association dataset threshold value standardized value thyroid GTEx Tissue Gene Expression Profiles 1.0 0.934737 NERF2-26677805-CHIP-SEQ-MACROPHAGESS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 Primary somatosensory area, lower limb, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05052 GSE213588_8_v_12_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null superficial stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.38853 BF-97-LS55_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 4.4143 GTEX-UPK5-0426-SM-3GAEK GTEx Tissue Sample Gene Expression Profiles 1.0 1.10944 GTEX-OIZH-1626-SM-2HMKI GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892963 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RNF2 ENCODE Transcription Factor Targets 1.0 null PMC6932815-ppat.1007634.s011.xlsx-ST1_DGE_ELF1_lfc2_fdr05_interse-external_gene_name_ELF1 Rummagene Transcription Factor Associations 2026 1.0 null ganglion TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-OHPL-0126-SM-2HMJ7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.80133 MGE-Lateral region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13094 r2 part of the ventral parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48953 overnutrition GWASdb SNP-Disease Associations 1.0 0.42272 SCC-25 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.67945 Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217405_0_v_1_osimertinib_mouse RummaGEO Drug Perturbation Signatures 1.0 null microtubule associated complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.323825 Gastrointestinal system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.026 ANKRD13A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2968 hsa-miR-4429 TargetScan Predicted Conserved microRNA Targets 1.0 0.257113 PCI-15A COSMIC Cell Line Gene CNV Profiles -1.0 -3.61078 PANC 08.13 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.05818 GTEX-XV7Q-1826-SM-4BRUV GTEx Tissue Sample Gene Expression Profiles 1.0 1.04501 YA-92-YO01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.15988 Tight junction COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FU-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null pontobulbar body Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.0815 GSE199543,GSE239447_0_v_4_ezh2_human RummaGEO Gene Perturbation Signatures 1.0 null KE-73-XV62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.08178 AB-64-ZX70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.268869 Subapical complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.158 Dmrt1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.1619 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE222758_0_v_3_clofazimine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MAZ JASPAR Predicted Human Transcription Factor Targets 2025 1.0 71.3911 H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TE4_OESOPHAGUS CCLE Cell Line Proteomics 1.0 2.05031 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cell-cell junction organization Reactome Pathways 2014 1.0 null hsa-miR-548l TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06263 Lung squamous cell carcinoma_LUSC_TCGA-56-8624-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EGR4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 104.853 Posterior parietal association areas, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54115 GSE216147_0_v_3_rbm20_mouse RummaGEO Gene Perturbation Signatures 1.0 null AD-27-JS45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215 GTEX-XOT4-0626-SM-4B66L GTEx Tissue Sample Gene Expression Profiles 1.0 1.08823 hsa-miR-548ae TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 PMC7518891-elife-58374-supp1.xlsm-Common_in_all_3_datasets_0_585-SOX11_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.05927 GSE164505,GSE164506_3_v_2_indisulam_human RummaGEO Drug Perturbation Signatures 1.0 null periventricular stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19168 NA-30-HS87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 3.60679 H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE120370_4_v_1_thrombin_mouse RummaGEO Drug Perturbation Signatures -1.0 null DB-21-FY75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.356662 DC-43-KF54_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.23164 GSE158456_2_v_3_furin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE184892_0_v_3_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-3921 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GSE127790_4_v_3_zcchc8_mouse RummaGEO Gene Perturbation Signatures 1.0 null CB-16-SY72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.05118 hsa-miR-3667-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.626 hsa-miR-4655-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 CF-24-KQ98_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.847186 CHD2 ENCODE Transcription Factor Targets 1.0 null RT112 CCLE Cell Line Gene Expression Profiles 1.0 1.52364 AB-71-CI37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.38295 pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12951 fusiform gyrus, right, bank of the its Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.37718 primary motor cortex (area M1, area 4)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.936942 GTEX-XAJ8-0826-SM-47JY6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37358 RAB3A_Mutation - D77G point mutation_GDS2482_702_mouse_Cortex GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.30604 GTEX-T2IS-0826-SM-4DM6L GTEx Tissue Sample Gene Expression Profiles 1.0 0.88309 GSE99187_1_v_0_gemcitabine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.2104 H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R45C-0006-SM-3GAD6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.99599 CB-32-EI69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.560171 Perturb_14596_OE_UQCRC1_SRP177975 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.31891 GTEX-QDVN-2026-SM-3GAEP GTEx Tissue Sample Gene Expression Profiles 1.0 1.03127 GTEX-OOBK-0126-SM-2YUND GTEx Tissue Sample Gene Expression Profiles 1.0 0.951866 GSE193351_1_v_0_ruxolitinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE125219,GSE125221_4_v_0_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null TRP63-18441228-KERATINOCYTES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04431 GSE119498_0_v_5_setd5_mouse RummaGEO Gene Perturbation Signatures -1.0 null MBD3-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO ChEA Transcription Factor Targets 2022 1.0 null inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.893866 GTEX-S4P3-0006-SM-3K2AW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57417 SR-786 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.924192 GTEX-QVJO-0006-SM-2S1RC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45408 SNU-387 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.851545 H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE181959_3_v_2_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null ACOT9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21638 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZE-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FC-20-EQ58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.328046 ChIP_MTF2_20144788 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE143830_0_v_1_trex1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BD-96-HO33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.09842 GSE223893_11_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kinociliary basal body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.596 GTEX-WRHU-0006-SM-3MJF6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3022 GTEX-O5YW-0006-SM-3LK6E GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93773 POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE242049_1_v_0_txndc5_mouse RummaGEO Gene Perturbation Signatures -1.0 null ID-70-SM63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.265865 ovary HPA Tissue Protein Expression Profiles 1.0 0.891168 Peroxisomal importomer complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.732 tight junction GO Cellular Component Annotations 2015 1.0 null GB-73-QS80_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.967727 AF-83-BX08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.365368 layer 4 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45956 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 Somatosensory areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56392 Foxj2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.8596 GTEX-R3RS-0005-SM-3GAEH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67957 superficial stratum of PCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91233 mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null HC-74-HM63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.36512 GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59271 CD79B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27664 hsa-miR-655 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE112860_3_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null BB-77-QQ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.522906 GSE135030_3_v_0_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GSE202434,GSE202438_3_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null SK-MEL-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.22985 Respiratory system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.193 GTEX-QVUS-0626-SM-447CC GTEx Tissue Sample Gene Expression Profiles 1.0 0.876247 GTEX-X62O-0005-SM-46MV1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09134 GSE219274,GSE219276_3_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE138001_0_v_3_rorb_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RAD21_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE181966_0_v_3_has2_mouse RummaGEO Gene Perturbation Signatures -1.0 null KA-81-AG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.596071 ED-02-CL76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.360768 Transforming growth factor beta activated kinase 1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.823 ARHGEF2 Pathway Commons Protein-Protein Interactions 1.0 null Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.129 GSE201217_4_v_6_usf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CA-42-YI34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.51349 GSE135514_8_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null YWHAH Hub Proteins Protein-Protein Interactions 1.0 null H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ6-1426-SM-2S1OQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.51398 GSE118816_2_v_3_myo1c_human RummaGEO Gene Perturbation Signatures 1.0 null GSE210885_5_v_4_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null Patau syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.111 hsa-miR-545 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 intermediate part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61981 GTEX-WK11-2726-SM-3NMAQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.2295 Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-4104-01A-02R-1351-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE133516_5_v_6_kat7_human RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WHSB-1326-SM-3LK6W GTEx Tissue Sample Gene Expression Profiles 1.0 1.90874 ME-31-RM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.33826 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MRPS24 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03837 NFXL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00157 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.830681 Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE166783_1_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null GSE134191_6_v_1_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null periventricular stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.48163 hsa-miR-4277 TargetScan Predicted Conserved microRNA Targets 1.0 0.045136 SARS-CoV MA15_Day7_None_GSE49263 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.80664 Intraciliary transport particle B COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.672 KPNA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03716 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of skin of abdomen_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-94-8035-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.946476 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NN-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H4K20me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.999438 REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CardiacMyocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.41577 KAP1-27257070-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.55599 GSE244710_1_v_0_srsf1_human RummaGEO Gene Perturbation Signatures -1.0 null angular gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08068 INSM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 84.7083 H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null layer 1 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.34048 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A954-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE229914_1_v_3_keap1_human RummaGEO Gene Perturbation Signatures 1.0 null vestibular nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.8414 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.16907 Acute Myeloid Leukemia_LAML_TCGA-AB-2849-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U3ZH-0005-SM-3DB72 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25982 GTEX-NFK9-0226-SM-2HMKQ GTEx Tissue Sample Gene Expression Profiles 1.0 2.52352 TBX5 ChEA Transcription Factor Targets 1.0 null CTCF_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4252 TargetScan Predicted Conserved microRNA Targets 1.0 0.670641 CTCF_fibroblast of gingiva_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular part LOCATE Curated Protein Localization Annotations 1.0 null GSE231648_1_v_2_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_8633_KO_Sh3gl1/Sh3gl2_SRP082219 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 7.95991 FOXA2 ENCODE Transcription Factor Targets 1.0 null HC-01-FD24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.516647 GSE153871_4_v_2_cytarabine_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_10031_KD_MSI2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.24009 GTEX-VJWN-0126-SM-3GIK7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20405 H3K4me1_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mRNA_NR0B1_19530134 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2724-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mRNA_DLX3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null DTD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03854 GTEX-S7SE-0126-SM-2XCD5 GTEx Tissue Sample Gene Expression Profiles 1.0 2.09262 FA-36-VA24_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.746127 GSE154464_1_v_3_cdk6_mouse RummaGEO Gene Perturbation Signatures -1.0 null AA-86-YY62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.561324 L33 DepMap CRISPR Gene Dependency 1.0 4.07175 EF-01-LB20_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.422788 KLF14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 184.147 GSE142210_3_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null superficial stratum of PHyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14628 posteroventral (inferior) parietal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.914037 CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZFP90 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17084 AE-14-NN26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.600922 parietal cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91233 GSE216273,GSE216292_0_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null ZFP281-27345836-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Genetic Predisposition to Disease HuGE Navigator Gene-Phenotype Associations 1.0 null H2AFZ_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pax7 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 39.2988 GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.861844 GSE139016_3_v_2_disulfiram_human RummaGEO Drug Perturbation Signatures -1.0 null KARPAS-1106P Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.15142 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5095-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AA-49-BD04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.598409 AA-88-PJ86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.394258 Brain Lower Grade Glioma_LGG_TCGA-DH-A7UU-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r6 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.0882 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4981-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null paracentral lobule, posterior part, right, bank of cingulate sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.22391 PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S9-ZNF384_SpecDMCs-Unnamed_3_ZNF384 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null SC-72-YW56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.213377 skin_6a HPA Tissue Sample Gene Expression Profiles 1.0 1.67092 NCIH522 CCLE Cell Line Gene Expression Profiles 1.0 1.74877 GSE202434,GSE202438_9_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.48487 lateropallial prepiriform area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20971 Integumentary system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.961 COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15196 HCC1187 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.00089 GTEX-X5EB-0726-SM-46MVR GTEx Tissue Sample Gene Expression Profiles 1.0 0.894352 59M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.05951 HB-06-WU12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.996446 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.12689 apical junction complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GSE122215,GSE122217_0_v_4_peg10_mouse RummaGEO Gene Perturbation Signatures -1.0 null FA-63-WI26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248647 17875932-TableS4 GeneSigDB Published Gene Signatures 1.0 null superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.876052 PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Significant_DE_genes_in_AKT1_vs_KLF4_meningiomas_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null cytoplasmic part GO Cellular Component Annotations 2015 1.0 null non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.059445 MI-773 DeepCoverMOA Drug Mechanisms of Action 1.0 1.39 Perturb_4900_KD_NANOG_SRP158631 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.5739 JIMT-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12009 Cell-Cell communication Reactome Pathways 2024 1.0 null GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00863 Brain Lower Grade Glioma_LGG_TCGA-DU-8165-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HT-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-VV-A86M-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.944553 Inflammation CTD Gene-Disease Associations 1.0 1.45009 MTF2 ChEA Transcription Factor Targets 1.0 null QE-79-XO29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.08316 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FW-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE242290_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null FD-72-CE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232637 Perturb_2779_OE_ACF7_SRP109301 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -13.394 principal sensory nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1274 CDH5 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51263 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6021-01A-11R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Foxo3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.6077 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CR-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_9841_KD_KDM6A_SRP254623 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.5369 GSE261563_9_v_1_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null BB-84-DG64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.523579 central part of CEl Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02129 CD33+_Myeloid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.939404 hsa-miR-548x TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Brain Lower Grade Glioma_LGG_TCGA-DU-6404-02A-21R-A36H-07,TCGA-DU-6404-02B-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FE-82-WB22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.920369 GSE93309_1_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SB-269970 DeepCoverMOA Drug Mechanisms of Action 1.0 0.46 bonemarrow_5a HPA Tissue Sample Gene Expression Profiles -1.0 -1.78253 928 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.874201 Lung squamous cell carcinoma_LUSC_TCGA-58-A46N-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WY7C-0006-SM-3NB3L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2465 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05824 Cell cortex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.35788 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null QTRT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13236 H3K4me1_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null mantle zone of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20971 superficial stratum of r8BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58342 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HV-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SW 900 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03091 Perturb_6787_KD_KRAS_ERP122260 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.6042 GAB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34119 H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Hmgn1_KO_GDS5010_406_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null cell-cell junction GO Cellular Component Annotations 2025 1.0 null PAR polarity complex COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 BC-00-YH62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.439502 SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.2125 QE-00-EB96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.228833 NCI-H1105 COSMIC Cell Line Gene Mutation Profiles 1.0 null HSPA4 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_16594_KO_Xbp1_SRP057879 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.30924 Aorta Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.949415 Tailbud stage TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.532 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of pulmonary artery_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE153871_5_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures 1.0 null AB-71-CI37_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.270282 GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0484 GTEX-XMD3-0006-SM-4AT5X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.961491 GTEX-U3ZN-0006-SM-3DB7Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.842744 haloperidol_mus musculus_gpl339_gds2531 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE96641_1_v_4_esrp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OXRL-1826-SM-2YUMV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.887871 FA-16-HR75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.319985 GTEX-U8T8-1426-SM-3DB9H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.975173 ETV2-25802403-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC9019027-42003_2022_3332_MOESM3_ESM.xls-Table_S1_HUVEC_MED23-KD_DEGs-gene_id_AR Rummagene Transcription Factor Associations 2026 1.0 null AD-16-HL96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.86334 GSE122215,GSE122217_0_v_1_peg10_mouse RummaGEO Gene Perturbation Signatures -1.0 null MAX ENCODE Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A82C-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RASSF8 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null HC 030031 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.29 HCA-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null RH30 CCLE Cell Line Gene Expression Profiles 1.0 2.18355 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N6-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KA-29-AB08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.574335 serine/threonine protein kinase complex GO Cellular Component Annotations 2025 1.0 null HGC27 CCLE Cell Line Gene Expression Profiles -1.0 -2.24609 CTCF_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DA-83-IZ87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.279665 KATO III Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.853169 GSE142210_11_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE206729_5_v_1_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null PMC10305740-pwac061_suppl_supplementary_table_s1.xlsx-FOXO3-knockout_bulk_RNA-seq-Differentially_expressed_genes_identified_in_bulk_RNA-seq_of_FOXO3-_-_vs_FOXO3_hMyotubes_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05378 PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-E16_vs_D1_1084_AR-DEGs-Symbol_AR Rummagene Transcription Factor Associations 2026 1.0 null thyroid_5d HPA Tissue Sample Gene Expression Profiles 1.0 1.22388 Perturb_3325_KO_Tkt_SRP364774 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.004 liminal part of r2 alar plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55269 ventral tuberomammillary nucleus, superficial part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21785 SNU-638 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08717 GSE142210_9_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE178292_0_v_2_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null GSE206270_2_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1500 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14303 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV3-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 3 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21611 GTEX-XUYS-0126-SM-47JWZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.81742 AC-84-QG99_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.405517 anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.887541 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null IB-56-JN40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.312648 ZBTB33 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.66627 AC-83-LN99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.458503 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A4S6-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE137954_4_v_2_smyd3_mouse RummaGEO Gene Perturbation Signatures -1.0 null bonemarrow_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.57606 TFAP2C-20629094-MCF-7-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A184-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Apical part of cell COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 APD668 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.38 Cerebral cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1787 YE-80-LN04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.223537 GTEX-SUCS-0326-SM-32PLL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852331 Edwards syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.508 GTEX-P4PQ-1626-SM-2HMKK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.86714 Perturb_15559_KO_SLFN11_SRP327912 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.68906 GSE135514_2_v_0_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-548a-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41P-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dicyclohexylamine DeepCoverMOA Drug Mechanisms of Action -1.0 -0.34 nutrition disease GWASdb SNP-Disease Associations 1.0 0.353162 ANKEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0424 ZNF343 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 80.5212 AA-48-XT80_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.488277 superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03449 H3K9ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null DC-51-WE27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.312605 GSE180813,GSE180815_1_v_0_mettl3_mouse RummaGEO Gene Perturbation Signatures 1.0 null SARS-CoV_12Hour_20090954_GSE17400 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.1876 AD-06-OB47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.473694 Prospore contractile ring COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.52 UBTF_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null QB-88-PG52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.684292 GTEX-WK11-0006-SM-3NB3J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12341 GSE224599_0_v_1_tfcp2_human RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7051-11A-02R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Schwartz-Jampel syndrome 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.157 H3K4me1_Adult Liver Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MZ in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.850729 GSE206516,GSE206518_3_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null nucleus of the diagonal band, left, horizontal division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.825157 Perturb_6788_KD_NUDT21_ERP122260 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.54324 FA-80-DR66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.12476 PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Gene_Name_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null WC-09-GD62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.1301 GTEX-PX3G-0006-SM-33HBQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11268 anterior hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.857677 GTEX-WCDI-0005-SM-3NB2M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73755 GTEX-RTLS-0006-SM-2TF58 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41578 PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1 Rummagene Transcription Factor Associations 2026 1.0 null arcuate nucleus of medulla, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0803 PMC9601604-NIHMS1841143-supplement-SuppTable-3.xlsx-shared_upregulated-Genes_upregulated_in_the_absence_of_FOXO3_in_GSCs_and_aged_NSCs_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null AF-11-IL39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.405562 GSE206270_2_v_0_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4349-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WXYG-2326-SM-4E3I6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.48173 Adherens junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.43 GSE193402_0_v_3_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null esophagus_5b HPA Tissue Sample Gene Expression Profiles 1.0 1.00461 GATA3 ENCODE Transcription Factor Targets 1.0 null GSE216538_1_v_6_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Gene_Name_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UJHI-0006-SM-3DB8H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17049 Septate junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.606 Pavement epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.211 dorsal motor nucleus of the vagus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.824949 ventrolateral prefrontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.09382 GTEX-RU72-1326-SM-2TF6T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.929229 smooth muscle HPA Tissue Protein Expression Profiles 1.0 0.891168 plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 TBX5-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TFAP2B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 181.442 Angelman syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.065 Nr2e1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 38.2672 Central nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.009 PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE151689_0_v_1_panobinostat_mouse RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-548b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-U8T8-0126-SM-3DB94 GTEx Tissue Sample Gene Expression Profiles 1.0 1.77589 GTEX-X4XX-0926-SM-46MV7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.831339 BF-19-KU00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.981572 orbital frontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.855396 Hmga1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.0094 CTCF_skin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null disease GWASdb SNP-Disease Associations 1.0 0.026955 BHY cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.757 H3K27ac_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Schizoid personality disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.17673 IZ in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.13968 microtubule organizing center COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.295119 GSE147366_1_v_4_med13_human RummaGEO Gene Perturbation Signatures 1.0 null paraterminal gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.975157 NCIH146 CCLE Cell Line Gene CNV Profiles 1.0 2.30421 POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-YH-A8SY-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Atosiban DeepCoverMOA Drug Mechanisms of Action -1.0 -0.29 WDR91 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50555 GSE188870,GSE188871_4_v_3_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null E2F6 ENCODE Transcription Factor Targets 1.0 null MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.79675 H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.064 CTCF_GM12868_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PC-18-VX23_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.295637 NFIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.3139 GSE163297_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE142684_3_v_6_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_14670_KO_Lkb1_ERP006813 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 18.3468 GSE247862,GSE247863_0_v_5_eomes_mouse RummaGEO Gene Perturbation Signatures -1.0 null OSBPL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14099 PARD6A Pathway Commons Protein-Protein Interactions 1.0 null AB-84-PK04_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.200488 primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20375 Pancreatic_Islets Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.07554 GTEX-RNOR-0005-SM-2TF4Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19079 GSE151782_4_v_7_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GC-04-UF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.32725 XD-44-FJ34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.24901 TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-X638-0126-SM-47JZ8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17977 GTEX-WYJK-0526-SM-3NM8Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.15033 Reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.116 QA-34-PH05_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.242163 GSE184892_4_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-548j TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GSE213588_9_v_3_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.2282 BC-62-RZ55_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.235385 BE-04-AN21_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.20438 POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FP-01A-21R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CDC40 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.26078 KA-75-LP02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.723624 TF-29-QU48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.01744 Rectum adenocarcinoma_READ_TCGA-AF-2689-11A-01R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventromedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10141 Liver hepatocellular carcinoma_LIHC_TCGA-CC-5258-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ACVR1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.42976 Primary somatosensory area, lower limb, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.43246 H3K4me1_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K27ac_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null basomedial nucleus (accessory basal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.892135 CHD2_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE109140_2_v_3_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE151612_0_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null FF-28-ES17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.627027 Ovarian follicular epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.285 hsa-miR-548i TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 amygdalostriatal transition area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.03761 SP3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 168.846 GTEX-SIU8-0006-SM-2XCE5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20915 GSE142210_4_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_foreskin fibroblast_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SHROOM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21393 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2226 Type 2 diabetes mellitus_Hepatic Tissue_GSE2899 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.77068 skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -0.943514 Perturb_17033_KD_Nr3c1_SRP149816 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.14753 Carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.276 PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaDadj_vs_NC-Gene_ERG Rummagene Transcription Factor Associations 2026 1.0 null UCSD-242L Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.17198 H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AE-51-ZO26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.330265 GTEX-QLQW-1126-SM-2S1Q8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.956142 AOB, mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13804 RAD21 ENCODE Transcription Factor Targets 1.0 null OLIG2-23332759-OLIGODENDROCYTES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12874_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 93.7357 posterior paraventricular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1076 WDR89 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19429 IB-08-VY61_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.265012 magnocellular superficial hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14552 AA-87-EI21_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.340512 HC-92-HE59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 4.25156 GSE154069_2_v_4_satb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null mantle zone of r2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55269 GTEX-OXRP-0126-SM-3NB32 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2391 centrosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.336241 GTEX-O5YW-0126-SM-3LK6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.899252 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H2BK15ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-T8EM-1026-SM-3DB7M GTEx Tissue Sample Gene Expression Profiles 1.0 1.60661 ES5 DepMap CRISPR Gene Dependency 1.0 2.90803 H3K4me3_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.21513 superficial stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16053 