association dataset threshold value standardized value CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null ribavirin_homo sapiens_gpl570_gds4391 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Poisoning CTD Gene-Disease Associations 1.0 1.62938 GTEX-P4QR-1026-SM-2I5GP GTEx Tissue Sample Gene Expression Profiles 1.0 0.85445 Perturb_14180_KD_HOXBAS3_SRP222971 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -13.7736 CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE171837_0_v_3_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WRHU-0926-SM-4E3IG GTEx Tissue Sample Gene Expression Profiles 1.0 2.04141 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Fatty Liver CTD Gene-Disease Associations 1.0 1.4332 MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XV7Q-0926-SM-4BRVQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.26772 LCLC-97TM1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.34278 hsa-miR-4512 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 RPS18 Pathway Commons Protein-Protein Interactions 1.0 null SNUC1 CCLE Cell Line Gene CNV Profiles 1.0 1.5061 hsa-miR-4430 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Perturb_8123_KD_U2AF2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.24696 KA-29-AB08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.49049 t-UTP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.709 MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12869_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null body of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.863732 H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-A513-01A-12R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Eukaryotic translation initiation factor 4F complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.862 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-175-VII Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.893081 GTEX-WK11-0926-SM-3NMAU GTEx Tissue Sample Gene Expression Profiles 1.0 1.2556 HDAC2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DA-58-LZ09_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.235327 Heart Defects, Congenital CTD Gene-Disease Associations 1.0 1.3385 CTCF_keratinocyte_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55E-2726-SM-48FCX GTEx Tissue Sample Gene Expression Profiles 1.0 1.09854 GSE122101,GSE122103_3_v_1_ssu72_mouse RummaGEO Gene Perturbation Signatures 1.0 null SW48 CCLE Cell Line Gene Expression Profiles 1.0 1.97164 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2739 RERFGC1B CCLE Cell Line Gene CNV Profiles 1.0 2.01601 RPL18A Pathway Commons Protein-Protein Interactions 1.0 null MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RT-112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.942041 RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2895-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE201309_5_v_3_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null Elagolix sodium_NCI-H23 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0169497 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.28246 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE116492,GSE116495_3_v_2_stag2_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM10847_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NANOG_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T8EM-1326-SM-3DB7G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2958 FOSL2 ENCODE Transcription Factor Targets 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null GABPA_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WSU-NHL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_6679_KO_SCAP_SRP255872 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.31951 posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.41385 JE-22-JR20_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.489281 GTEX-T5JC-2126-SM-32PMO GTEx Tissue Sample Gene Expression Profiles 1.0 1.04268 PLC/PRF/5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.918169 Taenia tecta, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1446 CTCF_GM10248_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -2.06114 BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.61139 abnormal oogenesis MPO Gene-Phenotype Associations 1.0 null MARK1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30026 JHH-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null YY1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.332 PMC10542516-media-7.xlsx-EPC_siCTL_vs_EPC_SMAD1-5_Sample-gene_id_SMAD1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-R3RS-0626-SM-48FE1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.31112 OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.931366 POU2F2 ENCODE Transcription Factor Targets 1.0 null PMC10350819-EMBJ-42-e113168-s007.pdf-108-ENSG00000164048_ZNF589 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_7365_KD_EglN2_SRP325972 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 14.5789 Kidney Chromophobe_KICH_TCGA-KN-8432-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Neonatal myasthenia gravis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.055 GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10374 FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC13137955-ijbsv22p4243s2.xlsx-Sheet1-hTFtarget_E2F3_E2F3 Rummagene Transcription Factor Associations 2026 1.0 null HC-63-SV27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222913 ZR7530 CCLE Cell Line Gene Expression Profiles -1.0 -2.48936 GTEX-PWOO-2326-SM-2S1PQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04293 GTEX-NL4W-0011-R11A-SM-2I3DW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02598 Brain - Cortex GTEx Tissue Gene Expression Profiles 2023 1.0 3.60931 H3K4me3_Rectal Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleus accumbens, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.47532 organelle GO Cellular Component Annotations 2015 1.0 null Alkyl hydroperoxide reductase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.766 primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.954993 H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZNF528 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.5844 Eye disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.408 GTEX-UPK5-2026-SM-4JBIM GTEx Tissue Sample Gene Expression Profiles 1.0 1.46829 EF-80-OD07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206592 GTEX-QV44-0926-SM-2S1RH GTEx Tissue Sample Gene Expression Profiles 1.0 0.846557 NCIH1573 CCLE Cell Line Gene Expression Profiles 1.0 1.82838 GSE242049_1_v_0_txndc5_mouse RummaGEO Gene Perturbation Signatures -1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.51762 Feeling fed-up GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.8 Periventricular region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05342 GSE142684_3_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CAS1 DepMap CRISPR Gene Dependency 1.0 2.61456 Perturb_9985_KD_U2AF1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.3264 PMC10117100-msphere.00056-23-s0008.xlsx-2B-Supplementary_Table_S2B_mRNAseq_analysis_genes_significantely_downregulated_upon_E2F4-5_knockdown_in_38HK_E2F4 Rummagene Transcription Factor Associations 2026 1.0 null KDM1A ENCODE Transcription Factor Targets 1.0 null GTEX-RN64-1826-SM-48FDV GTEx Tissue Sample Gene Expression Profiles 1.0 1.78029 GSE227698_2_v_0_g0s2_human RummaGEO Gene Perturbation Signatures 1.0 null CHD1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null Perivitelline space COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.166 SUZ12 ENCODE Transcription Factor Targets 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q3-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE190384,GSE190386_3_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7072-01A-21R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE123638,GSE123639_3_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null WM88 DepMap CRISPR Gene Dependency 1.0 2.64916 Brain Lower Grade Glioma_LGG_TCGA-CS-6186-01A-12R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SE5C-0326-SM-4BRWX GTEx Tissue Sample Gene Expression Profiles 1.0 0.876949 Cornelia de Lange syndrome 3 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.243 RAD21_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal female germ cell morphology MPO Gene-Phenotype Associations 1.0 null H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.03022 BD-96-HO33_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.27693 Gluteal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.522 ANKFY1 Pathway Commons Protein-Protein Interactions 1.0 null GSE131649_6_v_0_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OIZG-0226-SM-2TC5L GTEx Tissue Sample Gene Expression Profiles 1.0 1.03261 GSE224096_2_v_0_cocaine_human RummaGEO Drug Perturbation Signatures -1.0 null VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19057 GTEX-UPK5-1626-SM-4JBHI GTEx Tissue Sample Gene Expression Profiles 1.0 0.859357 CTCF_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null SIN3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64809 GSE215086_1_v_7_batf_human RummaGEO Gene Perturbation Signatures 1.0 null rna metabolic process GO Biological Process Annotations 2015 1.0 null DB-29-HQ45_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201347 abnormal reproductive system physiology MPO Gene-Phenotype Associations 1.0 null BD-62-ZF67_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.321151 GSE206093,GSE206094_1_v_3_isl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null AB-37-JM16_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.273243 GTEX-POYW-0826-SM-2XCEM GTEx Tissue Sample Gene Expression Profiles 1.0 1.39125 GSE114992,GSE114993_4_v_2_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OCUB-M COSMIC Cell Line Gene Mutation Profiles 1.0 null RB-55-KL42_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.310664 H4K20me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Hoxa11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.3019 GTEX-UJHI-0426-SM-3DB8Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1747 CTCF_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180200,GSE180201_12_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE211286_7_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null layer 2 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.38553 ERG_01_316 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.64547 CTCF_GM12875_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNOS-1526-SM-32PLW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59926 GTEX-SJXC-0526-SM-2XCFG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28795 CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCLAF1 ENCODE Transcription Factor Targets 1.0 null Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.459 PMC11143964-jciinsight-9-161356-s009.pdf-1-ZHX1_ZHX1 Rummagene Transcription Factor Associations 2026 1.0 null shell of P-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.55223 MRPS22 Pathway Commons Protein-Protein Interactions 1.0 null polya GeneRIF Biological Term Annotations 1.0 null intermediate stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01 K562_Fasudil_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157721 GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25969 GSE209911_0_v_1_ncstn_human RummaGEO Gene Perturbation Signatures -1.0 null amygdaloid complex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.8452 MDAMB436 CCLE Cell Line Gene CNV Profiles -1.0 -1.57398 POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1-21867929-CD8-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HMGN3 ENCODE Transcription Factor Targets 1.0 null ZBTB7A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H716 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.991307 r7 part of the nucleus of Roller Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09512 GD-46-BU97_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.481911 Perturb_15565_KD_YAP1_SRP333272 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.78076 Brain Lower Grade Glioma_LGG_TCGA-HT-A5RC-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null orbital frontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13613 GTEX-NPJ7-0011-R11A-SM-2I3E8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05415 GSE186647,GSE217287_1_v_3_hnrnpc_human RummaGEO Gene Perturbation Signatures 1.0 null E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CE-37-XI06_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.228378 appendices_4c HPA Tissue Sample Gene Expression Profiles 1.0 0.86173 GSE131649_6_v_10_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.1883 AOB, internal plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05972 Transcription factor TFIIA complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.587 AF-48-FX20_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.353655 GSE195568_1_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null female infertility MPO Gene-Phenotype Associations 1.0 null GTEX-WH7G-1626-SM-4LVMY GTEx Tissue Sample Gene Expression Profiles 1.0 0.844468 r8 part of inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02997 EZH2 ENCODE Transcription Factor Targets 1.0 null cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.138341 icSARA deltaORF6_0Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.20741 SR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.97219 GSE190384,GSE190386_0_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null Thyroid gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.431 BE-50-RK99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.264142 UBTF ENCODE Transcription Factor Targets 1.0 null GTEX-Q2AI-1126-SM-48U19 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17545 Spindle Cell Oncocytoma Of The Adenohypophysis DisGeNET Gene-Disease Associations 1.0 null GSE139455_7_v_3_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null PRRG3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24032 MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null extracellular vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.057922 COR-L105 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-QMR6-0011-R11A-SM-32PKK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18361 GSE211262,GSE211263_3_v_1_pbrm1_human RummaGEO Gene Perturbation Signatures 1.0 null SCC90 COSMIC Cell Line Gene Mutation Profiles 1.0 null ERRalpha_Deficiency_GDS2727_646_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null vitamin c_homo sapiens_gpl570_gse11919 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null icSARS CoV_54Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.7524 SK-GT-2 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.20294 BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UACC62 DepMap CRISPR Gene Dependency 1.0 3.07098 POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RPL23 Pathway Commons Protein-Protein Interactions 1.0 null FOXM1 ENCODE Transcription Factor Targets 1.0 null AC-28-RT00_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.536511 KDM1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35814 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08559 GTEX-PLZ6-1526-SM-2S1OC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28957 HEL9217 CCLE Cell Line Gene CNV Profiles -1.0 -1.47353 CTCF_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOTO-0526-SM-4B662 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75522 GSE182680,GSE182683_5_v_4_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Acute endophthalmitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.102 Liver Diseases CTD Gene-Disease Associations 1.0 1.09047 thyroid GTEx Tissue Gene Expression Profiles 1.0 1.31453 layer 1 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.11913 GTEX-U3ZH-0226-SM-3DB7B GTEx Tissue Sample Gene Expression Profiles 1.0 1.03911 Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.14 GTEX-Q734-0326-SM-48U15 GTEx Tissue Sample Gene Expression Profiles 1.0 0.875489 HSPB8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20807 Anterior midgut TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.704 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.70064 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE168797_2_v_0_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null abnormality of cardiovascular system physiology GWASdb SNP-Phenotype Associations 1.0 0.437102 MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.984036 GSE114992,GSE114993_0_v_5_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null Colon adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.132 GTEX-N7MS-0011-R11A-SM-2HMJS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01624 ACTL6A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -4.08958 BCL3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS9 Pathway Commons Protein-Protein Interactions 1.0 null RVH421 DepMap CRISPR Gene Dependency 1.0 2.62664 Perturb_2544_KO_OVOL2_SRP347819 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE146840,GSE146842_3_v_2_qrich1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_GM12866_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1734 COSMIC Cell Line Gene Mutation Profiles 1.0 null several GeneRIF Biological Term Annotations 1.0 null GSE226544_1_v_0_hnrnpa2b1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NUP205 Pathway Commons Protein-Protein Interactions 1.0 null HNF4alpha_KO_GDS1916_168_mouse_Embryonic liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null RMDN3 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null decreased cumulus expansion MPO Gene-Phenotype Associations 1.0 null CD-35-BD44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.40921 coronary artery disease GWASdb SNP-Disease Associations 1.0 0.757675 BACH1 ENCODE Transcription Factor Targets 1.0 null SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EOMES JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.5867 MBD4 ENCODE Transcription Factor Targets 1.0 null RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14084_KD_FGF13_SRP114701 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE77108_5_v_1_saha_human RummaGEO Drug Perturbation Signatures 1.0 null Skin TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.077 GTEX-OXRN-1326-SM-3LK5V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00807 mRNA cap binding complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.112 NCI-H2170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.888536 Supramolecular complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 Sarcoma_SARC_TCGA-JV-A5VE-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AF-00-QK19_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.590809 ECGI10 CCLE Cell Line Gene Expression Profiles 1.0 1.37859 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NANOG ENCODE Transcription Factor Targets 1.0 null GSE130246_2_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null RNA degradation KEGG Pathways 2026 1.0 null GSE113005_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null UKE-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.88158 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BCL3 ENCODE Transcription Factor Targets 1.0 null GSE125219,GSE125221_5_v_0_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null Chromatoid body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.374 RPS6 Pathway Commons Protein-Protein Interactions 1.0 null ETS1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU216 CCLE Cell Line Gene CNV Profiles 1.0 1.68133 EP300_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WB-82-EL69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.350173 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NL3H-0011-R11A-SM-2I3E6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16935 GTEX-OOBK-2626-SM-2HMKY GTEx Tissue Sample Gene Expression Profiles 1.0 0.881401 skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles -1.0 -2.85836 GTEX-WZTO-0011-R11A-SM-4E3K9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.825192 GTEX-QEL4-0626-SM-3GIJM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42529 GSE60217_1_v_0_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null UOK101 DepMap CRISPR Gene Dependency 1.0 2.21829 VA-92-QP54_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.204097 PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2 Rummagene Transcription Factor Associations 2026 1.0 null putamen, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.956788 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35306 HCC44 CCLE Cell Line Gene CNV Profiles -1.0 -1.34468 FOXA2 ENCODE Transcription Factor Targets 1.0 null TE-15-RO34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.31784 TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Parabrachial nucleus, lateral division, superior lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21088 vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me3_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null lateral (dentate) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10187 SF1 MotifMap Predicted Transcription Factor Targets 1.0 null BXPC3 CCLE Cell Line Gene Expression Profiles -1.0 -1.79868 E2F6_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE249404_0_v_1_oxytocin_human RummaGEO Drug Perturbation Signatures 1.0 null Bundle sheath cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.056 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A439-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16424 GTEX-PWOO-1226-SM-48TCO GTEx Tissue Sample Gene Expression Profiles 1.0 1.18558 ME-31-RM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.560369 ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.945309 Sclerenchyma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.294 GTEX-T6MO-0426-SM-32QOI GTEx Tissue Sample Gene Expression Profiles 1.0 0.999372 G401_SOFT_TISSUE CCLE Cell Line Proteomics 1.0 3.18569 COMMD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36398 HCC2218 COSMIC Cell Line Gene Mutation Profiles 1.0 null CWC15 Pathway Commons Protein-Protein Interactions 1.0 null abnormal female meiosis MGI Mouse Phenotype Associations 2023 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A7TD-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_6670_KO_FGFR4_SRP386785 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.89855 Perturb_12849_KO_Rnf114_SRP301146 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.12418 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01895 Perinucleolar compartment COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.599 KYM-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cerebellar nuclei of CbV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01011 PUR1 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-U412-2026-SM-4DXSI GTEx Tissue Sample Gene Expression Profiles 1.0 1.50502 VMRCRCW_KIDNEY CCLE Cell Line Proteomics 1.0 3.13158 GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58431 XC-88-ZM66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.224203 ESRRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.9058 GSE246567_0_v_1_acat2_human RummaGEO Gene Perturbation Signatures -1.0 null RPL38 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39621 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null JE-72-KV75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.256182 GSE200839,GSE233826_2_v_6_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null SARS-CoV_72Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.4313 CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null chr20_44930268_T_C_b38 GTEx eQTL 2025 1.0 2.04249 Neoplasm Metastasis CTD Gene-Disease Associations 1.0 1.08513 GTEX-S4P3-1626-SM-3K2AZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07332 GSE160817_2_v_9_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null JHH2 CCLE Cell Line Gene Expression Profiles -1.0 -1.62468 GTEX-X8HC-2726-SM-46MUA GTEx Tissue Sample Gene Expression Profiles 1.0 0.910875 H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q734-2026-SM-3GADA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24867 NR2F2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GR-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.888536 Interposed nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63137 nucleic acid binding GO Molecular Function Annotations 2015 1.0 null RFX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF2 ENCODE Transcription Factor Targets 1.0 null YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MO-1426-SM-4DM73 GTEx Tissue Sample Gene Expression Profiles 1.0 0.887139 Perturb_1067_KD_PHF19_SRP188592 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 11.9588 GTEX-P4QR-0726-SM-2I5GO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.972295 SF3A1 Pathway Commons Protein-Protein Interactions 1.0 null LONP1 Pathway Commons Protein-Protein Interactions 1.0 null DA-35-DU85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.700851 H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TCF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.3619 GTEX-R55G-2326-SM-2TC61 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30478 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null BV-173 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.02967 Immature ovarian follicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.484 Lung adenocarcinoma_LUAD_TCGA-97-A4M6-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BB-86-BE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.17416 H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PW2O-0826-SM-48TC5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23041 Ventromedial hypothalamic nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.058 CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WB-48-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.519626 GTEX-R3RS-0726-SM-3GIJR GTEx Tissue Sample Gene Expression Profiles 1.0 1.88115 cell maturation GO Biological Process Annotations 2015 1.0 null CTCF_GM12865_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HE-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE242083,GSE242098_3_v_4_med1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE210682_2_v_3_methadone_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE140322_3_v_2_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_A549_hg19_10 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-GeneID_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null SARS-dORF6_36Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.6431 H2AL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37593 PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-Row_names_CENPX Rummagene Transcription Factor Associations 2026 1.0 null GSE103068_0_v_3_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.489 SW1463 DepMap CRISPR Gene Dependency 1.0 3.41878 NR2F2 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-V1-A8MM-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XV7Q-1526-SM-4BRWB GTEx Tissue Sample Gene Expression Profiles 1.0 1.18982 MORCPR CCLE Cell Line Gene Expression Profiles -1.0 -2.01975 cd8 cells HPM Cell Type and Tissue Protein Expression Profiles -1.0 -1.13487 GA-59-RW04_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.297809 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0737 KA-29-AB08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.219248 primary somatosensory cortex (area S1, areas 3,1,2)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04091 NF-19-JL47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.386228 GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72068 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Superior vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50861 GSE126463_4_v_2_arid2_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_BE2C_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LOUNH91 DepMap CRISPR Gene Dependency 1.0 2.81882 Translation initiation complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.601 Endocardium disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.26 GTEX-NPJ7-0011-R2a-SM-2I3GF GTEx Tissue Sample Gene Expression Profiles -1.0 -0.950122 BHLHE40 ENCODE Transcription Factor Targets 1.0 null heart_6a HPA Tissue Sample Gene Expression Profiles -1.0 -0.991541 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FA-45-PN48_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231701 GRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05045 CEBPB_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null anterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.63215 GSE163052,GSE163198_5_v_8_hira_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A Rummagene Transcription Factor Associations 2026 1.0 null GTEX-TMMY-0426-SM-33HBB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.933846 medial mammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51021 Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of r1Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10805 cytoplasm LOCATE Predicted Protein Localization Annotations 1.0 null OC-314 COSMIC Cell Line Gene Mutation Profiles 1.0 null PBX3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ED-71-GA72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.355487 hypertension GWASdb SNP-Disease Associations 1.0 0.511996 NCOA3 Pathway Commons Protein-Protein Interactions 1.0 null Uterine adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.648 GSE202434,GSE202438_4_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4419b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null EBF1 ENCODE Transcription Factor Targets 1.0 null GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -2.02258 DD-74-PJ26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.368127 POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null developmental maturation GO Biological Process Annotations 2015 1.0 null H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41Q-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAD21_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCOF1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T5JC-0226-SM-32PMA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.891478 EGR1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE162892_4_v_5_isox_human RummaGEO Drug Perturbation Signatures 1.0 null HDAC2_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE160817_3_v_8_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_16792_KD_SPIB_SRP124308 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.91036 GSE199538,GSE199539_2_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49344 RPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19828 smoothmuscle_8b HPA Tissue Sample Gene Expression Profiles -1.0 -0.853473 GTEX-W5WG-1426-SM-4KKZP GTEx Tissue Sample Gene Expression Profiles 1.0 0.995466 GSE233679_6_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null Anterior hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.12802 BT-483 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.831984 GSE126463_5_v_2_arid2_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.513 ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.048128 DF-00-BX35_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.2491 mrna polyadenylation GO Biological Process Annotations 2015 1.0 null RBM25 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RM2N-1626-SM-2TF5N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27916 MTA2 Pathway Commons Protein-Protein Interactions 1.0 null GSE163240_3_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ8-2526-SM-2HML8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.33578 poly(A) binding GO Molecular Function Annotations 2023 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-7223-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null FOXI1-33610681-GES1-HUMAN-GASTRIC-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null GTEX-SIU8-0626-SM-2XCDN GTEx Tissue Sample Gene Expression Profiles 1.0 1.50685 GSE224131_5_v_1_mafb_human RummaGEO Gene Perturbation Signatures -1.0 null PBX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0524 FOXP2 ENCODE Transcription Factor Targets 1.0 null GSE233679_12_v_7_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QVUS-2926-SM-3GIJB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828563 20220088-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45W-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Precommissural nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0566 hmc1 HPA Cell Line Gene Expression Profiles -1.0 -1.20499 H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BL5519 (PCNT) NURSA Protein Complexes 1.0 null CTCF_fibroblast of mammary gland_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer SZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07339 GTEX-OIZH-2026-SM-3NB1M GTEx Tissue Sample Gene Expression Profiles 1.0 1.03659 H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDT8-3026-SM-32PKB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00775 VMRC-LCD Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.14235 RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.32033 ventrolateral prefrontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.23825 myb_16205643_primary_monocytes_gof_human_gpl570_gse2816 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.063861 GTEX-WFG8-0626-SM-3GILJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11363 Lung squamous cell carcinoma_LUSC_TCGA-85-8352-01A-31R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-NPJ8-2626-SM-2D7W2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.980057 Skin Cutaneous Melanoma_SKCM_TCGA-FR-A729-06A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null locus ceruleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.843496 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE221327_4_v_2_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null U937 CCLE Cell Line Gene Expression Profiles -1.0 -1.7602 DA-33-BM26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.12919 GTEX-RNOR-2426-SM-48FDY GTEx Tissue Sample Gene Expression Profiles 1.0 1.00455 KA-75-LP02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.642097 CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPLP0 Pathway Commons Protein-Protein Interactions 1.0 null TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K20me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PLZ4-0926-SM-2S1OI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.825324 primary somatosensory cortex (area S1, areas 3,1,2)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.855039 internal cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19348 claustrum, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.992234 Lower epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.324 GTEX-XV7Q-0326-SM-4BRVM GTEx Tissue Sample Gene Expression Profiles 1.0 1.59927 SSR1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_7948_KD_SKIIP_SRP155347 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.48637 PB-09-OE00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.775251 X-linked deafness 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.101 GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal oocyte morphology MGI Mouse Phenotype Associations 2023 1.0 null GTEX-QDVJ-0426-SM-2I5FW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827557 rostral periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08097 extracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rectal Mucosa Donor 31 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.04147 VD-88-MW70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.794629 intermediate (interpositus) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.46599 CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEC59_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 5.56191 rna processing GO Biological Process Annotations 2015 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4723-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE190384,GSE190386_2_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null 15273739-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null shell of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07521 KPL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.833316 GSE221327_5_v_9_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null dentate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.954234 CTCF_retinal pigment epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MN-1226-SM-3NMA5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16377 LMSU_STOMACH CCLE Cell Line Proteomics 1.0 5.06921 inner SZ in midlateral extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.04974 H3K4me3_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null ZBTB7A ENCODE Transcription Factor Targets 1.0 null H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-Q3-AA2A-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-V955-0426-SM-3GAEL GTEx Tissue Sample Gene Expression Profiles 1.0 1.30115 superficial stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04023 PBX-27287812-CHIP-SEQ-EMBYONIC-LIMB-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ZBTB7A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211151_1_v_4_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null EC-98-KI28_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.246279 GSE165548_2_v_4_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null SNG-M COSMIC Cell Line Gene Mutation Profiles 1.0 null poly-pyrimidine tract binding GO Molecular Function Annotations 2025 1.0 null GTEX-R53T-0526-SM-3GADL GTEx Tissue Sample Gene Expression Profiles 1.0 2.05067 LOVO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null PRKX CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04508 GSE232944_1_v_0_ctnnb1_human RummaGEO Gene Perturbation Signatures -1.0 null MAZ ENCODE Transcription Factor Targets 1.0 null GSE209582_1_v_2_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null TAF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A4MU-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null P300-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null AA-52-JS03_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232952 DSCC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.41824 GSE189834,GSE189836_1_v_0_brd4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE99187_1_v_0_gemcitabine_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AE-95-UU45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.562213 H3K4me1_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z2-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CWC27 Pathway Commons Protein-Protein Interactions 1.0 null VMRCLCD CCLE Cell Line Gene CNV Profiles -1.0 -2.34379 PMC8047323-Table_2.xlsx-LPS_PMMA_T24-GeneSymbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_366_KD_ARID1A_SRP198293 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.71776 SKMG1 DepMap CRISPR Gene Dependency 1.0 4.8377 reuniens nucleus (medioventral nucleus) of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.32644 CTCF_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gigantocellular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.853984 GSE180200,GSE180201_3_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-X4XY-1626-SM-46MVN GTEx Tissue Sample Gene Expression Profiles 1.0 1.30964 GTEX-S341-1526-SM-4AD6K GTEx Tissue Sample Gene Expression Profiles 1.0 1.04518 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.60098 Neurotoxicity Syndromes CTD Gene-Disease Associations 1.0 1.17202 YY1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRF1 ENCODE Transcription Factor Targets 1.0 null abnormal female reproductive system morphology MPO Gene-Phenotype Associations 1.0 null Cells - Cultured fibroblasts GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.706231 primary motor cortex (area M1, area 4)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.855039 Rif1_KD_GDS4943_243_mouse_F1 embryonic stem cell (ESCs) line GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null hsa-miR-330-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13498 CAPRIN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37398 FTC133 CCLE Cell Line Gene Expression Profiles -1.0 -1.52772 LOUNH91 CCLE Cell Line Gene Expression Profiles -1.0 -2.28319 Skeletal system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.1 Heterochromatin island COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.55 Lung adenocarcinoma_LUAD_TCGA-86-8673-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX3 ENCODE Transcription Factor Targets 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1693 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10674 GSE139455_7_v_6_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null KA-75-LP02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.4237 Nemaline myopathy 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.496 PSN1 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Secondary oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.234 VZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.77954 GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.13222 CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF7_Pracinostat_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00893835 OFD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10484 Brain Lower Grade Glioma_LGG_TCGA-DU-A6S8-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12764 Lymph node TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.31 abnormal cell physiology MPO Gene-Phenotype Associations 1.0 null JURLMK1 DepMap CRISPR Gene Dependency 1.0 2.95804 NCI-H1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.20623 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ND-39-PO34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.247176 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTNNB1 Pathway Commons Protein-Protein Interactions 1.0 null GSE206226_2_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.175156 TD-17-NF32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.318036 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-V1-A8WV-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8185471-mmc4.xlsx-D2-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_2_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15 Rummagene Transcription Factor Associations 2026 1.0 null Polyadenylate binding protein, human types 1, 2, 3, 4 InterPro Predicted Protein Domain Annotations 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2197 H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WYBS-1926-SM-3NM8N GTEx Tissue Sample Gene Expression Profiles 1.0 1.30283 Perturb_3896_KD_VprBP_SRP328755 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 CHL1 CCLE Cell Line Gene CNV Profiles -1.0 -1.80615 FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null outer SZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19897 tissues GeneRIF Biological Term Annotations 1.0 null extracellular region part GO Cellular Component Annotations 2015 1.0 null GSE176555,GSE176556_1_v_0_acriflavine_human RummaGEO Drug Perturbation Signatures 1.0 null GALE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37694 GTEX-UTHO-2426-SM-4JBHD GTEx Tissue Sample Gene Expression Profiles 1.0 1.56692 HUH6 DepMap CRISPR Gene Dependency 1.0 2.81784 KDM5B ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MB-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.128 BD-49-MD69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.08396 496100353_HIP_no dementia_TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.09186 periventricular stratum of PPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93322 TBP ENCODE Transcription Factor Targets 1.0 null Perturb_8382_KO_MEF2D_SRP165147 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 DB-21-FY75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.04598 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.822 hsa-miR-655 TargetScan Predicted Conserved microRNA Targets 1.0 0.568687 BC-40-TU13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.09905 GTEX-QV31-0726-SM-3GAEG GTEx Tissue Sample Gene Expression Profiles 1.0 0.906864 GTEX-WFON-2326-SM-3LK7M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50124 JA-63-WB39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.217544 developmental process involved in reproduction GO Biological Process Annotations 2015 1.0 null GTEX-WL46-0126-SM-3TW8I GTEx Tissue Sample Gene Expression Profiles 1.0 1.15981 GSE101112_6_v_4_j147_mouse RummaGEO Drug Perturbation Signatures -1.0 null CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6369 GTEX-PSDG-0726-SM-2I5FN GTEx Tissue Sample Gene Expression Profiles 1.0 1.67263 iPS-20b Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.12112 H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null layer 5 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09343 CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1 MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ in caudal cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.00382 YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Supratrigeminal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24848 EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MED13 Pathway Commons Protein-Protein Interactions 1.0 null r2 part of principal trigeminal sensory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22546 GTEX-QV44-2026-SM-2S1RD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44898 IST-MES1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.77595 GTEX-U3ZH-0926-SM-4DXU4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.25986 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE236437_0_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null BCL3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217552_3_v_5_fisetin_human RummaGEO Drug Perturbation Signatures -1.0 null EGFR_druginhibition_82_GSE27638 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.26789 lateral septal nucleus, intermedio-ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12742 GSE195663_7_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null r3 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.07041 Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NN-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null oocytes GeneRIF Biological Term Annotations 1.0 null GTEX-XUZC-2126-SM-4BRW8 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.12311 NCI-H196 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-OIZI-0226-SM-2XCEE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.857599 Central precocious puberty DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.031 BL5638 (AKAP13) NURSA Protein Complexes 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5888-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE126776_2_v_1_pelp1_human RummaGEO Gene Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-46-6026-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MED16 Pathway Commons Protein-Protein Interactions 1.0 null ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.70503 periventricular stratum of r4Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.5692 CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lingula (I) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.84284 Germ plasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.246 SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HT144 DepMap CRISPR Gene Dependency 1.0 2.39941 SP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33025 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TY-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PML_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rostral division of OFCi (area 11) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.835611 GSE163275_1_v_0_irf8_human RummaGEO Gene Perturbation Signatures -1.0 null primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.46627 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45U-01A-12R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X261-0011-R11A-SM-4E3JY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01716 RAD21_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null shell of T-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43869 BC-61-BE07_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.46172 H3K4me1_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null developmental process GO Biological Process Annotations 2015 1.0 null GSE176008_4_v_1_azacitidine_human RummaGEO Drug Perturbation Signatures 1.0 null UA-39-TN76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.281173 ENPP4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01691 GTEX-PX3G-0326-SM-2I3EO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24922 GTEX-NL3H-0011-R2a-SM-2I3GG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.832867 GSE202434,GSE202438_7_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null mammillary part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20228 SKNMC_BONE CCLE Cell Line Proteomics 1.0 2.34357 GSE128333_4_v_1_tcf4_human RummaGEO Gene Perturbation Signatures 1.0 null PMC12673788-12967_2025_7484_MOESM5_ESM.xlsx-OCT4_cor_p_0_4-gene_name_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null Zfp335 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.4762 GTEX-TSE9-0626-SM-3DB8B GTEx Tissue Sample Gene Expression Profiles 1.0 2.51205 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EEF1A2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77865 intermediate stratum of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18614 GSE202434,GSE202438_4_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1482 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.10281 GSE147240_3_v_7_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null LNZ308 CCLE Cell Line Gene Expression Profiles -1.0 -1.45393 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54446 GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.698 CB-16-SY72_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.505069 TM31 CCLE Cell Line Gene CNV Profiles -1.0 -1.43261 H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SELENOM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41057 FOXD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2635 H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Dorsal fin TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.517 HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.774148 GLRX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45928 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.2806 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE95077_1_v_2_amiloride_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QDT8-0526-SM-3NMD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05821 GTEX-OHPM-1626-SM-2HMK4 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.48824 GTEX-OXRK-1826-SM-2HMJE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.04216 Granular lamina of the cochlear nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21364 CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Lomustine_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0157074 RPF2 Pathway Commons Protein-Protein Interactions 1.0 null inner SZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.07977 SIN3A Pathway Commons Protein-Protein Interactions 1.0 null rostral interpeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18656 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42935 GTEX-XUZC-1626-SM-4BRVP GTEx Tissue Sample Gene Expression Profiles 1.0 0.871949 female infertility MGI Mouse Phenotype Associations 2023 1.0 null TBX4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.2745 SW982 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me1_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A9WI-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P4PQ-0326-SM-2HMJ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29988 Dinoflagellate cingulum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.791 SW 620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.54449 ACTN3 Pathway Commons Protein-Protein Interactions 1.0 null MRPS21 Pathway Commons Protein-Protein Interactions 1.0 null GSE195559_3_v_7_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of r1Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11785 abnormal ovary morphology MPO Gene-Phenotype Associations 1.0 null Perturb_339_KD_EIF4A1_SRP072285 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.31909 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70K-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mature GeneRIF Biological Term Annotations 1.0 null Amastigote TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.85 GSE228263_0_v_1_elesclomol_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.81409 Lens fiber TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.258 CEBPB_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WEY5-0426-SM-3GIKT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0509 GSE239688_4_v_3_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.346474 PMC8844187-Table_2.xlsx-prostate-DLX1_DLX1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null poly-purine tract binding GO Molecular Function Annotations 2023 1.0 null GSE120612_6_v_0_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PW2O-1226-SM-48TCH GTEx Tissue Sample Gene Expression Profiles 1.0 0.951205 Perturb_14181_KD_HOXBAS3_SRP222971 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -9.07421 periventricular stratum of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22905 JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS766T COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 MYB ChEA Transcription Factor Targets 1.0 null GTEX-WFG8-2426-SM-3GILL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.82236 Aliskiren_BT-474 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00452762 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V1-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE121866_0_v_2_six4_human RummaGEO Gene Perturbation Signatures 1.0 null HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null AC-30-XU83_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.674489 membrane-bounded vesicle GO Cellular Component Annotations 2015 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PL-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE239578_0_v_4_cxadr_mouse RummaGEO Gene Perturbation Signatures -1.0 null Palisade parenchyma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.021 ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GNB3 Pathway Commons Protein-Protein Interactions 1.0 null BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AP2B1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39947 Lung squamous cell carcinoma_LUSC_TCGA-43-7656-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TSE9-0326-SM-3DB82 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.83538 H3K79me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null metaphase GeneRIF Biological Term Annotations 1.0 null DAUDI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE164874_5_v_14_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HY-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null heterocycle metabolic process GO Biological Process Annotations 2015 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null GSE182680,GSE182683_5_v_9_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GSE127790_6_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE125219,GSE125221_4_v_2_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null Central nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.001 H4K91ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HT-144 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 KYSE-520 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 496100403_TCx_probable Alzheimer's disease_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.02692 GSE240645_3_v_2_u90926_mouse RummaGEO Gene Perturbation Signatures -1.0 null HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.36453 H3K27ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null k562clones TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.546 SUM 1315M02 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.21078 HDAC2_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE190316,GSE190324_1_v_9_rbm4_human RummaGEO Gene Perturbation Signatures 1.0 null XB-53-OZ95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.23481 H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.32821 NCI-H2228 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.975473 CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null TE-8 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles -1.0 -2.2355 TRIOBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07243 DOK COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE234514,GSE234516_1_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OXRL-1626-SM-2YUMU GTEx Tissue Sample Gene Expression Profiles -1.0 -2.10291 CTCF_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POYW-0526-SM-2XCEY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856338 PTBP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09031 MDAMB361 DepMap CRISPR Gene Dependency 1.0 2.02546 CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128730_7_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null abnormal secondary ovarian follicle morphology MPO Gene-Phenotype Associations 1.0 null GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52729 ACAD11 Pathway Commons Protein-Protein Interactions 1.0 null Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.336 NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hey Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.99463 cerebellar cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.836873 CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null decreased ovulation rate MPO Gene-Phenotype Associations 1.0 null dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.99217 IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJHI-1226-SM-4IHLR GTEx Tissue Sample Gene Expression Profiles 1.0 1.24033 H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HEK293_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null somatic GeneRIF Biological Term Annotations 1.0 null Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71137 GTEX-XUJ4-0526-SM-4BOON GTEx Tissue Sample Gene Expression Profiles -1.0 -0.895105 HSPA8 Pathway Commons Protein-Protein Interactions 1.0 null poly(U) RNA binding GO Molecular Function Annotations 2025 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HF-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null increased secondary ovarian follicle number MGI Mouse Phenotype Associations 2023 1.0 null CTCF_GM06990_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MED14 Pathway Commons Protein-Protein Interactions 1.0 null PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3A-Down_Dpy30_KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null EVSAT CCLE Cell Line Gene Expression Profiles -1.0 -3.15436 GSE231799_2_v_1_nfkbie_mouse RummaGEO Gene Perturbation Signatures -1.0 null ANKRD49 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38379 NCI-H2085 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.565 H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XXEK-0926-SM-4BRWH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08572 tonsil_8e1 HPA Tissue Sample Gene Expression Profiles 1.0 0.905863 GSE130246_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE127790_9_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null CC-04-WK34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.207188 Cytoplasmic ribonucleoprotein granule COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 CEBPD ENCODE Transcription Factor Targets 1.0 null MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-WQ-A9G7-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BTF3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27667 PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-PHF1_mod_PHF1 Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_305_KD_Pabpn1_SRP318863 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3 Rummagene Transcription Factor Associations 2026 1.0 null EZH2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A71R-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WH7G-1726-SM-4LVKY GTEx Tissue Sample Gene Expression Profiles 1.0 0.868108 PARK2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-Q2AG-0011-R9A-SM-2HMJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19908 TWF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32464 SUM159PT DepMap CRISPR Gene Dependency 1.0 4.04799 HT1197_URINARY_TRACT CCLE Cell Line Proteomics 1.0 5.75659 JURLMK1 CCLE Cell Line Gene Expression Profiles 1.0 1.7699 POLR2AphosphoS5_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARID3A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE118077_1_v_8_sprr5_human RummaGEO Gene Perturbation Signatures 1.0 null WHSC1 ENCODE Transcription Factor Targets 1.0 null 496100518_HIP_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.60216 H3K4me3_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H4K20me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC10933424-41420_2024_1903_MOESM1_ESM.pdf-277-ZNF256_ZNF256 Rummagene Transcription Factor Associations 2026 1.0 null TEAD4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF Rummagene Transcription Factor Associations 2026 1.0 null SU8686 CCLE Cell Line Gene Expression Profiles 1.0 2.16739 HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14101 Pole plasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.279 Ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.702 dorsofrontal pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.409 rostral division of VL Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.888832 AOB, mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26064 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.92287 GTEX-UPIC-0726-SM-3GADW GTEx Tissue Sample Gene Expression Profiles 1.0 0.872288 SERBP1 Pathway Commons Protein-Protein Interactions 1.0 null inferior olive, dorsal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08994 Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A66T-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Perturb_11400_KD_ECI2_SRP066238 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.68325 BHY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.888536 mantle zone of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10987 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE160304,GSE163392_2_v_3_zswim8_human RummaGEO Gene Perturbation Signatures 1.0 null Oocyst TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.725 SNU407 CCLE Cell Line Gene Expression Profiles -1.0 -1.52137 Male infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.231 ECC12 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE195559_8_v_7_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null NE-20-WM78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.810973 RPL23A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.4706 GSE131649_6_v_8_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null substantia innominata, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02896 striatum_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.66078 NFYB_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF384 ENCODE Transcription Factor Targets 1.0 null Bcl11b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 24.2249 CE-95-YX02_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.354616 primary auditory cortex (core)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.883876 VZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.33367 inner SZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.83794 GSE201309_4_v_2_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-VUSG-1726-SM-4KKZL GTEx Tissue Sample Gene Expression Profiles 1.0 1.34056 OCI-LY-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE180200,GSE180201_15_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE206270_1_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null Hmga1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.119 HEC251 DepMap CRISPR Gene Dependency 1.0 3.37295 layer 3 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09071 RPMI-7951 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.981979 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CM-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_CH12.LX_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114883_1_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WRNIP1 ENCODE Transcription Factor Targets 1.0 null CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MR-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DE-73-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.267844 ventrolateral prefrontal cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02054 GTEX-SIU7-1626-SM-4BRUK GTEx Tissue Sample Gene Expression Profiles 1.0 1.58506 Arsenic CTD Gene-Chemical Interactions 1.0 null Dux JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.9074 abnormal ovulation MPO Gene-Phenotype Associations 1.0 null COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.93015 H3K4me1_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE114992,GSE114993_1_v_2_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null fasciola cinerea Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.18587 CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver Neoplasms CTD Gene-Disease Associations 1.0 1.18456 H3K4me1_CD4+ CD25int CD127+ Tmem Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Infertility DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.574 intermediate stratum of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.01987 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.70364 Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S32W-0726-SM-2XCBL GTEx Tissue Sample Gene Expression Profiles 1.0 1.44566 H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null Cytosolic large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.188 EE-98-PF86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.241264 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCM9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23407 NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.39638 GSE221327_5_v_0_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XMK1-0626-SM-4B65A GTEx Tissue Sample Gene Expression Profiles 1.0 1.02449 LASV_FML29 _4hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -3.30188 Perturb_7851_KD_XAB2_SRP193107 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 15.6758 BE-73-KD75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.287542 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 679 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.859917 GTEX-PWOO-0826-SM-48TCL GTEx Tissue Sample Gene Expression Profiles 1.0 0.853764 GSE242290_3_v_2_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11518656-ADHM-13-0-s002.pdf-38-SATB1_SATB1 Rummagene Transcription Factor Associations 2026 1.0 null superior colliculus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.899947 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.974417 H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27ac_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Ensembl_ID_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null NEDD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.42472 MED4 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-P4PQ-1626-SM-2HMKK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.988921 KMRC20_KIDNEY CCLE Cell Line Proteomics 1.0 2.81981 CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.43864 HD-51-KD29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.1698 CTCF_GM12865_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1975 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_WI38_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JW-1826-SM-3GAE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2319 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.72438 A253 COSMIC Cell Line Gene Mutation Profiles 1.0 null CEBPB_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null estradiol_homo sapiens_gpl570_gds3283 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZB-29-GC39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.433747 dorsal lateral geniculate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07296 MB-49-LL22_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.255741 outer SZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.860657 ovaries GeneRIF Biological Term Annotations 1.0 null ARPC2 Pathway Commons Protein-Protein Interactions 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RS-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JC-0011-R11A-SM-32PMB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841363 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4875-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OXRP-0326-SM-33HBJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.15079 K562_TMP195_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0159146 POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCLC-21H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.925489 Belinostat_SK-MEL-2 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.0131356 CTCF_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UMUC7 DepMap CRISPR Gene Dependency 1.0 5.86751 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2726-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GNB2L1 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_3_KO_Cnot6l_SRP152802 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.79956 PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null IPC-298 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.82174 SIN3A ENCODE Transcription Factor Targets 1.0 null extracellular vesicular exosome GO Cellular Component Annotations 2015 1.0 null GSE158632_3_v_5_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158834_7_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Colon Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KRI1 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_CD19 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Paraventricular hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.69872 TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-WK-A8XT-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BA-84-WN26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.532296 Perturb_14182_KD_HOXBAS3_SRP222971 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -5.9013 NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.01901 GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22028 GSE152441,GSE152442_6_v_2_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WHSE-0926-SM-3NMBS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06277 DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.217781 FTSJ3 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2896-03B-01T-0751-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE102870_3_v_9_nr1h4_human RummaGEO Gene Perturbation Signatures -1.0 null isthmic vestibulocerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57925 H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE195513_0_v_3_cpeb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of PHyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47076 CLCF1 Pathway Commons Protein-Protein Interactions 1.0 null Colorectal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.41 GSE201309_5_v_8_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE120756_2_v_9_tet2_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE148193_1_v_0_satb2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-SUCS-1426-SM-4DM5W GTEx Tissue Sample Gene Expression Profiles 1.0 0.84538 CTCF_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.052 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH838 CCLE Cell Line Gene CNV Profiles 1.0 1.41363 GTEX-W5X1-0426-SM-3GILB GTEx Tissue Sample Gene Expression Profiles 1.0 1.54497 GSE216273,GSE216292_14_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null Lobules IV-V, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04084 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HG-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular developmental process GO Biological Process Annotations 2015 1.0 null C32_SKIN CCLE Cell Line Proteomics 1.0 2.51717 head of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.972946 Ptosis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.988 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CHD7 ENCODE Transcription Factor Targets 1.0 null ZDHHC21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32011 POLR2A_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE140997_4_v_1_nsun6_human RummaGEO