association	dataset	threshold value	standardized value
GTEX-WOFM-1726-SM-3MJFA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859964
Interrenal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.54
GSE142232,GSE142234_0_v_2_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE135312_1_v_2_bmpr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10082046-41467_2023_37049_MOESM6_ESM.xlsx-Sheet1-Supplementary_Data_3_Genes_downregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_7222_KO_RING1/RNF2_SRP321650	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MZT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56037
SCN7A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00601549
PMC5352183-oncotarget-08-624-s009.xlsx-Table_S20-1_indicates_that_the_gene_is_both_a_TP53-MW_and_a_TP53-MSN_gene_in_the_correponding_cancer_and_0_indicates_not_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
8653_TAF12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.74782
SA-32-CC58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253663
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GRIK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00718591
CI-1040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60826
8826_TEX10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.33113
IRF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00702746
Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNCA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00772167
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
5900_NUP62_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.218
BRD-K50204028_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Skin-cd4-positive helper t cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.164575
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13359
VZ in subcallosal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23879
shell of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.91358
BRD-K16485616_mocetinostat_HCC515_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ventral lateral nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05893
Atrophy	CTD Gene-Disease Associations	1.0	1.79369
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02226
BRD-K15341710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01925
superficial stratum of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.48711
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.26549
peptidase inhibitor activity	GO Molecular Function Annotations 2023	1.0	null
GSE210580_0_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRCA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00449376
BRD-K05236810_Luteolin_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.358
MCF7_TGX-221_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0133778
hippocampus (hippocampal formation)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.940335
GTEX-S4UY-0426-SM-3K2AF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
att-20 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.29669
SLC6A12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00720202
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.245
response to stimulus	GO Biological Process Annotations 2015	1.0	null
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H4K20me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HL60	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.908734
Frontotemporal dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.518
MRPL19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00745671
Cellular bud	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.065
7471_RPL39_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.58495
BRD-K81418486_vorinostat_AGS_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
organelle	GO Cellular Component Annotations 2015	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-5899-01A-11R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE161170,GSE161268_1_v_3_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POR_DELETION_GDS1093_240_mouse_Liver from male 3 month old	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
lateral ventricle	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
JA-79-II25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.296591
Internode	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.069
polymorphism	GeneRIF Biological Term Annotations	1.0	null
ELMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00691555
BRD-K81418486_vorinostat_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Anteroventral periventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14699
GSE100863,GSE100864_2_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206870,GSE206872_3_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.576
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5753
kidney_b	HPA Tissue Sample Gene Expression Profiles	1.0	1.36691
BRD-A77467113_-666_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
decreased anxiety-related response	MPO Gene-Phenotype Associations	1.0	null
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052133
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
MYC	ENCODE Transcription Factor Targets	1.0	null
BB-20-UU03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.416504
6854_PSMB6_P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.86921
ALDH3B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563694
BRD-K60219430_serdemetan_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UACC257	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.33332
Thyroid cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.697
547_ARRB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.65684
PBK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00825079
Dorsal part of the lateral geniculate complex	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20744
LOX-IMVI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.94629
Infundibulum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5185-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ1-1426-SM-4GICK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1386
Medial preoptic nucleus, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38838
BA-46-YF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.7541
GSE129241_3_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLAIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.57737
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
GTEX-X585-0011-R2B-SM-46MVF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23333
MMP27	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590957
PancreaticIslet	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.57816
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Hmx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.6001
XE-69-AT35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.04756
TUBA8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571587
BRD-K87748094	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38131
Median nucleus of thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.272
PMC7455079-jciinsight-5-140380-s227.xlsx-Supp_Table_9-Supplemental_Table_9_Limma_DE_Analysis_of_HC_AA_to_EA_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
DMS-114	GDSC Cell Line Gene Expression Profiles	1.0	1.58444
periventricular stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24115
INSM1_lack of the seven N-terminal amino acids_GDS5066_404_mouse_pituitary glands	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
SUPHD1	CCLE Cell Line Gene Expression Profiles	1.0	1.48077
BRD-A39646320_H7270_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NKX2-5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00699709
PMC11961801-12672_2025_2262_MOESM2_ESM.xlsx-Sheet_1-WGCNA_AND_DEGs_NOT_CSGs_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23984367_S1040_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DAZL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0058708
nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.311377
GSE189653,GSE203344_4_v_3_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-Symbol_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.10119
BRD-K68433511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61651
snoutepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.03884
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.915524
FD-20-OG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.651995
NCI-H226Br cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.069
ATF2_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
BRD-K22957824	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47232
RAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00848105
SUZ12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2988_FBL_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.4404
CTCF_kidney_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.771
8317_SPAG7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.89585
NF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00617275
BRD-K81418486_vorinostat_NCIH508_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PDSS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00597249
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
7441_RPL17_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.49681
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.289938
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.605709
psn1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.606
BRD-K60460488_PZ0013_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A39646320_H7270_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.974192
renal cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.304279
7480_RPL8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.42175
spironolactone-1380	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_13734_OE_YAP1_SRP333272	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.89344
BIN67	DepMap CRISPR Gene Dependency	1.0	2.32253
CDK14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520729
CA-48-SW47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221171
Abnormal Behavior	DisGeNET Gene-Phenotype Associations	1.0	null
decreased vertical activity	MGI Mouse Phenotype Associations 2023	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.14053
Acute Kidney Injury	CTD Gene-Disease Associations	1.0	1.12357
GB-94-XG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30684
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CL-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985015
BRD-K29713418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23107
GSE148252_5_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K04704273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07853
GSE216274,GSE216292_4_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80V-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WM35	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.88358
HEATR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21724
GTEX-V955-2626-SM-3NM9F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10357
BRD-K98876398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.26884
BRD-A67788537_Salermide_HT29_24.0_h_120.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.14845
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05681
NDUFAB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00383136
GSE229973_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K15779027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23351
Mesothelioma_MESO_TCGA-SC-A6LN-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DOR 13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.8645
GSE196104,GSE196106_2_v_0_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242555_1_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X585-0011-R1B-SM-46MVE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54852
6962_PWP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08297
BRD-K81418486_vorinostat_HT29_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EP300_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
abnormal eye morphology	MGI Mouse Phenotype Associations 2023	1.0	null
vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE218580_1_v_5_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.875
GTEX-RVPV-0011-R3A-SM-2TF63	GTEx Tissue Sample Gene Expression Profiles	1.0	0.966029
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCIH1385	CCLE Cell Line Gene Expression Profiles	1.0	2.6004
AOB, mitral cell layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.12272
Subiculum, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.27522
TSHR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00705905
JC-67-FV32_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.328846
6874_PSMD6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.27958
DKMG	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67818
BRD-K53903639_480743.cdx_HA1E_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
supraoptic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.298524
PAPOLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41334
Cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.163
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
1351_CCT7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.2357
pancreatic islet	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.181531
BRD-K65597286	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07779
1610_CIAPIN1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01369
GSE109285_5_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.872563
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.928443
SNU308	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49638
ETS2_KD_GSE62168_258_mouse_mouse trophoblast stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
RACK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97069
HINFP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44602
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20599
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.977
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.1406
CTCF_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K43387144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4399
BRD-A19500257_geldanamycin_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K82395301_ST4066738_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MMP26	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00567887
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.925584
brain ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.139068
GTEX-WL46-0011-R6A-SM-3LK6X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58782
BRD-K86797399_pracinostat_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.26558
Rectum adenocarcinoma_READ_TCGA-CL-5917-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9687_UTP6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12464
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.989056
RAD21_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CA-68-KG29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234926
AE-52-FP96_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221692
HNF4A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.71088
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.54932
OC-71-BZ81_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.286643
CFAP46	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00670986
5488_NCAPD3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.46566
GSE214514_1_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Rmz	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.983
9606_UQCC2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.0552
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K12502280_TG101348_NCIH596_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pc3	HPA Cell Line Gene Expression Profiles	1.0	0.88224
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SUCS-1826-SM-32PM1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861489
GSE210580_0_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8605_SURF6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31146
NOP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.28476
PMC7412812-13059_2020_2115_MOESM11_ESM.xlsx-Overlap-Upregulated_in_SERBP1_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
KNS60	CCLE Cell Line Gene CNV Profiles	1.0	1.32782
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07324
tuberomammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70446
medial tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6041
BRD-K43068349_AMG 9810_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pancreatic_Islets	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.15781
BRD-K94018786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20083
BRD-K82928847_rocilinostat_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
tau	GeneRIF Biological Term Annotations	1.0	null
H3K27me3_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM12873_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pregnenolone-2856	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_3H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5504
Brain Lower Grade Glioma_LGG_TCGA-RY-A840-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD63	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00987967
EE-03-SG02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.694478
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posteroventral (inferior) parietal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08146
A549_Dacinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125446
Perturb_4668_KO_Wdr5/Trp53_SRP324834	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.00555
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.60928
BRD-K86797399_pracinostat_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K59571728	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26869
BRD-K57821544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3171
3446_GNL3L_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.76224
peripheral nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.075649
1011_C18ORF21_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.87862
GTEX-PSDG-0526-SM-2S1OH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
hsa-miR-663	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
ethoxyquin-3421	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K97359891	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70777
ZFP36L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00759004
negative regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
STH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00567347
ventrolateral prefrontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12421
CD55	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00421952
MC4R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00891283
GTEX-RVPU-2326-SM-2TF6R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Perturb_5192_KO_Nanog_SRP116119	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.78202
cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
BRD-K92428232_GSK-461364_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A553-01A-12R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.14223
MYC_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.78248
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.8645
PMC8185471-mmc4.xlsx-D4-DEGs_between_SOX15_KO_DPs_and_WT_DPs_cells_at_day_4_padj_0_05_Log2FoldChange_0_5_SOX15_KO_WT_or_Log2FoldChange_-0_5_SOX15_KO_WT_SOX15	Rummagene Transcription Factor Associations 2026	1.0	null
CDK20	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00800335
CC-61-HH09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.370643
GSE146982_4_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_retinal pigment epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0011-R6B-SM-46MWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23868
DUSP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00499788
Paramedian lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1906
Prostate adenocarcinoma_PRAD_TCGA-G9-6379-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00670143
2114_DDX27_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06067
NRF1	ENCODE Transcription Factor Targets	1.0	null
7499_RPS11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.81673
TUBB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00619582
cytoplasmic part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
BRD-K19066553	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02136
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	20.7701
GSE119978,GSE180930_2_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RNOR-2426-SM-48FDY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.88181
UGDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69612
AE-05-CB45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.714036
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE202434,GSE202438_10_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-15-VA57_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257842
dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.61866
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.742501
FIH_Deficiency_GDS3769_511_mouse_Immortalized embryonic fibroblasts	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831312
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WL46-0011-R1A-SM-3LK6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61657
SOX2-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE77108_4_v_1_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K00418890	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17259
Anterior cingulate area, dorsal part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02445
RBMS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00691838
beta-escin-2194	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.53018
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.385
18223198-TableS3	GeneSigDB Published Gene Signatures	1.0	null
GSE197686,GSE197688_2_v_0_arid1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OHPN-0011-R3A-SM-2I5FC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861565
GTEX-NL3H-0011-R2a-SM-2I3GG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05343
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
AB-92-LS83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338767
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
CRCGN009_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06925
GTEX-S7SE-0011-R4A-SM-2XCDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884745
BRD-K11437379	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03727
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K09250623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.05977
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.386428
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25051
BRD-K81035073	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27713
celecoxib-377	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XUZC-2126-SM-4BRW8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
TBK1_knockdown_53_GSE17643	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.46805
BRD-K86923998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0698
peptide	GeneRIF Biological Term Annotations	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SP-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2218	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.773242
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05833
Perturb_16499_KO_ZFP36L1_SRP373359	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_4289_KO_Klf5_SRP374413	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K11662217	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77117
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03194
BRD-K90356496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25807
UFSP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23443
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2009	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93416
paraventricular nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.73475
GSE153867_6_v_4_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
vacuole	LOCATE Predicted Protein Localization Annotations	1.0	null
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.99336
medial mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.99758
CNTN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543468
cerebrospinal fluid	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
LD-39-FL02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.278263
Laryngeal cartilage	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
BB-44-SX65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.709163
CTCF_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nodulus (X), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.25597
diethylcarbamazine-2394	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K16468319	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42275
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
LU-165	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.59519
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
6853_PSMB5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.03489
RAD21_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2238_DLD_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02624
Brain Lower Grade Glioma_LGG_TCGA-RY-A83Y-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5154_KO_Dcr_SRP038929	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.0124
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1485
BRD-K83355732_7611991_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-Q2-A5QZ-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-7980-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J9-A52E-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DEDD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00633897
EIF2B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2084
4116_INCENP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21697
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Wholebrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.12218
CTCF_MCF-7_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE106661,GSE106665_2_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-J4-A67L-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
714_AURKA_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.33956
H3K4me1_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A36630025_-666_HA1E_24.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
7538_RPS8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.55026
HCC1954	CCLE Cell Line Gene CNV Profiles	1.0	1.40815
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.33679
BRD-K78748401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91437
IL18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00657878
fipexide-1560	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06968
8396_SRBD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01298
ACTH-secreting pituitary adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.255
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
BRD-K71486304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55563
Pancreatic islet cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.636
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1163
BRD-K82217056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.27852
BB-20-UU03_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346906
renal cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.336704
BRD-A33711280_Metixene hydrochloride_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ILDR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00519007
medial mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01543
182_AGBL5_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.29721
inner SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.990092
MAPK9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00455683
CRCGN008_HEPG2_24H:A12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14715
PHLDB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.88702
NCIH522	CCLE Cell Line Gene Expression Profiles	1.0	1.36305
cerebrospinal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.581218
Adenoid Cystic Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K93537437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2474
BC-84-BQ58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360715
Lung adenocarcinoma_LUAD_TCGA-44-8120-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.857066
BRD-K79376287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.19421
BRD-A13122391_16-HYDROXYTRIPTOLIDE_PL21_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K11581306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11566
EIF2S3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35991
BRD-K09367542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30536
SPATA2L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572793
BRD-A39996500_radicicol_HA1E_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K69840642_HDAC6 inhibitor ISOX_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
2535_EIF2B1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03405
BRD-K26251149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25017
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70O-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5188_KO_Xpo5_SRP109172	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-12.5233
BRD-K85513726	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44532
Neuronal dense core vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.619
CELA2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0110611
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.85834
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-FOXA1_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC10111863-supp_gad.350269.122_Supplemental_Paun350269_FileS3.xlsx-A_ASCL1-regulated_DGE-geneID_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.96644
FC-20-EQ58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.0958
PMC8387919-mmc2.xlsx-ST6_NEUROG3-KO_downreg-Supplemental_Table_6_Genes_downregulated_in_NEUROG3-_-_hESC_line_differentiated_to_pancreatic_endocrine_progenitors_d13_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE120216_3_v_0_cbfb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tanycyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.655
LEFTY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00389373
LRRC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516118
CF-24-KQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.734002
GTEX-WL46-0011-R7A-SM-3LK7X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33257
CTCF_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7444_RPL19_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19086
G120	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.49306
telencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.428018
cell projection part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.062187
RD-64-KA33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.3656
Prestwick-665-2186	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
putatively	GeneRIF Biological Term Annotations	1.0	null
Esrrg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.3087
ELF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K67448189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00094
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.001513
BRD-K43435656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0799
AA-23-FM46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.682412
Hypanthium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.735
BRD-K74963702	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3453
WM3772F	DepMap CRISPR Gene Dependency	1.0	2.79396
BRD-K01606969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70482
1843_CPSF4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07676
cytoplasmic membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.590973
MAP3K12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00607896
GTEX-XMD1-0011-R3B-SM-4AT5R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08314
U251	BioGPS Cell Line Gene Expression Profiles	-1.0	-0.853337
SLC2A4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40109
GTEX-V955-1126-SM-4JBH3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04733
Uterine Carcinosarcoma_UCS_TCGA-N9-A4PZ-01A-22R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAP4K3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.97446
PTGFR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00725958
DC-23-UM36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.270246
AB-85-YK41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.676656
ZNF263_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482172
BRD-K32231853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32603
BRD-K68118416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78825
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.10023
BRD-A76490030_K784-3131_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_15377_KD_DAXX_SRP058098	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
ED-43-XF39_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230292
GSE179002_2_v_6_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mRNA_KDM5B_22020125	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
stratum radiatum of caudal CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.985503
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.111
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
AF-12-IW93_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211292
H3K27me3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RPL11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0108313
FD-59-TC81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.623688
7055_RAC1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.34532
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.689021
icSARS CoV_12Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.21595
GTEX-X4XX-0011-R1B-SM-3P622	GTEx Tissue Sample Gene Expression Profiles	1.0	0.947657
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969334
PGR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522307
cisplatin_homo sapiens_gds3910	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PLAGL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00789795
ENTHD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00427913
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201111
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21678
7504_RPS15_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25961
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A57G-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K63919349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04214
BRD-K23292451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38767
neuropeptide signaling pathway	GO Biological Process Annotations 2015	1.0	null
GSE154074_1_v_0_bleomycin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TUBA3C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00509345
oxprenolol-6145	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.61473
BC-75-FA82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246499
PMC12178829-mmc4.xlsx-Sheet_4-MEG3-KD_Up-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH2227	CCLE Cell Line Gene Expression Profiles	1.0	3.28067
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.966755
tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.83727
Diabetes Mellitus	DisGeNET Gene-Disease Associations	1.0	null
OB inner plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03777
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5E6-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6886_PSMG3_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.69375
KB-78-BE93_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2756
BRD-K08431704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46778
Oligodendrocyte_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
8633_SYS1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24861
GTEX-T5JC-0226-SM-32PMA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850603
GSE261563_2_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
18172295-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K64670467_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K56234278	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39436
GTEX-X261-0011-R10B-SM-4E3JT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19053
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.61346
MCF7_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165905
CDCA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23171
SMC3_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-8397-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_1_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
MCF7_AT9283_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117724
PMC3879300-pone.0084292.s002.xlsx-SPD_dataset-Gene_symbol_HOXD13	Rummagene Transcription Factor Associations 2026	1.0	null
CLDN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00728805
trans-golgi network	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Periventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35908
terete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.28898
Substance Withdrawal Syndrome	CTD Gene-Disease Associations	1.0	1.07163
BRD-A62184259_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23085
OB-17-DQ74_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.14075
PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3A-Down_Dpy30_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC7918644-LSA-2020-00974_TableS2.xlsx-5_SAd2_BD_D-GATA3_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_9658_KD_SKIDA1_SRP306591	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.5483
erythromycin-2010	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K42995703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72073
GTEX-WWYW-0011-R5A-SM-3NB3E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1873
GSE196104,GSE196106_2_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE94814_1_v_0_reck_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Anther	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.476
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NNT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00275815
OB-17-DQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.726582
PMC2263127-pone.0001816.s001.xls-E2F3_up_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPB_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver Diseases	CTD Gene-Disease Associations	1.0	1.85485
MEC1	DepMap CRISPR Gene Dependency	1.0	2.41861
GTEX-WEY5-0426-SM-3GIKT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.6235
GSE206870,GSE206872_1_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K29301364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36075
IVD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00502366
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.452812
emboliform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44786
CTCF	ENCODE Transcription Factor Targets	1.0	null
ChIP_H3K27me3_20682450_humanESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MAP1LC3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00983446
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.83562
GABA-ergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.006
body wall	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.149484
CTCF_CH12.LX_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4XX-0011-R5A-SM-46MWN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825511
transport vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.595593
JAK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00419332
NDUFA13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00640743
NDUFA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00631344
NCIH1355	CCLE Cell Line Gene CNV Profiles	1.0	1.32834
BRD-K49303291	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45642
Inflorescence apex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.661
GSE93674_1_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MFM-223	COSMIC Cell Line Gene CNV Profiles	1.0	2.15687
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.06577
BHLHE40	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00340968
BRD-K92700781	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71716
primary auditory cortex (core)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09696
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18053
