitor I_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191597
iPS-20b Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.985853
BRD-K27331198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27653
BRD-K87872414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35232
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11409
GSE146074_10_v_7_ly6e_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mesoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.08673
GSE218060_2_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
response to purine-containing compound	GO Biological Process Annotations 2015	1.0	null
GTEX-T2IS-1026-SM-32QP1	GTEx Tissue Sample Gene Expression Profiles	1.0	2.43201
GSE65617_2_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83877
Adrenocortical carcinoma_ACC_TCGA-OR-A5L9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
L-βγ-meATP	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
K562_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0180537
GTEX-NFK9-0326-SM-3MJGV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37838
other	GeneRIF Biological Term Annotations	1.0	null
18818702-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FAM72B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71919
p2y2	GeneRIF Biological Term Annotations	1.0	null
Chronic obstructive pulmonary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.299
Aorta thoracica	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.811
hsa-miR-502-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
layer 1 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51761
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_SRT3025 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.029319
19755993-Table4	GeneSigDB Published Gene Signatures	1.0	null
NDRG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53593
purinergic nucleotide receptor activity	GO Molecular Function Annotations 2025	1.0	null
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
extracellular region part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.331342
rafts	GeneRIF Biological Term Annotations	1.0	null
CINP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22656
Bladder-pericyte cell	Tabula Sapiens Gene-Cell Associations	1.0	0.595084
GSE127916_1_v_4_nras_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE120595_5_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FGF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45021
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03098
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.278955
GSE176305_0_v_3_rotenone_human	RummaGEO Drug Perturbation Signatures	1.0	null
accessory entopeduncular nucleus (post-migratory)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78806
plant reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.126336
K562_SRT3025 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0356205
SLC25A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03983
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.012
Hippocampus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
lipid	GeneRIF Biological Term Annotations	1.0	null
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC3419980-leu201249x6.xls-RUNX1-DHS-1000bp-Unnamed_0_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE228727_2_v_1_dapagliflozin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Pelitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0282487
ZNF780A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01381
H4C15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66766
urinary bladder	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.837613
CD276	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89985
Myelencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.226
alpha,beta-methyleneadenosine 5'-triphosphate	CTD Gene-Chemical Interactions	1.0	null
BRD-K14442101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74217
BRD-K14706855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60703
LOXL2_KD_GSE35600_688_human_MDA-MB-231 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE124471,GSE124488_2_v_3_lats1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.11
HPRT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07963
ceramide metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
KLK10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77914
GSE152441,GSE152442_7_v_2_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Exocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.178
K562_Panobinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0263618
IGFBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3357
IZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08222
only	GeneRIF Biological Term Annotations	1.0	null
Vagus nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.535
adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055331
Nr1h3::Rxra	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	40.4279
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5100-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5701-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POC1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51569
Perturb_6428_KD_ADAR1_SRP009659	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
BRD-K62707745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34989
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975968
Supraoptic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.113
basal nucleus of Meynert	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0649
plasma membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BRD-K74755318	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17942
K562_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0257024
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.75323
K562_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0348615
blast cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
17823238-TableS5	GeneSigDB Published Gene Signatures	1.0	null
Perturb_4308_KO_FOXM1_SRP328179	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
carbohydrate metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.264077
multi-organism reproductive process	GO Biological Process Annotations 2015	1.0	null
outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
ventral entopeduncular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0712
MERO25	DepMap CRISPR Gene Dependency	1.0	3.62074
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8546
GTEX-QDVN-0008-SM-48U2D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
cell communication	GO Biological Process Annotations 2015	1.0	null
BRD-A56345662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80504
K562_Disulfiram_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195831
SYNGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90164
chronic myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.104673
contractions	GeneRIF Biological Term Annotations	1.0	null
BRD-K40630587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6933
BRD-K98667932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03312
mast cells	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.07371
MADD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20274
Autosomal dominant nonsyndromic deafness 41	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.572
second (ventral) preoptic domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78885
transporter activity	GO Molecular Function Annotations 2015	1.0	null
connective tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.255234
Inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.138
LMTK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.55859
GSE137177_2_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.040376
PMC3435504-msb201237-s2.xls-Supp_Table_4b-REST_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GSE89018_12_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10701
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-1026-SM-33HB7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71509
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_6_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.834
binding	GO Molecular Function Annotations 2015	1.0	null
HIF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74489
GTEX-QEG5-0626-SM-2S1PP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854589
Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7128-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22221
KLKB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21075
FLNC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71467
regulation of catalytic activity	GO Biological Process Annotations 2015	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of cysteine-type endopeptidase activity	GO Biological Process Annotations 2015	1.0	null
22RV1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.512171
GSE131649_4_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-common-common_genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_NB4_HL-60_and_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RWSA-0526-SM-2XCBC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75122
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IB-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SE5C-1026-SM-4BRUG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64028
Glomus cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.771
migraine	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.37592
BRD-K22510845	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09719
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55G-0426-SM-48FDH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07544
sphingolipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975835
Astrocyte end-foot	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.114
BRD-K09434518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.76115
NEUROG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18125
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.940675
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.1487
RRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63911
bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043341
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.21568
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VV-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mifepristone-3185	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ott1_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.088031
K562_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0494955
NDUFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0536
K562_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0329092
PMC8127234-12885_2021_8319_MOESM2_ESM.docx-0-CREB3L1_CREB3L1	Rummagene Transcription Factor Associations 2026	1.0	null
Habenula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.905
K562_Raltitrexed_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0512637
K562_Motesanib Diphosphate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0401137
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.22461
GTEX-XMK1-2526-SM-4B666	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84568
integral component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MRPS17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84426
revealed	GeneRIF Biological Term Annotations	1.0	null
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
K562_PCI-34051_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0303227
GTEX-R55E-0008-SM-48FCG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78328
vasculature	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.33744
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16162
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14137
HELA	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.97012
ZNF354C	JASPAR Predicted Transcription Factor Targets	1.0	null
PMC12549544-mmc2.xlsx-AA_D1_VS_D7-Name_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
MYC_KD_GSE22139_685_human_medulloblastoma	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Anterodorsal preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.42485
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.168
K562_PF-3845_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243947
LARGE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83741
Primary somatosensory area, barrel field, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.44531
BRD-K66580188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16921
GSE165939_2_v_1_poldip2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE163052,GSE163198_6_v_3_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
INPP5D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0050265
DAXX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41067
GSE131649_6_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
serotonin secretion by platelet	GO Biological Process Annotations 2015	1.0	null
Artery wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.367
BRD-K23164928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24804
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16662
BRD-K76984291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02506
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U8XE-0126-SM-4E3I3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.885662
GSE169697,GSE169725_0_v_4_prrx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
smooth	GeneRIF Biological Term Annotations	1.0	null
blood coagulation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.081426
abnormal internal male genitalia morphology	MPO Gene-Phenotype Associations	1.0	null
GTEX-W5WG-2226-SM-4LMI3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73731
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A4EO-06A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Extracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.555
MDFIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45583
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.1812
SETDB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09833
GTEX-TML8-0008-SM-4DXUI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07184
K562_Tranylcypromine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.030874
DES	Pathway Commons Protein-Protein Interactions	1.0	null
vascular process in circulatory system	GO Biological Process Annotations 2015	1.0	null
RAB5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.48927
LXFL529	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.684
BRD-K72792753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05398
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.935987
Secretory vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.59789
r2 part of superior vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03964
Skin	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.02066
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07193
GTEX-O5YW-0326-SM-2I5EI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912032
monovalent inorganic cation transport	GO Biological Process Annotations 2015	1.0	null
PRDM14-20953172-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XLM4-0008-SM-4AT4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90853
GSE110178_2_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864543
SMRT-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
divalent inorganic cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Submandibular gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
effective	GeneRIF Biological Term Annotations	1.0	null
mainolfactoryepithelium.MOE.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.915831
contribute	GeneRIF Biological Term Annotations	1.0	null
GTEX-OXRK-0526-SM-3NB2F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26388
QDPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49538
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10528
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_14530_KO_Nr5a2_SRP111204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-13.3463
Connective tissue cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.078
eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.328994
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2338
Tachyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.172
Prostate adenocarcinoma_PRAD_TCGA-G9-6351-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAD21	ChEA Transcription Factor Targets	1.0	null
renal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.227445
Iris	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.516
RUNX1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RPE1SS51	DepMap CRISPR Gene Dependency	1.0	2.61935
first	GeneRIF Biological Term Annotations	1.0	null
GATA1_G1E-ER4_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
systemic	GeneRIF Biological Term Annotations	1.0	null
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88617
BRD-K32918816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42382
r3 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31483
BRD-A38030642_cyclosporin A_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
atpinduced	GeneRIF Biological Term Annotations	1.0	null
urinarybladder_5b	HPA Tissue Sample Gene Expression Profiles	1.0	2.15665
GRIN2D	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K46924722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62773
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4900-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K41731186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86367
GTEX-WL46-0526-SM-3LK7W	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02802
LNCAP	BioGPS Cell Line Gene Expression Profiles	1.0	0.923308
musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.054991
lateral part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50316
K562_Tanespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0298641
Perturb_14532_KO_Ptf1a/Nr5a2_SRP111204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
Nucleus of the lateral olfactory tract, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12171
ring	GeneRIF Biological Term Annotations	1.0	null
PML	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47101
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
PROM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26903
BL41	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33414
varicosities	GeneRIF Biological Term Annotations	1.0	null
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
CLOCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94765
RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
bladder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.46784
K562_CUDC-101_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0287909
tetrandrine-6082	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.319328
vascular smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.442194
axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.500258
K562_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0590701
PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-MV4-11_MLL-AF4_target_genes_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201309_1_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
deep layers of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.917135
positive regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K87213231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23534
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35862
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
KIAA0319L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87175
hek-293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.646505
BRD-K48533326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12021
PMC11637729-BJH-205-2450-s001.docx-0-GATA2_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
inorganic anion transport	GO Biological Process Annotations 2015	1.0	null
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of transport	GO Biological Process Annotations 2015	1.0	null
DEPDC1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56813
PRMT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05195
thioridazine-417	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V1-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Andarine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168926
tonus	GeneRIF Biological Term Annotations	1.0	null
Neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.422
GSE132408_0_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PPP1R2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.663
BRD-K60918542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1645
secretory granule membrane	GO Cellular Component Annotations 2025	1.0	null
ECGI10	CCLE Cell Line Gene CNV Profiles	1.0	2.07909
BCL6-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
azoospermia	MPO Gene-Phenotype Associations	1.0	null
LMSU	CCLE Cell Line Gene CNV Profiles	1.0	1.79822
BRD-K74116035	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.93264
ZNF614	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23718
GTPBP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21053
CDK5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96296
posteroventral (inferior) parietal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11653
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.179
BRD-K87034416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04725
GSE131649_6_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
XPOT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86531
JHUEM3	CCLE Cell Line Gene Expression Profiles	-1.0	-2.35234
Corticotropic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.533
K562_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0322854
Primary somatosensory area, barrel field, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.58524
intracellular non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.052051
Alveolar cell type I	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.507
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6017-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
p2x3	GeneRIF Biological Term Annotations	1.0	null
BRD-K67426191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05785
increased systemic arterial blood pressure	MPO Gene-Phenotype Associations	1.0	null
ME-180	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RPL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39062
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_15_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE110178_1_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X585-0008-SM-46MU4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908878
GTEX-Q2AG-0526-SM-2S1PW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44931
PMC7824059__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GSE233679_12_v_4_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4723-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COPG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69726
elements	GeneRIF Biological Term Annotations	1.0	null
BRD-K54250149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43514
METTL21C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65522
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
K562_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0283308
STRN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87622
BRD-K43431234	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21776
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.165
BRD-K51163606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09334
K562_Sodium Phenylbutyrate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0369815
FIS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.95123
TFAP2A	ENCODE Transcription Factor Targets	1.0	null
positive regulation of catalytic activity	GO Biological Process Annotations 2015	1.0	null
p2x	GeneRIF Biological Term Annotations	1.0	null
RMI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2905
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.177
Lung squamous cell carcinoma_LUSC_TCGA-56-7222-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3975	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
protein complex	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
GSE104508_2_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SG in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	3.34018
GSE195559_6_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
support	GeneRIF Biological Term Annotations	1.0	null
Glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.355
IKZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.2761
PMC3435504-msb201237-s2.xls-Supp_Table_4c-REST_REST	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0270023
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.343042
superficial stratum of r9BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44661
YPEL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95307
GSE228894_3_v_2_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFIX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77601
K562_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01964
BRD-K34573818	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02643
PROKR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1888
atrophic muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.190168
ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.344818
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.4591
plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE172020_0_v_2_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
GTEX-QEG4-1226-SM-2S1P6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60482
nephron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.366754
BRD-K99727034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19114
CD14+_Monocytes	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.24163
BICR 78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60799
BRD-K68985225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37492
BRD-K09711841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.07679
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_78_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
EPS8L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55221
Astroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.181
Prostate adenocarcinoma_PRAD_TCGA-G9-6384-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Urinary bladder epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
K562_SRT2104_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232724
BRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92459
thrombosis	GeneRIF Biological Term Annotations	1.0	null
FASTKD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52118
LY-294002-424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
urinary bladder	HPA Tissue Gene Expression Profiles	1.0	1.19794
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bronchopulmonary Dysplasia	DisGeNET Gene-Disease Associations	1.0	null
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846772
OC316	DepMap CRISPR Gene Dependency	1.0	2.15372
GTEX-XUYS-0426-SM-47JX3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17741
lys68	GeneRIF Biological Term Annotations	1.0	null
H3K36me3_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09191
P2RY12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0056707
GSE109530,GSE109531_1_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular	GeneRIF Biological Term Annotations	1.0	null
GTEX-OOBJ-1826-SM-3NB1C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838374
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.90768
brain ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.228497
Submucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.346
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GCSAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43574
CALD1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K52190624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04557
CLK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08584
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.355
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864387
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LEMD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08439
neuroactive ligand receptor interaction	KEGG Pathways	1.0	null
hemorrhagic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.112628
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.46915
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SEC24D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74631
olfactory organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.227445
Hepatitis, Autoimmune_Hepatic Tissue_GSE867	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.77752
ligand-gated calcium channel activity	GO Molecular Function Annotations 2025	1.0	null
GSE235234_2_v_3_corticosterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WEY5-0008-SM-4LMKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58899
external iliac artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.431843
BRD-K55612106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36012
abnormal vas deferens morphology	MGI Mouse Phenotype Associations 2023	1.0	null
fluorouracil_homo sapiens_gpl550_gds848	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_ENMD-2076_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0122814
Glycoprotein Ib-IX-V complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.539
VKORC1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24792
rbm15_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.088031
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RU72-0008-SM-46MV8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35328
BRD-K01850737	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03138
hemostasis	GeneRIF Biological Term Annotations	1.0	null
DNMBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55665
vascular smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.818994
BRD-K31330911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37408
marrow cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-T2IS-0011-R5A-SM-32QP4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72437
BRD-K71138333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4213
changes	GeneRIF Biological Term Annotations	1.0	null
macroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.29673
HCC1171	CCLE Cell Line Gene Expression Profiles	-1.0	-1.86374
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.7893
DPYSL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61494
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K38748890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04798
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_downregulated_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
abnormal systemic arterial blood pressure	MPO Gene-Phenotype Associations	1.0	null
GTEX-S3XE-0008-SM-3NM8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37116
BRD-K84239940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23104
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15772
PCI-4B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
peak	GeneRIF Biological Term Annotations	1.0	null
Overactive Bladder Syndrome	DisGeNET Gene-Disease Associations	1.0	null
SNU349	CCLE Cell Line Gene Expression Profiles	-1.0	-1.75349
GTEX-X4XY-0526-SM-46MW1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42185
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50829
K562_FLLL32_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0192886
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23314
K562_Alisertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0391241
GSE152432_5_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
F11R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0751
MOLP8	CCLE Cell Line Gene Expression Profiles	1.0	1.47788
organelle part	GO Cellular Component Annotations 2015	1.0	null
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
regulation of blood circulation	GO Biological Process Annotations 2015	1.0	null
GSE164874_5_v_6_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_5_v_4_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
macromolecular complex	GO Cellular Component Annotations 2015	1.0	null
trypsin	Phosphosite Textmining Biological Term Annotations	1.0	null
Perturb_3583_KO_DNMT3A_SRP312248	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
RPL19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07444
PLPBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89867
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9728
SMC3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
19303107-Table2	GeneSigDB Published Gene Signatures	1.0	null
r1 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31483
BRD-K28953184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58959
BRD-K95651150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05219
Hematopoietic stem cell_Bone marrow_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
synaptic membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
LZTR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77038
BRD-K54861624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.42889
K562_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0230966
K562_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0338532
GSE244072_10_v_1_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12084
husk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.250627
BRD-K52657580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2602
some	GeneRIF Biological Term Annotations	1.0	null
DLX5_KO_GSE22381_5_mouse_ear (otic vesicle)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BGN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82234
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898931
substantia nigra, compact part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.866711
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891091
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
BRD-K44344720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20651
reducing	GeneRIF Biological Term Annotations	1.0	null
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19627
GSE128844_0_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
rhombomere 6	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22039
PBX3	ENCODE Transcription Factor Targets	1.0	null
MAZ_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Flavopiridol HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182353
KRAS.600_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
sensitivity	GeneRIF Biological Term Annotations	1.0	null
ZER1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41512
AP3D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65996
K562_Nilotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023518
DLX5_Deficiency_GDS4443_355_mouse_E10 embryos	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A624-01A-22R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pheneticillin-6105	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Organism form	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
arteriole	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.908814
GSE151090_2_v_4_verteporfin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
Sarcoplasmic reticulum	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.237
RARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41922
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.291
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-7_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ECI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69768
hsa-miR-3131	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
interactions	GeneRIF Biological Term Annotations	1.0	null
GTEX-XUZC-2026-SM-4BRW9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29986
BRD-K33940145	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1787
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.17891
astrocytoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.375743
neutrophil	GeneRIF Biological Term Annotations	1.0	null
K562_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0264752
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
microglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.630718
GSE195559_6_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
Syncytium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.13
A4GALT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55816
PLCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36402
Brain Lower Grade Glioma_LGG_TCGA-S9-A7R2-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K93486796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.36849
GSE182680,GSE182683_10_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
wide	GeneRIF Biological Term Annotations	1.0	null
pod	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.405935
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851421
GFI1B-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SNOS-1726-SM-32PLN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29878
cinchocaine-1969	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
regulation of cell death	GO Biological Process Annotations 2015	1.0	null
MYL12B	Pathway Commons Protein-Protein Interactions	1.0	null
GSE110178_2_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
shell of SCH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06526
bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.44636
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.102
GSE164874_5_v_7_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K45642123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15798
vestibular labyrinth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.387027
RORA_1	MotifMap Predicted Transcription Factor Targets	1.0	null
intermediate stratum of r9Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.28685
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900608
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YN-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Temsirolimus_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0243245
K562_Alvespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0306499
GSE202434,GSE202438_12_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5497057-ncomms15921-s2.xlsx-AA_PCa_vs_AA_NP-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
Masseter	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.785
RALGDS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.29013
regulation of body fluid levels	GO Biological Process Annotations 2015	1.0	null
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pacemaker cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.982
USP20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89891
metal ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
hsa-miR-644	TargetScan Predicted Conserved microRNA Targets	1.0	0.766596
Reticular nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24196
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
Quebec platelet disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.001
regulation of blood vessel size	GO Biological Process Annotations 2015	1.0	null
WDR45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49866
K562_Aminoglutethimide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0192108
U118	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.987434
Glomerulonephritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-g-Classification_of_camel_SON_basal_genes_-_ion_channels_SON	Rummagene Transcription Factor Associations 2026	1.0	null
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Polymorphonuclear leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.931
SW1783	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Parasympathetic nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.518
pathways	GeneRIF Biological Term Annotations	1.0	null
Cauda epididymis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.761
PMC8321895-41375_2020_779_MOESM4_ESM.xlsx-marker_genes-LMO2-LYL1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.330589
hsa-miR-4728-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
cytoskeletal part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.043743
GSE131649_2_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.066
detrusor	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.67506
Dorsal claustrum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00491
cross-linking	Phosphosite Textmining Biological Term Annotations	1.0	null
PPP3CB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49104
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.02929
PARD6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02729
Sarcoma_SARC_TCGA-X6-A8C5-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K37722313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03333
BRD-K40206099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27035
PMC9334849-Table_3.xlsx-subcutaneous_adipose_tissue-D1_VS_D9_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849402
SCAF11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29522
NALM16	DepMap CRISPR Gene Dependency	1.0	9.14463
Dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
GATA1_G1E-ER4_mm9_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73606
macromolecular complex subunit organization	GO Biological Process Annotations 2015	1.0	null
TCF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98237
cortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.999248
GTEX-QMRM-0008-SM-447B1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29286
glia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.794792
mediodorsal nucleus of thalamus_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1547
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FO-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
layer 1 of PrS	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33126
protein heterooligomerization	GO Biological Process Annotations 2015	1.0	null
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Apicolateral plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.685
BRD-K38907993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29951
BHLHE40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.28463
DUSP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28092
Primary visual area, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19057
lateral ventricle	HPA Tissue Protein Expression Profiles	-1.0	-1.81209
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAL1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4UY-0426-SM-3K2AF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08399
K562_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0278553
BRD-K31300534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05592
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.6022
BRD-K35451051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08021
periventricular part of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83417
BRD-K59445060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24158
GSE169152_5_v_7_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
antiinflammatory	GeneRIF Biological Term Annotations	1.0	null
TRMT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.93359
caudal zona incerta	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20957
17875932-TableS4	GeneSigDB Published Gene Signatures	1.0	null
periventricular stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.07105
GSE114992,GSE114993_7_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Thiotepa_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0198121
496100507_FWM_dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.22348
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01018
Forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Contractile vacuole complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.359
CRCGN011_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81095
Neuroactive ligand signaling	KEGG Pathways 2026	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-1005-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
platelets	GeneRIF Biological Term Annotations	1.0	null
BRD-K13514097_S1120_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
vomeronasal organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.217554
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.914
GATA1_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DB	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
subsequent	GeneRIF Biological Term Annotations	1.0	null
g8	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
CHD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4483
Osteoarthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.054
GTEX-XQ3S-0008-SM-4GIDZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85466
RAB1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60581
BRD-K85284710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02095
Dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.259
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-10_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
OGDHL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.757
Perturb_17213_OE_EWSFLI_SRP261076	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.59727
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.868
GSE160817_5_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE118794_5_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
COLO 857	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34419
2-iodomelatonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.46458
PMC11461876-42003_2024_6975_MOESM3_ESM.xlsx-Supplementary_Data_1-Supplementary_Data_1_Differentially_Expressed_Genes_HSE_THP1_Vs_THP1_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
Temporal lobe epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.382
PPFIA3	Pathway Commons Protein-Protein Interactions	1.0	null
purinergic receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15343
reticular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.853396
primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.52546
BRD-K71414336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09257
Obstructive lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.295
AMIGO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45537
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.98371
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4983
K562_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252674
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_9_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
MAP3K7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12685
Lung squamous cell carcinoma_LUSC_TCGA-77-8008-11A-01R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16413
MZ in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.63132
ATP-gated ion channel activity	GO Molecular Function Annotations 2025	1.0	null
PMC5993681-mmc4.xlsx-Tabelle1-Metacore_analysis_of_SRF_binding_targets_SRF	Rummagene Transcription Factor Associations 2026	1.0	null
P300-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.984387
ZNF445	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.15565
GSE111247_0_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
OC315	CCLE Cell Line Gene Expression Profiles	-1.0	-1.6352
ELK4-26923725-CHIP-SEQ-MESODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.73
occur	GeneRIF Biological Term Annotations	1.0	null
cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.458404
K562_Crizotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0246538
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4QT-1826-SM-2S1NJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850441
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.911
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.914173
K562_TAK-901_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153774
LYSMD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07034
Ionotropic glutamate receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.315
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07944
BRD-K01250897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02135
Fusiform vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.816
bone marrow	HPA Tissue Protein Expression Profiles	1.0	1.61878
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12568
GTEX-XAJ8-1226-SM-47JYS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24945
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8083-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-3665	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5559-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Ivosidenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0424213
Contact dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.112
single organism signaling	GO Biological Process Annotations 2015	1.0	null
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