Gene Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GV-A40G-01A-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Disease of mental health DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.742 Econazole_SW480 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0201996 GSE206516,GSE206518_0_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null Bipolar disorder GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.8 HCC1143 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.13338 Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.12 Nervous System Diseases CTD Gene-Disease Associations 1.0 1.22599 Hyperplasia CTD Gene-Disease Associations 1.0 1.46356 poly-pyrimidine tract binding GO Molecular Function Annotations 2023 1.0 null BE-79-QU25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.377477 E2F6 ENCODE Transcription Factor Targets 1.0 null CCNYL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23451 HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_2_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47N-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3884 GTEX-X15G-0526-SM-3NMB7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18715 GSE167474_1_v_3_naa40_human RummaGEO Gene Perturbation Signatures -1.0 null CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2485 CEBPB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null subparafascicular nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2096 GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14875 PAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8996 dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00187 SP1 ENCODE Transcription Factor Targets 1.0 null ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQ7-1726-SM-2S1QQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20996 NCI-H1048 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.46326 large intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.405555 RXRA ENCODE Transcription Factor Targets 1.0 null GSE244710_3_v_0_srsf1_human RummaGEO Gene Perturbation Signatures -1.0 null PMC5195898-NIHMS825571-supplement-3.xlsx-Sheet1-H1975_M1_vs_H1975_M1_CIC_reconstitution_Differential_gene_expression_CIC Rummagene Transcription Factor Associations 2026 1.0 null RAD21_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null DLGAP4 Pathway Commons Protein-Protein Interactions 1.0 null BRCA1 ENCODE Transcription Factor Targets 1.0 null MCF7_Busulfan_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0138109 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S33H-1826-SM-4AD65 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17247 organic cyclic compound binding GO Molecular Function Annotations 2015 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A7AZ-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KASUMI1 DepMap CRISPR Gene Dependency 1.0 2.41168 GSE229671,GSE229673_0_v_1_yrdc_human RummaGEO Gene Perturbation Signatures 1.0 null Periventricular zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35257 C32 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.998378 SCC4 DepMap CRISPR Gene Dependency 1.0 2.36981 GTEX-WHPG-0826-SM-3NMBF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11138 CAOV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.975924 GA-04-JM33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.206437 EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36169 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4988-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cecum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.204 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null LARS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3869 ASB2 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_Chondrocytes from Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-XBEW-0126-SM-4AT66 GTEx Tissue Sample Gene Expression Profiles 1.0 1.68662 caudal group of intralaminar nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.90962 MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FF-28-ES17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.415785 RAD21_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8405683-41419_2021_4120_MOESM2_ESM.xlsx-Sheet1-Table_S2_MYCN-responsive_gene_list_1_5_fold_p_0_05_MYCN Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cholesterol ester storage disease GWASdb SNP-Disease Associations 1.0 0.757675 SH3BP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01242 GSE163240_2_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Large ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.103 H3K18ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE60217_1_v_8_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GA-81-DL34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.521308 intermediate stratum of isLim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08097 RAD21_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal oogenesis MGI Mouse Phenotype Associations 2023 1.0 null GSE197630_1_v_0_ruvbl1_human RummaGEO Gene Perturbation Signatures 1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular aromatic compound metabolic process GO Biological Process Annotations 2015 1.0 null Sarcoma_SARC_TCGA-KF-A41W-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null rna binding GO Molecular Function Annotations 2015 1.0 null PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-SUPPLEMENTARY_TABLE_12_Bulk_RNA-seq_results_of_invasive_fractions_from_GBM43_CTH_knockdwn_vs_GBM43_control_cells_invading_3D_hydrogels_AR Rummagene Transcription Factor Associations 2026 1.0 null SW626 DepMap CRISPR Gene Dependency 1.0 7.22991 TBX20 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.6334 r1 part of superior vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10009 GSE211151_2_v_4_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null YY1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X585-0005-SM-46MV3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.82784 GSE154577_2_v_9_plagl1_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF-21964334-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.912271 Nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.113 PMC5967331-41467_2018_4384_MOESM4_ESM.xlsx-Sup_data1_with_CCF_txt-Gene_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SS-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEx AdiposeTissue 20-29 vs 70-79 GTEx Tissue-Specific Aging Signatures 1.0 5.25515 extracellular region COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 PE-82-OK78_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.32088 A-CA-04-2009(H1N1)_0Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.49527 GSE185519_4_v_7_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMRM-0726-SM-2I5G8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.90454 HCC2218 CCLE Cell Line Gene Expression Profiles -1.0 -2.17746 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-PN-A8MA-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIPA1L2 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AB-71-CI37_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206385 intermediate stratum of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5092 GSE227698_2_v_4_g0s2_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-W5WG-1926-SM-4KKZK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18772 CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null DM3 CCLE Cell Line Gene Expression Profiles -1.0 -1.5449 POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE126463_1_v_3_pomalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null TAGLN3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16051 BMT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23807 SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null DUS3L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20478 MYB-21317192-ERMYB-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-X8HC-0726-SM-46MWG GTEx Tissue Sample Gene Expression Profiles 1.0 1.65049 GABP-19822575-HEPG2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null VDR-23849224-CD4+-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNGM_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 4.74476 Necrosis CTD Gene-Disease Associations 1.0 1.65271 PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_9986_KD_U2AF2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 11.931 CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRPF31 Pathway Commons Protein-Protein Interactions 1.0 null Left_Ventricle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.38435 Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.074 PMC10894266-42003_2024_5898_MOESM9_ESM.xlsx-EPC_siCTL_vs_EPC_SMAD1-5_Sample-gene_id_SMAD1 Rummagene Transcription Factor Associations 2026 1.0 null MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE142684_4_v_7_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8514-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FMR1 Pathway Commons Protein-Protein Interactions 1.0 null JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28473 POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SU-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RELA JASPAR Predicted Transcription Factor Targets 1.0 null CDC16 Pathway Commons Protein-Protein Interactions 1.0 null GSE199204,GSE211619_4_v_2_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null GSE236437_2_v_3_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null Spermatid TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.33 Dentate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04618 H3K79me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_GM12873_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null VPS18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00319 extracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GSE208350_4_v_1_fgfr1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE126463_5_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null EGR1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF274 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.3973 G59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null a-USP9X (USP9X) NURSA Protein Complexes 1.0 null RBM10 Pathway Commons Protein-Protein Interactions 1.0 null Ebolavirus(ZEBOV)_1day_Liver_None_GSE57214 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.00644 FF-28-ES17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.292578 TBX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.4571 CTCF_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ACTN1 Pathway Commons Protein-Protein Interactions 1.0 null WM793B Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.64577 FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P78B-1826-SM-3P5YX GTEx Tissue Sample Gene Expression Profiles 1.0 1.02027 GSE158320,GSE183351_2_v_3_lin28b_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_astrocyte of the cerebellum_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-12-BM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14101 PMC8986528-41586_2022_4598_MOESM6_ESM.xlsx-Fig_4f-NOL9_KD_downreg_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HV-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KA-81-AG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.92491 GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59949 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050762 GSE206729_3_v_1_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6IJ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_11938_KO_SPI1_ERP119419 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.71278 FOSL2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FAM221A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00499 Kidney Chromophobe_KICH_TCGA-KO-8403-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC3636213-pgen.1003459.s012.xlsx-Sheet1-KD_3_AR Rummagene Transcription Factor Associations 2026 1.0 null bonemarrow_6b HPA Tissue Sample Gene Expression Profiles 1.0 1.20008 Lung adenocarcinoma_LUAD_TCGA-55-8092-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VC-01A-23R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE189683_3_v_0_rif1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Head kidney TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.593 REST ENCODE Transcription Factor Targets 1.0 null GTEX-WFJO-0226-SM-3GIKW GTEx Tissue Sample Gene Expression Profiles 1.0 1.51788 DMS-53 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.66933 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.841105 gastrointestinal tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.216325 MRPS2 Pathway Commons Protein-Protein Interactions 1.0 null GSE60217_1_v_2_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-A5C4-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMARCA5 Pathway Commons Protein-Protein Interactions 1.0 null PC-87-OG75_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.319 GSE171837_3_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0873 subthalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.74387 Mesothelioma_MESO_TCGA-TS-A7P0-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HS 675.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE112365_0_v_1_sirt1_human RummaGEO Gene Perturbation Signatures 1.0 null Liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEC-1-B cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.837 LMO2-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Paraventricular hypothalamic nucleus, parvicellular division, medial parvicellular part, dorsal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56005 GSE57871_6_v_9_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Lung Neoplasms CTD Gene-Disease Associations 1.0 1.15661 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RPL17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.46137 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UM-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null interpositus (intermediate) nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.56082 Paraspeckles COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.851 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AU-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMC4-20622854-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.859 subcuneiform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02666 ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AF-99-HA02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.284759 NBPF8 Pathway Commons Protein-Protein Interactions 1.0 null GSE202434,GSE202438_10_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GF-35-IT27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.330045 ATM_01_219 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 1.5258 amygdalohippocampal transition zone, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.977803 Prostate adenocarcinoma_PRAD_TCGA-KK-A59V-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer IIIu of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.17719 medial part of the lateral habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03474 abnormal ovarian follicle morphology MGI Mouse Phenotype Associations 2023 1.0 null GTEX-XGQ4-0326-SM-4GIEE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.957028 GTEX-RUSQ-1026-SM-2TF6V GTEx Tissue Sample Gene Expression Profiles 1.0 1.42387 CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ophthalmoplegia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.41 mammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45245 r1 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30112 GSE92614_1_v_0_pten_mouse RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TA-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE200839,GSE233826_2_v_0_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null SND1 Pathway Commons Protein-Protein Interactions 1.0 null PAN complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.581 pterigoid muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.75585 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.829055 P granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.073 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.27895 MX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.48438 GSE211215_1_v_0_pemetrexed_human RummaGEO Drug Perturbation Signatures 1.0 null RAD21 ENCODE Transcription Factor Targets 1.0 null IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.690349 G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24132 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4T6-01A-32R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-IF-A4AJ-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EFO-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.27088 H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GSE233049_2_v_0_atf3_human RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PRKDC Pathway Commons Protein-Protein Interactions 1.0 null Dcp1-Dcp2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.784 DNTTIP1 Pathway Commons Protein-Protein Interactions 1.0 null SVEC4-10 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.757 Perturb_5642_KD_SOX2_SRP174102 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-XAJ8-1026-SM-47JY9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06031 Rectum adenocarcinoma_READ_TCGA-DY-A1H8-01A-21R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6VB-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8IK-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of r3Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47322 YWHAH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01931 mediodorsal nucleus of thalamus_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.876402 vesicle GeneRIF Biological Term Annotations 1.0 null GTEX-WL46-0011-R11A-SM-3MJFT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.978791 ITM2B-related cerebral amyloid angiopathy 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.103 PMC4686761-ncomms10068-s3.xlsx-S2G-MSC_down_specific-Supplementary_Data_2G_-_expression_of_down-regulated_genes_2_fold_change_specifically_in_MSC_PTEN-_-_vs_MSC_PTEN_MSC Rummagene Transcription Factor Associations 2026 1.0 null MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A680-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OF-05-CB18_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.913518 Prostate adenocarcinoma_PRAD_TCGA-YL-A8SO-01B-31R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BC-61-ZY95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.256135 GTEX-UJMC-1826-SM-3GADT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68103 GTEX-T2IS-0011-R11A-SM-32QPC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1007 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Adductor magnus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.783 Neuronal ribonucleoprotein granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.959 NCI-H2444 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 SA-32-CC58_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.298473 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null H3K27ac_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null central gray of the pons, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.19016 hsa-miR-374c TargetScan Predicted Conserved microRNA Targets 1.0 0.632343 nucleus GO Cellular Component Annotations 2025 1.0 null Primary oocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.254 DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.64004 GTEX-XQ3S-2526-SM-4BOOG GTEx Tissue Sample Gene Expression Profiles 1.0 0.956424 medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.33984 POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVSAHO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.888536 medial ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.26821 GTEX-XLM4-0726-SM-4AT64 GTEx Tissue Sample Gene Expression Profiles 1.0 1.52691 KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.84503 LY-2584702 (tosylate salt)_BT-474 Tahoe Therapeutics Tahoe 100M Perturbation Atlas -1.0 -0.012037 GTEX-R55E-0826-SM-2TC5M GTEx Tissue Sample Gene Expression Profiles 1.0 0.972189 CTCF_GM12865_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80884 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29985 r1 part of vestibular sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11785 FU97 CCLE Cell Line Gene CNV Profiles 1.0 1.55638 ATG2A Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QDT8-0011-R11A-SM-32PKD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.914614 primary auditory cortex (core)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03426 H3K4me3_Treg Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null dorsolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.46248 NCI-H1650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20914 THAP1 ENCODE Transcription Factor Targets 1.0 null superficial stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24384 Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.66496 GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78877 HCC1569 CCLE Cell Line Gene CNV Profiles 1.0 2.06565 ventral premammillary nucleus (migrated) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56642 chr20_44904645_T_G_b38 GTEx eQTL 2025 1.0 1.57117 496100349_HIP_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.07145 FOXA2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BD-25-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.269144 KYSE520 CCLE Cell Line Gene CNV Profiles 1.0 1.38643 POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE182680,GSE182683_5_v_6_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS16 Pathway Commons Protein-Protein Interactions 1.0 null NEUROD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7599 BCPAP CCLE Cell Line Gene CNV Profiles 1.0 1.52545 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.94055 SMC1A Pathway Commons Protein-Protein Interactions 1.0 null VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.968979 abnormal gland morphology MPO Gene-Phenotype Associations 1.0 null GTEX-SNMC-0926-SM-4DM5U GTEx Tissue Sample Gene Expression Profiles 1.0 0.904617 Lung adenocarcinoma_LUAD_TCGA-55-8085-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K79me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OVMANA CCLE Cell Line Gene Expression Profiles 1.0 1.5909 GSE216274,GSE216292_4_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null red nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08212 KMS-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.37538 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6945-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in midcingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01628 GTEX-QDVN-0626-SM-2I3FP GTEx Tissue Sample Gene Expression Profiles 1.0 1.08494 nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.31595 CTCF_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HW-A5KK-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null icSARA deltaORF6_7Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.43448 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ACHN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.871091 Posterolateral visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40113 GTEX-XMD1-0826-SM-4AT52 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07053 TRIM24 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-OOBJ-0926-SM-48TDO GTEx Tissue Sample Gene Expression Profiles 1.0 0.935068 GTEX-V1D1-0726-SM-4JBH7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.44633 OB-17-DQ74_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.647708 JE-72-KV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.487612 Neurod2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.961 BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.46097 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Ocular motility disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.291 GSE86507,GSE86509_3_v_8_hoxb7_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZEB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.48615 GSE178292_0_v_1_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null ETS2 MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.74948 magnocellular diagonal band nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.95433 parvicellular part of Lat Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21733 TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Plagl1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.754 GSE171572_5_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null GNL2 Pathway Commons Protein-Protein Interactions 1.0 null SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RVPU-0011-R9A-SM-3NM8E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34302 RPS4X Pathway Commons Protein-Protein Interactions 1.0 null Polysomal ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.521 single-stranded DNA-binding protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.781 HCFC2 Pathway Commons Protein-Protein Interactions 1.0 null GSE158834_10_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null COPZ1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.36343 EGR1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null peduncular part of dorsomedial hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.74284 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_2_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE244710_1_v_2_srsf1_human RummaGEO Gene Perturbation Signatures -1.0 null DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.25467 CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.414 CCNT2 ENCODE Transcription Factor Targets 1.0 null BC-25-VR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.499566 GTEX-S4P3-0226-SM-3K2BD GTEx Tissue Sample Gene Expression Profiles 1.0 1.55242 PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-Symbol_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null AA-48-XT80_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.330774 EC-07-AO30_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.263049 GSE158834_10_v_6_palm_human RummaGEO Gene Perturbation Signatures 1.0 null NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.839178 organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 LP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.863804 Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NM-01A-21R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intermediate stratum of r1Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30112 NOP56 Pathway Commons Protein-Protein Interactions 1.0 null Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part, lateral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7126 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4821-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_2-up-regulated_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null CUX1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MEL-24 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Epimastigote TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.632 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-V1-A8MG-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null p1 portion of the paranigral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05065 CTCF_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal reproductive system morphology MPO Gene-Phenotype Associations 1.0 null MGH-U4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.549 NFATC1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12055596-41375_2025_2570_MOESM4_ESM.xlsx-PDX1-Unnamed_14_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WYJK-1626-SM-3NM9J GTEx Tissue Sample Gene Expression Profiles 1.0 1.31304 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.968891 GTEX-WL46-0011-R10A-SM-3MJFQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860657 SA-32-CC58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.362172 AB-33-EM56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.363099 GSE200839,GSE233826_2_v_4_tnrc18_human RummaGEO Gene Perturbation Signatures -1.0 null female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Uterus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.033 dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04414 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.11573 MRPS27 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LARP1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84682 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FM-8000-01A-11R-2213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JE-55-OJ53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.205815 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TFAP4_01_295 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -4.72685 H3K27ac_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RCCFG2 DepMap CRISPR Gene Dependency 1.0 2.06291 ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mantle zone of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2026 H3K27me3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_9_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE146612_2_v_0_amiodarone_human RummaGEO Drug Perturbation Signatures -1.0 null H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Clear cell renal cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.229 GSE201309_5_v_7_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null 496100408_PCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.31395 H3K9ac_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE63857_3_v_1_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null EE-98-PF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.204639 C11orf71 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.64018 GTEX-P44H-0011-R11A-SM-2XCER GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23721 GTEX-S7SE-0011-R11A-SM-2XCDD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.830231 STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H460 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05689 DEOC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02857 primary motor cortex (area M1, area 4)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.933498 CNN1 Pathway Commons Protein-Protein Interactions 1.0 null small-subunit processome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.745 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE120612_4_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-QK-A6V9-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RERFGC1B DepMap CRISPR Gene Dependency 1.0 9.91546 Vaesbj TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.383 r4 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56835 outer CP in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08263 SNU869 CCLE Cell Line Gene CNV Profiles -1.0 -3.21049 GTEX-SE5C-0726-SM-4BRWY GTEx Tissue Sample Gene Expression Profiles 1.0 1.46294 GSE248887_0_v_1_dkk1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE255432_7_v_2_imeglimin_mouse RummaGEO Drug Perturbation Signatures 1.0 null YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02654 NCIH82 DepMap CRISPR Gene Dependency 1.0 2.55827 GSE227592_13_v_1_adar_human RummaGEO Gene Perturbation Signatures -1.0 null single-organism developmental process GO Biological Process Annotations 2015 1.0 null intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07059 LRRC47 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.2898 FLNC Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X4XX-0626-SM-3NMC1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.838952 Prostate adenocarcinoma_PRAD_TCGA-YL-A8S8-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AG-0011-R11A-SM-2HMKZ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849476 Ribonucleoprotein complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 GTEX-XUJ4-0726-SM-4BOOP GTEx Tissue Sample Gene Expression Profiles 1.0 0.941092 cellular process involved in reproduction in multicellular organism GO Biological Process Annotations 2015 1.0 null RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPS4Y1 Pathway Commons Protein-Protein Interactions 1.0 null Pt-K2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.0 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.54087 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A7IP-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EGR1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MED15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13513 GSE166315_5_v_3_docetaxel_mouse RummaGEO Drug Perturbation Signatures -1.0 null SLC7A6 Pathway Commons Protein-Protein Interactions 1.0 null H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBED-1226-SM-4AT5V GTEx Tissue Sample Gene Expression Profiles 1.0 0.842043 RMI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01529 Renal cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.215 RUSF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00291 GSE231799_2_v_5_nfkbie_mouse RummaGEO Gene Perturbation Signatures -1.0 null NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null RAD21_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_MCF-7_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null OAW28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.830617 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6347712-pnas.1812449116.sd06.xlsx-iPSC_IRF7_48h_rest_RNAExpress-Gene_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null lipid storage disease GWASdb SNP-Disease Associations 1.0 0.383074 Brain Lower Grade Glioma_LGG_TCGA-TM-A7C3-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4019 MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70O-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ovarian cumulus cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.612 K562_Celecoxib_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0144457 Biofilm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.337 CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-0426-SM-2S1PU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00799 Lung adenocarcinoma_LUAD_TCGA-MP-A4SV-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pellicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.934 USF2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_12741_KD_WDR5_SRP261594 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -13.3688 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r2 part of superior vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1527 HELF cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.522 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE173394_1_v_0_nfatc2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE197850_4_v_2_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-S4Q7-0326-SM-3K2B1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.827508 MEL-HO Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.00524 DNAJC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02073 MCAS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.974796 Fibrosis CTD Gene-Disease Associations 1.0 1.19345 GTEX-OXRL-0008-SM-3NB29 GTEx Tissue Sample Gene Expression Profiles 1.0 0.909527 hsa-miR-4446-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 S0-EE-XMXE_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.38967 GTEX-OHPN-0011-R11A-SM-2I5FM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0849 SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.25008 intermediate stratum of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27945 CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NUGC2 CCLE Cell Line Gene CNV Profiles 1.0 1.51735 POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWCY-2326-SM-2I3EQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.858305 EIF4E2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33836 CLASP2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76483 Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12878_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.17349 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4992-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RTCB Pathway Commons Protein-Protein Interactions 1.0 null layer 3 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.09017 posteroventral (inferior) parietal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.939392 PMC10894266-42003_2024_5898_MOESM9_ESM.xlsx-EPC_siCTL_vs_EPC_SMAD1-5_Sample-symbol_SMAD1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-T6MN-0011-R11A-SM-32QOX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.882506 