H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE216274,GSE216292_4_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.10793 Bed nucleus of the accessory olfactory tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78816 SNU685_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 2.37066 AA-68-OJ16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.376118 TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null SUM149PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.707464 GSE110268_2_v_3_foxd1_human RummaGEO Gene Perturbation Signatures 1.0 null CTCF_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XYKS-2126-SM-4E3IB GTEx Tissue Sample Gene Expression Profiles 1.0 1.21629 BA-34-BQ43_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.304269 639V CCLE Cell Line Gene CNV Profiles -1.0 -1.5762 MDCK cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.366 NCIH2228 CCLE Cell Line Gene Expression Profiles -1.0 -2.16645 GSE206270_1_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6953-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.884534 AE-37-MC27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.206966 Apical cortex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.33 Motor nucleus of trigeminal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00503 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null 496100410_TCx_possible Alzheimer's disease_TBI_87_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.13791 GTEX-X3Y1-0006-SM-3P5ZG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36459 GTEX-SNOS-1526-SM-32PLW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08878 Perturb_15016_KO_MESP2_SRP153048 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.58616 GSE153137,GSE153140_2_v_1_mettl5_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-T2IS-1926-SM-4DM74 GTEx Tissue Sample Gene Expression Profiles 1.0 0.942719 mammillary area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37383 H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE135030_8_v_4_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S33H-0005-SM-2XCAL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73648 GSE118765_1_v_5_rreb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_fibroblast of lung_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE233679_14_v_15_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GATA1 ENCODE Transcription Factor Targets 1.0 null H3K27me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100522_PCx_dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.03679 GSE211931_2_v_3_ncoa4_mouse RummaGEO Gene Perturbation Signatures 1.0 null MELHO CCLE Cell Line Gene Expression Profiles 1.0 1.75556 estradiol_homo sapiens_gpl570_gds3283 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Perturb_11692_KD|OE_SF3A3|MYC_SRP253943 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 13.9936 GSE202434,GSE202438_4_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null NAT10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32096 H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of TPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27968 TIMM13 Pathway Commons Protein-Protein Interactions 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70P-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null C-33 A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.21967 CF-24-KQ98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.310187 ABHD15 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.86389 RBPMS CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35718 Perturb_10036_KD_PUM2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.59175 MARK2 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QESD-0006-SM-2I5G6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40709 GSE230744,GSE237803_0_v_3_hira_human RummaGEO Gene Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A87N-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_9888_KD_ESF1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.42455 GTEX-XXEK-2226-SM-4BRUM GTEx Tissue Sample Gene Expression Profiles 1.0 1.05352 SOX3-22085726-MUSCLE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hennekam syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.238 GSE228413_2_v_3_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE114284_1_v_5_irf1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-O5YV-0006-SM-2I5GX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22497 IA-76-ZU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.322169 Liver hepatocellular carcinoma_LIHC_TCGA-FV-A4ZQ-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_2_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null disease of anatomical entity GWASdb SNP-Disease Associations 1.0 0.026111 HCC15_LUNG CCLE Cell Line Proteomics 1.0 3.07745 AB-00-IL62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.259785 PMC10305740-pwac061_suppl_supplementary_table_s1.xlsx-FOXO3-knockout_bulk_RNA-seq-Unnamed_1_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null PRPF4_02_128 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59521 CTCF_pancreas_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FD-91-OK66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.83489 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4833-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE77108_0_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-548w TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 cytoplasm LOCATE Curated Protein Localization Annotations 1.0 null intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.048625 GTEX-VUSG-0006-SM-3GIK9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.91243 GTEX-R53T-0005-SM-3GADK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.984389 Perturb_2830_OE_RAF1_SRP064353 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.49466 GSE148066,GSE157787_5_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE231648_1_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE223893_2_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null AA-46-GL76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.294464 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NE-94-VE83_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.739004 superficial stratum of TSPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83103 PDZ domain InterPro Predicted Protein Domain Annotations 1.0 null Perturb_13394_KD_AHR_SRP154013 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.25182 H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE145215_2_v_1_krt13_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE128730_7_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_15984_KD_LINC00704_SRP221619 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.51016 NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.841156 GSE94011_0_v_3_pias3_mouse RummaGEO Gene Perturbation Signatures -1.0 null epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053784 AA-22-UI44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.538317 Perturb_1302_OE_ERG/MYC_SRP069177 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.88208 GSE68156_0_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE224742_0_v_1_slc1a5_human RummaGEO Gene Perturbation Signatures 1.0 null CCC5 DepMap CRISPR Gene Dependency 1.0 3.12206 Endocytosis KEGG Pathways 2026 1.0 null r8 part of inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.08512 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HG-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_cardiac mesoderm_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE76425_0_v_5_lenalidomide_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HINFP JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.7285 hsa-miR-4428 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 mcf-7 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.245491 NANOG-16518401-CHIP-PET-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE151119_3_v_1_hsf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null pterigoid muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22939 rostral paraventricular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28047 POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.22171 FARAGE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25163 r6 part of the basolateral reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.27733 LC-12-VN85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.708569 para-abducens nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.53559 GTEX-WY7C-2326-SM-3NB2U GTEx Tissue Sample Gene Expression Profiles 1.0 1.22273 Perturb_2827_OE_ERK1_SRP064353 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.79994 AE-07-IZ32_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.268583 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4223-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE65617_0_v_4_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE183041_1_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE239688_4_v_3_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE57871_6_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A42Z-01A-12R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZFX-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GSE221327_5_v_2_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null Fetal Brain Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.12399 GSE130383_1_v_0_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WFG8-2226-SM-3GIL9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.22314 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.18107 GTEX-R3RS-0126-SM-3GIJL GTEx Tissue Sample Gene Expression Profiles 1.0 1.76996 JHH7_LIVER CCLE Cell Line Proteomics 1.0 7.82817 GTEX-XUJ4-1826-SM-4BOOU GTEx Tissue Sample Gene Expression Profiles 1.0 0.931229 cell-cell junction organization GO Biological Process Annotations 2015 1.0 null PMC5630028-supp_gr.220533.117_Supplemental_File_S7.xlsx-TP53_core_genes-Unnamed_1_TP53 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.11584 RD-90-OY66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 3.82611 diethylstilbestrol_mus musculus_gpl6887_gse37969 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null JUND ENCODE Transcription Factor Targets 1.0 null Cell junction organization Reactome Pathways 2014 1.0 null H3K4me1_H1 Derived Mesenchymal Stem Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HCFC1 ENCODE Transcription Factor Targets 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2950-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Fetal Death CTD Gene-Disease Associations 1.0 1.18159 GSE122990,GSE123061_0_v_1_urod_mouse RummaGEO Gene Perturbation Signatures -1.0 null KCNH2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78414 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null GTEX-WQUQ-0426-SM-3MJFU GTEx Tissue Sample Gene Expression Profiles 1.0 1.73956 GD-82-CS38_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.485867 hsa-miR-3161 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 RPL10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16886 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055802 WC-59-RG09_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.387034 hsa-miR-1205 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A5KD-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Congenital nervous system abnormality DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.006 GC-04-UF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.23071 GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.929114 KLF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 154.967 excretory gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065787 dorsorostral division of MFC (area 32) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37993 occluding junction GO Cellular Component Annotations 2015 1.0 null LTV1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04293 r10 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04411 CTCF_brain microvascular endothelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLIS3_KO_GDS3812_500_mouse_Embryonic pancreas at E15.5 GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NCI-H1651 COSMIC Cell Line Gene CNV Profiles -1.0 -3.61078 H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE77108_8_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.785298 Lung adenocarcinoma_LUAD_TCGA-38-4630-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE199255,GSE199356_4_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-XQ3S-1426-SM-4BOPR GTEx Tissue Sample Gene Expression Profiles 1.0 1.60804 skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -1.3509 FB-66-UU47_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.52581 GBAS Pathway Commons Protein-Protein Interactions 1.0 null primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20851 AN3 CA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03811 GSE98898_8_v_1_hoxa1_human RummaGEO Gene Perturbation Signatures 1.0 null BD-66-QO48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.213737 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_39_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null A-CA-04-2009(H1N1)_Day3_22532695_GSE36328 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.63277 GTEX-T6MO-0006-SM-32QOU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45651 GSE171175,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_7287_KD_HNRNPG_SRP064870 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.59198 hsa-miR-4633-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 HEC265 DepMap CRISPR Gene Dependency 1.0 3.8743 C16orf54 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77216 AD-66-NV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203701 DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.0439 GTEX-RU1J-0006-SM-2TF6M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.842308 GSE94849_6_v_4_pinometostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WYVS-2126-SM-3NMA3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.79732 GSE234637_1_v_0_ikzf1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RNOR-0926-SM-2TF56 GTEx Tissue Sample Gene Expression Profiles 1.0 0.935288 GSE214583,GSE214585_1_v_0_steap1_human RummaGEO Gene Perturbation Signatures -1.0 null Embryonic structure TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A5QF-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU61 CCLE Cell Line Gene CNV Profiles -1.0 -1.47591 H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null STUB1 Pathway Commons Protein-Protein Interactions 1.0 null Medial septal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06008 EGR1 ENCODE Transcription Factor Targets 1.0 null ZFX ChEA Transcription Factor Targets 1.0 null Dopaminergic synapse COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.65 GTEX-PWCY-0005-SM-33HBP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09773 S0-EE-Y7IR_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.326578 POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1-26743006-CHIP-SEQ-LNCAP-ABL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NCIH2087 CCLE Cell Line Gene CNV Profiles -1.0 -2.74606 SUGT1 Pathway Commons Protein-Protein Interactions 1.0 null H3K27ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CD-35-BD44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.63507 BB-86-BE39_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.227457 MEWO CCLE Cell Line Gene Expression Profiles 1.0 1.58839 TP53 ChEA Transcription Factor Targets 1.0 null GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30984 RD-92-QT24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.538829 C1orf210 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2663 shell of SCH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.82995 QA-50-YO37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.27405 MERRF syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.312 SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-WHSB-1826-SM-3TW8M GTEx Tissue Sample Gene Expression Profiles -1.0 -0.852053 H3K27me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE200673,GSE200691_1_v_5_hmga2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-U4B1-0006-SM-3DB8E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22356 ZNF75D JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.8522 CTCF_GM19240_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15145 NRF2-20460467-MEF-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.05137 GTEX-OHPM-0126-SM-2YUN9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.959155 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GL-06A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EGFR_druginhibition_83_GSE27640 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.16157 Ventromedial hypothalamic nucleus, ventrolateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12429 HCC95 CCLE Cell Line Gene CNV Profiles -1.0 -2.15972 AD-18-XC14_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.441135 ventral part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08229 Anterolateral visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61248 CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.19379 PMC9314667-Table_1.xlsx-Regulons-TFAP2A_TFAP2A Rummagene Transcription Factor Associations 2026 1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null SP8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 89.5098 ACSF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.31004 Perturb_14091_OE_MIR372_SRP075051 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.02249 GB-57-XV52_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.688242 GSE223008_5_v_2_calhm6_mouse RummaGEO Gene Perturbation Signatures -1.0 null YA-78-MS95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.236568 GTEX-WH7G-2326-SM-3NMBC GTEx Tissue Sample Gene Expression Profiles 1.0 1.13091 Perturb_7267_OE_OspC3_SRP368098 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.934 SMC3 ENCODE Transcription Factor Targets 1.0 null DMS 53 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.73357 UA-39-TN76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248659 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16053 GTEX-X5EB-0006-SM-46MV5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54376 GSE158456_1_v_3_furin_mouse RummaGEO Drug Perturbation Signatures -1.0 null PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_6_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null SP9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 156.181 Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE224096_2_v_0_cocaine_human RummaGEO Drug Perturbation Signatures -1.0 null superficial stratum of TPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51762 GTEX-WFG7-2226-SM-3GIKP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23534 GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.45189 DA-35-DU85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.383642 HCC33 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.911523 GSE175787_4_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null ASIC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13218 GSE221327_5_v_0_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-S7SE-0005-SM-2XCEA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30212 CB-82-PL01_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.347108 mantle zone of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08192 PMC12209767-bcd-25-0099_supplementary_table_s2_suppst2.xlsx-C_DEGs_RNA-seq-Supplementary_table_S2C_List_of_differentially_expressed_genes_in_IGHUND_vs_IGH_GCB_MB2_DE_DLBCL_HGBCL-DH-BCL2_-BCL6_BCL6 Rummagene Transcription Factor Associations 2026 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CREB3L1_CREB3L1 Rummagene Transcription Factor Associations 2026 1.0 null OC-10-FB51_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.733117 H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.585774 EC-62-OE64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.747773 TB-06-VB30_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.279328 GSE195559_2_v_7_notch1_human RummaGEO Gene Perturbation Signatures -1.0 null AC-55-XA97_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.447809 H3K4me1_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_9975_KD_CKAP4_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.34993 KLF12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 197.764 MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11839389-PUL2-15-e70058-s003.xlsx-FLF_TBX4_mergeRNAseqChIPseq-symbol_TBX4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RN64-1026-SM-48FDX GTEx Tissue Sample Gene Expression Profiles 1.0 1.07707 hsa-miR-3942-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.404082 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210580_0_v_7_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null inferior temporal gyrus, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13617 inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.0764 GPR19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06786 dorsomedial hypothalamic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.850038 IZ in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1378 GTEX-SNMC-1226-SM-2XCFP GTEx Tissue Sample Gene Expression Profiles 1.0 1.63104 H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.851869 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4876-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6353-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE193351_1_v_3_ruxolitinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE173201_0_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OXRP-0926-SM-48TC1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.97372 H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null DA-27-BW20_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.07863 CC-93-RP38_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206095 CB-16-SY72_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.09145 tight junction COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null AB-09-EA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231444 AB-85-JR73_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.830011 TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.22629 YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.42374 PK-59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.43964 superficial stratum of FCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06983 PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_15_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-OOBJ-0006-SM-2I3F4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01959 EF-74-KW12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.832843 GSE213588_9_v_0_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2861 lateral part of MM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33264 WC-09-GD62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.46084 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE94849_1_v_0_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FO-11A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE234637_1_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9314667-Table_1.xlsx-Regulons-SOX10_SOX10 Rummagene Transcription Factor Associations 2026 1.0 null NUDC Pathway Commons Protein-Protein Interactions 1.0 null GTEX-X4XX-0126-SM-3NMC2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28136 Tuberomammillary nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76262 AC-75-CE67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.830605 esophagus_5c HPA Tissue Sample Gene Expression Profiles 1.0 1.08181 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5683-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE206729_3_v_1_trps1_human RummaGEO Gene Perturbation Signatures -1.0 null NB-80-IM48_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.331731 PARD6G CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22665 H3K27ac_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_10000_KD_CPSF6_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 11.4764 GTEX-U8XE-0926-SM-3DB8V GTEx Tissue Sample Gene Expression Profiles -1.0 -0.949201 GSE182179_5_v_3_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27749 small_intestine BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.82437 CTCF_GM12871_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01182 H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7PM-0006-SM-3NM8C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03327 Perturb_9998_KD_STIP1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.06808 HS695T CCLE Cell Line Gene CNV Profiles 1.0 1.44748 GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.928043 nucleus GO Cellular Component Annotations 2023 1.0 null ACAD10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27889 GSE168807_0_v_7_dnmt3a_mouse RummaGEO Gene Perturbation Signatures -1.0 null Hyperplasia CTD Gene-Disease Associations 1.0 1.14336 KDM4A ENCODE Transcription Factor Targets 1.0 null TUBG1 Pathway Commons Protein-Protein Interactions 1.0 null ERBB2_knockdown_235_GSE8373 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.84563 BICR 78 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.97022 H3K4me2_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HC-74-HM63_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.77487 Perturb_10666_OE_HSPB2_SRP288471 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.59898 Tight junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.782 AD-86-OB87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.379841 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE193177_1_v_3_st266_mouse RummaGEO Drug Perturbation Signatures -1.0 null NF-21-HQ00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.12866 NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03192 GSE191015_0_v_3_gsdmb_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_8067_KD_SNORD126_SRP337208 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.39278 AC-83-LN99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.204556 PD-70-VS77_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.407267 chr18_80217851_G_GA_b38 GTEx eQTL 2025 1.0 1.4596 CL14 CCLE Cell Line Gene CNV Profiles -1.0 -1.5111 FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YWHAE Pathway Commons Protein-Protein Interactions 1.0 null HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.837115 Perturb_717_KO_TET2_SRP200817 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 11.9739 FF-28-ES17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.23822 KP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.979749 OVK18 CCLE Cell Line Gene Expression Profiles 1.0 2.36071 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5452-01A-01R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.935784 Acne DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.961 H2AFZ_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.25543 PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.80643 Brain Lower Grade Glioma_LGG_TCGA-VV-A829-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S4Q7-1526-SM-3K2AG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826395 PMC10863267-12864_2024_10083_MOESM1_ESM.pdf-374-HMGA2_HMGA2 Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE129772_2_v_3_runx3_mouse RummaGEO Gene Perturbation Signatures 1.0 null superficial stratum of CCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3883 CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AC-30-XU83_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.708152 NF-21-HQ00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.584041 Lymphoma_burkitts(Daudi) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.853543 anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.902287 PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null oocyte BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.28147 GSE183316,GSE183317_4_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-U8XE-0005-SM-3DB8I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.70943 plicamycin_homo sapiens_gpl570_gse25127 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC8858874-NIHMS1764275-supplement-Supplemental_Table_2.xlsx-R1_SOX2_bound_genes_5000bp_6-9--Nearest_Ensembl_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null BL322 (MLH1) NURSA Protein Complexes 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5710-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03485 GSE183316,GSE183317_1_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-Q2AG-0005-SM-33HBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11649 GSE124471,GSE124488_1_v_0_lats1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_10002_KD_FTO_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.71117 dynactin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.895794 GSE233679_5_v_15_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null YWHAZ Pathway Commons Protein-Protein Interactions 1.0 null GTEX-SUCS-1926-SM-32PM3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28848 GSE119498_6_v_4_setd5_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.93983 GSE128730_4_v_2_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null QE-18-WG07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.293571 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null VEZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.9651 Perturb_15392_KD_CHD6_SRP399677 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.7362 identify GeneRIF Biological Term Annotations 1.0 null GSE157555,GSE157556_5_v_1_foxa2_mouse RummaGEO Gene Perturbation Signatures -1.0 null EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.82677 PRKCI Pathway Commons Protein-Protein Interactions 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Perturb_2744_KD_MUC1_SRP214243 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.15443 urinary bladder HPA Tissue Protein Expression Profiles 1.0 0.891168 H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null mRNA_TBX3_16767105 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null trunk TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.068157 GSE113817_2_v_1_bach1_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_10096_KD_AGO3_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.55141 central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GTEX-U4B1-0826-SM-4DXTW GTEx Tissue Sample Gene Expression Profiles 1.0 0.959755 valproic acid_mus musculus_gpl6885_gse41020 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ZFC3H1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06144 GTEX-VUSG-0426-SM-3GIKD GTEx Tissue Sample Gene Expression Profiles 1.0 0.930844 Ciliary necklace COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.524 SUZ12-20075857-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.911523 CTCF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null metal metabolism disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.360764 GSE185163_5_v_2_clic4_mouse RummaGEO Gene Perturbation Signatures 1.0 null CD14+_Monocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.55963 GSE261563_0_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-J9-A52E-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U412-0006-SM-3DB8J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01445 HOXC13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.1889 GSE150055_0_v_1_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6351-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-557 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CB-55-AK76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.265236 MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.869103 CC-61-HH09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.326484 FC-85-OX77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.205446 GB-57-XV52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.28705 skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -0.906172 DA-10-GX45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.443772 MDA-MB-330 COSMIC Cell Line Gene CNV Profiles -1.0 -3.61078 GD-79-TW34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.315085 inner CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.24982 Interrenal cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.611 CDK19_knockdown_148_GSE32108 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.77904 Hand1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 25.016 Rhox11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.2856 H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null KM-H2 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.088 GTEX-OIZH-2626-SM-2HMJM GTEx Tissue Sample Gene Expression Profiles 1.0 0.871947 GSE223893_1_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null pancreas HPA Tissue Gene Expression Profiles -1.0 -1.07943 Lung squamous cell carcinoma_LUSC_TCGA-60-2710-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_14286_OE_YAPS94A_SRP336792 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.60717 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A57M-01A-51R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cuneate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.40091 AF-00-QK19_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.880772 H3K79me2_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SKMEL2 CCLE Cell Line Gene Expression Profiles 1.0 1.82336 fluocinolone acetonide_homo sapiens_gpl6480_gse16643 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cell-cell junction COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RERF-GC-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12009 ID-90-NM43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212709 RAD21_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null FB-66-UU47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.68029 CTCF_GM19239_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 19621087-Table1d GeneSigDB Published Gene Signatures 1.0 null hsa-miR-4422 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.11254 GSE48812_8_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15196 ATRFLOX Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.853415 GSE96641_1_v_2_esrp2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CYFIP2 Pathway Commons Protein-Protein Interactions 1.0 null ZIC5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 112.578 ZNF728 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.23735 GSE206226_2_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null C-33 A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.975945 PK-45H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.910625 Lung squamous cell carcinoma_LUSC_TCGA-22-5491-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE146687_2_v_5_eribulin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XPVG-0006-SM-4B65Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935655 Lung adenocarcinoma_LUAD_TCGA-55-8614-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QEG4-0006-SM-2I5FY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11698 PKNOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.229 SG in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05979 H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Mesothelioma_MESO_TCGA-SC-A6LN-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ciliary vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.889 184A1N4 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.53474 ONS76 DepMap CRISPR Gene Dependency 1.0 2.43093 LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.22362 hsa-miR-548y TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Acute Myeloid Leukemia_LAML_TCGA-AB-2982-03B-01T-0748-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-T5JC-0005-SM-4DM7B GTEx Tissue Sample Gene Expression Profiles -1.0 -2.86471 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-21-1078-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_15691_KO_p66/cRel_SRP075924 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.7878 GSE100316_7_v_4_mtor_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OIZI-0005-SM-2XCED GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71122 GTEX-PLZ5-1726-SM-2I5F6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.923588 GSE213588_9_v_11_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DNAJB1 Pathway Commons Protein-Protein Interactions 1.0 null ANKRD52 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.30041 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null cell junction organization GO Biological Process Annotations 2015 1.0 null GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930097 GTEX-XUZC-0005-SM-4BOQ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07004 GSE127970_1_v_0_ebf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4TZ-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null blood GTEx Tissue Gene Expression Profiles -1.0 -1.07008 GTEX-OHPN-0005-SM-2YUML GTEx Tissue Sample Gene Expression Profiles -1.0 -2.08559 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.911637 Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE7958 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.45177 HCC33 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.08859 SW 1990 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12009 GTEX-UJHI-1526-SM-3DB99 GTEx Tissue Sample Gene Expression Profiles 1.0 1.82847 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06768 GSE180185_4_v_5_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null Lung Diseases CTD Gene-Disease Associations 1.0 1.01212 SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.943056 H2AFZ_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 19192944-TableS4 GeneSigDB Published Gene Signatures 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-518a-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Cell-Cell communication Reactome Pathways 2014 1.0 null HD-51-KD29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.600076 parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.66391 GSE232631_0_v_1_brca2_mouse RummaGEO Gene Perturbation Signatures -1.0 null NFYB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0887 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null layer 2 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65248 hsa-miR-527 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 GSE48812_4_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null ventrolateral part of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3548 Periventricular hypothalamic nucleus, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25849 POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Asthma_Epithelial Cell_GSE4302 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.92837 regulation of cellular localization GO Biological Process Annotations 2023 1.0 null mammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37464 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51K-06A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDST8 CCLE Cell Line Gene Expression Profiles 1.0 1.51134 KLF5-20875108-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Primary somatosensory area, unassigned Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07972 cytoplasmic part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 hsa-miR-410 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043078 SG in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23499 GSE112860_5_v_4_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE237040_2_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null layer 1 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.79289 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null