Vas deferens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.311
GTEX-XUYS-0008-SM-47JYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19961
K562_MLN8054_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.034762
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.6263
K562_Zileuton_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0314456
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Ofloxacin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0391651
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ITGA1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873836
BRD-K76114475	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54753
GTEX-RN64-0008-SM-48FEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KRAS.600.LUNG.BREAST_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
adult stem cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE242333_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
RXRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	71.4153
Neuroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.339
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.573
Malignant Head And Neck Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
ALLSIL	CCLE Cell Line Gene CNV Profiles	-1.0	-1.429
leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070289
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.2992
Pancreatic adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
K562_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0349439
utilized	GeneRIF Biological Term Annotations	1.0	null
CPNE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46492
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Diarrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
NPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30704
THUMPD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60769
Bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.679
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29236
extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.373899
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.87476
neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043379
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_54_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
NOXO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89008
GTEX-VUSG-2826-SM-4KKZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04888
LMO2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S341-2026-SM-2XCAA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28808
K562_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139526
Sinus node	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.596
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K12460566	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49862
PRR11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22388
MAPKAPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.61766
bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.01554
Glanzmann's thrombasthenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.09
intrinsic component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
GTEX-QMR6-0008-SM-447AV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62894
Arterial smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.142
H3K4me1_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
pituitary	GTEx Tissue Gene Expression Profiles	-1.0	-1.03557
GSE199034_1_v_0_pirfenidone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
atpgated	GeneRIF Biological Term Annotations	1.0	null
saphenous vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220831
TMEM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64483
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
SYNCRIP_KD_GDS3578_86_human_MM1S	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
K562_Sirtinol_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0682748
K562_Flavopiridol HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0385347
PYGB	Pathway Commons Protein-Protein Interactions	1.0	null
actomyosinmediated	GeneRIF Biological Term Annotations	1.0	null
Borderline Personality Disorder	DisGeNET Gene-Disease Associations	1.0	null
GSE216043_11_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Mocetinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0300699
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961908
varicosity	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.791022
BRD-K27754030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19003
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.08634
FAM124A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82174
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6SW-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
19074878-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
cytoplasmic vesicle membrane	GO Cellular Component Annotations 2023	1.0	null
TRIO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88726
regulation of vascular smooth muscle contraction	GO Biological Process Annotations 2015	1.0	null
GSE163052,GSE163198_2_v_7_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Chemoreceptor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.878
pyrazinamide_mus musculus_gpl6246_gse48027	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
astrocytoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.5228
Cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
ligand-gated monoatomic cation channel activity	GO Molecular Function Annotations 2025	1.0	null
canrenoic acid-6783	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
18537972-TableS4	GeneSigDB Published Gene Signatures	1.0	null
p2x4	GeneRIF Biological Term Annotations	1.0	null
ERBIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67811
K562_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168557
PBRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65203
ANKRD34B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36296
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.58414
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22839
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04638
K562_Danusertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.030235
r10 part of spinal trigeminal nucleus, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09869
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
H2BC15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07314
USP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73945
STARD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63437
Thrombocytopenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
K562_Barasertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0243653
MECOM-23826213-KASUMI-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Depression	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K90793170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19952
NCIH1836	DepMap CRISPR Gene Dependency	1.0	2.68552
HNRNPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36338
PMC7824059__F4	PFOCR Pathway Figure Associations 2024	1.0	null
umbilicalcord	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	2.09859
SSTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42923
BRD-K45367466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6129
OVMANA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53774
BRD-K30917841	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28307
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
positive regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10422
BRD-K66623602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11882
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.69385
MRPS36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25453
SETDB1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PLB-985 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.547
absent gametes	MPO Gene-Phenotype Associations	1.0	null
HDAC2	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X3-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2979-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAPT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0051408
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Mercaptopurine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.014644
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_24_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.683
BRD-K97183783	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01766
SP in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10299
Inflammatory bowel disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.813
macrophages	GeneRIF Biological Term Annotations	1.0	null
ZBTB47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02154
midline nuclear complex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.30246
UFSP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6208
inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.882691
SMC4-20622854-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-UJHI-1326-SM-4IHJO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20632
presence	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.298524
RCOR1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
there	GeneRIF Biological Term Annotations	1.0	null
SKIC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.79275
FBXL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84608
BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42122
Lung squamous cell carcinoma_LUSC_TCGA-39-5040-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K47410882	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87891
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.766
SP1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Respiratory allergy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.298
PPP3CB	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-4470	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
Lung adenocarcinoma_LUAD_TCGA-55-6985-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
distribution	GeneRIF Biological Term Annotations	1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.126
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.72359
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.32017
metal ion transport	GO Biological Process Annotations 2015	1.0	null
HCC193	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.857954
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4457
BRD-K86964464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52528
Purinergic signaling	WikiPathways Pathways 2024	1.0	null
connecting stalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.126765
AATF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51002
MYL4	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JH-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RGS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.77238
BRD-K04714488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49458
monoatomic cation transmembrane transport	GO Biological Process Annotations 2025	1.0	null
p2x14	GeneRIF Biological Term Annotations	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.023
PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GATA1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
epithelioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051362
intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.61866
cerebellar cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.534251
either	GeneRIF Biological Term Annotations	1.0	null
BRD-K06994380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34327
GSE145639_7_v_6_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
organic substance transport	GO Biological Process Annotations 2015	1.0	null
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.964
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
K562_Andarine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0214855
GTEX-P4QR-0726-SM-2I5GO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846547
HTC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.774
Lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.082
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28938
TUR	GDSC Cell Line Gene Expression Profiles	1.0	1.90122
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.503
DNAJC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20519
GTEx Brain 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	1.0	13.1681
MYL3	Pathway Commons Protein-Protein Interactions	1.0	null
trichostatin A-1400	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ERA-21632823-H3396-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
K562_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0289938
Perturb_962_KD_UHRF1_SRP331230	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Iris smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.65
GTEX-U3ZH-1726-SM-3DB79	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58784
Ureter	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.439
K562_Motesanib Diphosphate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0292811
Gfi1b_OE_GDS4302_425_mouse_AMuLV (pro-B Abelson leukemia virus transformed) cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983448
Corneal Allograft Rejection	DisGeNET Gene-Disease Associations	1.0	null
Bipolar disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.399
Neuralgia	DisGeNET Gene-Phenotype Associations	1.0	null
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26659
Pancreatic duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.21
lysines	GeneRIF Biological Term Annotations	1.0	null
mantle zone of r8BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02976
HOXB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5376
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5818_KO_Gata2_SRP239807	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.33839
GTEX-OIZI-0008-SM-2XCFD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.90109
MEWO	CCLE Cell Line Gene CNV Profiles	1.0	1.42704
BRD-K71514806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.6005
hsa-miR-4443	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GTEX-QDT8-0008-SM-48U2F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21677
LTBR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00680647
Primary somatosensory area, nose	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20915
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.875329
HMBOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25883
synapse part	GO Cellular Component Annotations 2015	1.0	null
GSE85565_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-A56U-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
combination	GeneRIF Biological Term Annotations	1.0	null
GTEX-V1D1-2226-SM-3NMAX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845124
BRD-K34741587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59897
BRD-K04701596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42865
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00526
GSE137818_5_v_1_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K64474460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4729
ZZEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0377
K562_JQ1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156734
Autoimmune disease of musculoskeletal system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.679
GTEX-XBEC-0008-SM-4AT3X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864163
BRD-K72314068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78172
blood plasma	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07176
BRD-K75806288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20912
regulation of vasoconstriction	GO Biological Process Annotations 2015	1.0	null
STAT2_02_18	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60493
GSE174498,GSE174500_3_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.155323
ENGASE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46454
GSE111247_11_v_9_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
r9 part of the lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14094
TMOD1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K26140483	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14939
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0223086
Interstitial cystitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.213
synaptic transmission, glutamatergic	GO Biological Process Annotations 2015	1.0	null
K562_Nintedanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234797
Lung squamous cell carcinoma_LUSC_TCGA-85-7710-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Impaired Cognition	DisGeNET Gene-Disease Associations	1.0	null
GSE202434,GSE202438_12_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
gut wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.190172
BRD-K88974575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01846
olfactory bulb, principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00515
ZNF594	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3464
PMC5768349__F4	PFOCR Pathway Figure Associations 2023	1.0	null
NR3C1-34362910-WISTARRAT-HIPPOCAMPUS-STRESS	ChEA Transcription Factor Targets 2022	1.0	null
muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.085205
PMC4243378-13059_2014_494_MOESM1_ESM.xlsx-S1_6_Gene_sets_CIITA_BIs-B_cells_CIITA_not_RFX5_RFX5	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF730	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0564
cellular lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
VCL	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.39425
GSE179036_1_v_0_trim24_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PREPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44561
Neuroactive ligand-receptor interaction	KEGG Pathways 2026	1.0	null
BRD-K98758203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68832
lymphoid tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.221291
GTEX-OIZH-1826-SM-2YUNP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921598
brain_3c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.843321
Paragigantocellular reticular nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.47849
superficial stratum of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36788
TCFL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68842
PMC10809641-DataSheet3.pdf-289-OTX2-AS1_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFON-2526-SM-3LK7P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69846
BRD-K41310621	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39386
RELA	JASPAR Predicted Transcription Factor Targets	1.0	null
ZSWIM9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05762
Blood clot	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.812
GSE156708_1_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166308_1_v_0_pim1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KCTD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50772
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
OTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.12773
neural	GeneRIF Biological Term Annotations	1.0	null
Median preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.3771
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04004
Lung squamous cell carcinoma_LUSC_TCGA-56-8201-11A-01R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167542
NDST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05848
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.603
BRD-K70412800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85147
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861146
GTEX-T2IS-0926-SM-4DM5B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924929
r9 part of spinal vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.29042
RHO	Pathway Commons Protein-Protein Interactions	1.0	null
SURF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62805
mediodorsal nucleus of thalamus_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12783
SLC25A24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65729
Medullary collecting duct cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.592
capsaicin-4612	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCIH1755	CCLE Cell Line Gene CNV Profiles	-1.0	-2.1337
Primary lysosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.658
agranular insular cortex (area Iag)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19642
ATP-gated ion channel activity	GO Molecular Function Annotations 2023	1.0	null
Supplemental somatosensory area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.42073
dorsal septopreoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.51617
BRD-K39348592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20004
postsynaptic membrane	GO Cellular Component Annotations 2015	1.0	null
GSE147662_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE229978_4_v_1_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
macromolecular complex assembly	GO Biological Process Annotations 2015	1.0	null
apomorphine-2005	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
splitomicin-661	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	70.7189
GTEX-TSE9-2226-SM-4DXUR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29816
GSE140651,GSE140653_2_v_7_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Calcitonin family receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.741
captopril-1988	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
mediodorsal nucleus of thalamus_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11907
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20674
K562_Crizotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0340514
localization	GO Biological Process Annotations 2015	1.0	null
CXCR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.75403
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RAB31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74313
membrane raft	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
MDAMB468	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.985135
Pulmonary Arterial Hypertension	DisGeNET Gene-Disease Associations	1.0	null
Perturb_4384_KD_PC4_SRP340634	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-7.64521
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.779
GTEX-Q2AH-0008-SM-48U2J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34582
superficial stratum of the IG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84681
GTEX-RU72-0226-SM-46MUD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864092
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SF1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K02073410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04261
BRD-K49704392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06415
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_72_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
TRPT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00584475
GSE169152_3_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A65806553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.51373
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.03603
WFS1_KO_GSE33372_395_mouse_hypothalamus	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
K562_Alisertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0430792
brain cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.495701
megakaryocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.553683
BRD-K17582293	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58145
Ion channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.936
pancreatic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067066
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
GTEX-SSA3-0426-SM-32QPI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968987
K562_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0241343
response to organic cyclic compound	GO Biological Process Annotations 2015	1.0	null
leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075005
AVPR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00728993
HG3	DepMap CRISPR Gene Dependency	1.0	5.19097
IP6K2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76955
cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
IKBKB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24152
GTEX-S7SE-0526-SM-2XCD8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.30698
GSE121319_1_v_0_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
r10 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.17779
modiolus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297806
WDR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12395
BRD-K13696195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11799
induction	GeneRIF Biological Term Annotations	1.0	null
rostral (anterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.09689
mapping	GeneRIF Biological Term Annotations	1.0	null
CAMK2D	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K89837874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3091
amplitude	GeneRIF Biological Term Annotations	1.0	null
differences	GeneRIF Biological Term Annotations	1.0	null
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Declive (VI)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06679
hsa-miR-4459	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
RAB3A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K38969544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04914
blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.955134
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-VJWN-0626-SM-3NMAN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998346
Cranial ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.832
FHIP1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46976
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
promotes	GeneRIF Biological Term Annotations	1.0	null
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE115363_2_v_4_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Oligodendroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.695
PCMTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66235
ETS1-22383799-G1ME-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TCERG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98092
periventricular stratum of PPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39391
ZFHX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53867
Perturb_12524_KD_Linc00673_SRP212104	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE163052,GSE163198_6_v_7_hira_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	-1.0	null
component	GeneRIF Biological Term Annotations	1.0	null
ALKBH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.60795
Astrocytoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.431
CUX1-19635798-MULTIPLE HUMAN CANCER CELL TYPES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
FAH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12717
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876561
HCC366	DepMap CRISPR Gene Dependency	1.0	2.72327
KLM1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66836
K562_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0250395
confirmed	GeneRIF Biological Term Annotations	1.0	null
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12485
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964683
Amyotrophic Lateral Sclerosis	DisGeNET Gene-Disease Associations	1.0	null
ZCCHC24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35978
stresstriggered	GeneRIF Biological Term Annotations	1.0	null
MYC-19829295-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Uropod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.595
PMAIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90098
bone marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.133025
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09742
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01636
membrane raft	GO Cellular Component Annotations 2025	1.0	null
HNF4	MotifMap Predicted Transcription Factor Targets	1.0	null
BPTF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14764
hsa-miR-1324	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
Lung	GTEx Tissue Gene Expression Profiles 2023	1.0	2.08713
BRD-K71778797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76028
morphological	GeneRIF Biological Term Annotations	1.0	null
KRBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24491
cation transport	GO Biological Process Annotations 2015	1.0	null
bone marrow cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
K562_Ki8751_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0328726
PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RFX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00413605
PMC7445411-CPR-53-e12862-s006.xlsx-Sheet1-Supplementary_Table_S4_Gene_expression_profiling_of_NT-MSC_and_III-MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K19161227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70737
Rectum adenocarcinoma_READ_TCGA-DT-5265-01A-21R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
degranulation	GeneRIF Biological Term Annotations	1.0	null
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Spi1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	46.8086
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-A76A-01A-51R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K40862705	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8811
FLI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9132
K562_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259271
Arteriole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.921
BRD-K54099984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36649
PPP3R1	Pathway Commons Protein-Protein Interactions	1.0	null
discs	GeneRIF Biological Term Annotations	1.0	null
BRD-K87537204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15983
Parasubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18948
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AP-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA1-19941827-MEL86-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE133516_5_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TNNC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85115
PKIG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90051
regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
reoxygenation	GeneRIF Biological Term Annotations	1.0	null
PLPPR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02208
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76326
CUX1-19635798-MULTIPLE-CANCER-TYPES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
extensive	GeneRIF Biological Term Annotations	1.0	null
DHX40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22128
K562_Givinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0255202
GSE112761,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-AR-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hemostasis	GO Biological Process Annotations 2015	1.0	null
Synaptic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.595
C1orf122	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91202
Autoimmune disease of the nervous system	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.849
Parasubthalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15276
CADM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59539
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
NF023	DGIdb Drug Targets 2026	1.0	4.812
Muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	52.0218
site	GeneRIF Biological Term Annotations	1.0	null
BRD-K04546108_JAK3 Inhibitor VI_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Urinary bladder smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.409
plasma membrane	LOCATE Curated Protein Localization Annotations	1.0	null
reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.261599
Tracheal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.834
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.84918
SNU119	CCLE Cell Line Gene Expression Profiles	-1.0	-1.79239
K562_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259718
interact	GeneRIF Biological Term Annotations	1.0	null
MRPS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12958
SMIM26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26325
Lung adenocarcinoma_LUAD_TCGA-55-6968-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5358-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4823830-ncomms11171-s4.xlsx-high_in_shRNA_TCF1-GeneSymbol_HNF1A	Rummagene Transcription Factor Associations 2026	1.0	null
MPZL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.388
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
receptor activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-XQ8I-0126-SM-4BOPL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.953497
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.859
myelencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.421148
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.63399
posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.48
PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
alimentary canal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.304279
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826081
MAX	JASPAR Predicted Transcription Factor Targets	1.0	null
TT2609C02	DepMap CRISPR Gene Dependency	1.0	4.81223
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Chronic asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.314
imatinib_homo sapiens_gpl96_gds3042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UTP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25922
LTN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19775
NTMT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.83647
other source	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.413912
K562_SRT1720 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0180406
GSE140322_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K13091682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.37135
hypothalamus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.27999
Musculoskeletal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.062
flow	GeneRIF Biological Term Annotations	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6227-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADENOSINE TRIPHOSPHATE	DGIdb Drug Targets 2026	1.0	0.283059
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131649_6_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T5JC-1526-SM-4DM68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03674
coexpression	GeneRIF Biological Term Annotations	1.0	null
oocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.2461
SP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.70961
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.418
Tear gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.881
BRD-K86143816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05508
ATP6V1E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07875
OTT1_KO_GDS4315_146_mouse_HSC	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
hsa-miR-576-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DEDD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68933
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FGFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03947
Lung adenocarcinoma_LUAD_TCGA-86-6851-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Mercaptopurine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216883
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02281
exist	GeneRIF Biological Term Annotations	1.0	null
establishment of localization	GO Biological Process Annotations 2015	1.0	null
parotid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.169796
GALNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89371
striatal septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32469
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.84406
GTEX-S95S-1626-SM-2XCDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20423
blood platelet	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.47241
ETS1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF451	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63515
GM2493	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.30966
protein complex subunit organization	GO Biological Process Annotations 2015	1.0	null
GSE68156_0_v_5_dextran_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95837
thioproperazine-1390	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974141
foot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.108935
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTNNAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45041
endomembrane system	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Acute Myeloid Leukemia_LAML_TCGA-AB-2848-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Tucidinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133951
Outer hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.857
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
signal transducer activity	GO Molecular Function Annotations 2015	1.0	null
A-CA-04-2009(H1N1)_24Hour_None_GSE40844	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.31099
BRD-K77490065	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46957
BRD-K83095019	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12839
BRD-K56427898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14229
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04004
Cells - EBV-transformed lymphocytes	GTEx Tissue Gene Expression Profiles 2023	1.0	6.40876
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
K562_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191689
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
par4pretreated	GeneRIF Biological Term Annotations	1.0	null
carboxy	GeneRIF Biological Term Annotations	1.0	null
Postsubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.02705
KMS34	CCLE Cell Line Gene Expression Profiles	1.0	1.52021
K562_Roscovitine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0217273
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0917
substitution	GeneRIF Biological Term Annotations	1.0	null
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.936761
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.152
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
JAK2_knockdown_192_GSE54645	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.64716
Vascular smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.623
16151515-TableS4	GeneSigDB Published Gene Signatures	1.0	null
Toxic encephalopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
PMC9288051-13046_2022_2428_MOESM6_ESM.xlsx-Super_enhancers_in_B-ALL1-CLOSEST_GENE_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NOL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.9248
Spinothalamic tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
GSE160817_5_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sensitive lamina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.756
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KM-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inhibitors	GeneRIF Biological Term Annotations	1.0	null
transcription	GeneRIF Biological Term Annotations	1.0	null
smooth muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.81209
BRD-K65626032	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49756
Lung Neoplasms	HuGE Navigator Gene-Phenotype Associations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A4ZT-11A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TOB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11769
DUX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5201
exocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.108955
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JE-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r9 part of the inferior olive	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.76118
ZDHHC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74068
BRD-K25426017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26689
BRD-K73166462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00617
mainly	GeneRIF Biological Term Annotations	1.0	null
LOXL2_DEPLETION_GDS4884_88_human_MDA-MB-231 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE137177_1_v_0_folic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131649_6_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0328549
LSR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.39569
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
plasma membrane region	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.100948
r8 part of gigantocellular reticular area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06823
ICAM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30406
NOMO-1	GDSC Cell Line Gene Expression Profiles	1.0	1.46539
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.67521
GTEX-T6MN-0426-SM-32PMF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74981
white matter of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04668
external male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.2259
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
multi-multicellular organism process	GO Biological Process Annotations 2015	1.0	null
PRSS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34002
serine	GeneRIF Biological Term Annotations	1.0	null
glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.798958
BRD-K12836153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24131
H3K4me1_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hindbrain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26427
cortical amygdaloid nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.534251
ADIPOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44085
substance-related disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
Hyperactive Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
neuron part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.563432
NCOR1	ENCODE Transcription Factor Targets	1.0	null
protein complex assembly	GO Biological Process Annotations 2015	1.0	null
PARP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03587
ANKRD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.46259
PMC11993713-41598_2025_96655_MOESM1_ESM.xlsx-S10-Table_S10_MR_results_of_the_discovery_blood_cis-eQTLs_and_Sepsis_outcomes_in_IVW_or_Wald_ratio_methods_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
protective	GeneRIF Biological Term Annotations	1.0	null
NG-108-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.503
CRLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8717
Pain disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.81
SNU886	DepMap CRISPR Gene Dependency	1.0	3.65308
GTEX-S4Z8-0008-SM-33HAZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
positive regulation of programmed cell death	GO Biological Process Annotations 2015	1.0	null
hsa-miR-650	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
Urinary bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.047
PPM1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89321
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825137
striatum_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.883807
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.513
IDH3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12572
BRD-K27823380	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11337
BRD-K31121304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47185
Temporomandibular joint	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.018
CBX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00168
Cranial nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.955
Paraventricular hypothalamic nucleus, magnocellular division, medial magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49783
phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.11286
Primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.197
WWP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89614
PFEIFFER	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45801
cerebellum	HPA Tissue Protein Expression Profiles	-1.0	-1.81209
NR3C1	JASPAR Predicted Transcription Factor Targets	1.0	null
Innate Immune System	Reactome Pathways 2024	1.0	null
MONOMAC1	CCLE Cell Line Gene Expression Profiles	1.0	1.89974
PMC5390115-mmc3.xlsx-DE_Lists_Exp_2-H1-EC2_3-fold_TCF15	Rummagene Transcription Factor Associations 2026	1.0	null
PIGW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83176
EW22	DepMap CRISPR Gene Dependency	1.0	2.38274
Nkx2-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.4504
MYH3	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Raltitrexed_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0353091
GSE125403_7_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Carcinogenesis	DisGeNET Gene-Phenotype Associations	1.0	null
nitrogen compound transport	GO Biological Process Annotations 2015	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
superficial stratum of PcPV	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13763
GTEX-U8T8-0326-SM-3DB93	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63435
Gut wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.296
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15335
CRB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29215
RS4-11	GDSC Cell Line Gene Expression Profiles	1.0	1.9551
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05808
TPM1	Pathway Commons Protein-Protein Interactions	1.0	null
COX4I1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99012
chronic myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.108545
Urinary bladder	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE101239_3_v_0_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.665166
Distal axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.876
superficial stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06565
NEK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43562
P12-ICHIKAWA	GDSC Cell Line Gene Expression Profiles	1.0	1.78703
GSE145445,GSE145454_0_v_1_cop1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EP300_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70017
OVCA 432	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72345
ACTN2	Pathway Commons Protein-Protein Interactions	1.0	null
basal part of cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.242076
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	1.0	null
than	GeneRIF Biological Term Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6969-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06431647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51963
Corpus cavernosum penis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.668
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orphenadrine-2356	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Parasitic infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.412
Urinary Bladder, Underactive	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K01817716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12264
K562_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196204
system process	GO Biological Process Annotations 2015	1.0	null
GSE233679_12_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE223008_9_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
fiber	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.451813
P2X1 purinoceptor	InterPro Predicted Protein Domain Annotations	1.0	null
SYTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16502
Fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.67
MAGED4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00234
MYOG_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34895
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
agonist	GeneRIF Biological Term Annotations	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_2_TBRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
synapse	GeneRIF Biological Term Annotations	1.0	null
GATA1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
MEG-01 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.58
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K05462252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03286
Pseudopodium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.123
promoter	GeneRIF Biological Term Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NS-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210655_3_v_4_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_63_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
CMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07435
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
ANKEF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35823
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE230263,GSE230265_5_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_66_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21034
activates	GeneRIF Biological Term Annotations	1.0	null
MPZL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71229