Lung squamous cell carcinoma_LUSC_TCGA-43-6143-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE80537_3_v_2_adhfe1_human RummaGEO Gene Perturbation Signatures -1.0 null H3118 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_340_KD_EIF4E_SRP072285 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 12.904 Perturb_16004_OE_HOXA13_SRP107176 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.48068 ZBTB21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25008 Temporal association areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.62675 hippocampus (hippocampal formation)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.08022 GSE206984_1_v_0_bortezomib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE182680,GSE182683_5_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.50184 SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null HS 766T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39357 nucleus GO Cellular Component Annotations 2023 1.0 null DAUDI COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KYSE140 CCLE Cell Line Gene CNV Profiles -1.0 -1.33595 Acute Myeloid Leukemia_LAML_TCGA-AB-2993-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H322T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.831032 CTCF_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-QQ-A8VB-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CA-75-HA22_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.51803 RPS3 Pathway Commons Protein-Protein Interactions 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7X8-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9980149-media-17.xlsx-Supp_Table_12_Bulk_Seq_CTH_KD_I-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null THAP1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-73-7498-01A-12R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU-175 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-VUSG-2226-SM-4KKZO GTEx Tissue Sample Gene Expression Profiles 1.0 0.911431 GSE128730_4_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null ONS-76 COSMIC Cell Line Gene Mutation Profiles 1.0 null HCoV-EMC2012_7Hour_23631916_GSE45042 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.04685 FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T5JC-0626-SM-3NMA6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3978 poly(A) binding GO Molecular Function Annotations 2025 1.0 null PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE60217_1_v_7_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-TSE9-2926-SM-3DB77 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.978286 GSE151494_8_v_3_nrp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Preribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.765 Muscular disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.79 Female germ cell nucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.951 Dorsomedial nucleus of the hypothalamus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.52073 GSE103068_0_v_7_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null amygdaloid complex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.965351 Prostate adenocarcinoma_PRAD_TCGA-VP-A87B-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17169 C2BBE1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney - Medulla GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.08273 POLR2A ENCODE Transcription Factor Targets 1.0 null DDX39A Pathway Commons Protein-Protein Interactions 1.0 null Perturb_16935_KD_SOX2_SRP286421 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 MBTPS2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39133 T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.43411 CTCF_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE214212_2_v_0_chd6_human RummaGEO Gene Perturbation Signatures -1.0 null Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.117 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.040314 central nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.27458 GTEX-WY7C-0526-SM-3NB3D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851764 NUGC-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.71525 Head muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.057 FOXA1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.76859 GTEX-NPJ8-2126-SM-3MJGK GTEx Tissue Sample Gene Expression Profiles 1.0 1.91795 GTEX-T2IS-0626-SM-32QP6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.60281 GTF3C1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-P78B-1626-SM-2S1O1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72399 DDX41 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XBEC-1526-SM-4AT68 GTEx Tissue Sample Gene Expression Profiles 1.0 1.50883 HIST1H1C Pathway Commons Protein-Protein Interactions 1.0 null HCA-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H3K4me3_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-0826-SM-2HMK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00348 Lens nucleus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.909 GTEX-OXRL-2626-SM-2I3F1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11357 H3K79me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NPJ7-2826-SM-2I3FU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.947205 outer portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15621 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.6549 GTEX-P78B-0526-SM-2I5F7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.197 GTEX-NPJ8-0011-R11A-SM-2YUMS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.928838 AB-64-ZX70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.420736 NCIH1355 CCLE Cell Line Gene Expression Profiles -1.0 -2.32522 GTEX-WHSE-0011-R2A-SM-3P5ZL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860241 COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.49145 PMC9714459-DataSheet3.xlsx-Supplement_3A-1166_common_elements_in_MSC_and_Fibroblasts_MSC Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC4686057-pone.0145107.s001.xlsx-CAA-C-Unnamed_0_TSHZ1 Rummagene Transcription Factor Associations 2026 1.0 null HR Pathway Commons Protein-Protein Interactions 1.0 null FA-88-II68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.792009 Box C/D RNP complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.897 GSE215086_8_v_6_batf_human RummaGEO Gene Perturbation Signatures -1.0 null GSE152441,GSE152442_6_v_5_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_GM13976_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XBED-0126-SM-47JY7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.38389 H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5ZF-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cerebellar nuclei of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34878 TEAD4 ENCODE Transcription Factor Targets 1.0 null H3K79me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null paraventricular nucleus, cap part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93252 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_2_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null H3K27ac_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PMC9999213-mmc1.xlsx-DEGs_vs_2D-DEA_NB_MSC_EC_CSc_vs_NB_2D_MSC Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X5EB-0726-SM-46MVR GTEx Tissue Sample Gene Expression Profiles 1.0 1.17566 8MGBA DepMap CRISPR Gene Dependency 1.0 2.21003 ZFTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80705 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AD-51-FB60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201379 Econazole_BT-474 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00619156 H3K27ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EA-73-UC67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.278661 ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mantle zone of PHyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21555 RPL35 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.64211 SARC9371 COSMIC Cell Line Gene Mutation Profiles 1.0 null RPL29 Pathway Commons Protein-Protein Interactions 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A4MX-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdaloid complex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.41682 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AI-0526-SM-2I3EJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.14138 Perturb_12851_KO_Tet2_SRP338315 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.2441 EP300 ENCODE Transcription Factor Targets 1.0 null GTEX-U4B1-0626-SM-3DB8L GTEx Tissue Sample Gene Expression Profiles 1.0 1.4712 tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050664 GSE128730_4_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null Entorhinal area, medial part, dorsal zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10469 PMC8755441-mmc3.xlsx-IRF7-Up-ezh2_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRKRA Pathway Commons Protein-Protein Interactions 1.0 null ventral tegmental area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.892969 GTEX-WRHU-0826-SM-3MJFN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03075 SR-786 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.950951 GSE236228_0_v_1_penfluridol_human RummaGEO Drug Perturbation Signatures 1.0 null motor nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.871884 GSE207863_0_v_1_hdac5_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NUP37 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12615 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A4BB-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWOO-0926-SM-2I3EC GTEx Tissue Sample Gene Expression Profiles 1.0 1.6725 GSE171837_0_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null VIM Pathway Commons Protein-Protein Interactions 1.0 null Cholesterol, HDL dbGAP Gene-Trait Associations 1.0 0.124639 Pancreas Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.69527 r1 part of vestibulocerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17697 HMCB CCLE Cell Line Gene CNV Profiles -1.0 -1.78348 MITF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24531 H3K4me3_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null JE-04-LS32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.228263 GSE101239_5_v_6_valproic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null molecular_function GO Molecular Function Annotations 2015 1.0 null GSE122101,GSE122103_0_v_1_ssu72_mouse RummaGEO Gene Perturbation Signatures 1.0 null Muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.06 GSE235550_2_v_0_hspa9_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-NPJ7-2926-SM-3MJGQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.913931 PES1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-Q2AG-3026-SM-48U1L GTEx Tissue Sample Gene Expression Profiles 1.0 1.17013 GSE85302_0_v_1_kat6a_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PWOO-0626-SM-48TZH GTEx Tissue Sample Gene Expression Profiles 1.0 1.24374 thyroid_5a HPA Tissue Sample Gene Expression Profiles 1.0 2.9288 AC-74-ZA35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.311345 TF-77-DW08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.38967 KATNAL2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-TKQ1-1426-SM-4GICK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23292 FE-10-KQ78_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.576877 SF3B3 Pathway Commons Protein-Protein Interactions 1.0 null ESR2 Hub Proteins Protein-Protein Interactions 1.0 null Sapanisertib_BT-474 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0058595 PMC8812561-pnas.2110428119.sd11.xlsx-Sheet1-The_overlapping_genes_of_LCDR_KD_RNA-seq_hnRNP_K_KD_RNA-seq_hnRNP_K_RIP-seq_and_eCLIP-seq_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QEL4-0726-SM-3GIJ5 GTEx Tissue Sample Gene Expression Profiles 1.0 2.11579 GSE228430_1_v_3_fabp5_human RummaGEO Gene Perturbation Signatures 1.0 null mRNA 3'-UTR binding GO Molecular Function Annotations 2025 1.0 null 18794137-SuppTable1a GeneSigDB Published Gene Signatures 1.0 null CTCF_epithelial cell of proximal tubule_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ1-0126-SM-33HB3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11631 Perturb_961_KD_HOXBAS3_SRP222971 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.04677 GA-77-MH38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.268969 orbital frontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.928159 binding GO Molecular Function Annotations 2015 1.0 null GNAQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02363 NFIC ENCODE Transcription Factor Targets 1.0 null werirb1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.831 IRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Retrosplenial area, lateral agranular part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00335 T-84 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.96 small molecule binding GO Molecular Function Annotations 2015 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.965968 PML ENCODE Transcription Factor Targets 1.0 null BL4961 (ABI1) NURSA Protein Complexes 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4143-01A-01R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MED27 Pathway Commons Protein-Protein Interactions 1.0 null SARS-CoV_0Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.7747 MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE202434,GSE202438_10_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null NR1I2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.5287 GTEX-P4PP-1826-SM-2S1NT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.842914 RXRA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE231799_3_v_4_nfkbie_mouse RummaGEO Gene Perturbation Signatures -1.0 null GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null K562_Curcumin_10nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0158701 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M6-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU520 CCLE Cell Line Gene Expression Profiles -1.0 -1.54011 IGROV1_OVARY CCLE Cell Line Proteomics 1.0 2.99367 EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Retinoblastoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.668 GTEX-POMQ-0326-SM-2I5FO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35286 EGR1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-O1-A52J-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Girardiheart TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.952 IC-05-AW29_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.223496 POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.38002 MTA3 ENCODE Transcription Factor Targets 1.0 null MAX_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12069319-Table1.xlsx-OCAB_p40_BirA-Gene_Symbol_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null U2 snRNP COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.702 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleotide binding GO Molecular Function Annotations 2015 1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51632 MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-97-A4M1-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Supramammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00415 Lobules IV-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05663 Perturb_13951_KD_ASCL1_SRP201348 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CE-37-XI06_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237823 dorsolateral prefrontal cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.88642 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CX-01A-12R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8217_KD_U2AF2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.30897 mammalian phenotype MPO Gene-Phenotype Associations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8IF-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MRK-NU-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A623-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Bone marrow TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.1 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193900,GSE193905_1_v_0_pura_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null C2BBE1 CCLE Cell Line Gene CNV Profiles 1.0 1.49814 GSE182680,GSE182683_10_v_4_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PVOW-2626-SM-32PL8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.959622 MOLT-16 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.31577 RAD21_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.48718 CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null core of T-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.33975 Germinal vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.951 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.18682 BC-20-WA90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.202148 impaired fertilization MGI Mouse Phenotype Associations 2023 1.0 null GTEX-P44H-2426-SM-2XCEJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08776 WB-17-DI74_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.239624 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal sex gland morphology MPO Gene-Phenotype Associations 1.0 null ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_7366_KD_EglN2_SRP325972 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 15.8987 GTEX-XOTO-2926-SM-4B65G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.853317 SLC16A11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.1306 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Colorectal Carcinoma DisGeNET Gene-Disease Associations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A46E-01A-31R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SJXC-1226-SM-4DM78 GTEx Tissue Sample Gene Expression Profiles 1.0 0.958678 GSE201309_1_v_2_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-RNOR-0926-SM-2TF56 GTEx Tissue Sample Gene Expression Profiles 1.0 1.70862 GSE152441,GSE152442_0_v_5_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null cerebellar cortex_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.88642 NAE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09464 Perturb_7852_KD_XAB2_SRP193107 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 12.4304 GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40326 GTEX-VJWN-0426-SM-3GIJI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27077 cell part LOCATE Predicted Protein Localization Annotations 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-63-A5MY-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Inflammation CTD Gene-Disease Associations 1.0 1.48042 GSE169152_3_v_7_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null 19306436-TableS2a GeneSigDB Published Gene Signatures 1.0 null MDA-MB-435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.39532 muscle GTEx Tissue Gene Expression Profiles -1.0 -2.08487 GSE137653_4_v_0_siglecf_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11714 decreased oocyte number MPO Gene-Phenotype Associations 1.0 null MRPS31 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21682 GTPBP4 Pathway Commons Protein-Protein Interactions 1.0 null Ribonucleoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.969 MAF::NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.9624 GOLGA3 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-L9-A443-01A-12R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null eGFP-HDAC8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H727 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 SYNGAP1 Pathway Commons Protein-Protein Interactions 1.0 null GSE195559_2_v_7_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.841105 OCI-AML3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.20479 HuCCT1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.52769 medial parabrachial nucleus,right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13881 GSE182680,GSE182683_10_v_3_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100316_TCx_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.00566 FF-28-ES17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.428335 GSE171175,GSE171181_1_v_2_e7107_human RummaGEO Drug Perturbation Signatures -1.0 null cellular_component GO Cellular Component Annotations 2015 1.0 null RNA recognition motif domain InterPro Predicted Protein Domain Annotations 1.0 null GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49446 GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles -1.0 -2.09167 H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RPL23A Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.49012 periventricular stratum of p3ZL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07418 KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WOFM-1326-SM-3MJFR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59157 Planktonic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.671 Cytosolic small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.548 SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.32265 vesicle GO Cellular Component Annotations 2015 1.0 null GTEX-UPIC-1126-SM-4IHLO GTEx Tissue Sample Gene Expression Profiles 1.0 1.13527 SPI1 ENCODE Transcription Factor Targets 1.0 null Integument TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.077 NCI-H727 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06849 Ectorhinal area/Layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18986 Perturb_14737_OE_ADAR1_SRP250165 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.46785 germinal GeneRIF Biological Term Annotations 1.0 null GSE158834_10_v_13_palm_human RummaGEO Gene Perturbation Signatures 1.0 null SPATA5L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20064 CAL29 CCLE Cell Line Gene CNV Profiles 1.0 1.74641 Upper epidermis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.242 GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12607 lymphnode_4b HPA Tissue Sample Gene Expression Profiles 1.0 1.48353 RPL17 Pathway Commons Protein-Protein Interactions 1.0 null GSE191110_0_v_1_dnajc12_human RummaGEO Gene Perturbation Signatures 1.0 null AC-35-CK01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.571233 Autosomal dominant disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.105 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null thyroid_5b HPA Tissue Sample Gene Expression Profiles 1.0 1.66935 17880687-TableS3 GeneSigDB Published Gene Signatures 1.0 null PBX3 ENCODE Transcription Factor Targets 1.0 null EDC4 Pathway Commons Protein-Protein Interactions 1.0 null TCF3 ENCODE Transcription Factor Targets 1.0 null GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -2.18992 GPHA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08023 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MED1 Pathway Commons Protein-Protein Interactions 1.0 null NCIH1568 DepMap CRISPR Gene Dependency 1.0 2.30913 GSE231799_3_v_5_nfkbie_mouse RummaGEO Gene Perturbation Signatures -1.0 null Translation repressor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.897 H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VZ in posterosuperior (dorsal) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.825734 AC-30-XU83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.974433 CA-75-HA22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.382394 H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JIMT1 CCLE Cell Line Gene CNV Profiles 1.0 1.76186 SK-MEL-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31988 CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_13402_KD_PBX1_SRP302267 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.89276 WSU-NHL COSMIC Cell Line Gene Mutation Profiles 1.0 null LXF289 CCLE Cell Line Gene CNV Profiles -1.0 -1.36853 TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.473469 H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CEBPB_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X638-0326-SM-47JY1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.858295 Skeletal Muscle Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 2.49554 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.43673 Acute Myeloid Leukemia_LAML_TCGA-AB-2930-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ccnd1_18413728_imr_neuroblastoma_lof_human_gpl570_gse8866 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.074189 SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.557346 SRF_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AB-33-EM56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.61786 H3K36me3_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SH-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4638-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormal meiosis MPO Gene-Phenotype Associations 1.0 null Azoospermia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.309 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36285 H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Phenytoin (sodium)_A-427 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.017785 GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.989121 NTERA-2_CL_D1 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Uterus GTEx Tissue Gene Expression Profiles 2023 1.0 1.34452 SW1116 CCLE Cell Line Gene Expression Profiles 1.0 1.35129 GSE140322_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-R55C-0326-SM-3GAF1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00744 H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CEBPB_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF2 ENCODE Transcription Factor Targets 1.0 null PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2 Rummagene Transcription Factor Associations 2026 1.0 null Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.297 H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AI-1526-SM-3GIJ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59679 intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GM-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZMIZ1 ENCODE Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2988-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE207122_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13212 FIP1L1 Pathway Commons Protein-Protein Interactions 1.0 null piP-body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.603 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ICC2 DepMap CRISPR Gene Dependency 1.0 2.99114 GTEX-S341-1826-SM-3K2AB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10588 GSE245778_1_v_0_runx1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38224 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4815-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-N7MS-2625-SM-3LK77 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22395 HNF4 MotifMap Predicted Transcription Factor Targets 1.0 null GSE152441,GSE152442_6_v_4_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.33332 GTEX-QDVJ-1926-SM-2S1PJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.264 Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.127 Colon carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.01 metabolic process GO Biological Process Annotations 2015 1.0 null raphe magnus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18093 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPIC-0226-SM-3GADO GTEx Tissue Sample Gene Expression Profiles 1.0 0.88064 NCI-H1734 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05312 GSE89057_0_v_1_sox5_human RummaGEO Gene Perturbation Signatures -1.0 null Interpeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22364 PRPH Pathway Commons Protein-Protein Interactions 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PELP1 Pathway Commons Protein-Protein Interactions 1.0 null intestine TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.24676 GSE74490_0_v_1_triptolide_mouse RummaGEO Drug Perturbation Signatures 1.0 null Stomach disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.036 GTEX-WFON-1626-SM-4LVMV GTEx Tissue Sample Gene Expression Profiles 1.0 0.963492 FAM120A Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-A4SU-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSS CCLE Cell Line Gene Expression Profiles 1.0 1.49977 Endocarditis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.268 Ileocecum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.204 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null orbital frontal cortex_4 mos_M_12890 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.61831 GTEX-XGQ4-0426-SM-4AT4I GTEx Tissue Sample Gene Expression Profiles 1.0 1.06034 cuneiform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.7328 Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.05009 PMC12634441-41375_2025_2771_MOESM7_ESM.xlsx-RNAseq-Table_S2_Bulk_RNA-seq_GATA2_vs_control_Only_p-adj_0_05_GATA2 Rummagene Transcription Factor Associations 2026 1.0 null DDX50 Pathway Commons Protein-Protein Interactions 1.0 null central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.11047 Lung adenocarcinoma_LUAD_TCGA-MP-A5C7-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Culmen Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05752 Rectum cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.174 abnormal cell physiology MGI Mouse Phenotype Associations 2023 1.0 null GTEX-RTLS-1326-SM-46MUN GTEx Tissue Sample Gene Expression Profiles 1.0 0.95359 dm15 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.139 H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YW-0326-SM-2I5EI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09017 Adrenocortical carcinoma_ACC_TCGA-OR-A5KX-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nucleotide-binding alpha-beta plait domain InterPro Predicted Protein Domain Annotations 1.0 null DA-28-TM43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.261373 S1P_Deficiency_GDS3654_521_mouse_Liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-OHPL-1626-SM-2HMIR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36396 PMC11903305-41586_2024_8507_MOESM3_ESM.xlsx-Table_S1_MAF-Hugo_Symbol_MAF Rummagene Transcription Factor Associations 2026 1.0 null CA-23-BW20_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.458423 female infertility IMPC Knockout Mouse Phenotypes 1.0 null inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.41699 EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRDX3 Pathway Commons Protein-Protein Interactions 1.0 null Cytoplasmic ribonucleoprotein granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.902 GSE195559_6_v_9_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of r1BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15357 Transcription preinitiation complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.415 Lingula (I), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.96678 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null RKN CCLE Cell Line Gene CNV Profiles 1.0 1.56666 UACC812 CCLE Cell Line Gene Expression Profiles 1.0 1.6438 GSE120612_7_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BCLAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAL1::TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.5 Anterodorsal preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.63631 decreased oocyte number MGI Mouse Phenotype Associations 2023 1.0 null MA-88-CA03_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215987 abnormal fertility/fecundity MPO Gene-Phenotype Associations 1.0 null GSE226285_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null TOV-112D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.974796 parabigeminal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79323 19429869-TableS1 GeneSigDB Published Gene Signatures 1.0 null SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.27131 GSE201309_5_v_0_matrine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE103068_5_v_8_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10768 GTEX-WHPG-2226-SM-3NMBO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55563 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80V-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles 1.0 1.19274 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.00164 abnormal female genitalia morphology MPO Gene-Phenotype Associations 1.0 null hippocampus (hippocampal formation)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29331 HCC366 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.901532 GTEX-WVLH-0626-SM-3MJG7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.67499 SRF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null basal ventral medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23895 EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.382065 hippocampus (hippocampal formation)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.31999 GTEX-XV7Q-0426-SM-4BRVN GTEx Tissue Sample Gene Expression Profiles 1.0 0.836224 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A5A3-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-N7MS-0426-SM-2YUN6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16653 GTEX-WHSE-0011-R3A-SM-3P5ZM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.847719 chr20_44899880_G_A_b38 GTEx eQTL 2025 1.0 2.94707 GSE149123,GSE149128_3_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null mantle zone of r2Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1491 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.881435 Posterior hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27098 cerebellar cortex_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21182 GSE168473_0_v_1_isoniazid_human RummaGEO Drug Perturbation Signatures 1.0 null PMC12673788-12967_2025_7484_MOESM5_ESM.xlsx-Venne_panel-Only_OCT4_related_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null GSE195559_0_v_9_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null abnormal female reproductive gland morphology MPO Gene-Phenotype Associations 1.0 null FOXA1_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNT-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.83244 Ectorhinal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20631 Neurodegenerative disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.207 GTEX-T6MN-0726-SM-32PML GTEx Tissue Sample Gene Expression Profiles 1.0 1.02286 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE255432_4_v_3_imeglimin_mouse RummaGEO Drug Perturbation Signatures -1.0 null SNU-449 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.19486 Rectus femoris TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.667 KM12 CCLE Cell Line Gene Expression Profiles 1.0 1.96505 CAF-1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.87 Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.742 RPL3L Pathway Commons Protein-Protein Interactions 1.0 null SR-786 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.00597 RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.54446 MYB-21317192-ERMYB-MOUSE ChEA Transcription Factor Targets 2022 1.0 null heart_6b HPA Tissue Sample Gene Expression Profiles -1.0 -1.39556 H3K4me3_Fetal Brain Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null extracellular vesicle GO Cellular Component Annotations 2015 1.0 null GSE143782_3_v_4_calcitriol_human RummaGEO Drug Perturbation Signatures 1.0 null BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.31294 Temporal association areas, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19077 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FD-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89852 Sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.402 Depressive disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.742 mammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4516 nucleus LOCATE Predicted Protein Localization Annotations 1.0 null PMC12126244-jci-135-184115-s239.xlsx-Table_3_Suppl_Fig_16-Genes_down-regulated_in_SOX9_low_tumors_744_genes_SOX9 Rummagene Transcription Factor Associations 2026 1.0 null icSARS CoV_12Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.21971 superficial stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0611 KINGS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Colonic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.207 TC-95-IR96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.273708 primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07858 KA-81-AG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.554711 LE-40-JW92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.250678 GTEX-REY6-0526-SM-2TF5M GTEx Tissue Sample Gene Expression Profiles 1.0 1.12555 Accessory olfactory