GSE221327_4_v_9_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A3PH-01A-11R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE243879_1_v_0_elapor1_human RummaGEO Gene Perturbation Signatures -1.0 null PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-WT-gene_symbol_CEBPA Rummagene Transcription Factor Associations 2026 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PTW/PP1 phosphatase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.985 gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.179239 GSE164874_5_v_9_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null AC-28-RT00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.417485 thyroid_5c HPA Tissue Sample Gene Expression Profiles 1.0 1.05692 GSE198165,GSE198166_9_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.79468 hsa-miR-3065-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 Perturb_8895_KD_FGD5_SRP281196 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.7404 CE-15-YU05_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.421785 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.911523 GSE77108_3_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SK-MEL-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.12714 GTEX-WXYG-2026-SM-4E3IY GTEx Tissue Sample Gene Expression Profiles 1.0 1.39285 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.12046 GSE112860_9_v_8_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KLF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 183.609 MC116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58057 hsa-miR-4796-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 component GeneRIF Biological Term Annotations 1.0 null PMC11216188-peerj-12-17616-s013.pdf-300-ZNF236_ZNF236 Rummagene Transcription Factor Associations 2026 1.0 null ECC10 CCLE Cell Line Gene Expression Profiles 1.0 1.59229 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MF-41-QM60_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.790726 GE-34-TW62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.23286 GTEX-SIU8-0126-SM-2XCDT GTEx Tissue Sample Gene Expression Profiles 1.0 1.4479 postcentral gyrus, right, inferior lateral aspect of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.846869 CTCF_retinal pigment epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-HB-A3L4-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RD-50-EO07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.555659 GTEX-Q2AI-1326-SM-2S1PL GTEx Tissue Sample Gene Expression Profiles 1.0 0.861373 DF-00-DK69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.13532 epithelioma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051299 GSE203308_9_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null HB-54-ZC59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.365229 MZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.02151 nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Perturb_2154_KD_SPRY1_ERP114848 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.04891 GSE184892_4_v_5_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null UE-58-EW15_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.485209 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RWSA-0126-SM-2XCBB GTEx Tissue Sample Gene Expression Profiles 1.0 2.19842 NALM16 DepMap CRISPR Gene Dependency 1.0 5.39756 GTEX-X4EP-0626-SM-3P621 GTEx Tissue Sample Gene Expression Profiles 1.0 0.860027 18086899-Table5 GeneSigDB Published Gene Signatures 1.0 null GTEX-TKQ2-0006-SM-33HBH GTEx Tissue Sample Gene Expression Profiles -1.0 -3.0495 DEOC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.78637 GTEX-OIZH-0005-SM-2HMJN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50002 primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.159 BA-53-FM66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.365381 H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KMM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14303 GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29212 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26525 HUNK_knockout_240_GSE14226 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.54464 Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T0-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hel HPA Cell Line Gene Expression Profiles -1.0 -0.926301 establishment or maintenance of epithelial cell apical/basal polarity GO Biological Process Annotations 2025 1.0 null GTEX-P44H-0226-SM-2XCEU GTEx Tissue Sample Gene Expression Profiles 1.0 1.67064 GSE146687_2_v_0_eribulin_human RummaGEO Drug Perturbation Signatures 1.0 null KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.57929 RA-42-CM42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.276475 PMC8481886-Table_1.xlsx-A_subsets-iMSC_fetal_MSC_UC_MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null BC-56-CP81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.284472 GSE239436,GSE239441_0_v_1_keap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7781-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MCF-7_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Thymus-endothelial cell of lymphatic vessel Tabula Sapiens Gene-Cell Associations 1.0 0.673907 ECGI10 CCLE Cell Line Gene CNV Profiles -1.0 -1.98143 dexamethasone_rattus norvegicus_gpl1355_gse29912 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null pancreas_6b HPA Tissue Sample Gene Expression Profiles -1.0 -1.03306 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.85235 GSE157894_1_v_3_cystine_human RummaGEO Drug Perturbation Signatures 1.0 null Small_Intestine-cd4-positive, alpha-beta t cell Tabula Sapiens Gene-Cell Associations 1.0 9.19667 CB-44-RT90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.45372 H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE158815_5_v_3_trib1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE124932_2_v_1_sarm1_mouse RummaGEO Gene Perturbation Signatures -1.0 null external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2226 Prelimbic area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1057 intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.060941 tight junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.16298 DA-85-SU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.76026 H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE225647_0_v_3_srsf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BE-92-TW08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.209582 layer 2 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01381 GTEX-XXEK-0005-SM-4BRWJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59875 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4884-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NF-21-HQ00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.263192 Ciliary basal body COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.931 GSE163920_1_v_0_sirt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC12179407-MCO2-6-e70261-s004.xlsx-up_TET3-KO_PQ_vs_Cas9_PQ-Unnamed_10_TET3 Rummagene Transcription Factor Associations 2026 1.0 null KLF6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 98.5047 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A8HS-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8113_KD_U2AF1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.31599 KLF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 125.481 layer 4 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.62485 GSE120370_0_v_6_thrombin_mouse RummaGEO Drug Perturbation Signatures 1.0 null TOLEDO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.01008 establishment or maintenance of apical/basal cell polarity GO Biological Process Annotations 2025 1.0 null GSE96641_5_v_0_esrp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Tiplaxtinin DeepCoverMOA Drug Mechanisms of Action -1.0 -0.29 bisphenol A CTD Gene-Chemical Interactions 1.0 null Perturb_10004_KD_KRR1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.4688 GSE217405_0_v_1_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE132948,GSE132949_0_v_3_msi2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE185944_0_v_1_pth1r_mouse RummaGEO Gene Perturbation Signatures -1.0 null DF-00-BU08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.216977 Perturb_46_OE_ERG/MYC_SRP069177 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.46072 ZNF281 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 256.801 PMC7403583-41598_2020_69884_MOESM2_ESM.xlsx-Sheet1-Supplementary_Table_1_Differentially_Expressed_Genes_FDR_q_0_05_in_U2932_ROCK2_KD_vs_Scrambled_shRNA_Constrols_AR Rummagene Transcription Factor Associations 2026 1.0 null GTEX-Q2AH-1626-SM-3GAF8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2349 H3K27me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE213588_9_v_7_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null SK-MEL-30 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.39814 Lung adenocarcinoma_LUAD_TCGA-55-7726-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-S3XE-0426-SM-3K2AC GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871453 GTEX-T5JC-0426-SM-32PLO GTEx Tissue Sample Gene Expression Profiles 1.0 1.21988 posteroventral (inferior) parietal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.27077 WDR83 Pathway Commons Protein-Protein Interactions 1.0 null dorsolateral prefrontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04935 Perturb_15690_KO_Rela/Rel_SRP075924 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -12.5039 ERF::NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.0036 NCIH69 CCLE Cell Line Gene CNV Profiles 1.0 1.9357 GSE85565_1_v_0_tcf21_human RummaGEO Gene Perturbation Signatures -1.0 null SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE125014_6_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.9745 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.835744 Perturb_4886_KD_WTAP_ERP019668 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.48108 JE-04-LS32_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.23799 primary motor cortex (area M1, area 4)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10435 epidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.910104 H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE71529,GSE71558_1_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures -1.0 null CDC42 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-320c TargetScan Predicted Conserved microRNA Targets 1.0 0.257113 U-2 OS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.2025 GSE169152_3_v_2_ibrutinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-UJHI-1726-SM-3DB9B GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88144 JA-85-SW39_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.34828 GSE247862,GSE247863_4_v_1_eomes_mouse RummaGEO Gene Perturbation Signatures 1.0 null tight junction GO Cellular Component Annotations 2023 1.0 null GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.879107 GTEX-PSDG-1326-SM-48TD2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.990396 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7263-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MARK1 Pathway Commons Protein-Protein Interactions 1.0 null hsa-miR-548c-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GTEX-N7MT-0326-SM-48TDP GTEx Tissue Sample Gene Expression Profiles 1.0 0.880466 MARK4 Pathway Commons Protein-Protein Interactions 1.0 null breast epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.419242 FF-28-ES17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.28336 CTCF_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NANOG ChEA Transcription Factor Targets 1.0 null GSE180200,GSE180201_5_v_11_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null MB-49-LL22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.343734 H3K27me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD34 Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-WHPG-2226-SM-3NMBO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833122 GTEX-XBEC-0006-SM-4AT5T GTEx Tissue Sample Gene Expression Profiles -1.0 -2.60774 GSE48812_9_v_5_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null GSE88819_7_v_8_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BD-61-OO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.421003 H3K4me3_CD19 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-6847-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE122101,GSE122103_3_v_4_ssu72_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-WRHK-1426-SM-3MJF9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.2588 layer 1 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19729 HDAC6 ENCODE Transcription Factor Targets 1.0 null GTEX-RWSA-0008-SM-47JYX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91832 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XL-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney Chromophobe_KICH_TCGA-KL-8326-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Tobacco Use Disorder HuGE Navigator Gene-Phenotype Associations 1.0 null DC-84-GJ21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.535284 CC-03-PW00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.779945 cuneate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.48007 EGR1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4282 TargetScan Predicted Conserved microRNA Targets 1.0 0.131849 GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22857 IgSF CAM signaling KEGG Pathways 2026 1.0 null NCIH1651 CCLE Cell Line Gene CNV Profiles -1.0 -2.3514 Lung squamous cell carcinoma_LUSC_TCGA-56-8622-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Atrial heart septal defect DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.05 AC-93-LT43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.262233 CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.9336 HNRNPK_02_136 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61298 GSE135514_8_v_7_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE111660_1_v_3_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null 496100508_PCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.87201 GTEX-RVPU-0005-SM-2TF6L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.88422 hsa-miR-214 TargetScan Predicted Conserved microRNA Targets 1.0 0.115091 Gastrointestinal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.252 GSE171311_0_v_1_ellagic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Astral microtubule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.132 BB-87-SF89_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.412742 Agranular insular area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77449 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null OLIG2 ChEA Transcription Factor Targets 1.0 null GTEX-S95S-1226-SM-4GICG GTEx Tissue Sample Gene Expression Profiles 1.0 1.21839 GTEX-P78B-1626-SM-2S1O1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.939895 RS4-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-S341-1726-SM-3K2AK GTEx Tissue Sample Gene Expression Profiles 1.0 2.09116 GSE162590_1_v_0_gsx2_mouse RummaGEO Gene Perturbation Signatures -1.0 null NIPSNAP1 Pathway Commons Protein-Protein Interactions 1.0 null HCT-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null rt4 HPA Cell Line Gene Expression Profiles 1.0 1.16076 GTEX-S7PM-0126-SM-4AD6S GTEx Tissue Sample Gene Expression Profiles 1.0 1.0788 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4894-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-VUSG-2526-SM-4KL1V GTEx Tissue Sample Gene Expression Profiles 1.0 1.63889 FOXA1 ENCODE Transcription Factor Targets 1.0 null Ciliary neurotrophic factor receptor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.6 Tight junction KEGG Pathways 2026 1.0 null PMC9643473-Table1.xls-MAF_0_005-Gene_refGeneWithVer_MAF Rummagene Transcription Factor Associations 2026 1.0 null primary motor cortex (area M1, area 4)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.94729 KB-46-EJ60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.299123 ventrolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.898959 thyroid_5b HPA Tissue Sample Gene Expression Profiles 1.0 0.880789 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A498-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RCOR1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPIC-1426-SM-4IHLQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.994619 GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.884655 GTEX-XAJ8-1426-SM-47JYM GTEx Tissue Sample Gene Expression Profiles 1.0 1.65704 Pseudohypoparathyroidism DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.072 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SSA3-0126-SM-32QPU GTEx Tissue Sample Gene Expression Profiles 1.0 1.35473 H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5585-01A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.859218 GSE233679_6_v_2_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null Hippo signaling pathway KEGG Pathways 2026 1.0 null GSE135030_8_v_10_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-OIZI-1426-SM-3NB1T GTEx Tissue Sample Gene Expression Profiles 1.0 0.918469 PANC 03.27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08685 YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WH7G-0426-SM-3NMBJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.904321 GSE103068_0_v_4_volasertib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE149123,GSE149128_3_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null BeWo cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.034 GTEX-RU72-0006-SM-2TF65 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.1634 WB-48-EF24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 4.67757 Perturb_7336_KD_SUGP1_SRP286876 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.35329 GSE129772_2_v_1_runx3_mouse RummaGEO Gene Perturbation Signatures 1.0 null EIF2AK4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36796 H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE198165,GSE198166_5_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE178532_2_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null LD-37-JE11_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.306265 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3N5-01A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE185944_5_v_4_pth1r_mouse RummaGEO Gene Perturbation Signatures 1.0 null BC-13-OQ01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.245216 Rectum adenocarcinoma_READ_TCGA-F5-6702-01A-11R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WC-09-GD62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.75921 Brain - Cerebellar Hemisphere GTEx Tissue Gene Expression Profiles 2023 1.0 4.29319 Penis_Foreskin_Melanocyte_Primary_Cells_skin03 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.924397 zonal layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5997 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null abnormality of the cardiovascular system GWASdb SNP-Phenotype Associations 1.0 0.042244 AD-30-VB23_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.3188 PSMD8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.39277 GTEX-TMZS-0126-SM-3DB9Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.11553 MFHAS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11163 KYSE-180 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.857727 mantle zone of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.34048 GSE206729_4_v_0_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null ZBED4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 164.762 outer CP in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.968875 H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE152432_9_v_4_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.96598 fertilizedegg BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.59593 Perturb_17732_KO_Tmprss2_SRP046010 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 16.6407 PB-09-OE00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.73726 EZH2_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tongueepidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.93646 Adrenal Gland GTEx Tissue Gene Expression Profiles 2023 1.0 1.29289 Perturb_14495_KO_Tcfl5_SRP322934 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -7.98889 GSE57871_1_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null NA-16-OJ70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.32447 GTEX-R55E-0826-SM-2TC5M GTEx Tissue Sample Gene Expression Profiles 1.0 0.879318 SNU213 CCLE Cell Line Gene CNV Profiles -1.0 -1.32372 U2OS CCLE Cell Line Gene Expression Profiles 1.0 2.09505 AA-71-XO01_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.243305 DAUDI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.69196 BT474 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.696385 GSE184892_0_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null LOXL2_DEPLETION_GDS4884_88_human_MDA-MB-231 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GTEX-P4PP-0005-SM-2HMKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53978 Chorionic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.851 Rectum adenocarcinoma_READ_TCGA-AG-3732-01A-11R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE166004_5_v_4_pld1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NA-16-OJ70_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.968275 GTEX-R55G-2526-SM-2TC6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.982325 9+2 non-motile cilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.848 GSE256181_2_v_0_etv2_human RummaGEO Gene Perturbation Signatures 1.0 null parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2844 MYC ENCODE Transcription Factor Targets 1.0 null SNU1544 DepMap CRISPR Gene Dependency 1.0 7.2275 Lung cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.182 PMC12500934-41408_2025_1358_MOESM3_ESM.xlsx-Table_S6-DEGs_p_0_05_between_surviving_or_deceased_DLBCL_patients_that_received_R-CHOP_therapy_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-X4EO-0326-SM-3P5YO GTEx Tissue Sample Gene Expression Profiles 1.0 1.46378 GSE184892_0_v_5_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null GSE94849_7_v_0_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PLZ5-2026-SM-2S1O4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.19125 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7434-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null Penis_Foreskin_Keratinocyte_Primary_Cells_skin02 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.957474 AD-16-HL96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.45286 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27582 XD-44-FJ34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.267965 Kidney Chromophobe_KICH_TCGA-KO-8408-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE168797_2_v_5_cannabidiol_human RummaGEO Drug Perturbation Signatures -1.0 null Supratrigeminal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06983 GSE48812_8_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WQ-01A-12R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE227592_13_v_1_adar_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PVOW-0006-SM-3NMB8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6635 Perturb_7780_KD_NUDT21_SRP017305 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.95674 GSE198165,GSE198166_7_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null SOX10 MotifMap Predicted Transcription Factor Targets 1.0 null hsa-miR-4725-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.824725 GSE127970_1_v_3_ebf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRF2-20460467-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7369-01A-11R-2132-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CA-42-YI34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.568151 Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-A8I2-01A-12R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE199255,GSE199356_4_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null GGA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11712 JC-06-ED36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.479826 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.974692 cell periphery COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-RN64-0126-SM-2TC68 GTEx Tissue Sample Gene Expression Profiles 1.0 1.01504 496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 7.4554 hsa-miR-4727-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.389112 Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5SQ-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE130396_1_v_6_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null posteroventral (inferior) parietal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.910054 GTEX-POMQ-0006-SM-33HBY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26708 GSE179002_2_v_7_caprin1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XOTO-0006-SM-4B64T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.974885 SOX2-21211035-LN229-GBM ChEA Transcription Factor Targets 2022 1.0 null GSE171175,GSE171181_1_v_2_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null periventricular stratum of RMa Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1021 MGAT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.36072 dexamethasone_homo sapiens_gpl6244_gse20963 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCIH1105 CCLE Cell Line Gene Expression Profiles 1.0 1.4814 CTCF_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1937 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.84869 H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HDAC2 ENCODE Transcription Factor Targets 1.0 null H3K9me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-W5WG-1926-SM-4KKZK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.851335 YAP1-20516196-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CTCF_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Aiolos_NULL MUTATION_GDS3473_572_mouse_Bone marrow pre-BII cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Spleen Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.06081 Cortical plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19108 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4878-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XUZC-2126-SM-4BRW8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16846 Perturb_763_KD_SRRM2_SRP366559 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.40347 GSE198165,GSE198166_5_v_10_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null PLAG1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 110.167 UBTF ENCODE Transcription Factor Targets 1.0 null DD-66-VY52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.271329 hsa-miR-133b TargetScan Predicted Conserved microRNA Targets 1.0 0.082179 KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.915584 GSE203308_15_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE96641_3_v_0_esrp2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9643473-Table1.xls-MAF_0_005-Gene_refGenecanonical_MAF Rummagene Transcription Factor Associations 2026 1.0 null Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.357 GTEX-P4QS-1626-SM-2S1NH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.904722 HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UMUC16 DepMap CRISPR Gene Dependency 1.0 3.91542 cytoplasmic part LOCATE Predicted Protein Localization Annotations 1.0 null HCC33 CCLE Cell Line Gene Expression Profiles 1.0 1.55393 PCI-15A COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_up-regulated_in_Myc_KD_hESC_AR Rummagene Transcription Factor Associations 2026 1.0 null upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.916822 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5889-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_9641_KO_HES7_SRP153047 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.45146 SIN3A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09391 adenocarcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052092 H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE146687_2_v_1_eribulin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XGQ4-0005-SM-4AT5U GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40691 H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE142210_3_v_10_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE84922,GSE84924_0_v_1_sall4_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR Rummagene Transcription Factor Associations 2026 1.0 null outer CP in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.01567 IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.94731 GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35304 GTEX-N7MT-0007-SM-3GACQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90595 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05088 H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null pontine nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17907 GTEX-PVOW-0126-SM-2XCFA GTEx Tissue Sample Gene Expression Profiles 1.0 1.97507 GTEX-TML8-1126-SM-4DXSS GTEx Tissue Sample Gene Expression Profiles 1.0 0.874186 Perturb_8356_KO_HKDC1_SRP346010 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2781 GSE213588_10_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null FE-61-DL94_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20226 EZH2_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WRHU-2826-SM-3MJG8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.55723 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4933_OE_KLF17_ERP131758 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.94689 GTEX-R55F-0005-SM-2TF4W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8364 AE-56-SL06_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.339523 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CE-69-HJ13_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.253206 TP53-23651856-MEF-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE178292_0_v_3_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-7338-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211126_3_v_4_hapln1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE226355,GSE226357_3_v_4_ybx1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE151612_0_v_8_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null HS852T CCLE Cell Line Gene Expression Profiles 1.0 1.43303 RAD21_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TADA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.52935 CTCF_GM12869_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null solitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.08933 GSE126345_4_v_3_hcrt_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13393_KD_AHR_SRP154013 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.14138 GTEX-WFON-2126-SM-3LK7O GTEx Tissue Sample Gene Expression Profiles 1.0 2.53824 breast cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.063739 AA-87-EI21_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.798506 ISL1-27105846-CHIP-SEQ-CPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ribavirin_homo sapiens_gpl570_gds4391 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Spinal nucleus of the trigeminal, oral part, caudal dorsomedial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16623 disease of metabolism GWASdb SNP-Disease Associations 1.0 0.087386 COGN305 DepMap CRISPR Gene Dependency 1.0 2.97079 lateral medullary reticular group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.31743 PMC4082364-supp_ddu111_ddu111supp_table9.xls-Tabelle1-Table_S9_MSC_WT1Wilms3_-_top_100_genes_down-regulated_MSC Rummagene Transcription Factor Associations 2026 1.0 null medial preoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.881015 PC-62-AQ92_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.361575 Perturb_12515_KD_TRA2B_SRP221583 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.45123 GSE60837_6_v_3_bcl9_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-4530 TargetScan Predicted Conserved microRNA Targets 1.0 0.072324 DA-19-JA87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.450509 GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3264 H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRN-0005-SM-2I5EU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.92868 WC-16-IR43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.446717 Mobilized_CD34_Primary_Cells_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.05013 PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-PBX3-Unnamed_4_PBX3 Rummagene Transcription Factor Associations 2026 1.0 null GSE57871_5_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE199255,GSE199356_3_v_5_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null FAM168A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.1245 PMC9314667-Table_1.xlsx-Regulons-IRF4_IRF4 Rummagene Transcription Factor Associations 2026 1.0 null AP-4 MotifMap Predicted Transcription Factor Targets 1.0 null BE-73-KD75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201679 GSE152432_5_v_2_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QV31-1426-SM-2S1QD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36387 NB4 DepMap CRISPR Gene Dependency 1.0 3.83368 HCC2279 CCLE Cell Line Gene Expression Profiles -1.0 -1.80376 H3K4me1_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null fulvestrant_homo sapiens_gpl570_gse22533 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18084 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29G-06A-12R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53518 PMC9894241-pnas.2211429119.sd05.xlsx-G2_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QDVJ-0005-SM-2TC5X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27654 PANC 02.03 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.911523 GSE142210_4_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null RERF-LC-MS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30525 UC-58-DM11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.61861 Lower respiratory tract disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.162 GTEX-T5JW-1826-SM-3GAE1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.844578 mantle zone of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91233 cellular component assembly GO Biological Process Annotations 2015 1.0 null Perturb_8244_KD_TAF15_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.25428 GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03305 Perturb_9150_KD_WTAP_SRP307037 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.68861 GSE112860_0_v_8_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17759 GE-53-SM76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.43065 GSE191174_0_v_1_ccdc92_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-R53T-0526-SM-3GADL GTEx Tissue Sample Gene Expression Profiles 1.0 0.949351 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7069-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FB-32-TL51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.468433 Lung adenocarcinoma_LUAD_TCGA-49-4487-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE70935_2_v_4_cyfip1_human RummaGEO Gene Perturbation Signatures -1.0 null SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EN1 JASPAR Predicted Transcription Factor Targets 1.0 null GSE193993_0_v_3_sstr2_human RummaGEO Gene Perturbation Signatures -1.0 null PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1 Rummagene Transcription Factor Associations 2026 1.0 null GSE154069_2_v_1_satb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null tight junction assembly GO Biological Process Annotations 2015 1.0 null AGS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.937403 superficial stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.6656 triangular septal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07608 GTEX-UPK5-1226-SM-4IHL8 GTEx Tissue Sample Gene Expression Profiles 1.0 0.83343 NCI-H2122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08856 GTEX-TMMY-1126-SM-4DXSX GTEx Tissue Sample Gene Expression Profiles 1.0 0.936538 PANC0213 CCLE Cell Line Gene Expression Profiles -1.0 -1.48571 CTCF_GM12873_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.853798 EZH2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AD-86-OB87_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.323006 Cytoproct COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.078 MDAMB415 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.911912 TEAD4_01_151 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.63561 doxorubicin_homo sapiens_gpl6947_gse25741 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XQ8I-0426-SM-4BOPO GTEx Tissue Sample Gene Expression Profiles 1.0 1.10653 OUMS-23 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.24188 occluding junction COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 GSE180200,GSE180201_15_v_11_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null DDHD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.15086 BC-61-BE07_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.2124 GTEX-X4EO-0006-SM-3P5ZF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23374 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6477-01A-11R-1873-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WB-82-EL69_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.385655 GSE118766_2_v_3_ifng_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null TP63 ChEA Transcription Factor Targets 1.0 null H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_2127_KO_SUMO2_SRP299611 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.940343 mediodorsal nucleus of thalamus_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12864 GSE211744_2_v_0_gdf15_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE231648_0_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null intermediate part of the arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15112 DCAF7 Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null tobacco use disorder GAD Gene-Disease Associations 1.0 null HS 675.