BRD-K81418486_vorinostat_H1299_6.0_h_11.1000003815_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-Q2AG-0011-R4A-SM-2HMKA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27543
BRD-K78015598	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06816
Perturb_4524_KO_Phc3_ERP112796	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.62345
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4512-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XMD1-0011-R6A-SM-4AT5K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76418
LRP8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654402
GTEX-NFK9-0526-SM-2YUNL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994977
Perturb_13848_KO_RET_ERP126468	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
CDK12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00657333
BRD-K42435237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44116
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
CD300LD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00786179
BRD-K26214026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71961
BLTP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00530345
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0302
pancreatic beta cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.196296
JE-22-JR20_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228018
LD-69-ZV56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.308483
ZNF417	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03622
ILF2_02_88	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.61234
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
medial part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.35044
BRD-K12502280_TG-101348_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.043
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NDUFB7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00911361
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pancreas-pancreatic delta cell	Tabula Sapiens Gene-Cell Associations	1.0	1.30694
BRD-K05228434	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00897
BRD-K22377875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62056
BRD-K76748254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30862
TE-15-RO34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252579
BRD-K88485670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87212
GTEX-XUW1-0726-SM-4BOP5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K92817986_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE190384,GSE190386_0_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
PFKFB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00635
GTEX-S32W-0626-SM-2XCBG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12805
nucleotide	GeneRIF Biological Term Annotations	1.0	null
TGFB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00661876
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.498749
6747_PRIM1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11276
BRD-K53903639_480743.cdx_HT29_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Large_Intestine-paneth cell of epithelium of large intestine	Tabula Sapiens Gene-Cell Associations	1.0	0.887264
GSE130437_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.305
BRD-K28932578	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2795
GTEX-RVPV-0226-SM-2TF6W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897113
BRD-K75081836_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NSDHL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0041856
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
levetiracetam_rattus norvegicus_gpl1355_brainstem_gds1864	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04137
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.889338
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A4FC-06A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02975
BRD-K51275565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15907
BRD-K06009608_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K34907403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33577
paraventricular nucleus, rostral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.07808
BRD-K64642496_-666_PC3_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Coronary artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
BRD-K54256913_MK-1775_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DG-75	GDSC Cell Line Gene Expression Profiles	-1.0	-1.53513
NT5C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09917
GTEX-S341-0226-SM-2XCAX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
rostral paraventricular nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32707
NCAPG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00400249
PLAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593703
BRD-K96623405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10847
Lung adenocarcinoma_LUAD_TCGA-62-A46P-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE181959_3_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A94377914_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SPN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00902698
BRD-K91701654_70970_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nicergoline-1374	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-R55E-2726-SM-48FCX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.4169
MARK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00953057
H3K27me3_cardiac mesoderm_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.19115
BRD-K45307863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.962
EGR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.5576
mammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18438
BRD-A57594599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3575
biological regulation	GO Biological Process Annotations 2015	1.0	null
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.673232
SHISAL2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0114473
GTEX-UTHO-0011-R5A-SM-3GIJD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917181
9428_TUBGCP5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03045
Lung adenocarcinoma_LUAD_TCGA-69-7973-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.667516
SCIMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0055467
GSE190384,GSE190386_1_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
diethylstilbestrol_rattus norvegicus_gpl1355_copenhagen_gds2913	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XOTO-0011-R6B-SM-4B65X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60815
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
EOMES-20176728-TSCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE235066_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DC-84-GJ21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.5486
ASPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00669391
Bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.382
HLC1	CCLE Cell Line Gene Expression Profiles	1.0	2.21685
BRD-K25097691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91364
solitary nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22401
BRD-A36630025_-666_MCF7_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IL36RN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00624341
BRD-K91623615_ABT-751_NCIH596_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE195559_0_v_9_notch1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5707-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
peptidase inhibitor activity	GO Molecular Function Annotations 2015	1.0	null
WD-62-UB45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324381
PCSK1	Pathway Commons Protein-Protein Interactions	1.0	null
S100A13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00294163
1347_CCT3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.33364
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00407053
Hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.493
Cortical layer of collagen and cuticulin-based cuticle extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.959
PMC10313451-NIHMS1821833-supplement-Supplementary_Material.pdf-45-ATF4_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF449	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.524
BRD-K81473043_-666_SW480_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00672
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ED-71-GA72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291298
hindbrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.78231
BRD-K63068307_ZSTK-474_HME1_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_4954_KO_Ubn2_ERP125291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.1567
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.432586
GTEX-X4EP-3226-SM-3P5YR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.70405
GSE190384,GSE190386_2_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pituicyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.594
SNU626	CCLE Cell Line Gene Expression Profiles	1.0	1.41574
GTEX-WZTO-0011-R8A-SM-4E3II	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62412
CTCF_HepG2_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14109347_LY2603618_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
REST_PFSK-1_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.09164
MCF7_UNC0379_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.011755
BRD-K43496057	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13586
BRD-K45350681	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02712
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
response to extracellular stimulus	GO Biological Process Annotations 2015	1.0	null
BRD-K86930074_S1017_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K14875480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27386
CRCGN016_MCF10A.TP53.M_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2188
GSE240258_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CBX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00605869
clozapine-6988	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00672
BRD-A47144777_DIHYDRO-7-DESACETYLDEOXYGEDUNIN_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K49507197	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75507
BRD-K97701319_1602-1352_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DGAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00849909
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.4102
GSE198165,GSE198166_9_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Posterior complex of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19899
SLC35C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00706
alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.622967
MCF10F	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.10257
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FM3A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.788
identifies	GeneRIF Biological Term Annotations	1.0	null
BB-87-SF89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204013
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6795-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
C22orf39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36971
8710_TBC1D1_ENST00000261439.4	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20069
1702_CMTR2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.19962
BRD-K60905563	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32645
reticular nucleus of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03577
ELOF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00656428
GSE169263_1_v_0_armc5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MAP4K1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496803
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PLEKHO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00526514
Perturb_4567_KD_Smc1a_SRP172038	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.26182
GTEX-QMR6-0011-R6A-SM-32PKP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.897443
TGW	GDSC Cell Line Gene Expression Profiles	1.0	1.83836
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4519_OE_Zfp708_SRP186171	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.04697
CB-87-RB49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.681078
Primary somatosensory area, upper limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.87876
GSE144231_4_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Stipule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.354
BRD-K64606589_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0161
CCL4L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00567905
lytic vacuole	LOCATE Predicted Protein Localization Annotations	1.0	null
7500_RPS12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.16346
Pancreas-pancreatic alpha cell	Tabula Sapiens Gene-Cell Associations	1.0	2.24461
Neostriatum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.169
1915_CSTF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14214
GTEX-WWYW-3126-SM-3NB39	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13439
MED1_OE_GDS4846_11_human_LNCaP prostate cancer cell	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K78062244_STOCK1N-27488_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE111247_11_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE189834,GSE189836_1_v_0_brd4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.59941
Muscle-cd4-positive, alpha-beta t cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.164575
BRD-K99529078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3493
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.76551
GTEX-QVJO-0011-R6A-SM-2S1QN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999795
choroid plexus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.214576
SLC2A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00541656
USPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86245
RPL37A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00887194
mantle zone of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.00107
E2A_KO_GDS5084_401_mouse_DN2 thymocytes	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.12945
MYBL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.512
GSE239844_7_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.33556
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
SPHK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13569
CXCL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00706352
PMC3226433-1756-8935-4-20-S1.XLS-Table_S4_Myc_KD_gene_exp_change-Genes_up-regulated_in_Myc_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K81418486_vorinostat_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A2M	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547686
BRD-K40452322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21926
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.532462
kidney	GTEx Tissue Gene Expression Profiles	1.0	0.969037
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.5013
Petiole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.615
cytoplasmic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.586361
ALAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00531775
ATF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.4101
TTC549	DepMap CRISPR Gene Dependency	1.0	4.47656
Labellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.291
FC-64-QJ96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292459
PSMB5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04734
QA-58-CX23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.261654
Ubisch body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.407
PMC11511861-41420_2024_2216_MOESM2_ESM.xlsx-GSEA_siYAPsiTAZ-SITAZ_UP__MYC_EZH2_H3K27M3BOUND_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
Pancreatic islet cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.682
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRKDC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00750544
alzheimers	GeneRIF Biological Term Annotations	1.0	null
Whole Blood	GTEx Tissue Gene Expression Profiles 2023	1.0	2.19419
CCL19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00759417
PMC7617064-EMS151900-supplement-Figure_7_Source_Data.xlsx-HLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE238018_1_v_5_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AKT1_knockout_212_GSE39699	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	0.958245
STS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00411321
COG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.103
GTEX-XBEC-0008-SM-4AT3X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
CRCGN015_HEPG2_48H:F04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02456
GTEX-X4XX-0011-R8B-SM-46MWM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58108
BRD-K93624320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09328
Pons	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.059
ADCK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0081551
Cerebral peduncle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.029
BD-69-GX17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272237
amyloid plaque	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.305722
4949_MED26_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.54429
FGFR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06838
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.651805
Endocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.705
brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.18591
PMC6379364-41598_2018_37489_MOESM2_ESM.xlsx-Sheet2_DESeq_MSC_vs_fibroblast-Unnamed_1_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.9727
BRD-K43889095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81197
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZB-16-BR73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.37742
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.674
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-6202-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.16734
VNN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0047855
BRD-K03562091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47377
AE-39-DG66_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.04105
GSE184892_6_v_1_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
olfactorybulb	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.16415
doxepin-2384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K07489055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33699
EC-82-LV30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.72514
EC-47-EO60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282984
Eye-limbal stromal cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.0895189
oxedrine-6156	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CNKSR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00780809
urinary system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.067397
PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12307501-Table1.xlsx-ST12-Supplementary_Table_12_Results_of_the_comparisons_of_AP_expression_levels_between_different_biological_age_groups_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mantle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.294223
Large_Intestine-intestinal enteroendocrine cell	Tabula Sapiens Gene-Cell Associations	1.0	0.948577
NFE2L3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523828
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.859831
CD151	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0061385
H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.954249
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RI-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A63998256_Helveticoside_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN013_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13264
GSE199255,GSE199356_6_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FAM220A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16109
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.925901
Perturb_5162_KD_Mbd2_SRP051519	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.48894
NANOG-21062744-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
mecamylamine-hcl	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19233
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
parietal neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.74016
CTCF_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE130396_0_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PIR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0113705
POU5F1-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A4ZW-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
brain stem	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.772759
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3358-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular amide metabolic process	GO Biological Process Annotations 2015	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1ME-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perianth	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.435
H3K27me3_G1E_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81418486_vorinostat_HA1E_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.742041
DICER1_KO_GDS4504_585_mouse_bone marrow granulocyte-macrophage progenitors	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
BE-28-WW67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.397931
Invasive lobular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.362
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K54141134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33125
MRGPRX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524922
BRD-K45631723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18287
Skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MKN74	CCLE Cell Line Gene Expression Profiles	-1.0	-1.94905
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CIB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0114972
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.94629
spinal cord	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
1544_CHAF1A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01924
inhibit	GeneRIF Biological Term Annotations	1.0	null
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.958634
BRD-A11512624_NCGC00181381-01_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NANOG-16518401-CHIP-PET-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Hyperglycemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
BRD-K73899967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41463
BRD-K81418486_vorinostat_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TMEM216	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00701119
GSE151612_4_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224366
GLI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00757439
intracellular part	GO Cellular Component Annotations 2015	1.0	null
JOPACA1	DepMap CRISPR Gene Dependency	1.0	3.24006
TM9SF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0492
SHLD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02497
BRD-K59709341	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0597
1878_CRNKL1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0293
WAOSEL	DepMap CRISPR Gene Dependency	1.0	6.03191
plasma membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.053341
MCF7_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0153136
BRD-K81418486_vorinostat_EFO27_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BCL6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1752
NANOG-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_1065_Mut_Esr1_SRP087718	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.39257
Prostate adenocarcinoma_PRAD_TCGA-HC-7752-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skeletal system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K94913575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26853
Perturb_8654_KO_ESRRA/ESRRG_SRP304242	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
GTEX-P44H-0011-R1A-SM-3NM8J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905938
GSE153836_11_v_9_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Invasive ductal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
BRD-K18190982_COT-10b_HT29_24.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K99521908	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10152
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.856579
response to stress	GO Biological Process Annotations 2015	1.0	null
BRD-K43620258_3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide_CL34_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.949307
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.919527
decreased stereotypic behavior	MGI Mouse Phenotype Associations 2023	1.0	null
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.619
Orbital area, medial part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31886
GSE138863_3_v_0_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
6842_PSMA2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.04099
Lung adenocarcinoma_LUAD_TCGA-55-8620-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K35945596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.15613
RPS6KC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0070615
Pyramus (VIII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.75039
MCF7_Tie2 kinase inhibitor_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0140614
GTEX-U3ZN-2226-SM-3DB88	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07759
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GRM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00586528
BRD-K66222602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01476
MCF7_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00879767
BRD-K94540403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79073
7525_RPS3_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.36631
BRD-K81418486_vorinostat_PC3_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
viscus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.263669
CRCGN012_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37607
PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-CLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
triamcinolone-1395	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE239541_5_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
3436_RACK1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.47869
WNT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00646597
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A654-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K87158025_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RCOR1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FADS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00573734
Perturb_4990_KO_Ctnnb1_SRP240867	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.7702
Specific developmental disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.281
BRD-K69840642_HDAC6 inhibitor ISOX_SNUC4_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Disorders of Excessive Somnolence	CTD Gene-Disease Associations	1.0	1.0353
DGKZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00434629
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.112
BRD-K08799663	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.86292
CDC23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33626
BRD-K42123500	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05969
Annuli extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.959
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
350_ANLN_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22828
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.883407
QD-32-CW16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224859
Internal iliac artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.686
9303_TRMT112_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01705
BRD-K78306305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41226
FABP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00663173
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839898
GSE181821_1_v_3_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCI-H727	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.988779
Perturb_3896_KD_VprBP_SRP328755	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Inflammation	CTD Gene-Disease Associations	1.0	1.46542
BRD-K41192068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3482
GSE217405_0_v_2_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
7510_RPS20_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.92179
BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_U937_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FUT8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00632794
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPN-0011-R7A-SM-2I5FI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14823
E2F4	ENCODE Transcription Factor Targets	1.0	null
BRD-K49864183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50741
4921_MDN1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03535
benfluorex-5327	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
42-MG-BA	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93416
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K98548675_Parthenolide_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRPF38B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00563875
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5085-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79395
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.09074
cell part	GO Cellular Component Annotations 2015	1.0	null
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.57782
7312_RIOK2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.38992
EP300	ENCODE Transcription Factor Targets	1.0	null
CB-32-EI69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.236725
STK16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00567142
5738_NOL9_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21825
Pod	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.519
Ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.569
NDUFB8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00485806
T47D	CCLE Cell Line Gene CNV Profiles	1.0	1.57257
BRD-K11129031_GEMFIBROZIL_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PWN1-1626-SM-2S1OL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23727
SP1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Ventromedial hypothalamic nucleus, central part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70151
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00362
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
KARPAS-299 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.643
Psychomotor Disorders	CTD Gene-Disease Associations	1.0	1.21435
abnormal voluntary movement	MPO Gene-Phenotype Associations	1.0	null
BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8XH-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4813_KO_Apex1_SRP193096	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.6407
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZNF701	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.8854
BRD-K36055864_CYCLOHEXIMIDE_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
extracellular space	GO Cellular Component Annotations 2015	1.0	null
ATF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51094
BRD-K86899078_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NANOG-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CYP51A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00741476
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9841_WDR75_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.08857
medial ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.17274
ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.31187
Folic Acid	CTD Gene-Chemical Interactions	1.0	null
KDM4A	ENCODE Transcription Factor Targets	1.0	null
Orbital area, medial part, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.74035
H3K4me3_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-UPK5-0326-SM-3GAF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
CYTH4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00783158
prostate	HPA Tissue Protein Expression Profiles	1.0	1.18895
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.24381
mdamb134vi	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.849
BRD-K86856088_UNC0638_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K73402542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66106
Perturb_5279_OE_Mnx1_ERP140947	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.71624
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.721925
PMC7412812-13059_2020_2115_MOESM11_ESM.xlsx-All_EZH2-Upregulated_in_SERBP1_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
oleandomycin-2018	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intermediate stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6548
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
CTRL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00932413
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.7887
OF-05-CB18_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.681485
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7880-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K86935536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79762
GSE205070_1_v_6_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRC2_SUZ12_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
CD79A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0117916
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
FCGR3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00771412
BRD-K18768055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05725
BRD-K60557007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19527
urinary system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE122215,GSE122217_0_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A182-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hypertension	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.67
TAF1	ENCODE Transcription Factor Targets	1.0	null
BRD-A58767537_afatinib_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE234340_12_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
9839_WDR74_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03772
REST-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
1469_CEBPG_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.79108
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Unnamed_4_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3298
TMEM255A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00486762
BRD-K79619334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08518
NRF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6574_POP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03239
Necrosis	CTD Gene-Disease Associations	1.0	1.88109
GTEX-OXRO-1926-SM-2S1O3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
RCOR1_02_204	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.3505
BRD-K86797399_pracinostat_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Frontal pole, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.20744
BRD-K13810148_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRACR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.8805
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USH1G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49277
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K69840642_HDAC6 inhibitor ISOX_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K63420290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18856
BRD-K76899562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63702
negative regulation of hydrolase activity	GO Biological Process Annotations 2015	1.0	null
CTCF_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Venom sac	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.504
Perturb_7426_KD_RC3H1/RC3H2_SRP058191	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.6743
GTEX-PWO3-0011-R8A-SM-2I5GD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10023
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870476
GSE182680,GSE182683_7_v_11_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TSE9-0011-R6A-SM-3DB7L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.174
pravastatin-lactone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87683
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A519-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GE-98-ZI68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.423799
ME-31-RM40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.409046
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20H-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K90697690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4992
Kidney renal papillary cell carcinoma_KIRP_TCGA-SX-A7SL-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K86797399_pracinostat_HCC515_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Human - Fetal Development - L1 - Islet endocrine cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900378
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.914354
LRBA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0118397
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9232687-13238_2021_887_MOESM3_ESM.xlsx-37_KD_sgCDC20_vs_sgNTC-Differentially_expressed_genes_DEGs_upon_CDC20_knockdown_under_37_culture_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
supramammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.40595
GTEX-T5JC-0011-R1A-SM-32PM6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11488
Pituitary adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.068
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
alzheimer disease specific cell type	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.305722
LUDLU1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.35837
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KJ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.42672
CTCF_Caco-2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15563106_-666_AGS_6.0_h_177.6_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
BRD-K17743125_belinostat_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
GTEX-RVPU-0011-R3A-SM-2XCAE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886675
GTEX-T2IS-0011-R2A-SM-32QPF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964744
VGLL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00356302
VZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.5109
regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
CE-15-YU05_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219243
Perturb_16099_KO_Eed_SRP125082	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.9381
differences	GeneRIF Biological Term Annotations	1.0	null
SLC5A11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00970231
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.4194
INPPL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00662601
mantle zone of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18725
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112358,GSE112359_0_v_1_med23_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
chromaffin cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.23781
BRD-K31836496	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26837
BRD-A52660433_Tetrindole mesylate_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN2_n_EN2	Rummagene Transcription Factor Associations 2026	1.0	null
GZMB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585257
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.05091
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.7456
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Bipolar Disorder	CTD Gene-Disease Associations	1.0	1.09154
lateral ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.174263
GSE261563_9_v_8_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X88G-0008-SM-47JWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09957
CHRNA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00579117
2111_DDX21_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.75349
BRD-K92428232_GSK-461364_PC3_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07626
GSE109285_3_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57682
HTR1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067204
4107_IMP3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.28005
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.167366