bulb, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21456 PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-O5YT-1026-SM-3MJGF GTEx Tissue Sample Gene Expression Profiles 1.0 0.997887 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_x_CENPX Rummagene Transcription Factor Associations 2026 1.0 null Zona pellucida TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.271 POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.914561 GSE175787_13_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-U3ZG-0326-SM-47JXN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.891915 CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.7401 Tcf12 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.5421 heart muscle HPA Tissue Gene Expression Profiles -1.0 -1.16375 GTEX-SN8G-1526-SM-4DM79 GTEx Tissue Sample Gene Expression Profiles 1.0 1.70624 GSE165548_2_v_8_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-T2YK-2226-SM-32QPT GTEx Tissue Sample Gene Expression Profiles 1.0 1.23922 GTEX-XOTO-2826-SM-4B65I GTEx Tissue Sample Gene Expression Profiles 1.0 0.948897 GSE180200,GSE180201_2_v_9_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OXRO-0011-R10A-SM-2I5EH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965355 ESR2 Pathway Commons Protein-Protein Interactions 1.0 null GSE202434,GSE202438_13_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null FAM47E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14542 23132/87 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.841105 CHD1 ENCODE Transcription Factor Targets 1.0 null Right_Atrium Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.27048 H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RKN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14682 NCI-H1882 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09271 H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null amygdaloid complex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29331 single-organism process GO Biological Process Annotations 2015 1.0 null CTCF_GM12872_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PY-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of lung_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_257_KD_KLF6_SRP150445 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.37941 MAFG::NFE2L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2014 GTEX-OIZI-0626-SM-2XCEH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.86322 GSE199606_5_v_4_ricin_mouse RummaGEO Drug Perturbation Signatures -1.0 null SRSF5 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_13401_KD_PBX1_SRP302267 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GTEX-WFJO-0926-SM-4LVM2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.894666 FD-91-OK66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.62728 TGFBI CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10566 cellular metabolic process GO Biological Process Annotations 2015 1.0 null TENT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0565 TYK-NU Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.91037 RALY Pathway Commons Protein-Protein Interactions 1.0 null icSARS CoV_7Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 3.00766 GSE171837_3_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_K562_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null Urinary system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.21 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Supplementary_Table_2E_Contrast_ATF4-def_Tg_8h_vs_HCT116_Tg_8h_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null Temporal association areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50514 Prostate adenocarcinoma_PRAD_TCGA-2A-A8VT-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DACT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22445 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null esophagus HPA Tissue Gene Expression Profiles -1.0 -0.846182 Vagina GTEx Tissue Gene Expression Profiles 2023 1.0 1.60626 White blood cell count (basophil) GWAS Catalog SNP-Phenotype Associations 2025 1.0 0.81549 CTCF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB7A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleus sagulum, deep part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12766 PK-45H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16074 GSE149264,GSE149267_2_v_5_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE152441,GSE152442_0_v_2_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null D423MG DepMap CRISPR Gene Dependency 1.0 3.99685 FAM179B Pathway Commons Protein-Protein Interactions 1.0 null intermediate stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12674 Ventromedial hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28834 MED12 Pathway Commons Protein-Protein Interactions 1.0 null Blastodisc TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.504 BRD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.75862 POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null perimammillary part of PHyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21588 VZ in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44995 GSE200839,GSE233826_3_v_4_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null BF-97-LS55_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.19951 H3K4me3_CD3 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null brain_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.12287 paraventricular nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31059 GSE171177,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures -1.0 null WM983B CCLE Cell Line Gene CNV Profiles 1.0 1.35343 Elagolix sodium_SW1417 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00921163 organic substance metabolic process GO Biological Process Annotations 2015 1.0 null POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193402_0_v_2_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K79me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HA-22-CY42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.34086 GTEx Heart 20-29 vs 60-69 GTEx Tissue-Specific Aging Signatures 1.0 6.71824 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A5A6-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cortico-medial group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.953996 GTEX-OIZF-1526-SM-3MJGY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08669 AA-94-TU18_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.569497 biological_process GO Biological Process Annotations 2015 1.0 null Neoplasms, Experimental CTD Gene-Disease Associations 1.0 1.13997 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CUX1 ENCODE Transcription Factor Targets 1.0 null lymph node HPA Tissue Gene Expression Profiles 1.0 1.10983 MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null P300-27058665-CHIP-SEQ-ZR-75-30CELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null JD-81-YX02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.06255 SG in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.850882 ZNF384_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AG-0826-SM-2HMKF GTEx Tissue Sample Gene Expression Profiles 1.0 1.62595 GSE188458_2_v_4_hydrogen peroxide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WHSE-1126-SM-3NMBU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.913148 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.897656 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE95386_0_v_1_trim24_human RummaGEO Gene Perturbation Signatures 1.0 null RXRA::VDR JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.6 predominant GeneRIF Biological Term Annotations 1.0 null VZ in subgenual cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.51651 GTEX-R55F-1726-SM-2TF4R GTEx Tissue Sample Gene Expression Profiles 1.0 1.07134 H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE120612_7_v_0_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SR786 CCLE Cell Line Gene CNV Profiles -1.0 -1.89755 ESRRB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 21.5408 OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.07797 anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.27467 ERR2 (ESRRB) MotifMap Predicted Transcription Factor Targets 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Mammary Neoplasms, Animal CTD Gene-Disease Associations 1.0 1.03678 CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE131649_6_v_5_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null MCF7_ZM 447439_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0118148 m2 part of paranigral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00037 GTEX-WWYW-0011-R11A-SM-3NB38 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.846525 EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38203 Mature ovarian follicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.478 ZNF530 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 75.4389 GTEX-V1D1-1926-SM-4JBGX GTEx Tissue Sample Gene Expression Profiles 1.0 1.16132 intermediate stratum of r2Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15539 GSE238116_3_v_0_egr1_human RummaGEO Gene Perturbation Signatures 1.0 null MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r1Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34782 RRP15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.72231 YD-49-HM53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.679532 Perturb_11920_OE_IRF3_SRP114539 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 Pellicular membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.87 GSE149264,GSE149267_9_v_3_trp53_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PSDG-1526-SM-48TCY GTEx Tissue Sample Gene Expression Profiles 1.0 1.05307 Tailbud stage TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.692 GNL3 Pathway Commons Protein-Protein Interactions 1.0 null CCDC106 Pathway Commons Protein-Protein Interactions 1.0 null MCF7_Filgotinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0132561 JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_BE2C_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.7602 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A2LS-01A-22R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MED17 Pathway Commons Protein-Protein Interactions 1.0 null Pharyngeal muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.247 GSE102467_3_v_0_pazopanib_human RummaGEO Drug Perturbation Signatures 1.0 null EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.10151 CEM-VBL100 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.758 GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893932 POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135030_3_v_0_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null III, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.903222 MYOD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4792 RPS7 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_6671_KO_KLB_SRP386785 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Perturb_6863_KO_CDK8_SRP299261 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 anterior group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06312 abnormal ovarian follicle morphology MPO Gene-Phenotype Associations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5092-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1568 COSMIC Cell Line Gene Mutation Profiles 1.0 null HDAC2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-A4DG-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-RM2N-0526-SM-2TF4N GTEx Tissue Sample Gene Expression Profiles 1.0 0.9953 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RTLS-0526-SM-2TF64 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25861 IZ in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.948088 HDAC2_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-Vietnam-1203-2004(H5N1)_3Hour_21865398_GSE28166 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.26393 CTCF_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CF-87-AS90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.86833 EGR1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE211128_7_v_6_angptl4_human RummaGEO Gene Perturbation Signatures 1.0 null Nerve Degeneration CTD Gene-Disease Associations 1.0 1.04465 GTEX-WVLH-3126-SM-3MJGA GTEx Tissue Sample Gene Expression Profiles 1.0 1.11295 SIG-M5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.39857 AC-47-YZ27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.577968 SA-32-CC58_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.34586 CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.50086 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IE-01A-21R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-A456-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRSF2 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RVPV-1226-SM-2TF73 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30506 GSE142684_2_v_7_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null cellular macromolecule metabolic process GO Biological Process Annotations 2015 1.0 null GSE199606_5_v_4_csf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HTRA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09723 H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null thyroid gland HPA Tissue Gene Expression Profiles 1.0 1.71305 ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-4587-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r2 part of vestibular sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1509 CTCF_A549_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XYKS-2426-SM-4AT43 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92805 GSE126463_6_v_2_arid2_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15937 NCBP1 Pathway Commons Protein-Protein Interactions 1.0 null ZE-45-CG69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237689 mRNA surveillance pathway KEGG Pathways 2026 1.0 null GSE210662_3_v_1_znf165_human RummaGEO Gene Perturbation Signatures -1.0 null GSE112761,GSE112767_1_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.199 Mood disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.742 CA-68-KG29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.80421 CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CBX3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV_48Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.23799 heterocyclic compound binding GO Molecular Function Annotations 2015 1.0 null PMC12069319-Table1.xlsx-OCAB_p35_BirA-Gene_Symbol_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Eye cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.516 SNU-C1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30587 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OOBJ-2626-SM-2I3F6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.96447 HDAC2 ENCODE Transcription Factor Targets 1.0 null D-542MG Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.10207 SP140L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09367 Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.051 CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ANAPC5 Pathway Commons Protein-Protein Interactions 1.0 null NCIH889 CCLE Cell Line Gene CNV Profiles -1.0 -1.49266 GTEX-OHPM-2626-SM-33HC5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20712 GABP-19822575-HepG2-human ChEA Transcription Factor Binding Site Profiles 1.0 null Brain - Amygdala GTEx Tissue Gene Expression Profiles 2023 1.0 1.67267 Chronotype GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.43979 SK23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.879612 GTEX-R53T-1826-SM-3GIJX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77053 GTEX-WL46-0626-SM-3LK7R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89057 GSE191037_0_v_1_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null BBS10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08262 GTEX-REY6-1226-SM-48FDR GTEx Tissue Sample Gene Expression Profiles 1.0 1.13888 ZNF830 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07425 Colon cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.194 HAND2-30127528-KELLY-HUMAN-BRAIN-NEUROBLASTOMA ChEA Transcription Factor Targets 2022 1.0 null C5orf22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04405 H3K4me3_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AP2A1 Pathway Commons Protein-Protein Interactions 1.0 null GSE189609_1_v_0_hax1_human RummaGEO Gene Perturbation Signatures 1.0 null BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null infertility MPO Gene-Phenotype Associations 1.0 null Sarcoma_SARC_TCGA-X6-A7WD-01A-21R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QMR6-1326-SM-32PLB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930327 GSE245270_1_v_0_isoproterenol_human RummaGEO Drug Perturbation Signatures 1.0 null ACTR3 Pathway Commons Protein-Protein Interactions 1.0 null PRRC2C Pathway Commons Protein-Protein Interactions 1.0 null Perturb_12381_OE_KIF17_SRP340935 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.17722 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE222758_0_v_1_clofazimine_human RummaGEO Drug Perturbation Signatures 1.0 null HS 940.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.832374 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-62-A470-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.203 nucleoside phosphate binding GO Molecular Function Annotations 2015 1.0 null RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.932151 Lung adenocarcinoma_LUAD_TCGA-97-8171-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_6725_KD_HOXB8_SRP165671 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.82202 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null SIN3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08884 BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.30751 GSE240258_0_v_1_prmt1_human RummaGEO Gene Perturbation Signatures -1.0 null posterior group of nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.969118 SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null colonrectum_f HPA Tissue Sample Gene Expression Profiles -1.0 -0.857315 RPL36 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-UTHO-0726-SM-3GAEN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.94509 GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92737 Germ cell nucleus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.918 GSPT1 Pathway Commons Protein-Protein Interactions 1.0 null abnormal gametogenesis MPO Gene-Phenotype Associations 1.0 null RPL32 Pathway Commons Protein-Protein Interactions 1.0 null parolfactory gyri, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.831391 COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.898524 RBM47 Pathway Commons Protein-Protein Interactions 1.0 null IE-80-DC24_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.21343 H3K27ac_CD4 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-V1D1-2426-SM-3GAER GTEx Tissue Sample Gene Expression Profiles -1.0 -0.921817 Cytoplasmic side of Golgi membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.993 CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.92088 Liver hepatocellular carcinoma_LIHC_TCGA-ED-A97K-01A-21R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NB-80-IM48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.737934 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4912-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE203329_0_v_1_mettl5_human RummaGEO Gene Perturbation Signatures -1.0 null lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.91802 MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF7L2 ENCODE Transcription Factor Targets 1.0 null MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03624 MCF7_Navitoclax_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0179187 YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RBMXL2 Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4341-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE129811_5_v_0_niacin_human RummaGEO Drug Perturbation Signatures 1.0 null S0-EE-Y7IR_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.219956 Myotonic cataract DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.706 Mitochondrial cloud COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.942 RAD21_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null MRPS9 Pathway Commons Protein-Protein Interactions 1.0 null FD-20-OG99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.459487 MRPS5 Pathway Commons Protein-Protein Interactions 1.0 null Inner mucus layer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.752 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.26706 Neuron projection cytoplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.659 Adipose - Subcutaneous GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.739111 GSE182680,GSE182683_5_v_1_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Ooplasm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.64 LOVO COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC11098130-pnas.2322688121.sd01.xlsx-NER_Contact_vs_mono-id_NR1H2 Rummagene Transcription Factor Associations 2026 1.0 null intermediate stratum of r1Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09921 CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UACC893 DepMap CRISPR Gene Dependency 1.0 5.40917 GSE202434,GSE202438_3_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2023 1.0 null inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.3776 MDA-MB-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.60916 dorsomedial nucleus, terminal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45641 mediodorsal nucleus of thalamus_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.49988 NCIH69 CCLE Cell Line Gene CNV Profiles -1.0 -1.66518 YA-85-VH07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237298 GSE158834_2_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null abnormality of metabolism/homeostasis GWASdb SNP-Phenotype Associations 1.0 0.05103 Parabrachial nucleus, medial division, external medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27413 GTEX-PX3G-1626-SM-2S1PT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34045 ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.54023 area postrema Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.977021 GTEX-U3ZM-1226-SM-3DB9G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38764 GTEX-RUSQ-0226-SM-47JWT GTEx Tissue Sample Gene Expression Profiles 1.0 0.954536 Peritonitis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.383 H3K9ac_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCIH322 CCLE Cell Line Gene Expression Profiles -1.0 -1.46003 CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE215155_0_v_1_golph3_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_GM19193_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24311 Melancholic depression DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.742 CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MPF complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.236 appendices_4a HPA Tissue Sample Gene Expression Profiles 1.0 0.824033 viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055714 WC-59-RG09_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.305018 Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61I-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE164874_5_v_12_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null PK59 CCLE Cell Line Gene CNV Profiles 1.0 2.30201 GSE121866_0_v_3_six4_human RummaGEO Gene Perturbation Signatures -1.0 null HS683 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-R55F-1526-SM-2TF4X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14171 CTCF_fibroblast of pedal digit skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5001-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_16934_KD_GLI1_SRP286421 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.8133 GD-46-OD81_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222271 Perturb_302_KD_HHEX_SRP405197 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.38028 Perturb_12915_OE_FUT8_SRP342334 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 RPL36AL Pathway Commons Protein-Protein Interactions 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8430-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null poly-purine tract binding GO Molecular Function Annotations 2025 1.0 null NCI-H630 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me1_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null AF-83-BX08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.266045 ARID3A ENCODE Transcription Factor Targets 1.0 null COPG2 Pathway Commons Protein-Protein Interactions 1.0 null GSE222047_0_v_1_imidazole_human RummaGEO Drug Perturbation Signatures 1.0 null U1 snRNP COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.825 ATF3-27146783-CHIP-SEQ-COLON-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MKN7 CCLE Cell Line Gene CNV Profiles 1.0 1.53958 GTEX-UTHO-3126-SM-3P5ZB GTEx Tissue Sample Gene Expression Profiles 1.0 0.91268 PMC12830621-41467_2025_67611_MOESM11_ESM.xlsx-Sheet1-Suppl_Data-9_Common_differentially_up-regulated_genes_in_high_vs_low_Mecom_MECOM_mouse_KME_AML_cells_and_human_AML_from_4_public_databases_MECOM Rummagene Transcription Factor Associations 2026 1.0 null membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 IGROV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null TMEM81 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26315 POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null chr20_44898696_C_T_b38 GTEx eQTL 2025 1.0 1.30464 VZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.894851 CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mrsv TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.482 Cell surface furrow COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.774 SGS cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.217 GSE191015_0_v_2_gsdmb_human RummaGEO Gene Perturbation Signatures -1.0 null lateral subdivision of area 9 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12393 sirolimus_homo sapiens_gpl2895_gse16944 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SK-OV-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-X4XX-0926-SM-46MV7 GTEx Tissue Sample Gene Expression Profiles 1.0 2.70702 GTEX-XPVG-2526-SM-4B66D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41625 inner SZ in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.859621 intermediate stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.125 EGR1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.449888 SNU-216 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.944025 Econazole_A-427 Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.00851075 GTEX-NFK9-0726-SM-2HMJW GTEx Tissue Sample Gene Expression Profiles 1.0 1.69065 POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null liver GeneRIF Biological Term Annotations 1.0 null AB-82-EP26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.23579 amygdaloid complex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.17225 MYC ENCODE Transcription Factor Targets 1.0 null BL5899 (NIN) NURSA Protein Complexes 1.0 null HTATSF1 Pathway Commons Protein-Protein Interactions 1.0 null MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZFP69 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.24285 CTCF_astrocyte of the spinal cord_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NUR77 MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-RWSA-0826-SM-2XCBF GTEx Tissue Sample Gene Expression Profiles 1.0 1.92321 GTEX-P44H-0011-R4A-SM-2XCEW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.82917 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null abnormal germ cell morphology MPO Gene-Phenotype Associations 1.0 null PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 678 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.93622 ELMSAN1 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48231 GSE110268_0_v_3_foxd1_human RummaGEO Gene Perturbation Signatures 1.0 null PMC6056651__F7 PFOCR Pathway Figure Associations 2024 1.0 null SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null oocyte maturation GO Biological Process Annotations 2015 1.0 null cumulus-oocyte complex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.304 SLC16A7+ cell_Lung_Human CellMarker Gene-Cell Type Associations 1.0 null GTEX-P78B-1326-SM-3P611 GTEx Tissue Sample Gene Expression Profiles 1.0 0.960137 H4K8ac_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null pontine nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.36516 YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null reproductive system phenotype MPO Gene-Phenotype Associations 1.0 null MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-66-2793-01A-01R-1201-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Granulosa cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.444 mantle zone of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03887 EZH2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE206270_1_v_0_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null Distal myopathy with rimmed vacuoles DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.331 GSE120612_6_v_5_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null r1 part of vestibular nucleus Y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35058 GSE242290_1_v_2_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null SW982 DepMap CRISPR Gene Dependency 1.0 2.14403 GTEX-SNMC-0826-SM-4DM66 GTEx Tissue Sample Gene Expression Profiles 1.0 0.95059 SP4 ENCODE Transcription Factor Targets 1.0 null SRF_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.7009 SF126 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.88446 Aedesalbopictus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.588 NCI-H2342 COSMIC Cell Line Gene Mutation Profiles 1.0 null NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null CMK115 CCLE Cell Line Gene Expression Profiles -1.0 -1.71967 CTCF_HCT116_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8851354-Table_5.xlsx-Ruxolitinib_reg_FD-bound-Supplementary_Table_5_Genes_regulated_by_ruxolitinib_that_are_FUS-DDIT3_targets_in_MLS_402-91_cells_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null BL695 (CC2D1A) NURSA Protein Complexes 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YI-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null K562_Cerdulatinib_100nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0168875 Perturb_12371_KO_NR4A1_SRP293165 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -11.189 Male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.32 PMC12069319-Table1.xlsx-OCAB_p34_BirA-Gene_Symbol_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null inherited metabolic disorder GWASdb SNP-Disease Associations 1.0 0.190476 orbital frontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.954664 MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17169 r1 part of ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10805 ventral tuberomammillary nucleus, intermediate part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.01912 19139136-TableS3 GeneSigDB Published Gene Signatures 1.0 null striatum_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09213 CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UTHO-2726-SM-4JBH9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.7875 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12875_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hela HPA Cell Line Gene Expression Profiles 1.0 0.890225 Lung adenocarcinoma_LUAD_TCGA-55-A492-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.246036 POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-1326-SM-2TF6T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66892 SMARCC2 Pathway Commons Protein-Protein Interactions 1.0 null GSE158431_5_v_1_pioglitazone_mouse RummaGEO Drug Perturbation Signatures 1.0 null MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42061 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null decreased cumulus expansion MGI Mouse Phenotype Associations 2023 1.0 null Perturb_14644_KO_PC_SRP388542 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.97116 GSE227698_2_v_1_g0s2_human RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null C19orf53 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21206 UBC Pathway Commons Protein-Protein Interactions 1.0 null substantia nigra, pars compacta, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.01022 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HT-1376 COSMIC Cell Line Gene Mutation Profiles 1.0 null IRF1 ENCODE Transcription Factor Targets 1.0 null intermediate stratum of CbH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33938 XE-29-LT20_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.25703 CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NF-21-HQ00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220525 anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1761 K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.36815 CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE147056_4_v_1_actl6b_mouse RummaGEO Gene Perturbation Signatures -1.0 null retrohypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31291 KDM5A ENCODE Transcription Factor Targets 1.0 null GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15056 MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.955762 Kidney renal papillary cell carcinoma_KIRP_TCGA-AT-A5NU-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-Q2AI-0326-SM-2I3EK GTEx Tissue Sample Gene Expression Profiles 1.0 0.954964 GTEX-WHWD-0426-SM-3LK83 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03128 GSE247764_3_v_2_nell2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-WP-A9GB-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ventromedial hypothalamic nucleus, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15119 Sporocyst TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.864 KU812 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09208 REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE201309_1_v_6_matrine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QEL4-2126-SM-447AE GTEx Tissue Sample Gene Expression Profiles 1.0 0.922968 SIRT6 ENCODE Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2921-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE143955_1_v_0_ripk1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE121198,GSE129779_0_v_1_arid1a_human RummaGEO Gene Perturbation Signatures 1.0 null GTF3C5 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null FE-82-WB22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.409907 PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null Septum pellucidum TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.989 alimentary canal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063905 CHD7_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30587 EC-89-AJ93_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.289349 PMC7441006-41388_2020_1389_MOESM2_ESM.xlsx-Supplementary_Table_1-Prostate-Specific_MYC_Overexpression_MYC Rummagene Transcription Factor Associations 2026 1.0 null MOLP-8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Perturb_6866_KO_CDK8/CDK19_SRP299261 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CTCF ENCODE Transcription Factor Targets 1.0 null MYC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.3671 Lobules IV-V, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07923 GSE161825_1_v_0_tipranavir_human RummaGEO Drug Perturbation Signatures 1.0 null MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.919942 SCP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18139 SNRPD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08711 GTEX-U4B1-1426-SM-4DXTX GTEx Tissue Sample Gene Expression Profiles 1.0 1.48246 CTCFL_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WY7C-0226-SM-3NB37 GTEx Tissue Sample Gene Expression Profiles 1.0 0.987737 MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRO-0011-R2A-SM-3NB1W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.849993 Cognitive disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.742 H3K27me3_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.39647 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE128730_0_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null Exoneme COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.59 GTEX-T6MN-0626-SM-32PM9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.53798 extracellular