K562_Pirarubicin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209153
intercalated	GeneRIF Biological Term Annotations	1.0	null
BRD-K89175823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23416
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Combined-MYB_Combined_sgRNA_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
K562_PFI-1_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173688
IZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.925431
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838155
Raphe nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.638
Perturb_17045_KD_BATF3_SRP230607	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	15.1743
nucleus of the inferior collicular brachium, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1729
BRD-K37479727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23281
Nasal polyp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.64
GRIN2A	Pathway Commons Protein-Protein Interactions	1.0	null
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068775
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TAT protein transport complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.576
NSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82029
BRD-A52749901	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41934
Focal epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.354
NCIH522	CCLE Cell Line Gene CNV Profiles	-1.0	-2.43285
PBX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.95269
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-DEG_MDDC_C91-PL_LPS_vs_MDDC_Jurkat_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K66538269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22089
hsa-miR-335-5p	MiRTarBase microRNA Targets	1.0	null
K562_RG108_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170341
heart muscle	HPA Tissue Protein Expression Profiles	1.0	1.61878
H3K4me1_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
20460173-ImmPortComprehensiveListofImmune-RelatedGenes	GeneSigDB Published Gene Signatures	1.0	null
GOLM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63233
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
whole plant	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.52635
K562_Selisistat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0298699
BRD-K82619993	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42678
astroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.382884
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urethra	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.517284
secretion by cell	GO Biological Process Annotations 2015	1.0	null
CEBPB-26923725-CHIP-SEQ-MESODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
UT7	CCLE Cell Line Gene Expression Profiles	1.0	2.04132
abnormal gametes	MPO Gene-Phenotype Associations	1.0	null
bleeding disorder due to p2rx1 defect	OMIM Gene-Disease Associations	1.0	null
GART	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49183
Cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03311
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10715
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
Lung squamous cell carcinoma_LUSC_TCGA-85-A4PA-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K90548911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60826
REC1	CCLE Cell Line Gene Expression Profiles	1.0	1.85394
Lung squamous cell carcinoma_LUSC_TCGA-60-2709-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
synapse	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
NCIH1563	CCLE Cell Line Gene CNV Profiles	1.0	1.40407
K562_Rucaparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0225103
BRD-K07361992	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01071
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
significant	GeneRIF Biological Term Annotations	1.0	null
GSE110178_1_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054858
POU5F1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94917
Lung adenocarcinoma_LUAD_TCGA-55-7728-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Baricitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169176
Tunica externa vasorum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.337
CRLF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68542
HEK 293 T-rex    	BioGPS Cell Line Gene Expression Profiles	1.0	1.10412
breast	HPA Tissue Protein Expression Profiles	-1.0	-0.822334
basal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084251
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6392
ZNF284	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97413
FBLN5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00518369
Gata-4_KO_GDS4782_329_mouse_Adult heart during pressure overload	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18281
ELF1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-98	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
GTEX-S7PM-0426-SM-3NM91	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49485
FU97	DepMap CRISPR Gene Dependency	1.0	3.34536
dexamethasone_homo sapiens_gpl6244_gse20963	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cranial ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.628293
parabigeminal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.05902
AML193	CCLE Cell Line Gene CNV Profiles	-1.0	-1.53117
RUNX3	ENCODE Transcription Factor Targets	1.0	null
NCI-H358	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.29424
inhibit	GeneRIF Biological Term Annotations	1.0	null
Calcium signaling pathway	KEGG Pathways 2026	1.0	null
GTEX-S32W-1126-SM-4AD5V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910146
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949105
basal plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.266774
PPM1F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76344
BLM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23343
Interstitial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.415
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A24369193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22911
Triangular nucleus of septum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.60122
SP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63992
NEFL	Pathway Commons Protein-Protein Interactions	1.0	null
Toxic Encephalitis	DisGeNET Gene-Disease Associations	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TFAP2C_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
broxyquinoline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27186
superficial stratum of PHyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13166
PPARGC1B_Hypomorphic Mutation_GDS2515_695_mouse_Skeletal muscle - (quadriceps muscles)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
PALD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92898
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32806
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977116
glial cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.11812
MYOG_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cSARS Bat SRBD_12Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-2.61373
cytoplasmic vesicle membrane	GO Cellular Component Annotations 2025	1.0	null
Subthalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03177
Platelet homeostasis	Reactome Pathways 2024	1.0	null
iliac artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.164661
mesenteric artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.93577
GSE210655_3_v_7_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
arteries	GeneRIF Biological Term Annotations	1.0	null
GSE230263,GSE230265_6_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
skin	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053919
C10	DepMap CRISPR Gene Dependency	1.0	2.89463
D341MED	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46408
Cation channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.887
TMEM132A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.03078
coagulation	GO Biological Process Annotations 2015	1.0	null
reduced	GeneRIF Biological Term Annotations	1.0	null
vasoconstriction	GO Biological Process Annotations 2015	1.0	null
BRD-K12281552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31859
cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
GTEX-WRHK-1726-SM-3MJFK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14766
GR	MotifMap Predicted Transcription Factor Targets	1.0	null
K562_Pirarubicin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.018402
SNU1079	DepMap CRISPR Gene Dependency	1.0	2.6095
K562_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0254891
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.59935
TCF12/HEB-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
magnocellular (medial) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23735
PRPF38B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62085
BRD-K48900723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70742
SK-MEL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
alitretinoin_homo sapiens_gpl6480_gse43090	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-6829-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60337516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05105
K562_Tacedinaline_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0326724
BRD-A36774080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42741
KO52	CCLE Cell Line Gene CNV Profiles	-1.0	-1.81577
CMTM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6058
ZBTB32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50521
GSE216043_11_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T2YK-0008-SM-4DM6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79431
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S17-Table_S17_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-001_4E_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120595_0_v_4_arid2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CDK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4569
HNF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17939
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8254
TAFAZZIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93967
Communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.598
urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.056785
medial part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.44299
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45W-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K77697725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49725
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.25101
HCC2218	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35112
Rheumatoid Arthritis	DisGeNET Gene-Disease Associations	1.0	null
BRD-K28559679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25926
dlx4_00000000_mcfdash7_gof_human_gpl201_gse21657	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.184639
hsa-miR-4487	TargetScan Predicted Conserved microRNA Targets	1.0	0.15008
BRD-K70276322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81143
NFIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.0609
ZNF544	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97377
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4819-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gout	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.308
BRD-K36104357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36528
K562_Tubastatin A HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0306197
Presubiculum, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04166
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.389289
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.828437
GSE199081_0_v_1_insr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nucleotide receptor activity	GO Molecular Function Annotations 2023	1.0	null
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Y-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.848
Malaria	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
HS 69ST	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.853379
BRD-K32854540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07289
non-membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.051182
K562_Sirtinol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0758798
STXBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE89018_1_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3612	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
coronary	GeneRIF Biological Term Annotations	1.0	null
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.904106
K562_Dacinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183248
mediate	GeneRIF Biological Term Annotations	1.0	null
specific granule membrane	GO Cellular Component Annotations 2025	1.0	null
Neuron projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.246
GTEX-OHPM-2626-SM-33HC5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.94876
motoneuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.377996
STX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20375
adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052186
HINFP_02_36	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.63184
regulation of localization	GO Biological Process Annotations 2015	1.0	null
SPECC1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73963
GTEX-PVOW-2526-SM-2XCF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839023
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.77667
hsa-miR-4691-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
SPATA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99387
Perturb_12899_KD_IRF3_SRP298451	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	8.7061
BRD-K73394628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4503
BRD-K61438422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55761
GTEX-RTLS-0426-SM-2TF5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4111
K562_Entinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.023262
PAPOLB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84448
ZNF18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6695
SFRP5_KO_GDS4988_27_mouse_gonadal white adipose tissue HFD	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.5053
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.419
Primary somatosensory area, mouth, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.79507
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07771
H4C4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30562
RPL35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51663
MYBPC2	Pathway Commons Protein-Protein Interactions	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2977-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lower Urinary Tract Symptoms	DisGeNET Gene-Phenotype Associations	1.0	null
PRKCD	Pathway Commons Protein-Protein Interactions	1.0	null
UIMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63409
BRD-K12040459_AT7867_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
response to endogenous stimulus	GO Biological Process Annotations 2015	1.0	null
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49728
SB-202190-6887	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ERI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.61342
DMRT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6467
terminal nucleus of the stria medullaris	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36403
Glossopharyngeal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.346
BRD-K92440102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82451
BRD-K77518191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23722
PRKCA	Pathway Commons Protein-Protein Interactions	1.0	null
varicose veins	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.548195
K562_Mocetinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.027675
semen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.30032
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57768
subtypes	GeneRIF Biological Term Annotations	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.10279
GSE188458_2_v_1_hydrogen peroxide_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-1343	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
medial part of r9B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75105
GSE180200,GSE180201_3_v_9_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
distributed	GeneRIF Biological Term Annotations	1.0	null
esophagus_5c	HPA Tissue Sample Gene Expression Profiles	1.0	0.897104
HADH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36372
ACACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27565
ES-WA7 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.988515
Mast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.799
BRD-K41793515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24999
DFFA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.7804
Iliac artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.922
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855795
AIM2 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
GTEX-S32W-2426-SM-2XCAT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36805
Dense body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.831
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3CB-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vestibular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.387404
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.938571
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.244232
PMC12913833-12672_2026_4481_MOESM3_ESM.xlsx-Table_S1-Table_S1_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
TPMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57224
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72416
K562_Tucidinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0314186
TMEM238	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85763
regulation of multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
GSE81193_3_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellar purkinje cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.462239
GTEX-NFK9-0008-SM-4E3JE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28294
p2x7r	GeneRIF Biological Term Annotations	1.0	null
action	GeneRIF Biological Term Annotations	1.0	null
BRD-K18000429	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15329
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.67039
Mesothelioma_MESO_TCGA-TS-A7P8-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.385
Main olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08422
Synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.247
PHLDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88702
MON	DepMap CRISPR Gene Dependency	1.0	2.36159
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
trichostatin A-2370	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21387
purinergic nucleotide receptor activity	GO Molecular Function Annotations 2023	1.0	null
Thrombosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.188
positive regulation of cysteine-type endopeptidase activity	GO Biological Process Annotations 2015	1.0	null
calcium ion transmembrane transport	GO Biological Process Annotations 2025	1.0	null
WHSC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4733-01A-02R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Blood	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
OVMANA	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35621
GSE129241_4_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA	ChEA Transcription Factor Targets 2022	1.0	null
Chronic obstructive pulmonary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.73
MYOG	ENCODE Transcription Factor Targets	1.0	null
PPOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65057
Lung adenocarcinoma_LUAD_TCGA-55-8206-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
extracellular region	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.998577
stratum oriens of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.18684
COLO-741	GDSC Cell Line Gene Expression Profiles	-1.0	-2.0851
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MSANTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17405
GSE234637_2_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MHHCALL2	CCLE Cell Line Gene Expression Profiles	1.0	1.67914
SLC25A27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90897
BRD-K72379955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29541
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.795
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.62886
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
collagen	GeneRIF Biological Term Annotations	1.0	null
scanning	GeneRIF Biological Term Annotations	1.0	null
ARMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20539
cation binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01304
GSE218060_1_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXP1-21924763-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
K562_Nintedanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0220939
reproductive process	GO Biological Process Annotations 2015	1.0	null
CCNT2	ENCODE Transcription Factor Targets	1.0	null
BRD-K69350688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.10277
GSE139911_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TUBA4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509624
Presynaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.901
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909034
small intestine	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.28107
RPS20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51368
marrow	GeneRIF Biological Term Annotations	1.0	null
BRD-K77953978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05645
GSE140646_0_v_1_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hyperglycemia	DisGeNET Gene-Disease Associations	1.0	null
Irritable bowel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.478
MYL6B	Pathway Commons Protein-Protein Interactions	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-58-8386-11A-01R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Longitudinal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.347
GFUS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30239
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42122
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.084006
Kidney Chromophobe_KICH_TCGA-KO-8408-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
SOX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46864
SORT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00409751
CRCGN017_MCF10A.WT.HP_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10915
Lacrimal apparatus disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.246
NUAK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25378
PMC4243378-13059_2014_494_MOESM1_ESM.xlsx-S1_6_Gene_sets_CIITA_BIs-All_CIITA_not_RFX5_RFX5	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Mesna_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022857
PRKCZ	Pathway Commons Protein-Protein Interactions	1.0	null
CXADR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77458
GSE173394_1_v_0_nfatc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TSE9-0426-SM-3DB81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24936
Placenta	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Brain ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.604
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TIMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45018
IL17RD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39338
RMND5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71812
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dilated cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.703134
CAPAN-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DQ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Myelocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.598
spleen	GeneRIF Biological Term Annotations	1.0	null
SNRPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56577
Medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1971
gallamine triethiodide-1375	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Human immunodeficiency virus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.2
HELB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56073
U266B1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74337
FRG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88601
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.8046
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0207
Lung squamous cell carcinoma_LUSC_TCGA-51-4081-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KCL-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
blood vessel	GTEx Tissue Gene Expression Profiles	1.0	1.21478
positive regulation of transport	GO Biological Process Annotations 2015	1.0	null
mutagenesis	GeneRIF Biological Term Annotations	1.0	null
K562_FLLL32_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0224832
BRD-K10564128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03187
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.65544
CTV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Major Depressive Disorder	DisGeNET Gene-Disease Associations	1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.20044
Muscular coat	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.246
Uterine Carcinosarcoma_UCS_TCGA-NG-A4VU-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.861046
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911929
lateral part of r7B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01323
cochlear duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.348519
PRDX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72195
BRD-K37865854	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22601
rostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.89237
GSE165682_4_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
response to stimulus	GO Biological Process Annotations 2015	1.0	null
HCC1419	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.919988
Anterior hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1456
Brain cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.413
SREBF2	JASPAR Predicted Transcription Factor Targets	1.0	null
PHKG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4401
ZC3H11A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
COLO792	DepMap CRISPR Gene Dependency	1.0	2.35427
Sarcoma_SARC_TCGA-FX-A3NJ-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5939-11A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
organonitrogen compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
gating	GeneRIF Biological Term Annotations	1.0	null
Sciatic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.47
substrate-specific channel activity	GO Molecular Function Annotations 2015	1.0	null
GSE152441,GSE152442_7_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0395729
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
organic hydroxy compound transport	GO Biological Process Annotations 2015	1.0	null
nuclear part	GO Cellular Component Annotations 2015	1.0	null
Head	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
establish	GeneRIF Biological Term Annotations	1.0	null
BRD-K76166595	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44263
GSE234340_3_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GFI1B	ChEA Transcription Factor Targets	1.0	null
SHSY5Y	DepMap CRISPR Gene Dependency	1.0	2.05854
ESPN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00622
BRD-K73479560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12102
studies	GeneRIF Biological Term Annotations	1.0	null
DCAKD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12397
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
external side of cell outer membrane	GO Cellular Component Annotations 2015	1.0	null
PMC11024925-mmc3.xlsx-Gene_lists-MV411_FOS_ChIP_and_RNA_overlap_after_10_nM_Gilteritinib_FOS	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_TCGA-GBM-IRF6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CFAP157	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48509
anteroventral periventricular preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.9723
bone	GeneRIF Biological Term Annotations	1.0	null
Internal carotid artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.787
leading edge membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.339261
FOXO1::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.0559
ATP2B4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55269
SK-N-AS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72581
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.433407
GSE223008_4_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8125
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	79.8512
GTEX-UTHO-0008-SM-4JBID	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46947
BRD-K82935855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12713
collagenevoked	GeneRIF Biological Term Annotations	1.0	null
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053269
immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043667
clinical	GeneRIF Biological Term Annotations	1.0	null
LMO2	ChEA Transcription Factor Targets	1.0	null
Aortic body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.823
K562_Mocetinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256765
K562_Danusertib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0329357
periventricular stratum of r4Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50089
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.4935
BRD-K92632379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71596
purine ribonucleoside triphosphate binding	GO Molecular Function Annotations 2015	1.0	null
E2A-27217539-CHIP-SEQ-RAMOS-CELL-LINE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CD34+	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.63167
preoptic telencephalon	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.45074
regulation of calcium ion transport	GO Biological Process Annotations 2015	1.0	null
cardiomyocytes	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-611	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
BRD-K09521953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.63516
K562_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205659
synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.612048
KRT19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41478
primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.951176
PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-17p13_1_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
HEG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98487
t30-blood-rna_male_8w	MoTrPAC Rat Endurance Exercise Training	1.0	5.17825
single-organism biosynthetic process	GO Biological Process Annotations 2015	1.0	null
osteomyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.282582
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
Declive (VI), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1746
atp	Phosphosite Textmining Biological Term Annotations	1.0	null
SBK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36211
H3C11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14025
CNOT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.70434
GSE211126_3_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.577
GSE162015_2_v_0_nfkb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.023911
ZNF143	ENCODE Transcription Factor Targets	1.0	null
TBC1D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49683
GTEX-QCQG-0008-SM-48U2G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.986068
PHA-00767505E-6545	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_30_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
RLIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98686
neuron projection membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.347208
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A74H-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
fallopiantube_8c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.931535
pregnancy	GeneRIF Biological Term Annotations	1.0	null
GTEX-S33H-0008-SM-4AD6C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34754
K562_Cerdulatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0448848
ZNF417	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6446
salivary gland epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.289939
external encapsulating structure part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
membrane raft	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.381969
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
ZNF69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62098
Periglomerular cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.56
TTC709	DepMap CRISPR Gene Dependency	1.0	4.43637
PDE10A_KO_GDS4542_291_mouse_striatum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
K562_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0337657
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08628
GlobusPallidus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.923232
dorsolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40816
H3K27ac_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
BRD-K72519622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21231
K562_PF-3845_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0298041
TCF24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13271
TAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22409
GTEX-P4QT-0008-SM-48TDZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23298
Rectum adenocarcinoma_READ_TCGA-F5-6464-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE174498,GSE174500_5_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
medial part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03114
K562_Meprednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0267142
SYT5	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92613860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13104
CNGB1	Pathway Commons Protein-Protein Interactions	1.0	null
MAPK14_KO_GDS2693_535_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-A88691416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19635
superficial stratum of m2ADL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39759
response to chemical	GO Biological Process Annotations 2015	1.0	null
Diabetic Nephropathy_Renal Tissue_GSE1009	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	0.400509
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-R55D-0008-SM-48FEV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50885
cerebellar cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.85092
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.840635
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.058
GTEX-P4PP-0008-SM-48TDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72352
Acute Myeloid Leukemia_LAML_TCGA-AB-2994-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K24977393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55285
GSE223008_5_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
P2X purinoreceptor extracellular domain	InterPro Predicted Protein Domain Annotations	1.0	null
K562_ITSA-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236269
nose	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.285671
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
Colon descendens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.542
dipyridamole-2017	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_Aminoglutethimide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238011
POLR2AphosphoS5_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPFIA4	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN013_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.01694
SNU-C2B	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QCQG-1926-SM-2S1PI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33355
CRCGN011_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.1712
agonistinduced	GeneRIF Biological Term Annotations	1.0	null
BRD-K88676137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19181
GSE199606_6_v_4_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
K562_Dacinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0253539
DMC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51666
epidermis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055266
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.835
GSE110178_5_v_0_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-let-7i	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
GATA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08335
TAL1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE118794_0_v_1_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A513-01A-12R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.98152
GSE74490_0_v_1_triptolide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825221
characterized	GeneRIF Biological Term Annotations	1.0	null
GTEX-TSE9-0008-SM-4DXT8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20793
GSE164364_2_v_3_zymosan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3650	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.03779
neuromuscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.067924
Lung adenocarcinoma_LUAD_TCGA-55-8508-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
gastrointestinal tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.289226
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3094
regulation of blood pressure	GO Biological Process Annotations 2015	1.0	null
leukemia	GeneRIF Biological Term Annotations	1.0	null
hippocampus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.289939
Anterior cingulate area, ventral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83932
vascular	GeneRIF Biological Term Annotations	1.0	null
BRD-K27760381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11427
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.72724
SWAP70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35813
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Perivascular astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.938
ventrolateral prefrontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23922
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.80563
excitatory extracellular ligand-gated monoatomic ion channel activity	GO Molecular Function Annotations 2023	1.0	null
Trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.146
TNNI1	Pathway Commons Protein-Protein Interactions	1.0	null
ACTG2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
furosemide-1580	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
predominantly	GeneRIF Biological Term Annotations	1.0	null
FCRLA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00672663
KASUMI6	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33618
GSE150665,GSE150667_1_v_5_mysm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
D283MED	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46904
RUNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56027
r7 part of the dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.33119
thymus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.226667
cellular_component	GO Cellular Component Annotations 2015	1.0	null
BRD-K72255851	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00424
Perturb_1022_KO_Ggps1_SRP238706	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
NR5A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.47136
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.838
EEF1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-7.82121
Autonomic nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
Plateletcrit	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.830103
K562_NVP-BSK805 2HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0330447
NALM19	CCLE Cell Line Gene Expression Profiles	1.0	1.54207
inner ear	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.34963
CRCGN010_HEPG2_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01245
CREB1-26743006-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
valproic acid_homo sapiens_gpl570_gse14973	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cytoskeletal	GeneRIF Biological Term Annotations	1.0	null
ZNF300	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86258
A1BG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00664208
GSE110178_4_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
positive regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE129287_0_v_1_cd200_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RWS6-0008-SM-47JYV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0806
Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A5BI-01A-31R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cochlea	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.302838
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K96322674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64038
GSE188884,GSE189078_2_v_3_ebf1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EFEMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50445
organelle inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML2-CLOSEST_GENE_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
rear	GeneRIF Biological Term Annotations	1.0	null
Parkinson Disease	DisGeNET Gene-Disease Associations	1.0	null
COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.117
serotonin secretion	GO Biological Process Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H3-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.216
calcium channel activity	GO Molecular Function Annotations 2015	1.0	null
K562_Momelotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0806106
CREB1_01_195	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.28794
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62561
Schwann cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.409
corpus cavernosum penis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.621024
K562_Rucaparib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0515887
Capillary pericyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.119
bone marrow	HPA Tissue Gene Expression Profiles	1.0	1.07087
hsa-let-7b	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
eucatropine-3759	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
depending	GeneRIF Biological Term Annotations	1.0	null
PRKAA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07362
Dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22859
r3 alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41146
496100514_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0433
BRD-K73149920	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33588
GSE235596_0_v_1_pikfyve_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_BMS-754807_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206305
K562_GSK1070916_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0372053
Idiopathic Pulmonary Arterial Hypertension	DisGeNET Gene-Disease Associations	1.0	null
r7 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09869
SCN4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.21655
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Juxtaglomerular apparatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.274
Presynapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.062
KLHL15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22185
brain cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.344449
K562_Cerdulatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0651325
BRD-K37657049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08989
GSE110178_2_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RP-01A-21R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MYH11	Pathway Commons Protein-Protein Interactions	1.0	null
Amoeba	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.964
hsa-miR-128	TargetScan Predicted Conserved microRNA Targets	1.0	0.404082
K562_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0201882
ZFP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07033
Pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.011
SNU213	CCLE Cell Line Gene Expression Profiles	-1.0	-2.37597
Lung squamous cell carcinoma_LUSC_TCGA-34-7107-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MYC_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68672
BRD-K25917968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11267
GSE131649_2_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC827	CCLE Cell Line Gene CNV Profiles	1.0	1.49271
Renal artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.125
BRD-K98841583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13084
BON-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.821
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-RXRG_RXRG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1972
positive regulation of endopeptidase activity	GO Biological Process Annotations 2015	1.0	null
vasodilation	GeneRIF Biological Term Annotations	1.0	null
GTEX-XMD3-0008-SM-4AT4V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17172
neuron part	GO Cellular Component Annotations 2015	1.0	null
GSE131649_4_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ACTA2	Pathway Commons Protein-Protein Interactions	1.0	null
WholeBlood	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.959717
NCOR1-26117541-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1062
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A81879813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82882
Cortical collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.822
Monocyte_Fetal kidney_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE142588_2_v_0_cinobufagin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08261
Membrane microdomain	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
Tongue epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.268
GSE142684_2_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K10144853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53147
myeloid progenitor cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-REST_REST	Rummagene Transcription Factor Associations 2026	1.0	null
NOMO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41362
YH13	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32059
GTEX-UPJH-0726-SM-4IHJW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82058
RUNX1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88274
DHX30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00049
RBM26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54489
K562_SGI-1776 free base_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0299086
GSE250534_4_v_1_cabergoline_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
rhombomere 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44267
IRF1	ENCODE Transcription Factor Targets	1.0	null
Saphenous vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.985
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
pulmonary hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.263722
Paraventricular hypothalamic nucleus, parvicellular division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.32464
axolemma	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.348346
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8663
GSE210580_4_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CUX1	ChEA Transcription Factor Targets	1.0	null
GSE203060_0_v_1_kdm4c_human	RummaGEO Gene Perturbation Signatures	1.0	null
Renal distal tubule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.071
GTEX-UPK5-0008-SM-4IHJD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.40836
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.477367
BRD-K49529874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.35118
extracellular matrix part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.426711
K562_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0259309
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SUP-T1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87523
Autoimmune disease of skin and connective tissue	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.079
inner SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.849998
MOLM6	CCLE Cell Line Gene Expression Profiles	1.0	1.69739
GSE114690_1_v_0_tnfsf14_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K01660763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80449
K562_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0654722
GSE225656_2_v_3_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-AAQO-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K93339508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3756
tyrosine	GeneRIF Biological Term Annotations	1.0	null
RIOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.49196
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9852