endopeptidase inhibitor activity	GO Molecular Function Annotations 2015	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-PVOW-0011-R3A-SM-32PKX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831318
multicellular organismal process	GO Biological Process Annotations 2015	1.0	null
BRD-U01690642_G-221_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-N7MS-0011-R7a-SM-2HMKN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06218
FCRLB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00646112
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
FIZZ2_KO_GDS4902_408_mouse_Lung	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
CTCF_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDC14A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00774139
BRD-K99482176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00463
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
7512_RPS23_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.63414
Small_Intestine-intestinal enteroendocrine cell	Tabula Sapiens Gene-Cell Associations	1.0	1.77525
A549_Mocetinostat_1µM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124884
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K97470305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0672
BRD-K26461918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15361
peptide metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE157555,GSE157556_3_v_2_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K42457027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34375
VZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.93002
Reflex, Abnormal	CTD Gene-Disease Associations	1.0	1.66317
WDR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22282
HPRT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00523603
GSE201309_1_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07691486_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K85493820_KM 00927_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VPS18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614221
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.56279
captopril_mus musculus_gpl1261_gds3683	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OHPK-1326-SM-3MJGN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892525
BRD-K20724649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59712
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12499
FBXO21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36103
Prostate adenocarcinoma_PRAD_TCGA-G9-6369-01A-21R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cuneate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33943
hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Gizzard	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.749
AKT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00270783
cell	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.289938
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58066822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00356
3891_HOXA3_P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.64064
CRCGN014_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.70658
7455_RPL27_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.33241
LC1SQSF	CCLE Cell Line Gene CNV Profiles	-1.0	-2.09288
REST_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7577_RSL24D1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03824
CD160	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604567
496100347_PCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.21409
BRD-K71554049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6513
CRTC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00483711
mantle zone of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.15929
BRD-K81418486_vorinostat_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-R55F-0011-R6A-SM-2TF4L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09844
SV2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00804505
intermediate stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.01543
CDK18	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00569913
BRD-K42361742	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57444
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.195681
Lateral visual area, layer 6a	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19899
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.83901
FD-59-TC81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07663
growth/size/body phenotype	MPO Gene-Phenotype Associations	1.0	null
GSE208096_1_v_0_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
9814_WDR33_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.42882
superficial stratum of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08248
AB-33-EM56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231412
Androgen insensitivity syndrome_Fibroblast_GSE3871	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.99791
GTEX-RM2N-1826-SM-2TF5B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
ventral premammillary nucleus (migrated)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.41706
FN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00431874
GSE126345_7_v_10_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TNK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00499677
MDAMB361	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.22524
SKMEL30	DepMap CRISPR Gene Dependency	1.0	4.57672
amygdaloid complex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.59318
GSE144231_2_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRMT5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00526796
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.591
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26442
BRD-K83544408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89953
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
6866_PSMD12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.44003
NCI-H1092	GDSC Cell Line Gene Expression Profiles	1.0	1.58184
BRD-K37684893	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.21805
7442_RPL18A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.39485
Neurobehavioral Manifestations	CTD Gene-Disease Associations	1.0	1.4065
HAPLN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00536249
hemicholinium-1601	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_9700_KO_TREX1_SRP355094	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
1458_CDT1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06782
GSE199255,GSE199356_4_v_5_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.586
MCFD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0107146
A549_Abexinostat_1µM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113419
FOXE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04782
Dendritic lamellar body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.045
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.908009
Spinal cord	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K17895004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05827
GSE210580_4_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
UACC893	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.57972
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
AQP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614106
NCIH3255	CCLE Cell Line Gene CNV Profiles	1.0	1.91156
CTCF_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
639V	DepMap CRISPR Gene Dependency	1.0	2.04158
BFAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04293
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.107
7469_RPL38_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.86834
HUVEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.850772
Perturb_14678_KO_Prmt1_SRP153406	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
interactions	GeneRIF Biological Term Annotations	1.0	null
PMC4860404-Table1.XLSX-MR_specific-Table_S1-9_DEGspecific_for_mouse_rat_SCI_at_1_dpi_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
Pituitary gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.839
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7479
MRPL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26721
NH6	CCLE Cell Line Gene Expression Profiles	1.0	1.65961
GSE164757,GSE164759_1_v_2_trametinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LCAM1	DepMap CRISPR Gene Dependency	1.0	3.23576
Perturb_4538_KO_Mtf2_SRP103933	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.49492
BRD-K12930517	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97683
H3K4me3_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K33720404_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ventral tuberomammillary nucleus, superficial part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.97232
AC-44-UR36_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.29071
BRD-K17659275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63215
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
ChIP_POU5F1_18700969	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K58586013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32612
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R9-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FAR/SIN/STRIPAK complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.871
GTEX-WHSE-0011-R4A-SM-3P5ZN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933005
H3K27me3_kidney epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7466_RPL36_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.93317
BRD-K59182232	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47366
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.71662
CTCF_G1E-ER4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K51160592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57639
candesartan_rattus norvegicus_gpl341_gse4206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I1-06A-12R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
2983_FAU_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.38856
internal segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.848979
ERBB2_knockdown_238_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.37349
GLYCTK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00989427
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.00614
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054493
BRD-K29441085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48881
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.446
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
9498_UBE2D3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10315
ACSS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00516213
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67V-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MOB3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0114653
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.200663
dorsal part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59109
BRD-K22071228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83404
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961904
EFCAB14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.27801
GTEX-OHPN-0011-R1A-SM-2I5GB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.935298
GTEX-OIZH-3026-SM-3NB1G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.909602
MGAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00636879
cuneiform nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20767
JAG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00695903
10702_ZNHIT6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12769
PDE2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00753226
BRD-K57631554_aminolevulinic acid_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DSEL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00605658
BRD-K51568355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63509
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K24031526_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RU72-0011-R5A-SM-2TF6U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03005
SIPA1L3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00852518
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.932841
BRD-K29685390	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18975
DD-82-GV50_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276424
16474848-Table2	GeneSigDB Published Gene Signatures	1.0	null
ZNF669	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.765
DC-93-NP78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.310765
CRCGN011_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06815
molecular_function	GO Molecular Function Annotations 2015	1.0	null
KLF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	73.999
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.43571
GSE232714_0_v_1_raver1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Neuroendocrine tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
GTEX-QVJO-0011-R2A-SM-2S1QK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824888
BRD-K87010860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02605
Urothelial carcinoma_Urothelium_GSE3167	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.36491
lateral reticular nucleus (principal part)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.14478
BRD-K18163752_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KLF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	288.824
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345586
MS4A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00766017
Learning Disorders	CTD Gene-Disease Associations	1.0	1.83325
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8660_TAF1D_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.62773
enzymes	GeneRIF Biological Term Annotations	1.0	null
intracellular organelle part	GO Cellular Component Annotations 2015	1.0	null
BRD-K12502280_TG101348_AGS_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T2IS-3126-SM-32QPK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67714
CRCGN015_MCF10A_48H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.71154
A253	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.06673
Left_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.28452
BRD-K36798110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65238
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13456
KE-37-MN32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.35704
BRD-K77908580_entinostat_HEPG2_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.662
HNF4G	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2554
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AF-01-FE42_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203963
SEC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06072
BRD-K37387086	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45014
BRD-K61829047_7b-cis_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K56884305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01948
GPR22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614925
SVEP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554519
Perturb_13209_OE_Foxd3_SRP060372	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.0413
GTEX-WEY5-2126-SM-3GILK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
second (ventral) preoptic domain	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0039
BRD-A19037878_trichostatin A_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE149769_1_v_0_nlrp12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
pituitary gland tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.11509
amygdaloid complex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.942934
Prostate adenocarcinoma_PRAD_TCGA-QU-A6IO-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.649851
AIF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00744267
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4887-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U343	DepMap CRISPR Gene Dependency	1.0	3.00002
Gamma delta T-lymphocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.221
BRD-K88000297	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46661
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64890080_BI 2536_SNUC4_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
4713_LTV1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.70795
MBNL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00625452
frontal pole, right, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.05202
Pituitary gland benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
BRD-K08640512_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OVSAHO	CCLE Cell Line Gene Expression Profiles	1.0	1.36083
BRD-K15519488_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Midbrain central gray	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.017
GTEX-S4UY-0526-SM-3K2AN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
UD-07-US73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230797
GSE119498_2_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Tcf1_KO_GDS1473_307_mouse_Pancreatic islets	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
AB-33-EM56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.340092
GTEX-NPJ7-2726-SM-2I3FT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93818
2225_UTP25_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20386
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.998426
Arthritis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
RPL13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00867796
PSMC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.61534
lateral subdivision of BNST	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11669
BRD-K12867552_THM-I-94_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VZ in septal region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.96684
forebrain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.869794
PIK3C2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620133
BRD-K92479346	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.18287
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A9FH-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
4805_MAP2K7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.64035
URB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19505
RB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00751168
1396_CDC27_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12783
endocrine pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.179661
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19453
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Thalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.081
Crus I, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.874916
B4GALNT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00557747
Insulinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.06
CCC5	DepMap CRISPR Gene Dependency	1.0	3.64781
BRD-K70945620	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22516
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.46172
FBXO32	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00608213
BRD-K88988134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43093
GTEX-WVLH-0011-R6A-SM-3MJFZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0473
GSE120413,GSE120447_0_v_2_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-18-GQ83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30545
GSE193541_0_v_3_nifurtimox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RPS29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66434
GTEX-X4XX-0011-R4B-SM-46MWL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04866
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.696
GTEX-X585-0011-R4B-SM-46MVH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18816
2105_DDX18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.63843
BF-49-QA17_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.02786
GTEX-WVLH-3126-SM-3MJGA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.29587
nrf1_22586274_liver_lof_mouse_gpl4134_gse35124	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.010221
BRD-K17743125_belinostat_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PPT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00329643
MICOS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.552
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.29475
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.1626
BRD-A75409952_wortmannin_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214931_4_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE240896,GSE240899_10_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SMC3_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC12171002-jcav16p2578s1.pdf-68-BAZ2B-A_BAZ2B	Rummagene Transcription Factor Associations 2026	1.0	null
2580_EIF6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03089
GATA1	ENCODE Transcription Factor Targets	1.0	null
BRD-K81418486_vorinostat_HCC515_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00731063
VZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.939008
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.65
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.38871
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.42975
PMC7934853-jciinsight-6-141851-s210.xlsx-Beta3-Unnamed_0_BHLHE22	Rummagene Transcription Factor Associations 2026	1.0	null
neuron projection membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.460401
CYP2A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00414061
CDO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00857862
BRD-A55594068_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Frond	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.737
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.0183
inferolateral temporal cortex (area TEv, area 20)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.860093
RIGI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599511
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884784
Insulin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.579
b16f0	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.886
suprachiasmatic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05784
diethylstilbestrol_rattus norvegicus_gpl1355_aci_gds2913	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SLC7A14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00889096
Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.575
GD-82-CS38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.227769
NANOG-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE204811,GSE204813_1_v_3_trim29_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K82928847_rocilinostat_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal behavior	MPO Gene-Phenotype Associations	1.0	null
GTEX-T6MN-0011-R10A-SM-32QP7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.956923
Pain	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-A19037878_trichostatin A_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.494315
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.28311
ARL5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00727828
PAPSS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.51219
resveratrol-1715	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-V1-A8WW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic islet	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.705
2321_DNTTIP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.61305
MDAMB361	CCLE Cell Line Gene CNV Profiles	1.0	2.20938
NCIH596	CCLE Cell Line Gene Expression Profiles	-1.0	-1.63737
RF-36-EI47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.358811
5821_NSA2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18393
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4153_INTS8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.83512
PI4K2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00653689
SGF29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77557
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.59504
9857_WEE1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.99546
TNFSF9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067008
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08378
BRD-K68073004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39778
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ERAP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00743353
BRD-K94191869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04417
BE-82-TS38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262164
SNAI1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00560306
DRD5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0123379
Perturb_4940_KO_Cbfa2t2_SRP061948	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.30074
Nectary	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.479
BRD-K74305673_IMD 0354_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
seneciphylline-2797	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Growth Disorders	CTD Gene-Disease Associations	1.0	1.12288
posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05922
BRD-A14966924_ALAPROCLATE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AC-31-PL89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.617831
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.25306
PD-70-VS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.49148
AC-55-GO91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204187
BRD-K15402119_H5902_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MTCH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00711994
CBX6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00476069
HCC38	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3514
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.71145
BRD-K81418486_vorinostat_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ERBB2_knockdown_237_GSE8373	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.91629
REST	ChEA Transcription Factor Targets	1.0	null
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.84478
IRF8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00837136
Perturb_7492_KD_TAF6_SRP174861	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.0894
vorinostat_homo sapiens_gpl6947_gse41504	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MMP23A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00911731
BRD-K90655269	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41782
Perturb_5163_OE_miR294_SRP051519	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.95324
FD-62-ZB67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.377745
ERG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559814
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18892
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360692
BRD-K72565671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76218
ABT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41451
WD-62-UB45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21984
Ventromedial hypothalamic nucleus, dorsomedial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.51233
LDLR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00384234
5190_MRGBP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31771
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.855376
BRD-K73789395_ZM 336372_A549_6.0_h_102.71_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_16639_KO_Tardbp_SRP278199	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.6537
BRD-K57748937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13548
BRD-K88421348	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02017
Perturb_13273_KO_Spen_SRP198728	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.78682
2226_DIMT1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0604
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
spinal column	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BT-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
B9D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554009
9656_USP39_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.17601
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14723547	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68649
dydrogesterone-2811	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
endopeptidase regulator activity	GO Molecular Function Annotations 2015	1.0	null
BRD-A19037878_trichostatin A_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H3122	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93416
SLC1A7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00441269
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Unnamed_1_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
trastuzumab_homo sapiens_gpl570_gse15043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S3XE-1826-SM-3K2B4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.709437
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.41087
NIX_Deficiency_GDS2630_655_mouse_Spleen	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_6280_KO_TP53_SRP200689	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-1.8551
MEST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520771
BRD-K77519898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20893
KPNRTBM1	CCLE Cell Line Gene Expression Profiles	1.0	1.80394
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.476
GSE143944_2_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
METTL7A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00906124
BRD-A37735495_2-[(chloroacetyl)(4-fluorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SUCLG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00828713
cyclizine-5525	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
REST	ENCODE Transcription Factor Targets	1.0	null
CTCF_fibroblast of pulmonary artery_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A79465854_auranofin_JHUEM2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BA-88-HT15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.389903
JE-72-KV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396066
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01975
hsa-miR-3942-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.303626
Connective tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.226
Lung adenocarcinoma_LUAD_TCGA-64-5778-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_14413_KO_ARID1A_SRP355686	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
RAD21_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
18702172-Table3	GeneSigDB Published Gene Signatures	1.0	null
mammalian phenotype	MPO Gene-Phenotype Associations	1.0	null
protein processing	GO Biological Process Annotations 2015	1.0	null
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
clioquinol-5623	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K35614154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02848
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65807
BRD-K92879007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04797
posteroventral (inferior) parietal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36435
FB-39-CW59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271343
SSTR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00530592
Amyotrophic lateral sclerosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.131
5737_NOL8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05022
7585_RTF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.22286
ATXN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0067243
GSE217363_2_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
CDH24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38229
GTEX-WHSE-0011-R8A-SM-3P5Z1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45152
BRD-K48999921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14336
BRD-K08438429_NNC 26-9100_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4875-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NEK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00636545
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1908	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
g-protein coupled receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
Hmx2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	32.1144
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K62200014_ANAGRELIDE HYDROCHLORIDE_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
blood	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MAMSTR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635474
ARID3A	ENCODE Transcription Factor Targets	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RD-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LD-69-ZV56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.506772
KANK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.09696
CA4 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27753
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053701
kidney_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.46622
TMEM223	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14211
ventral tuberomammillary nucleus, intermediate part (histaminergic)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.0169
CRCGN015_HEPG2_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6013
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04977
Hyperplasia	CTD Gene-Disease Associations	1.0	1.36218
1671_CLP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.41319
Perturb_4680_KO_Psip1_SRP153901	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.62306
Lung adenocarcinoma_LUAD_TCGA-55-8207-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VPS13C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00602239
Crus 2, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.16777
kidney	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.595656
GSE146982_3_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RNOR-2326-SM-2TF4I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85311
Brain Lower Grade Glioma_LGG_TCGA-S9-A7IY-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SLC6A8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00784115
C8A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005577
BRD-K44510578_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MSTO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00894189
BRD-K25127909	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42891
4950_MED27_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06033
lewy body	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.361659
Perturb_4941_KO_Prdm14_SRP061948	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.34705
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IA-65-QX27_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235596
PMC11383936-41598_2024_71738_MOESM6_ESM.xlsx-DEPs_LMS_vs_HC-Unnamed_4_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K36170758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20037
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SNU626	DepMap CRISPR Gene Dependency	1.0	2.58783
PHLDA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00580505
NANOG-21062744-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-A36275421_MW-ras12_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN015_HEPG2_48H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59849
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.354
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K83438939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55236
8933_TIPIN_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.28714
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K90004516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41807
BRD-K20199304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10998
BRD-K25016708	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04734
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_2_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
Dorsomedial nucleus of the hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20163
rostral secondary prosencephalon	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24247
hippocampus (hippocampal formation)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36435
7481_RPL9_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21571
BRD-K77223020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26066
GSE223893_2_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Bardet-Biedl syndrome 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.175
MAX_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4363
U2OS	CCLE Cell Line Gene CNV Profiles	1.0	2.0071
QA-25-HL62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230337
RELB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00795231
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.35349
Folium-tuber vermis (VII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36057
BRD-K64785675_S1352_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
spinalcordlower	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.91931
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.08231
964_C12ORF45_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.44314
YY1	ENCODE Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_35 pcw_F_12295	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.24623
GSE199255,GSE199356_6_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.091
ICE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48102
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.742092
BRD-K74514084_pazopanib_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KF-18-RY71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268649
Neurohypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.162
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19073
FAM110D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15626
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.11643
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.263855
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4332
RAB6D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03136
GSE224599_0_v_1_tfcp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC11390959-41598_2024_70075_MOESM3_ESM.xlsx-520_DMD_common_down_gene_list-HES4_HES4	Rummagene Transcription Factor Associations 2026	1.0	null
layer 1 of FCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02069
1961_CUL2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.43823
levodopa-1972	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.203
2456_EBNA1BP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08747
STK32A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00790038
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55F-1426-SM-2TF53	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04616
rin5f	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.727
GSE239844_4_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ceratobranchial	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.725
DPYSL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570035
BRD-K10031593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35182
496100554_FWM_no dementia_no TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.79391
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21919
Ventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.722
ATP4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620047
EB-19-SM10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.304619
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SH-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A39646320_H7270_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-N7MT-0011-R5a-SM-2I3G6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03926
GTEX-RUSQ-0526-SM-2TF72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
3445_GNL2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07415
CAPN15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0113716
GTEX-PVOW-2726-SM-48TCA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.74711
BRD-K09499853_KU 0060648 trihydrochloride_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
9672_USP5_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23709
Dorsomedial nucleus of the hypothalamus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29187
BRD-K41888813	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40114
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.858106
WDFY4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00758495
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02889
NR2C2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626677
7437_RPL13_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.39376
BRD-K26689527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00829
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.27642
7522_RPS2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.44507
ZFAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45626