organelle GO Cellular Component Annotations 2015 1.0 null GTEX-S7SE-0926-SM-2XCD6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.845331 Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.203 GSE240468_3_v_2_nfyc_human RummaGEO Gene Perturbation Signatures 1.0 null Anterior amygdalar area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14729 mediodorsal nucleus of thalamus_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.9707 K562_AZD1480_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0165043 nucleus of the lateral olfactory tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.12257 Cognition Disorders CTD Gene-Disease Associations 1.0 1.1122 POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HS-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null exon-exon junction complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.483 GTEX-WH7G-0526-SM-3NMBI GTEx Tissue Sample Gene Expression Profiles 1.0 0.900784 primary metabolic process GO Biological Process Annotations 2015 1.0 null MYO3B Pathway Commons Protein-Protein Interactions 1.0 null Perturb_7550_OE_SEHBP_SRP300266 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.73947 GTF3C4 Pathway Commons Protein-Protein Interactions 1.0 null GSE152441,GSE152442_6_v_3_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null EA-62-MI89_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.333456 HOP-62 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.65974 KA-29-AB08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.327158 COLO 206F Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.894113 RAD21_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ventromedial hypothalamic nucleus, dorsomedial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58698 ZEB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.4997 KMH2 CCLE Cell Line Gene CNV Profiles -1.0 -1.32723 arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.58554 abnormal female reproductive system physiology MPO Gene-Phenotype Associations 1.0 null GSE67266_2_v_4_etoposide_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QXCU-0326-SM-2TC63 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07033 all GWASdb SNP-Phenotype Associations 1.0 0.031781 MRPL44 Pathway Commons Protein-Protein Interactions 1.0 null TT CCLE Cell Line Gene CNV Profiles -1.0 -1.58843 decreased ovulation rate MGI Mouse Phenotype Associations 2023 1.0 null rh30 HPA Cell Line Gene Expression Profiles -1.0 -1.24478 GSE158834_10_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE169356_0_v_5_ivermectin_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_LNCaP clone FGC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleobase-containing compound metabolic process GO Biological Process Annotations 2015 1.0 null Paraventricular hypothalamic nucleus, parvicellular division, anterior parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53989 CTCF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AC-76-JB92_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220029 septal nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.935264 ASPC1 DepMap CRISPR Gene Dependency 1.0 2.40224 GTEX-O5YT-0526-SM-32PK8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.930815 GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09432 Cochlear nucleus, subpedunclular granular region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6583 hsa-miR-335-5p MiRTarBase microRNA Targets 1.0 null RBPJ JASPAR Predicted Human Transcription Factor Targets 2025 1.0 14.7889 Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.09208 GSE165636_0_v_4_tofacitinib_human RummaGEO Drug Perturbation Signatures -1.0 null Extraocular muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.906 SMAD1-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null GSE180200,GSE180201_5_v_0_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null Dorsal premammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18126 GTEX-QV44-0826-SM-2S1RG GTEx Tissue Sample Gene Expression Profiles 1.0 1.98016 HC-92-HE59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.553424 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE182680,GSE182683_5_v_11_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4817-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K79me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleic acid metabolic process GO Biological Process Annotations 2015 1.0 null HDAC6 ENCODE Transcription Factor Targets 1.0 null H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPL13AP3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-XGQ4-0226-SM-4GIDS GTEx Tissue Sample Gene Expression Profiles 1.0 0.825825 GSE211286_4_v_6_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null HP1BP3 Pathway Commons Protein-Protein Interactions 1.0 null Ferroxidase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.522 CTCF_medulloblastoma_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.922799 BA-84-WN26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.675922 HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03624 PECAPJ41CLONED2 DepMap CRISPR Gene Dependency 1.0 2.91663 abnormal female meiosis MPO Gene-Phenotype Associations 1.0 null GSE114992,GSE114993_7_v_11_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE164874_5_v_3_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null GTEX-T5JW-1226-SM-3GACY GTEx Tissue Sample Gene Expression Profiles 1.0 1.05247 CAKI-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.924707 head of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0078 BD-04-NG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.73819 H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RWS6-2126-SM-2XCAV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22159 H3K79me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LOU-NH91 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.963975 phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.45085 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17592 raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.839738 TNFRSF13C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0267 AA-46-GL76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.301986 GSE135439_0_v_1_pax5_human RummaGEO Gene Perturbation Signatures 1.0 null SNU-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null EPB41L5 Pathway Commons Protein-Protein Interactions 1.0 null GSE210580_3_v_1_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null mRNA binding GO Molecular Function Annotations 2023 1.0 null dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.07555 CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX1-30185409-HPC-MOUSE-BONEMARROW-LEUKEMIA ChEA Transcription Factor Targets 2022 1.0 null CDC5L Pathway Commons Protein-Protein Interactions 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70V-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CPT1A Pathway Commons Protein-Protein Interactions 1.0 null H3K14ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null G142 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.896631 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LF-01A-21R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null RERF-GC-1B COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 EIF1AY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31995 MBD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100539_HIP_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.19801 CA-68-KG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.84676 GSE178292_0_v_3_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null Hep3B2-1-7 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.07454 GSE248770_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.428749 HEPG2 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 2.10964 medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.46802 H3K4me3_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SNUC5 DepMap CRISPR Gene Dependency 1.0 2.43346 NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17169 AA-68-OJ16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.765161 chr20_44900820_C_G_b38 GTEx eQTL 2025 1.0 1.21242 Precancerous Conditions CTD Gene-Disease Associations 1.0 1.16203 preoptic region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.11813 ANAPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.00123 periventricular stratum of r5Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12678 Eukaryotic translation initiation factor 2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.327 arcuate nucleus of medulla, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.21197 Perturb_6864_KO_CDK8_SRP299261 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.19796 CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.866536 GTEX-XQ8I-2026-SM-4BOOL GTEx Tissue Sample Gene Expression Profiles 1.0 1.0798 Lung squamous cell carcinoma_LUSC_TCGA-85-A510-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-IA-A40Y-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.521 PMC12717993-MEC-34-e17796-s002.xlsx-ST12_WGS_RFMix_genes_2_anc-Unnamed_14_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44583 IA-76-ZU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.79377 Accessory olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04786 YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular process GO Biological Process Annotations 2015 1.0 null Carcinogenesis DisGeNET Gene-Phenotype Associations 1.0 null superficial stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22546 Brain Lower Grade Glioma_LGG_TCGA-DU-5847-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE169152_3_v_1_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null Autosomal dominant nonsyndromic deafness 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.524 SR Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.15989 HCC4006 CCLE Cell Line Gene CNV Profiles -1.0 -1.91466 CHLA57 DepMap CRISPR Gene Dependency 1.0 3.10673 SAP30 ENCODE Transcription Factor Targets 1.0 null GSE126463_1_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null isthmus proper Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11077 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -3.47461 RNA cap binding complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.728 GSE156454_0_v_1_tamoxifen_human RummaGEO Drug Perturbation Signatures 1.0 null dorsal subdivision of VLC Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.953661 Lung adenocarcinoma_LUAD_TCGA-MN-A4N5-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HBEGF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20096 H4K20me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P4QS-2626-SM-2I3EV GTEx Tissue Sample Gene Expression Profiles 1.0 1.05008 H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Posterolateral visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28502 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MT-1026-SM-3TW8T GTEx Tissue Sample Gene Expression Profiles 1.0 0.949516 TCF12_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K20me1_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NKAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00547 GTEX-QESD-0526-SM-2I5G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37895 posterior part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27969 Essential tremor 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.357 PROSER2 Pathway Commons Protein-Protein Interactions 1.0 null OUMS23 CCLE Cell Line Gene Expression Profiles 1.0 1.41583 CTTN Pathway Commons Protein-Protein Interactions 1.0 null Perturb_3954_KD_SQLE_SRP323858 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -8.93355 Ovarian Neoplasms CTD Gene-Disease Associations 1.0 1.18915 ZNF384_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prelimbic area, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00672 POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HS 683 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HD-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_7552_OE_IL1RN_SRP300901 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.93249 AB-09-YX02_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.279864 Oviductal ampulla TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.567 GSE180321_0_v_1_imperatorin_human RummaGEO Drug Perturbation Signatures 1.0 null GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.37958 rnf2_20805357_megakaryocytic_l8057_lof_mouse_gpl1261_gse33659 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.246167 SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 3.1319 DC-51-WE27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.73971 RC-K8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.839529 ZNF781 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35514 GSE190384,GSE190386_6_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Casparian strip COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.091 Lung adenocarcinoma_LUAD_TCGA-L9-A444-01A-21R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null colorectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.381003 BB-87-SF89_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.30584 PELI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58926 POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null extracellular membrane-bounded organelle GO Cellular Component Annotations 2015 1.0 null Gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.677 GTEX-XOTO-0011-R11B-SM-4B64O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24338 CTCF_A549_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH716_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 4.34853 GSE202434,GSE202438_13_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null DD-42-PC65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.421649 vascular disease GWASdb SNP-Disease Associations 1.0 0.187918 caco2 HPA Cell Line Gene Expression Profiles 1.0 0.84832 pi-body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.824 HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.52003 HD-51-KD29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.307188 terete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05938 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.46765 hsa-miR-4656 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 FLG Pathway Commons Protein-Protein Interactions 1.0 null fat_e HPA Tissue Sample Gene Expression Profiles -1.0 -0.960135 EFO-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.942041 FF-86-NH56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.325464 QGP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.2197 pretectal nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.844295 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1 ENCODE Transcription Factor Targets 1.0 null STAT5A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HEC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE195559_0_v_7_notch1_human RummaGEO Gene Perturbation Signatures 1.0 null OVCAR433 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.07363 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WC-09-GD62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.472389 layer 1 of AOV cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64501 CTCF_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GIGYF1 Pathway Commons Protein-Protein Interactions 1.0 null TUBGCP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29015 reproductive process GO Biological Process Annotations 2015 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7752-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUND_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE178292_0_v_2_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GFAP Pathway Commons Protein-Protein Interactions 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7S9-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 496100519_HIP_probable Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.76052 Perturb_6850_OE_ZNF37A_SRP273660 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 11.2091 chr20_44906262_G_A_b38 GTEx eQTL 2025 1.0 1.7517 GSE202434,GSE202438_3_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26256 H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SF-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SALE CCLE Cell Line Gene Expression Profiles 1.0 2.56399 DD-71-LY65_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.274566 RAD21_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SE-0726-SM-2XCD7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.33378 KLF4-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CEBPB ENCODE Transcription Factor Targets 1.0 null GSE101239_4_v_6_valproic acid_mouse RummaGEO Drug Perturbation Signatures -1.0 null WC-09-GD62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.5451 EA-84-SC49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.471777 POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.15657 LTV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.15946 SK-MES-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.910001 basolateral nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02612 GTEX-WYJK-1726-SM-3NM9U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70342 methotrexate_homo sapiens_gpl570_gse11440 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-OXRK-0626-SM-2HMJ5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.32046 PMC9170563-12885_2022_9665_MOESM3_ESM.docx-0-Candidata_target_genes_of_CEBPB_7_CEBPB Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM12867_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null icSARA deltaORF6_12Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.16911 EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-0011-R11A-SM-2TF6J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.898403 H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-0626-SM-46MUI GTEx Tissue Sample Gene Expression Profiles 1.0 1.21027 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PG-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CC-70-BD07_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.261371 HAND2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.6696 Paraventricular hypothalamic nucleus, parvicellular division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66216 Prdm5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 27.2743 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR6A1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.037 GSE131649_4_v_10_hemin_human RummaGEO Drug Perturbation Signatures -1.0 null ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7217064-IJC-146-3354-s004.xlsx-Table_S5-Supplementary_Table_S5_Genes_significantly_upregulated_in_OC2-transfected_AGS_cell_compared_to_control_ONECUT2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QVJO-1325-SM-2S1QX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997822 GA-59-RW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.234967 orbital frontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.10855 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.01108 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RN64-1626-SM-48FD7 GTEx Tissue Sample Gene Expression Profiles 1.0 2.90628 H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RPS26 Pathway Commons Protein-Protein Interactions 1.0 null abnormality of lipid metabolism GWASdb SNP-Phenotype Associations 1.0 0.218899 A549_Sorafenib Tosylate_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0137012 CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEG5-0826-SM-2I5GF GTEx Tissue Sample Gene Expression Profiles 1.0 1.46722 CP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.881994 L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.38012 EGR1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.01847 parataenial nucleus of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01697 Accessory olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30719 Nuclear cap binding complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.155 paravermis of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.63063 r1 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.47195 Perturb_15526_KD_CPT1A_SRP292168 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.79613 RPL39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28536 THAP1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-1026-SM-4B64M GTEx Tissue Sample Gene Expression Profiles 1.0 1.07992 GTEX-PLZ4-2826-SM-3P617 GTEx Tissue Sample Gene Expression Profiles 1.0 1.24916 Congenital Abnormalities CTD Gene-Disease Associations 1.0 1.23106 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AF-01-FE42_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.492578 H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.864189 lateral part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83646 CTCF_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null UF-14-LK87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.336189 GTEX-R55F-1226-SM-2TF59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01914 central part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14578 deferasirox_homo sapiens_gpl570_gds3558 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.20285 PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null BL2262 (DOCK9) NURSA Protein Complexes 1.0 null NCI-H2023 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.860925 GSE134375_3_v_2_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null NFYB ENCODE Transcription Factor Targets 1.0 null GTEX-REY6-0326-SM-2TF5A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03223 MYO1C Pathway Commons Protein-Protein Interactions 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LJ-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE207282_1_v_0_polydatin_human RummaGEO Drug Perturbation Signatures -1.0 null anterior digastric muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30482 PD-70-VS77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.244397 POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KHDRBS1 Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RBM14 Pathway Commons Protein-Protein Interactions 1.0 null Sarcoma_SARC_TCGA-JV-A75J-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Medial septal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37934 Adrenocortical carcinoma_ACC_TCGA-P6-A5OG-01A-22R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.036 GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.31386 HDLM2 CCLE Cell Line Gene CNV Profiles -1.0 -2.09962 MAFF ENCODE Transcription Factor Targets 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null C170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZF-06A-12R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney Diseases CTD Gene-Disease Associations 1.0 1.31536 RAD21_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Posterodorsal preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06076 GSE252988_0_v_1_lefamulin_human RummaGEO Drug Perturbation Signatures 1.0 null PABPC3 Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6 Rummagene Transcription Factor Associations 2026 1.0 null GSE160817_3_v_6_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVN-0926-SM-2I5GL GTEx Tissue Sample Gene Expression Profiles 1.0 0.889225 PAAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.28429 Dorsomedial nucleus of the hypothalamus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.89108 H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Anterodorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61673 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null DB-74-HJ91_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218901 H3K4me3_Adipose Nuclei Roadmap Epigenomics Histone Modification Site Profiles 1.0 null VDR ChEA Transcription Factor Targets 1.0 null EVSAT CCLE Cell Line Gene CNV Profiles -1.0 -1.42276 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE89767_2_v_5_cebpa_mouse RummaGEO Gene Perturbation Signatures -1.0 null MPP-89 COSMIC Cell Line Gene Mutation Profiles 1.0 null CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE163240_3_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Y-79 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.771 cytoplasmic stress granule GO Cellular Component Annotations 2025 1.0 null SAM complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.936 MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null increased mean corpuscular hemoglobin MGI Mouse Phenotype Associations 2023 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Mammillary body Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27164 PRECLH CCLE Cell Line Gene Expression Profiles 1.0 2.80779 PK-59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.879612 H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NL3H-0011-R1a-SM-48TDJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.863089 Paraventricular hypothalamic nucleus, magnocellular division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.82204 RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A7J0-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COPB2 Pathway Commons Protein-Protein Interactions 1.0 null GSE215086_0_v_1_batf_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Duration Of Sleep DisGeNET Gene-Phenotype Associations 1.0 null Male reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.122 nucleus sagulum, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24384 Prostate adenocarcinoma_PRAD_TCGA-KC-A7FA-01A-21R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lysosomal storage disease GWASdb SNP-Disease Associations 1.0 0.383074 SIN3A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-205 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AD-34-TG29_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20121 PMC12069319-Table1.xlsx-OCAB_p40_BirA-Gene_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE175787_5_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03624 Leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.063 CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-A5HU-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_GM12801_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JB-75-NC66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.700521 GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.68149 GTEX-NL3H-0011-R7a-SM-2I3G5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.876625 NA-30-HS87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.78058 GSE239784_1_v_0_sat1_human RummaGEO Gene Perturbation Signatures 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-LB-A7SX-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null pancreas GeneRIF Biological Term Annotations 1.0 null GSE209582_1_v_3_chloroquine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE128730_4_v_5_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null COLO-818 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.06129 testes GeneRIF Biological Term Annotations 1.0 null RPL7A Pathway Commons Protein-Protein Interactions 1.0 null Bundle sheath TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.948 GSE202434,GSE202438_9_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE242555_1_v_0_fn3k_human RummaGEO Gene Perturbation Signatures -1.0 null H3K79me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.77831 GTEX-PVOW-0726-SM-2XCF5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.896292 isthmic part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16623 JE-22-JR20_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.279358 paraventricular nucleus, rostral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.14424 EGR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6056651__F7 PFOCR Pathway Figure Associations 2023 1.0 null CGN Pathway Commons Protein-Protein Interactions 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4352-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149264,GSE149267_4_v_5_trp53_mouse RummaGEO Gene Perturbation Signatures 1.0 null MSC JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.9733 rectum TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.783141 GSE114992,GSE114993_0_v_11_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null QA-50-YO37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.55339 GSE227592_13_v_3_adar_human RummaGEO Gene Perturbation Signatures -1.0 null Ribonucleoprotein granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.92 POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC13187244-41392_2026_2766_MOESM2_ESM.xlsx-Table_S17-Table_S17_Differentially_expressed_genes_in_OCI-AML3_cells_ZMIZ1_inhibitor_SIH-001_4E_vs_DMSO_RUNX2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RAD21_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BB-55-JH29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202466 NDUFA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01001 GTEX-SJXC-0726-SM-2XCFJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.59319 ZBTB7A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE190316,GSE190324_6_v_9_rbm4_human RummaGEO Gene Perturbation Signatures 1.0 null inner CP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.888756 CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12864_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FXR MotifMap Predicted Transcription Factor Targets 1.0 null ZNF638 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3056 H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Polysome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.744 ELMOD3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05015 POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Yb body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.506 CD-05-PU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.811034 HA-E2F1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormal oocyte morphology MPO Gene-Phenotype Associations 1.0 null H3K4me3_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-S3XE-0426-SM-3K2AC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.950486 GSE178907_0_v_3_fkrp_human RummaGEO Gene Perturbation Signatures 1.0 null NCIH1395 CCLE Cell Line Gene Expression Profiles -1.0 -2.13384 hsa-miR-3714 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 RD-90-OY66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.777733 GTEX-RWS6-0626-SM-2XCAS GTEx Tissue Sample Gene Expression Profiles 1.0 1.17675 H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE242049_1_v_0_glutathione_mouse RummaGEO Drug Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-KC-A7F5-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PW2O-1726-SM-2S1OO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18489 Nucleus of the lateral olfactory tract, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23288 K562_Sodium Phenylbutyrate_10µM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0141152 TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU1J-0226-SM-2TF5Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.955567 Perturb_12207_Mut_TP53_SRP287851 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.23896 DE-81-OY65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.296503 GSE209938_0_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null PIK3R4 Pathway Commons Protein-Protein Interactions 1.0 null Ventral premammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43409 increased secondary ovarian follicle number MPO Gene-Phenotype Associations 1.0 null PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_9_v_5_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_CD8 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.386 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MELHO DepMap CRISPR Gene Dependency 1.0 2.38091 organic cyclic compound metabolic process GO Biological Process Annotations 2015 1.0 null Large intestine cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.409 GSE255432_6_v_2_imeglimin_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.89434 GSE181521_0_v_1_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null FC-56-ZH16_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222459 SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.842654 Psoas_Muscle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.07206 BT-474 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199204,GSE211619_4_v_7_glutamine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE111247_2_v_6_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.8662 DPF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23538 RAD21_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cholesterol embolism GWASdb SNP-Disease Associations 1.0 0.757675 BCL3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPVG-0826-SM-4B654 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.996934 Acute Myeloid Leukemia_LAML_TCGA-AB-2990-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-DX-A7EO-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC10350819-EMBJ-42-e113168-s003.pdf-14-ENSG00000164048_ZNF589 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Polyadenylate-binding protein/Hyperplastic disc protein InterPro Predicted Protein Domain Annotations 1.0 null GSE128730_7_v_5_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE213228_1_v_3_irak2_human RummaGEO Gene Perturbation Signatures -1.0 null CDK11A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44563 GSE118077_4_v_2_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_Duodenum Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PROX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.7467 MEWO COSMIC Cell Line Gene Mutation Profiles 1.0 null lymphnode_5c HPA Tissue Sample Gene Expression Profiles 1.0 1.51258 GTEX-NPJ8-0326-SM-2D7VV GTEx Tissue Sample Gene Expression Profiles 1.0 1.42443 GSE234514,GSE234516_2_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null HS695T DepMap CRISPR Gene Dependency 1.0 7.74291 VZ in ventromedial extrastriate cortex (VP) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.833412 PMC10794847-mmc5.xlsx-PIAS1_KD_down-Table_S4_Differentially_expressed_genes_with_PIAS1_knockdown_in_the_progenitors_state_Related_to_Figure_5_AR Rummagene Transcription Factor Associations 2026 1.0 null decreased germ cell number MPO Gene-Phenotype Associations 1.0 null PMC5105166-ncomms13331-s11.xlsx-Sheet1-Supplementary_Data_10_Overlap_of_upregulated_genes_in_MEF2D-rearranged_cases_with_public_ChIPseq_RNAseq_data_MEF2D Rummagene Transcription Factor Associations 2026 1.0 null Ventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14729 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70P-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8302_KD_RBM22_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.82085 cytoplasmic stress granule GO Cellular Component Annotations 2023 1.0 null GSE159049_1_v_0_sox2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE242290_1_v_11_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null GSE81796_0_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null ZR-75-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.94197 CEBPB ChEA Transcription Factor Targets 1.0 null CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hypothalamic medial zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35399 GSE140092_0_v_1_socs3_mouse RummaGEO Gene Perturbation Signatures -1.0 null JUND ENCODE Transcription Factor Targets 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5374-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JIMT-1 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 GSE179031_3_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BD-49-MD69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.02234 HD-19-IW09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.247276 RAD21_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100478_HIP_dementia_TBI_86_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.14688 HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PABPC5 Pathway Commons Protein-Protein Interactions 1.0 null EYA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1534 GSE80098,GSE80366_0_v_6_progesterone_human RummaGEO Drug Perturbation Signatures 1.0 null NOCT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79454 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UL-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null P-body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.724 CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMTN Pathway Commons Protein-Protein Interactions 1.0 null GATA3 ENCODE Transcription Factor Targets 1.0 