should	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20R-11A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head And Neck Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
monoatomic cation channel activity	GO Molecular Function Annotations 2025	1.0	null
imatinib_homo sapiens_gpl96_gds3049	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-U3ZN-0008-SM-4DXTL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20686
DDHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67607
BRD-K07602825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43784
PMC6664293__F4	PFOCR Pathway Figure Associations 2024	1.0	null
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
regulator	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-7022-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Microglial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.361
Colon muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.06
GTEX-WY7C-2826-SM-3NB3Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34737
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cho cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.126304
nucleotide receptor activity	GO Molecular Function Annotations 2025	1.0	null
urgency	GeneRIF Biological Term Annotations	1.0	null
16643655-1300GenesList	GeneSigDB Published Gene Signatures	1.0	null
GSE220813_0_v_1_zfp750_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300	ENCODE Transcription Factor Targets	1.0	null
Ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.075
H3K27ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K29218981	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18038
K562_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0221937
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200666
PRKCB	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.68493
SPNS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00515814
MAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8956
cell surface	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.371599
BRD-K76620631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55956
CRCGN014_HEPG2_3H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13939
pindolol-1392	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RN64-0526-SM-2TC5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69548
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.28786
Arteriosclerosis	DisGeNET Gene-Disease Associations	1.0	null
C1orf50	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07171
HEY	COSMIC Cell Line Gene Mutation Profiles	1.0	null
renal artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.2559
NCI-SNU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
DCAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90521
OVISE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.912176
YY1	ENCODE Transcription Factor Targets	1.0	null
GSE182680,GSE182683_7_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE241031_0_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
decreased litter size	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K20415826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95228
K562_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181331
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
INF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09865
APELA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35762
BRD-K14210122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38627
Glial cell projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.026
K562_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186594
CTCF_G1E-ER4_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40971
BRD-K60952519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59376
FOXP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.00362
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72363
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
DACH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10298
GTEX-SJXC-0008-SM-4DM7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30904
BRD-K18290923	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06258
L-ΒΓ-MEATP	DGIdb Drug Targets 2026	1.0	4.812
GABA-A receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.041
Paraflocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07843
DLG4	Pathway Commons Protein-Protein Interactions	1.0	null
CNGA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE128844_0_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Principal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
MTA3	ENCODE Transcription Factor Targets	1.0	null
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.979065
raphe obscurus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03443
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5682-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73202
Squamous Cell Carcinoma Of The Head And Neck	DisGeNET Gene-Disease Associations	1.0	null
BRD-K49755501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06091
PMC5110542-Data_Sheet_2.XLS-EE_SRF-2000-2015_QIAGEN_All_rights_reserved_SRF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
drug binding	GO Molecular Function Annotations 2015	1.0	null
PMC5768349__F4	PFOCR Pathway Figure Associations 2024	1.0	null
Exocrine acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.005
indusium griseum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0635
GTEX-O5YV-1626-SM-2YUNJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10211
hsa-miR-4644	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GTEX-X5EB-0008-SM-46MU3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57747
TIMM29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48042
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CD99	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26641
contributing	GeneRIF Biological Term Annotations	1.0	null
endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.797291
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1695
K562_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0160846
PMC11067031-pnas.2317690121.sd03.xlsx-gene_list_-_2022-04-13T081711_1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_mouse_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
spiral organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.368998
glial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.108834
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03113
K562_CEP-33779_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0332394
GTEX-QV44-0008-SM-447AX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95431
RUNX1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MTFR1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39872
PPFIA2	Pathway Commons Protein-Protein Interactions	1.0	null
BMI1	ChEA Transcription Factor Targets	1.0	null
parenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.218398
Rectum adenocarcinoma_READ_TCGA-AH-6643-11A-01R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE150665,GSE150667_4_v_5_mysm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1103
ZNF789	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91925
Lung adenocarcinoma_LUAD_TCGA-44-2668-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hypertension	MPO Gene-Phenotype Associations	1.0	null
GSE110178_5_v_6_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XBED-0526-SM-47JY3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826574
JUN	JASPAR Predicted Transcription Factor Targets	1.0	null
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
inorganic cation transmembrane transport	GO Biological Process Annotations 2015	1.0	null
TNNI2	Pathway Commons Protein-Protein Interactions	1.0	null
Granule cell layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.797
K562_PD173074_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185036
first (dorsal) preoptic domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34457
rhombomere 3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05227
K562_Entinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239459
CASP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00596214
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.32849
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
diabetes	GeneRIF Biological Term Annotations	1.0	null
GSE169152_5_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
culture medium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.424581
GSE147662_3_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MBLAC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25905
CRCGN015_HEPG2_48H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41406
NALM1	CCLE Cell Line Gene Expression Profiles	1.0	1.76098
K562_Momelotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.01666
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TLDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1454
WHSC1	ENCODE Transcription Factor Targets	1.0	null
primary motor cortex (area M1, area 4)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13672
BRD-K01263144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.05715
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PSDG-0526-SM-2S1OH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16268
CHD2_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TNNC2	Pathway Commons Protein-Protein Interactions	1.0	null
K562_BMS-265246_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0211858
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_75_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205163,GSE205164_3_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6132-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.14387
positive	GeneRIF Biological Term Annotations	1.0	null
NCI-H2141	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PPFIA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92597
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.7047
cation channel activity	GO Molecular Function Annotations 2015	1.0	null
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05845
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.467
SNB19	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.20152
GSE174498,GSE174500_0_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mast cell granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.756
ALS2CL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71627
GSE157594_0_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
outer CP in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.41523
Febrile Convulsions	DisGeNET Gene-Disease Associations	1.0	null
PL21	CCLE Cell Line Gene Expression Profiles	1.0	3.40798
intermediate stratum of m1AL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28121
nuclear inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
gpibvwf	GeneRIF Biological Term Annotations	1.0	null
NCIH2087	CCLE Cell Line Gene CNV Profiles	1.0	1.50549
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.48
Resting cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.103
Intestinal muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.103
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0194683
GSE89018_11_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
platelet storage pool deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.920085
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
excitatory extracellular ligand-gated ion channel activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-S4P3-1826-SM-3K2AL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62161
BRD-K08881846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20594
Cervical ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.062
Spinal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.051
inner CP in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.947295
GTF2F1_02_110	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.58496
Paraventricular hypothalamic nucleus, magnocellular division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.21982
m15	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.608
OSBPL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65349
cell envelope	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GTEX-U412-0226-SM-3NMC8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2901
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26107
GABARAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61522
Supramammillary nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06329
Olfactory organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.75
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
CAMK2A	Pathway Commons Protein-Protein Interactions	1.0	null
17555561-Table2	GeneSigDB Published Gene Signatures	1.0	null
caused	GeneRIF Biological Term Annotations	1.0	null
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.938824
MYH8	Pathway Commons Protein-Protein Interactions	1.0	null
TGIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28901
Osteoclastoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.842
16024625-Table1	GeneSigDB Published Gene Signatures	1.0	null
Thymocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.327
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.699
Fatty Liver Disease	DisGeNET Gene-Disease Associations	1.0	null
Platelet storage pool deficiency	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.213
Prostate adenocarcinoma_PRAD_TCGA-G9-6499-11A-02R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FBXO11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30108
Degeneration of macula and posterior pole	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.015
ZNF341	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6741
BRD-K06611347	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.65262
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RNF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63489
PMC7305081-10120_2020_1045_MOESM1_ESM.xlsx-Tab2-Mutation-MAF_MAF	Rummagene Transcription Factor Associations 2026	1.0	null
Endocrine organ benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
purine nucleoside binding	GO Molecular Function Annotations 2015	1.0	null
BRD-A69648159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21342
KYSE-150	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10828
SIPA1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74174
K562_EED226_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159483
RPL41	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36019
TCF3	ENCODE Transcription Factor Targets	1.0	null
DNAJB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62685
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2712-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_TG101209_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0265701
rearrangements	GeneRIF Biological Term Annotations	1.0	null
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Synaptic cleft	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.733
BRD-K61555339	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41026
BRD-K72787967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35045
GTEX-QXCU-0006-SM-2TC5K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840497
GSE195559_8_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69934
array	GeneRIF Biological Term Annotations	1.0	null
BRD-A61767497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24103
calcium ion transport	GO Biological Process Annotations 2015	1.0	null
HACD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83425
K562_Thiotepa_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0342835
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
IER3IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24723
CUX1	ENCODE Transcription Factor Targets	1.0	null
BRD-K45819372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13039
GSE216352,GSE216354_1_v_0_keap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
FAM217B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65259
time	GeneRIF Biological Term Annotations	1.0	null
BRD-K81450614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24539
AMPA glutamate receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.21
ADRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08746
calcium ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195559_8_v_5_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cytoplasmic membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.384665
ASPHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66951
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883147
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.85706
FOXD4L5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53311
MOLM14	DepMap CRISPR Gene Dependency	1.0	2.52079
ligand-gated ion channel activity	GO Molecular Function Annotations 2015	1.0	null
PYGM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20974
spanning component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.739614
K562_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.029801
signaling	GO Biological Process Annotations 2015	1.0	null
lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.24531
close	GeneRIF Biological Term Annotations	1.0	null
thorax	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061351
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.72416
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.283
TIMM44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2015
GSE181003_3_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GAREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7601
POLR2G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08992
external encapsulating structure	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
KANSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01482
K562_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.02372
regulation of metal ion transport	GO Biological Process Annotations 2015	1.0	null
decreased	GeneRIF Biological Term Annotations	1.0	null
GDM1	CCLE Cell Line Gene Expression Profiles	1.0	2.25274
K562_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0579502
CHSY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47385
Kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.218
K562_PF-573228_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163633
AKAP9	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Trichostatin A_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182283
Myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.527
K562_Lapatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0392275
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S5-Table_S5_The_result_of_MR_analysis_and_sensitivity_analysis_for_FVC_decline_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Superior cervical ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.076
BRD-K35462787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00361
Granulomatous Disease, Chronic_Blood neutrophil_GSE935	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.43107
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BF-11A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.28095
TUBA4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4928
Dorsal fin	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.207
ion	GeneRIF Biological Term Annotations	1.0	null
LIMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27188
RTF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21441
responsiveness	GeneRIF Biological Term Annotations	1.0	null
Medulla oblongata	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.233
GSE234340_3_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Extracellular region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.632
connexin43	GeneRIF Biological Term Annotations	1.0	null
BRD-K01676126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0378
Mastocytoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.586
PMC12354852-41467_2025_62818_MOESM3_ESM.xlsx-Sup_Data_10-Differentially_expressed_genes_in_TAF6L_KD_vs_Control_AR	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.83615
secretion	GO Biological Process Annotations 2015	1.0	null
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Mueller cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.157
CHP-100 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.625
GSE159678_6_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.82
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.89949
P2RY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92601
Lung squamous cell carcinoma_LUSC_TCGA-22-1011-01A-01R-0692-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vertebrate muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN015_MCF10A.WT.HP_24H:F17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.27958
signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_24_human_DRSG_higherRes-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_TAK-901_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196214
detrusor	GeneRIF Biological Term Annotations	1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0509
Perturb_1393_KO_Rad9_SRP214104	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.48789
CRCGN015_HEPG2_48H:F02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22725
EGR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16201
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.04577
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.466
single-organism localization	GO Biological Process Annotations 2015	1.0	null
K562_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152114
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.359
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988822
efs	GeneRIF Biological Term Annotations	1.0	null
Intraocular Pressure Disorder	DisGeNET Gene-Disease Associations	1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.935
GTEX-SIU8-0008-SM-4BRUC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926036
LRATD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74053
parvocellular part of r8LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.32645
conformational	GeneRIF Biological Term Annotations	1.0	null
MERO48A	DepMap CRISPR Gene Dependency	1.0	2.19426
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
integral component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.233817
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Corn silk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.054
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-8_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
CCDC137	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14649
single-organism process	GO Biological Process Annotations 2015	1.0	null
plumule	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064655
GSE233679_14_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pia mater	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.552
superficial stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33927
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17124
GTEX-QV31-1626-SM-2S1QC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46886
K562_CEP-33779_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161311
GLI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44036
Crus 2, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15358
PMC11067031-pnas.2317690121.sd05.xlsx-Sheet1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K85708426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50922
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892528
Tuberculosis	DisGeNET Gene-Disease Associations	1.0	null
mantle zone of r7BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01189
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
BRD-K75815721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.443
BRD-K46715415	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0016
GSE158458_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
U937	CCLE Cell Line Gene Expression Profiles	1.0	1.51218
TGFBI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68157
Bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.185
K562_Dasatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0460439
CEBPB	ENCODE Transcription Factor Targets	1.0	null
Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE9375	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.03795
Liver hepatocellular carcinoma_LIHC_TCGA-RG-A7D4-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38574421	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2757
Cerebellar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07551
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
roof plate of p2 (epithalamic roofplate)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15077
evokes	GeneRIF Biological Term Annotations	1.0	null
K562_Tozasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0231826
ARC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.52
ZNF737	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84174
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z2-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17092
blast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.153595
influx	GeneRIF Biological Term Annotations	1.0	null
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.34752
BRD-K21483524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.9269
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.304
GSE207582_4_v_3_testosterone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MARK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19005
Perturb_12523_KD_Linc00673_SRP212104	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE216043_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K18307373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67508
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-1_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.98031
phaeochromocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.788033
K562_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.045718
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	1.0	1.20707
GTEX-XQ8I-0826-SM-4BOOE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72399
GTEX-SE5C-0008-SM-4B64J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39508
GTEX-XUW1-0008-SM-4BOQH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33077
organ	GeneRIF Biological Term Annotations	1.0	null
HEL	CCLE Cell Line Gene Expression Profiles	1.0	1.35947
GTEX-RNOR-0008-SM-48FEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2257
MRPL52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06382
U0125-663	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
brain cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.142871
K562_AG-14361_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0316824
RT11284	CCLE Cell Line Gene Expression Profiles	-1.0	-1.68439
GSE210476_11_v_10_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Platelet calcium homeostasis	Reactome Pathways 2014	1.0	null
PMC8901773-41598_2022_7986_MOESM3_ESM.xls-LPS_vs_CTR-Gene_symbol_ENSEMBL_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.3273
GSE150055_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_51_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE169152_3_v_2_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
GATA1_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6942-01A-21R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FLI1	ChEA Transcription Factor Targets	1.0	null
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12966
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.24341
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
purine nucleotide binding	GO Molecular Function Annotations 2015	1.0	null
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.24297
GRIN2B	Pathway Commons Protein-Protein Interactions	1.0	null
integument	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.938347
SLITRK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9333
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
xenopus	Phosphosite Textmining Biological Term Annotations	1.0	null
BDCA4+_DentriticCells	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.05169
olfactory bulb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.222938
JARID1B-DAIN-22020125-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
extracellular atp-gated cation channel activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K31059261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71097
PU.1	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K46015322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05179
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_39_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH716	DepMap CRISPR Gene Dependency	1.0	2.51601
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H2452	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.95269
BRD-K24076516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02867
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
stimulating	GeneRIF Biological Term Annotations	1.0	null
STAT5A	ENCODE Transcription Factor Targets	1.0	null
Uroepithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.636
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MR-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPS6KA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.96038
K562_MC1568_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157194
P2RX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055632
TMEM69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52585
GSE226091,GSE226092_3_v_2_sall1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VPS28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65873
BRD-K31390971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85096
BRD-K00137579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37056
K562_Daphnetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0275552
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-U3ZM-0826-SM-4DXU6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7781
CHST14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80115
Astroglial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.18
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH2452	CCLE Cell Line Gene CNV Profiles	1.0	1.46694
ca2	GeneRIF Biological Term Annotations	1.0	null
ABHD14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49069
FLI1_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tcell	GeneRIF Biological Term Annotations	1.0	null
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.753623
NR2F2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE168807_0_v_8_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF521	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81436
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE180200,GSE180201_15_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Secretory vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.91
acting	GeneRIF Biological Term Annotations	1.0	null
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_36_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186396
marrow cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.163783
ITPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22684
Congestive Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
Migraine	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.717
respiratory mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.260945
K562_Vandetanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0354711
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.8917
K562_Obatoclax Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0260645
K562_Linifanib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173288
GTEX-X88G-0008-SM-47JWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07973
ERBB2_druginhibition_7_GDS2139	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.90784
GSE216043_11_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
SLC66A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33752
GSE116930,GSE116935_1_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Mesothelioma_MESO_TCGA-LK-A4O4-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13J-11A-13R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.43015
MV411	CCLE Cell Line Gene Expression Profiles	1.0	1.95855
anterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00733
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.448346
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.571219
receptormediated	GeneRIF Biological Term Annotations	1.0	null
K562_Decitabine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0193254
JAR	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Table_S2_List_of_TAL1_UTX_co-bound_genes_in_Jurkat_cells_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF257	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97295
GSE234155_7_v_1_nfix_human	RummaGEO Gene Perturbation Signatures	1.0	null
Arthritis	DisGeNET Gene-Disease Associations	1.0	null
Extraglomerular mesangial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.849
Polymorphonuclear neutrophil	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.137
GSE126463_6_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Periodontitis	DisGeNET Gene-Disease Associations	1.0	null
EGR1	ENCODE Transcription Factor Targets	1.0	null
artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.055811
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.949
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4795
BRD-K92974694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46671
K562_SL-327_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0239256
BRD-A20731954	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24078
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ROCK_INHIBITION_GDS3944_463_mouse_Forebrain astrocytes - 12 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
abnormal spermatogenesis	MPO Gene-Phenotype Associations	1.0	null
blood platelet	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Median nucleus of thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.141
GSE147662_2_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Pars reticulata	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.624
BRD4-27068464-CHIP-SEQ-AML-CELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
abnormal gametogenesis	MPO Gene-Phenotype Associations	1.0	null
K562_Alvespimycin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199151
K562_NVP-BSK805 2HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182025
GSE216043_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRKAR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20408
cytoskeleton	GeneRIF Biological Term Annotations	1.0	null
ureter	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.421148
Neuron projection terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.249
parasolitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38096
19605494-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Perturb_1701_OE_CLK3_SRP128920	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-15.6986
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51H-06A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_PD173074_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0332472
Lung squamous cell carcinoma_LUSC_TCGA-39-5030-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rhombomere 11	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.57133
seedling	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063233
carbohydrate derivative binding	GO Molecular Function Annotations 2015	1.0	null
COV318	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.5383
GSE160817_4_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TP63	ChEA Transcription Factor Targets	1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GSKIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36269
SAP30L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91505
BRD-K01772946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55165
Atherosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.628
PRR36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80395
ZFP36_Deficiency_GDS2456_707_mouse_Fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Circular smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.713
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09293
K562_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0254069
GSE164364_0_v_3_zymosan_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Associated_Gene_Name_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8212786-DataSheet_4.xlsx-CESC-ZBED3_ZBED3	Rummagene Transcription Factor Associations 2026	1.0	null
K562_PJ34_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0533723
GTEX-XV7Q-0008-SM-4BRWL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03922
protein oligomerization	GO Biological Process Annotations 2015	1.0	null
NDC80	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18948
EP300_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0211517
K562_Temsirolimus_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187365
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.52453
Pulmonary Fibrosis	DisGeNET Gene-Disease Associations	1.0	null
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0341
BRD-K75429775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33433
BRD-K37033753	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.536
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
BRD-K57019930_1288-0508_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
positive regulation of cell death	GO Biological Process Annotations 2015	1.0	null
GTEX-T2IS-0008-SM-4DM75	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15371
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8003-01A-21R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
transduction	GeneRIF Biological Term Annotations	1.0	null
LMO2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
K562_GSK1070916_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0231653
K562_RG108_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216905
transition metal ion binding	GO Molecular Function Annotations 2015	1.0	null
CRCGN017_MCF10A.WT.HP_24H:E01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.93142
C11orf54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53885
extracellularly ATP-gated monoatomic cation channel activity	GO Molecular Function Annotations 2023	1.0	null
periventricular stratum of cerebellar vermis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.0453
tretinoin-224	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4533	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-S4Z8-1226-SM-4AD6W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14663
urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.18472
Lateral septal nucleus, caudal (caudodorsal) part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.4701
chlorphenesin-2279	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VIPR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18466
NELFE	ENCODE Transcription Factor Targets	1.0	null
GSE119345_2_v_3_bexarotene_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987391
pregeniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15276
nuclear membrane part	GO Cellular Component Annotations 2015	1.0	null
alexidine-7397	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE213410_0_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRL-0008-SM-3NB29	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17554
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_AZ 960_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020714
diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.231102
BRD-K03554945	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3197
GSE196117_1_v_8_clarithromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
rostral ventrolateral medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.602088
protein complex	GO Cellular Component Annotations 2015	1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
low	GeneRIF Biological Term Annotations	1.0	null
muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.703536
positive regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21414
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.0527
IKZF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5221
GTEX-QDVN-0126-SM-4GIC9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860081
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.07549
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22185
monoatomic ion transport	GO Biological Process Annotations 2023	1.0	null
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Amacrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.881
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.37949
receptors	Phosphosite Textmining Biological Term Annotations	1.0	null
control	GeneRIF Biological Term Annotations	1.0	null
eGFP-NR4A1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
signalregulated	GeneRIF Biological Term Annotations	1.0	null
BRD-K26232524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06962
mononuclear phagocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.129596
K562_Trametinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0437846
cdx2_21074721_jejunum_epithelium_lof_mouse_gpl10773_gse23436	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.092899
bladder carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.192031
Prostate adenocarcinoma_PRAD_TCGA-G9-6348-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-38-4625-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A5KG-01A-11R-A27V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
NUGC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01018
male infertility	MGI Mouse Phenotype Associations 2023	1.0	null
monoatomic cation transmembrane transporter activity	GO Molecular Function Annotations 2025	1.0	null
Acute Gvh Disease	DisGeNET Gene-Disease Associations	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
megakaryoblast	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
TUT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.15192
GTEX-T6MN-0008-SM-4DM7H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21763
GTEX-OXRO-0226-SM-3LK6F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900091
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889537
NFE2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9158
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E8-11A-12R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1827	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
RIC8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35028
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
X-linked monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
PMC7726486-mmc3.xlsx-Sheet1-Table_S2_Differentially_expressed_genes_in_ZFP-VPR-362_samples_ZKSCAN7	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-13_CD7_CD1a-_L-IC_DEG-DEG_L2FC_1_0_FDR_0_05_REL	Rummagene Transcription Factor Associations 2026	1.0	null
Primary somatosensory area, barrel field, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1636
Overweight Or Obesity	DisGeNET Gene-Phenotype Associations	1.0	null
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.435
Superior mesenteric artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.531
Astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.176
CHML	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26028
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
metabotropic	GeneRIF Biological Term Annotations	1.0	null
BRD-K11925125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38016
CBX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.33491
BRD-K10211218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43877
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
Bronchial smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.984
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11436
Plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CHMP4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22219
benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042461
RASGRP2	Pathway Commons Protein-Protein Interactions	1.0	null
response to oxygen-containing compound	GO Biological Process Annotations 2015	1.0	null
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.37782
AIF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9415
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYL2	Pathway Commons Protein-Protein Interactions	1.0	null
BT-549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03014
PMC12478325-12672_2025_3468_MOESM1_ESM.xlsx-Table_S9-Table_S9_Results_of_MR_analysis_between_druggable_genes_eQTLs_and_CrNEN_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
insemination	GO Biological Process Annotations 2015	1.0	null
vicinity	GeneRIF Biological Term Annotations	1.0	null
GSE242333_0_v_2_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.00105
GSE155695,GSE155696_1_v_0_acetaminophen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ion channel activity	GO Molecular Function Annotations 2015	1.0	null
GSE120200,GSE127269_1_v_2_asxl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GPR20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37241
response to organic substance	GO Biological Process Annotations 2015	1.0	null
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.955007
Prostate adenocarcinoma_PRAD_TCGA-HC-7742-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_SL-327_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0246663
K562_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168857
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.40173
BRD-K27529556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28368
Peritoneal macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.299
SMIM13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12479
K562_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0212121
el2	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.726
CRCGN015_MCF10A.WT.HP_24H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.29269
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K37906761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42914
MAN1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7068
Cell body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.786
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917505
BRD-K35975002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.44939
RMDN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.5973
seed	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.079379
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5003
Agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.649
DMD	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K09721123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28964
peroxisome	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE240439_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SW48	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_PD173074_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0391649
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.289
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
cystitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.932898
K562_Celecoxib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.029027
FKBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46059
BRD-K73524144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.43762
GATA1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bladder wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.59127
Sarcoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.39
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
help	GeneRIF Biological Term Annotations	1.0	null
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.116
neuron part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Pancreatic ductal adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.086365
effect	GeneRIF Biological Term Annotations	1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Tofacitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218397
SNB75	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.844699
LRRC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47499
G protein-coupled GABA receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.732
GP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677135
passive transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Specific granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
FKBP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00732869
GTEX-S4Z8-1726-SM-3K2AX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.976537
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21713
BRD-K30973947	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18432
GATA2	ENCODE Transcription Factor Targets	1.0	null
Platelet homeostasis	Reactome Pathways 2014	1.0	null
transmembrane transport	GO Biological Process Annotations 2015	1.0	null
GSE81193_0_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Bed nuclei of the stria terminalis, anterior division, dorsomedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09973