BRD-K56343971_HY-10247_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
fasciola cinerea	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.49262
phaeochromocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.637889
Lingula (I), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.2862
GTEX-NPJ8-1426-SM-3MJHR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.54882
KLF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00902766
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19892
FAM234B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3864
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.042619
layer IIIu of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.855671
Ataxia	CTD Gene-Disease Associations	1.0	1.2352
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053855
BRD-K14019014	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30267
inclusion body	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.357086
endopeptidase regulator activity	GO Molecular Function Annotations 2023	1.0	null
GTEX-TSE9-0011-R8A-SM-3DB7R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23594
BRD-K19567079	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07713
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.863837
NCIH2196	CCLE Cell Line Gene Expression Profiles	1.0	2.00845
extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
OPRM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00613273
HCC2935	CCLE Cell Line Gene Expression Profiles	-1.0	-1.55182
PMC7412812-13059_2020_2115_MOESM11_ESM.xlsx-All_SUZ12-Upregulated_in_SERBP1_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HUH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
2074_DCTN2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00873
GTEX-NPJ7-2926-SM-3MJGQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61845
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
HAO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00662059
pineal body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.84958
BRD-K63024248	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18688
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.313848
Prostate adenocarcinoma_PRAD_TCGA-FC-A66V-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Resminostat_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00876645
BRD-K29383520	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71739
ARPC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00413361
Perturb_16106_KO_Bap1_SRP360900	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
secretory granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.463997
PRKAG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00746692
GSE218580_1_v_4_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_14675_KO_RpL13a_SRP090469	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.59572
H3K27me3_cardiac mesoderm_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.781
BRD-K39498165	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06002
CD-20-MH57_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.288543
PMC4860404-Table1.XLSX-MR_unique-Table_S1-7_DEG_unique_in_mouse_and_rat_SCI_at_1_dpi_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08853
CLEC1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00739342
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_3697_KD_FTO_SRP226373	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.05936
paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.70817
CEPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48315
E2F4	Pathway Commons Protein-Protein Interactions	1.0	null
AOB, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.26234
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03156
5084_MIS18BP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.56034
GTEX-XMD1-0011-R8A-SM-4AT48	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868079
Periventricular region	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13551
MYL9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510082
IL13RA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00745135
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
RA-42-CM42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.335304
cerebellar cortex_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.947184
BRD-K05433219_SERICETIN_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
4152_INTS7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.52765
NMC-G1	GDSC Cell Line Gene Expression Profiles	1.0	1.51581
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE140965_2_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.252774
diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.313189
bethanechol-5539	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K46622484	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06873
GSE226584,GSE226589_3_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7453_RPL26_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.35904
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67W-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32819
PMC7870953-41540_2021_169_MOESM9_ESM.xlsx-RREB1_targets-target_gene_RREB1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U4B1-1726-SM-3DB9F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Ktp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.648
Lung adenocarcinoma_LUAD_TCGA-55-A494-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T2IS-3026-SM-32QPM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838174
GSE202434,GSE202438_9_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QB-42-MC63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.219061
COR-L311	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93416
SLC7A7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00676197
BRD-K13110820	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82824
Mild cognitive impairment	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
LSM11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.55651
GSE111247_11_v_9_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81418486_vorinostat_EFO27_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE147876,GSE147877_2_v_10_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
POU5F1-18700969-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
SDC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00608946
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFM-192C	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.9887
GSE261563_6_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYNN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13744
Perturb_7472_KO_RBBP8_SRP142730	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.278
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.505018
BRD-A32214171_7706-0030_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AA-62-HP31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201234
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.982647
BRD-K88996011	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25729
BRD-K63154470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67417
1346_CCT2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09248
MCF7_Givinostat_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.00580146
BRD-K32205799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17753
Schizophrenia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.11
Lamellar body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.906
abnormal anxiety-related response	MPO Gene-Phenotype Associations	1.0	null
MAGEH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.03555
LTA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00708171
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
AC-43-ZC52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.731292
PMC10806738-mmc2.xlsx-Table_S1-Table_S1_Table_of_significantly_adjusted_p-valued_0_05_up-regulated_genes_log2FC_1_in_MAX-R60Q_transfected_HEK293_cells_relative_to_MAX-WT_transfected_cells_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GSE224763_1_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228992_0_v_1_mafb_human	RummaGEO Gene Perturbation Signatures	1.0	null
WNK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00650489
BRD-K33805386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16939
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4841-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of peptidase activity	GO Biological Process Annotations 2015	1.0	null
BRD-K74148702_curcumin_WSUDLCL2_6.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JD-58-MV19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230463
posterior (caudal) superior temporal cortex (area 22c)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.77658
Bursa of Fabricius	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.634
BRD-K24132293_piperlongumine (HPLC)_SW480_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FF-06-MO73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.34282
adult retina	HPM Cell Type and Tissue Protein Expression Profiles	1.0	1.14787
Pick Disease Of The Brain	DisGeNET Gene-Disease Associations	1.0	null
GSE157555,GSE157556_0_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QEG5-0626-SM-2S1PP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944091
Ansiform lobule	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11255
EHBP1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00724304
tranexamic acid-1401	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OXRN-0011-R10A-SM-2I5GC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880649
regulation of proteolysis	GO Biological Process Annotations 2015	1.0	null
kidney	HPA Tissue Gene Expression Profiles	1.0	1.44352
GTEX-NPJ8-0011-R4a-SM-2HML3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824663
BRD-K48722833_S1483_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
P2RY2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0122075
POU5F1-18347094-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
DKC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00619696
496100562_FWM_no dementia_TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.51488
S0-EE-YMWJ_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259955
CLEC11A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0128667
GSE193258,GSE193259_5_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ACTR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063109
CTCF_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829915
A549_Quisinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0216786
REST	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.4014
RBFOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21735
BRD-K50128260_Sildenafil citrate_NCIH596_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MYBL2	ChEA Transcription Factor Targets	1.0	null
MMP23B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00894942
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
extracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
regulation of endopeptidase activity	GO Biological Process Annotations 2015	1.0	null
GTEX-WFG8-0626-SM-3GILJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
CD59	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00438048
BRD-K70305913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.186
primary auditory cortex (core)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.863573
CD274	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00677582
MCF7_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0150221
GPI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00454166
GTEX-T8EM-1626-SM-3DB7K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20667
CF-65-GU65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.930982
BRD-K52397688_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RNF186	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00682026
GTEX-UJHI-1926-SM-3DB8Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830573
Muscle myosin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.879
HICS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.706
CTCF_retinal pigment epithelial cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ6-0226-SM-3P61I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836301
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299704
Pain agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.154
cytoplasmic membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GSE239844_8_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.935701
Perturb_4767_KO_Kap1_SRP065215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-17.0132
decreased body weight	MPO Gene-Phenotype Associations	1.0	null
KLF17	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.283
BRD-K74761218_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EHD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00689206
19838208-TableS1	GeneSigDB Published Gene Signatures	1.0	null
OE-84-HO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.494431
BRD-K48557872	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76009
7458_RPL30_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.54077
7418_RPA1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00302
RSBN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0040647
inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.59318
each	GeneRIF Biological Term Annotations	1.0	null
GSTA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00495843
paraventricular nucleus, peduncular or principal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14411
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.61108
DMPK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00526783
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963055
axolemma	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.461599
intracellular	GeneRIF Biological Term Annotations	1.0	null
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.72765
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05598
REST_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.456
496100278_FWM_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.14508
BRD-K93480852_KN-93_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K77908580_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EHHADH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0142612
RB-34-TO07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204696
GTEX-WHSE-0011-R5A-SM-3P5ZO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14484
Corolla tube	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.863
BRD-A19037878_trichostatin A_HCC15_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K88378636_withaferin-a_SKBR3_3_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Nerve Degeneration	CTD Gene-Disease Associations	1.0	1.09471
Functioning pituitary adenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.085
BRD-A76490030_K784-3131_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K93396907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01586
BRD-K86797399_pracinostat_HT29_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6597-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SUZ12	ENCODE Transcription Factor Targets	1.0	null
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34823
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00362
ND-07-WN37_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201767
LN428	DepMap CRISPR Gene Dependency	1.0	2.18152
DC-47-KV62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.538197
BRD-A52729710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35206
BRD-K81418486_vorinostat_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HNF4G	ENCODE Transcription Factor Targets	1.0	null
HT144SKINFV2	DepMap CRISPR Gene Dependency	1.0	4.70418
Epithalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.537
TNKS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00675265
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Orbital area, medial part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.01118
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.75143
BRD-K45044657_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-G6-A8L7-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10107781-NAN-49-0-s002.xlsx-NGS68_MBNL2_KO-vs-WT_log2FC0-4-GRCh37_87_MBNL2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE174701_4_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
temporal lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.377996
BRD-K85123403_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormal lung morphology	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K04710685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06412
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ENAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00659724
BRD-K16364953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07918
central nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.06507
GSE217405_0_v_1_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
citiolone-2176	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
methotrexate-1599	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K55116708_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
central part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6699
CRCGN009_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.41569
SREBF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal total tissue mass	MPO Gene-Phenotype Associations	1.0	null
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
EGR4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	197.481
Anxiety Disorders	CTD Gene-Disease Associations	1.0	1.7418
623 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.96
BRD-K50590187_(E)-capsaicin_OV7_6.0_h_160.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
5891_NUP205_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.48841
ARPC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00870549
6841_PSMA1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.88824
Paraflocculus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.15812
TMEM156	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00582343
GTEX-TSE9-0011-R10A-SM-3DB7O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04996
PAPSS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625668
GSE148252_1_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K19103068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34074
SPACA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01255
AB-84-PK04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229317
BRD-K12524104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63051
Perturb_14940_OE_hPRDM15_SRP182668	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.47188
properties	GeneRIF Biological Term Annotations	1.0	null
PE/CA-PJ15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16558
Dopaminergic synapse	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.749
NCKIPSD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622203
FKBP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00597023
secretory granule	GO Cellular Component Annotations 2015	1.0	null
NCI-H2227	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.53196
BRD-A03436432_NCGC00182942-03_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC4823830-ncomms11171-s3.xlsx-high_in_shRNA_GATA3-GeneSymbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
MMP19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00784524
BRD-A60245366_AS-601245_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
posteroventral (inferior) parietal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.878812
GTEX-Q2AG-0011-R6A-SM-2HML7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.900916
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intralaminar nuclei	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08853
Medulla oblongata	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.066
negative regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
Perturb_14323_KD_PDK1_SRP234024	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
MECOM_KO_GDS3343_554_mouse_Hematopoietic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Pancreatic beta cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.648
GIMAP7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00603137
mantle zone of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.09831
Perturb_13217_KO_Mettl3_SRP109093	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.03267
Nuclear origin of replication recognition complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.538
Caudate nucleus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.169
MX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00716607
neuron part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.073903
BRD-K95264594	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00646
KCNMA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00639526
GTEX-TKQ2-1826-SM-33HB2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882192
LCLC-103H	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
9617_URB1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.36831
BRD-K35517098	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33564
enzyme regulator activity	GO Molecular Function Annotations 2015	1.0	null
OPRK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00900289
FAM200A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.60822
PMC7571286-tvst-9-11-16_s004.xlsx-MaxQuant_-_SRF-Unnamed_209_SRF	Rummagene Transcription Factor Associations 2026	1.0	null
TCF3-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K90769476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65597
BRD-A36630025_-666_A375_24.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
pituitary gland tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.11287
FIBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00812424
CTCF_A549_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
REST_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
IFI6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00429501
lower basal perifornical nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06651
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.869045
H3K27me3_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210580_4_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99455613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28211
NPM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00721708
GTEX-O5YV-0226-SM-48TBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03583
EPAS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1844
NCI H23	BioGPS Cell Line Gene Expression Profiles	1.0	1.14443
BRD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00685636
MMRN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00705486
GTEX-NL4W-0011-R8a-SM-2I3G4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34743
BRD-K44950949	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19744
PPP2CA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00708445
2993_FBXL14_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22898
UBA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00476014
CRCGN011_HEPG2_24H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0683
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-3_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
AA-22-UI44_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.96368
BRD-K02078126	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38589
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM81	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00919837
BRD-K01436366_XMD-1150_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6855_PSMB6_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09503
ADGRF5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00701079
MCF7_Alisertib_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122023
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.74574
PHF8	ENCODE Transcription Factor Targets	1.0	null
CDHR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68322
golgi apparatus part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.002666
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_13936_KD_TTC8_SRP345436	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
DB-34-QA60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.343063
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883698
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.871
BRD-K98016463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21287
CALB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00680463
BRD-K28467592	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34933
CORL47	CCLE Cell Line Gene Expression Profiles	1.0	1.72254
7691_SCFD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09788
hsa-miR-31-5p	MiRTarBase microRNA Targets	1.0	null
CEACAM6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00648133
SP8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	161.133
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18701
INSM1_Deficiency_GDS5066_272_mouse_Fetal pituitary glands from embryonic day 17.5	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Perturb_9517_Mut_Sall4_ERP111723	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.57314
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267819
BRD-K50894381	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20666
Perturb_1066_KO_Esr1_SRP087718	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-8.63095
4401_KIN_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0102
H3K27me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE147876,GSE147877_2_v_11_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
mantle zone of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75969
CRCGN013_HEPG2_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0058
GTEX-WWYW-0011-R6A-SM-3NB3G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03667
Vegetation	DisGeNET Gene-Disease Associations	1.0	null
GTEX-QDVN-2326-SM-2S1PF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
GTEX-R55E-0011-R9A-SM-2TC6C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04854
PMC6855629-pone.0225186.s008.xlsx-Sheet1-DEGs_downregulated_in_SK-N-SH_MEIS1_OE_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PWOO-0526-SM-2S1Q3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00178
urinary tract	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.066855
FCAMR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00606536
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23171
TSHZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15299
DOHH-2	GDSC Cell Line Gene Expression Profiles	-1.0	-2.09901
decreased stereotypic behavior	MPO Gene-Phenotype Associations	1.0	null
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
8820_TERF2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11462
BC-82-PP66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.537447
HCRT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00766188
ME-31-RM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.40349
BRD-K79730625	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05974
BRD-K33106058_-666_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Anxiety	DisGeNET Gene-Disease Associations	1.0	null
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0506
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857758
ventricular zone	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.393819
5879_NUFIP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01888
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A556-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Muscle-cd8-positive, alpha-beta t cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.163518
BRD-K03618428_PP-110_H1299_6.0_h_22.2000007629_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K71799778_BML-259_U937_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8666_TAF5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.77224
BRD-K73789395_ZM 336372_NOMO1_6.0_h_102.71_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RETSAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0084125
abnormal locomotor activation	MGI Mouse Phenotype Associations 2023	1.0	null
SUCNR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0090675
DSTYK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00830521
superficial stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.97232
GSE158834_0_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
peptidase regulator activity	GO Molecular Function Annotations 2015	1.0	null
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.68673
BA-39-HG26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261062
GTEX-V955-0726-SM-3GAFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-K61623863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.195
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K83972459_JWE-035_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.87417
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K85398599	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06039
GSE158632_3_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
KLRC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621769
GSE201309_1_v_8_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IL12B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00515833
Proventriculus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.747
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.8736
HES7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7503
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.987328
lateral dorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.867016
Pituitary gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
GSE157609,GSE158123_0_v_1_ifi16_human	RummaGEO Gene Perturbation Signatures	-1.0	null
subarachnoid space	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.570021
hMPV_24Hour_18234263_GSE8961	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-0.943893
GSE122215,GSE122217_5_v_1_peg10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Chronic kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.103
DGKB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00455914
CTCF_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
859_BMS1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45626
BRD-K54606188_(+)-JQ1_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GM97	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.45596
CREB3L4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494356
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.70693
CRCGN013_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20161
behavior/neurological phenotype	MPO Gene-Phenotype Associations	1.0	null
GSE139455_4_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123939
preoptic area	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.603295
Nkx3-2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.8022
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-LEF1_UP_V1_UP-Ensemble_gene_ID_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8384902-mmc6.xlsx-DEG_3TF_KD_unique-GeneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.096
BRD-K12202458	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0673
Crus 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03201
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Gynostemium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.596
GTEX-XYKS-1226-SM-4BRVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26319
membrane part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.047048
Lung adenocarcinoma_LUAD_TCGA-L9-A443-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.911813
PHYH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00481909
GTEX-QV44-0526-SM-2S1RE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980938
BRD-K58614056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10826
Pyramus (VIII)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.78138
Giant axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.571
PMC6987220-41467_2020_14312_MOESM5_ESM.xlsx-P53_Spheres-11_names_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
AB-18-YN11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215118
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.36309
4780_MAK16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.57883
stomach	HPA Tissue Gene Expression Profiles	1.0	0.849734
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6388
DMD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00586549
GSE164135,GSE164137_0_v_1_fbxw7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GIMAP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551813
5702_NLE1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05586
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.00086
Pancreatic alpha cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.555
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE228106_0_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100575_PCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.28741
EW8	CCLE Cell Line Gene CNV Profiles	1.0	1.48802
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07137
BB-86-UL91_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.435261
Perturb_9714_KO_miR34a_SRP058984	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.50896
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.701
METTL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549974
BRD-K23192422_L-6307_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K26612358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08841
6872_PSMD4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.63094
TCF3-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE110248_1_v_6_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K61772027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49175
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
NEPRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1491
PMC10016690-Table_3.xlsx-AKT1_vs_KLF4_deg_all-Significant_DE_genes_in_AKT1_vs_KLF4_meningiomas_KLF4	Rummagene Transcription Factor Associations 2026	1.0	null
Carcinoma, Adenoid Cystic	CTD Gene-Disease Associations	1.0	2.88009
ALPK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00527992
6537_POLR1D_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24218
CEACAM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521253
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K88671309	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02973
SOCS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36897
MAZ	ENCODE Transcription Factor Targets	1.0	null
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.887128
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HK-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.892045
PIM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593358
AE-04-SN76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.34193
duodenum	HPA Tissue Protein Expression Profiles	1.0	1.18895
GRM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00435578
AA-23-FM46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.563168
UBE2W	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.9113
negative regulation of protein processing	GO Biological Process Annotations 2015	1.0	null
BRD-K49328571_dasatinib_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K44833533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49545
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6D8-01A-31R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KYAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00617003
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.23376
CH157MN	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38277
Amyloid plaque	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.188
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me3_Neurosphere Cultured Cells Ganglionic Eminence Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K44908610	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25976
mammillary area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.18725
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SW948	GDSC Cell Line Gene Expression Profiles	-1.0	-1.43267
whites	GeneRIF Biological Term Annotations	1.0	null
6849_PSMB1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.35866
BRD-K72437469	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29281
PSMG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.1112
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
potently	GeneRIF Biological Term Annotations	1.0	null
GSE229973_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
10676_ZNF84_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31743
Perturb_4531_KD_Senp6_SRP060878	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.39474
GSE144231_2_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QA-07-KC40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.580629
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-7332-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A562-01A-11R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4269325-NIHMS634665-supplement-supp_table4.xls-H3K27me3_TRIM37_KD-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
mRNA_KLF4_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
MCF7_ITSA-1_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146678
BRD-K86797399_pracinostat_HT29_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K35404627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60342
GSE210580_3_v_2_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
4985_METAP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05212
Subiculum, dorsal part, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24115
NELL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00768977
Blood microparticle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.818
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TemporalLobe	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.98126
BRD-K00627859_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MECP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509614
GSE210580_3_v_11_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KPNYN	CCLE Cell Line Gene Expression Profiles	1.0	1.48611
BRD-K25447152	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70545
GTEX-W5WG-1626-SM-4LMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-K36923996	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57379
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.438313
shell part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.34463
BRD-K75041300	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11613
AD-51-FB60_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.424988
GTEX-NPJ7-0011-R4a-SM-2I3GJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834045
BRD-K76154866	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05813
PMC7591852__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01884
7206_RCL1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24387
JA-26-YQ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.443096
STX4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00472665
GSE118077_7_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.889079
BRD-K68984041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57624
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
7537_RPS7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.84642
ND-15-RC31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.264771
ZBTB14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.7469
NCI-H2227	GDSC Cell Line Gene Expression Profiles	1.0	2.45731
9219_TPX2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.58493
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.849581
GSE234340_4_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ChIP_POU5F1_18347094	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_SKM1_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Chromaffin granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.887
NDC80	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00593958
4423_KLF7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00593
AA-22-UI44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.56032
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.776477
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.895556
GSE111247_11_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.35988
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
negative regulation of biological process	GO Biological Process Annotations 2015	1.0	null
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.872
BRD-K61451401	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04895
GTEX-OXRN-2626-SM-48TBX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.95293
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organelle part	GO Cellular Component Annotations 2015	1.0	null