null HCC630 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07956 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158632_2_v_5_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null pontine raphe nucleus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.35628 GTEX-TML8-1826-SM-32QOR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61606 Retinoblastoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.528 PCIF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07998 GTEX-WOFL-0726-SM-3MJG4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2216 BRD8 Pathway Commons Protein-Protein Interactions 1.0 null posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29331 disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.038552 roof plate of p2 (epithalamic roofplate) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.52339 HCC461 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.991307 BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-A5G7-01B-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in dorsomedial extrastriate cortex (V2) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.856319 EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PKP3 Pathway Commons Protein-Protein Interactions 1.0 null chr20_44909016_T_A_b38 GTEx eQTL 2025 1.0 1.45403 Blastocyst TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.455 retromammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20228 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EX-A1H6-01B-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CC-09-YG11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210713 Edinger-Westphal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.40698 GTEX-X4LF-0426-SM-3NMB5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.18782 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RB-55-KL42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.226181 HCC38 CCLE Cell Line Gene CNV Profiles 1.0 1.42342 Hs-633T Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.37854 NO11 DepMap CRISPR Gene Dependency 1.0 6.48024 VZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15033 posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.37606 abnormal oocyte number MPO Gene-Phenotype Associations 1.0 null SMC3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null EFM-192C Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06635 HS766T CCLE Cell Line Gene CNV Profiles 1.0 2.12394 GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6992 H3K9ac_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Ectorhinal area/Layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04793 Paraventricular hypothalamic nucleus, magnocellular division, medial magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8931 POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HQ-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mRNA binding GO Molecular Function Annotations 2025 1.0 null cerebellar cortex_35 pcw_F_12295 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.79573 GTEX-PLZ4-1226-SM-2I5FE GTEx Tissue Sample Gene Expression Profiles 1.0 2.21288 GTEX-P4PQ-2626-SM-33HC9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07513 PMC6684323-NIHMS1532201-supplement-Table_S6.xlsx-LPS-Sup_Table_6C_Delta_PVE_among_PopDE_genes_LPS_PopDE_FDR_0_2_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_37 pcw_M_263195015 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.70073 UACC893 CCLE Cell Line Gene Expression Profiles -1.0 -1.779 RCH-ACV COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-T2IS-2926-SM-32QPO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.945691 DDX3X Pathway Commons Protein-Protein Interactions 1.0 null H3K9ac_Breast Myoepithelial Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null including GeneRIF Biological Term Annotations 1.0 null Ovarian follicle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.565 GSE158834_12_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_5643_KD_SOX2_SRP174102 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBJ-0326-SM-33HBO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.897607 VZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.66657 H3K27me3_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null poly(U) RNA binding GO Molecular Function Annotations 2023 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SARS-dORF6_24Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.742779 BICD1 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-62-A46V-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CUX1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-2026-SM-47JX8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.70666 PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PAX5 ENCODE Transcription Factor Targets 1.0 null GTEX-TSE9-0526-SM-3DB7Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.10065 Nuclear speck COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.097 ELF1 ENCODE Transcription Factor Targets 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null YMB1 CCLE Cell Line Gene Expression Profiles -1.0 -1.77011 A4 noradrenergic cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31695 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IF-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AH-1826-SM-2S1Q2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09322 KURAMOCHI COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYVS-0326-SM-3NM9V GTEx Tissue Sample Gene Expression Profiles 1.0 1.57096 LRRC59 Pathway Commons Protein-Protein Interactions 1.0 null ACP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.70345 GTEX-WYBS-0926-SM-3NM94 GTEx Tissue Sample Gene Expression Profiles 1.0 1.33305 external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34302 MAT2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08153 CTCF_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-0526-SM-2I3EH GTEx Tissue Sample Gene Expression Profiles 1.0 1.93977 GTEX-WFG7-0726-SM-3GIKO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09327 Oculopharyngodistal myopathy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.646 GSE128240_0_v_1_cyclophosphamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null UKE-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.75006 JC-06-ED36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.20619 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QE-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abnormality of cholesterol metabolism GWASdb SNP-Phenotype Associations 1.0 0.656005 SNU423_LIVER CCLE Cell Line Proteomics 1.0 2.43113 EB-09-OC36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248609 GTEX-U3ZH-1926-SM-4DXTR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92431 CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_351_OE_CD274_SRP287831 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.87581 Cytoplasmic side of nuclear pore COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.355 BL3961 (PES1) NURSA Protein Complexes 1.0 null Blastomere TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.149 Miracidium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.85 TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.93707 TCEAL8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.34982 SYK_druginhibition_282_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.58769 GSE102187_0_v_1_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMEM179B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23486 GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41561 GTEX-WWYW-0826-SM-3NB2X GTEx Tissue Sample Gene Expression Profiles 1.0 2.8264 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null GSE229973_3_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Subparaventricular zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53937 NR2F2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE207302,GSE207303_0_v_2_tp53bp2_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WH7G-0426-SM-3NMBJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.984591 EGR1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Oligospermia CTD Gene-Disease Associations 1.0 1.02783 striatum_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.07721 Perturb_8842_KD_ESRRA_SRP254908 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 hsa-miR-4478 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWCY-0526-SM-2I3ER GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12546 GSE183041_1_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HX-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF143 ENCODE Transcription Factor Targets 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4351-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BL7356 (WDR89) NURSA Protein Complexes 1.0 null GSE160817_2_v_8_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null impaired fertilization MPO Gene-Phenotype Associations 1.0 null EFM192A CCLE Cell Line Gene CNV Profiles -1.0 -1.49371 Lung adenocarcinoma_LUAD_TCGA-78-7167-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.04071 SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE205630_0_v_1_gmds_human RummaGEO Gene Perturbation Signatures -1.0 null Retinitis pigmentosa 62 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.506 MAX ENCODE Transcription Factor Targets 1.0 null GATA4_INACTIVATION_GDS3663_519_mouse_Endothelial-derived cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PRDX4 Pathway Commons Protein-Protein Interactions 1.0 null AC-50-FR41_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.431581 abnormal fertilization MPO Gene-Phenotype Associations 1.0 null GSE247775_1_v_0_tmprss2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC6684084-pntd.0007589.s007.xlsx-Sky_Blue_Module-NFYA_NFYA Rummagene Transcription Factor Associations 2026 1.0 null EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 537 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.886626 ECC12 CCLE Cell Line Gene CNV Profiles 1.0 2.26894 paclitaxel_homo sapiens_gpl570_gse11550 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null basal part of terminal hypothalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03066 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17389037-Tab6 GeneSigDB Published Gene Signatures 1.0 null plexiform layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32344 intermediate stratum of PcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40859 t47d HPA Cell Line Gene Expression Profiles 1.0 1.56518 Sarcoma_SARC_TCGA-SG-A6Z7-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050762 TE8 CCLE Cell Line Gene CNV Profiles 1.0 1.75762 ZNF667 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.957 abnormal ovarian folliculogenesis MPO Gene-Phenotype Associations 1.0 null 496100604_HIP_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.03048 Accessory olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61797 THOC6 Pathway Commons Protein-Protein Interactions 1.0 null r5 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12678 GSE123002_0_v_1_srsf3_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anterior olfactory nucleus, external part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31926 Cyclin B1-CDK1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.036 superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.84845 KON COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 MYBL2 ENCODE Transcription Factor Targets 1.0 null GTEX-PX3G-2626-SM-2I3EG GTEx Tissue Sample Gene Expression Profiles 1.0 0.998088 PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2IS-2026-SM-4DM6W GTEx Tissue Sample Gene Expression Profiles 1.0 1.14175 ESR1 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153189_1_v_3_interferon gamma_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-QLQ7-0526-SM-2I5G3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05219 H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC10350819-EMBJ-42-e113168-s007.pdf-108-ZNF589_ZNF589 Rummagene Transcription Factor Associations 2026 1.0 null HS939-T COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE133661_0_v_1_c19orf12_human RummaGEO Gene Perturbation Signatures -1.0 null Aflatoxin B1 CTD Gene-Chemical Interactions 1.0 null BA-56-QV45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.264169 GTEX-X4XY-0826-SM-4E3JM GTEx Tissue Sample Gene Expression Profiles 1.0 2.53724 EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.32717 hsa-miR-3929 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles -1.0 -2.42821 VZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.34312 medial nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.890558 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner CP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12844 EVSA-T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.07681 Nr5a1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 23.6964 Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81W-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_WI38_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1 ENCODE Transcription Factor Targets 1.0 null LAS1L Pathway Commons Protein-Protein Interactions 1.0 null GSE247764_0_v_2_nell2_mouse RummaGEO Gene Perturbation Signatures -1.0 null anteroventral nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06873 ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null HCFC1 ENCODE Transcription Factor Targets 1.0 null GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60091 HEL9217 DepMap CRISPR Gene Dependency 1.0 4.77684 GSE143944_2_v_0_ribociclib_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3471-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-4_E2F8-Gene_E2F8 Rummagene Transcription Factor Associations 2026 1.0 null GSE96777,GSE96778_1_v_0_zbtb4_human RummaGEO Gene Perturbation Signatures 1.0 null arcuate nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.964109 GSE207135_1_v_0_sod2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE81796_0_v_1_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null S0-EE-Y97N_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.385003 lambdoid septal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3726 LSM7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10541 Head and Neck squamous cell carcinoma_HNSC_TCGA-WA-A7GZ-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211262,GSE211263_2_v_1_pbrm1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE226397_0_v_1_cystine_mouse RummaGEO Drug Perturbation Signatures -1.0 null KM-12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.24924 Tubulin folding cofactor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.383 Liver hepatocellular carcinoma_LIHC_TCGA-RC-A7SK-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC6420765-12864_2019_5550_MOESM4_ESM.xlsx-R_D9_vs_D15-gene_id_y_CENPX Rummagene Transcription Factor Associations 2026 1.0 null outer SZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.876444 GSE210682_0_v_3_methadone_human RummaGEO Drug Perturbation Signatures -1.0 null HNT34 CCLE Cell Line Gene CNV Profiles -1.0 -2.17647 GTEX-WEY5-1926-SM-3GIL8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852508 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3426-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JE-22-JR20_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.362696 Intersegmental muscle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.695 RH30 CCLE Cell Line Gene Expression Profiles -1.0 -1.71573 POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P44H-0426-SM-2XCEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3479 GTEX-WHSB-1626-SM-3LK6J GTEx Tissue Sample Gene Expression Profiles 1.0 1.10066 GSE171572_1_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF-21964334-BJAB-B-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.70211 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OB-17-DQ74_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.386663 Prostate adenocarcinoma_PRAD_TCGA-M7-A71Z-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE200839,GSE233826_5_v_4_tnrc18_human RummaGEO Gene Perturbation Signatures 1.0 null RAD21_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-548m TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.21925 tardbp_19910924_hek293e_lof_human_gpl570_gds3730 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.262501 TE-26-XS06_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.262736 NFATC1 ENCODE Transcription Factor Targets 1.0 null GTEX-XQ8I-1726-SM-4BOQB GTEx Tissue Sample Gene Expression Profiles 1.0 1.06542 Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE178340_5_v_2_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_LNCaP clone FGC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Secondary cell wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.041 CTCF_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SLC12A7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14118 abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.2364 Hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 Nucleus y Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.77188 MED24 Pathway Commons Protein-Protein Interactions 1.0 null PMC10760404-NIHMS1688779-supplement-Supplementary_Table_S6.xlsx-EMP_CREB_Targets-symbol_CREB1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_mammary epithelial cell_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null external granular (germinal) layer of upper rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.44324 VZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.52173 HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2BK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_Stomach Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77034 hsa-miR-3652 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 KATOIII Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.07029 RBM43 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-human_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PWN1-1626-SM-2S1OL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37815 GSE153867_6_v_4_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T5JW-2026-SM-4DM63 GTEx Tissue Sample Gene Expression Profiles 1.0 0.912367 GTEX-XPT6-0126-SM-4B65S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02346 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE193993_1_v_7_sstr2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QCQG-0008-SM-48U2G GTEx Tissue Sample Gene Expression Profiles 1.0 0.886977 KNS42 DepMap CRISPR Gene Dependency 1.0 2.41273 H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U3ZH-1426-SM-4DXSR GTEx Tissue Sample Gene Expression Profiles 1.0 1.01072 mRNA cleavage and polyadenylation specificity factor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.788 periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.97809 disease of metabolism GWASdb SNP-Disease Associations 1.0 0.101417 BCL6B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.10023 GTEX-S4Q7-1026-SM-4AD75 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21848 H3K4me3_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null intermediate periretromammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47033 HCC1263 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.826121 GSE102467_1_v_2_pazopanib_human RummaGEO Drug Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29331 FA-80-DR66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.250731 GSE178907_5_v_3_fkrp_human RummaGEO Gene Perturbation Signatures 1.0 null Superior olivary complex, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26118 CTCF_GM12864_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.51726 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-P4PP-0326-SM-33HC4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1799 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_9004_KD_C19orf12_SRP212737 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -9.95656 H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K79me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE249098_3_v_2_mthfd1l_human RummaGEO Gene Perturbation Signatures -1.0 null E2F4 ENCODE Transcription Factor Targets 1.0 null Mesophyll TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.935 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null mRNA 3'-UTR binding GO Molecular Function Annotations 2023 1.0 null POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLNB Pathway Commons Protein-Protein Interactions 1.0 null POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DA-35-DU85_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.583804 POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WYVS-1726-SM-3NMAY GTEx Tissue Sample Gene Expression Profiles 1.0 1.27869 SLC9A3_KO_GDS3323_495_mouse_colon GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE182680,GSE182683_7_v_9_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.88555 MRPL45 Pathway Commons Protein-Protein Interactions 1.0 null UBD Pathway Commons Protein-Protein Interactions 1.0 null GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GSE201110_0_v_1_sirt4_human RummaGEO Gene Perturbation Signatures -1.0 null Messenger ribonucleoprotein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.308 RPS13 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-UTHO-0011-R11A-SM-3GIJE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08746 ACCMESO1 DepMap CRISPR Gene Dependency 1.0 3.19602 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.993528 H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU2F2_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213650_3_v_2_everolimus_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ventromedial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08625 GTEX-T6MO-0226-SM-32QOL GTEx Tissue Sample Gene Expression Profiles 1.0 0.986557 GSE114883_1_v_4_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null RAD21_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE227698_5_v_0_g0s2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE229973_4_v_5_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-V1D1-0926-SM-4JBHQ GTEx Tissue Sample Gene Expression Profiles 1.0 3.2086 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24541 GSE110580_1_v_0_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null PMC11373733-ABR-13-34_Suppl1.pdf-283-ZNF138_ZNF138 Rummagene Transcription Factor Associations 2026 1.0 null 1321N1 CCLE Cell Line Gene CNV Profiles 1.0 1.64901 GSE152441,GSE152442_0_v_4_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null mantle zone of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75854 abnormal secondary ovarian follicle number MPO Gene-Phenotype Associations 1.0 null SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null paraventricular nucleus, peduncular or principal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93322 GSE102467_3_v_2_pazopanib_human RummaGEO Drug Perturbation Signatures 1.0 null ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null QGP1 CCLE Cell Line Gene CNV Profiles -1.0 -1.36634 UBR4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04302 lateral part of MM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48935 MOLM6 CCLE Cell Line Gene CNV Profiles -1.0 -2.5312 Perturb_2736_KD_Smyca_SRP330233 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.96371 ZNF189 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.5754 GSE213611_1_v_0_nuf2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null FOXA1 ENCODE Transcription Factor Targets 1.0 null GSE114883_0_v_5_romidepsin_human RummaGEO Drug Perturbation Signatures 1.0 null RAD21_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_3360_KO_Bach2_SRP267100 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.60763 GSE201270,GSE201272_5_v_1_mybl2_human RummaGEO Gene Perturbation Signatures 1.0 null Urinary tract infection DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.034 Cytosolic ribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.551 Schizont TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.849 Elagolix sodium_C-33 A Tahoe Therapeutics Tahoe 100M Perturbation Atlas 1.0 0.0143353 GSE247764_1_v_2_nell2_mouse RummaGEO Gene Perturbation Signatures -1.0 null DA-07-LL18_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.239014 Arid3a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.2222 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YJ-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SARS-BatSRBD_0Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.72249 GSE160304,GSE163392_0_v_3_zswim8_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_12208_Mut_TP53_SRP287851 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.48271 cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.78184 GSE193402_0_v_1_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null MYBBP1A Pathway Commons Protein-Protein Interactions 1.0 null GSE190384,GSE190386_1_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null EC-89-AJ93_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.23171 LCLC103H DepMap CRISPR Gene Dependency 1.0 2.93494 GTEX-WL46-2826-SM-3LK81 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16311 MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08928 GSE123638,GSE123639_2_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-93-A4JN-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE190316,GSE190324_1_v_11_rbm4_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_SK-N-SH_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.69411 HT-144 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09659 MYL6 Pathway Commons Protein-Protein Interactions 1.0 null Endodeoxyribonuclease complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.583 MYLK2 Pathway Commons Protein-Protein Interactions 1.0 null POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_Brain Germinal Matrix Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cardiac muscle cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M6-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SMC3 ENCODE Transcription Factor Targets 1.0 null AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.593187 Ribonucleoprotein granule COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 GSE149123,GSE149128_1_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null AMO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01961 GTEX-R55D-1426-SM-48FEN GTEx Tissue Sample Gene Expression Profiles 1.0 1.07123 BT-474 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PLAUR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16864 Muscle tissue disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.855 Sertoli cell-only syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.282 CTCF_MCF-7_hg19_9 ENCODE Transcription Factor Binding Site Profiles 1.0 null AM38 DepMap CRISPR Gene Dependency 1.0 2.72852 GSE224131_2_v_1_mafb_human RummaGEO Gene Perturbation Signatures -1.0 null mRNA cleavage stimulating factor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.952 SNU719 CCLE Cell Line Gene Expression Profiles -1.0 -1.53689 PMC10542516-media-7.xlsx-EPC_siCTL_vs_EPC_SMAD1-5_Sample-symbol_SMAD1 Rummagene Transcription Factor Associations 2026 1.0 null CHM Pathway Commons Protein-Protein Interactions 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70W-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U3-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r2Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22369 GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3129 GTEX-VUSG-0426-SM-3GIKD GTEx Tissue Sample Gene Expression Profiles 1.0 1.35192 H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AA-86-YY62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.314261 GSE231799_2_v_4_nfkbie_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE227698_5_v_3_g0s2_human RummaGEO Gene Perturbation Signatures -1.0 null REST_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hematologic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.052 CTCF_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T2IS-2626-SM-32QPP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67315 RISC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.246 H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Small ribosomal subunit COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.651 GSE202825_2_v_1_ano1_human RummaGEO Gene Perturbation Signatures -1.0 null abnormal internal female genitalia morphology MPO Gene-Phenotype Associations 1.0 null NEUROD2-26341353-CORTEX-MOUSE ChEA Transcription Factor Targets 2022 1.0 null skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -1.27958 H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null u937 HPA Cell Line Gene Expression Profiles -1.0 -1.47892 CTCF_GM12864_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOT4-0726-SM-4GIAW GTEx Tissue Sample Gene Expression Profiles 1.0 0.870183 rna polyadenylation GO Biological Process Annotations 2015 1.0 null CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.871521 LRRC1 Pathway Commons Protein-Protein Interactions 1.0 null RD-90-OY66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.341439 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null single-organism cellular process GO Biological Process Annotations 2015 1.0 null GSE228430_2_v_3_fabp5_human RummaGEO Gene Perturbation Signatures 1.0 null Adenocarcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.067 PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-E_ATF4-def_vs_HCT116_Tg8-Unnamed_1_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null GSE159893_2_v_0_genistein_human RummaGEO Drug Perturbation Signatures 1.0 null RPS25 Pathway Commons Protein-Protein Interactions 1.0 null NFATC1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158458_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE148066,GSE157787_11_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null ZNF846 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26565 Adrenocortical carcinoma_ACC_TCGA-OR-A5L6-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dorsomedial nucleus of the hypothalamus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.88187 HDAC1 ENCODE Transcription Factor Targets 1.0 null HUTU80 CCLE Cell Line Gene Expression Profiles 1.0 1.43124 EFO21 CCLE Cell Line Gene Expression Profiles 1.0 2.03303 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-8070-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MBD4_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null GSE211286_1_v_5_tcf12_mouse RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-1626-SM-32PLS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14843 GTEX-UPIC-0926-SM-4IHLV GTEx Tissue Sample Gene Expression Profiles 1.0 1.39023 kidney_c HPA Tissue Sample Gene Expression Profiles 1.0 0.875062 GSE197850_4_v_3_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null immature GeneRIF Biological Term Annotations 1.0 null CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RN64-0626-SM-2TC5V GTEx Tissue Sample Gene Expression Profiles 1.0 2.22532 H3K4me3_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.69315 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4819-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_14372_KD_IGF2BP3_SRP131243 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.16455 POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anterior hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03577 TCF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1252 NCIH1755 CCLE Cell Line Gene Expression Profiles -1.0 -1.53458 GTEX-S4Z8-1826-SM-3K2BH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1357 WE-43-PZ45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.300833 PMC10350819-EMBJ-42-e113168-s003.pdf-14-ZNF589_ZNF589 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XXEK-1326-SM-4BRV1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.990286 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8SJ-01B-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KINGS1 DepMap CRISPR Gene Dependency 1.0 2.13405 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_9_v_13_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null Cytoplasmic stress granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.717 PBX3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BC-62-RZ55_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.338725 MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPRR1B Pathway Commons Protein-Protein Interactions 1.0 null GSE153354_0_v_1_tcf19_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XMK1-1026-SM-4B65H GTEx Tissue Sample Gene Expression Profiles 1.0 0.829655 detected GeneRIF Biological Term Annotations 1.0 null GTEX-Q2AG-0326-SM-48U1O GTEx Tissue Sample Gene Expression Profiles 1.0 1.30926 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE113817_0_v_1_bach1_human RummaGEO Gene Perturbation Signatures 1.0 null DA-20-VR86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.65717 Rectum adenocarcinoma_READ_TCGA-DY-A1DG-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Potassium ion-transporting ATPase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.871 GATAD2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.5601 primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.830125 GTEX-XAJ8-0626-SM-47JY4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.824016 PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RABEP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.3959 RFX5 ENCODE Transcription Factor Targets 1.0 null intermediate stratum of DgSe Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09445 496100538_HIP_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.49005 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12775252-18_2025_5991_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_2_Up-_and_down-regulated_genes_in_TCF7L2-depleted_EVT_compared_to_control_EVT_TCF7L2 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4697-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMC3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null perilemniscal isthmic area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16173 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63U-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NN-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE197630_1_v_0_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDK9_druginhibition_183_GSE48258 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 0.113074 H3K4me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.25305 ventromedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.2105 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EZH2_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCM1 CCLE Cell Line Gene Expression Profiles 1.0 1.69459 IM95_STOMACH CCLE Cell Line Proteomics 1.0 3.19383 SW1417 CCLE Cell Line Gene CNV Profiles 1.0 1.67343 H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WVLH-0011-R11A-SM-3MJFO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.965087 GSE221327_4_v_0_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RVPV-0011-R11A-SM-2TF6F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14864 HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02866 mrna processing GO Biological Process Annotations 2015 1.0 null NCIH1781 CCLE Cell Line Gene Expression Profiles -1.0 -2.16978 H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Skin - Sun Exposed (Lower leg) GTEx Tissue Gene Expression Profiles 2023 1.0 2.46176 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MOLP-8 COSMIC Cell Line Gene Mutation Profiles 1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null GTEX-S7SF-0226-SM-3K2BI GTEx Tissue Sample Gene Expression Profiles 1.0 1.24539 PMC6336197-NIHMS1515792-supplement-Table_S1.xlsx-Differentially_exp_d_genes-Supplemental_Table_S1_ICGS_identified_2_368_genes_that_are_differentially_expressed_between_CMP_MEP_MKP_and_ERP_ELK3 Rummagene Transcription Factor Associations 2026 1.0 null GI-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.4564 CTCF_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R3RS-0526-SM-3GADG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07483 GTEX-QMRM-0526-SM-2I5GA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33391 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC15 CCLE Cell Line Gene CNV Profiles -1.0 -1.64296 CTCF_fibroblast of foreskin _hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SJXC-2026-SM-4DM6N GTEx Tissue Sample Gene Expression Profiles 1.0 0.996287 CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK3_01_318 