SPI1	ChEA Transcription Factor Targets	1.0	null
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
vascular bundle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.118381
raft	GeneRIF Biological Term Annotations	1.0	null
BRD-A68175400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18162
GSE159937_2_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56711
GRIN2C	Pathway Commons Protein-Protein Interactions	1.0	null
LNZTA3WT4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ALX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97808
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.97935
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.185307
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09178
H3K27ac_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YN-11A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4112
alpha2aadrenergic	GeneRIF Biological Term Annotations	1.0	null
TNP-ATP	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
K562_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222747
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RAD21-21589869-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BTBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08804
GTEX-R55C-1826-SM-3GADI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3978
TOV-112D	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01018
K562_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0449621
Acute Myeloid Leukemia_LAML_TCGA-AB-2811-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE157960_2_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_Trametinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0423303
GTEX-WHPG-2326-SM-3NMBP	GTEx Tissue Sample Gene Expression Profiles	1.0	2.06797
HT-29	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1254
UBE2Z	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8093
K562_Trametinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0442498
BRD-K53612668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97557
hsa-miR-4802-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
hsa-miR-2355-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Autosomal dominant disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
OPA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53061
BRD-K36271521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06717
meg-01 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.325701
hypertension	MGI Mouse Phenotype Associations 2023	1.0	null
intrinsic component of organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-UJHI-0626-SM-3DB8T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931932
integral component of membrane	GO Cellular Component Annotations 2015	1.0	null
astrocyte projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.281085
r8 part of basomedial reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.64523
stratum oriens of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1223
cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
PMC12318984-Table1.xlsx-S7-Table_S7_Instrumental_variables_IVs_identified_from_eQTL_dataset_for_druggable_GIKs_used_in_Mendelian_randomization_MR_analysis_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_3hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
p2x1erk2myosin	GeneRIF Biological Term Annotations	1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8944
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.12026
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12394
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ITK_knockout_241_GSE12465	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.74195
amplify	GeneRIF Biological Term Annotations	1.0	null
A-498	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.95269
GJB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0051102
BRD-K05118861	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51025
RASSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48746
GTEX-QVUS-0008-SM-447AY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20597
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.63715
mantle zone of r2Tr	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05959
Dentate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49884
Parasympathetic ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.671
r8 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.85712
BRD-K32727528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26749
BRD-K69903198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.12277
BRD-K42453497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.16992
Embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
respiratory system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07114
GSE234340_9_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r8 part of nucleus of Roller	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1746
Schizophrenia	DisGeNET Gene-Disease Associations	1.0	null
Allergic asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.315
UNC13B	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K21743103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09545
Mesenteric artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.765
mobilisation	GeneRIF Biological Term Annotations	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.827
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87993
GSE181003_1_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormal reproductive system physiology	MPO Gene-Phenotype Associations	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
their	GeneRIF Biological Term Annotations	1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829803
BRD-K46560430	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09003
HOP92	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.23213
A2058	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34419
thrombin	GeneRIF Biological Term Annotations	1.0	null
GSE226249_5_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.57771
inorganic cation transmembrane transport	GO Biological Process Annotations 2025	1.0	null
membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
SIVA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29925
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.666402
GTEX-QLQ7-1526-SM-2S1QA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886787
GSE100316_5_v_4_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ETV2::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7131
HNRNPDL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11452
BRD-K68463857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02474
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.979481
Retrosplenial area, lateral agranular part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10312
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16262
SAP30	ENCODE Transcription Factor Targets	1.0	null
SORBS1	Pathway Commons Protein-Protein Interactions	1.0	null
GATA2	ChEA Transcription Factor Targets	1.0	null
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50709
Overactive bladder syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.504
GSE233679_12_v_11_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
glycine-tRNA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.609
ETV2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32814
GXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4317
CPZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39658
GSE217776,GSE217829_4_v_6_sgf29_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UBN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66564
ERAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14922
chain	GeneRIF Biological Term Annotations	1.0	null
immune	GeneRIF Biological Term Annotations	1.0	null
K562_SRT1720 HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0308025
Lung adenocarcinoma_LUAD_TCGA-97-A4M2-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K71824916	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.08999
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11699
TMUB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76253
hypocotyl	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.064219
DUSP16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16347
membrane part	GO Cellular Component Annotations 2015	1.0	null
GTEX-U3ZH-0008-SM-4DXT2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05836
TYKNU	DepMap CRISPR Gene Dependency	1.0	4.51426
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Gandotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181578
GSE225218_8_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
p2x1	GeneRIF Biological Term Annotations	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.13373
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.883807
CCNG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.80764
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7049-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34933
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.573
anion binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K73357447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25264
hsa-let-7f	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
macrophage	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.381755
GSE199255,GSE199356_3_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
recovery	GeneRIF Biological Term Annotations	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.42122
VCAP	DepMap CRISPR Gene Dependency	1.0	2.52963
Mesothelioma_MESO_TCGA-MQ-A6BL-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
adenosine-triphosphate	Phosphosite Textmining Biological Term Annotations	1.0	null
BRD-K59272984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20242
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
SMURF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90719
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.54706
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.232
Ejaculatory duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.959
Motor trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.69
GTEX-OXRN-0011-R10A-SM-2I5GC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10445
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126402_5_v_7_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933073
MM127	DepMap CRISPR Gene Dependency	1.0	2.15252
BRD-K28093873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24948
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.895
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.65868
TBL1X	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.30994
PJVK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61496
nalbuphine-1379	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Rostral ventrolateral medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.212
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-PC-A5DK-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ADAMTS15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6806
BRD-K19693607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2883
CMTM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75634
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K85232515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26337
ML-2	GDSC Cell Line Gene Expression Profiles	1.0	2.42672
sensory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.765711
Pancreas	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.21764
ASH-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
sipa	GeneRIF Biological Term Annotations	1.0	null
GSE199204,GSE211619_4_v_5_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
change	GeneRIF Biological Term Annotations	1.0	null
superficial stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.40775
SOX8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.94505
USF1	ENCODE Transcription Factor Targets	1.0	null
Perturb_5559_KO_Wdr26_SRP212064	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.73526
epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051317
bladder	GTEx Tissue Gene Expression Profiles	1.0	1.15639
GSE244072_10_v_8_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
BRD-K04087396	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1121
DNAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94586
level	GeneRIF Biological Term Annotations	1.0	null
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_3_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Spanning component of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.351
Urethral false passage	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.337
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.376
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.018
BRD-K31462164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63695
BRD-K87268607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22097
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4971-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.10047
BRD-K73427605	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14786
K562_TG101209_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0397893
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.900489
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CBX3	ENCODE Transcription Factor Targets	1.0	null
BRD-K31883758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32748
TMEM43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28682
PMC10933434-44319_2024_69_MOESM1_ESM.xls-HRV16_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
RASGRP1	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Capecitabine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0419703
TBP	ENCODE Transcription Factor Targets	1.0	null
cardiovascular system phenotype	MPO Gene-Phenotype Associations	1.0	null
thioridazine-422	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
intrinsic component of organelle membrane	GO Cellular Component Annotations 2015	1.0	null
MOLP-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.963614
Embryonic kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.761
hsa-miR-345	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
PCDHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17975
shoot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.384766
Pontine nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.546
FAM83E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85374
WASHC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38145
BRD-K38035271	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.41368
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.25983
coagulation	GeneRIF Biological Term Annotations	1.0	null
plant form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059788
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_84_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
neuronal action potential	GO Biological Process Annotations 2015	1.0	null
nonfunctional	GeneRIF Biological Term Annotations	1.0	null
ES-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.3855
hsa-miR-4283	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
basal	GeneRIF Biological Term Annotations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:F08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.1575
Platelet dense granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.859
K562_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0161384
Muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PPARGC1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64595
Medullary collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.461852
GTEX-RNOR-0426-SM-2TF4U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59824
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.294
17495134-TableS1	GeneSigDB Published Gene Signatures	1.0	null
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.23584
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EHMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.87654
calcium signaling pathway	KEGG Pathways	1.0	null
AT6.1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.612
Blood plasma	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Nucleus accumbens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.208
neuron projection	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.083029
BRD-K81082554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22103
FLI1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Cerebral artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.496
serotonin-activated cation-selective channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.286
showed	GeneRIF Biological Term Annotations	1.0	null
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
single-organism transport	GO Biological Process Annotations 2015	1.0	null
K562_Tranylcypromine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0345788
496100409_FWM_no dementia_TBI_85_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.57664
BRD-K26431593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44078
PMC12822963-pone.0339296.s005.xlsx-Sheet1-HIF1A_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
HDAC3_KO_GDS4886_66_mouse_Heart	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Guanylate cyclase complex, soluble	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.824
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JJ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MLEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60826
positive regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
GSE160304,GSE163392_2_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU1079	CCLE Cell Line Gene CNV Profiles	1.0	1.42456
K562_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0170019
BRD-K77797840	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3262
adenyl ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K90644597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.3216
BRD-K84271229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30961
RPS6KA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.41856
Acute Myeloid Leukemia_LAML_TCGA-AB-3005-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BT12	DepMap CRISPR Gene Dependency	1.0	3.04226
K562_Raltitrexed_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0265091
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
S100A14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95286
ZSCAN9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75402
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.824395
GSE193751_1_v_3_oridonin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPN-2826-SM-3LK67	GTEx Tissue Sample Gene Expression Profiles	1.0	0.977675
membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.02181
r2 part of trigeminal sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.06385
TPCN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.185
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.964683
KDM2B-26808549-CHIP-SEQ-SIL-ALL-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
RCBTB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33828
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.46
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_21_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K03309398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43718
Lung adenocarcinoma_LUAD_TCGA-97-A4M1-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mantle zone of the IG	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84641
C2BBE1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.26598
Occlusion precerebral artery	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
RL7	BioGPS Cell Line Gene Expression Profiles	1.0	0.97306
BRD-K70057550	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95725
ZNF611	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27981
adult	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.328628
GTEX-QDT8-0426-SM-32PKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71974
SNU-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.64501
aggregation	GeneRIF Biological Term Annotations	1.0	null
GSE124471,GSE124488_1_v_0_lats1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
required	GeneRIF Biological Term Annotations	1.0	null
H3K9me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Trigeminal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.839
GSE218060_5_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE223008_9_v_8_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Corpus cavernosum smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.238
Lung adenocarcinoma_LUAD_TCGA-91-A4BC-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213410_2_v_3_calcitriol_human	RummaGEO Drug Perturbation Signatures	1.0	null
Astrocyte projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.22
BRD-K56889360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3357
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
GSE180200,GSE180201_5_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lateral reticular nucleus, magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.56711
HPAC	CCLE Cell Line Gene Expression Profiles	-1.0	-3.38296
BRD-K13110695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16966
496100539_HIP_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02885
BRD-K38557728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01517
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_WHI-P154_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0260881
regulation of programmed cell death	GO Biological Process Annotations 2015	1.0	null
BzATP	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
hsa-let-7a	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
NSUN7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49516
PMC9714459-DataSheet3.xlsx-Supplement_3A-1037_elements_included_exclusively_in_MSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
KMS21BM	CCLE Cell Line Gene Expression Profiles	1.0	1.66433
ESRRA_01_280	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60744
paraterete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33882
Uterus	GTEx Tissue Gene Expression Profiles 2023	1.0	1.17791
JK1	CCLE Cell Line Gene Expression Profiles	1.0	1.42031
Nr1h4	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.6197
BRD-K57795803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34251
GATA2_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.45797
BRD-K86884344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30605
TLR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43092
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.356
spinal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.02118
PPP1R16A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64018
contributed	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-1203	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
MEIOB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14226
rhombomere 9	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11807
chemotaxis	GeneRIF Biological Term Annotations	1.0	null
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02099
TMTC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07501
hsa-miR-3190	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
PYCR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1783
acts	GeneRIF Biological Term Annotations	1.0	null
Allergic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.587
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_0_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
embryonic kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.64529
GSE225982_1_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	1.0	null
TE15	CCLE Cell Line Gene CNV Profiles	1.0	1.47863
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	1.0	1.45293
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GK-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72111
MYC_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210580_5_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91137832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18102
H3K4me1_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.24575
hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.233162
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.821797
K562_TGX-221_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213691
interstitial cystitis	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.14517
intracellular organelle part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04042
CHD1	ENCODE Transcription Factor Targets	1.0	null
C1QTNF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06698
Postsynaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.319
BRD-K33200274	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75396
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.16004
trigeminal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.860521
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.09783
Respiratory smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.171
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-OOBJ-0008-SM-3NB26	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26829
Peripheral nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.205
propidium iodide-6104	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
single-multicellular organism process	GO Biological Process Annotations 2015	1.0	null
SOX3-22085726-NPCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WYJK-0426-SM-3NM9G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25825
GTEX-QV44-2226-SM-447A3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40803
contraction	GeneRIF Biological Term Annotations	1.0	null
GTEX-NFK9-0526-SM-2YUNL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27734
fat_8a	HPA Tissue Sample Gene Expression Profiles	1.0	0.993657
Bone resorption disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
aorta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.329361
BRD-K96845170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1969
Brain Lower Grade Glioma_LGG_TCGA-HT-7608-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE173873_12_v_13_stra8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_MK-0752_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182193
BRD-K52123140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55333
H3K9ac_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-4306	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7671
BRD-K90999585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28938
Rectum adenocarcinoma_READ_TCGA-AG-3732-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
RXYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92334
GPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80735
release	GeneRIF Biological Term Annotations	1.0	null
motor trigeminal nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.542963
K562_WP1066_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0352478
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.04495
atp binding	GO Molecular Function Annotations 2015	1.0	null
NOP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03072
HBA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506151
Cul2-RING ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.625
SCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93853
GTEX-P44H-0008-SM-48TDW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20258
hematopoietic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070761
TAPBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29185
MMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56132
GTEX-WYBS-0426-SM-3NM9M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67564
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST18-Unnamed_2_ST18	Rummagene Transcription Factor Associations 2026	1.0	null
PMC5725737-IJC-142-297-s013.xlsx-DTC_mna_vs_TUM_mna-DTC_MYCN-high_vs_TU_MYCN-high_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
Microglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.238
Sexual dysfunction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
N-11 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.666
t67-small-intestine_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	1.31718
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.791
olfactory lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.221521
BRD-K43468685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09193
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
SNU738	CCLE Cell Line Gene CNV Profiles	1.0	2.00139
Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW156	DepMap CRISPR Gene Dependency	1.0	4.30374
MROH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85387
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.319328
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.807
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.41939
early	GeneRIF Biological Term Annotations	1.0	null
Radiation cystitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
r8 part of basolateral reticular formation	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49476
H3K4me1_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CEP120	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65086
Uroepithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.879
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.324
K562_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0246734
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25881
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892056
ATF1	ENCODE Transcription Factor Targets	1.0	null
TMEM216	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66677
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_24_human_DRSG_higherRes-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Rheumatoid arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.65
BRD-K82521348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38655
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36304
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.384
PMC7578381__F6	PFOCR Pathway Figure Associations 2024	1.0	null
MFE-280	GDSC Cell Line Gene Expression Profiles	-1.0	-1.44934
BRD-K35049668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31301
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.73
STYXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93348
BRD-K91216645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71639
496100608_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.53289
PMC6694122-41467_2019_11591_MOESM7_ESM.xlsx-f_CEBPA_DEGs-Gene_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF608	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99953
C1orf109	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20626
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_0_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC13127299-mmc2.xlsx-PBX1_kdRNAseq-hgnc_symbol_PBX1	Rummagene Transcription Factor Associations 2026	1.0	null
transient	GeneRIF Biological Term Annotations	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.555
CRCGN017_MCF10A.WT.HP_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15132
BRD-K58333451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43465
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04047
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.25912
PKP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85391
membrane lipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-5_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
ion transport	GO Biological Process Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-L9-A444-01A-21R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0415802
ACP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00500502
coagulating gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.324605
PMC7889611-41467_2021_21346_MOESM10_ESM.xlsx-High_TSA_score_correlations-Supplementary_Data_6_Genes_with_expression_that_positively_correlate_with_a_high_TSA_score_in_AIRE_and_corneocyte-like_mTECs_AIRE	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234340_1_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SLC4A1AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99603
K562_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0177195
BRD-K78697404	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96464
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.282
Perturb_13400_KD_PBX1_SRP302267	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.44296
K562_Altretamine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154904
abnormal litter size	MPO Gene-Phenotype Associations	1.0	null
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GSE216043_10_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SUB1_02_117	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.85798
K562_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.025535
hsa-miR-3938	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
NR2C2AP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.19271
BFSP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063108
GSE218060_7_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE81193_3_v_5_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
THOC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11415
K562_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.024827
H3K4me1_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
1321-N1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.196
YJEFN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32478
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.60046
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-4_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WFG7-0008-SM-4LMKB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
Encephalomyelitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.503
small molecule binding	GO Molecular Function Annotations 2015	1.0	null
OAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75812
GSE147210_3_v_4_kmt2d_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129241_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H1155	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.912176
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.651111
Perturb_14529_KO_Gata4/Nr5a2_SRP111204	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.669
BRD-K37271110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08732
SLC17A7	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0272418
BRD-A94413429_NTNCB hydrochloride_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K43473008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04173
GTEX-PWOO-2426-SM-2S1OV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03342
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.50484
SPI1-23547873-NB4-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
TFAP2C	ENCODE Transcription Factor Targets	1.0	null
substrate-specific transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
BRD-K55505527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.49136
PMC12978397-wjon-17-02-247-s002.xlsx-S2-Suppl_2_Two-sample_MR_analysis_of_blood_eQTLs_associated_with_LUAD_P_0_05_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE234340_10_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214596,GSE214598_1_v_2_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
plasma membrane	LOCATE Predicted Protein Localization Annotations	1.0	null
Perturb_2948_KD_Hnrnpk_DRP004738	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.9923
LBP-1	MotifMap Predicted Transcription Factor Targets	1.0	null
CRCGN015_MCF10A.TP53.M_24H:A05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42089
PLEKHO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64746
positive regulation of ion transport	GO Biological Process Annotations 2015	1.0	null
BRD-K97805186	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11917
Multiple sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.858
NCIH2066	CCLE Cell Line Gene CNV Profiles	1.0	2.19019
K562_BMS-265246_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204329
nerve	GeneRIF Biological Term Annotations	1.0	null
15459216-TableA2a	GeneSigDB Published Gene Signatures	1.0	null
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular component organization	GO Biological Process Annotations 2015	1.0	null
arsenic trioxide_homo sapiens_gpl201_gse48441	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE233679_5_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9288051-13046_2022_2428_MOESM6_ESM.xlsx-Super_enhancers_in_B-ALL3-OVERLAP_GENES_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
BMMC cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.965
suggests	GeneRIF Biological Term Annotations	1.0	null
K562_CEP-33779_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0580047
K562_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0296427
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K68257399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43677
connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042293
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.7
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9792
mediodorsal nucleus of thalamus_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.931704
GSE150049_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_4_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0405643
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.33744
GSE180200,GSE180201_12_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
STX1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22435
SLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38048
nb41a3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.541
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.21263
BRD-K07460436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14903
LRRC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24969
gemfibrozil-2277	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_Tie2 kinase inhibitor_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215664
male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.226262
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2067
Carotid sinus nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.356
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RABL2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25272
GTEX-X5EB-2626-SM-4E3HZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44112
BRD-K46603043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97661
lateral subdivision of BNST	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.6271
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.561358
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949377
H2AC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07012
K562_Tie2 kinase inhibitor_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169159
RBBP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77478
UBTF	ENCODE Transcription Factor Targets	1.0	null
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.873577
thiostrepton-2462	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K87418410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05985
GSE149035_3_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
regulation of ion transport	GO Biological Process Annotations 2015	1.0	null
CRCGN015_HEPG2_48H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17457
PAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28707
exocrine acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.146447
TNIK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12203
mediates	GeneRIF Biological Term Annotations	1.0	null
foxa2_20483781_p15_lung_lof_mouse_gpl1261_gse19204	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.068858
GTEX-SIU8-0426-SM-4BRUE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11619
TF1	CCLE Cell Line Gene Expression Profiles	1.0	1.39369
GSE120612_6_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Varicosity	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.373
GSE89767_6_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3967
superficial stratum of RtC	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10135
BRD-K77713205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99831
SNU886	CCLE Cell Line Gene CNV Profiles	-1.0	-1.60044
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76109
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09453
Oligodendrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.695
spanning component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.739614
LBHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06122
vein	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.221989
K562_Ruxolitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199611
GTEX-OXRK-0008-SM-3NB28	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16176
BRD-K21678546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30339
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A3CI-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
participate	GeneRIF Biological Term Annotations	1.0	null
Sporozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.916
Contractile vacuole	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.314
zinc ion binding	GO Molecular Function Annotations 2015	1.0	null
HSFX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47124
MYC_Activation - 8 hours_GDS2025_725_mouse_Pancreatic islet beta cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
thymus	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.959223
medial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.83615
corpus callosum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17287
K562_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0236553
protein homooligomerization	GO Biological Process Annotations 2015	1.0	null
BRD-K22475995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.13559
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.43414
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.825419
conclusion	GeneRIF Biological Term Annotations	1.0	null
TIMP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54604
Lung squamous cell carcinoma_LUSC_TCGA-34-8454-11A-01R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE86021_1_v_3_crenolanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
detected	GeneRIF Biological Term Annotations	1.0	null
PMC6366099-13075_2019_1825_MOESM8_ESM.xls-LPS-regulated-sites_txt-Gene_Name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FOXO1::ELK3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7118
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_18_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Megakaryoblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.707
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07944
K562_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020788
cellular component assembly	GO Biological Process Annotations 2015	1.0	null
monoatomic ion channel activity	GO Molecular Function Annotations 2025	1.0	null
BRD-K84541452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22167
AP-4	MotifMap Predicted Transcription Factor Targets	1.0	null
K562_Daphnetin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0207217
GTEX-RU1J-0008-SM-46MV9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14517
Vibrissa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.925
loss	GeneRIF Biological Term Annotations	1.0	null
GTEX-U8XE-0626-SM-3DB8U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49372
GTEX-PLZ4-0008-SM-48TE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10963
Perturb_13399_KD_PBX1_SRP302267	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.2113
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.779
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-2_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
ZHX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20489
FREY1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22373
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70513
microbody	LOCATE Predicted Protein Localization Annotations	1.0	null
GCLC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37569
Salivary gland epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.588
BRD-K33997327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13553
K562_Anacardic Acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0301597
CDA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55352
urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BIPHOSPHONATE	DGIdb Drug Targets 2026	1.0	1.37486
NFATC3	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-DX-A48O-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YR-11A-13R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KDM6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48368
KCTD17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91449
MTHFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11315
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K67950754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.98849
ZNF768	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74425
pregnant	GeneRIF Biological Term Annotations	1.0	null
Stomach smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.964
transmembrane	GeneRIF Biological Term Annotations	1.0	null
hsa-let-7c	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
BAG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59293
GSE195559_0_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.24387
BRD-K83475223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42507
thymocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.253578
Scott syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
Autosomal Recessive Polycystic Kidney Disease	DisGeNET Gene-Disease Associations	1.0	null
Cochlear ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.018
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF181	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79159
Lung adenocarcinoma_LUAD_TCGA-38-4626-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
blood vessel endothelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.571219
purinergic receptor activity	GO Molecular Function Annotations 2015	1.0	null
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
FAM76B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57997
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
REST_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08399
whereas	GeneRIF Biological Term Annotations	1.0	null
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.302
secreted	GeneRIF Biological Term Annotations	1.0	null
pancreatic adenocarcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.097085
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.874595
Anterior cingulate cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.888
light	GeneRIF Biological Term Annotations	1.0	null
MYOD1_myocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ITGB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43173
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_AZ 960_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.022979
EBF1	ENCODE Transcription Factor Targets	1.0	null
P2RX2	Pathway Commons Protein-Protein Interactions	1.0	null
ZBTB24	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.7319
K562_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182062
K562_Bisindolylmaleimide IX_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0386247
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.374618
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
RMGI	CCLE Cell Line Gene CNV Profiles	-1.0	-1.50519
GTEX-Q734-2226-SM-3GAD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47442
K562_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0227282
IOSE80	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.11557
atractyloside-4717	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pulmonary artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.251279
GTEX-XBEW-0008-SM-4AT3Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02996
K562_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210175
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Andarine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0259988
GSE157594_5_v_7_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GATA1-19941827-MEL-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Bounding membrane of organelle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-QV31-0008-SM-447AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22252
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
C6 glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.842
Lung squamous cell carcinoma_LUSC_TCGA-85-8287-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SCN5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42733
kidney_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.824531
integral component of nuclear inner membrane	GO Cellular Component Annotations 2015	1.0	null
metencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.445653
chromaffin cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.286026