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894714
CRCGN014_HEPG2_3H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24695
Spleen	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.1752
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05107
CTCF_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA1_MEL cell line_mm9_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18645
FLCN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00563555
SQ1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.56964
BRD-K93725829_ERK inhibitor 11e_HCT116_6.0_h_0.5_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LIG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00977088
PRC2_EDD_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GSE223008_7_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Rhizome	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.884
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311018
GSE146982_0_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pick body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.195
BRD-K73706189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58049
BRD-K39037393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5368
TRMT13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24779
A549_Panobinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0113561
Syndrome	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.541947
H3K23me2_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
6867_PSMD13_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.19851
superficial dorsofrontal area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55321
6847_PSMA7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.0841
Hand1::Tcf3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.3793
cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
PLCD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18119
BRD-K95558029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60457
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.873
BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6871_PSMD3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.4148
6453_PLK1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10374
GTEX-RWS6-0008-SM-47JYV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-K78238858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.75012
CYP17A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00734532
GTEX-TSE9-0011-R7A-SM-3DB7P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10784
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.486
GSE235066_4_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hypothalamic medial zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.16989
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.09869
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039553
Brain Lower Grade Glioma_LGG_TCGA-RY-A847-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Aril	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.68
7445_RPL21_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01363
lower (caudal) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10868
BRD-A45498368_WYE-125132_HS578T_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K03791970	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07338
Hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.935
1560_CHD4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.73733
BRD-K31834149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2029
Subthalamic nucleus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.125
GTEX-S7SE-0011-R6A-SM-2XCD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08416
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053619
CTCF_MCF-7_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.960082
5904_NUP98_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.07119
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.6202
areas	GeneRIF Biological Term Annotations	1.0	null
HNF4A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16485616_S1122_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ACP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00537941
GSE144231_6_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X4XX-0626-SM-3NMC1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907447
YAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14171
GSE202434,GSE202438_6_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Kidney Chromophobe_KICH_TCGA-KL-8339-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1874
POLR2A_cortical plate_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RXRA_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebral hemisphere	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.433374
Perturb_3838_KO_ITPR3_SRP361791	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.25443
hsa-miR-1915	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-K16485616_mocetinostat_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K72890304	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56568
valproic acid_homo sapiens_gpl96_gds1050	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8352-01A-31R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K81418486_vorinostat_HT29_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.796198
CRCGN013_HEPG2_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20753
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QEL4-0726-SM-3GIJ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.84465
Embryonic brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.172
BRD-K02558072_-666_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K82928847_rocilinostat_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DUSP11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00454568
BRD-K81418486_vorinostat_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
intermediate stratum of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.0169
Perturb_4558_KD_Prmt5_SRP126769	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.37589
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.51305
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.755551
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
9366_TSR2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.3711
BRD-K46639367	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77671
CC-17-HI11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.22278
9683_UTP18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1
HCC38	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.96114
UHMK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00649532
BRD-K91426044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20768
HLA-DQA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00782549
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.947505
GTEX-PLZ5-1726-SM-2I5F6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
AD-72-RI24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239021
GTEX-N7MS-0011-R1a-SM-2HMJG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19985
SLC4A11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00710292
periventricular stratum of r6Co	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36505
periventricular stratum of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.32707
mantle zone of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.239
GTEX-XUJ4-0126-SM-4BOP7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04853
UNC5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652879
hippocampus (hippocampal formation)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.26745
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.42184
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.634564
LY-294002-6976	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A18763547_-666_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE195568_3_v_10_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_12617_KO_PTPN2_SRP393040	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.60225
primary somatosensory cortex (area S1, areas 3,1,2)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.995576
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.837453
juxtaglomerular cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.306805
VZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1549
KLK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00630605
GTEX-WL46-0011-R2A-SM-3LK6O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72805
central gray of the pons, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10455
Perturb_987_KO_Eed_SRP092111	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.56035
Perturb_15999_KD_TP53_SRP261893	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
hypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.760742
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.001509
MYD88	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00694201
BRD-A61304759_tanespimycin_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
93T449	DepMap CRISPR Gene Dependency	1.0	3.32596
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960067
BRD-K87654551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06856
Perturb_5056_OE_MERVL_SRP161512	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.383
small intestine	HPA Tissue Protein Expression Profiles	1.0	1.18895
substantia nigra, compact part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.47842
Perturb_17282_KO_Hsf5_SRP345601	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
BRD-K08458391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.97551
HES2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60217
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.890521
TRIM28	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0051402
6605_PPAN_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.99526
MFM-223	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	3.15309
RGS12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00968351
BRD-K54384984	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06284
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4029
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0476
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06359
AB-12-IS33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.26041
Perturb_13190_KO_Wnt5a_SRP346437	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.81442
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.404
GSE239541_11_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of protein processing	GO Biological Process Annotations 2015	1.0	null
DA-35-DU85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.22991
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39766
Rhizophore	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.969
SAFB2_02_102	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.5329
lateral tuberal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.49258
LB771HNC	DepMap CRISPR Gene Dependency	1.0	11.8624
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.36819
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331002
BRD-K62810658_-666_PHH_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.17679
IGR1	CCLE Cell Line Gene CNV Profiles	1.0	1.69373
CTCF_MEL cell line_mm9_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU5F1-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RUNDC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11255
Breast Neoplasms	CTD Gene-Disease Associations	1.0	1.13586
MIN-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.763
amygdaloid complex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.28638
PMC12041165-401_2025_2886_MOESM1_ESM.xlsx-Meta_CAA_vs_AD-Genes_TSHZ1	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CW-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver Neoplasms	CTD Gene-Disease Associations	1.0	1.0766
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23431
H3K27me3_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157383_6_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
496100631_PCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.5122
CRCGN010_HEPG2_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32677
GSE158632_2_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TSPAN14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571056
choroid plexus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN014_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4599
Intrinsic component of mitochondrial membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.307
MAP4K2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00678215
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.85122
GTEX-QV44-2026-SM-2S1RD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-K56343971_vemurafenib_HS578T_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K95763144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1317
VAMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15697
BRD-K17140735_-666_TYKNU_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
spinal cord	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Pancreatic islet	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.673
Nucleus accumbens	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.214
Paraflocculus, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.37362
PPP2R5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00477718
BATF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00632818
Seizures	CTD Gene-Disease Associations	1.0	1.14713
brain	HPA Tissue Gene Expression Profiles	1.0	1.05935
CCL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00666189
ZC3H11A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZSCAN29	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7241
Perturb_4195_KD_Pqbp1_SRP018775	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.6409
GTEX-QDVN-2426-SM-2S1Q4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Cellular bud neck	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.079
GRIN2D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00449987
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02564
1441_CDK7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05876
BRD-K15025317_Bay 11-7821_H1299_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K50776152_cjd-pla-20-1_H1299_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
negative regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
Perturb_4955_KO_Zbtb2_ERP125291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.4237
GSE190384,GSE190386_3_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.534
GTEX-T6MN-0011-R2A-SM-32QOW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49676
BRD-K41859756_-666_DV90_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_5220_KO_Tdg_SRP171121	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.21242
MYBL2-22936984-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE79663_2_v_0_tcf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K68202742_trichostatin A_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Paramedian lobule, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31665
TXNDC12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593454
608_ATF5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14491
2732_ESPL1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06527
Lung adenocarcinoma_LUAD_TCGA-55-A48Z-01A-12R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSTK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00680614
GSE210101,GSE210114_8_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5504_NCL_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15547
A549_Panobinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0129478
F8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00737704
MLPH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00463103
301_ANAPC10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15224
striatum_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08716
GTEX-TSE9-0011-R5A-SM-3DB7J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29885
GTEX-WZTO-0011-R5B-SM-3NMC5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08857
GSE151364,GSE151366_1_v_2_taf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.22549
CA-75-HA22_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.30363
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
FB-39-CW59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.15274
MCF7_PD98059_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015808
Prostate adenocarcinoma_PRAD_TCGA-HC-7080-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD8A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00588713
ins-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.785635
TAF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0047556
BRD-K76401790_JNK-IN-5A_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pheochromocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.138
superficial stratum of DTTh	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18027
GTEX-RVPU-0011-R10A-SM-2XCAH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991867
6152_PDCD11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.87561
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5702-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13989_KO_Polr2a_SRP181107	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-15.2026
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
RNF166	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21321
HDAC2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A19037878_trichostatin A_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HA-22-CY42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.238621
AICD_Induced  expression / Over-expression_GDS1979_288_human_SHEP-SF neuroblastoma	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44632
7461_RPL34_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20028
BRD-K86797399_pracinostat_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Developmental disorder of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.378
BB-77-QQ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.396832
BF-10-IO69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.20459
Retrosplenial area, ventral part, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.48125
16455954-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GSTO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43703
NIX_Deficiency_GDS2630_160_mouse_spleen	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
FF-86-NH56_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.84839
THAP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.9405
AA-79-SX47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.225534
GSE217405_0_v_1_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K25147028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49332
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
decreased body size	MPO Gene-Phenotype Associations	1.0	null
7968_SLC16A5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00452
RPMI7951	CCLE Cell Line Gene CNV Profiles	1.0	1.59251
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965773
GSE214382,GSE214383_4_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TE-32-AC63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.560085
1893_CSE1L_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.55891
GTEX-Q2AG-0011-R8A-SM-2HMK5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25302
GTEX-TMZS-0226-SM-3DB9N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
r3 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-4.10739
BRD-K12841150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36508
GSE129293_0_v_1_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K77908580_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.220766
BF-22-EP86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.332173
olfactory tubercle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07435
within	GeneRIF Biological Term Annotations	1.0	null
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
Perturb_5638_KD_SOX2_SRP174102	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052474
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.12619
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rad17 RFC-like complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.955
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2IS-0011-R6A-SM-32QP2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04978
Perturb_5059_KD_Usp7_SRP235595	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.3801
9682_UTP15_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.94361
PDPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10627
BRD-K78373679_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-86-A4D0-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A6E7-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Autosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.051
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-A6M9-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6521_POLE2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11756
BRD-K44779670	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93122
5192_MRM1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25511
GTEX-WFJO-1026-SM-3GIKL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
7462_RPL35A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.23222
GTEX-U8T8-1426-SM-3DB9H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12432
Pituitary gland tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.846
H3K27me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-85-LB25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.402059
DMS454	CCLE Cell Line Gene CNV Profiles	1.0	2.59998
OAZ1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0047874
AE-04-SN76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247313
RCHACV	DepMap CRISPR Gene Dependency	1.0	2.17847
parkinsonismdementia	GeneRIF Biological Term Annotations	1.0	null
AC-30-XU83_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.668108
GSE195568_6_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11778
BRD-A68281735_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JUN_01_164	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	9.56339
Ventromedial hypothalamic nucleus, anterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22206
BRD-K88559334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08406
BRD-K51515697	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.58775
Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20163
7443_RPL18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.59721
primary motor-sensory cortex (samples)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01349
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A41199690	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45067
EIF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65759
EZH2_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00609006
GSE123372,GSE123373_10_v_2_mecp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.908253
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.909494
GTEX-QMR6-0011-R5A-SM-32PKT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833556
GSE150134_1_v_0_scn5a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.67903
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
PDK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00564226
BRD-K94301203	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06972
FABP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00703307
cytoplasmic part	GO Cellular Component Annotations 2015	1.0	null
BRD-K34519525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40435
RAD21	ENCODE Transcription Factor Targets	1.0	null
GTEX-T6MN-0011-R5A-SM-32QPD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29899
PPP1R1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00683612
MERO48A	DepMap CRISPR Gene Dependency	1.0	4.44163
PITX2_01_54	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	0.64267
BRD-K81418486_vorinostat_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Arbuscule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.858
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K57724551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20386
BRD-K59324446	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16004
6558_POLR3D_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01071
KA-51-CQ55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278916
HEPG2	BioGPS Cell Line Gene Expression Profiles	1.0	2.41625
Fibre tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.029
BLZF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00676365
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945489
GSE146982_3_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.989056
AB-18-YN11_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.252182
CASK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00565283
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.02787
PCID2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00832303
BRD-A62184259_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Delirium	CTD Gene-Disease Associations	1.0	1.15526
DBT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0496
DMD_Deficiency_GDS2996_613_mouse_Cardiac muscles from 8-week (mdx animals)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMC3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.41329
GTEX-XOTO-3026-SM-4B65M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55863
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932453
MCF7_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164336
GSE206870,GSE206872_0_v_2_ascl1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.31787
ALAS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00225475
GMPPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614761
AB-82-EP26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.502971
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
5163_MPHOSPH10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1832
GSE195559_3_v_1_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE205976,GSE205978_3_v_0_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
Axon cytoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.574
Mesothelioma_MESO_TCGA-MQ-A6BR-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skeletal Muscle Female	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.48522
KLF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	115.14
GSE193258,GSE193259_5_v_8_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Non-alcoholic Fatty Liver Disease	CTD Gene-Disease Associations	1.0	1.15189
BRD-K24565713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44066
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PIM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00513863
propranolol-3059	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RPL14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47017
CTCF_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF354C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0625
although	GeneRIF Biological Term Annotations	1.0	null
GTEX-SIU8-0426-SM-4BRUE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956571
endopeptidase regulator activity	GO Molecular Function Annotations 2025	1.0	null
PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Gene_name_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
LN-229	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.8645
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.346683
cytoplasmic vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Mammillary body	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24247
motor nucleus of trigeminal nerve, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.47616
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
DEFB106B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00739492
BRD-A77941182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18941
BRD-K61052964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14987
Perturb_4528_KD_Chaf1a_SRP060878	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.64213
BRD-A94377914_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Plant glandular hair	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.674
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19212
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5449_NAF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00817
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-QEL4-1426-SM-447AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.912774
ZNF682	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.3592
SAP30	ENCODE Transcription Factor Targets	1.0	null
LCK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00643601
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18814
AF-67-LZ82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.88875
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K81418486_vorinostat_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-RU72-0011-R2A-SM-2TF6O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883829
GSE240896,GSE240899_2_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4082364-supp_ddu111_ddu111supp_table14.xls-Tabelle1-Table_S14_comparison_MSC_WT1Wilms3_-_top_100_genes_down-regulated_vs_wtWT1_-_top_100_down-regulated_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
RAD21_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K00628863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84047
paraventricular nucleus, cap part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19581
5489_NCAPG2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20454
Major depressive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.097
Paraventricular hypothalamic nucleus, parvicellular division, medial parvicellular part, dorsal zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.06367
POLE3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00439956
primary motor cortex (area M1, area 4)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.93491
BRD-K69751974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89096
BRD-K79254416_decitabine_PC3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K22503835_Scriptaid_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
neuroblast	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063135
GTEX-T5JC-2526-SM-4DM6G	GTEx Tissue Sample Gene Expression Profiles	1.0	2.77625
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-K54330070_SB 202190_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AC-05-MR83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23111
9618_URB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14429
6963_PWP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.5295
Stigma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.47
cuneate nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.15147
BRD-K86797399_pracinostat_HEPG2_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
1545_CHAF1B_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06563
MDA-MB-436	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28326
CTCF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
danio	GeneRIF Biological Term Annotations	1.0	null
TCF3-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE106661,GSE106665_0_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
internal granular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03584
BRD-K81418486_vorinostat_COV644_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K69515345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05173
BRD-K65913831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52416
BRD-K12502280_TG101348_HCC515_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MFAP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0080092
Perturb_15488_KD_SIM2_SRP218853	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.40702
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1568
primary visual cortex (striate cortex, area V1/17)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.878812
single-multicellular organism process	GO Biological Process Annotations 2015	1.0	null
H3K79me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
abnormal emotion/affect behavior	MPO Gene-Phenotype Associations	1.0	null
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945489
Substance abuse	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.019
ITM2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00643715
homologs	GeneRIF Biological Term Annotations	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
6862_PSMC5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.61738
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.34804
GSE174701_1_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
response to abiotic stimulus	GO Biological Process Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-MO-A47P-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH727	CCLE Cell Line Gene CNV Profiles	1.0	1.42017
BRD-A59985574_T542500_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
ventrolateral part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.91358
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.654458
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-5668-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ventrolateral prefrontal cortex_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.989056
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.94904
BRD-U51024685_HG-6-64-01_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A854-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A728-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5112_KD_Med10_SRP325525	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.35404
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
6533_POLR1A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20471
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00624
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
WF-85-JN16_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.344192
GTEX-POYW-0726-SM-2XCEO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.949405
BRD-K09663164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00032
TRPC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0114503
GTEX-S3XE-2026-SM-3K2B5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
QA-25-HL62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.285771
GTEX-XAJ8-1026-SM-47JY9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08847
BRD-K90444258	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05796
NCIH1703	CCLE Cell Line Gene CNV Profiles	-1.0	-1.34899
16762588-Table2	GeneSigDB Published Gene Signatures	1.0	null
KLF9_Deficiency_GDS2703_647_mouse_Jejuna - intestine	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
9364_TSR1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1744
r10 part of nucleus gracilis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10681
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TEX14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623297
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A4XJ-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE139455_4_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HSD17B3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510182
BRD-A90643929_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
9804_WDR12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24265
metencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.750405
Secretory vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.083
GTEX-PWO3-0011-R5A-SM-2I5EZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861566
BRD-K16730910_regorafenib_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DE-85-FR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203749
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-orthofinder_human_gene_names_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.207
Kidney renal papillary cell carcinoma_KIRP_TCGA-UZ-A9PL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
negative regulation of proteolysis	GO Biological Process Annotations 2015	1.0	null
BRD-K99827210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2606
molecular layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08248
Adrenocortical carcinoma_ACC_TCGA-OR-A5L9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE241701_4_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
protein binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K00020149	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30392
GB-94-XG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214642
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07386
mantle zone of the Fc	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.48711
abnormal locomotor activation	MPO Gene-Phenotype Associations	1.0	null
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12552
NCIH1373	DepMap CRISPR Gene Dependency	1.0	4.90919
BRD-K95672029	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01208
LOXL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00461554
bed  nucleus of stria terminalis, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20707
BRD-K23280067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06306
GSE153836_11_v_2_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K67042874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03761
KARPAS1718	DepMap CRISPR Gene Dependency	1.0	2.00222
MAX	ENCODE Transcription Factor Targets	1.0	null
Trichome	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.323
GTEX-RU72-0011-R6A-SM-2TF71	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859018
BRD-K86797399_pracinostat_HT29_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K74701308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20613
DEF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.17436
5082_MIS12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.44851
BD-61-OO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209523
BRD-K28937085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04312
Mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
BRD-A72837804_7472-0056_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
lateral hypothalamic area, anterior region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.3184
GTEX-QVJO-0011-R4A-SM-2S1QL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913302
negative regulation of cellular protein metabolic process	GO Biological Process Annotations 2015	1.0	null
Crus 1, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.15328
ZNF543	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27062
BRD-K90527476	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35812
BRD-K44652223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45739
541_ARPC4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.49914
BRD-K86797399_pracinostat_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
kidney cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.129129
CALM1	Hub Proteins Protein-Protein Interactions	1.0	null
FA-65-UA27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243557
T47D	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.729031
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
superficial part of arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	3.77216
CC-68-YZ44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.620381
9679_UTP11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.49532
GTEX-S4Q7-0008-SM-3NM8A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857258
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.8645
frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Cingulate cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.17
9328_TRRAP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.48133
NEK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0053467
GTEX-XOTO-0011-R7B-SM-4B64R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51344
Myelencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.066
NLRC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00643282
EW7	DepMap CRISPR Gene Dependency	1.0	2.28539
glycopyrronium bromide-3427	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
lateral nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.63205
BRD-K89402302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32014
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.368
H3K27me3_cardiac mesoderm_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17743125_S1085_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00652458
GSE261563_3_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Posterior parietal association areas, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.05126
GTEX-XLM4-0011-R2B-SM-4AT5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1731
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ARRDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12099