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.960788 KLF13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 64.1644 GTEX-Q734-0006-SM-2I3FJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.956354 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null [Pyr1]-Apelin-13 DeepCoverMOA Drug Mechanisms of Action 1.0 0.24 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1PV-01A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null QA-07-KC40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.08418 GTEX-R55E-0008-SM-48FCG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.957967 GSE197850_4_v_3_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_cardiac muscle cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null T3M4 CCLE Cell Line Gene CNV Profiles -1.0 -1.33387 H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null posteroventral (inferior) parietal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.883539 GTEX-P78B-0526-SM-2I5F7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.910426 DD-74-PJ26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208399 H3K4me1_Brain Hippocampus Middle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051256 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of lung_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA ChEA Transcription Factor Targets 2022 1.0 null frontal cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06488 Perturb_8915_KO_KDM1A2a_SRP348808 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -7.1975 ChIP_ZFX_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KA-75-LP02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.42413 CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-3605-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 SP4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 211.893 skin HPA Tissue Gene Expression Profiles 1.0 1.82902 EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.72738 GSE168401_2_v_0_harmine_human RummaGEO Drug Perturbation Signatures 1.0 null Dynactin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.031 GSE183251_4_v_0_cyp2c70_mouse RummaGEO Gene Perturbation Signatures 1.0 null Endopiriform nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00503 GSE139239_2_v_6_ddr1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE219274,GSE219276_2_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null COLO792 CCLE Cell Line Gene Expression Profiles 1.0 1.5834 MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.0582 dorsal motor nucleus of the vagus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.12965 ESPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49004 HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20755 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-5243-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AB-25-XU75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.499987 SW 527 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.939163 CNOT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35056 MAPKAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34311 CTCF_astrocyte of the spinal cord_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE180200,GSE180201_15_v_1_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null Sebaceous gland disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.961 CHD7 ENCODE Transcription Factor Targets 1.0 null ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.92115 Uterine epithelium TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.648 Multimerin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.793 GSE195786_3_v_1_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null DA-58-LZ09_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.341679 Perturb_10078_KD_ZC3H8_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.26982 GSE77108_8_v_7_saha_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2855-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE249404_0_v_1_oxytocin_human RummaGEO Drug Perturbation Signatures -1.0 null midbrain reticular formation, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.8274 GSE191015_0_v_2_gsdmb_human RummaGEO Gene Perturbation Signatures 1.0 null UM-UC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.833591 GTEX-QLQW-0005-SM-2S1RA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6394 PA-15-CP52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201339 u698 HPA Cell Line Gene Expression Profiles -1.0 -1.1124 Trihydroxyisoflavone DeepCoverMOA Drug Mechanisms of Action 1.0 0.34 OB-17-DQ74_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.836429 TRP63-18441228-KERATINOCYTES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-PWO3-0005-SM-2I5FS GTEx Tissue Sample Gene Expression Profiles -1.0 -2.02931 GTEX-OIZI-0726-SM-2XCEI GTEx Tissue Sample Gene Expression Profiles 1.0 0.83345 AC-05-MR83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.14613 GTEX-X261-0326-SM-3NMD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.985581 CCDC85B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7811 Perturb_4601_KD_CD248_SRP250350 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.89375 endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055125 Perturb_3669_KO_FASTKD_SRP277516 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.74936 cellular_component GO Cellular Component Annotations 2015 1.0 null ES-WA7 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.20458 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 OCUM1 DepMap CRISPR Gene Dependency 1.0 2.06036 GSE198165,GSE198166_6_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null P63-26484246-CHIP-SEQ-KERATINOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.5141 Lung adenocarcinoma_LUAD_TCGA-64-5775-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE88819_11_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_12960_KD_YTHDC1_SRP309987 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GTEX-S4Z8-1826-SM-3K2BH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.832021 KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28349 alar part of terminal hypothalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41734 NCIH1355_LUNG CCLE Cell Line Proteomics 1.0 2.85726 posteroventral (inferior) parietal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00528 H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null DE-69-QQ25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.280114 PMC10245467-mmc3.pdf-247-E2F4_E2F4 Rummagene Transcription Factor Associations 2026 1.0 null GSE155031_5_v_1_dextran_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_HCT116_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Large_Intestine-cd8-positive, alpha-beta t cell Tabula Sapiens Gene-Cell Associations 1.0 2.23325 lateral parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.46477 GTEX-XAJ8-1026-SM-47JY9 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.89617 MA-104 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.823 GSE202434,GSE202438_13_v_11_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null Deuterosome COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.775 H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFE2L2 ChEA Transcription Factor Targets 1.0 null FOXA1-21915096-LNCAP-1F5-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE135350_2_v_7_dexamethasone_human RummaGEO Drug Perturbation Signatures 1.0 null primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.98104 G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.19866 breast epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.719934 EZH2 ENCODE Transcription Factor Targets 1.0 null GTEX-OIZG-0005-SM-2HMJC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01509 KLF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 151.289 NOMO1 DepMap CRISPR Gene Dependency 1.0 2.07611 SARS-CoV_60Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.65204 dorsolateral prefrontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.34489 placenta TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE235550_2_v_0_hspa9_human RummaGEO Gene Perturbation Signatures -1.0 null GSE57871_11_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures 1.0 null GSE128730_3_v_1_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A264-06A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE239844_7_v_9_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7752-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-W5X1-0006-SM-3GIJZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22595 DA-10-HD17_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.270163 Perturb_32_OE_ERG/MYC_SRP069177 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.78873 Axonemal dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.64 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_10108_KD_EIF4A3_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.34066 GB-57-XV52_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.53833 mRNA_NRIP1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null SKLMS1 CCLE Cell Line Gene Expression Profiles -1.0 -1.56669 GSE130956_2_v_1_icaritin_human RummaGEO Drug Perturbation Signatures -1.0 null Primary somatosensory area, unassigned, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20971 GSE88819_5_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.47495 KYSE-70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20755 GLMN CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58443 medial part of r9B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28995 Perturb_8073_KD_SNORD126_SRP337208 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.98428 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null JD-62-HR05_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.837421 GTEX-QESD-1426-SM-2S1R9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.71364 G402 DepMap CRISPR Gene Dependency 1.0 2.79161 GTEX-OXRO-0006-SM-2I5EM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.61314 DC-51-WE27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.114 GTEX-S341-1226-SM-4AD5S GTEx Tissue Sample Gene Expression Profiles 1.0 0.871742 hsa-miR-4775 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Perturb_7463_KD_RBM17_SRP126064 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 CHD1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZI-0626-SM-2XCEH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.949547 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5177-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 1 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.38893 hypoglossal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44162 GSE135439_0_v_1_pax5_human RummaGEO Gene Perturbation Signatures 1.0 null MD-86-UW46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.475965 GTEX-PSDG-0226-SM-33HC1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.8741 GSE195786_0_v_1_cisplatin_mouse RummaGEO Drug Perturbation Signatures -1.0 null PA-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.33816 CB-25-VR83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.33134 SP5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 66.6121 hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.989107 hsa-miR-4740-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 Lung squamous cell carcinoma_LUSC_TCGA-58-8391-01A-11R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE173201_2_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_15556_KO_SLFN11_SRP327912 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.80356 GSE221020,GSE221023_2_v_1_pten_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MTF2-20144788-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE237040_6_v_5_notch3_mouse RummaGEO Gene Perturbation Signatures -1.0 null adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055119 GTEX-OHPM-0006-SM-2HMKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76031 GSE152432_6_v_4_zrsr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Nephronophthisis 4 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.75 Lung adenocarcinoma_LUAD_TCGA-50-5044-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EBC1_LUNG CCLE Cell Line Proteomics 1.0 6.24245 PMC11033585-BLOOD_BLD-2023-021752-mmc2.xlsx-S10_DGEA_IKZF1-Supplemental_Table_10_Differentially_expressed_genes_between_IKZF1_and_all_other_subcluster_IKZF1 Rummagene Transcription Factor Associations 2026 1.0 null NB-12-ZK38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.376043 TFAP2C ChEA Transcription Factor Targets 1.0 null cytosol COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 KLF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 154.488 PMC12586484-41598_2025_22484_MOESM2_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_DEGs_in_ATOH8-depleted_EVT_ATOH8 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null FD-20-OG99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.812607 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE135514_8_v_3_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null Perturb_1742_KO_Drd2/Drd3_SRP215538 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.36207 GSE152441,GSE152442_6_v_3_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null orbital frontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.16614 VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.849642 GA-04-JM33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.266399 GTEX-S341-0006-SM-3NM8D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36081 GTEX-WQUQ-0006-SM-3MJF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18035 GSE128730_7_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null liver cirrhosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.192657 GSE221327_5_v_11_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null RNF2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6496-11A-01R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE118794_2_v_4_zmynd8_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE132948,GSE132949_2_v_3_msi2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-55-7724-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE239373_0_v_1_mettl3_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_HepG2_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-7823-01B-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF91 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26614 CTCF_astrocyte of the spinal cord_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AF-41-QY60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.991493 GSE154767_4_v_0_adam10_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_14173_KO_HOXBLINC_SRP149346 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.03167 Perturb_7266_OE_OspC1_SRP368098 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.27541 GTEX-UPJH-0326-SM-3GADU GTEx Tissue Sample Gene Expression Profiles 1.0 1.74329 supragenual nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78893 primary motor cortex (area M1, area 4)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.11852 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null ventromedial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.42843 GSE226355,GSE226357_1_v_0_ybx1_human RummaGEO Gene Perturbation Signatures -1.0 null MKN7 CCLE Cell Line Gene CNV Profiles -1.0 -1.63645 GSE193993_5_v_7_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null BC-10-SB73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.520496 GTEX-X261-0126-SM-3NMD6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.33667 mast cells BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.32935 S0-EE-YEKU_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.788585 Cell-cell junction organization Reactome Pathways 2024 1.0 null DDX19B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12554 Chlorsulfuron DeepCoverMOA Drug Mechanisms of Action 1.0 0.35 intermediate stratum of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.27704 SG in rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.51505 H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE86507,GSE86509_0_v_8_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null Cystic Fibrosis_Pancreas_GSE769 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.37133 GSE162739_6_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null BD-38-QC39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.23023 CTCF_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE143743_0_v_2_c9orf72_human RummaGEO Gene Perturbation Signatures 1.0 null Rectum adenocarcinoma_READ_TCGA-EI-6507-01A-11R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null medial tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11654 CE-18-ZM38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.356225 MEF2A JASPAR Predicted Transcription Factor Targets 1.0 null intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.047487 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null HCC2270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.20755 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70Q-01A-13R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_9966_KD_SF3A3_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.37415 occipital cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56392 LLGL1 Pathway Commons Protein-Protein Interactions 1.0 null Mesothelioma_MESO_TCGA-LK-A4O6-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R55C-0005-SM-3GAE9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20884 protein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042628 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE186483_2_v_4_lrrk2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Foxj3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 31.4389 GTEX-UPJH-0006-SM-3GACW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1006 Brain Lower Grade Glioma_LGG_TCGA-S9-A7IS-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null neuroblastoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HF-00-QG19_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.200812 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-A77P-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TTC709 DepMap CRISPR Gene Dependency 1.0 3.84137 NCI-H810 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.0052 BB-86-BE19_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.638871 H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null TA-19-YA45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.213997 GSE120612_6_v_1_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null MXI1 ENCODE Transcription Factor Targets 1.0 null GSE242333_0_v_2_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null PD-70-VS77_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.437721 parvocellular part of r8LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51471 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TGFBR2_knockout_296_GSE22989 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.90775 Perturb_13017_KO_ALOX5_SRP367905 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.48444 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XD-01A-22R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WT1-20215353-NEPHRON PROGENITOR-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BE-04-AN21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.902492 MAX_02_192 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.65473 GTEX-XUYS-0005-SM-47JZ2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.839094 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RM-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KLF11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 122.96 Perturb_3486_KO_Mettl3_SRP273291 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 18.2076 KDM5B ENCODE Transcription Factor Targets 1.0 null H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE65617_2_v_1_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE216538_1_v_3_mrs2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null FE-10-KQ78_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.413779 MCF12A Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.742651 hsa-miR-320a TargetScan Predicted Conserved microRNA Targets 1.0 0.257113 YY1 MotifMap Predicted Transcription Factor Targets 1.0 null MYO10 Pathway Commons Protein-Protein Interactions 1.0 null GSE239688_4_v_0_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null GF-32-FY02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.356331 CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4436a TargetScan Predicted Conserved microRNA Targets 1.0 0.283838 P300-27058665-CHIP-SEQ-ZR-75-30CELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null hsa-miR-3619-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.226173 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.04267 QE-48-NG07_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.364388 GTEX-PWN1-0126-SM-2I3FK GTEx Tissue Sample Gene Expression Profiles 1.0 1.86524 19962670-TableS3 GeneSigDB Published Gene Signatures 1.0 null GSE115363_2_v_4_esrrb_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_fibroblast of mammary gland_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217694_3_v_0_pold1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6932815-ppat.1007634.s011.xlsx-ST1_DGE_ELF1_lfc2_fdr05_interse-geneID_ELF1 Rummagene Transcription Factor Associations 2026 1.0 null GSE74528_0_v_1_trex2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE77108_6_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null Rap1 signaling pathway KEGG Pathways 2026 1.0 null 496100412_FWM_possible Alzheimer's disease_TBI_87_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.48436 H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC5550886-cddis2017345x3.xlsx-siRAD21_DEGs_NOT_rescued_by_Myc-Unnamed_1_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE114284_4_v_0_irf1_human RummaGEO Gene Perturbation Signatures -1.0 null BF-27-HP68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.468071 COV504 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.939512 midbrain raphe nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09118 GTEX-P4QR-0726-SM-2I5GO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.992949 Primary somatosensory area, trunk, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3712 H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE128333_2_v_0_tcf4_human RummaGEO Gene Perturbation Signatures 1.0 null EBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.0975 PMC5637904-PATH-243-193-s015.xlsx-human_up_in_ductal_SOX11-Table_S4A_Upregulated_genes_in_lesions_and_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_the_mammary_duct_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null nucleus LOCATE Predicted Protein Localization Annotations 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5332-01A-01R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null DBP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.96252 Uterine epithelial cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.675 periaqueductal gray substance, dorsolateral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.23783 TMEM209 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61057 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR Rummagene Transcription Factor Associations 2026 1.0 null HCC38 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.967222 JA-23-QE71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.773327 GSE136238_1_v_2_ebf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null EP300 ENCODE Transcription Factor Targets 1.0 null 184B5 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.02399 VA-19-EX85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.244355 AC-35-CK01_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.337259 H3K27me3_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-6591-01A-11R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 18081427-TableS8 GeneSigDB Published Gene Signatures 1.0 null GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.80834 GSE162892_4_v_2_isox_human RummaGEO Drug Perturbation Signatures -1.0 null VA-92-QP54_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.624898 GSE152432_3_v_2_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Primary somatosensory area, unassigned, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06008 CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.876299 YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE228413_4_v_3_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.80426 mRNA_NANOG_16767105 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null H3K27me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null AC-30-XU83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.330504 SLC27A3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.83132 GSE207611,GSE207612_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null HD-62-KE69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.278606 ZNF816 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 49.8984 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null bonemarrow_6b HPA Tissue Sample Gene Expression Profiles -1.0 -2.85798 ZNF148 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 170.865 GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.919903 GTEX-P78B-0005-SM-2I5GM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25144 JcP contribution to LTL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1164 GSE112860_5_v_8_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null BIN67 DepMap CRISPR Gene Dependency 1.0 2.76701 GSE165548_2_v_4_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Rectum adenocarcinoma_READ_TCGA-AG-3732-11A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE221327_5_v_9_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null GSE175787_4_v_10_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XUW1-0426-SM-4BOOT GTEx Tissue Sample Gene Expression Profiles 1.0 1.15544 gracile nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.20236 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6UY-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE135514_8_v_6_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X585-0005-SM-46MV3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12536 CC-18-YW57_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.289759 DE-30-UR76_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.412377 JD-44-KF86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.293692 Prdm15 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 42.7595 hsa-miR-548aa TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 GSE148066,GSE157787_8_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BD-69-XG81_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.738654 macromolecular complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 ventrolateral periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22871 Arid3b JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 15.9426 OE-31-YC41_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.16868 ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 1.2612 GSE143847_2_v_3_inhba_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H1568 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03034 GSE110580_1_v_0_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-PSDG-0726-SM-2I5FN GTEx Tissue Sample Gene Expression Profiles 1.0 0.935761 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A61V-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TC138 DepMap CRISPR Gene Dependency 1.0 3.24035 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A44S-01A-12R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE81803,GSE81912_0_v_1_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null r9 part of paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.6656 Perturb_12367_KD_SLC39A7_SRP274341 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE58724_1_v_4_oxymetholone_mouse RummaGEO Drug Perturbation Signatures 1.0 null UF-27-HS98_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.474549 CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.128 H3K9ac_Muscle Satellite Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE216273,GSE216292_0_v_7_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null Monogenic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.074 DD-74-PJ26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.341648 496100510_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.17634 tight junction KEGG Pathways 1.0 null DB-56-XL71_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.251229 Perturb_8693_KO_METTL1_SRP314965 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.12 NC-52-AG88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.843719 RL95-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_7425_KD_RBFOX2_SRP045481 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.11877 ZNF740 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.064 ELP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.35084 H3K4me3_Mobilized CD34 Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Uterine Cervical Neoplasms HuGE Navigator Gene-Phenotype Associations 1.0 null CA-48-CT20_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.377221 GB-06-BA49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.86659 GSE95688_7_v_2_glutathione_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE86507,GSE86509_3_v_10_hoxb7_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null lateral pallium Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44099 GSE157383_0_v_1_abemaciclib_human RummaGEO Drug Perturbation Signatures 1.0 null SW 1116 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.10737 YE-46-YA12_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.62786 Perturb_771_KD_SRRM1_SRP366559 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.68156 GSE147662_2_v_4_nicotinamide_mouse RummaGEO Drug Perturbation Signatures 1.0 null SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.44381 GTEX-TKQ1-0006-SM-33HBI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20614 GSE128099,GSE128159_3_v_2_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null layer IIIu of area 35r Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.970516 Perturb_9084_KO_NSUN2_SRP400807 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.28673 hsa-miR-498 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 CTCF_H1-hESC_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null insular cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.34048 snoutepidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.08171 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3CC-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CEBPD-21427703-3T3-L1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE190316,GSE190324_1_v_11_rbm4_human RummaGEO Gene Perturbation Signatures -1.0 null GSE100102_4_v_6_cgas_mouse RummaGEO Gene Perturbation Signatures -1.0 null ENTPD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4305 POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null JEG-3 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.663 ZIC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 83.9075 SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.58109 H3K4me1_Breast vHMEC Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE155031_5_v_3_dextran_human RummaGEO Drug Perturbation Signatures -1.0 null all GWASdb SNP-Phenotype Associations 1.0 0.031937 irf6_17041601_skin_lof_mouse_gpl1261_gds2359 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.099911 DA-35-DU85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.640662 SNAPC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39272 G140 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03079 PMC4872073-supp_gkv1528_nar-02930-x-2015-File004.xlsx-Table_S2C-CREB1_FoxA1_Target_Genes_CREB1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-VJYA-0005-SM-3P5ZD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41126 GSE86507,GSE86509_7_v_2_hoxb7_mouse RummaGEO Gene Perturbation Signatures 1.0 null EIF5A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21474 mantle zone of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.546 H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.61535 GSE206226_2_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null Integral component of presynaptic membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.903 H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S3XE-1726-SM-3K2AM GTEx Tissue Sample Gene Expression Profiles 1.0 1.54538 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F7_E2F7 Rummagene Transcription Factor Associations 2026 1.0 null MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.827618 disease by infectious agent DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040768 trans-Golgi network membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.634 Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KT-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5J8-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterodorsal preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.88984 superior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.857657 lateral terminal nucleus of the accessory optic tract, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34683 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.938709 H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null angular gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.60367 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6950-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-E2F1_E2F1 Rummagene Transcription Factor Associations 2026 1.0 null protein complex GO Cellular Component Annotations 2015 1.0 null GSE242096,GSE242098_1_v_0_med1_mouse RummaGEO Gene Perturbation Signatures -1.0 null MKN45 CCLE Cell Line Gene CNV Profiles 1.0 1.44723 Bronchoalveolar stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.927 GSE242049_1_v_0_glutathione_mouse RummaGEO Drug Perturbation Signatures -1.0 null embryonic structure TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE118816_2_v_1_myo1c_human RummaGEO Gene Perturbation Signatures 1.0 null GSE175787_4_v_2_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null AF-72-PP21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.494558 DC-93-NP78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.62813 H3K27me3_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVCAR4 CCLE Cell Line Gene CNV Profiles -1.0 -1.42639 YY1 JASPAR Predicted Transcription Factor Targets 1.0 null PNMAL1 Pathway Commons Protein-Protein Interactions 1.0 null Accessory olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0849 paraterete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1598 GSE245418_0_v_2_cd109_human RummaGEO Gene Perturbation Signatures -1.0 null NCIH810 CCLE Cell Line Gene Expression Profiles -1.0 -1.63294 GSE153871_0_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_2_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7046-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60548 GSE231891_1_v_0_cdk8_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_cardiac fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MZ in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.62327 mantle zone of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06983 AB-18-YN11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.460621 Perturb_10035_KD_PUM1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.39273 H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8428-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE93309_2_v_4_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RC-52-AC88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.438811 H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ID-00-IC14_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.203203 establishment or maintenance of epithelial cell apical/basal polarity GO Biological Process Annotations 2023 1.0 null PMC3610249-1471-2164-14-184-S4.xls-miR-331-3p_targets-NR2E3_NR2E3 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RUNX1 ChEA Transcription Factor Targets 1.0 null GSE244710_1_v_2_srsf1_human RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04105 cell junction GO Cellular Component Annotations 2015 1.0 null AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.449982 dorsolateral prefrontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.894113 GSE137818_5_v_0_brca2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SW1417 COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_90_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null frontal pole, left, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.4556 ZNF416 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.5884 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV2-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OE-78-XD40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.03962 dorsolateral prefrontal cortex_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.965276 SA-31-VB03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.592931 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null YWHAH Pathway Commons Protein-Protein Interactions 1.0 null PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE142684_3_v_5_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE112763,GSE112767_4_v_1_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null BA-56-QV45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 3.35789 H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S32W-2126-SM-2XCB1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.44621 endoplasmic reticulum LOCATE Predicted Protein Localization Annotations 1.0 null GSE205730,GSE205731_2_v_3_tazemetostat_human RummaGEO Drug Perturbation Signatures 1.0 null HES3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22154 CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.936307 abducens nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41044 GSE112762,GSE112767_2_v_0_dgcr8_mouse RummaGEO Gene Perturbation Signatures -1.0 null OC-10-FB51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.295656 central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.1986 GSE175787_13_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.40694 GTEX-R55E-1326-SM-48FCR GTEx Tissue Sample Gene Expression Profiles 1.0 1.04974 PRKCZ Hub Proteins Protein-Protein Interactions 1.0 null KURAMOCHI_OVARY CCLE Cell Line Proteomics 1.0 2.85726 AF-80-GK24_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.400614 SLC43A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.77258 FOXA1_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE130401_4_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.899852 GSE58724_3_v_4_oxymetholone_mouse RummaGEO Drug Perturbation Signatures 1.0 null TC205 DepMap CRISPR Gene Dependency 1.0 3.30792 Brain Lower Grade Glioma_LGG_TCGA-DU-A7TB-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Necrosis CTD Gene-Disease Associations 1.0 1.23806 CTCF_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4154-01A-01R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE156115_0_v_3_igf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE176555,GSE176556_1_v_0_acriflavine_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_9882_KD_UTP3_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.23132 Perturb_8914_KO_KDM1A_SRP348808 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -12.1044 GA-28-SS67_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.605433 AB-85-JR73_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.378868 hsa-miR-374c TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 GTEX-XQ8I-0926-SM-4BOOF GTEx Tissue Sample Gene Expression Profiles 1.0 1.28238 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE89767_1_v_5_cebpa_mouse RummaGEO Gene Perturbation Signatures 1.0 null spinal trigeminal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.960603 CTCF_GM12871_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCAS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.862688 GSE226316_11_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE223287,GSE223290_2_v_4_braf_mouse RummaGEO Gene Perturbation Signatures 1.0 null growth abnormality GWASdb SNP-Phenotype Associations 1.0 0.511041 DLD-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_left-y_TFEB_KO_LLOMe_VS_WT_LLOMe_DOWN_TFEB Rummagene Transcription Factor Associations 2026 1.0 null NT5DC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00052 SU8686 CCLE Cell Line Gene CNV Profiles -1.0 -1.83705 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34735 GSE155305_3_v_0_ifitm3_mouse RummaGEO Gene Perturbation Signatures 1.0 null AB-74-VK99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.538132 GSE135705_5_v_3_corticosterone_mouse RummaGEO Drug Perturbation Signatures -1.0 null centriole GeneRIF Biological Term Annotations 1.0 null JB-74-LF71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214268 CTCF_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IGR-37 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.37704 GSE152441,GSE152442_0_v_3_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.1328 SAP30 ENCODE Transcription Factor Targets 1.0 null GTEX-Y8E5-0006-SM-47JWQ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.07881 GTEX-PWO3-1526-SM-48TCM GTEx Tissue Sample Gene Expression Profiles 1.0 1.24152 PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null H3K27me3_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null QE-79-XO29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.05312 perimammillary part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23535 