BRD-K69922285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41268
GSE123943_2_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE205163,GSE205164_1_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
KRAS.BREAST_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Middle cerebral artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.361
Lung adenocarcinoma_LUAD_TCGA-91-6836-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Secretory granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
TRIM71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16946
due	GeneRIF Biological Term Annotations	1.0	null
Anterior cingulate area, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39436
CD47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32753
BRD-K22694513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34745
G protein-coupled receptor dimeric complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.797
BRD-K80575072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20306
K562_Costunolide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0265797
KPNYS	DepMap CRISPR Gene Dependency	1.0	3.22776
purine ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
r1 part of lateral pontine nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10883
BRD-K89932793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09151
BRD-K56531121	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28129
BRD-K33064128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.88561
Carotid body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.352
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.96769
Acquired immunodeficiency syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
Polycystin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.954
lipid biosynthetic process	GO Biological Process Annotations 2015	1.0	null
PYGM	Pathway Commons Protein-Protein Interactions	1.0	null
staurosporine-508	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Periventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.55179
TAL1_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Septofimbrial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.65776
FAM219A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17767
K562_Cerdulatinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0759782
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.599675
lead	GeneRIF Biological Term Annotations	1.0	null
Connexin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.887
uterus	GeneRIF Biological Term Annotations	1.0	null
TSPAN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599713
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
outer hair cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.299242
PGR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65799
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.60316
A361	BioGPS Cell Line Gene Expression Profiles	1.0	0.857093
K562_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0347826
Chromaffin cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.475
GTEX-PWN1-0008-SM-48TEA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57906
Smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.04
NF279	DGIdb Drug Targets 2026	1.0	4.812
Sarcoma_SARC_TCGA-DX-A48P-01A-11R-A30C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QXCU-0226-SM-2TC5W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.69033
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urinary bladder smooth muscle	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hair	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.104781
nuclear membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
RERF-LC-OK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.912176
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.857954
SLC25A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24839
BRD-K50443235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.74756
K562_Dasatinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.041327
SPCS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26936
K562_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142938
EHF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92793
X-linked recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
Carotid artery occlusion	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
BRD-K13567350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38885
cell periphery	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.567585
atp	GeneRIF Biological Term Annotations	1.0	null
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23216
KG1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46028
CRCGN012_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0941
CHL1DM	DepMap CRISPR Gene Dependency	1.0	2.5954
periventricular stratum of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.41436
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
positive regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
patch-clamp-techniques	Phosphosite Textmining Biological Term Annotations	1.0	null
BCDIN3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.15436
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29193
choroid plexus of the fourth ventricle	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.8927
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S33H-2426-SM-2XCB2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48936
GSE134316_1_v_0_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PCSK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98768
BRD-K00263786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03672
BRD-K04462989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74472
CTNS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72746
promazine-3833	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lateral tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.33262
GSE133516_0_v_1_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0274963
BRD-A32128687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41437
Bed nuclei of the stria terminalis, anterior division, magnocellular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16282
hematopoietic stem cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE110178_4_v_7_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
episupraoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1069
Coronavirus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
amino	GeneRIF Biological Term Annotations	1.0	null
496100596_FWM_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.47805
18801183-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K04704273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75384
DNMT3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80589
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.957694
ATG9B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60037
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Hic1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.946
Prostate adenocarcinoma_PRAD_TCGA-J4-A67R-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-U412-0008-SM-4DXTE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34442
UBE2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.3684
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27987
FANCF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61137
GSE216043_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Inner plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.944
GTEX-XPT6-2226-SM-4B66R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45745
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K83708628	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11661
FAM220A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90492
Perturb_16671_KO_Zfp36l2_SRP310261	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-17.214
MEWO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.20571
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S1-Table_S1_Instrumental_variables_used_in_MR_analysis_of_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
HT55	CCLE Cell Line Gene CNV Profiles	1.0	1.36466
Pancreas-pancreatic acinar cell	Tabula Sapiens Gene-Cell Associations	1.0	12.1015
RBM25_02_119	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	4.16993
Septicemia	DisGeNET Gene-Disease Associations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67O-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Integrin alphaIIb-beta3 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.965
muscle	GeneRIF Biological Term Annotations	1.0	null
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944463
CAMK2B	Pathway Commons Protein-Protein Interactions	1.0	null
AMPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55921
LEUTX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78984
MSX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32543
NLRP1 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.612
MHH-CALL-2	GDSC Cell Line Gene Expression Profiles	1.0	2.77375
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.15
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U8XE-0008-SM-4E3K4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06778
BRD-K54751614	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76433
BRD-K82460510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29253
RMG-I	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.10468
CBFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.01655
BRD-K26079895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61496
FAM174C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46042
side of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.007697
thus	GeneRIF Biological Term Annotations	1.0	null
LRRC55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76515
PMC12634441-41375_2025_2771_MOESM8_ESM.xlsx-ATACseq-Table_S3_Bulk_ATAC-seq_GATA2_vs_control_Only_p-adj_0_05_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
KARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88446
t60-adrenal_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	3.885
GSE121319_1_v_2_gprc5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5431-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LRCH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31677
atp-gated ion channel activity	GO Molecular Function Annotations 2015	1.0	null
external female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.171545
MEIS2_02_30	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.6105
Adenocarcinoma of lung_Lung Tissue_GSE1037	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.55677
intermediate filament cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.136921
HL-60 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.183
KIAA2026	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89814
Main olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31666
Bladder wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.39
thromboxane	GeneRIF Biological Term Annotations	1.0	null
FOXP1	ChEA Transcription Factor Targets	1.0	null
Mucosal mast cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.49251
Detrusor sphincter dyssynergia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.413
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
translocation	GeneRIF Biological Term Annotations	1.0	null
SEPTIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69655
GTEX-TKQ1-0126-SM-33HB3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0147
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66021
NCI-H1573	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.98638
BCAP31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89928
BRD-A47137250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55884
GSE160817_5_v_6_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PWN1-1826-SM-2S1PE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30323
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K65888165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3391
blood coagulation	GO Biological Process Annotations 2015	1.0	null
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
K562_A-366_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153788
ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.191408
Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93Y-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29339
NOMO1	CCLE Cell Line Gene Expression Profiles	1.0	1.37499
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24884
CBLIF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00653276
GTEX-P4QS-0008-SM-48TDY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25795
BRD-K51779559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12995
synergise	GeneRIF Biological Term Annotations	1.0	null
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.521
GDF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81594
Trigeminal nerve disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.141
SLC38A9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.47081
LRSAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98469
Diabetic neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.389
Macula densa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.248
FGFR2_activemutant_59_GSE17916	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.82127
BRD-K70200818	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50186
membrane region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.003506
GSE234340_9_v_7_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_15778_KO_Nmnat2_SRP360949	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.71329
Epilepsy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.862
PET100	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10244
K562_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172385
residues	GeneRIF Biological Term Annotations	1.0	null
urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.191408
hoof	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.36526
CAMK2N2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96251
Obstructive lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.73
irf8_00000000_splenic_cd11bplusgrdash1_hdash2b_gen_background_lof_mouse_gpl6887_gse39228	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.070227
superficial stratum of POH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10609
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K92378241	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.8678
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
desensitization	GeneRIF Biological Term Annotations	1.0	null
GTEX-RM2N-1826-SM-2TF5B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872996
abnormal vas deferens morphology	MPO Gene-Phenotype Associations	1.0	null
K562_AG-490_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0347529
Medulla, motor related	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.41543
K562_AC480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0542917
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K73387470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.60896
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6487-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RAB39A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91678
stimulation	GeneRIF Biological Term Annotations	1.0	null
K562_Thiotepa_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0313769
terminal	GeneRIF Biological Term Annotations	1.0	null
BRD-K13350372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09932
PMC9288051-13046_2022_2428_MOESM6_ESM.xlsx-Super_enhancers_in_B-ALL1-OVERLAP_GENES_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
K562_WHI-P154_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0416236
plasma membrane	GO Cellular Component Annotations 2015	1.0	null
CAPNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05712
RHOB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.06149
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	3.09163
BRD-K94469522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22734
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_6_v_1_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.364139
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BEST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97602
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.533
membrane raft	GO Cellular Component Annotations 2015	1.0	null
K562_SL-327_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016505
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
TTL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41177
RUNX1-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.456
KRAS.300_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
synaptic cleft	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.276304
cell projection part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.41886
Inward rectifying potassium channel	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.275
Tunica media vasorum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
K562_Hesperadin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0500261
REST	ENCODE Transcription Factor Targets	1.0	null
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.73
CRCGN009_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.46502
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.5891
MRPS31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80658
K562_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0433066
K562_Toremifene Citrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165893
parvicellular part of Lat	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.21207
doxorubicin_homo sapiens_gpl550_gds848	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
K562_Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0235148
CPSF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95285
K562_ABT-737_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0256956
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN010_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2208
Cytoplasmic vesicle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
MYRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28008
Tuberculosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
infertility	MPO Gene-Phenotype Associations	1.0	null
PMC7921413-41467_2021_21650_MOESM5_ESM.xlsx-002_DE-CD34_Blasts_AP1_low_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K61505971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.09481
cerebellar cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.02388
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965953
UBE2D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.71303
blood platelet disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.132104
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2174
axis	GeneRIF Biological Term Annotations	1.0	null
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01018
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9385264-NIHMS1828071-supplement-8.xlsx-ESR1-gene_symbol_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135350_3_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uroepithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.856
BRD-K81246784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19912
r2 part of vestibular sensory column	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.04394
ceramide biosynthetic process	GO Biological Process Annotations 2015	1.0	null
NFKBID	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94591
K562_Curcumin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165818
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.05413
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.167609
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CNOT10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.585
outer plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.434906
proliferation	GeneRIF Biological Term Annotations	1.0	null
WFS1_KO_GDS4526_111_mouse_brain	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21713
K562_Cerdulatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197117
BRD-K55679243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62229
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865953
PHLDA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67532
regulation of smooth muscle contraction	GO Biological Process Annotations 2015	1.0	null
Spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.402
K562_SRT1720 HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0742167
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7392-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.17827
decreased male germ cell number	MPO Gene-Phenotype Associations	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947561
OCIAML5	CCLE Cell Line Gene Expression Profiles	1.0	2.51853
stratum pyramidale of rostral CA3	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.885283
transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-TMMY-0008-SM-4DXU3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71307
PRSS53	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96081
inner nuclear layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.433374
low compliance bladder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.22432
Cell trailing edge	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.954
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
Perturb_4499_KO_Cftr_SRP067491	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
K562_Costunolide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219969
CRCGN017_MCF10A.WT.HP_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07294
hsa-miR-4755-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Posterodorsal preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.24407
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_MK-0752_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0295506
PMC10933434-44319_2024_69_MOESM2_ESM.xls-HRV16-UV_vs_MI-Ensembl_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052281
GSE126402_2_v_7_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Cardiovascular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
lateral part of r8B	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60903
BRD-K31336762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33543
gut	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.073614
Chloride channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.169
PMC11258892-NIHMS2003533-supplement-MMC6.pdf-35-ZNF587_ZNF587	Rummagene Transcription Factor Associations 2026	1.0	null
MAN2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45807
CTCF-21964334-CHIP-SEQ-BCELLS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
myeloid progenitor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.162506
Cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Nr5a2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.227
azoospermia	MGI Mouse Phenotype Associations 2023	1.0	null
GSE131649_2_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RT112	CCLE Cell Line Gene CNV Profiles	-1.0	-1.52031
intrinsic component of membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
WDR4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.99665
PMC11953390-41598_2025_94761_MOESM1_ESM.xlsx-Table_S3-Table_S3_The_result_of_MR_analysis_and_sensitivity_analysis_for_CKD_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K87167435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40104
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
tolbutamide-2359	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TAF15_02_106	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.58496
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18568
Catecholaminergic neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.519
GSE163809_1_v_2_sdhaf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4026482-pone.0097702.s010.xlsx-LPS_1_8FC_12hour-Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Megakaryocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.44
induced	GeneRIF Biological Term Annotations	1.0	null
male infertility	MPO Gene-Phenotype Associations	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.958065
GSE81193_3_v_2_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
nfkappab	GeneRIF Biological Term Annotations	1.0	null
THAP7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69719
preoptic alar plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46469
brain_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.30184
ASH3	DepMap CRISPR Gene Dependency	1.0	3.90699
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K53901855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94166
GSE169697,GSE169725_0_v_5_prrx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K37433647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04931
BRD-A64774838	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14167
r4 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49682
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37361
SF767	DepMap CRISPR Gene Dependency	1.0	2.06433
Prostate adenocarcinoma_PRAD_TCGA-VN-A88L-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
blood clot	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.523194
txa2	GeneRIF Biological Term Annotations	1.0	null
BMT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77752
GATA1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K36575476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34606
BRD-K52136059	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36087
hindbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.535833
MCF7	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.887531
side of membrane	GO Cellular Component Annotations 2015	1.0	null
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
purine ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
16151515-TableS2	GeneSigDB Published Gene Signatures	1.0	null
r2 part of principal trigeminal sensory nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36981
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.60813
platelet dense granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.740965
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.963261
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skeletal Muscle Female	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.958924
BRD-K18709210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00197
BRD-K29547381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45662
ionotropic	GeneRIF Biological Term Annotations	1.0	null
blood	GeneRIF Biological Term Annotations	1.0	null
response to organophosphorus	GO Biological Process Annotations 2015	1.0	null
nucleoside phosphate binding	GO Molecular Function Annotations 2015	1.0	null
POU1F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83437
PXN	Pathway Commons Protein-Protein Interactions	1.0	null
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00018
K562_Clevudine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0334227
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.22699
K562_PCI-34051_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0206501
antagonists	GeneRIF Biological Term Annotations	1.0	null
hsa-miR-4300	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
BRD-K12833024	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08879
GTEX-XXEK-0008-SM-4BRW7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880659
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QW-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
p1 portion of the paranigral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.37575
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5971-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZW-06A-12R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE160817_2_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.09724
TSPAN31	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72143
K562_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0254708
EFHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62874
GSE115363_2_v_0_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_6968_KD_Dnmt3a_SRP075146	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.578
GATA1	ChEA Transcription Factor Targets	1.0	null
IRS4_KO_GDS1219_306_mouse_brown preadipocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	2.88009
Postsubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.23609
H4C13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79487
hsa-miR-920	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
DDHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77711
ligand-gated monoatomic cation channel activity	GO Molecular Function Annotations 2023	1.0	null
N-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.923
GSE155567_3_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Multiple Sclerosis	DisGeNET Gene-Disease Associations	1.0	null
GPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45414
ROCK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39457
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36085
GTEX-WYVS-2526-SM-3NMAT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58872
regulating	GeneRIF Biological Term Annotations	1.0	null
neuron projection	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.501476
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.868286
brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.663149
ZNF197	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22453
CEBPB-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE162623_0_v_1_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
periventricular stratum of r5Ve	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07697
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2728
GTEX-QEL4-0008-SM-447AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65025
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
GSE150665,GSE150667_1_v_8_mysm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HDAC1	ENCODE Transcription Factor Targets	1.0	null
Nerve trunk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.564
mantle zone of PO1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34501
H3K4me1_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
UBTF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1852
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.01331
IQSEC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63768
K562_Tucidinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179194
BRD-K36651002	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02379
IP5I	DGIdb Drug Targets 2026	1.0	4.812
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RS411	CCLE Cell Line Gene Expression Profiles	1.0	1.577
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
ERF::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8321
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
participation	GeneRIF Biological Term Annotations	1.0	null
ammonium transport	GO Biological Process Annotations 2015	1.0	null
Adenocarcinoma	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE182680,GSE182683_5_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXD4L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36431
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_57_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
vertebrate muscular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.46635
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05501
K562_SRT3025 HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0305879
Perturb_14265_KO_E2f2_SRP090185	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.73704
BRD-K99447506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0872
MYH6	Pathway Commons Protein-Protein Interactions	1.0	null
K562_JNJ-7706621_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0349102
PMC12712253-12672_2025_4014_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_for_PC_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
TCEAL7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51415
RAD21-21589869-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K51237617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55862
HOXA5	JASPAR Predicted Transcription Factor Targets	1.0	null
RASA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94826
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.3499
cholesterol	GeneRIF Biological Term Annotations	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
phenelzine-2357	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Sarcoma_SARC_TCGA-IF-A4AJ-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.367502
hsa-miR-636	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K01827055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05211
nf1	GeneRIF Biological Term Annotations	1.0	null
regulation of endopeptidase activity	GO Biological Process Annotations 2015	1.0	null
HCC2885	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.28582
GTEX-N7MS-0626-SM-2YUN7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.234
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
strychnine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.29464
tlr21	GeneRIF Biological Term Annotations	1.0	null
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972086
BRD-K57969360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1893
cell projection	GO Cellular Component Annotations 2015	1.0	null
outer CP in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05125
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
K562_Avagacestat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205767
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4169-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrointestinal smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.861
artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.202
K562_AR-42_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0287196
dentate (lateral) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.885095
absent germ cells	MPO Gene-Phenotype Associations	1.0	null
thyroid gland	HPA Tissue Gene Expression Profiles	-1.0	-0.844953
CYTL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.67639
main axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.459203
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879883
K562_Ivosidenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197006
LOUCY	GDSC Cell Line Gene Expression Profiles	1.0	1.72193
Pain	DisGeNET Gene-Phenotype Associations	1.0	null
GSE150665,GSE150667_4_v_8_mysm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
r9 basal plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.89938
Cardiac Arrhythmia	DisGeNET Gene-Phenotype Associations	1.0	null
Cortical amygdaloid nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
DCTN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.999
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.0466
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00811
PMC6172843-13059_2018_1523_MOESM6_ESM.xls-Sheet1-Table_S5_mRNAs_variation_abundance_1_5-fold_in_YBX1-knockdown_BGC-823_cells_YBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Carotid artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.451
Neuronal cell body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.238
OTUD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3895
microvessels	GeneRIF Biological Term Annotations	1.0	null
CRCGN011_HEPG2_24H:C02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7512
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954771
forelimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066254
BTBD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47552
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.052027
FTSJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06946
GSE101336_1_v_3_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
dorsal thalamus_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.926056
GSE190534,GSE190536_0_v_1_cyclophosphamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SMAD2/3-21741376-ESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
TAF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K76904668	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3335
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.929
rhombomere 7	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2746
MYT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48346
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-O5YW-1826-SM-2YUN2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33163
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.35901
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.99923
K562_Baricitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197419
BRD-K73459389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01859
THP1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76773
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.01128
BRD-K46291400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01474
conclude	GeneRIF Biological Term Annotations	1.0	null
PMC6117931-12864_2018_5033_MOESM3_ESM.xlsx-Fay_Thermoneutral_LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
calcium ion transport	GO Biological Process Annotations 2025	1.0	null
SNPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5406
vibrissa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.261964
stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.382884
Enteric nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.321
K562_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0676685
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04634
acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.235964
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55791
MDA-MB-435S cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
MYL6	Pathway Commons Protein-Protein Interactions	1.0	null
Endothelial Dysfunction	DisGeNET Gene-Phenotype Associations	1.0	null
HFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70783
BRD-K87689816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9484
GTEX-XGQ4-0626-SM-4AT56	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02973
BRD-K91654198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38175
HOXC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5436
HEP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03014
BRD-K52731672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33129
hymecromone-4623	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
preoptic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.56973
CD33+_Myeloid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.86703
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mean platelet volume	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.952288
NR2C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.9349
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.5718
AGFG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5213
PPP1R8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23604
proportion	GeneRIF Biological Term Annotations	1.0	null
ANKMY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75607
BRD-K37698302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16746
prostate	HPA Tissue Protein Expression Profiles	1.0	1.61878
superficial stratum of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78831
BRD-K32893898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84458
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903521
GSE153124_4_v_0_dsg2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
OGG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41114
KP-N-YN	GDSC Cell Line Gene Expression Profiles	-1.0	-1.56585
AKAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36703
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.511
CIITA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85308
inorganic ion transmembrane transport	GO Biological Process Annotations 2015	1.0	null
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.967603
GSE100316_0_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U4B1-1226-SM-4DXT7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1621
ADSL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31863
LMOD1	Pathway Commons Protein-Protein Interactions	1.0	null
pre-t-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.250953
parafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.49207
OB glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.4271
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A3F2-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2321
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
coordinating	GeneRIF Biological Term Annotations	1.0	null
A4-Fuk	GDSC Cell Line Gene Expression Profiles	1.0	1.94538
Status Epilepticus	DisGeNET Gene-Disease Associations	1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19347
zymogen activation	GO Biological Process Annotations 2015	1.0	null
cation transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00105
BRD-K95323755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36625
G protein-coupled receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.971
Leukocyte disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.187
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11305
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.25604
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE231745_1_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
diflunisal-1990	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ETV5::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6288
BRD3OS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63027
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.576415
BRD-K42769174	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7137
Atherosclerosis	DisGeNET Gene-Disease Associations	1.0	null
RPMI-8226 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.741
regulation of synaptic vesicle exocytosis	SynGO Synaptic Gene Annotations	1.0	null
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39856
secretory granule membrane	GO Cellular Component Annotations 2023	1.0	null
1321-n1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.16116
NAP1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64736
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Trigeminal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.996
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
blood cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061844
Ip<sub>5</sub>I	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
CRCGN012_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02555
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
contributes	GeneRIF Biological Term Annotations	1.0	null
NCI-H1666	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1254
BRD-K48845054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46311
cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.434524
glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.264077
rhombomere 8	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.66565
Trophozoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.059
Kidney Chromophobe_KICH_TCGA-KN-8437-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.111284
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903227
BRD-K48046422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19633
nr4a1	GeneRIF Biological Term Annotations	1.0	null
RASGRF2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PWCY-2226-SM-2S1OP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79704
testis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.58184
GTEX-XOTO-0426-SM-4B66A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92255
lateral septal nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.691
tetraethylenepentamine-574	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC10842785-NIHMS1948219-supplement-3.xlsx-GATA1_sense_vs_antisense-Gene_GATA1	Rummagene Transcription Factor Associations 2026	1.0	null
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.457
regulation of hydrolase activity	GO Biological Process Annotations 2015	1.0	null
mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.218186
Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23572
SREK1IP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11414
GSE165682_2_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE230263,GSE230265_3_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
OB olfactory fiber layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14882
BPGM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7948
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830488
K562_PF-573228_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0295198
cellular process	GO Biological Process Annotations 2015	1.0	null
GSE226983_1_v_0_ddx5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CALU6	CCLE Cell Line Gene CNV Profiles	1.0	1.48204
hek293-cells	Phosphosite Textmining Biological Term Annotations	1.0	null
PMC7578381__F6	PFOCR Pathway Figure Associations 2023	1.0	null
acute myeloid leukemia cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101621
GTEX-OXRO-1926-SM-2S1O3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986265
Perturb_15551_KO_Tug1_SRP176442	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.74069
BRD-K30467307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05032
PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_3_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OOBJ-2626-SM-2I3F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864434
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A497-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cho-k1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.218613
Macroglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.171
cardiac muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.330094
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A7Q1-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.951
GATA4_KO_GDS3486_483_mouse_jejunum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
demonstrate	GeneRIF Biological Term Annotations	1.0	null
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54504
BRD-K14309706	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.12769
intrinsic component of membrane	GO Cellular Component Annotations 2015	1.0	null
novobiocin-na	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.722
CPD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6794
regulation of tube size	GO Biological Process Annotations 2015	1.0	null
GSE236072,GSE236075_2_v_1_ccr6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	5.25004
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
Lupus erythematosus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
K562_2-Methoxyestradiol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0276342
BRD-K93484038	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09775
Rectum adenocarcinoma_READ_TCGA-AF-2692-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
pre-T-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.325
K562_Bisindolylmaleimide IX_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175153
CHD4_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142232,GSE142234_0_v_2_gcgr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.579
VTI1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94082
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65741
Neurogenic bladder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.929
RUNX1-17652178-JURKAT-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
positive regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
dorsal endopiriform nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06052
BRD-K11307720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76362
TIA1_KO_GSE54418_267_mouse_spinal cord	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
membrane region	GO Cellular Component Annotations 2015	1.0	null
superficial stratum of PSPa	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07159
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.891
NCIH1385	CCLE Cell Line Gene CNV Profiles	1.0	1.48049
membrane region	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.108009
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0885
UTX-26944678-CHIP-SEQ-JUKART-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A25184723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65305
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NKX6-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76716
ventrolateral prefrontal cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10538
cochlear ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297806
hematopoietic cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
WBP1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95475
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978349
ligand	GeneRIF Biological Term Annotations	1.0	null
BRD-K81501934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15644
BRD-K80602847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.185
Perturb_8991_KD_EGR2_SRP407074	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.7504