Poisoning	CTD Gene-Disease Associations	1.0	1.2596
GSE210580_3_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-60-DR81_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211663
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
enzyme inhibitor activity	GO Molecular Function Annotations 2015	1.0	null
Malnutrition	DisGeNET Gene-Disease Associations	1.0	null
Perturb_5571_KO_RELA_SRP149723	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.36478
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_ensembl_gene_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
endopeptidase inhibitor activity	GO Molecular Function Annotations 2025	1.0	null
496100345_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.48927
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15951
biological_process	GO Biological Process Annotations 2015	1.0	null
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85256
BRD-K76840893_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T6MN-2626-SM-32PMQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04881
abnormal vertical activity	MPO Gene-Phenotype Associations	1.0	null
Psoas_Muscle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.26544
5729_NOC2L_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31281
GANAB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00558993
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.35
Retrosplenial area, ventral part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23685
BRD-K16485616_mocetinostat_HT29_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K65828139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61031
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Dorsomedial nucleus of the hypothalamus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.89253
GSE157684,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.831706
Tic Disorders	CTD Gene-Disease Associations	1.0	1.1198
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04482
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.37937
PPP3R2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00641564
urinary tract	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
UMUC3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43043
FBXW7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0064887
BRD-K81418486_vorinostat_MCF7_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE175787_4_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MHHNB11	CCLE Cell Line Gene Expression Profiles	1.0	2.01243
CRCGN016_MCF10A.WT.HP_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.081
BRD-K84450674_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11926
ChIP_SOX2_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-QDT8-0011-R3A-SM-32PKR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88519
LTB4R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00508892
MBNL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.010127
PMC9895410-Table_1.xlsx-Neuroendocrine_regulation_genes-TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K79551673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51877
Perturb_13700_KD_HEPACAM2_SRP257754	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.4256
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CA-68-KG29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.299763
MAT2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30571
BRD-K05392698	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25637
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.827772
BRD-K86899078_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
urinary bladder	HPA Tissue Gene Expression Profiles	-1.0	-1.06577
BRD-K71303366_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intermediate stratum of TSPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12128
basal ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.379499
abnormal fear/anxiety-related behavior	MPO Gene-Phenotype Associations	1.0	null
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.991554
Husk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.856
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
TUBB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0049708
BC-62-RZ55_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202843
BRD-K28122619	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54381
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.29062
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.415858
BRD-K67844266_MLN4924_OV7_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RHOU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545374
GNGT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00780984
REST_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.954763
GTEX-X261-0011-R6B-SM-4E3J8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11823
GSE190384,GSE190386_3_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE139016_3_v_2_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999408
FDPS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00417375
6033_PAFAH1B1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13786
CRB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00921712
DC-47-KV62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257195
H3K27me3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG-16518401-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K21680192_mitoxantrone_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE74251_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RFX5	ENCODE Transcription Factor Targets	1.0	null
LRRIQ3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00699164
DSTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53711
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-A89067742_HTS 10765_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
REST_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.05
H4K20me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4XX-0011-R3B-SM-46MWK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06445
BRD-K91564773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72147
BRD-K69840642_HDAC6 inhibitor ISOX_SW948_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AP-2rep	MotifMap Predicted Transcription Factor Targets	1.0	null
PRKAR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00347636
VZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.48907
GTEX-WZTO-0011-R4A-SM-3NMC7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16072
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-0011-R4A-SM-32QPG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824307
DKK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572983
4953_MED30_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31595
1747_COG8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.12821
Siphon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.512
GSE195786_0_v_2_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0707
Lung adenocarcinoma_LUAD_TCGA-62-8394-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AB-18-YN11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.477528
BRD-A94377914_-666_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.19183
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FAM98C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07402
LD-39-FL02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.323567
H4K20me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GPATCH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00557094
HCC2279	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5526
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K89626439_5284616_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Orbital area, ventrolateral part, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.51277
Brain Lower Grade Glioma_LGG_TCGA-HT-8012-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EGR3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.2879
KYSE-50	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93416
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
suprachiasmatic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.786052
lateral mammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30647
A549_Resminostat_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0122443
Perturb_15850_KO_Etv5_SRP165224	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	7.61687
GSE202434,GSE202438_15_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KLE	CCLE Cell Line Gene Expression Profiles	1.0	1.66673
BRD-K81418486_vorinostat_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intermediate stratum of r10BI	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0267
GSE148657_2_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K48235533	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00775
Perturb_6256_KO_CIC_ERP108370	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BRD-K71799778_BML-259_OV7_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IGF2R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00337778
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	1.0	null
Hypokinesia	CTD Gene-Disease Associations	1.0	1.03159
dorsomedial nucleus, terminal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.93801
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.59192
GJB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625691
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.908107
SIRT5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00786611
17009876-tableS1a	GeneSigDB Published Gene Signatures	1.0	null
BRD-K57226184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0431
2127_DDX51_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45419
OB granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09852
AtT-20 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	2.01
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.876272
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Catatonia	CTD Gene-Disease Associations	1.0	1.09506
KEAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00742558
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K65725294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87242
E2A_Deficiency_GDS5084_271_mouse_DN2 thymocyte	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
MYBPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06005
GE-77-FY84_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.527393
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NOTCH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00724529
BTNL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00675848
SALL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00596311
KMS18	CCLE Cell Line Gene Expression Profiles	-1.0	-2.0282
CRCGN015_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05265
Newcastle disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
GTEX-WVLH-0011-R5A-SM-3MJFW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15654
GSE182680,GSE182683_0_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cerebellar cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11761
MGRN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00816847
GTEX-XLM4-0011-R4B-SM-4AT5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40718
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CA-75-HA22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.405293
GTEX-WWYW-0011-R1A-SM-3TW8G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1359
GSE210580_0_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5889_NUP160_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.47618
10922_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25174
GTEX-V1D1-1026-SM-4JBHE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.910023
Corolla	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.3
BRD-K44139682	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38522
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Gene_Name_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
response to temperature stimulus	GO Biological Process Annotations 2015	1.0	null
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
signal transduction	GO Biological Process Annotations 2015	1.0	null
mediodorsal nucleus of thalamus_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.881142
FC-22-VC55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.331456
LLGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46559
Choline	CTD Gene-Chemical Interactions	1.0	null
PLK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566955
DA-80-IV36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266435
RDH14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00675586
TPM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00642793
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70A-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NEU2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00508278
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_PF-573228_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0142406
response to external stimulus	GO Biological Process Annotations 2015	1.0	null
benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041963
Communication disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.118
7559_RRN3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08527
OB-65-AI50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.415494
1844_CPSF6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15448
BRD-K13309514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06006
BRD-K77908580_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
decreased body weight	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K17743125_belinostat_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.51374
1206_CASP8AP2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01216
AE-39-DG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	2.23462
HDLM2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.51513
Pseudostem	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.677
PMC9232687-13238_2021_887_MOESM3_ESM.xlsx-37_KD_sgCDC20_vs_sgNTC-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.885151
ATP13A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00641039
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952746
amongst	GeneRIF Biological Term Annotations	1.0	null
7460_RPL32_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22229
BRD-K80690345	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46796
7795_SERF2_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.51928
6323_PIAS4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.30053
IL17RC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593388
Perturb_4816_KO_Apex1_SRP193096	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.49544
negative regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
MSX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08457
GTEx Ovary 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	9.76928
9820_WDR43_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.58805
H3K27me3_kidney epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ANXA11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49391
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SSTR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00541728
TXNL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13405
2132_DDX56_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13363
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.92209
BRD-K53855319_SRT-1720_HT29_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE234289_4_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Mesocarp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.63
KCNQ1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00607898
HD-29-LW24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.399959
GTEX-WHSE-0011-R3A-SM-3P5ZM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32864
7491_RPP30_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02386
GTEX-XLM4-0011-R7A-SM-4AT5L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42219
Perturb_4615_KD_Mlx_SRP231452	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.7247
BRD-K25340465_OSI-930_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.59
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16503
SAR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623599
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.57321
pituitary	GTEx Tissue Gene Expression Profiles	1.0	1.89319
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.23817
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.579837
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
BRD-K09602097_Forskolin_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6868-01B-12R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TM9SF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564301
Endocrine organ benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.243
CRCGN016_MCF10A.TP53.M_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58525
HIPK2_defectivemutant_17_GDS1793	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.92349
CRCGN016_MCF10A.WT.HP_24H:H16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45964
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9RC-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_13701_KD_NKX21_SRP335544	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.14583
DB-21-FY75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218188
CSAD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540349
BRD-K92011556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09796
EGR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	196.504
Bract	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.895
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.89568
8190_SMU1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03912
extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.786
IM9	DepMap CRISPR Gene Dependency	1.0	2.28016
BRD-K98431828	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64675
GTEX-WWYW-0011-R10A-SM-3NB35	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894297
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.23444
Secretory granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.998
CTCF_HCT116_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53308430_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
main axon	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.243879
BRD-K20259776	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35684
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K95294904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6319
GSE128076_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17742
SFRP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50597
Liver	GTEx Tissue Gene Expression Profiles 2023	1.0	1.39161
BRD-K81418486_vorinostat_PL21_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1336
PMC10794847-mmc2.xlsx-PBRM1_KD_up-Table_S1_Differentially_expressed_genes_with_PBRM1_knockdown_in_the_progenitor_state_Related_to_Figure_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K69840642_HDAC6 inhibitor ISOX_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RIT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00571697
BRD-K48717228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.28871
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.412712
SIAH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00370419
P4HB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618778
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-hsapiens_homolog_associated_gene_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-NPJ8-0226-SM-48TBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03071
GTEX-QVUS-2826-SM-3GADB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.931058
GTEX-POYW-1226-SM-2XCEP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09327
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
16166195-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
IMP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30929
Prostate adenocarcinoma_PRAD_TCGA-J4-A67M-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ChIP_TCF3_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GSE145990_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.421489
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
extracellular space	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Suprachiasmatic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.463
GAS6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00572221
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00881
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.848959
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE69244_1_v_0_j147_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
MCF7_Disulfiram_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150192
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4873-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K18447546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01362
GTEX-QCQG-2126-SM-2S1P8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
NFKBIA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00982751
Vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.197
VA-48-RJ44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.863083
Perturb_5201_KD_Wdr43_SRP132494	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.73712
7505_RPS16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	4.06785
ZNF263	ENCODE Transcription Factor Targets	1.0	null
CMK115	DepMap CRISPR Gene Dependency	1.0	2.80603
PSKH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00506247
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.733
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.965863
Nobox	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	14.5526
posterior (caudal) superior temporal cortex (area 22c)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18781
Gastrointestinal endocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.455
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27me3_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14200658_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K81418486_vorinostat_SNUC4_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K95196255_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.67513
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-05A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NPJ7-0011-R6a-SM-2I3G7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12597
GTEX-WL46-3026-SM-3LK7Z	GTEx Tissue Sample Gene Expression Profiles	1.0	2.37305
4945_MED22_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.19242
CCSER1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00634097
PLK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505873
BB-77-QQ71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.11072
GSE77108_4_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Retinitis pigmentosa 35	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.501
Stomach	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.079
outer portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.93868
FE-56-PV35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.15766
substantia nigra, pars reticulata, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.965988
GTEX-NPJ8-0011-R5a-SM-2HMJY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908587
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.12626
2235_DKC1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.60855
BRD-K83691318_1219-1259_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dosulepin-1713	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K94132559	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96918
BD-18-MM33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.47408
BRD-K03304013	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61905
CYP1A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00521439
GTEX-X4XX-3026-SM-3NMB2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854595
BRD-K15290974	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59186
RAB3GAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27884
Foot muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.746
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE98898_7_v_2_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO680N	DepMap CRISPR Gene Dependency	1.0	2.32028
BRD-K33770771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42208
SOX17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00948265
Crus I, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.979651
GTEX-XLM4-3026-SM-4AT6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12821
Weight Loss	CTD Gene-Disease Associations	1.0	1.34694
REST-19997604-NEURONS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.0509
Perturb_14982_KO_Setd1a_SRP330236	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.18747
BRD-U51024685_HG-6-64-01_MCF10A_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE231891_1_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.945489
GJA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00466497
7527_RPS5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.71072
BRD-K21680192_mitoxantrone_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE199606_5_v_0_ricin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Subiculum, dorsal part, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24115
LYAR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00625682
5933_OGT_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10448
excretory gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.062403
LYZ	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00418361
GB-01-UN23_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284395
6857_PSMC1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.6708
Gonadotrophic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.053
5114_MLLT6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10275
Perturb_8877_KD_ABCB6_SRP309466	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	9.45314
Branch	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.694
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.990127
Perturb_2126_KO_SUMO1_SRP299611	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	14.1015
arcuate nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.62542
superficial stratum of Mam	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.30647
MYC_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_7552_OE_IL1RN_SRP300901	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.41995
BRD-K78363521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5395
BRD-A84923154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89535
BRD-K27914478	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54935
trochlear nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.933083
calcium folinate-3442	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
S0-EE-YEKU_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.49303
GABRB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00620281
PMC7438927-Table_2.XLSX-upregulated_in_AA-Unnamed_2_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
9806_WDR18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11868
negative regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
NCCLMS1C1	DepMap CRISPR Gene Dependency	1.0	3.3453
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
NRG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00941775
GSE199255,GSE199356_6_v_1_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-TN-A7HI-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.209
response to cold	GO Biological Process Annotations 2015	1.0	null
BRD-K27721098_clopidogrel_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A45889380_QUINACRINE HYDROCHLORIDE_EFO27_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
8158_SMC4_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.36187
ACTR1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04388
KA-81-AG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271156
BRD-K31936306	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74875
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
8931_TINF2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.07645
estradiol-387	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-A491-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-V1D1-2626-SM-4JBJH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972487
5878_NUF2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.26652
KLRC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00858978
CRCGN015_MCF10A.WT.HP_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01633
Ventromedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59544
Nkx3-1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	16.4224
GTEX-QLQW-1226-SM-2S1Q9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
CTCF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K98595604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05147
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
brain ventricle	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2194
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13081
Alzheimer Disease	DisGeNET Gene-Disease Associations	1.0	null
GTEX-P78B-0726-SM-2S1O2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-K17753780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.70228
Perturb_6252_KO_Pcgf1/Pcgf6_SRP269225	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	16.057
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GATA3-27048872-CHIP-SEQ-THYMUS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
Preoptic area	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.484
7509_RPS19_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.67022
pontobulbar body	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.36925
Perturb_5295_KD_Smarcb1_SRP343414	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.43074
kidney	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.072752
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.895556
negative regulation of endopeptidase activity	GO Biological Process Annotations 2015	1.0	null
DD-42-PC65_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.297673
GTEX-P44H-0011-R10A-SM-2XCEK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857414
CTCF_MEL cell line_mm9_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P44H-0011-R5A-SM-2XCEX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936747
GSE212299_2_v_1_abi3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.025
MOG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00670786
GTEX-T5JW-1726-SM-3GADN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03217
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.914439
BRD-K98061543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20115
AE-85-KE62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.587472
ERB2_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
cytoplasmic vesicle	GO Cellular Component Annotations 2015	1.0	null
HNF4A	ENCODE Transcription Factor Targets	1.0	null
Perturb_5149_KO_Thap11_ERP126456	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.59479
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K36730085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43892
Urogenital Abnormalities	CTD Gene-Disease Associations	1.0	1.42293
Pancreatic delta cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.908
Accessory olfactory bulb, glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54647
exhibiting	GeneRIF Biological Term Annotations	1.0	null
periventricular stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08651
JURKAT	DepMap CRISPR Gene Dependency	1.0	3.92266
GSE202434,GSE202438_10_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.113
Asthma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.093
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19531
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9446
BRD-K81418486_vorinostat_SNUC4_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6844_PSMA4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.46804
NCVADR RES	BioGPS Cell Line Gene Expression Profiles	1.0	1.43209
Perturb_5045_KO_Sall1_ERP014607	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.275
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08245
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.0819
6858_PSMC2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.08639
GTEX-PVOW-0726-SM-2XCF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14006
SLC7A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00381101
GTEX-T6MN-2726-SM-4DM77	GTEx Tissue Sample Gene Expression Profiles	1.0	2.58215
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7UY-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UCK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0075724
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Anterior lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.589
PMC7862469-13238_2020_779_MOESM4_ESM.xlsx-FOXO3-GE_VS_WT-GeneID_FOXO3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K23481525	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00673
6843_PSMA3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.79472
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.725247
vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.465998
extracellular vesicle	GO Cellular Component Annotations 2015	1.0	null
BRD-K89110518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38631
DE-62-FI29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.547743
VZ in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03787
SEC14L4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.75322
FOXA2	ENCODE Transcription Factor Targets	1.0	null
PSMD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16377
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.34256
PMC6855629-pone.0225186.s003.xlsx-Sheet1-DEGs_repressed_by_MEIS1_in_human_cell_lines_MEIS1	Rummagene Transcription Factor Associations 2026	1.0	null
Rheumatic congestive heart failure	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
PMC9399107-41467_2022_32627_MOESM6_ESM.xlsx-20_T-cell_subsets-gene_name_CD8_C1_LEF1_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE210580_3_v_12_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CLEC6A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00830091
BRD-K55187425_ON-01910_MCF7_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WFG7-0726-SM-3GIKO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-K28565184	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3616
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.65
BE-65-HV88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.214405
MFSD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03877
Small Intestine - Terminal Ileum	GTEx Tissue Gene Expression Profiles 2023	1.0	1.1981
KDM6B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00653015
LGALS9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00612876
tc90	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.118
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.275038
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3407
PIFO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66907
EC-62-OE64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302664
ZD-85-ND87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24053
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE223008_9_v_2_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
6575_POP4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.6261
Right_Ventricle	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.12833
hippocampus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.405176
lateral part of MM	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19293
superficial stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6802
CTCF_BE2C_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IHH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.007059
GSE146982_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NB-12-ZK38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.388149
Germinated grain	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.966
DERL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19376
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-0326-SM-33HC4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20425
BRD-K86797399_pracinostat_MCF7_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T5JC-1526-SM-4DM68	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27478
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K39547688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15277
GTEX-S7SF-0526-SM-3K2BC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-K39863565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6334
Perturb_13275_KO_Zbtb24_SRP198761	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.69665
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.01998
JD-44-KF86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.320303
Field CA1, stratum lacunosum-moleculare	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.46543
Lateral group of the dorsal thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08651
Pars intermedia	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.482
TIFAB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00644706
Globus pallidus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.017
TMOD4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00553766
YMB-1-E	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34823
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.260107
IK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08442
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CD84	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00719836
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
MCF7_Tubastatin A HCl_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134157
CCL21	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00589413
3677_HEATR1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.33133
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
hsa-miR-3977	TargetScan Predicted Conserved microRNA Targets	1.0	0.336728
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.62541
DDX51	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00488539
BRD-K86797399_pracinostat_MCF7_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GALK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00499361
BRD-K64797043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90106
GSE231891_5_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
AQP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00708525
Perturb_8307_OE_GALNT3_ERP012063	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.46231
Pericarp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.783
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.18701
BRD-K85527716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35459
BRD-K00627859_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GM2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613699
GSE190384,GSE190386_2_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
CA-90-RU33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.324534
BE-31-XV38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.439794
9676_USP8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.26333
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
OVOL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00611445
BRD-K62982419_S1455_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CLN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1287
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15609977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.71471
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
AVPR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00751088
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
IRF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.6428
BRD-K81418486_vorinostat_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K60886324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52182
Movement disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
BRD-K76068355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17896
UF-27-HS98_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.37312
H3K27me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN013_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.59681
GTEX-P44H-0011-R8A-SM-2XCEL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965791
1301_CCDC86_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.57043
GSE198165,GSE198166_8_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EA-84-SC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288176
7507_RPS18_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.06966
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31503
Zic1::Zic2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	28.4929