Perturb_12517_KD_TRA2B_SRP221583 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 13.6009 SIMA DepMap CRISPR Gene Dependency 1.0 3.78041 GSE145323,GSE145324_1_v_0_rfx3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-5963-02A-12R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATP11B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23075 SLC31A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31634 AB-96-XV75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.27253 RT4 CCLE Cell Line Gene Expression Profiles 1.0 2.04151 G124 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.865715 GSE79291_1_v_2_streptozotocin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-U3ZM-1226-SM-3DB9G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95582 GSE48812_4_v_10_sulforaphane_human RummaGEO Drug Perturbation Signatures -1.0 null superficial stratum of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1164 COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.22708 PNMA3 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-OXRN-0126-SM-48TDM GTEx Tissue Sample Gene Expression Profiles 1.0 1.21043 HCC70 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.39296 medial mammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47145 TCFAP2C-20176728-TROPHOBLAST STEM CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null breast cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061804 GTEX-WL46-0126-SM-3TW8I GTEx Tissue Sample Gene Expression Profiles 1.0 0.857543 hsa-miR-590-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 orbital frontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.38591 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 layer 5 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81026 BA-19-VU85_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.325382 Septic Shock_Whole blood_GSE9692 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.66677 Small_Intestine-cd8-positive, alpha-beta t cell Tabula Sapiens Gene-Cell Associations 1.0 3.43782 Skin Ulcer CTD Gene-Disease Associations 1.0 1.05793 GSE240468_3_v_2_nfyc_human RummaGEO Gene Perturbation Signatures -1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H0-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Mammillary body Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13654 H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6348-11A-01R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.172 Perturb_8922_KD_ARID1A_SRP192521 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.66186 TFAP2C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 168.097 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE194396,GSE194429_2_v_3_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null Medial amygdalar nucleus, anteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.29556 EBC1 CCLE Cell Line Gene CNV Profiles -1.0 -1.35708 H3K9ac_Brain Substantia Nigra Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null GSE174498,GSE174500_2_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null Contractile vacuole pore COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.166 GTEX-WWYW-0005-SM-3NB3K GTEx Tissue Sample Gene Expression Profiles -1.0 -2.39718 Anterior cingulate area, dorsal part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.018 inflammatory bowel disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.201635 ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM10266_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_9964_KD_NSUN2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.81699 GSE203308_4_v_10_brf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SARS-dORF6_84Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.88353 Basal cortex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.454 Lateral reticular nucleus, parvicellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.59308 SG in posterior frontal cortex (motor cortex) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.994089 PARD6B Pathway Commons Protein-Protein Interactions 1.0 null H3K4me2_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PX3G-0126-SM-2I3EN GTEx Tissue Sample Gene Expression Profiles 1.0 2.62071 ZE-45-CG69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.226378 H3K4me3_Skeletal Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_9890_KD_HNRNPM_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.34875 GSE228106_0_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null Cardiac Failure_Myocardial tissue_GSE1988 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.70628 POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4RF-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Field CA2, stratum oriens Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1057 GTEX-P4PP-0126-SM-3LK69 GTEx Tissue Sample Gene Expression Profiles 1.0 1.39002 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_93_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null C170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null pb1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.774 central medullary reticular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.881177 Adrenocortical carcinoma_ACC_TCGA-OR-A5J5-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XMD1-0006-SM-4AT4Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.52731 GSE135030_11_v_5_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-SUCS-1626-SM-32PLS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.922914 Perturb_17613_KI_FOXP2_SRP225889 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 18.9586 PMC12179525-mmc1.xlsx-Group_HNF4A_vs_Null_sign-Supplemental_Table_S1_Differentially_expressed_genes_in_HNF4A-transduced_cells_vs_Null_HNF4A Rummagene Transcription Factor Associations 2026 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70E-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FAM98C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18179 GTEX-XK95-1026-SM-4GIDV GTEx Tissue Sample Gene Expression Profiles 1.0 0.904456 Stat6 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.9908 H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.84547 MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL-85-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.90401 GEO cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.608 GD-82-CS38_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.46962 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PLAGL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 100.116 Tuberomammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.31473 GSE217552_3_v_5_fisetin_human RummaGEO Drug Perturbation Signatures -1.0 null EPI-1622-1 (NCK1) NURSA Protein Complexes 1.0 null GSE132948,GSE132949_2_v_5_msi2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null regulation of cellular localization GO Biological Process Annotations 2025 1.0 null Anterior cingulate area, dorsal part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16623 STAG2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04574 superficial stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.91392 TRIB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.21505 GA-28-SS67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.268275 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A6B6-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-X88G-0126-SM-47JZ3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.70044 hsa-miR-548ab TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GSE180200,GSE180201_5_v_1_qpctl_mouse RummaGEO Gene Perturbation Signatures 1.0 null XD-08-ZW85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.268217 HES7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.1136 ZB-29-GC39_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.616589 Neuroblastoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 AB-30-CR11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.799144 GSE146687_2_v_6_eribulin_human RummaGEO Drug Perturbation Signatures 1.0 null JHUEM1 DepMap CRISPR Gene Dependency 1.0 7.9257 GSE261563_6_v_1_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null nucleus GO Cellular Component Annotations 2025 1.0 null retromammillary area, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18518 subcallosal cingulate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.46414 ASPC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00232 Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-A4CB-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null NE-94-VE83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.03344 medial parabrachial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.66099 GTEX-OXRK-0006-SM-2HML1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.94908 GTEX-Q2AG-0826-SM-2HMKF GTEx Tissue Sample Gene Expression Profiles 1.0 1.04617 GSE123022,GSE123030_2_v_0_trem2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Field CA1, stratum pyramidale Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29978 U2OS CCLE Cell Line Gene CNV Profiles 1.0 2.45583 GTEX-XUZC-1726-SM-4BRWS GTEx Tissue Sample Gene Expression Profiles 1.0 1.24421 breast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.305001 primary somatosensory cortex (area S1, areas 3,1,2)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.880757 integument TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053357 fetus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE100102_0_v_6_cgas_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-507 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 AA-52-JS03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.268475 SARS-ddORF6_24Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.45189 dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.370067 OD-03-CA36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.440483 SB-28-EJ14_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.217882 H3K4me1_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null DE-30-UR76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.424384 PNMA1 Pathway Commons Protein-Protein Interactions 1.0 null HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Paraventricular nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07535 SOX2-21211035-LN229_GBM-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null layer 1 of FCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12171 AC-71-YF45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.362044 BB-86-BE39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.279343 GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.974688 GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12724 primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09751 GSE231648_4_v_3_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OCUG1 DepMap CRISPR Gene Dependency 1.0 2.1333 inferior frontal gyrus, opercular part, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.03784 dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.868268 AE-95-UU45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.063 FB-66-UU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.786892 Lung adenocarcinoma_LUAD_TCGA-62-8399-01A-21R-2326-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null skmel30 HPA Cell Line Gene Expression Profiles 1.0 0.918327 SUIT-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.80643 brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE195568_6_v_10_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null RPMI 2650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.45203 PMC5637904-PATH-243-193-s015.xlsx-human_up_in_ductal_SOX11-Unnamed_7_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null GSE213588_8_v_13_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE226285_3_v_0_nr0b1_human RummaGEO Gene Perturbation Signatures 1.0 null AA-23-FM46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.395953 GTEX-WEY5-0006-SM-3GIKG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.67213 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GT-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null spleen BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.06881 Infection by Yersinia enterocolitica_macrophage_GSE2973 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.34414 OLIG2-23332759-OLIGODENDROCYTES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null thyroid gland HPA Tissue Gene Expression Profiles 1.0 0.883217 Primary somatosensory area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53027 Lalistat1 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.36 CE-96-GH46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.740885 GSE135030_11_v_4_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null organism form TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null FLI1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Perturb_7963_OE_DKC1_SRP103222 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.73552 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.00218 VD-88-MW70_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.94297 H3K27me3_kidney epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DQX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30577 cell-cell junction assembly GO Biological Process Annotations 2015 1.0 null GTEX-S4UY-0126-SM-3K2BB GTEx Tissue Sample Gene Expression Profiles 1.0 1.20239 CTCF_endothelial cell of umbilical vein_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZBTB24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 101.03 chemdependency GAD High Level Gene-Disease Associations 1.0 0.293278 macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042253 SA-53-XG95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.286977 frontal pole, right, medial aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.59468 dactinomycin_homo sapiens_gpl7172_gse12459 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Adrenocortical carcinoma_ACC_TCGA-P6-A5OG-01A-22R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WHPG-0006-SM-3NMBV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3834 GTEX-QXCU-0326-SM-2TC63 GTEx Tissue Sample Gene Expression Profiles 1.0 0.899223 GTEX-UPJH-0226-SM-3GADV GTEx Tissue Sample Gene Expression Profiles 1.0 2.00205 GSE240896,GSE240899_2_v_4_ccnt1_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-634 TargetScan Predicted Conserved microRNA Targets 1.0 0.045136 GSE128730_4_v_6_neratinib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SUIT-2 COSMIC Cell Line Gene CNV Profiles -1.0 -3.61078 NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.967222 AD-11-RL84_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.261256 GSE138863_3_v_0_disulfiram_human RummaGEO Drug Perturbation Signatures 1.0 null LEF1-29337183-MESC-MOUSE-STEM ChEA Transcription Factor Targets 2022 1.0 null GSE185163_3_v_1_clic4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-TMMY-0426-SM-33HBB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.931029 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null HF-91-IU60_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.255886 Syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.032 CB-16-SY72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.571334 GTEX-TKQ1-1026-SM-4GICL GTEx Tissue Sample Gene Expression Profiles 1.0 1.19719 GSE198165,GSE198166_7_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null HINFP JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-P4QR-0006-SM-2I5GN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.82604 Microspike COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.592 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Placenta TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 posterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.848146 H3K27me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-IH-A3EA-01A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Integral component of synaptic membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.621 CTCF_MCF-7_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tirofiban DeepCoverMOA Drug Mechanisms of Action 1.0 0.28 GSE239844_6_v_2_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null premotor cortex (area 6) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.847577 hsa-miR-320b TargetScan Predicted Conserved microRNA Targets 1.0 0.265648 AC-84-QG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.594639 KLF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09217 GTEX-XOTO-0126-SM-4B66N GTEx Tissue Sample Gene Expression Profiles 1.0 1.50293 POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE222758_0_v_1_clofazimine_human RummaGEO Drug Perturbation Signatures -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.12332 GSE152441,GSE152442_0_v_4_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null EE-01-FB85_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.740968 FCF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34537 GTEX-SN8G-0006-SM-32PLD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77241 NCO2 CCLE Cell Line Gene CNV Profiles 1.0 1.42652 PMC6932815-ppat.1007634.s014.xlsx-ST4_DGE_ELF1-R8AvIFN6-mock_lfc2-ensembl_gene_id_ELF1 Rummagene Transcription Factor Associations 2026 1.0 null daudi HPA Cell Line Gene Expression Profiles -1.0 -2.29909 SUIT2 CCLE Cell Line Gene CNV Profiles -1.0 -2.74606 inferior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.93773 GTEX-Q2AG-0126-SM-33HBV GTEx Tissue Sample Gene Expression Profiles 1.0 1.41248 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.057864 FOSL1_KO_GSE43695_680_mouse_lung, PBS treatment GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null dorsomedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15753 GSE114690_2_v_0_tnfsf14_mouse RummaGEO Gene Perturbation Signatures -1.0 null SRC-2_KO_GDS5087_485_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE188570,GSE188571_5_v_2_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RWSA-0005-SM-2XCAO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04832 CEBPB-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC6932815-ppat.1007634.s014.xlsx-ST4_DGE_ELF1-R8AvIFN6-mock_lfc2-external_gene_name_ELF1 Rummagene Transcription Factor Associations 2026 1.0 null GSE151119_2_v_0_hsf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.891893 GSE202284,GSE202289_5_v_4_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE148066,GSE157787_0_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BE-90-YK54_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.32277 H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Umbilical hernia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.381 GSE153189_1_v_3_stat1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NA-16-OJ70_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.983658 Perturb_9992_KD_PABPC1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.13618 r8 part of the paragigantocellular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58383 GSE183316,GSE183317_3_v_2_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BB-20-UU03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.81991 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_102_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.945149 GSE226316_1_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Agranular insular area, dorsal part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91233 GTEX-R55E-0006-SM-2TC5G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17184 ZNF740 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 160.434 GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11334 COLO824 DepMap CRISPR Gene Dependency 1.0 3.66282 GTEX-OXRO-1226-SM-48TDL GTEx Tissue Sample Gene Expression Profiles 1.0 1.22837 SHSY5Y DepMap CRISPR Gene Dependency 1.0 3.29207 H3K27me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE236486_1_v_0_arnt_human RummaGEO Gene Perturbation Signatures 1.0 null inner CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.82341 HCC2998 COSMIC Cell Line Gene Mutation Profiles 1.0 null AE-32-DP61_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222993 PHF8 ENCODE Transcription Factor Targets 1.0 null BCLAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18863 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25131 EP300_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TLN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0178 H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SARS-CoV_60Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.3274 UST CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01583 rostral subdivision of medial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.87916 composition GeneRIF Biological Term Annotations 1.0 null PACADD137 DepMap CRISPR Gene Dependency 1.0 3.27152 FF-86-NH56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.33518 GSE199541_2_v_4_mbd2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE151782_2_v_7_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Perturb_12516_KD_TRA2B_SRP221583 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.5785 CTCF_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null YAP1-20516196-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-4482 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 20220088-SuppTable1 GeneSigDB Published Gene Signatures 1.0 null GTEX-OHPL-0006-SM-3MJHB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43184 Hepatoblastoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.03 Acute Myeloid Leukemia_LAML_TCGA-AB-2847-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null WF-96-ME07_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.357523 GSE216538_7_v_4_mrs2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE233679_5_v_9_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WHPG-2626-SM-3NMBR GTEx Tissue Sample Gene Expression Profiles 1.0 1.44756 EZH2_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6898 PANC0504 DepMap CRISPR Gene Dependency 1.0 3.69805 dorsolateral prefrontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.98104 DOCK7 Pathway Commons Protein-Protein Interactions 1.0 null animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null r9 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19204 SLC1A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23227 kidney HPA Tissue Protein Expression Profiles 1.0 1.27722 bone marrow HPA Tissue Gene Expression Profiles -1.0 -1.75995 GA-28-SS67_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.435621 H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X5EB-2226-SM-46MW4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.63555 H9 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.06011 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TV-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE79572_0_v_1_pax8_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF354B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34057 AC-35-CK01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.328963 NCIH747 CCLE Cell Line Gene CNV Profiles -1.0 -1.62569 T24_URINARY_TRACT CCLE Cell Line Proteomics 1.0 4.46104 Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3RC-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4690-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GSE167474_1_v_0_naa40_human RummaGEO Gene Perturbation Signatures 1.0 null dorsolateral prefrontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.874614 Perturb_15558_KO_SLFN11_SRP327912 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.36195 cell junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.070376 LD-39-FL02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.374944 RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CORL95 CCLE Cell Line Gene CNV Profiles 1.0 2.0011 hsa-miR-3187-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 dorsolateral prefrontal cortex_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0001 KELLY CCLE Cell Line Gene CNV Profiles 1.0 1.36491 CTCF_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PATZ1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 294.776 disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039675 DB-54-GQ68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.53078 superficial stratum of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12706 medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.62753 GTEX-OIZH-0126-SM-2HMIS GTEx Tissue Sample Gene Expression Profiles 1.0 1.65363 hsa-miR-764 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 PNPLA5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03478 ChIP_H3K27me3_17603471_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null FOXA1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PD-05-HV36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.19621 IC-05-AW29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.244358 PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null YWHAE Hub Proteins Protein-Protein Interactions 1.0 null H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_5834_KO_Lin28b_SRP062991 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 GSE210885_5_v_7_klf4_mouse RummaGEO Gene Perturbation Signatures -1.0 null SRC-2_Deficiency_GDS5087_270_mouse_Heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null AB-71-CI37_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.929057 GSE58724_3_v_0_oxymetholone_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE198165,GSE198166_0_v_3_zfp266_mouse RummaGEO Gene Perturbation Signatures -1.0 null Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.2082 GTEX-XPVG-2126-SM-4B667 GTEx Tissue Sample Gene Expression Profiles 1.0 1.40111 COLO-783 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.13238 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.93602 H3K9ac_Colonic Mucosa Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-QDVJ-1726-SM-2I5FX GTEx Tissue Sample Gene Expression Profiles 1.0 1.19176 CYFIP1 Pathway Commons Protein-Protein Interactions 1.0 null CTCF_Caco-2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GA-88-CF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.249521 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XBED-2226-SM-47JYQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.39054 GSE120370_4_v_3_thrombin_mouse RummaGEO Drug Perturbation Signatures -1.0 null NCIH2126 CCLE Cell Line Gene CNV Profiles -1.0 -1.73427 H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RM2N-1626-SM-2TF5N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.949205 GTEX-S4UY-0006-SM-3K2A7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.8491 GSE122067_3_v_1_mtch2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Metaphase plate COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.679 outer CP in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.953019 H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-3973 TargetScan Predicted Conserved microRNA Targets 1.0 0.336728 primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.2229 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RO-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.8907 GSE93309_2_v_0_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC3906982-1471-2164-14-830-S1.xlsx-Sheet1-Table_S1_HOXC9-responsive_genes_HOXC9 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WFON-0005-SM-3NMC9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20658 OCILY3 CCLE Cell Line Gene CNV Profiles 1.0 2.29858 17555561-Table2 GeneSigDB Published Gene Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-5360-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Oral apparatus COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.674 BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.49822 GTEX-O5YV-2026-SM-2D7VS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.878916 GSE139016_3_v_1_disulfiram_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WHWD-1826-SM-3LK6I GTEx Tissue Sample Gene Expression Profiles 1.0 2.03429 GSE223893_2_v_10_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null macromolecular complex GO Cellular Component Annotations 2015 1.0 null CB-73-HZ47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.339233 GSE210101,GSE210114_8_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null sublayer 6b of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77449 496100536_HIP_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.17645 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.920197 superficial stratum of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2171 MDST8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.02454 enzalutamide_homo sapiens_gpl570_gse44905 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Kidney Chromophobe_KICH_TCGA-KN-8428-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RPL17 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.74159 CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DB-21-FY75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.640992 GSE152441,GSE152442_6_v_4_folic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GSE138001_2_v_4_rorb_mouse RummaGEO Gene Perturbation Signatures 1.0 null posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.986506 SW 780 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14547 AD-11-HV98_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.311 GTEX-RM2N-1426-SM-2TF4H GTEx Tissue Sample Gene Expression Profiles 1.0 1.38243 BB-42-FF52_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.371028 Prostate adenocarcinoma_PRAD_TCGA-H9-A6BX-01A-31R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5693-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5637904-PATH-243-193-s015.xlsx-human_up_in_ductal_SOX11-Unnamed_6_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null ventrolateral prefrontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.851105 GSE180185_4_v_8_setbp1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Respiratory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.166 GSE182179_2_v_3_kdsr_human RummaGEO Gene Perturbation Signatures -1.0 null GSE197850_4_v_2_glucagon_human RummaGEO Drug Perturbation Signatures -1.0 null GSE77108_5_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null MKN-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47815 EA-84-SC49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.384183 GTEX-S4UY-0526-SM-3K2AN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.884457 GTEX-SE5C-1126-SM-4BRWZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.17671 H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AC-31-PL89_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.67564 LLGL2 Pathway Commons Protein-Protein Interactions 1.0 null GSE183413_0_v_2_ash1l_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me2_H1 BMP4 Derived Mesendoderm Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null FE-56-PV35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.594592 H3K4me3_Pancreatic Islets Roadmap Epigenomics Histone Modification Site Profiles 1.0 null orbital frontal cortex_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.923841 HCC2688 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.856618 H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GTEX-POYW-1326-SM-48TCG GTEx Tissue Sample Gene Expression Profiles 1.0 0.948003 microtubule organizing center part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.619255 disease of metabolism DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.045135 intermediate stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56618 GSE194396,GSE194429_1_v_0_atrx_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OXRL-1626-SM-2YUMU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1282 Perturb_9972_KD_BCLAF1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.66182 skeletalmuscle BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.29866 NCI-H2126 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.28606 uterus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056674 cell-cell junction GO Cellular Component Annotations 2023 1.0 null Perturb_10003_KD_GPKOW_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.59573 GSE169205_0_v_7_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null ZD-85-ND87_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.350234 GSE184892_7_v_2_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null FGFR3_druginhibition_36_GDS5023 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.78711 hsa-miR-2278 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 ZNF610 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 128.904 hsa-miR-320d TargetScan Predicted Conserved microRNA Targets 1.0 0.257113 terete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21167 GSE221327_4_v_2_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Gene_Name_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BC-54-ON71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.250769 EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCIMY7 DepMap CRISPR Gene Dependency 1.0 2.5969 XA-12-UL84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.301868 IGR-37 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.853275 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.825919 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M6-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE152441,GSE152442_7_v_5_folic acid_human RummaGEO Drug Perturbation Signatures 1.0 null SNU-407 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE80819_0_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null PMC11933697-41467_2025_58216_MOESM8_ESM.xlsx-SD6_ATF3_EV_NS1-SYMBOL_ATF3 Rummagene Transcription Factor Associations 2026 1.0 null esophagus HPA Tissue Gene Expression Profiles 1.0 0.922496 dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.30833 inner SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.853169 intracellular part GO Cellular Component Annotations 2015 1.0 null GATA3-26560356-CHIP-SEQ-TH1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BE-31-XV38_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.31074 CB-30-KN11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.825714 GTEX-QVUS-0006-SM-3GAE8 GTEx Tissue Sample Gene Expression Profiles -1.0 -4.16968 GSE114284_4_v_3_irf1_human RummaGEO Gene Perturbation Signatures -1.0 null GD-82-CS38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.03761 GSE221020,GSE221023_2_v_0_pten_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE86507,GSE86509_0_v_1_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78M-01A-21R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lateral mammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16354 CTCF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intermediate stratum of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47061 Perturb_16965_KD_S100a4_SRP345370 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -13.9266 oculomotor nuclear complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19343 AD-18-XC14_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.65854 Pancreatic adenocarcinoma_PAAD_TCGA-IB-AAUV-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE71385_1_v_0_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null DF-00-BU08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.12097 COLO 205 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.92675 HB-06-WU12_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.86512 BD-90-DK64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.294078 GSE167886_2_v_0_chd7_mouse RummaGEO Gene Perturbation Signatures 1.0 null DA-66-OE69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.66602 hsa-miR-4653-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.121 WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.0039 H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE226091,GSE226092_3_v_1_sall1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PF-59-CY33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.395556 pontine nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.55041 FD-62-ZB67_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.590214 hsa-miR-339-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 496100505_TCx_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.86093 SK-N-DZ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.18151 GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02768 GSE135030_3_v_4_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null Learning Disorders CTD Gene-Disease Associations 1.0 1.14678 hsa-miR-548d-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GSE149264,GSE149267_2_v_1_trp53_mouse RummaGEO Gene Perturbation Signatures -1.0 null Sarcoma_SARC_TCGA-JV-A5VE-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-genes_with_only_SALL4_peaks-Protein-coding_genes_that_show_only_CUT_RUN_peaks_with_2_SALL4_antibodies_and_no_other_antibodies_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-PWOO-0526-SM-2S1Q3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.850296 BD-18-MM33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.363909 POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ED-15-OX47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.352167 Physical disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.104 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null GSE233679_5_v_8_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null outer CP in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0118 Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7402-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-922 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.911523 Agranular insular area, dorsal part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.13512 GTEX-T5JW-0726-SM-4DM6D GTEx Tissue Sample Gene Expression Profiles 1.0 0.925026 15843827-TableS8 GeneSigDB Published Gene Signatures 1.0 null primary motor cortex (area M1, area 4)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10707 Perturb_13280_KO_Ythdf1/Ythdf2/Ythdf3_SRP254797 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 4.0929 H3K9me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Vasculature-lymphatic endothelial cell Tabula Sapiens Gene-Cell Associations 1.0 0.339761 inferior olivary complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.03381 GTEX-NPJ7-0006-SM-3GACR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.93266 hsa-miR-561 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GTEX-RVPV-0526-SM-47JYL GTEx Tissue Sample Gene Expression Profiles 1.0 1.16104 SET2 DepMap CRISPR Gene Dependency 1.0 2.9524 GTEX-WY7C-2126-SM-3NB2R GTEx Tissue Sample Gene Expression Profiles 1.0 1.24749 SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.50012 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IBC 293 DeepCoverMOA Drug Mechanisms of Action 1.0 0.46 RA-27-ST16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.434956 GE-47-OO30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.380723 bonemarrow_6c HPA Tissue Sample Gene Expression Profiles -1.0 -1.12022 GSE185944_2_v_1_pth1r_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of InsCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.34048 cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 BC-01-JL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -5.43293 OLIG2-26023283-AINV15-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-NPJ8-1926-SM-3MJGB GTEx Tissue Sample Gene Expression Profiles 1.0 1.03514 hsa-miR-4708-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55G-0006-SM-2TC6O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51335 ZB-29-GC39_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.592993 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06469 PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_1_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null COLO 792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.51693 