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60731 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC5894239-12864_2018_4591_MOESM9_ESM.xlsx-ST12_mir_downregulated-Gene_name_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AH-0226-SM-48U1I GTEx Tissue Sample Gene Expression Profiles 1.0 1.00529 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.479 H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.86081 POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A3HE-01A-21R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_10434_KO_PPFIA1_SRP127326 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.91165 H3K79me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S32W-1326-SM-4AD5Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.916746 CTCF-27219007-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null POLR2A_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28325 H3K4me3_Penis Foreskin Fibroblast Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE206516,GSE206518_3_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures 1.0 null PMC4470057-12943_2015_398_MOESM7_ESM.xls-probes_KD_inh_in_common-SYMBOL_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRO-1226-SM-48TDL GTEx Tissue Sample Gene Expression Profiles 1.0 2.54443 CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.55999 CTCF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null CL40 CCLE Cell Line Gene Expression Profiles -1.0 -1.76512 SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE191015_1_v_3_gsdmb_human RummaGEO Gene Perturbation Signatures 1.0 null GSE159473_0_v_1_eif5a2_human RummaGEO Gene Perturbation Signatures -1.0 null Aorta Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -2.24162 Perturb_12718_KD_KMT2C_SRP110043 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 PROX1_01_06 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59211 FE-56-PV35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.296457 dorsomedial part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.73491 Perturb_7485_OE_Mir489_SRP155560 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -10.074 RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CGTH-W-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.11931 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null mrna metabolic process GO Biological Process Annotations 2015 1.0 null Perturb_10149_KO_FOXK1_SRP251223 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -18.5376 Prostate disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.139 H3K4me1_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE126463_1_v_2_arid2_human RummaGEO Gene Perturbation Signatures 1.0 null RAB3A_KO_GDS2483_700_mouse_Cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE145249_1_v_2_ppm1g_human RummaGEO Gene Perturbation Signatures -1.0 null RPS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04088 GTEX-U3ZN-2226-SM-3DB88 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43155 NCI-H1734 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H3K4me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YM-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KB-46-EJ60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.272701 SRF ENCODE Transcription Factor Targets 1.0 null Major depressive disorder DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.742 CREB3L1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.58075 GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15408 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.825793 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U9-06A-11R-A32P-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PL4 DepMap CRISPR Gene Dependency 1.0 2.21938 PMC6433273-pone.0214296.s009.xlsx-Table_D-S4_Table_Differentially_expressed_mRNAs_in_human_primary_monocytes_after_24_hours_of_LPS_stimulation_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.991307 MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE60217_1_v_10_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LB-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1869 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08018 RPS27L Pathway Commons Protein-Protein Interactions 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-AA3A-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4UY-0526-SM-3K2AN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69646 Cerebellar nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28333 membrane-bounded vesicle COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 GTEX-XQ8I-1926-SM-4BOOK GTEx Tissue Sample Gene Expression Profiles 1.0 0.911701 GTEX-X4XY-1026-SM-46MVX GTEx Tissue Sample Gene Expression Profiles 1.0 0.950555 hsa-miR-885-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GTEX-Q2AH-0726-SM-2I3EA GTEx Tissue Sample Gene Expression Profiles 1.0 1.31911 H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null 90S preribosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.658 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.903132 GTEX-XV7Q-1326-SM-4BRWM GTEx Tissue Sample Gene Expression Profiles 1.0 1.46248 HSPA6 Pathway Commons Protein-Protein Interactions 1.0 null eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE178267_2_v_0_vemurafenib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE221327_5_v_11_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null GTEX-XMD1-2826-SM-4AT5F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.906355 COLO 320DM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.88555 CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.95673 Brain Lower Grade Glioma_LGG_TCGA-DU-A76L-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FNTA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.10943 single organism reproductive process GO Biological Process Annotations 2015 1.0 null HOS Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.78653 extracellular vesicular exosome COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 Prostate adenocarcinoma_PRAD_TCGA-EJ-A7NH-01A-12R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE171486_4_v_6_ddx6_human RummaGEO Gene Perturbation Signatures -1.0 null UTP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31829 ZSCAN31 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.7485 FC-85-OX77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.288349 GTEX-SNMC-0126-SM-2XCFO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15937 15374961-TableS2 GeneSigDB Published Gene Signatures 1.0 null JKAMP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35113 SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158632_3_v_1_oxyquinoline_human RummaGEO Drug Perturbation Signatures -1.0 null NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.911168 mantle zone of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.18682 CTCF_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Immune System Diseases CTD Gene-Disease Associations 1.0 1.11911 isthmic liminal reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33938 PA-75-VL17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.437988 Perturb_14554_OE_SIRT4_SRP371292 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-OXRO-0011-R9A-SM-3NB1X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.902716 GTEX-WXYG-2526-SM-3NB3F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46896 HEATR4 Pathway Commons Protein-Protein Interactions 1.0 null rostral interstitial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05172 Brain Lower Grade Glioma_LGG_TCGA-KT-A7W1-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NRIP1 Pathway Commons Protein-Protein Interactions 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4TD-01A-32R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null polyovular ovarian follicle MGI Mouse Phenotype Associations 2023 1.0 null GSE193402_0_v_3_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null PSMD1 Pathway Commons Protein-Protein Interactions 1.0 null Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.126 Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endocrine/exocrine gland phenotype MPO Gene-Phenotype Associations 1.0 null doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE195663_0_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42061 IZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.58357 SARS-dORF6_0Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.1931 Orbital area, lateral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10539 Entorhinal area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18161 BC-10-SB73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.285278 SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XMD1-0011-R11A-SM-4AT5J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80157 H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-YL-A8SH-01B-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12621392-12864_2025_12212_MOESM2_ESM.xlsx-GSF-F_72h_1-Unnamed_0_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null KYSE-140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.42061 FBXO9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00174 CPSF6 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-RU1J-1726-SM-2TF5S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15443 locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.29505 NUGC-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.871091 Sarcoma_SARC_TCGA-FX-A8OO-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XQ8I-0626-SM-4BOPT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.902275 H3K27ac_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WFG7-2226-SM-3GIKP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21584 CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.58552 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial (fastigial) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00926 ZFP42 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23038 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.13347 primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.30419 AB-18-YN11_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.667655 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JO-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 1 of RSC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13459 GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -2.76512 STAT1 ENCODE Transcription Factor Targets 1.0 null GSN Pathway Commons Protein-Protein Interactions 1.0 null GTEX-T8EM-0226-SM-3DB7C GTEx Tissue Sample Gene Expression Profiles 1.0 0.925116 Adrenocortical carcinoma_ACC_TCGA-OR-A5JS-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLR20 CCLE Cell Line Gene Expression Profiles 1.0 1.71905 GSE182680,GSE182683_5_v_13_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE206729_3_v_0_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null BL5345 (PTPN12) NURSA Protein Complexes 1.0 null HCFC1 Pathway Commons Protein-Protein Interactions 1.0 null perimammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75918 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.883413 Trunk TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.037 r3 part of parvicellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47234 MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100359_PCx_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.19849 GSE218500_0_v_3_ruxolitinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null FF-54-JC89_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.349063 SMN2 Pathway Commons Protein-Protein Interactions 1.0 null inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12062 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NPJ8-1926-SM-3MJGB GTEx Tissue Sample Gene Expression Profiles 1.0 0.845586 GTEX-SIU7-1126-SM-2XCDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.01305 Zygote TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.345 POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null amygdaloid complex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.922688 Lung adenocarcinoma_LUAD_TCGA-J2-A4AD-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28473 Prostate adenocarcinoma_PRAD_TCGA-KC-A7F6-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.02654 GTEX-N7MS-2526-SM-2D7W3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.92218 GSE94849_7_v_4_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.41811 ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YF-77-FV50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.365982 intermediate part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03989 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MW-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12055596-41375_2025_2570_MOESM4_ESM.xlsx-PDX1-Unnamed_13_PDX1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XYKS-0226-SM-4BRW3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.914186 NR3C1 JASPAR Predicted Transcription Factor Targets 1.0 null ABCC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19706 BA-84-TD72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.303941 H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6997-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Vermiform appendix TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.204 Germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.085 GTEX-S33H-1626-SM-4AD68 GTEx Tissue Sample Gene Expression Profiles 1.0 0.845944 PTCD3 Pathway Commons Protein-Protein Interactions 1.0 null NE-95-RP07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.225561 BL3509 (KDM4A) NURSA Protein Complexes 1.0 null JC-06-ED36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.377349 AKAP9 Pathway Commons Protein-Protein Interactions 1.0 null Rarg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 49.2657 extracellular region part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.663342 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tuberomammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02371 CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null RC-21-IF98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.427109 CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NE-94-VE83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.487826 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.978631 H3K4me1_CD4 Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-R55C-0626-SM-2TF4Q GTEx Tissue Sample Gene Expression Profiles 1.0 0.85814 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCN1A Pathway Commons Protein-Protein Interactions 1.0 null QE-93-PG25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.309158 HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.07248 TELO2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.8273 GTEX-XOTO-0826-SM-4B65O GTEx Tissue Sample Gene Expression Profiles 1.0 0.887661 GSE182680,GSE182683_5_v_2_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0011-R11A-SM-3DB7N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20905 SZ in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.846391 ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Ventromedial hypothalamic nucleus, central part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17728 posterior part of anterior hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.7256 HF-91-IU60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.16604 TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S33H-1226-SM-4AD69 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0547 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210476_11_v_4_rutaecarpine_human RummaGEO Drug Perturbation Signatures -1.0 null cellular phenotype MPO Gene-Phenotype Associations 1.0 null Supramammillary nucleus, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19701 TE-10 COSMIC Cell Line Gene CNV Profiles 1.0 2.30944 UB-21-MV06_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.21047 Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-E1-A7YL-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.484 primary motor cortex (area M1, area 4)_24 pcw_M_12288 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12062 Thymus Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.13748 GTEX-XUW1-1026-SM-4BONY GTEx Tissue Sample Gene Expression Profiles 1.0 1.89258 GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61351 RAD21_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ESRRB-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null orbital frontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.71645 NHE3_Deficiency_GDS3323_599_mouse_Colon GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null periventricular stratum of RtC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3126 ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.50879 HCT15 DepMap CRISPR Gene Dependency 1.0 2.53572 GTEX-S4Q7-1526-SM-3K2AG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13115 GSE221327_5_v_2_clpp_human RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13128 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DX-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CB-24-FA25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.347653 HCC1569 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.6549 Lingula (I), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.50138 Perturb_7216_KD_EZH2_SRP321650 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Rheaume et al.Nat Commun.18_Retina_Mouse CellMarker Gene-Cell Type Associations 1.0 null FLVCR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66202 GSE118077_7_v_2_sprr5_human RummaGEO Gene Perturbation Signatures -1.0 null rna 3'-end processing GO Biological Process Annotations 2015 1.0 null GOLGA4 Pathway Commons Protein-Protein Interactions 1.0 null SRF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PEA1 DepMap CRISPR Gene Dependency 1.0 9.53601 POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.94378 IMPDH1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11356 TEX10 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-0226-SM-32PLQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.36832 GTEX-Q2AG-1126-SM-48U1P GTEx Tissue Sample Gene Expression Profiles 1.0 0.963607 RRP12 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-WFON-0326-SM-3GIKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1686 GSE215086_5_v_7_batf_human RummaGEO Gene Perturbation Signatures 1.0 null Lassa Fever Virus_8hr_24069471_GSE41300 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.70099 GSE126463_6_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null lateral ganglionic eminence_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.47539 H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MZ in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14926 temporal muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30482 paclitaxel_homo sapiens_gpl570_gse11552 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null RPS11 Pathway Commons Protein-Protein Interactions 1.0 null central gray of the pons, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.999273 GTEX-P4QT-1626-SM-2S1NP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71521 RPL7 Pathway Commons Protein-Protein Interactions 1.0 null STAT6 MotifMap Predicted Transcription Factor Targets 1.0 null mrna 3'-end processing GO Biological Process Annotations 2015 1.0 null CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null In situ melanoma of skin_Epidermis_GSE4587 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.12571 GTEX-WY7C-2526-SM-3NB2N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36209 H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.897146 GTEX-R55D-0626-SM-3GAD5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.98035 SNU1544 DepMap CRISPR Gene Dependency 1.0 2.2732 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null LS-411N COSMIC Cell Line Gene Mutation Profiles 1.0 null Arid3b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.1164 GSE178267_2_v_4_vemurafenib_human RummaGEO Drug Perturbation Signatures 1.0 null Urinary system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.22 GSE158834_7_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_Caco-2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-1626-SM-3DB8N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00425 dorsal tuberomammillary nucleus, intermediate part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.12425 EFNB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45684 MED23 Pathway Commons Protein-Protein Interactions 1.0 null HCC202 CCLE Cell Line Gene Expression Profiles -1.0 -2.15041 H3K4me1_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null CTCF_GM12868_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DC-43-KF54_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.364651 GSE126463_4_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cerebellar ataxia type 47 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.061 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51H-06A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Uterine Cervical Neoplasms CTD Gene-Disease Associations 1.0 1.05828 HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.86138 Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.121 H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null A388 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.71209 GSE158834_7_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null MDA-MB-435 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.866 Kidney cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.15 H3K23me2_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE147240_3_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null Oculopharyngeal muscular dystrophy DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.88 MXI1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OB-65-AI50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.499467 ZC3H11A ENCODE Transcription Factor Targets 1.0 null H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE77108_3_v_1_saha_human RummaGEO Drug Perturbation Signatures 1.0 null UFL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09572 CTCFL ENCODE Transcription Factor Targets 1.0 null RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FA-36-VA24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.1707 Eukaryotic translation initiation factor 3 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.762 MRPS15 Pathway Commons Protein-Protein Interactions 1.0 null MDA-MB-175-VII COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-XYKS-0526-SM-4BRW2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16534 thymus GeneRIF Biological Term Annotations 1.0 null CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null retromammillary area, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26741 PREPL Pathway Commons Protein-Protein Interactions 1.0 null GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -2.96316 GTEX-TSE9-0011-R9A-SM-3DB7Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91172 primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.13999 GSE185519_1_v_7_gilteritinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE178340_1_v_2_carfilzomib_human RummaGEO Drug Perturbation Signatures -1.0 null K562_Rigosertib_100nM_24h Sci-Plex Drug Perturbation Signatures -1.0 -0.0140895 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-1126-SM-3P5ZR GTEx Tissue Sample Gene Expression Profiles 1.0 1.00838 H3K4me1_Brain Mid Frontal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null RPS24 Pathway Commons Protein-Protein Interactions 1.0 null GSE114992,GSE114993_7_v_5_irf5_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE158834_2_v_9_palm_human RummaGEO Gene Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z2-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU72-0126-SM-2TF6Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.85926 Renal carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.198 CSB-26484114-CHIP-SEQ-FIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-MP-A4T7-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE160817_3_v_9_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null Intestinal cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.414 BL6566 (KNTC1) NURSA Protein Complexes 1.0 null PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null Adipose - Visceral (Omentum) GTEx Tissue Gene Expression Profiles 2023 1.0 1.61368 GSE127790_13_v_2_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.08579 GTEX-OHPK-0326-SM-2HMJO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.949824 skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.56189 PMC12069319-Table1.xlsx-OCAB_WT_BirA-Gene_Symbol_POU2AF1 Rummagene Transcription Factor Associations 2026 1.0 null GSE186647,GSE217288_11_v_7_hnrnpc_human RummaGEO Gene Perturbation Signatures 1.0 null H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V955-0326-SM-4JBGV GTEx Tissue Sample Gene Expression Profiles 1.0 1.22243 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Nucleus of the lateral olfactory tract, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.76659 Dorsomedial nucleus of the hypothalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.54535 GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.75998 PBRM1 Pathway Commons Protein-Protein Interactions 1.0 null BT474 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 NCIH508 CCLE Cell Line Gene Expression Profiles 1.0 1.54996 abnormal ovarian follicle number MPO Gene-Phenotype Associations 1.0 null inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.27307 ACTB Pathway Commons Protein-Protein Interactions 1.0 null Fusome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.91 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6SW-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE250089_0_v_3_epcam_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null A549_JNJ-7706621_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0122865 red nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.03272 RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.69525 GSE247764_4_v_2_nell2_mouse RummaGEO Gene Perturbation Signatures -1.0 null NR3C1-27076634-BEAS2B-HUMAN-LUNG-INFLAMMATION ChEA Transcription Factor Targets 2022 1.0 null Eukaryotic translation initiation factor 2B complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.108 H3K79me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PBX3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null tail of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.11455 GTEX-P4QS-1026-SM-3NMCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.08201 NAT10 Pathway Commons Protein-Protein Interactions 1.0 null PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE123638,GSE123639_0_v_1_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null caudal (posterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05 limitans nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.32469 Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DI-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null heart GTEx Tissue Gene Expression Profiles -1.0 -1.09913 Morning person GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.43979 GSE60217_1_v_9_inosine_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TD-69-UA90_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.330779 Cytoplasmic stress granule COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 GTEX-TML8-0526-SM-32QOQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.02027 JUND_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZN-1426-SM-3DB87 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13741 GTEX-XPT6-2026-SM-4B64V GTEx Tissue Sample Gene Expression Profiles -1.0 -2.26442 GTEX-QEL4-1326-SM-447AD GTEx Tissue Sample Gene Expression Profiles 1.0 1.02819 WDR18 Pathway Commons Protein-Protein Interactions 1.0 null KYSE-520 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.993012 Lung squamous cell carcinoma_LUSC_TCGA-58-8388-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TEAD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NR-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary motor cortex (area M1, area 4)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.58348 HCC2218 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.82301 Lateral visual area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47861 CTCF_GM20000_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XV7Q-2926-SM-4BRUL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.942297 DMS79 CCLE Cell Line Gene CNV Profiles -1.0 -1.78533 Uterine Carcinosarcoma_UCS_TCGA-NF-A4WU-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null GSE221101_1_v_0_hopx_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WEY5-0226-SM-3GIKN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.975246 EFM-192A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.47786 POLR2AphosphoS2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16712 MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.90815 mantle zone of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45245 GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997784 NDUFA9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.66781 GTEX-U8T8-2326-SM-3DB96 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14926 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JV-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12673788-12967_2025_7484_MOESM5_ESM.xlsx-OCT4_cor_p_0_4-gene_id_POU5F1 Rummagene Transcription Factor Associations 2026 1.0 null YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6678_KO_PMVK_SRP255872 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.30402 lymphnode_4a HPA Tissue Sample Gene Expression Profiles 1.0 0.839827 FOXM1-25889361-OE33-AND-U2OS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CTCF_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE111247_2_v_7_temozolomide_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H1373 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.57737 GTEX-RNOR-1426-SM-48FDJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.19429 intermediate stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5938 POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_8843_KD_PPARGC1B_SRP254908 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-S341-0226-SM-2XCAX GTEx Tissue Sample Gene Expression Profiles 1.0 1.03543 H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nerve - Tibial GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.64692 hsa-miR-3918 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 H4K91ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HB-06-WU12_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.667902 GSE242555_1_v_0_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null Renal clear cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.832 RRBP1 Pathway Commons Protein-Protein Interactions 1.0 null WDR62 Pathway Commons Protein-Protein Interactions 1.0 null AB-71-CI37_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.310493 caudal interpeduncular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0931 SRF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE152441,GSE152442_1_v_5_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.220777 GSE169152_5_v_7_ibrutinib_human RummaGEO Drug Perturbation Signatures 1.0 null FOXA1_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF-18555785-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PK59 CCLE Cell Line Gene Expression Profiles 1.0 1.97488 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.60834 CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-93-A4JO-01A-21R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC202 CCLE Cell Line Gene CNV Profiles -1.0 -1.60467 H3K4me3_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null JHUEM7 DepMap CRISPR Gene Dependency 1.0 2.50965 Stomach cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.054 Midgut epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.647 Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01373 ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GE-98-ZI68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.210347 artery disease GWASdb SNP-Disease Associations 1.0 0.178784 LAD1 Pathway Commons Protein-Protein Interactions 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GSE182680,GSE182683_5_v_8_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-SE5C-0626-SM-2XCDV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02243 CCAR1 Pathway Commons Protein-Protein Interactions 1.0 null NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.932898 GSE81796_0_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null Nucleus of the lateral olfactory tract, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.99746 PF-59-CY33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.206704 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null LYAR Pathway Commons Protein-Protein Interactions 1.0 null TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of foreskin _hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE227127_1_v_0_diclofenac_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null S0-EE-YEKU_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.250039 CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UJMC-0526-SM-3GAE3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.958804 H3K36me3_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.73092 Lung squamous cell carcinoma_LUSC_TCGA-98-A53B-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.67899 POU2F2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EFM192A CCLE Cell Line Gene Expression Profiles -1.0 -1.86547 PMC12824661-BLOOD_BLD-2024-027020-mmc6.xls-Table_S14-HES4_Up_HES4 Rummagene Transcription Factor Associations 2026 1.0 null nitrogen compound metabolic process GO Biological Process Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-69-8255-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF15 Pathway Commons Protein-Protein Interactions 1.0 null abnormal cumulus expansion MPO Gene-Phenotype Associations 1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null facial motor nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.864978 GSE135312_1_v_2_bmpr2_human RummaGEO Gene Perturbation Signatures 1.0 null CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null disease GWASdb SNP-Disease Associations 1.0 0.034556 Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZEB1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Right_Ventricle Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.946265 Lung squamous cell carcinoma_LUSC_TCGA-NK-A5CT-01A-31R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null External ectoderm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.77 TUHR14TKB DepMap CRISPR Gene Dependency 1.0 2.44709 DF-00-DK69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.43737 RBBP8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08229 CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE133329_2_v_3_trim28_human RummaGEO Gene Perturbation Signatures -1.0 null NCI-H2106 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.37872 core of P-DMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.72407 EIF3E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.92923 GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95974 GTEX-WRHK-1626-SM-3MJFH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06041 CA-48-SW47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.243235 GSE171837_1_v_2_bortezomib_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_GM12870_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW780 CCLE Cell Line Gene Expression Profiles 1.0 2.43441 FD-91-OK66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.739564 GSE122101,GSE122103_0_v_4_ssu72_mouse RummaGEO Gene Perturbation Signatures 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.846 PANC 05.04 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.869729 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HK-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ALKBH8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.21763 amygdaloid complex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.28101 POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.24475 ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCI-LY7 COSMIC Cell Line Gene Mutation Profiles 1.0 null putamen, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.834884 SW962 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.36227 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.74441