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.08146
BRD-K97399794_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TKQ1-0226-SM-33HB5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16691
NUAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.006741
Purkinje cell layer of CbHCx	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.03391
BRD-K15280583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49655
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.981585
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZN-2626-SM-3DB7T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841445
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01859
NDUFB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00587832
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91868
BRD-K80782159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13368
GTEX-U3ZM-0426-SM-3DB73	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05848
RAD21_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100607_TCx_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.32642
GSE218949_0_v_1_cep20_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K40485332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12157
Enteroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.459
RAD21_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
H3K27me3_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AA-83-TW85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221246
BRD-K89853033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89372
CTCF_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
DNASE1L3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0084988
DC-51-WE27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.54483
ERF::NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.9331
PAK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00610074
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
intermediate part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.15929
core of P-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22206
BRD-K10707948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81907
midecamycin-2026	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.573616
BRD-K01436366_XMD-1150_SKBR3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.05648
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.956379
Fetal_Intestine_Large	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.915236
AA-99-HO76_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.829278
ROS50	DepMap CRISPR Gene Dependency	1.0	2.98321
anterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03211
JHESOAD1	DepMap CRISPR Gene Dependency	1.0	2.42422
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.861942
post-traumatic stress disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.22
Shu complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.857
GSE194268_2_v_0_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_8423_KO_DGAT2_ERP114849	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
LMCD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552505
GTEX-XOTO-0011-R5A-SM-4B657	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45926
CRCGN015_MCF10A.WT.HP_24H:K20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01494
BRD-K22229373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37497
CC-55-CD84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.258885
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29177
subarachnoid space	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
9816_WDR36_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24919
KLF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	182.057
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.51769
GTEX-S7SE-0011-R1A-SM-2XCDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10317
BRD-A61046366	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70665
OB glomerular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.11255
TRAPPC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52696
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	154.029
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
corpus callosum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.253908
LAPTM5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0095476
CTCF_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	136.491
Paraventricular hypothalamic nucleus, magnocellular division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.22774
BRD-K12994359_Valdecoxib_HT29_24.0_h_177.6_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE101537_4_v_2_neurog3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
REST_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SE-0011-R8A-SM-2XCDG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40466
HOXA13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00485813
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18781
Circumventricular organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.125
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-SOX2-Unnamed_6_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8329-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD81	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00563299
VZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22609
GTEX-P44H-0011-R4A-SM-2XCEW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.936241
CCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0058731
Lung adenocarcinoma_LUAD_TCGA-O1-A52J-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K60952519	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36584
Renal Insufficiency	CTD Gene-Disease Associations	1.0	1.27689
DSCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80065
8_AAMP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11678
BRD-K83300227	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49386
SLC28A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00544009
BA-77-US35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203127
primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.922821
Perturb_4818_KO_Neil2_SRP193096	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.61403
BRD-K88070218	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29836
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.612058
Crus 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.19899
esophagus	HPA Tissue Gene Expression Profiles	-1.0	-1.06577
CD-13-QZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.47107
CDH11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0127485
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OA-86-XP09_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.226045
hispanics	GeneRIF Biological Term Annotations	1.0	null
FA-52-OO58_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.348082
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
FNDC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4085
GSE228106_3_v_4_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
LGALS16	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582462
GTEX-RNOR-0011-R4A-SM-3GAD3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87546
GTEX-OHPL-0326-SM-33HC8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11525
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ezh2_deficiency_GDS2717_141_mouse_lymph node T cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
496100277_FWM_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.08802
Autosomal recessive disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.044
EIF3M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33754
KMT5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575313
Perturb_5244_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP275780	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.27649
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10Q-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K42247636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2164
BRD-K39944607_32937_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05439
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.3701
WPE1NA22	DepMap CRISPR Gene Dependency	1.0	2.30534
JURLMK1	DepMap CRISPR Gene Dependency	1.0	2.26667
mediodorsal nucleus of thalamus_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36435
dense core granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.250026
COL1A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598937
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.416
SIRPD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0075892
BRD-K79239947_PF 573228_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Motor neuron disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.145
anterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22591
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.07702
BCL11B_KO_GSE9330_4_mouse_brain (striatum)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
WC-82-YS26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.247369
496100569_TCx_possible Alzheimer's disease_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01388
GTEX-NL4W-0011-R10A-SM-2I3DY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873749
median nucleus of thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.390421
PMC11079006-41467_2024_48118_MOESM7_ESM.xlsx-E2F6_OE_vs_EGFP_CTR_DE-gene_E2F6	Rummagene Transcription Factor Associations 2026	1.0	null
brain	GTEx Tissue Gene Expression Profiles	1.0	1.08785
PMC5691083-41467_2017_859_MOESM6_ESM.xlsx-FDR_0_1_RELB_RNAi-Unnamed_1_RELB	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K52560704_methylstat_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K72359187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.38074
PML	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623202
LY-294002-6186	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K55612480_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Neural progenitor cell_Embryonic prefrontal cortex_Human	CellMarker Gene-Cell Type Associations	1.0	null
G292CLONEA141B1	CCLE Cell Line Gene CNV Profiles	1.0	1.6439
VZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1582
RAD21_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cisplatin_mus musculus_gpl339_gds3099	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-QESD-0008-SM-447B2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20479
MAPK14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0069255
MTTP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00863631
PMC12362115-mmc7.xlsx-S7-S7_Identification_of_proteomics_branch-specific_ATF6_targets_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K86797399_pracinostat_HEPG2_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
5902_NUP88_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22624
BRD-A60245366_AS-601245_A549_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.63685
332_ANKRD17_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15577
GSE96649_1_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K14306031	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36617
BRD-A19037878_trichostatin A_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AOB, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.30776
membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.588456
BRD-K49108064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08736
ARHGEF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00413156
Lung adenocarcinoma_LUAD_TCGA-91-8497-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03072
Ciliary neurotrophic factor receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.024
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.167366
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NUDT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00581391
Subiculum, dorsal part, stratum radiatum	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32983
GTEX-XMK1-1126-SM-4IHJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-A71816415_PRAVASTATIN SODIUM_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K53720386	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07556
GSE223893_11_v_9_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A19037878_trichostatin A_PL21_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KD-68-JH25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.367582
Human - Lung v1 - L2 - Neuroendocrine	HuBMAP Azimuth Cell Type Annotations	1.0	null
HCC2157	CCLE Cell Line Gene CNV Profiles	1.0	1.7631
membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CYP2S1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00596027
BRD-K30351863_NCGC00185090-03_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X585-0011-R5A-SM-46MVI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.85613
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
GSE217685_0_v_1_ddx20_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cytoplasmic membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
5550_NDUFAF7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.36372
Perturb_14677_KO_Prmt1_SRP153406	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
Pineal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.537
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.494877
IC-05-AW29_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29289
CTCF_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DOCK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0065752
Hypothalamus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.01529
BRD-K94058780	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56293
RING1B-27294783-CHIP-SEQ-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-QEG5-0326-SM-2S1PB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.59138
REST_Panc1_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7713_SDAD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.56234
GTEX-VUSG-2826-SM-4KKZM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03597
8594_SUPT16H_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0846
GET3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00472605
posterior hypothalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.997541
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157F_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
r6 part of dorsal cochlear nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.36733
NUTM2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00769869
medial preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13835
SLC10A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00677049
BCPAP	DepMap CRISPR Gene Dependency	1.0	2.3088
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.59405
BRD-A99750020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36043
GCT	GDSC Cell Line Gene Expression Profiles	-1.0	-1.46259
POLE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46165
mRNA_FOXP1_21924763	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
OVCA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00590036
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.45433
GSE162590_1_v_0_gsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
Neuro-2a cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.474
GTEX-PWOO-2326-SM-2S1PQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
paraventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.391553
MAP2K7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5999
Perturb_13254_KD_Ncaph2_SRP073037	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.21129
BRD-K82658511	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82692
PMC11749115-loae020_suppl_Supplementary_Table_S2.xlsx-CHOP-high-gene_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
Secretory granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.686
PMC9170821-JCMM-26-3183-s001.xlsx-Neu_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K14191038_JFD02227_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN010_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11595
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0086
ISLR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566189
BRD-K62248885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37712
PMC7064337-elife-51373-supp2.xlsx-847_genes_down-regulated-List_of_847_genes_down-regulated_after_PHF19_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
6576_POP5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13424
Brain Lower Grade Glioma_LGG_TCGA-S9-A7J1-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COX7A2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19565
Perturb_14681_KD_NKX22_SRP072566	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.27315
cell projection membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.116164
GSE119978,GSE180930_6_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFON-1826-SM-3GILG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19964
BRD-K66270896	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11761
BRD-K73451279	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60837
AOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0174
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_PCI-34051_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163502
RBBP5	ENCODE Transcription Factor Targets	1.0	null
GTEX-WZTO-0011-R1B-SM-3NMAR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.84024
OCIM1	CCLE Cell Line Gene Expression Profiles	-1.0	-1.61698
BRD-K98203492_GSK-J4_MCF7_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CLMP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00546683
BRD-K76921877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32869
BRD-A45140972_Meclocycline sulfosalicylate_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
adrenal gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.341495
IL17D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00803235
BRD-K36363294_I-BET151_HA1E_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.038
AE-39-DG66_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.272889
pituitary gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.11154
Collagen and cuticulin-based cuticle extracellular matrix	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.958
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.955121
Perturb_4815_KO_Neil2_SRP193096	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.56983
corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K51342021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43672
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K76450447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02666
CTCF_epithelial cell of proximal tubule_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE119498_0_v_10_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K14704318_7722075_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PRSS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00478422
SLC2A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00346441
BRD-K50423606	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04992
GTEX-XUJ4-1726-SM-4BONW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Amygdala	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.569
GTEX-X261-0011-R5A-SM-3NMB4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861085
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE169617_1_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.987706
NB-12-ZK38_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.243232
Prostate adenocarcinoma_PRAD_TCGA-HC-A6AS-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AKR1B10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00673293
Enteroendocrine cell_Intestinal crypt_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
Paraventricular hypothalamic nucleus, magnocellular division, medial magnocellular part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.25411
BRD-K92093830_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.626611
GTEX-S7SF-2226-SM-3K2BG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
GTEX-R55C-1826-SM-3GADI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01573
CALY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00764692
BCL6-25482012-CML-JURL-MK1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE139455_7_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nrf2_deficiency_GDS3406_156_mouse_liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Neuron_Brain_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
significant	GeneRIF Biological Term Annotations	1.0	null
GTEX-N7MT-0011-R10A-SM-2I3E1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13762
CE-23-HP88_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289142
GSE111035,GSE111040_8_v_9_plag1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
intermediate part of the arcuate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.04511
Uterine leiomyoma_Uterus_GSE2725	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.7998
CDH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00602122
PITPNM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00673767
single-organism process	GO Biological Process Annotations 2015	1.0	null
PMC4595011-pgen.1005555.s003.xlsx-BPTF_DOWN-regulated-Ensembl_gene_id_BPTF	Rummagene Transcription Factor Associations 2026	1.0	null
Salivary Gland Neoplasms	CTD Gene-Disease Associations	1.0	2.88009
HF-79-EC41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.470332
VZ in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.957542
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAP2K1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00487497
PMC7423359-abb8771_Table_S4.xlsx-Sheet1-Genes_detected_at_least_twice_in_h4E_BP1-hyperTRIBE_711_genes_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
HGC-27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.84478
pons	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.258917
BRD-K57251296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35969
GSE199255,GSE199356_4_v_2_pds5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25737009_-666_THP1_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HEL	DepMap CRISPR Gene Dependency	1.0	2.8818
Perturb_9699_KO_RNASEH2B_SRP355094	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80Q-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-10-SB73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.265839
intermediate stratum of PHyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.05501
BSN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0057755
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.3435
GSE179002_4_v_1_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
perimammillary part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.75969
SIN3A	ENCODE Transcription Factor Targets	1.0	null
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Subarachnoid space	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXM1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.966065
beclometasone-3001	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Pancreas-pancreatic pp cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.0842332
4954_MED31_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.61999
hippocampus (hippocampal formation)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.38035
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.849581
BRD-K83892314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28104
Stereotypic Movement Disorder	CTD Gene-Disease Associations	1.0	1.02077
6493_PNO1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01234
c2c12	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.38258
PANC1	DepMap CRISPR Gene Dependency	1.0	2.81166
VZ in ventromedial extrastriate cortex (VP)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23284
Podocyte foot	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.617
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.681064
BB-79-AG41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.274291
PPARD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00346022
C84	DepMap CRISPR Gene Dependency	1.0	2.00777
Perturb_375_KD_DHX16_SRP309315	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.0084
COV362	CCLE Cell Line Gene CNV Profiles	1.0	1.43164
BRD-K23556321	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30763
MCF7_Meprednisone_10µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139339
striatum_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03799
pick's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.772887
LRIT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00880457
TEDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4344
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.913
dorsomedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.62251
Mantle muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.245
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.57178
BRD-K47618355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44722
BRD-K16136457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21197
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3414
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
central part of MPO	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08096
BRD-K67860401_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
superficial stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.29187
BRD-K17743125_belinostat_HCC515_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K32403583_Mevastatin_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K36644177	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47054
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JF-62-LU77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257709
GTEX-T5JC-0011-R7A-SM-32PME	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24932
BRD-K49010888_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MNT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00460701
Diabetes Mellitus	CTD Gene-Disease Associations	1.0	1.03456
ZNF384	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
not applicable_Hypothermia_GSE54229_131_mouse_Embryonic fibroblas	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.8645
BATF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566423
BRD-K88806312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24939
Perturb_4166_KO_Bcl11a_SRP334609	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
BRD-K64536135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95361
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE120413,GSE120447_3_v_5_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC7439444-aba1972_Table_S9.xlsx-NR1D1_motif-Gene_Name_NR1D1	Rummagene Transcription Factor Associations 2026	1.0	null
HNRNPUL1_02_109	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.69661
H3K27me3_H7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
6850_PSMB2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.56367
BRD-K44427106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29398
HD-51-KD29_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234674
telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
VCAP	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51581
MS4A4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00749486
MIH complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.241
GSE174701_4_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_10_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X638-0008-SM-47JZ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-K30351863_NCGC00185090-03_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE100863,GSE100864_3_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Endocarp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
unique	GeneRIF Biological Term Annotations	1.0	null
EMD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00848899
CORL95	CCLE Cell Line Gene Expression Profiles	1.0	2.3932
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-QVUS-0011-R6A-SM-3GACX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07065
axon part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.095026
JDP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00650826
Field CA2, pyramidal layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.1886
BRD-K17743125_belinostat_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
2795_EXOSC8_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00621
IA-23-DB04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239436
NUTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23342
alvespimycin-6172	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AHR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00622
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AU565	CCLE Cell Line Gene CNV Profiles	1.0	1.40977
BRD-K49010888_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K36196444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01585
FUT4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559997
WNK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00624344
primary visual cortex (striate cortex, area V1/17)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.900129
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05258
8405_SRFBP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31047
CIITA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00638952
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.976
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.789
MAP3K11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0103804
Perturb_14919_KO_Polr2a_SRP181107	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.86404
BRD-K37890730_Camptothecine (S,+)_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
x1/5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.844
UM-UC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.3744
7468_RPL37_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25886
BRD-A99518825_STOCK4S-23872_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-A10330754_7815359_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYDGF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00651066
PSMD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00856459
inner portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.53837
Lateral myocardial infarction	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.03
Perturb_9515_KO_Sall4_ERP111723	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.39718
BRD-K31856043_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A28219573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41242
CRP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00578269
BRD-K47869605_-666_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE242555_1_v_0_fn3k_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
8744_TBRG4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.2577
BRD-A84695402	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76276
BRD-K19958830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.47547
single	GeneRIF Biological Term Annotations	1.0	null
BRD-K94489736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13316
GTEX-R55G-0426-SM-48FDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865351
BRD-K80738081_resveratrol_PC3_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ASPM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00510775
16397240-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
BRD-K81418486_vorinostat_HCC515_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WHSE-0011-R7A-SM-3P5YZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15525
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIHA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.824766
BRD-K77908580_entinostat_HT29_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Chromaffin cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.056
embryonic brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.449886
TC-YIK	GDSC Cell Line Gene Expression Profiles	1.0	2.72082
BRD-K58247702_NCGC00183913-01_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K51556300_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CHMP4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23742
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	142.971
LEF1_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of PHyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.67511
BRD-K60476892_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K19652287	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33335
REST_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12844
GSE206870,GSE206872_1_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206870,GSE206872_3_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MICALL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00755987
H1 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.1482
BRD-K76942055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23022
BRD-K24471810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16171
globus pallidus, internal segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03273
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.977966
Lateral visual area, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.32536
H3K4me1_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cerebral cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.438356
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
GTEX-T5JC-0011-R4A-SM-32PLT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04815
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.777
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.342
Exocarp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.617
MXI1	ENCODE Transcription Factor Targets	1.0	null
TH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497778
BRD-K39526528	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.91627
BRD-K75128590_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cloning	GeneRIF Biological Term Annotations	1.0	null
KLF5	JASPAR Predicted Transcription Factor Targets	1.0	null
CRCGN008_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25465
SCNN1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00761258
5732_NOL10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01767
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.8497
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-7.66093
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.168101
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05681
Hematuria	CTD Gene-Disease Associations	1.0	1.03046
P2RX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00607748
RUNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51059
TIPIN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00560044
CE-15-YU05_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.366117
VZ in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05192
BRD-K63068307_ZSTK-474_HME1_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ethanol_rattus norvegicus_gpl341_gse1996	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MALL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0116508
primary somatosensory cortex (area S1, areas 3,1,2)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.948663
brain	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.824431
BRD-K63410075	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74213
1348_CCT4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1961
SIGLEC9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00713371
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.23776
Breast lobular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.359
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.25226
BRD-K04791118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03806
ADRA2C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0100516
Bone inflammation disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
Nephridium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.817
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-N7MS-0011-R5a-SM-2HMK8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09581
CD200R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00977898
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.675476
GSE209938_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WC-16-IR43_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.904947
GSE188870,GSE188871_1_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FADU	CCLE Cell Line Gene CNV Profiles	1.0	1.85968
BRD-K08558441	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14502
Perturb_13851_KO_RET_ERP126468	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE216988,GSE216989_0_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ANKMY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18761
GTEX-WHSE-0011-R6A-SM-3P5ZP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2518
BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K12867552_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
471_ARHGAP6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15375
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05107
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1941
BRD-K61494613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03125
GTEX-N7MT-0011-R8a-SM-2I5GU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.834572
primary motor-sensory cortex (samples)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.890521
NTRK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00457295
NCIH2110	CCLE Cell Line Gene Expression Profiles	-1.0	-1.60492
BRD-K45399554_CAM-9-027 BRD-K45399554_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K81418486_vorinostat_LOVO_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
7536_RPS6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.38509
MCF7	BioGPS Cell Line Gene Expression Profiles	1.0	0.913559
GSE162892_3_v_1_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K73293050_S1170_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
2792_EXOSC5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00098
GSE175787_8_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
DIP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17694
GSE175787_4_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Retrochiasmatic area	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.12698
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15419
MIM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.819
Lateral posterior nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.55763
BRD-K79159743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29666
SLC66A1L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00860598
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.102
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7439574-13148_2020_914_MOESM2_ESM.xlsx-log2_fold_change_-2-1280_genes_are_more_than_four-fold_downregulated_in_PRDM8-_-_compared_to_control_PRDM8	Rummagene Transcription Factor Associations 2026	1.0	null
LIPC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00893685
GSE119978,GSE180930_3_v_4_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.67847
CEBPB	ENCODE Transcription Factor Targets	1.0	null
GSE234289_5_v_0_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4QS-0326-SM-2I3EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.824285
BRD-K81142122_STK249718_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AC-44-UR36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.27185
SMYD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551459
Spinal column	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
IL7R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00696752
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K16485616_S1122_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOLR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00519174
Lung squamous cell carcinoma_LUSC_TCGA-37-4141-01A-02R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23062
abnormal body size	MPO Gene-Phenotype Associations	1.0	null
VZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23783
BRD-K01166365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55757
LXF-289	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.895556
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.845585
BTN3A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524631
etiocholanolone-2204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
SH2B3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00440124
posterior (ventral) nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.61637
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956352
SMC3	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
midbrain raphe nuclei, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.835088
RARRES1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00607725
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11778
BRD-K43359161	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2564