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A7DS-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AE-38-LX10_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.286895 GTEX-WZTO-0126-SM-3NM95 GTEx Tissue Sample Gene Expression Profiles 1.0 1.20489 H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-HB-A43Z-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_16793_KD_SPIN1_SRP171066 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.76717 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_53_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_WERI-Rb-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RPMI 8226 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.53518 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE226285_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null CTCF_fibroblast of pedal digit skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PROX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.1037 GTEX-TMMY-1926-SM-4DXUU GTEx Tissue Sample Gene Expression Profiles 1.0 0.896639 DA-33-BM26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.201594 GSE149355_0_v_1_esrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.24782 GSE151612_0_v_2_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null NR4A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.51238 GTEX-U3ZN-2326-SM-3DB7W GTEx Tissue Sample Gene Expression Profiles 1.0 1.23136 ARNT JASPAR Predicted Transcription Factor Targets 1.0 null GSE160001,GSE160670_0_v_2_lapatinib_human RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V3-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE172016_2_v_0_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-SSA3-0005-SM-32QOT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12287 chromosome, subtelomeric region COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.207 HCC1954 CCLE Cell Line Gene Expression Profiles -1.0 -1.89463 HES1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.9258 AGXT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.48732 GTEX-QVJO-1626-SM-2S1QW GTEx Tissue Sample Gene Expression Profiles 1.0 1.37724 CTCF_GM12866_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4922_KD_WTAP_ERP019668 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.84034 GSE208096_1_v_0_progesterone_mouse RummaGEO Drug Perturbation Signatures 1.0 null SNU387 CCLE Cell Line Gene Expression Profiles -1.0 -1.60144 GTEX-XQ8I-0626-SM-4BOPT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.877693 GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles -1.0 -2.44782 Hypertension CTD Gene-Disease Associations 1.0 1.01512 GSE58724_1_v_0_oxymetholone_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE109530,GSE109531_1_v_3_hdac3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-NFK9-0006-SM-3GACS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0641 Perturb_9988_KD_CNOT7_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.58064 digits BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.59179 liver disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.071881 GSE186707_1_v_0_hdac4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE224096_3_v_0_cocaine_human RummaGEO Drug Perturbation Signatures -1.0 null primary auditory cortex (core)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.921085 17660535-TableS4c GeneSigDB Published Gene Signatures 1.0 null Sarcoma_SARC_TCGA-MB-A8JL-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QDVN-0006-SM-48U1R GTEx Tissue Sample Gene Expression Profiles -1.0 -3.23665 carcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052716 Perturb_9311_KD_Trp53_SRP320074 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.55478 EF-99-HJ48_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.466722 intermediate stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.23602 breast cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.059484 GSE139975_3_v_0_rnf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null UA-39-TN76_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.248242 GTEX-T5JW-1626-SM-3GADZ GTEx Tissue Sample Gene Expression Profiles 1.0 2.5987 TBX5-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_CD14-positive monocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EF-01A-11R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Frozen shoulder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.262 GSE179002_2_v_6_caprin1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PSPC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10602 GSE148066,GSE157787_5_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cingulate cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3883 GTEX-QEG4-0226-SM-2S1PY GTEx Tissue Sample Gene Expression Profiles 1.0 1.29333 Primary somatosensory area, mouth Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01381 FF-54-JC89_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208253 CML-T1 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZBTB7A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-N7MS-0007-SM-2D7W1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16692 H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CDC37 Pathway Commons Protein-Protein Interactions 1.0 null Intrinsic component of presynaptic membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.854 GTEX-RM2N-0526-SM-2TF4N GTEx Tissue Sample Gene Expression Profiles 1.0 1.07029 dorsolateral prefrontal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.11721 GSE193993_5_v_6_sstr2_human RummaGEO Gene Perturbation Signatures 1.0 null outer CP in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.844153 Prostate adenocarcinoma_PRAD_TCGA-EJ-7328-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null protein complex COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 Fra-1_KO_GDS5078_402_mouse_Lung GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null FE-10-KQ78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.75958 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046636 Perturb_10001_KD_FMR1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 7.50697 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.857727 CE-04-PX35_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.419041 H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OC-10-FB51_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.305626 Perturb_9963_KD_MTPAP_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.47424 Agranular insular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.77449 GTEX-X585-0002-SM-46MVA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17537 Perturb_10067_KD_EIF3A_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.72025 PMC6257835__F7 PFOCR Pathway Figure Associations 2023 1.0 null GSE148066,GSE157787_11_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null DC-23-UM36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.404682 CTCF_astrocyte of the cerebellum_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null temporal muscle trigeminal motor cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05052 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRSS22 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.72104 ED-05-LQ40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.436652 r9 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.56069 RERF-LC-KJ Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.27636 GSE162892_4_v_2_sox9_human RummaGEO Gene Perturbation Signatures -1.0 null Primary somatosensory area, lower limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.018 GSE190384,GSE190386_0_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null Pericentriolar material COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.961 GSE236280_0_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null DMS53 CCLE Cell Line Gene CNV Profiles 1.0 1.83591 DB-73-BC12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.475084 GSE171572_0_v_2_tp53_human RummaGEO Gene Perturbation Signatures 1.0 null PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Table_S5A_Upregulated_genes_in_tumours_from_DCIS-SOX11_cells_compared_to_DCIS-lacZ_cells_injected_into_mammary_fat_pad_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null FB-98-HM88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.889972 GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.97801 GTEX-R55F-0126-SM-48FCK GTEx Tissue Sample Gene Expression Profiles 1.0 1.04459 HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.86811 CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06606 CALM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05104 CTCF_LNCaP clone FGC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_CD4+ CD25- Th Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null centrosomal GeneRIF Biological Term Annotations 1.0 null Perturb_7681_KD_UPF2_SRP267245 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -4.00121 GSE145915_5_v_4_pcm1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A3/KAW Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04611 anterior orbital gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.93796 Carcinoma in Situ HuGE Navigator Gene-Phenotype Associations 1.0 null GSE254770_0_v_1_sin3b_mouse RummaGEO Gene Perturbation Signatures -1.0 null CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.73878 MVB12A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.41504 H3K9ac_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-RNOR-0126-SM-2TF57 GTEx Tissue Sample Gene Expression Profiles 1.0 1.29789 GSE131798,GSE131804_2_v_0_igf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE189789_0_v_1_oridonin_human RummaGEO Drug Perturbation Signatures 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CQ-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE125014_1_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE223893_4_v_9_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A61W-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null DLD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.10784 catalytic complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043224 UF-85-NE30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.319809 H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE174498,GSE174500_0_v_8_asparaginase_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_fibroblast of upper leg skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3163 TargetScan Predicted Conserved microRNA Targets 1.0 0.303626 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SNU-719 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.4088 TF-77-DW08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.271073 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47X-01A-31R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GLIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.0477 hESC Derived CD184+ Endoderm Cultured Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 0.868654 GSE148200_0_v_5_gemcitabine_human RummaGEO Drug Perturbation Signatures 1.0 null KC-48-OO62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.96364 HS578T Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.16917 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4905-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_401_KD_RNF113A_SRP201913 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 5.31558 Reproductive organ cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.078 PFEIFFER Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.1758 PMC11297914-41389_2024_531_MOESM1_ESM.pdf-178-ZBTB2_ZBTB2 Rummagene Transcription Factor Associations 2026 1.0 null SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.03795 hmc1 HPA Cell Line Gene Expression Profiles 1.0 1.36851 HL-60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.91165 VC-19-YG34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.634717 GTEX-PWN1-2526-SM-48TDS GTEx Tissue Sample Gene Expression Profiles 1.0 1.04527 GA-88-CF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.245096 KYO1 DepMap CRISPR Gene Dependency 1.0 8.42315 PMC7725876-Table_2.xls-Sheet1-Table_2_v1_DEGs_in_the_BESC_were_treated_with_LPS_compared_with_PBS_control_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Uterine Carcinosarcoma_UCS_TCGA-NA-A4R1-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE114232_10_v_6_mavs_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE73561,GSE73563_0_v_1_mef2c_mouse RummaGEO Gene Perturbation Signatures -1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-56-7579-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4974-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YD-49-HM53_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.250187 SKMEL30 CCLE Cell Line Gene Expression Profiles 1.0 1.84349 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060804 Human papillomavirus infection KEGG Pathways 2026 1.0 null GTEX-WYVS-0006-SM-3NMA7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29053 GSE125014_1_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE228894_0_v_1_rnmt_mouse RummaGEO Gene Perturbation Signatures 1.0 null FOXA1_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-53-7813-01A-11R-2170-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell-cell junction GO Cellular Component Annotations 2015 1.0 null GTEX-V1D1-2226-SM-3NMAX GTEx Tissue Sample Gene Expression Profiles 1.0 1.15519 supraoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50258 estradiol_mus musculus_gpl4134_gse23241 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null HDAC6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XYKS-2426-SM-4AT43 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.863258 GTEX-WOFL-0006-SM-3TW8K GTEx Tissue Sample Gene Expression Profiles -1.0 -2.58413 AB-33-EM56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.247748 AA-18-GQ83_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.271532 intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.047296 Lung squamous cell carcinoma_LUSC_TCGA-18-3409-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8303_KD_SRFBP1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 17.031 DF-84-RT50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.607198 GSE210870_0_v_2_snai1_human RummaGEO Gene Perturbation Signatures 1.0 null Perturb_15408_KD_GATA2_SRP043960 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -15.2607 GSE138815,GSE138817_0_v_2_kdm6a_mouse RummaGEO Gene Perturbation Signatures 1.0 null CHST13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50255 GSE231648_1_v_5_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.1517 SUZ12 ChEA Transcription Factor Targets 1.0 null GSE190186,GSE190188_0_v_10_apoe_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.878644 posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.677 nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Arsenic CTD Gene-Chemical Interactions 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7287-01A-11R-2139-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-4276 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 Bladder Urothelial Carcinoma_BLCA_TCGA-XF-A8HG-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE219274,GSE219276_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures 1.0 null PMC10746608-427_2023_709_MOESM5_ESM.xlsx-NR3C1_partners-NR3C1_known_protein_partners_according_to_BioGrid_NR3C1 Rummagene Transcription Factor Associations 2026 1.0 null SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.75568 hsa-miR-761 TargetScan Predicted Conserved microRNA Targets 1.0 0.136254 CTCF_LNCaP clone FGC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_3792_KD_MYC_SRP057613 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.88038 Kinocilium COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.848 H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-548h TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GSE225684_0_v_2_tfap4_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-3614-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.0155 epithelial cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052183 GSE120413,GSE120447_0_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC9195629-Table1.xlsx-Supplementary_Table_1-C-FOS_FOS Rummagene Transcription Factor Associations 2026 1.0 null ZNF682 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 77.2401 17660535-TableS4a GeneSigDB Published Gene Signatures 1.0 null Isocortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.79289 GPR50 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13993 GE-63-WI86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.272685 PHLDA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12513 TA-20-FO62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.316935 RHNO1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03207 GSE213588_9_v_5_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null MA-58-RR04_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.323387 Rootlet TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.565 GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11789 GSE228894_0_v_2_rnmt_mouse RummaGEO Gene Perturbation Signatures 1.0 null AA-52-JS03_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.217706 COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.954511 GTEX-OHPM-2626-SM-33HC5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.960022 ZNF165 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.79975 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.456 orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.16859 plasma membrane GO Cellular Component Annotations 2015 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.050772 EF-62-IO23_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.211646 TD-69-UA90_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.22045 Large latent transforming growth factor-beta complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.859 GTEX-XYKS-1426-SM-4BRUO GTEx Tissue Sample Gene Expression Profiles 1.0 1.31824 AB-30-CR11_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.317156 GTEX-T2IS-0126-SM-4DM6O GTEx Tissue Sample Gene Expression Profiles 1.0 1.56814 GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.938912 GTEX-WH7G-0526-SM-3NMBI GTEx Tissue Sample Gene Expression Profiles 1.0 0.908475 GSE125403_7_v_6_venetoclax_human RummaGEO Drug Perturbation Signatures -1.0 null GSE95386_0_v_1_trim24_human RummaGEO Gene Perturbation Signatures -1.0 null GSE224096_1_v_0_cocaine_human RummaGEO Drug Perturbation Signatures -1.0 null cell part LOCATE Curated Protein Localization Annotations 1.0 null Musculoskeletal system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.575 MRPS14 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.00958 acquired metabolic disease GWASdb SNP-Disease Associations 1.0 0.145131 hsa-miR-4282 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GSE159678_6_v_7_chloroquine_human RummaGEO Drug Perturbation Signatures 1.0 null layer 2 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3883 TE-87-FM14_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.262336 COV644 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.28952 MTF2-20144788-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-OXRK-0226-SM-3NB2G GTEx Tissue Sample Gene Expression Profiles 1.0 1.09017 SNU1214 CCLE Cell Line Gene Expression Profiles 1.0 2.6527 GSE198165,GSE198166_9_v_2_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_7548_Mut_UPF1_SRP298492 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 PMC9248879-supp_gr.275831.121_Supplemental_Table_S2.xlsx-TP53-dependent_proteins-GeneName_TP53 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM12872_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_2_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null NCIH1437_LUNG CCLE Cell Line Proteomics 1.0 2.2479 KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15196 GSE151829,GSE151831_3_v_0_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_14602_KD_PAR1_SRP273320 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.52463 BC-74-QN56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.297336 CC-00-ZO24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.371259 H3K27ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SARS-CoV MA15_Day7-PFU-10^5_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.82549 whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05088 CTCF_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SNMC-1426-SM-2XCFM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02813 GSE155031_6_v_3_dextran_human RummaGEO Drug Perturbation Signatures -1.0 null hepatitis b DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.352659 GTEX-QV44-2026-SM-2S1RD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.84892 H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SK-MEL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.23184 CTCF_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WHSE-0006-SM-3NMBW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3365 CAL148 CCLE Cell Line Gene Expression Profiles 1.0 1.58055 abnormality of cardiovascular system physiology GWASdb SNP-Phenotype Associations 1.0 0.485639 HCC1428 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.69243 RAD18 Pathway Commons Protein-Protein Interactions 1.0 null superficial stratum of OCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56392 GSE216273,GSE216292_0_v_1_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null NMuMg cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.909 VPS33A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07968 GTEX-T6MO-1626-SM-32QOM GTEx Tissue Sample Gene Expression Profiles 1.0 1.23758 GTEX-XQ8I-0006-SM-4BOQ5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.49104 rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.105551 GTEX-WFG7-1126-SM-4LMK3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.866365 Laryngeal cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.738 HDAC2_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MA-31-VM30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.648135 Perturb_2149_KO_Piezo1_SRP226320 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.011 GTEX-WFON-1926-SM-3LK7L GTEx Tissue Sample Gene Expression Profiles 1.0 1.29366 CCDC88A Pathway Commons Protein-Protein Interactions 1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Perturb_6290_OE_ZNF165_SRP390251 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.73635 A4/FUK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.986395 Hmx2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 40.4636 CD-05-PU90_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.259659 CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_GM12866_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PA-75-VL17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.69786 ZIC1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 75.1205 mantle zone of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3883 CTCF_fibroblast of pulmonary artery_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE217405_3_v_2_osimertinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null KIF23 Pathway Commons Protein-Protein Interactions 1.0 null AE-85-LR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.449693 BC-72-DZ30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202907 H3K9me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Ebolavirus(ZEBOV)_5day_Liver_None_GSE57214 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.71527 GSE242083,GSE242098_3_v_5_med1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE160001,GSE160670_3_v_2_lapatinib_human RummaGEO Drug Perturbation Signatures -1.0 null FA-36-VA24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.62411 GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19994 GTEX-X8HC-0006-SM-46MV6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14156 H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 mucosa TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056334 GSE165704_0_v_1_rif1_mouse RummaGEO Gene Perturbation Signatures -1.0 null AE-13-CX28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.216076 FOXA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null WM-266-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.931926 GTEX-TML8-1926-SM-32QOS GTEx Tissue Sample Gene Expression Profiles 1.0 1.62368 Inferior olivary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.01305 MB-15-ZF03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.333923 Perturb_9999_KD_BOP1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.93033 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.463 GD-46-BU97_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.278547 CF-24-KQ98_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.205591 GTEX-X4XY-0006-SM-46MV2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23149 SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null KE-24-RZ94_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.227431 Ethiprole DeepCoverMOA Drug Mechanisms of Action 1.0 0.23 WERIRB1 DepMap CRISPR Gene Dependency 1.0 6.18356 Perturb_6756_KO|KD_UPF3A/UPF3B|UPF1_SRP327782 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.6533 GSE213588_10_v_4_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null Choriocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.851 H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null EPI-1962-1 (PRKD2) NURSA Protein Complexes 1.0 null H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null 496100530_FWM_dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.10446 Organism form TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Perturb_10006_KD_SF3B1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.17085 CB-32-EI69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.40877 Intestinal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.037 TAL1-26923725-CHIP-SEQ-HPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Median preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24824 GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49675 DE-48-HZ49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.211288 Perturb_6585_KO_Clpp_SRP114840 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.94399 GTEX-XQ3S-1126-SM-4BOPK GTEx Tissue Sample Gene Expression Profiles 1.0 0.926416 GSE186112_1_v_0_med23_human RummaGEO Gene Perturbation Signatures 1.0 null PMC7518891-elife-58374-supp1.xlsm-0_585_3D_2days-SOX11_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_GM12867_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inherited metabolic disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.047529 MA-58-RR04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.560096 Medial amygdalar nucleus, posteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41244 GTEX-SJXC-0126-SM-2XCFF GTEx Tissue Sample Gene Expression Profiles 1.0 2.53941 ZNF705B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.05887 COLO 699 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14303 NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.862687 anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.49993 posteroventral (inferior) parietal cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.853798 PMC5637904-PATH-243-193-s016.xlsx-human_up_in_fat_SOX11-Unnamed_7_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-QEG5-0006-SM-2I5FZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7841 IB-33-TE51_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.27876 MF-37-KQ09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.31059 layer 3 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.93694 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.039563 GSE216273,GSE216292_0_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null orbital frontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.845799 medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.05375 layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08996 GSE239688_4_v_1_canagliflozin_human RummaGEO Drug Perturbation Signatures 1.0 null MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.51208 PRKCZ Pathway Commons Protein-Protein Interactions 1.0 null GSE219195_4_v_2_rbm12_human RummaGEO Gene Perturbation Signatures -1.0 null GSE86507,GSE86509_4_v_1_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_42_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null PSMC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17295 PMC8379183-41467_2021_25326_MOESM9_ESM.xlsx-SALL4_unique_peaks-Unnamed_14_SALL4 Rummagene Transcription Factor Associations 2026 1.0 null EGFR_druginhibition_82_GSE27638 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.11384 GTEX-QDVJ-1926-SM-2S1PJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.988974 hsa-miR-1248 TargetScan Predicted Conserved microRNA Targets 1.0 0.90397 Ovariole TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.502 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE145476_2_v_0_hopx_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Brain Cingulate Gyrus Roadmap Epigenomics Histone Modification Site Profiles 1.0 null PF-382 COSMIC Cell Line Gene Mutation Profiles 1.0 null Perturb_14285_OE_YAPS127A_SRP336792 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.34854 BANF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18434 YTHDF2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16276 SARS-CoV_72Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.42433 GTEX-PVOW-1626-SM-48TC9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.975944 Perturb_7462_KD_CHERP_SRP126064 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GSE134191_6_v_5_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null VA-48-RJ44_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.329635 hsa-miR-4271 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GSE151612_4_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Plasma membrane region COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 Hairy cell leukemia cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.771 CA-75-HA22_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.23853 Perturb_9148_KD_KIAA0853_SRP307037 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.80776 Prostate adenocarcinoma_PRAD_TCGA-FC-A8O0-01A-41R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_fibroblast of pedal digit skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MEWO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.595953 GTEX-NFK9-0626-SM-2HMIV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.953917 GSE210101,GSE210114_11_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null H1_Derived_Neuronal_Progenitor_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.885663 IC-72-HR20_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.576493 GSE234637_2_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null EE-03-SG02_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.409464 GTEX-RWS6-2026-SM-2XCB5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.45673 POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-8298-01A-11R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE213588_8_v_2_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null ventrolateral prefrontal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.931169 GSE148066,GSE157787_5_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE213588_9_v_12_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-T6MN-0005-SM-32PLJ GTEx Tissue Sample Gene Expression Profiles -1.0 -2.36408 intermediate stratum of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41694 Acute Myeloid Leukemia_LAML_TCGA-AB-3000-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AE-39-DG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.33147 ventrolateral prefrontal cortex_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.87077 CA-66-YB17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.361125 GTEX-R55C-1726-SM-3GADJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05309 GTEX-RNOR-1226-SM-48FDQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.17383 Perturb_5005_OE_Mnx1_ERP140947 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.75352 CTCF_GM13977_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null LHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.29919 CTCF_foreskin fibroblast_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.961 GSE211177,GSE211178_4_v_3_ets1_mouse RummaGEO Gene Perturbation Signatures 1.0 null DOK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.888442 GSE210101,GSE210114_0_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null hepatobiliary disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.051611 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FD-62-ZB67_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.238662 G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14303 GSE187006_3_v_1_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_Ctr-Nearest_Ensembl_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null AOB, internal plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04105 transverse gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14776 biological_process GO Biological Process Annotations 2015 1.0 null GTEX-XPT6-2026-SM-4B64V GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05041 Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A71E-01A-31R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-VUSG-2326-SM-4KL1U GTEx Tissue Sample Gene Expression Profiles 1.0 1.28816 GTEX-XBED-0006-SM-47JXO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.981324 valproic acid_homo sapiens_gpl6883_gse26940 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-T6MN-0126-SM-32PLP GTEx Tissue Sample Gene Expression Profiles 1.0 2.13972 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cardiovascular system disease GWASdb SNP-Disease Associations 1.0 0.050546 GTEX-OHPK-2026-SM-3MJH7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.887924 FE-64-KC49_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.37154 Perturb_15560_KO_SLFN11_SRP327912 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.45888 GSE211286_1_v_3_tcf12_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-T8EM-0006-SM-3DB71 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24284 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UE-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HT144 DepMap CRISPR Gene Dependency 1.0 7.56913 intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.651 cell junction COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Intermittent explosive disorder DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.402 GSE145311_1_v_3_glutathione_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09095 GSE193258,GSE193259_5_v_3_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null RP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11451 SOX2 ChEA Transcription Factor Targets 1.0 null VC-19-YG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.899195 OB-06-WW76_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.57708 dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.880757 Catenin complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.906 SG in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.68903 Lung adenocarcinoma_LUAD_TCGA-86-7713-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XPT6-0006-SM-4B66Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.99716 layer 2 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.17003 UMRC6 CCLE Cell Line Gene CNV Profiles -1.0 -2.01737 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 GTEX-P4QT-0126-SM-2I3FL GTEx Tissue Sample Gene Expression Profiles 1.0 2.11349 outer portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.02233 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE231799_3_v_4_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null RUNDC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18564 Lung carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.148 H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null cellular_component LOCATE Curated Protein Localization Annotations 1.0 null AB-84-PK04_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231117 GSE112860_0_v_4_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-NPJ8-1626-SM-2HMIY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12529 muscle GTEx Tissue Gene Expression Profiles -1.0 -1.32863 GSE214596,GSE214598_1_v_4_rosiglitazone_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE145915_0_v_2_pcm1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Intrinsic component of synaptic membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.542 SP2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 179.225 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.043208 Prostate adenocarcinoma_PRAD_TCGA-EJ-7330-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_2391_KD_PRKDC_SRP308699 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.03724 GSE149359_2_v_1_asap2_human RummaGEO Gene Perturbation Signatures 1.0 null GSE109530,GSE109531_2_v_3_hdac3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE245270_2_v_5_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null AP1M2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11196 BFTC-905 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15145 molecular_function GO Molecular Function Annotations 2015 1.0 null GSE93309_5_v_3_prmt1_mouse RummaGEO Gene Perturbation Signatures -1.0 null phenotypic abnormality GWASdb SNP-Phenotype Associations 1.0 0.544067 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null VPS11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27147 MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POYW-0006-SM-2XCF4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28919 GSE90552_1_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures 1.0 null tight junction GO Cellular Component Annotations 2025 1.0 null H3K27me3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.973873 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.92642 RBBP9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4596 Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1047 GTEX-X62O-2226-SM-46MW3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.05079 MEL285 DepMap CRISPR Gene Dependency 1.0 3.73701 GSE169590_0_v_1_rptor_human RummaGEO Gene Perturbation Signatures -1.0 null NELFE ENCODE Transcription Factor Targets 1.0 null Anterolateral visual area, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05052 DNAJA2 Pathway Commons Protein-Protein Interactions 1.0 null SK-CO-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.963112 JC-02-ZR15_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.2777 Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.484 COLO 206F Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.5937 HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.24863 GTEX-U3ZM-1526-SM-3DB9D GTEx Tissue Sample Gene Expression Profiles 1.0 0.903416 GSE203308_14_v_3_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RVPU-2226-SM-2XCAQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.52757 SKCO1 CCLE Cell Line Gene CNV Profiles -1.0 -1.83518 GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14376 single-organism cellular process GO Biological Process Annotations 2015 1.0 null GSE216043_11_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures 1.0 null FF-90-JK74_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.484833 H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC8784274__F3 PFOCR Pathway Figure Associations 2024 1.0 null Laryngeal squamous cell carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.86 AC-30-XU83_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.730847 BC-54-ON71_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.76261 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36305 NANOG-16518401-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null