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CMTM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01934
SRRM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.74395
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4114-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-W5WG-0008-SM-4KL25	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3157
CRYZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20985
DAZAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89667
Substance abuse	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.115
H3K4me1_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
external side of cell outer membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Prostate adenocarcinoma_PRAD_TCGA-EJ-7115-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HDAC2_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Transfusion-Related Acute Lung Injury	DisGeNET Gene-Disease Associations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01595
superficial stratum of r1BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10805
NFIC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63357
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HZ-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14413
T3M3	DepMap CRISPR Gene Dependency	1.0	7.51287
GTEX-QEL4-0526-SM-3GIJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34568
LRP8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90208
PUR1	MotifMap Predicted Transcription Factor Targets	1.0	null
K562_XAV-939_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0218767
KDM5B	ENCODE Transcription Factor Targets	1.0	null
nuclear membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.3429
K562_Ruxolitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0237812
ZNF333	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19761
Midbrain central gray	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.166
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.05069
CD19+_BCells(neg._sel.)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.880008
erk2	GeneRIF Biological Term Annotations	1.0	null
Amoeboid microglia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.005
membrane	Phosphosite Textmining Biological Term Annotations	1.0	null
collecting duct	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.118241
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-3_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lateral spinothalamic tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.67
RAD21	ENCODE Transcription Factor Targets	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.988061
cellular component organization or biogenesis	GO Biological Process Annotations 2015	1.0	null
SSR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65482
triphosphate	GeneRIF Biological Term Annotations	1.0	null
Perturb_12993_KO_Il1rl1_SRP274117	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.9126
GTEX-XOTO-0008-SM-4GICE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67559
BRD-K43936610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68338
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05441
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4355-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201309_5_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
COX7A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40733
H2BC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.89201
priming	GeneRIF Biological Term Annotations	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-M7-A723-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF263_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-OHPM-1826-SM-2YUNF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2515
H3K4me1_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5022-01A-21R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIM	Pathway Commons Protein-Protein Interactions	1.0	null
MYBPC1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE129811_5_v_0_niacin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NFATC1	Pathway Commons Protein-Protein Interactions	1.0	null
monoatomic ion channel activity	GO Molecular Function Annotations 2023	1.0	null
BRD-K97410356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17998
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.934
multi-organism process	GO Biological Process Annotations 2015	1.0	null
COMMD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37789
SNU1214	CCLE Cell Line Gene Expression Profiles	-1.0	-2.2826
Medial vestibular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.59
MMAC-SF	GDSC Cell Line Gene Expression Profiles	-1.0	-1.51819
TAL1	ENCODE Transcription Factor Targets	1.0	null
Primary somatosensory area, mouth, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.46694
Platelet alpha granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.19
Lung squamous cell carcinoma_LUSC_TCGA-90-A59Q-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
block	GeneRIF Biological Term Annotations	1.0	null
cyclophosphamide_mus musculus_gpl13209_gse27422	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.87558
vomeralnasalorgan.VMO.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.856466
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUP-T1	GDSC Cell Line Gene Expression Profiles	1.0	1.49932
integral component of organelle membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Dengue Fever	DisGeNET Gene-Disease Associations	1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
CRX-20693478-RETINA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC11668092-12884_2024_7077_MOESM1_ESM.xlsx-Table_S2-Table_S2_Full_result_of_MR_estimates_for_the_association_between_druggable_genes_and_HG_based_on_Finngen_study_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Phosphopantothenoylcysteine decarboxylase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.047
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7504
calcium channel activity	GO Molecular Function Annotations 2025	1.0	null
HCC-44	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Hoof lamina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.614
regulation of membrane potential	GO Biological Process Annotations 2015	1.0	null
K562_Nilotinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.025008
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.31118
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824487
BRD-K85275903	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33707
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.871329
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911055
regulate	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-8309-11A-01R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.779
BRD-K71871382	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82796
Gap junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.874
organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039813
TPM2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947181
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.204263
GTEX-OXRP-2426-SM-2S1NR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03323
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834807
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6934
Principal sensory nucleus of the trigeminal	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05085
horizontal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.322414
BRD-K53612850	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09815
K562_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0282767
epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.960312
triangular septal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.41595
signal	GeneRIF Biological Term Annotations	1.0	null
ALKBH6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00435
meg01	GeneRIF Biological Term Annotations	1.0	null
BMI1-19503595-MEFSC-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
non-neuronal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.645
MAX_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
bone marrow	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.130638
Central Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
PDGF_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
Azurophil granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.708
damage	GeneRIF Biological Term Annotations	1.0	null
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.903556
GTEX-NL4W-0011-R10A-SM-2I3DY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.890544
subtype	GeneRIF Biological Term Annotations	1.0	null
EMC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01599
MECOM-23826213-KASUMI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GRIN1	Pathway Commons Protein-Protein Interactions	1.0	null
Brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Necrosis	CTD Gene-Disease Associations	1.0	1.12082
GSE115363_2_v_5_esrrb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8476
PMC11118997-12931_2024_2848_MOESM1_ESM.xlsx-Table_S4-Table_S4_The_result_of_MR_analysis_and_sensitivity_analysis_for_IPF_susceptibility_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
trigeminal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.631123
MGAT4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09023
hsa-miR-4505	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
PMC7064149-CAM4-9-2062-s004.xlsx-Table_S5-Table_S5_DEGs_between_low-_and_high-FOXP4-AS1_expression_groups_in_PDAC_tumor_tissues_FOXP4	Rummagene Transcription Factor Associations 2026	1.0	null
TRIM27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77031
BRD-K57084585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.00518
E2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
C20orf96	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51809
olfactory receptor neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.251934
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PLB985	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45498
MPDZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75089
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.870841
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U4B1-0008-SM-4DXUW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
peripheral ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.02031
C11orf96	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17346
PTGR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30306
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966863
organonitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
MVD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40365
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.824
PLD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04502
BRD-K03884263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50177
Venule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.123
MNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72399
K562_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0319932
collageninduced	GeneRIF Biological Term Annotations	1.0	null
cell part	GO Cellular Component Annotations 2015	1.0	null
GSE154767_4_v_5_adam10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Paraventricular hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.19609
cfpac-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.259591
mouth	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.423818
NCIH1648	DepMap CRISPR Gene Dependency	1.0	2.30286
abnormal reproductive system morphology	MPO Gene-Phenotype Associations	1.0	null
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GEMIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39032
irritable bowel syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.185612
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.70065
PMC6850916__F7	PFOCR Pathway Figure Associations 2024	1.0	null
JURKAT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
pancuronium bromide-7329	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAFK	ENCODE Transcription Factor Targets	1.0	null
PMC4782046-supp_30.5.508_TableS2.xlsx-TAL1_UTX-co-bound_genes-Unnamed_4_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
Huntington's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
Perturb_17239_KD_PDCD10_SRP389914	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.7467
MDAMB435S	CCLE Cell Line Gene CNV Profiles	1.0	1.84983
GSE244072_10_v_9_tfeb_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE195559_8_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Potassium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.24
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960281
Peripheral nervous system neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.222
AMMECR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60612
GTEX-P4PQ-0008-SM-48TDX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
GM1600	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.52179
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.233
Immunological synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.339
GATA1_G1E-ER4_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FLI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
K562_YM155_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0257133
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942004
purinergic nucleotide receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WG-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intermediate filament	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.10851
BRD-K09560946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.75004
parvocellular part of the r9LRt	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2369
BRD-K86268010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36339
BMI1-19503595-MEFC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Locus ceruleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.232
nucleus of the inferior collicular brachium, caudal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35606
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.782
K562_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0168017
CRCGN014_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.83865
Myenteric plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.198
Lung adenocarcinoma_LUAD_TCGA-50-6590-01A-12R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
DHODH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05932
C-fiber	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.987
SMC1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24677
KNS-42	COSMIC Cell Line Gene Mutation Profiles	1.0	null
496100497_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.94093
K562_Hesperadin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145197
monoamine transport	GO Biological Process Annotations 2015	1.0	null
Childhood Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
HNRNPD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84097
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.78632
PE/CA-PJ15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.871329
Poisoning	CTD Gene-Disease Associations	1.0	1.03827
Osteopenia	DisGeNET Gene-Disease Associations	1.0	null
H3K27me3_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
retina	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.258917
GSE152432_1_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
&alpha;&beta;-meATP	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
BRD-K41829399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.392
BRD-K41513047	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09757
GATA1_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14635
P68-20966046-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
internal segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.841415
Elevation of cytosolic Ca2+ levels	Reactome Pathways 2014	1.0	null
GTEX-OXRL-1826-SM-2YUMV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10376
FARSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37292
edrophonium chloride-2019	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pancreatic cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067066
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
alterations	GeneRIF Biological Term Annotations	1.0	null
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07217
clathrin-coated vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.357086
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.45004
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7242-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF132	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99372
Methylosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.51
Central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K43789905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53101
K562_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0369727
ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9024
NEPRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1491
ribonucleotide binding	GO Molecular Function Annotations 2015	1.0	null
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	95.4439
BRD-K07624584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94269
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.74802
Perturb_9748_KD_LAMP3_SRP352758	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.58543
synapse part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.2287
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GH-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
rather	GeneRIF Biological Term Annotations	1.0	null
neurofilament	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.173003
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
seminal vesicle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.454126
GSE135350_2_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_1_TRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
PNCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68804
parotid acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.220831
KMS21BM	CCLE Cell Line Gene CNV Profiles	1.0	2.48529
inner SZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20113
synaptic membrane	GO Cellular Component Annotations 2015	1.0	null
glycine	GeneRIF Biological Term Annotations	1.0	null
plasma membrane part	GO Cellular Component Annotations 2015	1.0	null
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.446
CNDP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02148
plant embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063233
germ layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.069615
BRD-K06355852	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04531
Lung adenocarcinoma_LUAD_TCGA-44-2662-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gustatory areas, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28336
bladder	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.698
intermediate stratum of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.49275
SP1	ENCODE Transcription Factor Targets	1.0	null
Mental Depression	DisGeNET Gene-Disease Associations	1.0	null
BRD-K37588779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19782
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.268
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864158
olfactorybulb	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.05144
Detrusor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.501
GTEX-WOFM-0726-SM-3MJF8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825931
XRCC5_02_114	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.80735
P2X purinoreceptor	InterPro Predicted Protein Domain Annotations	1.0	null
plant vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.503533
K562_Tozasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0261749
SP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.922908
GSE92434_1_v_0_ebf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.02425
BRD-K76350099	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46517
hsa-let-7g	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
BRD-A19766589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67896
Platelet count	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.20969
cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.801564
BRD-K13317726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45462
MRPS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73969
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIFLUPERIDOL-2HCL	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6024
hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.586665
Presubiculum, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.36358
GTEX-Q734-0008-SM-48U2I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71902
molecular layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.15172
mantle zone of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.60682
medullary hindbrain (medulla)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55612
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
striohypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08633
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.959827
GTEX-TMMY-1526-SM-4DXST	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1711
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.37
Duchenne muscular dystrophy (DMD)_Extraocular muscle_GSE1472	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.78298
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05462
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26049
ZNF384	ENCODE Transcription Factor Targets	1.0	null
regulation of muscle contraction	GO Biological Process Annotations 2015	1.0	null
BRD-K15291808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01565
KCTD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47706
ZNF320	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03503
496100500_PCx_probable Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.40803
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.923804
peripheral nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.873594
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SYPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88749
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.263722
calcium ion transmembrane transporter activity	GO Molecular Function Annotations 2015	1.0	null
Duodenum Mucosa	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.895472
CALM1	Pathway Commons Protein-Protein Interactions	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
orthogonal array	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.194045
Junctional membrane complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.973
r8 part of lateral reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30613
Inferior olivary complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-3.45751
PMC3728595-srep02327-s1.pdf-1622-ZBTB7B_ZBTB7B	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K44664883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07098
urinary bladder smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.06382
GTEX-V955-1826-SM-4JBIL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915833
BRD-K68202742_trichostatin A_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE160304,GSE163392_7_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	1.0	null
HK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26619
OAW28	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.870342
TAL1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
secretion	GeneRIF Biological Term Annotations	1.0	null
integral component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
K562_CUDC-907_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0189255
K562_Fedratinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204895
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Alvespimycin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0232349
PRKAR2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00586056
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.309
K562_Nilotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0278166
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18053
BRD-K50133846	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76968
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7861-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cell culture	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.415053
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GTEX-S4Q7-0008-SM-3NM8A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16132
CTCF_brain microvascular endothelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cysteine	GeneRIF Biological Term Annotations	1.0	null
K562_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164072
CAMK2G	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-Kasumi-1-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_Kasumi-1_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
metal ion binding	GO Molecular Function Annotations 2015	1.0	null
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846753
K562_Carmofur_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174302
MOLP2	CCLE Cell Line Gene CNV Profiles	1.0	2.18413
Median eminence	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.682
GSE205163,GSE205164_2_v_4_znf808_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JB-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neutrophil extracellular trap	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.558
niflumic acid-5071	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
COL2A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34989
TGFBR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.91576
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sympathetic ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.649
urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hippocampus	HPA Tissue Protein Expression Profiles	1.0	0.911469
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.539
NF449	DGIdb Drug Targets 2026	1.0	4.812
pannexin1	GeneRIF Biological Term Annotations	1.0	null
CRCGN014_HEPG2_3H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.19955
BRD-K51743001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04569
CRCGN015_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1701
NFATC2	Pathway Commons Protein-Protein Interactions	1.0	null
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.692382
Kidney Failure, Acute	DisGeNET Gene-Disease Associations	1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08045
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66481
BRD-K51919278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11873
Smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.342
ADIPOR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00666132
TPM3	Pathway Commons Protein-Protein Interactions	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
FAM91A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63405
PPFIA1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K40745976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11065
Sepsis	DisGeNET Gene-Disease Associations	1.0	null
Urinary tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Urethra	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.777
neuron projection	GO Cellular Component Annotations 2015	1.0	null
GSE245270_2_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-2657-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Modiolus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.008
TTN	Pathway Commons Protein-Protein Interactions	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
Chromaffin granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.688
GSE199034_1_v_2_pirfenidone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
embryonic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.380627
MAP3K14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45406
localization	GeneRIF Biological Term Annotations	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A8YF-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
lower limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02082
Trigeminal neuralgia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.142
inner plexiform layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.62991
KCL22	CCLE Cell Line Gene CNV Profiles	-1.0	-1.75144
gated channel activity	GO Molecular Function Annotations 2015	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03297
activation of cysteine-type endopeptidase activity	GO Biological Process Annotations 2015	1.0	null
BRD-K99100679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36752
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
general	GeneRIF Biological Term Annotations	1.0	null
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.53
MRE11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.95178
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42316
Perturb_6531_KO_C1galt1c1_SRP184497	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
GATA1_megakaryocyte_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of proteolysis	GO Biological Process Annotations 2015	1.0	null
BRD-K24308170	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2174
CCDC47	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54189
readily	GeneRIF Biological Term Annotations	1.0	null
SFT2D3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06281
BRD-K26257310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38754
SNUC5	CCLE Cell Line Gene Expression Profiles	-1.0	-1.66716
KLF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90678
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0240875
SMC3	ENCODE Transcription Factor Targets	1.0	null
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE89018_6_v_14_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K37055068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27799
mantle zone of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.78689
BRD-K45342423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31333
SARS-CoV MA15_Day1-PFU-10^4_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.86311
MINDY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00550552
integral component of plasma membrane	GO Cellular Component Annotations 2015	1.0	null
penis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.153296
preglomerular	GeneRIF Biological Term Annotations	1.0	null
CYSLTR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00567964
acute myeloid leukemia cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.242672
BRD-K26314798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14535
GSE112760,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UJHI-1026-SM-4IHJP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825906
GTEX-OOBJ-0226-SM-2YUMM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05613
BRD-K78400597	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29497
GSE109530,GSE109531_2_v_0_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.64792
PRDM1	JASPAR Predicted Transcription Factor Targets	1.0	null
Cystic fibrosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.306
lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061459
Neurosecretory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.533
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984798
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.621
SDR39U1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52272
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960442
metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-V1D1-0726-SM-4JBH7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.939473
Middle Cerebral Artery Occlusion	DisGeNET Gene-Disease Associations	1.0	null
hlmcs	GeneRIF Biological Term Annotations	1.0	null
OCI-AML2	GDSC Cell Line Gene Expression Profiles	1.0	1.9668
GTPBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39327
Sensory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.156
Perturb_14229_KO_Kdm2b_SRP060647	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.25478
hsa-miR-3689d	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70709
BRD-K06678077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26457
GTEX-VUSH-0008-SM-47JWK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44099
hindlimb	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068155
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.08143
TLN1	Pathway Commons Protein-Protein Interactions	1.0	null
mediodorsal nucleus of thalamus_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00485
RSF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90887
Prostate adenocarcinoma_PRAD_TCGA-J9-A52C-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951015
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.9772
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.904106
NCI-H82	GDSC Cell Line Gene Expression Profiles	-1.0	-1.83345
ZNF579	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60098
ALKBH5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49079
GBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00584818
RBPJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73445
PIAS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78495
BRD-K25525067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.30781
result	GeneRIF Biological Term Annotations	1.0	null
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.95
GTEX-RU1J-1926-SM-2TF6S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35205
BRD-K09875820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19246
Dry eye syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.272
BRD-K86694287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04821
BRD-K02106348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6466
BRD-K55072060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01898
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844236
FSCN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00562766
Trachea-mast cell	Tabula Sapiens Gene-Cell Associations	1.0	0.0676866
intrinsic component of plasma membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GTEX-XMD1-0008-SM-4AT41	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16651
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.781546
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K23535862	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23124
GSE213219_2_v_3_st3gal3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
recycling	GeneRIF Biological Term Annotations	1.0	null
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.994464
RMDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80291
abnormal fertility/fecundity	MPO Gene-Phenotype Associations	1.0	null
Neutrophil degranulation	Reactome Pathways 2024	1.0	null
extracellular ligand-gated ion channel activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-XUJ4-0008-SM-4BOQI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21017
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852872
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hemichannels	GeneRIF Biological Term Annotations	1.0	null
astroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.159773
bounding membrane of organelle	GO Cellular Component Annotations 2023	1.0	null
K562_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202832
Tracheal smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.574
BRD-K60076175	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06792
ARFRP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13016
ACO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37575
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.163111
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24593
epinephrine	GeneRIF Biological Term Annotations	1.0	null
extracellularly ATP-gated monoatomic cation channel activity	GO Molecular Function Annotations 2025	1.0	null
NCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
layer III of piriform cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.75068
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MY-A5BE-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K03654379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09625
17060636-Table1	GeneSigDB Published Gene Signatures	1.0	null
ZNF276	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92773
P63-26484246-CHIP-SEQ-KERATINOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DDIAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06449
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7UA-06A-32R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A14878925	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89172
K562_Meprednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0235681
K562_AT9283_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0341057
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06133
establishment of localization in cell	GO Biological Process Annotations 2015	1.0	null
K562_Celecoxib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0244277
PSIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90579
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	1.0	1.00968
K562_Hesperadin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0459183
segments	GeneRIF Biological Term Annotations	1.0	null
Perturb_10123_KD_EGR1_SRP009615	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.76096
EmrE multidrug transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.563
MOGGUVW	CCLE Cell Line Gene Expression Profiles	-1.0	-1.81583
platelet activation	GO Biological Process Annotations 2015	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CALD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51855
GSE233679_6_v_2_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Crohn's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.548
Sensory ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.524
fruit	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.139961
GSE110178_4_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
all	GeneRIF Biological Term Annotations	1.0	null
PORCN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02534
p2y12	GeneRIF Biological Term Annotations	1.0	null
K562_ENMD-2076_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0440182
Uterus-vascular associated smooth muscle cell	Tabula Sapiens Gene-Cell Associations	1.0	0.650866
nasal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.290652
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_NVP-BSK805 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0247953
GTEX-X4XX-0008-SM-46MVK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34087
l45	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.13166
K562_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0271433
autonomic nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.297447
CTCF-21964334-BJAB-B-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Adrenal medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.459
RCOR1	ENCODE Transcription Factor Targets	1.0	null
BRD-K89338967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2761
neurofilament cytoskeleton	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.173003
infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.18651
RASGRP4	Pathway Commons Protein-Protein Interactions	1.0	null
bronchoalveolar system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.109214
EFNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96275
ion binding	GO Molecular Function Annotations 2015	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2932-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.598
TRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4896
ZNF285	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40513
CITED2_02_38	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60864
BRD-K69817695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62141
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_81_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GOLGA6L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.68182
laterodorsal subdivision of area 8	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.95535
INPPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6858
lysine	Phosphosite Textmining Biological Term Annotations	1.0	null
EAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14492
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.37109
salivary gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.105547
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LH-01A-21R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GJB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86721
Femoral artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.158
CLNS1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08206
BRD-K60782883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05077
Arteriosclerotic cardiovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.628
MICOS13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90259
BRD-A03940741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.021
C127I cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.662
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846338
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03376
K562_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273724
TEAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79216
MAGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.4132
K562_TMP195_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172795
PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_11_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
COLO680N	CCLE Cell Line Gene CNV Profiles	1.0	1.35694
substrate-specific transporter activity	GO Molecular Function Annotations 2015	1.0	null
K562_Lenalidomide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162448
TAL1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SYT1	Pathway Commons Protein-Protein Interactions	1.0	null
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
paraventricular nucleus, cap part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0306
BRD-K19387722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33319
NFIC_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
channel	GeneRIF Biological Term Annotations	1.0	null
PMC9288051-13046_2022_2428_MOESM12_ESM.xlsx-HL-60-genes_bound_by_LYL1_at_its_promoter_regions_in_AML_cell_line_HL-60_LYL1	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0230478
CEP43	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00600246
GLIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.238
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
shear	GeneRIF Biological Term Annotations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6969-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE132948,GSE132949_0_v_5_msi2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UTY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03709
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
r5 part of parvocellular medial vestibular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07843
Peritubular cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.777
K562_ITSA-1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210223
PLEKHB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48207
GTEX-UTHO-0011-R3A-SM-3GIK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842623
BRD-K45833502	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44262
Bladder	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.291
Corpus cavernosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.304
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.02518
esophagus_5b	HPA Tissue Sample Gene Expression Profiles	1.0	1.21214
Prostate adenocarcinoma_PRAD_TCGA-H9-A6BX-01A-31R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bernard-Soulier syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
augmentation	GeneRIF Biological Term Annotations	1.0	null
NCIH1105	CCLE Cell Line Gene CNV Profiles	1.0	1.43725
organism form	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
UBQLN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.80959
SUM149PT	DepMap CRISPR Gene Dependency	1.0	7.05241
decreased germ cell number	MPO Gene-Phenotype Associations	1.0	null
RAPGEF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95265
nucleus sagulum, superficial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.39852
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10701
induseum griseum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.84839
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormal sperm number	MPO Gene-Phenotype Associations	1.0	null
K562_Droxinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0645338
signal transduction	GO Biological Process Annotations 2015	1.0	null
GATA2-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
WM88	DepMap CRISPR Gene Dependency	1.0	2.27746
umbilical cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.236921
BRD-K88820027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32084
STRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03989
p2y1	GeneRIF Biological Term Annotations	1.0	null
ventrolateral prefrontal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.874113
neurogenic bladder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.59913
NR3C2-34362910-WISTARRAT-HIPPOCAMPUS	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XYKS-0008-SM-4BRW6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923912
GTEX-XUJ4-2826-SM-4BOQ2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940424
BRD-K61134709	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79181
urinary bladder	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.10889
Hepatoma ascites cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.772
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_27_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28704
megakaryocyte	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71895
start	GeneRIF Biological Term Annotations	1.0	null
K562_Lenalidomide_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.01699
pancreas	HPA Tissue Gene Expression Profiles	1.0	0.974143
PMC9288051-13046_2022_2428_MOESM5_ESM.xlsx-Super_enhancers_in_T-ALL3-OVERLAP_GENES_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
GSE180200,GSE180201_2_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IGFBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0311
GTEX-S4Z8-2026-SM-3K2A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21814
leukocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.415053
TMEM222	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56161
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
Primary somatosensory area, unassigned, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6247
p2x7	GeneRIF Biological Term Annotations	1.0	null
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.453
evoked	GeneRIF Biological Term Annotations	1.0	null
pancreas	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23083
ligand-gated channel activity	GO Molecular Function Annotations 2015	1.0	null
PYGL	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K76521932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.42162
FBXO34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85773
FMO5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86776
vascular tissue	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.111143
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60794504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49745
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.66994
STX1A	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100591_TCx_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.27341
GSE137818_5_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
USF1	JASPAR Predicted Transcription Factor Targets	1.0	null
ERBB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5018
BRD-K41887762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56166
SCAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53352
GRAMD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66803
hsa-miR-4505	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Perturb_4670_KO_Pten_SRP154291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
JUND	ENCODE Transcription Factor Targets	1.0	null
K562_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164097
GTEX-XUZC-0008-SM-4BOQG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05692
apomorphine-1923	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LRPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38537
GFI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24138
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-211	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
phrenic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.614571
GSE182680,GSE182683_0_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
K562_M344_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190375
abnormal male reproductive system physiology	MPO Gene-Phenotype Associations	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