hsa-miR-559 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GSE143944_1_v_0_ribociclib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Apical junction complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.321 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE123943_1_v_3_sox1_human RummaGEO Gene Perturbation Signatures 1.0 null anterior amygdaloid area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.20086 Perturb_3455_KO_Mecp2_SRP017936 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.64654 H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Perturb_8243_KD_SRSF9_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.18885 H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Perturb_8072_KD_SNORD126_SRP337208 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -11.447 NFIC JASPAR Predicted Transcription Factor Targets 1.0 null external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07627 TCC-PAN2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11441 superficial stratum of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.16318 GSE151782_4_v_0_aim2_mouse RummaGEO Gene Perturbation Signatures -1.0 null lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.989861 EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hepatitis, Autoimmune_Hepatic Tissue_GSE867 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.65011 Fibrillar collagen trimer COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.508 AE-71-CB15_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.9844 skin_5e HPA Tissue Sample Gene Expression Profiles 1.0 2.09434 PANC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.73357 central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.68263 Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.489 AC-74-ZA35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.45221 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6333-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null GSE119498_0_v_10_setd5_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-NL4W-0006-SM-2I3GH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.00874 Subcortical band heterotopia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.244 ED-71-GA72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.795337 GSE168473_0_v_1_isoniazid_human RummaGEO Drug Perturbation Signatures 1.0 null GSE157555,GSE157556_3_v_7_foxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-01A-11R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE184892_7_v_5_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.972907 Lung squamous cell carcinoma_LUSC_TCGA-37-3789-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-5643-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BC-40-TU13_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.422444 GSE206516,GSE206518_5_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null EGR1 JASPAR Predicted Transcription Factor Targets 1.0 null skin_5f HPA Tissue Sample Gene Expression Profiles 1.0 2.20005 GTEX-QV44-0826-SM-2S1RG GTEx Tissue Sample Gene Expression Profiles 1.0 0.993169 CTCF_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Necrostatin 2 DeepCoverMOA Drug Mechanisms of Action 1.0 0.23 H2AFZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BA-39-HG26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.04945 PSMD6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0933 GTEX-S341-1826-SM-3K2AB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.927835 H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.882437 ME-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03282 KBTBD7 Pathway Commons Protein-Protein Interactions 1.0 null GTEX-QDVN-2426-SM-2S1Q4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.884917 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6961-11A-01R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-37-A5EM-01A-21R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13292 internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Hypertrophy, Left Ventricular_Myocardial tissue_GSE2459 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.38276 CA-48-SW47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.18092 JF-96-HH81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.794711 NCIH446 DepMap CRISPR Gene Dependency 1.0 2.72001 KE-04-OV29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.217775 Perturb_16827_KO_MLL4_SRP058264 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -8.39988 Brain Lower Grade Glioma_LGG_TCGA-HT-7468-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FADS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2181 HF-79-EC41_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.355253 membrane GO Cellular Component Annotations 2015 1.0 null CTV1DM DepMap CRISPR Gene Dependency 1.0 2.24697 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer 5 of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03639 TFAP2E JASPAR Predicted Human Transcription Factor Targets 2025 1.0 83.2397 inner CP in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.906853 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null COLO680N CCLE Cell Line Gene CNV Profiles -1.0 -1.54111 IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -8.72606 posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.859538 GSE234289_3_v_1_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null GSE159446,GSE159449_1_v_0_tunicamycin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE190384,GSE190386_6_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null PMC7518891-elife-58374-supp1.xlsm-0_585-SOX11_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1606 GTEX-U3ZN-0926-SM-4DXTU GTEx Tissue Sample Gene Expression Profiles 1.0 0.932515 layer 5 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14911 GTEX-U3ZH-2026-SM-3DB78 GTEx Tissue Sample Gene Expression Profiles 1.0 1.59537 Sarcoma_SARC_TCGA-HB-A3YV-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RT4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.80632 GSE239578_5_v_7_cxadr_mouse RummaGEO Gene Perturbation Signatures 1.0 null CDKN2AIPNL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.69917 GSE172494_3_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures 1.0 null QA-14-AU91_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.397458 WC-59-RG09_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.213348 serine/threonine protein kinase complex GO Cellular Component Annotations 2023 1.0 null GSE168697_0_v_1_wdr6_mouse RummaGEO Gene Perturbation Signatures -1.0 null ME-31-RM40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.269263 hsa-miR-4650-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 GTEX-QLQ7-0005-SM-2S1QP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51059 Perturb_4215_KO_Ezh2_SRP092451 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.64701 vascular disease GWASdb SNP-Disease Associations 1.0 0.068916 hypertension GWASdb SNP-Disease Associations 1.0 0.569984 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-ZJ-A8QO-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SU.86.86 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.36114 DD-85-WO51_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.227819 FF-06-MO73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.407872 stomach_3b HPA Tissue Sample Gene Expression Profiles -1.0 -0.855047 GSE147210_2_v_5_kmt2d_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_5635_KD_JQ1_SRP142503 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.78454 H3K79me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BF-10-IO69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.356301 EBC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.31017 GTEX-XUW1-0926-SM-4BONX GTEx Tissue Sample Gene Expression Profiles 1.0 1.16504 FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.506842 GTEX-X8HC-0126-SM-4E3JW GTEx Tissue Sample Gene Expression Profiles 1.0 0.943579 Perturb_15574_KD_NUSAP1_SRP074246 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 17.9393 CEBPA-26348894-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null mother GeneRIF Biological Term Annotations 1.0 null Sarcoma_SARC_TCGA-HS-A5N8-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Complement system in neuronal development and plasticity WikiPathways Pathways 2024 1.0 null GSE245270_2_v_4_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null GSE169205_3_v_7_sirt5_human RummaGEO Gene Perturbation Signatures -1.0 null nrf1_22586274_liver_lof_mouse_gpl4134_gse35124 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.004839 PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null FF-86-NH56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.306089 KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.940799 Perturb_15555_KO_SLFN11_SRP327912 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.62131 Cell junction organization Reactome Pathways 2024 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4703-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.37496 H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Unnamed_4_KLF4 Rummagene Transcription Factor Associations 2026 1.0 null SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.76111 CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EA-18-FP00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.68368 PMC9203705-10.1182-2021014723_bloodbld2021014723-suppl2.xlsx-Supp_Table_5-Supplementary_Table_5_List_of_genes_identified_by_WGCNA_corresponding_to_the_CDX2_UBTF_cluster_CDX2 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-46-CK08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.697839 PAR polarity complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 2.053 Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.03828 GTEX-XXEK-1626-SM-4BRUZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.18012 DNAJA1 Pathway Commons Protein-Protein Interactions 1.0 null ZFX-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null Perturb_101_KD_LATS_SRP353750 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 16.3962 layer 1 of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06008 Ovary BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.833028 skin GTEx Tissue Gene Expression Profiles 1.0 1.10517 HB-24-GP45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222899 shell of VMH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11988 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_2008_KO_Arid1a_SRP182831 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -5.14525 DA-10-GX45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.251001 Lung squamous cell carcinoma_LUSC_TCGA-33-4586-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell part GO Cellular Component Annotations 2015 1.0 null GTEX-NPJ8-0007-SM-2D7VX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.86754 GTEX-SJXC-0726-SM-2XCFJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.961591 H3K27me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-UPK5-0006-SM-3GAD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46715 GTEX-V955-0426-SM-3GAEL GTEx Tissue Sample Gene Expression Profiles 1.0 0.84534 hemochromatosis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.482084 H3K27me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10248509-Data_Sheet_6.CSV--GSE58294_DE-genes_AND_GSE22255_DE-Genes_NOT_Autophagy_NOT_GSE66724_DE-Genes_NR4A2 Rummagene Transcription Factor Associations 2026 1.0 null CTCF_fibroblast of lung_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TMMY-0226-SM-33HBA GTEx Tissue Sample Gene Expression Profiles 1.0 1.21598 IGR37 CCLE Cell Line Gene Expression Profiles 1.0 1.9541 GSE70935_3_v_5_cyfip1_human RummaGEO Gene Perturbation Signatures 1.0 null NCIH1092 DepMap CRISPR Gene Dependency 1.0 2.51987 striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.877587 CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_fibroblast of gingiva_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-8120-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GC-04-UF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.427292 Brain Lower Grade Glioma_LGG_TCGA-TQ-A8XE-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of CoPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34683 Centriole COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.318 EC-62-OE64_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.15499 Perturb_9886_KD_ABCF1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.09032 GSE74251_0_v_1_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.34735 GSE235066_7_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GC-74-QF56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.5629 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7925-01A-11R-2156-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BF-79-GG96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.23916 GSE158458_2_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE178255_1_v_4_tlr4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-TSE9-0126-SM-3DB83 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12981 hsa-miR-581 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 cell-cell junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.081073 RUNX1-22412390-EML-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-SIU8-0626-SM-2XCDN GTEx Tissue Sample Gene Expression Profiles 1.0 1.00387 GSE155305_2_v_0_ifitm3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE202284,GSE202289_3_v_4_bmal1_mouse RummaGEO Gene Perturbation Signatures -1.0 null YWHAZ Hub Proteins Protein-Protein Interactions 1.0 null precuneus, right, inferior lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1227 GSE218378_1_v_0_pbx1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RVPV-0006-SM-2TF6Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.32142 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7103-01A-21R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2110 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15196 mRNA_ESRRB_16767105 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null obesity GWASdb SNP-Disease Associations 1.0 0.601579 GTEX-XPVG-2626-SM-4B669 GTEx Tissue Sample Gene Expression Profiles 1.0 1.54727 medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.08167 MA-06-DJ95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.42535 PMC8850648-Table11.xlsx-KS-DEGs_Vs_Liu_et_al_2019-Are_listed_the_239_DEGs_in_common_between_the_current_study_and_the_published_RNAseq_data_of_NRF1_overexpression_in_human_cells_Liu_et_al_2019_NRF1 Rummagene Transcription Factor Associations 2026 1.0 null 888 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.51468 GSE148066,GSE157787_2_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.961 MDA-MB-435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08856 hsa-miR-298 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 GSE190384,GSE190386_3_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null GSE147626_3_v_1_glutathione_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_10034_KD_PUF60_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 16.7296 ZNF544 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04519 DA-69-UN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.201095 H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27me3_Peripheral Blood Mononuclear Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-Q734-0526-SM-2I3EH GTEx Tissue Sample Gene Expression Profiles 1.0 0.83088 superior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.8641 CTCF_fibroblast of lung_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null AC-28-RT00_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.2083 Brain - Hippocampus GTEx Tissue Gene Expression Profiles 2023 1.0 4.12946 WT1-20215353-NEPHRON-PROGENITOR-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CC-03-PW00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.784795 GTEX-OIZG-1326-SM-2HMIQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01354 CTCFL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.7839 TOB1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11769 GSE202434,GSE202438_10_v_14_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.09885 HT-1376 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZBTB7A ENCODE Transcription Factor Targets 1.0 null GSE213588_8_v_4_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null AOB, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17229 lateral part of r6B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54641 NCI-H596 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.39718 PB-09-OE00_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.39409 H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.85235 LF-94-HB11_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.428107 primary motor cortex (area M1, area 4)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.829196 NCOA2_KO_GDS5087_24_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null TCFAP2C-20176728-TROPHOBLAST-STEM-CELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Lymphoma_burkitts(Raji) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.93881 NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_139_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H1930 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20152 HSP90AA1 Pathway Commons Protein-Protein Interactions 1.0 null SP1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 214.156 OCIMY7 CCLE Cell Line Gene CNV Profiles 1.0 1.51042 NFE2L2-20460467-MEF-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-X585-2426-SM-46MW2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16977 Acute Myeloid Leukemia_LAML_TCGA-AB-2956-03A-01T-0740-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QEL4-0626-SM-3GIJM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.855815 GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles -1.0 -0.955524 EPI-2046-1 (CTNNA2) NURSA Protein Complexes 1.0 null EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3444-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_4905_KO_NSUN6_SRP233222 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.3928 CTCF_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Tight junction interactions Reactome Pathways 2014 1.0 null HS695T DepMap CRISPR Gene Dependency 1.0 4.12326 GSE186471_1_v_2_carnosol_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WYBS-1926-SM-3NM8N GTEx Tissue Sample Gene Expression Profiles 1.0 0.864642 RAD21_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SETDB1_02_52 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.60699 PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2 Rummagene Transcription Factor Associations 2026 1.0 null GSE236454,GSE236456_0_v_1_angiotensin ii_mouse RummaGEO Drug Perturbation Signatures 1.0 null GLIS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 81.2712 Perturb_9100_KD_Tfpi_SRP312891 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.69536 TTC642 DepMap CRISPR Gene Dependency 1.0 3.50821 BB-20-UU03_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.512123 YAP1 ChEA Transcription Factor Targets 1.0 null CTCF_fibroblast of skin of abdomen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3133 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 superficial stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21012 H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ZNF549 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 45.08 JC-06-ED36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.507805 RAC1 Hub Proteins Protein-Protein Interactions 1.0 null paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09493 GA-77-MH38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.54532 GTEX-NFK9-1126-SM-3LK78 GTEx Tissue Sample Gene Expression Profiles 1.0 0.980078 GSE256181_1_v_0_etv2_human RummaGEO Gene Perturbation Signatures 1.0 null EE-03-SG02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.265873 Guanosine triphosphate HMDB Metabolites of Enzymes 1.0 null Perturb_6423_KD_LOC646329_SRP220725 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.72907 AD-00-WA10_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.678117 GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.997874 HES5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0116 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null AA-22-UI44_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.230754 Lung squamous cell carcinoma_LUSC_TCGA-56-8082-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_17043_KD_GORASP1_SRP201887 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE168458_1_v_3_disulfiram_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE232786_1_v_0_otud1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE221327_4_v_11_clpp_human RummaGEO Gene Perturbation Signatures 1.0 null TE441T CCLE Cell Line Gene Expression Profiles 1.0 3.39214 e2f1_21245101_mmtv-myc_lof_mouse_gpl8321_gds4094 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.380786 HARA CCLE Cell Line Gene CNV Profiles -1.0 -1.41327 SMC3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null DLX1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03923 BD-69-XG81_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237627 WWC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06084 H3K27me3_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4345-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-75-6214-01A-41R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE171401_1_v_2_adnp_mouse RummaGEO Gene Perturbation Signatures -1.0 null SU-DHL-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.41787 Posterior parietal association areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00075 PMC9992472-41467_2023_36735_MOESM5_ESM.xlsx-SOX11_OE_9h_in_SH-EP-Unnamed_7_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GTEX-S33H-0826-SM-4AD5Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.918554 CE-95-YX02_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.302351 PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_TCGA-GBM-OVOL2_OVOL2 Rummagene Transcription Factor Associations 2026 1.0 null PE01 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.85235 H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XBEW-0006-SM-4AT4E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51241 GTEX-WH7G-2026-SM-3NMBL GTEx Tissue Sample Gene Expression Profiles 1.0 1.2805 SW 480 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.04594 SQSTM1 Pathway Commons Protein-Protein Interactions 1.0 null GSE148657_2_v_1_cd44_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUW1-0005-SM-4BOQ7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.346 GF1B-26923725-CHIP-SEQ-HPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE184210_0_v_3_glucagon_mouse RummaGEO Drug Perturbation Signatures 1.0 null AD-16-HL96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.02649 Primary somatosensory area, trunk Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04587 ventral tuberomammillary nucleus, intermediate part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17568 H3ac_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM19238_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZZ-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null gyrus rectus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.910967 hsa-miR-548n TargetScan Predicted Conserved microRNA Targets 1.0 0.828473 Perturb_7652_KD_RRP40_SRP126942 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -10.9699 HCC1143 CCLE Cell Line Gene CNV Profiles 1.0 1.51479 GTEX-W5WG-1826-SM-4KL2Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.54157 GSE136238_1_v_0_ebf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-888 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.99187 AB-18-YN11_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.62838 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5705-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FD-59-TC81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.310742 GSE118766_2_v_0_ifng_mouse RummaGEO Gene Perturbation Signatures 1.0 null EN COSMIC Cell Line Gene Mutation Profiles 1.0 null KLF15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 170.074 GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles -1.0 -0.986884 thorax TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.251279 SCC4 DepMap CRISPR Gene Dependency 1.0 7.4692 H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null C170 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.91165 H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KARPAS-422 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58057 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PARD3 Pathway Commons Protein-Protein Interactions 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-7630-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null CE-96-GH46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.364399 H3K27me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Autosomal genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.007 ND-68-CU31_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.368956 NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06469 ELP6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19244 FOXP2 ENCODE Transcription Factor Targets 1.0 null GSE119498_2_v_4_setd5_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-V1D1-2026-SM-3GAF4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23396 GSE209598_0_v_3_tgfbr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_GM12873_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null UACC-257 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.19907 Perturb_2095_KD_EIF4A3_SRP226707 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 14.2845 GTEX-XBED-1926-SM-47JYP GTEx Tissue Sample Gene Expression Profiles 1.0 1.25515 GTEX-XOT4-0005-SM-4B64S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.826875 GSE210885_2_v_6_klf4_mouse RummaGEO Gene Perturbation Signatures 1.0 null GA-47-MH68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.241138 Glaucoma_Retina_GSE3554 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.42268 Brain Lower Grade Glioma_LGG_TCGA-P5-A5EZ-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.12489 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.911523 GSE213588_8_v_5_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4843-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null REST ENCODE Transcription Factor Targets 1.0 null RAC1 Pathway Commons Protein-Protein Interactions 1.0 null FD-62-ZB67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.361202 ATP6V1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12517 GTEX-VJYA-1126-SM-3GIJU GTEx Tissue Sample Gene Expression Profiles 1.0 1.83058 GSE167886_2_v_1_chd7_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCIH522 CCLE Cell Line Gene CNV Profiles 1.0 1.55815 OCILY3 CCLE Cell Line Gene Expression Profiles 1.0 1.4122 mantle zone of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23688 artery disease GWASdb SNP-Disease Associations 1.0 0.096548 HCC1395 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00232 GSE122711_1_v_0_mpc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SUZ12-20075857-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE122711_2_v_3_mpc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8204-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE198254_1_v_0_metformin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-W5X1-2326-SM-3GIL6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.960532 Prostate adenocarcinoma_PRAD_TCGA-HC-8262-11A-01R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.99338 Perturb_9647_KO_MESP2_SRP153047 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.58616 FA-88-II68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.490479 SIN3A ENCODE Transcription Factor Targets 1.0 null CTCF_fibroblast of lung_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TOP3B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.25161 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE139966_4_v_3_figla_mouse RummaGEO Gene Perturbation Signatures 1.0 null vagina GTEx Tissue Gene Expression Profiles 1.0 0.883773 Lung adenocarcinoma_LUAD_TCGA-55-6968-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE171177,GSE171181_1_v_0_e7107_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-410 TargetScan Predicted Conserved microRNA Targets 1.0 0.283838 GTEX-RN64-0626-SM-2TC5V GTEx Tissue Sample Gene Expression Profiles 1.0 0.859517 CTCF_choroid plexus epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135030_11_v_6_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE190384,GSE190386_2_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-X4EP-0005-SM-3P5ZE GTEx Tissue Sample Gene Expression Profiles -1.0 -2.34325 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7406-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TP53-23651856-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CYP2S1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.33007 Foxl2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.7456 KU1919 CCLE Cell Line Gene Expression Profiles 1.0 1.40581 GSE233679_5_v_3_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null uterine endometrium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.215534 GSE77108_6_v_7_saha_human RummaGEO Drug Perturbation Signatures 1.0 null GSE254770_3_v_1_sin3b_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_104_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4341-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE184892_7_v_3_trehalose_human RummaGEO Drug Perturbation Signatures 1.0 null Lung disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.121 GSE235066_4_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null Triangular nucleus of septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07752 primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.883057 QF-71-QI30_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.546154 GSE142210_4_v_10_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-548ak TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 IC-76-JU42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.04543 NCIH1385 CCLE Cell Line Gene CNV Profiles 1.0 1.51402 H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null DF-00-BU08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.318798 496100592_FWM_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.61083 RPRML CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50076 GTEX-OOBJ-1626-SM-2I3F7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.956188 AC-36-TL21_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.391684 KNS-62 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03034 H3K4me1_Neurosphere Cultured Cells Cortex Derived Roadmap Epigenomics Histone Modification Site Profiles 1.0 null suboptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.70423 PMC11324510-41587_2023_1949_MOESM3_ESM.xlsx-Supplementary_Table6-Supplementary_Table_6_TP53_pathway_genes_list_TP53 Rummagene Transcription Factor Associations 2026 1.0 null RAD21_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BAG5 Pathway Commons Protein-Protein Interactions 1.0 null Megalencephalic leukoencephalopathy with subcortical cysts DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.277 CTCF_foreskin fibroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 C33A DepMap CRISPR Gene Dependency 1.0 3.62028 GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833564 Perturb_11409_KD_ESRP1/ESRP2_SRP191570 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.11875 GTEX-U8XE-1126-SM-3DB8W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.959649 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4766-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-3613-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 hsa-miR-153 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 GSE244072_10_v_3_tfeb_mouse RummaGEO Gene Perturbation Signatures -1.0 null intermediate stratum of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24904 Perturb_8180_KD_STIP1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.50945 Subceruleus nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04587 HDAC2_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GA-59-RW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.70947 GTEX-XV7Q-2526-SM-4BRV9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.855247 GTEX-UPIC-1626-SM-4IHKT GTEx Tissue Sample Gene Expression Profiles 1.0 1.39825 breast adenocarcinoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.095306 GTEX-QV44-1926-SM-2S1RF GTEx Tissue Sample Gene Expression Profiles 1.0 1.4401 internal female genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052107 STK36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.49366 layer 3 of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.86899 624 MEL Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.02642 KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW 620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.864987 carcinoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051363 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null mRNA_SOX9_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null S0-EE-Y737_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.433988 SCN1B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.27126 hsa-miR-4731-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.875351 H3K27me3_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AA-52-JS03_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.399039 Field CA1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05528 cell junction assembly GO Biological Process Annotations 2015 1.0 null A-427 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.14303 OF-05-CB18_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 3.32144 Perturb_2150_KO_Piezo1/Piezo2_SRP226320 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.00973 BHLHE40 ENCODE Transcription Factor Targets 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CDC42 Hub Proteins Protein-Protein Interactions 1.0 null mantle zone of r9BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61773 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QLQ7-1626-SM-2S1R8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13453 Brain - Caudate (basal ganglia) GTEx Tissue Gene Expression Profiles 2023 1.0 1.34062 CB-62-TB77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.368912 OGFRL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.61361 GSE213588_10_v_13_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null LTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41289 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A5QV-01A-22R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZD-18-MI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.244123 HES2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.0456 BB-44-SX65_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.940844 pallium Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.018 H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.972063 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4IQ-01A-12R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lymphatic edema_Skin tissue_GSE4333 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 3.08132 GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles -1.0 -0.963334 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.986703 MON DepMap CRISPR Gene Dependency 1.0 4.38454 POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE188870,GSE188871_0_v_2_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE139016_0_v_1_disulfiram_human RummaGEO Drug Perturbation Signatures 1.0 null AA-22-UI44_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.266548 Lung squamous cell carcinoma_LUSC_TCGA-56-5898-01A-11R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH28 DepMap CRISPR Gene Dependency 1.0 4.60734 GSE120612_4_v_1_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-R45C-1226-SM-48FEE GTEx Tissue Sample Gene Expression Profiles 1.0 0.990983 POLR2A_lung_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE190384,GSE190386_1_v_4_fulvestrant_human RummaGEO Drug Perturbation Signatures 1.0 null report GeneRIF Biological Term Annotations 1.0 null GTEX-OHPK-2526-SM-3MJH9 GTEx Tissue Sample Gene Expression Profiles 1.0 0.89648 GSE180200,GSE180201_2_v_0_qpctl_mouse RummaGEO Gene Perturbation Signatures -1.0 null km3 HPA Cell Line Gene Expression Profiles -1.0 -1.17043 occluding junction COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.16233 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IG-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE166783_8_v_2_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null GSE231648_4_v_2_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-642a TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GSE220629_0_v_1_foxp3_human RummaGEO Gene Perturbation Signatures -1.0 null GSE242333_0_v_1_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null MT-CO3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.45999 Perturb_4236_KD_Cnot7_SRP091584 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.17116 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE44157,GSE44163_3_v_0_nr6a1_mouse RummaGEO Gene Perturbation Signatures -1.0 null DMS454 CCLE Cell Line Gene CNV Profiles 1.0 1.41317 Perturb_14128_KD_AKR1B1_SRP400403 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.54847 H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.38875 terminal hypothalamus (rostral hypothalamus) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.08156 GSE230744,GSE237803_0_v_2_hira_human RummaGEO Gene Perturbation Signatures 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null SCS214 DepMap CRISPR Gene Dependency 1.0 3.53263 GTEX-OIZG-0726-SM-33HBL GTEx Tissue Sample Gene Expression Profiles 1.0 2.03178 NCI-H1648 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.892087 EB-19-SM10_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.271686 NFE2L2-20460467-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE60837_0_v_3_bcl9_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE149123,GSE149128_2_v_0_cdk7_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC1187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.23504 GSE175787_11_v_7_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null EPI-2416-1 (HMGB3) NURSA Protein Complexes 1.0 null AE-85-KE62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.383252 CTCF_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_9970_KD_WDR43_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.39724 GSE118816_0_v_3_myo1c_human RummaGEO Gene Perturbation Signatures 1.0 null JHOS4 CCLE Cell Line Gene CNV Profiles 1.0 2.50189 GSE188870,GSE188871_4_v_5_kat7_mouse RummaGEO Gene Perturbation Signatures 1.0 null outer CP in subgenual (subcallosal) cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.09143 Brain Lower Grade Glioma_LGG_TCGA-HT-A619-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF454 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 296.873 GSE122378_0_v_1_carmil3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE118077_7_v_2_sprr5_human RummaGEO Gene Perturbation Signatures 1.0 null TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SERHL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18921 GSE217452_3_v_0_docetaxel_human RummaGEO Drug Perturbation Signatures 1.0 null outer CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.32906 GSE172016_2_v_5_paclitaxel_human RummaGEO Drug Perturbation Signatures -1.0 null CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cell junction COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 GTEX-T8EM-1326-SM-3DB7G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02485 GTEX-WFG8-2426-SM-3GILL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04937 H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null NCOA2_KO_GSE41558_19_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Chromosomal disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.127 BL9429 (C7orf20) NURSA Protein Complexes 1.0 null BA-39-OX47_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.311459 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5183-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7SE-0726-SM-2XCD7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.99606 BICR31 CCLE Cell Line Gene CNV Profiles -1.0 -1.97381 GSE206870,GSE206872_0_v_2_ascl1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE104022_3_v_7_tamoxifen_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE74251_0_v_3_decitabine_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X5EB-1926-SM-4E3IW GTEx Tissue Sample Gene Expression Profiles 1.0 1.77071 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_9500_KI_Trp53_SRP201382 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.49055 H3K27me3_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_10029_KD_CELF1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.732 GSE132369,GSE132371_5_v_0_cccp_human RummaGEO Drug Perturbation Signatures 1.0 null UQCR10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.01397 GTEX-OXRK-1826-SM-2HMJE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05422 XE-18-BC97_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.421635 CTCF_epithelial cell of proximal tubule_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE206729_2_v_0_trps1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE142210_3_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.02625 CE-18-AP85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.349358 KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02433 GSE158197_6_v_10_egfr_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE111247_2_v_1_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null GSE86507,GSE86509_7_v_10_hoxb7_mouse RummaGEO Gene Perturbation Signatures 1.0 null Phox/Bem1p InterPro Predicted Protein Domain Annotations 1.0 null CF-48-QD87_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.63117 Anchoring junction COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 4.0 Transient neonatal diabetes mellitus DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.174 BD-49-MD69_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.607539 TFAP2C-20629094-MCF7-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-2600-01A-01R-0851-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE223893_1_v_10_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null BMP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27079 GTEX-WEY5-2326-SM-3GIKK GTEx Tissue Sample Gene Expression Profiles 1.0 1.07803 UBC Pathway Commons Protein-Protein Interactions 1.0 null GSE198165,GSE198166_9_v_4_zfp266_mouse RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37341 Cervical Intraepithelial Neoplasia HuGE Navigator Gene-Phenotype Associations 1.0 null OB-17-DQ74_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.28294 GSE71385_1_v_2_cdk8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-WVLH-0006-SM-3MJF7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.46864 BHLHE40_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE241701_1_v_0_daxx_mouse RummaGEO Gene Perturbation Signatures 1.0 null GD-66-XE49_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.0367 BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03079 QA-34-PH05_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.439906 HC-76-SY22_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.33314 HC-74-HM63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.898194 GTEX-U8T8-0005-SM-3DB8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21035 H2AFZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.944837 GTEX-WYVS-1626-SM-3NM9R GTEx Tissue Sample Gene Expression Profiles 1.0 1.50084 GB-64-HC34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.692066 Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EJ-01A-11R-A155-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular process GO Biological Process Annotations 2015 1.0 null precuneus, right, superior lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.04635 r9 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41654 GTEX-OXRP-0006-SM-2I3FN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.60595 fusiform gyrus, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.3348 GSE135514_8_v_9_dasatinib_human RummaGEO Drug Perturbation Signatures -1.0 null Intermediodorsal nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30672 layer 3 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45956 outer CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.41824 GSE91015_0_v_1_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null gracile nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.27935 GTEX-WYJK-0126-SM-3NMAB GTEx Tissue Sample Gene Expression Profiles 1.0 1.77537 PAR polarity complex GO Cellular Component Annotations 2025 1.0 null cell cycle GO Biological Process Annotations 2015 1.0 null GTEX-R55E-0126-SM-2TC5Y GTEx Tissue Sample Gene Expression Profiles 1.0 1.23639 GSE234340_4_v_2_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Extravillous trophoblast cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.76 IPC298 CCLE Cell Line Gene Expression Profiles 1.0 1.52058 G361 CCLE Cell Line Gene Expression Profiles 1.0 1.85773 GSE210580_0_v_12_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_MCF-7_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null GC-69-JF03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.333161 GTEX-T2YK-0005-SM-32QOV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13415 medial trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03415 cytoskeletal part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.08995 vitamin c_mus musculus_gpl6246_gse19378 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R53T-1826-SM-3GIJX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.911396 CE-03-YQ91_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.258898 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE193177_1_v_2_st266_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OXRK-0626-SM-2HMJ5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.834825 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RU72-0926-SM-2TF6B GTEx Tissue Sample Gene Expression Profiles 1.0 1.38252 ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09717 SHP77_LUNG CCLE Cell Line Proteomics 1.0 11.646 H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Perturb_10005_KD_METAP2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 4.55589 GTEX-R55G-2326-SM-2TC61 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03086 SUM102PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.865825 superficial stratum of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07825 GSE135352_0_v_3_napabucasin_human RummaGEO Drug Perturbation Signatures 1.0 null ME-31-RM40_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.205649 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1048 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.991769 ZNF320 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 312.939 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.871647 T84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.26465 GTEX-REY6-1326-SM-48FDO GTEx Tissue Sample Gene Expression Profiles 1.0 0.991095 GSE102505_1_v_0_tunicamycin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-RVPV-1226-SM-2TF73 GTEx Tissue Sample Gene Expression Profiles 1.0 0.978158 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.40061 HCC1954 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.696587 GSE137325_2_v_0_copanlisib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-IB-7890-01A-12R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE210770_0_v_1_foxp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null S0-EE-Y6LH_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.211122 lateral medullary reticular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01014 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_2723_KD_HOTAIR_SRP172688 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.33864 GSE70935_2_v_0_cyfip1_human RummaGEO Gene Perturbation Signatures -1.0 null CA46 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.08687 Developmental disorder of mental health DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.043 GSE210580_0_v_11_rag2_mouse RummaGEO Gene Perturbation Signatures -1.0 null OVTOKO DepMap CRISPR Gene Dependency 1.0 4.52591 Perturb_9969_KD_WDR3_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.29244 GTEX-WZTO-0006-SM-3NM9T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73936 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JA-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null hsa-miR-590-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.49473 CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HL60 CCLE Cell Line Gene CNV Profiles 1.0 1.39859 MEIS1-26923725-CHIP-SEQ-HEMOGENIC-ENDOTHELIUM-MOUSE ChEA Transcription Factor Targets 2022 1.0 null hsa-miR-5096 TargetScan Predicted Conserved microRNA Targets 1.0 0.136254 FD-79-TC61_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.243644 hsa-miR-548aj TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 FA-43-XS35_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212896 Perturb_1208_KO_Zbtb7a_SRP302435 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.19416 LA-44-KW22_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.550232 NE-00-JZ19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.430456 Perturb_12518_KD_TRA2B_SRP221583 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 9.47008 GSE175787_11_v_9_rhoc_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-1276 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 TFAP2A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 176.869 Perturb_7464_KD_U2SURP_SRP126064 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -11.6546 ISHIKAWAHERAKLIO02ER DepMap CRISPR Gene Dependency 1.0 2.51881 GSE234289_5_v_2_rfx6_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.59022 CEBPZ_02_176 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.61626 EPI-1970-1 (MAP1LC3A) NURSA Protein Complexes 1.0 null GTEX-WVLH-0626-SM-3MJG7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.903045 Perturb_15557_KO_SLFN11_SRP327912 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 3.65094 GTEX-XUJ4-2626-SM-4BOQ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.842004 NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.05663 pro-B-lymphocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.354 central medullary reticular group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.922917 sublayer 6a of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.00932 GSE178255_2_v_4_tlr4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE111247_11_v_13_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null EZH2_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A84O-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ML349 DeepCoverMOA Drug Mechanisms of Action -1.0 -0.26 GSE231648_4_v_5_lsm14b_mouse RummaGEO Gene Perturbation Signatures -1.0 null YMB-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.911523 OCI-LY-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.31498 Contractile vacuolar membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.991 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-7055-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null dorsal pallium/isocortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.72621 SG in primary somatosensory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.91503 GTEX-REY6-0005-SM-2TF54 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.53062 gigantocellular reticular nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.45869 GSE149359_2_v_0_asap2_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-O5YT-0126-SM-48TBW GTEx Tissue Sample Gene Expression Profiles 1.0 1.20781 CTCF_astrocyte of the cerebellum_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4078-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OVCAR-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.29381 BGC823 CCLE Cell Line Gene CNV Profiles -1.0 -1.64086 CA-68-KG29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.222266 EA-18-FP00_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.586962 QE-79-XO29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.833987 GSE202434,GSE202438_13_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.961 AB-33-EM56_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.907595 r5 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38121 Type II spiral ganglion neuron_Brain_Mouse CellMarker Gene-Cell Type Associations 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5884-11A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_8231_KD_PRPF4_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.68484 shell part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.79801 CC-04-WK34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.454401 hsa-miR-371b-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GSE148066,GSE157787_8_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null SNU-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.982974 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.748 YY1 ENCODE Transcription Factor Targets 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial gray layer of SC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1164 GSE213588_8_v_6_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WK11-0926-SM-3NMAU GTEx Tissue Sample Gene Expression Profiles 1.0 0.833729 GTEX-QDT8-0006-SM-32PL3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37358 pancreas_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.0993 GSE220914_1_v_0_zdhhc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4B-Up_Nanog_KD-Unnamed_1_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE117212,GSE117214_0_v_1_zbtb1_human RummaGEO Gene Perturbation Signatures -1.0 null FF-34-KW62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.205394 Axon guidance KEGG Pathways 2026 1.0 null GSE65617_5_v_1_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE149621_2_v_1_olaparib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE158502,GSE158506_3_v_0_fat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null cell-cell junction COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Perturb_9816_KD_ARID5B_SRP103740 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.31242 cytosol GO Cellular Component Annotations 2015 1.0 null Perturb_10030_KD_EIF4G2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.47726 PUR1 MotifMap Predicted Transcription Factor Targets 1.0 null PMC6257835__F7 PFOCR Pathway Figure Associations 2024 1.0 null GSE228413_4_v_1_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null layer 2 of PCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.51991 Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4151-01A-01R-1188-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Stalk cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.702 PNMA2 Pathway Commons Protein-Protein Interactions 1.0 null MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55911 GTEX-W5X1-2526-SM-3GILC GTEx Tissue Sample Gene Expression Profiles 1.0 1.31893 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE164463_4_v_1_pax6_mouse RummaGEO Gene Perturbation Signatures 1.0 null S0-EE-WJKI_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.341217 PMC2263127-pone.0001816.s002.xls-Terms_with_Genes_E2F3_up_Bild-Title_E2F3 Rummagene Transcription Factor Associations 2026 1.0 null PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_60_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null protein binding GO Molecular Function Annotations 2015 1.0 null GSE142210_9_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null osteoclasts BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.18438 GTEX-XOTO-0726-SM-4B659 GTEx Tissue Sample Gene Expression Profiles 1.0 1.57324 NCIH209 CCLE Cell Line Gene CNV Profiles 1.0 1.4502 principal sensory nucleus of trigeminal nerve, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.12181 binding GO Molecular Function Annotations 2015 1.0 null EGR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 87.8655 Perturb_8120_KD_SF1_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.53902 ventrolateral prefrontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.858519 GSE206516,GSE206518_0_v_7_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null FA-63-WI26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.473041 H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA3_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null DA-20-VR86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 6.11073 Primary hematopoietic stem cells G-CSF-mobilized Female RO_01536 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -2.07906 POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCFL5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.1 H3K27me3_kidney epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LOXL2_KD_GSE35600_688_human_MDA-MB-231 cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null GSE243720_1_v_0_cyclophosphamide_human RummaGEO Drug Perturbation Signatures 1.0 null SUZ12 ENCODE Transcription Factor Targets 1.0 null Lung adenocarcinoma_LUAD_TCGA-49-4494-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9894241-pnas.2211429119.sd05.xlsx-G1_REST-Dataset_S5_Differentially_expressed_genes_in_G1-G8_REST Rummagene Transcription Factor Associations 2026 1.0 null CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO ChEA Transcription Factor Targets 2022 1.0 null GA-28-SS67_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.858546 GLIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 48.1227 hsa-miR-4804-3p TargetScan Predicted Conserved microRNA Targets 1.0 1.45615 JHUEM7 DepMap CRISPR Gene Dependency 1.0 2.57955 Sarcoma_SARC_TCGA-IW-A3M4-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE223893_11_v_10_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S4Q7-0006-SM-3K2AT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44865 superficial stratum of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18974 KELLY Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68475 GSE175787_5_v_6_rhoc_human RummaGEO Gene Perturbation Signatures -1.0 null GSE183113_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-U412-0426-SM-3DB9O GTEx Tissue Sample Gene Expression Profiles 1.0 1.24801 hsa-miR-4325 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.2992 POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WH7G-0005-SM-3NMBX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.78226 RT-112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.952663 Lung squamous cell carcinoma_LUSC_TCGA-77-7463-01A-11R-2045-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE125219,GSE125221_4_v_2_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null HA-22-CY42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.431564 PANC1 CCLE Cell Line Gene CNV Profiles 1.0 2.05907 ZNF417 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 41.1662 H3K4me1_Brain Inferior Temporal Lobe Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GSE234289_4_v_1_rfx6_human RummaGEO Gene Perturbation Signatures -1.0 null GC-46-AX49_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232356 CTCF_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null AB-18-YN11_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.680176 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.922084 H4C3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.18251 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.970377 Brain Lower Grade Glioma_LGG_TCGA-DU-6397-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.57851 Lung non-small cell carcinoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.118 GSE203308_7_v_5_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null PAR polarity complex GO Cellular Component Annotations 2023 1.0 null GTEX-XYKS-0005-SM-4BRUD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05013 ND-39-PO34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.289319 first GeneRIF Biological Term Annotations 1.0 null Perturb_296_OE_ERG/MYC_SRP069177 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.87905 BC-13-OQ01_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.286576 RREB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 215.0 FOXA2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-73-QS80_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.55546 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null DA-81-VY50_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.395276 496100494_HIP_no dementia_TBI_100+_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.66404 PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_Pre-Pro-B-Cells_ChIP-seq_TCF3 Rummagene Transcription Factor Associations 2026 1.0 null PMC7371429-elife-53600-supp2.xlsx-annotated_MEIS1_in_B13ko-M1-Nearest_Ensembl_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null layer 4 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18503 Neonatal diabetes DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.148 EGR3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 98.9346 caudal portion of VFC (area 44) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.32729 Perturb_3530_KD_circCDKN2BAS1_SRP252917 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.5725 GSE176008_4_v_1_azacitidine_human RummaGEO Drug Perturbation Signatures -1.0 null HS888T CCLE Cell Line Gene Expression Profiles -1.0 -1.50591 USP39 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04014 GSE234340_4_v_7_muc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Perturb_10075_KD_AQR_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 20.0 GSE131649_4_v_9_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null Perturb_14579_KO_LINC00901_SRP312185 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -6.15299 arcuate nucleus of medulla, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.23165 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZU-06A-12R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.237908 H2AFZ_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE223334_3_v_0_bcl11b_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE156115_2_v_1_igf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Ebolavirus(ZEBOV)_1day_Spleen_None_GSE57214 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.64416 MARK3 Pathway Commons Protein-Protein Interactions 1.0 null PMC9950457-mmc3.xlsx-AP2A_binding_sites_GRHL2_KO-LRRC32_GRHL2 Rummagene Transcription Factor Associations 2026 1.0 null inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44341 CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cellular component organization GO Biological Process Annotations 2015 1.0 null Olanzapine DeepCoverMOA Drug Mechanisms of Action -1.0 -0.24 KP2 CCLE Cell Line Gene CNV Profiles -1.0 -1.61626 H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AF-99-HA02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.504842 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE163884_1_v_0_sumo2_human RummaGEO Gene Perturbation Signatures 1.0 null mantle zone of OCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55269 polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.54959 GSE223008_7_v_8_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC2263127-pone.0001816.s001.xls-E2F3_up_Bild-Symbol_E2F3 Rummagene Transcription Factor Associations 2026 1.0 null MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.12243 GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.829208 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1891 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HMY-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.839291 sirolimus_mus musculus_gpl1261_gse5332 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.30406 H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 UF-27-HS98_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 2.19768 GTEX-XQ3S-1526-SM-4BOOC GTEx Tissue Sample Gene Expression Profiles 1.0 1.71461 PD-70-VS77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.663704 KLF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 88.0314 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EZH2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JB-23-ZE86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.539208 hsa-miR-3973 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GTEX-X4EP-0126-SM-3P5YV GTEx Tissue Sample Gene Expression Profiles 1.0 1.19442 Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.29657 cingulate gyrus, retrosplenial part, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.32034 dentate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03294 TE-15-RO34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.437503 GTEX-XUJ4-2426-SM-4BOO3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16874 Angioblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.551 intermediate stratum of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17684 GTEX-QCQG-1726-SM-3GIJ9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.92388 Prostate adenocarcinoma_PRAD_TCGA-HC-7745-11A-01R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r2 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.3306 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Aster COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.991 Perturb_9991_KD_ILF2_SRP013565 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.65049 CTCF_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Growth cone membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.57 GSE116580_0_v_1_smug1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE160001,GSE160670_1_v_2_lapatinib_human RummaGEO Drug Perturbation Signatures -1.0 null layer 2 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06488 GSE154767_4_v_5_adam10_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23992 GTEX-TSE9-0005-SM-4DXUF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33444 pre-B-lymphocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.387 PMC10746608-427_2023_709_MOESM4_ESM.xlsx-SOX2_targets_enrichment-Unnamed_45_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930417 esophagus_5a HPA Tissue Sample Gene Expression Profiles 1.0 0.967438 GSE193177_1_v_0_st266_mouse RummaGEO Drug Perturbation Signatures -1.0 null GTEX-NL3H-0008-SM-4E3HU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.833921 female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065497 KLF7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 149.349 GA-88-CF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.25313 H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE135030_11_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GF-37-MB64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.337823 establishment or maintenance of apical/basal cell polarity GO Biological Process Annotations 2023 1.0 null MEL-HO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.72641 KA-29-AB08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 3.4453 Perturb_17614_OE_FOXP2_SRP225889 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 16.3869 H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cellular component organization or biogenesis GO Biological Process Annotations 2015 1.0 null GSE253041_1_v_0_ramp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null DC-51-WE27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.550059 FOXA1_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.04297 GTEX-X3Y1-2026-SM-3P5YM GTEx Tissue Sample Gene Expression Profiles 1.0 0.903969 DA-17-XI26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.2265 BD-69-GX17_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.586082 mantle zone of r9BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28995 FOXA1_T47D_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3656 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.921135 CE-15-YU05_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.394274 KLF10 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 240.447 centriole COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.658619 GSE226316_4_v_2_tead2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S7SF-1426-SM-4AT5A GTEx Tissue Sample Gene Expression Profiles 1.0 0.859419 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE153189_1_v_3_interferon gamma_mouse RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IH-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE192663_3_v_2_acly_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-RU72-0726-SM-46MUW GTEx Tissue Sample Gene Expression Profiles 1.0 1.11009 r6 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19245 DC-23-UM36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210334 H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Zonula adherens COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.339 Asi complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.74 GTEX-WEY5-0826-SM-4LMIH GTEx Tissue Sample Gene Expression Profiles 1.0 0.829049 BD-49-MD69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.284675 AA-45-AA67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.423642 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.91511 primary auditory cortex (core)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.03555 NCI-H209 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.49389 FAM222B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43542 GTEX-OHPM-1626-SM-2HMK4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00794 COLO668 CCLE Cell Line Gene CNV Profiles 1.0 1.66978 H3K27me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X4EO-2926-SM-4E3JH GTEx Tissue Sample Gene Expression Profiles 1.0 1.41668 PC-18-VX23_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.318208 hsa-miR-503 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Prostate adenocarcinoma_PRAD_TCGA-CH-5768-11A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 16207381-Table1Sb GeneSigDB Published Gene Signatures 1.0 null UMC-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.09985 GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01392 BE-82-TS38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.212261 GTEX-WYBS-0626-SM-3NMAS GTEx Tissue Sample Gene Expression Profiles 1.0 1.27667 GSE228413_0_v_3_mavs_mouse RummaGEO Gene Perturbation Signatures 1.0 null Prostate adenocarcinoma_PRAD_TCGA-CH-5767-11B-01R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null temporal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.07648 CTCF_GM12874_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-X2-A95T-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24383 intracellular membrane-bounded organelle GO Cellular Component Annotations 2023 1.0 null GSE102505_1_v_2_tunicamycin_human RummaGEO Drug Perturbation Signatures 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-HE-7130-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AK3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13375 Lung adenocarcinoma_LUAD_TCGA-64-5774-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BA-39-HG26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.818204 GSE168401_1_v_0_harmine_human RummaGEO Drug Perturbation Signatures 1.0 null orbital frontal cortex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29839 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV4-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SN8G-0126-SM-32PLI GTEx Tissue Sample Gene Expression Profiles 1.0 1.11723 GB-94-XG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.610151 Apical plasma membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 3.0 GSE188774_1_v_0_hkdc1_human RummaGEO Gene Perturbation Signatures -1.0 null orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.826949 OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.5707 GTEX-VJWN-0005-SM-3GIKF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.66709 abducens motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.48163 CF-65-GU65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.617803 Genetic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.245 H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BC-14-CG34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.310966 primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.970756 GSE245270_1_v_4_isoproterenol_human RummaGEO Drug Perturbation Signatures -1.0 null PMC9203705-bloodBLD2021014723-suppl2.xlsx-Supp_Table_5-Supplementary_Table_5_List_of_genes_identified_by_WGCNA_corresponding_to_the_CDX2_UBTF_cluster_CDX2 Rummagene Transcription Factor Associations 2026 1.0 null mRNA_NR5A2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null viral infectious disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.047125 cell division GO Biological Process Annotations 2015 1.0 null Tight junction interactions Reactome Pathways 2024 1.0 null GTEX-TML8-1826-SM-32QOR GTEx Tissue Sample Gene Expression Profiles -1.0 -0.864313 GTEX-OOBJ-2626-SM-2I3F6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.06464 GTEX-XBED-0126-SM-47JY7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.957595 H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC7518891-elife-58374-supp1.xlsm-Common_in_3D_0_585-SOX11_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null GC-04-UF36_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.17956 RKN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.917884 RAPGEF2 Pathway Commons Protein-Protein Interactions 1.0 null GSE180185_9_v_8_setbp1_human RummaGEO Gene Perturbation Signatures -1.0 null WE-43-PZ45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 3.16709 primary motor cortex (area M1, area 4)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01309 MAZ ENCODE Transcription Factor Targets 1.0 null GSE213588_8_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE213588_10_v_6_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PX3G-2626-SM-2I3EG GTEx Tissue Sample Gene Expression Profiles 1.0 0.861483 H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE120612_7_v_1_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-133a TargetScan Predicted Conserved microRNA Targets 1.0 0.082179 H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC9013128-NIHMS1795992-supplement-4.xlsx-SKmel147_ARID2_KO_Downregulated-Gene_name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0398 CTCF_WERI-Rb-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null parasolitary nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.53989 Anterior cell cortex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.037 CREB3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.58456 GTEX-WFON-2326-SM-3LK7M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.39485 H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RL DepMap CRISPR Gene Dependency 1.0 2.18694 SAP130 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.08974 GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.834304 Colon - Transverse GTEx Tissue Gene Expression Profiles 2023 1.0 1.88376 Hodgkin lymphoma cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.949 GSE77108_4_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null single-organism process GO Biological Process Annotations 2015 1.0 null GSE216273,GSE216292_14_v_6_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null r10 part of the inferior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.23128 GSE148658_1_v_0_six6_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XMK1-0005-SM-4B665 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.4241 PMC12079334-ADVS-12-2501734-s002.pdf-178-ENSG00000179981_TSHZ1 Rummagene Transcription Factor Associations 2026 1.0 null Perturb_12949_KD_HOXBLINC_SRP149346 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -3.03167 Proteinuria CTD Gene-Disease Associations 1.0 1.0894 Supraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43869 WT1 ChEA Transcription Factor Targets 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null GTEX-S7SF-1626-SM-3K2AY GTEx Tissue Sample Gene Expression Profiles 1.0 1.89377 496100523_HIP_possible Alzheimer's disease_no TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 6.34057 HHIPL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32831 central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.24297 Mo-B cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.801 cell part LOCATE Predicted Protein Localization Annotations 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HI-7169-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-77-8128-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE122215,GSE122217_0_v_2_peg10_mouse RummaGEO Gene Perturbation Signatures -1.0 null TNFSF13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38908 IGR37 CCLE Cell Line Gene CNV Profiles 1.0 1.42778 GSE188870,GSE188871_1_v_2_kat7_mouse RummaGEO Gene Perturbation Signatures -1.0 null organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046911 BE-79-QU25_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.869406 BA-86-AL61_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.201656 GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1602 Sarcoma_SARC_TCGA-VT-A80G-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Posterior parietal association areas, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06008 Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6X2-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BL70 DepMap CRISPR Gene Dependency 1.0 2.72756 Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6133-11A-01R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BC-00-YH62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.487812 GTEX-PW2O-0006-SM-2I3DV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37722 hsa-miR-129-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 intermediate stratum of r2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48953 H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE261563_9_v_8_atrx_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-X88G-0006-SM-47JX5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21276 GSE213588_10_v_2_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null layer 3 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.86899 GSE108675_3_v_0_slc1a4_mouse RummaGEO Gene Perturbation Signatures 1.0 null bonemarrow BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.83696 GTEX-RWS6-0005-SM-2XCAN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95113 ZNF551 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.09811 SLC38A4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22506 layer 3 of CCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44999 FOXD4L4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1493 Pancreatic adenocarcinoma_PAAD_TCGA-IB-7893-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE217405_3_v_2_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06574 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RAD21_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null REX1BD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29223 Acute Myeloid Leukemia_LAML_TCGA-AB-2872-03A-01T-0735-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HD-51-KD29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.36209 Basal part of cell COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.111 Foxo1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.378 PPM1N CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4198