Peripheral nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.254
GTF2H1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42045
Arterial blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.008
smooth muscle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.26889
membrane part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
t-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.110331
protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.29623
BRD-K97935314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2718
serotonin secretion involved in inflammatory response	GO Biological Process Annotations 2015	1.0	null
reserve	GeneRIF Biological Term Annotations	1.0	null
K562_RG108_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0259239
GSE182680,GSE182683_0_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6971-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE192689_0_v_2_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-1.68775
FLI1_megakaryocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GJD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34505
epididymal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.276846
K562_AC480_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0513105
GSE233679_14_v_15_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
respiratory epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.259254
K562_TMP195_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0221688
Acid phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.624
&ALPHA;&BETA;-MEATP	DGIdb Drug Targets 2026	1.0	1.203
JOSD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17368
anion transport	GO Biological Process Annotations 2015	1.0	null
coordination	GeneRIF Biological Term Annotations	1.0	null
FBRSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.82069
MED27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70863
IA-LM	GDSC Cell Line Gene Expression Profiles	-1.0	-1.74617
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0281562
PMC10810548-pone.0289518.s002.xlsx-SOM_w_identifiers-target_gene_GRHL3	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_14180_KD_HOXBAS3_SRP222971	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.46409
response to nitrogen compound	GO Biological Process Annotations 2015	1.0	null
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
synaptic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.430647
GTEX-S95S-1326-SM-2XCDK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904983
adult stem cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.129187
K562_Pelitinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0213419
Cystitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.008
Prostate adenocarcinoma_PRAD_TCGA-HI-7169-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CASP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13087
BRD-K44212150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50234
enteric nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.215928
membrane lipid metabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN015_HEPG2_48H:G20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09917
pericarp	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.154539
Encephalopathy	DisGeNET Gene-Disease Associations	1.0	null
NR2F2	ENCODE Transcription Factor Targets	1.0	null
GTEX-P78B-0726-SM-2S1O2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37285
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.01018
GSE111247_2_v_1_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Glutamatergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.228
K562_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0416004
K562_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195894
nrf1_22586274_liver_lof_mouse_gpl4134_gse35124	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.050341
CTCF-26484167-CHIP-SEQ-BCELLS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML2-OVERLAP_GENES_RUNX3	Rummagene Transcription Factor Associations 2026	1.0	null
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
transmembrane signaling receptor activity	GO Molecular Function Annotations 2015	1.0	null
cell periphery	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
TCAP	Pathway Commons Protein-Protein Interactions	1.0	null
smooth muscle	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
K562_SNS-314 Mesylate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162635
Bradyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.681
hsa-let-7d	TargetScan Predicted Conserved microRNA Targets	1.0	0.123298
Perturb_13024_KO_NFKB2_SRP268648	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.61411
Pheochromocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.247
adenine	GeneRIF Biological Term Annotations	1.0	null
Subthalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.63
Limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
Urinary system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.74755
BRD-K38493972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24879
BRD-K98437821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.15082
ribonucleoside binding	GO Molecular Function Annotations 2015	1.0	null
K562_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195074
PMC6904118-NIHMS1544763-supplement-5.xlsx-MYB_Individual-MYB_sgRNA-9_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-A479-01A-31R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EID2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.39032
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12469
GTEX-V955-2626-SM-3NM9F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29367
TMEM250	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53315
FRS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5715
Lung adenocarcinoma_LUAD_TCGA-MP-A4T4-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Neuroblastoma	DisGeNET Gene-Disease Associations	1.0	null
Age related macular degeneration	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
BRD-K13076765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1182
GSE228263_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
smooth muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.67406
BRD-K10580455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.33206
BRD-K09878843	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0958
hsa-miR-185	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
BRD-K91820608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23639
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7761
diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.061121
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_69_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K93248080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.1735
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.38
magnocellular superficial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13046
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5712-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-2355-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
BRD-K95574976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13114
divalent metal ion transport	GO Biological Process Annotations 2015	1.0	null
containing	GeneRIF Biological Term Annotations	1.0	null
excitatory extracellular ligand-gated monoatomic ion channel activity	GO Molecular Function Annotations 2025	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-2K-A9WE-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Allergic contact dermatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
heart	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.73803
Blood-platelet	Tabula Sapiens Gene-Cell Associations	1.0	-0.0235936
GSE89018_12_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FUS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.56861
SUDHL10	DepMap CRISPR Gene Dependency	1.0	2.03151
divalent inorganic cation transport	GO Biological Process Annotations 2015	1.0	null
superficial stratum of r8BL	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.58005
K562_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163682
PMC8020666-pnas.2015855118.sd09.xlsx-LPS_4_human_DRSG_higherRes-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_1689_KO_Rptor_SRP101878	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.41274
cell projection membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.109713
CRCGN014_HEPG2_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09033
PCNX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5468
HSD11B1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00463
neuromuscular junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.317082
MAZ_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR3C1-34362910-WISTARRAT-HIPPOCAMPUS	ChEA Transcription Factor Targets 2022	1.0	null
dimethyloxalylglycine-584	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RASAL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00428811
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_60_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC6664293__F4	PFOCR Pathway Figure Associations 2023	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pain agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.68
ZMIZ1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Ofloxacin_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0299255
Blood coagulation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
circulatory system process	GO Biological Process Annotations 2015	1.0	null
Synaptic membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.41
BRD-K33037101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26614
ONECUT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07625
epididymis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.235167
PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S18-Table_S18_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-002_4H_vs_DMSO_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
Serotonin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.996
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
regulation of system process	GO Biological Process Annotations 2015	1.0	null
cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.378122
Hiv Infections	DisGeNET Gene-Disease Associations	1.0	null
Axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.036
GTEX-QESD-0008-SM-447B2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68264
GTEX-R3RS-0008-SM-48FF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
stress	GeneRIF Biological Term Annotations	1.0	null
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.95
BRD-K94088431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.50287
CACO-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.870342
graft-versus-host disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.256
GSE133516_0_v_3_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC43A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57223
multicellular organismal reproductive process	GO Biological Process Annotations 2015	1.0	null
ZBTB17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34667
reduction	GeneRIF Biological Term Annotations	1.0	null
NR3C2-34362910-WISTARRAT-HIPPOCAMPUS-STRESS	ChEA Transcription Factor Targets 2022	1.0	null
GSE174735_1_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYL9	Pathway Commons Protein-Protein Interactions	1.0	null
cell activation	GO Biological Process Annotations 2015	1.0	null
vas deferens	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.77832
lung	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.065838
K562_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0221933
hsa-miR-4650-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
transport	GO Biological Process Annotations 2015	1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-O5YV-0008-SM-4E3HP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43206
pain disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.362239
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
pkc	Phosphosite Textmining Biological Term Annotations	1.0	null
CRCGN009_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.36703
Major depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.4
NSUN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43258
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0222456
macromolecular complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.276304
K562_WP1066_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0238865
lateral orbital frontal cortex (area 12/47)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.20238
dinoprostone-6547	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cytoplasmic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.420036
Lung adenocarcinoma_LUAD_TCGA-55-8621-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLCN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20837
MGAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80514
K562_Decitabine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164246
umbilical artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.32753
CRO-AP2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
regulation of apoptotic process	GO Biological Process Annotations 2015	1.0	null
Elevation of cytosolic Ca2+ levels	Reactome Pathways 2024	1.0	null
MNX1-26342078-MIN6-4N-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE167956_4_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
kidney	HPA Tissue Protein Expression Profiles	-1.0	-1.03292
NF023	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
periventricular stratum of r3Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.3113
BRD-K37454185	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48148
K562_S-Ruxolitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0404135
GPATCH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23139
Gingival epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.597
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.339
Fields of Forel	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67587
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE123943_4_v_5_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BOD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83226
SOX2_Deficiency_GDS4853_320_human_AZ-521 gastric cancer (GC) cell line - 12 Hours	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Paragigantocellular reticular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.73378
gfi1b_22201127_amulv_gof_mouse_gpl6246_gds4302	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.130713
nuclear part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
ZEB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05939
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
ovary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.055279
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36443
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34577
Vomeronasal organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.678
GTEX-XUZC-1226-SM-4BRVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06415
TM7SF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88507
CFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56772
reproductive system phenotype	MPO Gene-Phenotype Associations	1.0	null
Sarcoma_SARC_TCGA-K1-A3PO-11A-12R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_AMG-900_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136838
Hyperalgesia	DisGeNET Gene-Phenotype Associations	1.0	null
GTEX-P4PP-1826-SM-2S1NT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08095
GSE199606_6_v_4_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11067031-pnas.2317690121.sd06.xlsx-gene_list_14_txt-Differentially_expressed_genes_between_PML_RARA_GFP_vs_C88A_PML_RARA_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
FLI1_megakaryocyte_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Integrin alphaM-beta2 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.783
BRD-K04631545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.24839
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ventrolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1572
OVCAR8	CCLE Cell Line Gene CNV Profiles	1.0	1.87526
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.3918
GSE89018_6_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
interpositus (intermediate) nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.02724
DNAJC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73808
BRD-K88936403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4903
K562_Avagacestat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0794313
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.81133
RNF112	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23301
GSE218060_5_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
16024625-SuppTable2a	GeneSigDB Published Gene Signatures	1.0	null
BRD-K67597437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47244
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.16662
regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO Biological Process Annotations 2015	1.0	null
CRCGN008_HEPG2_24H:I02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00735
H3K27me3_erythroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
renal tubule epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.359664
dh82	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.538
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7593-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BLACAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71428
Taste bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.329
GSE89018_6_v_8_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K76611906	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3291
Perturb_1112_KO_Vcan_SRP167386	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.42595
GTEX-X638-0008-SM-47JZ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67631
GSE89018_10_v_2_cry2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GATA1-19941827-MEL-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.305361
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829117
CHD4	ENCODE Transcription Factor Targets	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.29
K562_Enzastaurin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0311247
Status epilepticus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.493
frontal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.098538
CLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15946
Toxoplasmosis, Cerebral	DisGeNET Gene-Disease Associations	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8301-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
purinergic nucleotide receptor activity	GO Molecular Function Annotations 2015	1.0	null
KLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32364
BRD-K10412976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54672
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
COLO 853	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26645
GATA3-22897851-JUKARTE6-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE107505_3_v_2_nanog_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_GM12864_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral intermediate part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.44437
Rectum adenocarcinoma_READ_TCGA-AF-2691-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GATA3-21878914-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K62892366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34901
parastrial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20422
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.922791
kinase	GeneRIF Biological Term Annotations	1.0	null
carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051429
Seminal vesicle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
BRD-K87875370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74598
Spinal root	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.638
Heavy chain immunoglobulin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.035
heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.457109
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18286
GSE133691_1_v_3_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intrinsic component of nuclear inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
ETV2::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1437
LY2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.920901
Demyelinating disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.859
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.14413
RL95-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SNU283	CCLE Cell Line Gene CNV Profiles	1.0	2.50907
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
mononuclear cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.108022
PHF8	ENCODE Transcription Factor Targets	1.0	null
GSE168807_0_v_7_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NFIX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7948
PMC9288051-13046_2022_2428_MOESM4_ESM.xlsx-Super_enhancers_in_AML3-CLOSEST_GENE_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Enteric plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.207
hsp90	GeneRIF Biological Term Annotations	1.0	null
thereby	GeneRIF Biological Term Annotations	1.0	null
Regenerative Anemia	DisGeNET Gene-Disease Associations	1.0	null
initiated	GeneRIF Biological Term Annotations	1.0	null
muscles	GeneRIF Biological Term Annotations	1.0	null
intracellular part	GO Cellular Component Annotations 2015	1.0	null
Systemic sclerosis (anti-topoisomerase-positive)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.6
BRD-K01980291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.8251
GTEX-WWYW-0011-R11A-SM-3NB38	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.889123
MAGED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22136
PSMB8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7255
Cheek pouch	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.585
16458935-Table3	GeneSigDB Published Gene Signatures	1.0	null
BRD-K82805160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51045
GTEX-T5JC-0226-SM-32PMA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94828
VTA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57363
outer CP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.857354
RVH-421	GDSC Cell Line Gene Expression Profiles	-1.0	-1.54736
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE232836_2_v_6_morphine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MYPOP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.69663
hsa-miR-204	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BOP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502577
BRD-K81623965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37815
CISD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04539
GTEX-V1D1-2626-SM-4JBJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68589
GTEX-S341-0008-SM-4AD6D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24585
platelet	GeneRIF Biological Term Annotations	1.0	null
Perturb_716_KO_USP18_SRP303135	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
ZBTB7A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rho	GeneRIF Biological Term Annotations	1.0	null
PMC8766486-42003_2021_2990_MOESM3_ESM.xlsx-ST12-Unnamed_8_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Aggressive Non-Hodgkin Lymphoma	DisGeNET Gene-Disease Associations	1.0	null
RHOXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90131
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849934
K562_Azacitidine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0198614
Narcolepsy	DisGeNET Gene-Disease Associations	1.0	null
Brain cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.441
tnfalpha	GeneRIF Biological Term Annotations	1.0	null
BRD-K76672835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07145
Arteriosclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.645
GTEX-XBED-0008-SM-47JWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72035
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.02929
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00801
Coccidiosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.183
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01572
BRD-K52037352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58818
CPLX1	Pathway Commons Protein-Protein Interactions	1.0	null
NCIH1105	CCLE Cell Line Gene Expression Profiles	-1.0	-1.46603
abnormal germ cell morphology	MPO Gene-Phenotype Associations	1.0	null
vestibulocochlear nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.641643
TXNDC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97352
crotamiton-4628	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SJXC-0426-SM-2XCFH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.92529
RLF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.73902
CALB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00553097
BRD-K31577322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34503
vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.376202
BRD-K27888332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1666
GSE181966_5_v_3_has2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WZTO-1126-SM-3NM93	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02723
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.879
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.455
bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.053168
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98206
Axon terminus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.93
Sympathetic chain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.701
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.90705
VAESBJ	DepMap CRISPR Gene Dependency	1.0	3.39573
BRD-K83877780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31856
Ulcerative colitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.208
GSE159148_0_v_1_sdc1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CASP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86666
MRS 2219	DGIdb Drug Targets 2026	1.0	2.406
Choanomastigote	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
ZNF175	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.2175
PMC9288051-13046_2022_2428_MOESM6_ESM.xlsx-Super_enhancers_in_B-ALL3-CLOSEST_GENE_PAX5	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.153
CEP152	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09932
CACNB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86941
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-LP-A4AW-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WDR46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42635
K562_Navitoclax_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.020632
K562_Prednisone_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0270288
CS1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lacrimal gland acinar cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.635
P31FUJ	CCLE Cell Line Gene Expression Profiles	1.0	1.45375
embryonic structure	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-NPJ7-0008-SM-4E3JS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998038
BRD-K12097074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56079
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.786
ARHGEF25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19592
K562_Motesanib Diphosphate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219424
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.57
Exocytic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.599
Paraventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.143
integral component of postsynaptic membrane	SynGO Synaptic Gene Annotations	1.0	null
RPL35A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55306
ofloxacin-4696	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TCEAL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00343
HS821T	CCLE Cell Line Gene CNV Profiles	1.0	1.42704
Phrenic nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.966
abnormal male reproductive system morphology	MPO Gene-Phenotype Associations	1.0	null
agonists	GeneRIF Biological Term Annotations	1.0	null
RUNX1-22412390-EML-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_45_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-WHSE-1126-SM-3NMBU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74086
STAT3	ENCODE Transcription Factor Targets	1.0	null
CGRP receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.822
MJ	DepMap CRISPR Gene Dependency	1.0	7.65946
MHHCALL4	CCLE Cell Line Gene Expression Profiles	1.0	1.60538
Axon collateral	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.743
GSE203584_1_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Paraventricular hypothalamic nucleus, parvicellular division, anterior parvicellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.15625
BRD-K93335719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01765
GSE125862_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
doxorubicin-4610	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
19755993-Table3	GeneSigDB Published Gene Signatures	1.0	null
CABLES2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56035
ACTR3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57518
secretory granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.172735
GTEX-PLZ4-1326-SM-2S1O7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39826
FOXO1_01_322	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.79525
FBXO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20345
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1256
Perturb_7052_KO_Grk2/Grk5/Grk6_SRP090395	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.76603
BRD-K98682310	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43467
FOXJ2::ELF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.964
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle zone of StrSe	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32512
astrocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.338914
GTEX-VJYA-0826-SM-4KL1M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948704
vein disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.397098
TNP-ATP	DGIdb Drug Targets 2026	1.0	2.406
A549	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.72476
K562_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0449866
K562_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0230623
Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A83W-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZMYND8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05058
Autoimmune disease of gastrointestinal tract	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.185
hsa-miR-4458	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
Dura mater	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.913
KRAS.AMP.LUNG_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYBPC3	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K77320034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34072
STK16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46622
K562_AC480_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.103109
BRD-K56699877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74466
C2orf15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92296
Somatoform disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.757
BRD-K28195874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26457
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
regulation of anatomical structure size	GO Biological Process Annotations 2015	1.0	null
ZDHHC8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1127
axon part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.447656
JURKAT	CCLE Cell Line Gene Expression Profiles	-1.0	-1.85321
Perturb_4013_OE_AHR_SRP262152	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.97662
GTEX-XPVG-0826-SM-4B654	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857891
amygdala	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.165439
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.17724
BRD-K87995704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25905
activation of cysteine-type endopeptidase activity involved in apoptotic process	GO Biological Process Annotations 2015	1.0	null
K562_AT9283_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0202392
Neuromuscular junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.372
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	1.0	1.20901
BZATP	DGIdb Drug Targets 2026	1.0	0.9624
RBM18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60138
Megakaryocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.854
B4GALT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8542
BORCS7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57143
BFTC-905	GDSC Cell Line Gene Expression Profiles	-1.0	-2.00166
regions	GeneRIF Biological Term Annotations	1.0	null
positive regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
Primary motor area, Layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14239
hmc1	HPA Cell Line Gene Expression Profiles	1.0	0.846257
TUHR10TKB	CCLE Cell Line Gene Expression Profiles	-1.0	-1.78835
CTCF	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
CTSK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03232
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SLC25A37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69879
BRD-K44167510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0656
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4EP-0826-SM-3P5YK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71068
UBE2G1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04511
oxidative	GeneRIF Biological Term Annotations	1.0	null
GTEX-UPIC-0326-SM-4IHJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0692
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68412
TAL1-20887958-HPC-7-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
KRAS.LUNG.BREAST_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
BRD-K98601267	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04851
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950485
hematopoietic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.561644
limiting	GeneRIF Biological Term Annotations	1.0	null
SORBS3	Pathway Commons Protein-Protein Interactions	1.0	null
nucleotides	GeneRIF Biological Term Annotations	1.0	null
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	1.0	2.00335
cranial nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.707631
gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.278312
Exodeoxyribonuclease VII complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.922
GTEX-WH7G-0008-SM-4LVNM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67856
K562_Resveratrol_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.056548
GTEX-Q2AG-0008-SM-48U2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43985
BRD-K08799663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30776
CRCGN015_MCF10A.TP53.M_24H:J08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18185
Gustatory areas, layer 4	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.15762
BRD-K56065989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97053
PMC4519778-srep12524-s2.xls-Table_S5-Supplementary_Table_S5_List_of_all_identifed_alternative_transcription_events_betweeb_MDMs_and_IPSDMs_and_in_LPS_response_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FOXP1-21924763-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.399
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26767
A204	BioGPS Cell Line Gene Expression Profiles	1.0	1.271
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.0537
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HEK-293 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.763
nicergoline-2220	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HDAC_INHIBITION - trichostatin A_GDS2452_709_human_Endothelial cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.10883
GSE164874_5_v_11_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CAMK2N1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4047
typ3	GeneRIF Biological Term Annotations	1.0	null
negatively	GeneRIF Biological Term Annotations	1.0	null
GSE109530,GSE109531_2_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K87580376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07305
positive regulation of apoptotic process	GO Biological Process Annotations 2015	1.0	null
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842033
MYL1	Pathway Commons Protein-Protein Interactions	1.0	null
BZRAP1	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
Benign Prostatic Hyperplasia	DisGeNET Gene-Disease Associations	1.0	null
pronephros	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.61699
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.94
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47992
CCK-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
t30-blood-rna_consensus	MoTrPAC Rat Endurance Exercise Training	1.0	9.66381
GSE233679_6_v_4_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_3245_OE_RUNX3_SRP330291	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.49639
INO80B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.74285
BRD-K34252131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47295
BRD-K68580555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42781
NF449	Guide to Pharmacology Chemical Ligands of Receptors	1.0	null
GSE110178_5_v_3_tranylcypromine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850378
biological_process	GO Biological Process Annotations 2015	1.0	null
contribution	GeneRIF Biological Term Annotations	1.0	null
BRD-K36563688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.45293
H3K4me1_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.892185
HCC-1954 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.52
GTEX-PVOW-0726-SM-2XCF5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84391
SLC35E4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77809
monoatomic cation channel activity	GO Molecular Function Annotations 2023	1.0	null
H3K4me1_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.04047
congestive heart failure	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.226262
GSE182680,GSE182683_7_v_8_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE126463_5_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
integral component of nuclear inner membrane	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
BRD-K58836556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07183
synaptic transmission	GO Biological Process Annotations 2015	1.0	null
glioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23176
voltage-gated sodium channel complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.797
myc_20940306_e13dot5_erythroblast_purified_from_liver_gof_mouse_gpl6885_gse18558	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.094672
BRD-K24170552	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36257
estropipate-6068	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
muscular dystrophy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.190168
BRD-K51298794	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42989
ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4492
PMC9181267-mmc4.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
integral component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.729732
GTEX-UJHI-1926-SM-3DB8Z	GTEx Tissue Sample Gene Expression Profiles	1.0	2.38449
GATA1_G1E-ER4_mm9_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.932813
GTEX-R53T-0008-SM-48FEW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69996
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XGQ4-2426-SM-4AT55	GTEx Tissue Sample Gene Expression Profiles	1.0	2.25799
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10515843-media-1.xlsx-Table_7_Diff_loop_genes_E_v_S-Supplementary_Table_7_Genes_that_involve_significant_differential_looping_in_pediatric_primary_B_cell_CTCF_peaks_compared_to_GM12878_CTCF_peaks_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
DNAL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17391
PUM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73456
GTEX-NL4W-0011-R4a-SM-2I5GZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12083
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mitoxantrone-6755	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
gave	GeneRIF Biological Term Annotations	1.0	null
mutant	GeneRIF Biological Term Annotations	1.0	null
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Low compliance bladder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.451
KARPAS620	CCLE Cell Line Gene Expression Profiles	1.0	1.41119
XPO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81688
essential	GeneRIF Biological Term Annotations	1.0	null
TNNT1	Pathway Commons Protein-Protein Interactions	1.0	null
exocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.070663
BRD-K40985311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42712
monoatomic cation transmembrane transporter activity	GO Molecular Function Annotations 2023	1.0	null
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.31088
K562_Lomustine_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0356871
BRD-K56943789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10708
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Entacapone_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0347924
NEB	Pathway Commons Protein-Protein Interactions	1.0	null
VASP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92707
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.58678
CORL24	CCLE Cell Line Gene Expression Profiles	-1.0	-2.44313
GTEX-NL4W-0011-R11A-SM-2I3DW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878324
K562_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176185
K562_Droxinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0310694
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.912176
GTEX-POMQ-2126-SM-2S1OJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50493
BRD-K53046137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26637
HOXD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95467
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894406
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.885
K562_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0230577
AP5S1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56059
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CU-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931233
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.828308
ZNF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.54858
Lung adenocarcinoma_LUAD_TCGA-50-5936-11A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.15296
IDO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00507589
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MECOM	ChEA Transcription Factor Targets	1.0	null
PMC8390472-41598_2021_96750_MOESM1_ESM.xlsx-ST12-Unnamed_12_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD1C-CD141- dendritic cell_Blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
K562_AG-14361_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0280625
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TFAP2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carotid artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.036
Secretory granule membrane	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
BRD-K03361106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.086
roxarsone-2950	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836954
effects	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-5481-11A-01R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.409731
FBXO45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51507
NCIH1648	CCLE Cell Line Gene Expression Profiles	-1.0	-1.53096
Perturb_8992_KD_PAX9_SRP407074	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Lung adenocarcinoma_LUAD_TCGA-55-6642-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRCA1	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6324-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NLRP3 inflammasome complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.915
K562_Lomustine_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0320165
GTL-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27987
responses	GeneRIF Biological Term Annotations	1.0	null
K562_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185619
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28665
specific granule	GO Cellular Component Annotations 2023	1.0	null
K562_Glesatinib(MGCD265)_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176627
NKX2-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27229
JTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.84568
BRD-K00537235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32066
GSE239784_1_v_0_sat1_human	RummaGEO Gene Perturbation Signatures	1.0	null
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.838836
PLA2G4A	Pathway Commons Protein-Protein Interactions	1.0	null
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.428783
granule cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.320227
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pancreatitis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.119
PMC12339377-41587_2024_2403_MOESM3_ESM.xlsx-TableS6_LPS_screen_GEPs-Unnamed_34_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5443-01A-01R-1514-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30563122	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34601
Muscular system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.07944
K562_XAV-939_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020342
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052079
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Heart Failure	DisGeNET Gene-Disease Associations	1.0	null
TNNC1	Pathway Commons Protein-Protein Interactions	1.0	null
ZSCAN18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1641
15474998-tableS1c	GeneSigDB Published Gene Signatures	1.0	null
considered	GeneRIF Biological Term Annotations	1.0	null
HIPK1_knockout_170_GSE39253	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.37966
BRD-K34297711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34466
GTEX-NPJ7-2726-SM-2I3FT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12282
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.188632
20215539-SuppTable2a	GeneSigDB Published Gene Signatures	1.0	null
methyldopa-1619	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
astroglial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.390799
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.860533
Lung adenocarcinoma_LUAD_TCGA-50-5930-11A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
pancreatic ductal carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.144116
mantle zone of r9BM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75105
KCNK15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00196
BRD-K86817746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.99035
CRCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81753
HEL	GDSC Cell Line Gene Expression Profiles	1.0	1.51634
CDC42EP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30567
layer 2 of PCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20173
DPP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5964
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K49992772	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47111
Smooth muscle	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SMC1-22415368-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ca2entry	GeneRIF Biological Term Annotations	1.0	null
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_IOX2_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0173352
membrane	GO Cellular Component Annotations 2015	1.0	null
integral component of presynaptic active zone membrane	SynGO Synaptic Gene Annotations	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sympathetic nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.641
HMGN3	ENCODE Transcription Factor Targets	1.0	null
ATP6V0C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24896
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
Calcium	HMDB Metabolites of Enzymes	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5169-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Satellite glial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.683
Immune System	Reactome Pathways 2024	1.0	null
TAL1	ChEA Transcription Factor Targets	1.0	null
leaf	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.06536
male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.361133
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5369-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AI-1726-SM-2S1PZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17365