extracellular vesicular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
decreased total tissue mass	MPO Gene-Phenotype Associations	1.0	null
496100317_FWM_no dementia_no TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.57407
striatum_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.12421
Iliac artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.819
BRD-K68705041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37207
striatum_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49106
NCI-H1373	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.00631
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.979668
FB-32-PY27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.306332
SR	GDSC Cell Line Gene Expression Profiles	-1.0	-1.55547
GTEX-QDT8-0426-SM-32PKZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942246
SLC4A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620518
GSE102505_1_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCOA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00707809
TUBA4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00489824
GA-04-JM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.387949
GTEX-RWS6-0326-SM-2XCAP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03551
7508_RPS19BP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.39539
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.63126
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DB-41-IH69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.224685
BRD-K46119789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04988
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.344
BRD-K22503835_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
rectum	HPA Tissue Protein Expression Profiles	1.0	1.18895
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.24396
SUM-44PE cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WVLH-0011-R8A-SM-3MJFC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18075
FGF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00782195
BRD-K19862308	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53784
intermediate stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.18233
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.30717
Corticotroph tumor cell_Kidney_Human	CellMarker Gene-Cell Type Associations	1.0	null
disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.4443
NCSTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22683
ITGAE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00392073
PMC6379364-41598_2018_37489_MOESM2_ESM.xlsx-Sheet2_DESeq_MSC_vs_fibroblast-DESeq_MSC_vs_fibroblast_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
IFRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49028
7607_RUVBL1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04754
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5771
neuron	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.573217
HB-06-WU12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.628279
cerebral lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.337072
Diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.096
NUCKS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00390802
Spinal Cord Diseases	CTD Gene-Disease Associations	1.0	1.02671
GTEX-XMD1-0011-R2B-SM-4AT5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835102
QA-07-KC40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.302939
GTEX-R55E-0011-R8A-SM-2TC66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0886
Calyx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.549
BRD-K41731458_TRICLOSAN_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SIGLEC12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0071155
Breast lipoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.331
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.435216
1478_CENPC_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24643
PARK7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056838
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.267
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.3562
external granular (germinal) layer of lower rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.57084
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78O-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27me3_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11361
4108_IMP4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.14054
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7503_RPS15A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.33046
BRD-K02526760_QS 11_WSUDLCL2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDAC6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00363225
BRD-K69528787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07823
carbohydrate metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.281153
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
496100362_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.43
LAMA-84	GDSC Cell Line Gene Expression Profiles	-1.0	-1.56937
VMRCLCD	DepMap CRISPR Gene Dependency	1.0	2.01621
BRD-A19037878_trichostatin A_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
5699_NKX6-1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15647
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	119.449
BD-38-QC39_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.26564
superficial stratum of AOB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.2496
7434_RPL12_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.46667
JF-96-HH81_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.362093
BRD-K46942548	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28504
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
corpus striatum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.303559
GSE139348,GSE139349_1_v_0_dicer1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
5909_NVL_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01595
ELK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00948149
GSE130401_4_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE232218_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
KSR2_knockout_60_GSE17923	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.21482
DRD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00531461
IL12A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00702313
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89891
BRD-K47865468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74961
GTEX-S4Q7-0426-SM-3K2BJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934967
Skeletal muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.197
LHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18486
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.311789
GK_KO_GDS2610_162_mouse_Brown adipose tissue	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
RAF1_overexpression_220_GSE42964	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.53126
BRD-K08408085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31607
BRD-A62025033_temsirolimus [CI779]_NCIH596_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE113817_0_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-97-BI36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.60703
CDKL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00720143
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
4384_KIF20A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.15838
GTEX-UJMC-0526-SM-3GAE3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.850804
BRD-K41220170_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K63787803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48225
BRD-K02130563_S1030_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K33098168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.89162
CRCGN015_MCF10A_48H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05016
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Eye-cd8-positive, alpha-beta t cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.164575
FAM193B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4909
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell surface receptor signaling pathway	GO Biological Process Annotations 2015	1.0	null
AB-92-GP61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.32033
Kidney renal papillary cell carcinoma_KIRP_TCGA-F9-A7VF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K84401063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18926
PMC9537523-41467_2022_33364_MOESM7_ESM.xlsx-scores_wilcoxon_1_MONTH_ORG-EN1_n_EN1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K72335238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13871
GTEX-QDVN-1626-SM-48TZC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00086
BRD-K81801123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10953
periventricular stratum of PO2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1527
GSE238018_3_v_0_mxra8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Habenular trigone	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.71
PHB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44215
GTEX-O5YT-1826-SM-32PK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907314
BRD-K43240808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13164
SNU119	CCLE Cell Line Gene CNV Profiles	1.0	1.33894
CTCF_A549_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.821
BRD-K42496940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30873
BRD-K12343256_trametinib_HS578T_3_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-FC-A8O0-01A-41R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
secretory granule	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
dorsal motor nucleus of the vagus (vagal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.983328
JUND_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHGB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23067
MAST3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00641424
Midbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.029
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01679
intermediate-density lipoprotein particle	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.606
Exosporium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.502
BRD-K23860926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13278
mantle zone of THyB-V	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89013
BRD-K17245631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44798
Pancreas-pancreatic beta cell	Tabula Sapiens Gene-Cell Associations	1.0	4.29543
RIPK4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2737
posteroventral (inferior) parietal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.837089
Coma	CTD Gene-Disease Associations	1.0	1.42967
extracellular vesicular exosome	GO Cellular Component Annotations 2015	1.0	null
MERO14	DepMap CRISPR Gene Dependency	1.0	2.22448
Psychotic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.133
CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA	ChEA Transcription Factor Targets 2022	1.0	null
leading edge membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.451631
BRD-K04628654	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02318
DA-27-BW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284079
vesicle	GO Cellular Component Annotations 2015	1.0	null
SK23	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27405
regulation of hydrolase activity	GO Biological Process Annotations 2015	1.0	null
GTEX-SNMC-1326-SM-2XCFK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Stomach Smooth Muscle	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.1354
GTEX-Q2AG-0426-SM-2S1PU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.46636
WNT9B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063785
Perturb_13222_KO_Hdac3_ERP123505	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.80538
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.11775
IGFBP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00586863
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.256028
BRD-K81418486_vorinostat_SKM1_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Perturb_14939_OE_hPRDM15_SRP182668	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.75298
PMC12498101-cd-24-1904_supplementary_tables_s1-s12_suppst1.xlsx-S7-Supplementary_Table_7_Human_tissue_RNA-seq_differential_analysis_for_SPOPmut_vs_SPOPwt_AA_vs_AG_and_AG_vs_GG_clone_data_DEG_set_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
KNS42	CCLE Cell Line Gene Expression Profiles	1.0	1.74297
core of T-DMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.76086
cerebellar cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39733
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
their	GeneRIF Biological Term Annotations	1.0	null
NCIH650	CCLE Cell Line Gene CNV Profiles	-1.0	-2.20312
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_skin fibroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
cytoplasm	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Amygdala	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.10356
Perturb_9659_KD_SOX11_SRP306591	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.46661
5869_NUDT21_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.61476
BRD-K67734449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29469
SOBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495536
3568_GTF2B_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.52172
REST_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K64642496_-666_HT29_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MMP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18568
Subparaventricular zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.1612
GA-51-DD14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205144
Perturb_14397_KD_XPR1_SRP347870	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.53467
EOMES	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00718121
AOB, outer plexiform layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22233
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Upregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27me3_fibroblast of lung_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Filgotinib_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136942
SNU5	CCLE Cell Line Gene CNV Profiles	1.0	1.59741
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hexamethonium bromide-4965	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
appear	GeneRIF Biological Term Annotations	1.0	null
Mitotic fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
BRD-K20755323_-666_PC3_24.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Breast Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
2551_EIF3G_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21268
BRD-K68676343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19452
GTEX-QV44-2226-SM-447A3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
mantle zone of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.59109
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.21
BRD-K48501991	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0423
BRD-K02719847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18841
GTEX-NPJ8-0011-R6a-SM-2HMKB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20786
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.857107
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.948876
CEBPB-22108803-LS180-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Mycolate outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.669
GTEX-QVJO-0011-R9A-SM-2S1QH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21856
SKBR3	CCLE Cell Line Gene CNV Profiles	1.0	1.4842
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.200922
6860_PSMC3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.4021
NUGC-3	GDSC Cell Line Gene Expression Profiles	-1.0	-1.53447
BRD-K64606589_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
AC-36-TL21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.495666
PMC8986528-41586_2022_4598_MOESM6_ESM.xlsx-Fig_4h-LAS1L_KD_upreg_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K39499927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25391
Folium-tuber vermis (VII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.37186
OV-MZ-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.78
1842_CPSF3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10833
pcs	GeneRIF Biological Term Annotations	1.0	null
Leaf base	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.448
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11452
BRD-K68667113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01258
Zymogen granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.641
KCNC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00636333
Perturb_5340_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP337936	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.65923
PMC7438927-Table_2.XLSX-upregulated_in_AA-Upregulated_in_AA_Log2FC_3_Adjusted_P_value_0_01_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GHSR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00637903
BRD-A36630025_-666_SNUC5_6.0_h_0.35_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
digestive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K56334280_S1367_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K38003476_Clocortolone pivalate_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.297
Hypothermia	CTD Gene-Disease Associations	1.0	1.15695
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72383
CHPF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00821298
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
molecules	GeneRIF Biological Term Annotations	1.0	null
gemfibrozil-1430	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE90552_1_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K51364219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3418
NFATC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559521
Perturb_4049_KO_Pde1b_SRP260102	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.55186
GTEX-VJYA-1326-SM-3GIJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Heart Diseases	CTD Gene-Disease Associations	1.0	1.10527
7506_RPS17_ENST00000330339.7	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31285
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3091
SUPM2	CCLE Cell Line Gene CNV Profiles	1.0	1.84759
GSE128333_2_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K99824630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29648
Brain Lower Grade Glioma_LGG_TCGA-DU-A5TR-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12903452-mmc5.xlsx-ST2-2_OCT4_Off_Targets-Target_Gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.32017
trans-golgi network	GO Cellular Component Annotations 2015	1.0	null
5089_NIFK_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.70763
600MPE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.975964
HAO2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00770527
DLG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15489
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Supraoptic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.056
BRD-K49577636	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83632
CRCGN009_HEPG2_24H:E05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.37664
cortex of cerebellar hemisphere	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08446
ALOX12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00576819
CYP11A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627113
GA-28-SS67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.230578
GTEX-UTHO-3126-SM-3P5ZB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87753
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EIF4EBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82517
hypothalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.735559
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21387
Perturb_5004_KO_Rinf_SRP200002	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.4459
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	176.813
Perturb_2817_KD_SASH1_SRP231434	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7026
cterminal	GeneRIF Biological Term Annotations	1.0	null
IL10RB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0047808
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889181
PKN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0081082
Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J1-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PC14	CCLE Cell Line Gene CNV Profiles	-1.0	-1.92864
BRD-K12867552_-666_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CHD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00340745
preoptic region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.26613
MAGI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00796166
GTEX-T6MN-0011-R7A-SM-32QP5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45088
PMC8901773-41598_2022_7986_MOESM3_ESM.xls-T_vs_LPS-Gene_symbol_ENSEMBL_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
NR1H4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.57946
1350_CCT6A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03727
BRD-K77908580_S1053_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
vinpocetine-1557	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X585-0011-R3B-SM-46MVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20063
BRD-K97256018	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38648
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.575046
Perturb_2125_KO_AMBRA1_SRP288295	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.91033
Methionine	CTD Gene-Chemical Interactions	1.0	null
A549_Quisinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.017076
Paraflocculus, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.91561
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9311
SUDHL1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.77779
EP300_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LYSP100-associated nuclear domain	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.717
BRD-K24598235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27117
Lung adenocarcinoma_LUAD_TCGA-49-4510-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A6C6-01A-21R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE89032,GSE89033_0_v_1_sfpq_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Substance-Related Disorders	CTD Gene-Disease Associations	1.0	1.07199
VZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.986583
BRD-K67868012_PI 103 hydrochloride_NCIH508_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PLA2R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0051069
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-2526-SM-3GILR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
JHH-7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.84478
DGCR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.53445
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PM-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
nucleus accumbens, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.867834
GABPA_01_113	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.51761
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.665306
SUPM2	DepMap CRISPR Gene Dependency	1.0	3.09512
BRD-K87964538_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K76713927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37578
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-3026-SM-3NMA2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.4685
ISG15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00779184
DB-88-VW47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.356584
GTEX-RVPV-0011-R5A-SM-2TF69	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24918
BCL2L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00535323
MDA-MB-361	GDSC Cell Line Gene Expression Profiles	1.0	1.6238
UFSP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00525608
AA-11-RO46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.817665
GSE193258,GSE193259_5_v_1_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
7516_RPS27A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.89661
PITHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13607
PSMB8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00360011
Sepal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.223
7438_RPL14_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.64723
spinal nerve	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.311507
TE5	CCLE Cell Line Gene Expression Profiles	-1.0	-2.03562
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.12167
anterior (rostral) cingulate (medial prefrontal) cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.3268
stereotypic behavior	MPO Gene-Phenotype Associations	1.0	null
6887_PSMG4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19823
SGK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00708567
6869_PSMD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.22048
Nanog_KD_GDS1824_134_mouse_embryonic stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K75514760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18542
Muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.197
SRP54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48618
MCF2L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00617346
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Tuberomammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.27456
GA-94-MC54_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.979211
1841_INTS11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.27005
regulation of protein metabolic process	GO Biological Process Annotations 2015	1.0	null
ARHGAP25	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00526053
7521_RPS29_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.29305
POU5F1-18700969-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
PFKFB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00535013
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.18321
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.523693
Crus 1, molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.24115
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kmp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.723
PMC12198892-pi-2025-0101-Supplementary-Material.pdf-20-NR1H2_NR1H2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K13094524_PFI-1_HCC515_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mRNA_EOMES_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
BRD-K11911061_-666_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K37720887_SB-525334_PC3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
AF-12-IW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.775151
HOXD9_01_70	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.58646
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
BRD-K70518736	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14198
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
PMC11991920-41556_2025_1639_MOESM3_ESM.xlsx-DEGs_MI_vs_Ctrl_HSCs_padj0_1-gene_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_86_KD_EZH2_SRP377669	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.80755
HPGDS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00656908
GBP7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00399106
abnormal body weight	MPO Gene-Phenotype Associations	1.0	null
GSE198165,GSE198166_6_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
7519_RPS28_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.0378
GTEX-NL3H-0011-R6a-SM-2I3G8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08036
BRD-K12502280_TG-101348_MCF10A_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K45495792	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35709
BB-87-SF89_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.286967
inclusions	GeneRIF Biological Term Annotations	1.0	null
DE-34-DT75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264077
PMC9795333-mmc4.xlsx-HUES66_Ex_SATB2_c1_c4_c9-X-linked_genes_SATB2	Rummagene Transcription Factor Associations 2026	1.0	null
molecular function regulator	GO Molecular Function Annotations 2015	1.0	null
8651_TAF10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.30095
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.80922
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.30909
PYCR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540889
RELA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520934
9824_WDR46_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.30681
BRD-K62698674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38992
TEAD4-22529382-TROPHECTODERM-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R8A-SM-32QP3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48043
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29009
GPD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00988511
MYBL2-22936984-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
IFNB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00738555
fenspiride-1422	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCCC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00698353
metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K88936403	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64632
BC-56-CP81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.690814
PMC11383936-41598_2024_71738_MOESM6_ESM.xlsx-DEPS_LMS_vs_LMS_--Unnamed_4_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K92241597_CHR 2797_PC3_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MDA-MB-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00362
EPHB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00445958
EFO21	CCLE Cell Line Gene CNV Profiles	-1.0	-2.00399
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A6-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
BRD-U64521890_XMD16-144_HCC515_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HUH7	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
Pneumonia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
BRD-K78310215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7566
abnormal eye morphology	IMPC Knockout Mouse Phenotypes	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_7491_KD_MLLT3_SRP174861	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.2147
SURF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24453
BRD-K12089436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3411
BRD-K84439371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13771
H3K27me3_cardiac mesoderm_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03829970_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC1143	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86392
GSE101537_1_v_3_neurog3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.115221
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	230.357
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC366	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32703
BRD-K43473008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.96355
GSE130690,GSE130692_1_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PON1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00710413
TOV112D	CCLE Cell Line Gene Expression Profiles	1.0	1.70097
GSE153836_14_v_1_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K93788137_PF-431396_SKBR3_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
gracile nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.39794
BRD-A62809825_-666_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.97757
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09837
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K16937802	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22291
paraventricular nucleus, dorsal part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.13269
VEZF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.4201
RAD21_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
shikonin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15252
POU5F1	ChEA Transcription Factor Targets	1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.59845
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.877
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-A634-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IB-33-TE51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.737122
BE-42-IC00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.257002
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
A549_Belinostat_1µM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.01449
orbital frontal cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.900129
scoulerine-2891	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF740	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	235.384
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.14962
BRD-K07361992	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22651
GSE148252_7_v_6_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100380_FWM_no dementia_no TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.25214
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LB-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.281153
Skeletal system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.197
mRNA_POU5F1_16767105	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
BRD-K16485616_mocetinostat_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0049231
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26833
TM6SF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00653255
OR10V1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0077681
INS-1E cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.623
GTEX-RVPU-0011-R5A-SM-2XCAD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869444
RPRD1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00032
dorsolateral prefrontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.59318
BRD-K55187425_ON-01910_MCF7_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K18822985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15083
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC10015223-can-22-1444_supplementary_data_2_suppsd2.xlsx-K2-ATF3_peaks_Context3-Nearest_Ensembl_ATF3	Rummagene Transcription Factor Associations 2026	1.0	null
AE-18-ZM98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.321362
PMC2263127-pone.0001816.s002.xls-Terms_with_Genes_E2F3_up_Bild-Title_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE80537_3_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-01-DO31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.246192
basal part of terminal hypothalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.71243
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-A19037878_trichostatin A_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954092
BRD-A48237631_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SLC4A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494194
GSE218580_1_v_0_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
5746_NOP14_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.95269
Nervous System Diseases	CTD Gene-Disease Associations	1.0	1.12082
Lung adenocarcinoma_LUAD_TCGA-49-4490-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
Gynoecium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.498
VCaP	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.76144
5901_NUP85_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02512
RHOXF2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58328
SGS cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.981
2124_DDX47_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.19704
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.751
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.24233
stomach_3b	HPA Tissue Sample Gene Expression Profiles	1.0	0.9753
THY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00533794
Ventral posteromedial nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22446
BRD-K46161579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34418
BRD-K59761766_6,6-dimethyl-3-(methylthio)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid MAY_6_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
r1 roof plate	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.97489
CTCF_WERI-Rb-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
19838208-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GTEX-S32W-1926-SM-4AD63	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05576
PMC11669947-JCSM-16-e13672-s001.pdf-56-ZBTB7C_ZBTB7C	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRP-2426-SM-2S1NR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	633.455
BRD-K69840642_HDAC6 inhibitor ISOX_SKM1_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-SUCS-0326-SM-32PLL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
VCP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5716
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5884-11A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Memory Disorders	CTD Gene-Disease Associations	1.0	1.54475
GSE206729_4_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE146156_2_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26442
FF-86-NH56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.555341
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.19825
GTEX-RU1J-0126-SM-2TF6Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Eye-erythroid lineage cell	Tabula Sapiens Gene-Cell Associations	1.0	-0.163518
ventromedial hypothalamic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.31928
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ALPK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00514516
peptidase inhibitor activity	GO Molecular Function Annotations 2025	1.0	null
CC-49-CQ25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.270662
hsa-miR-555	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
Neoplasms, Experimental	CTD Gene-Disease Associations	1.0	1.04501
limbic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.9118
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.704
Prelimbic area, layer 2/3	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.13498
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Type 2 diabetes	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.830103
DE-73-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.23081
RFX5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Dacinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130299
Neural Tube Defects	CTD Gene-Disease Associations	1.0	1.2352
PPIP5K1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00544231
MTF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.5056
PMC8514013-bloodcandisc-2-450-s007.xlsx-FOXP3_mRNA-Unnamed_2_FOXP3	Rummagene Transcription Factor Associations 2026	1.0	null
MYC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00531121
ARSK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.0095
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14812927	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28564
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-0.973218
BRD-K07005393_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.206
MCF7_Valproic acid sodium salt_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141407
EZH2	ENCODE Transcription Factor Targets	1.0	null
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K65860773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.40989
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ventrolateral preoptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.19581
Perturb_13276_KO_Dicer1_SRP226863	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	1.0	0.98189
PMC11383936-41598_2024_71738_MOESM6_ESM.xlsx-DEPs_LMS_vs_LMS_-_vs_HC-Unnamed_4_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.58132
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.705037
A549_Zileuton_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159821
1365_CD3EAP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1443
Tuberculosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.164
FE-29-XM40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.201711
BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K69241192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51137
CRCGN008_HEPG2_24H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.38415
TEAD4	ChEA Transcription Factor Targets	1.0	null
tonsil	HPA Tissue Gene Expression Profiles	-1.0	-0.836053
BRD-K22970494	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51551
HC-19-UZ81_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202225
SERPINB8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0055977
GSE92457_9_v_10_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QF-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNRPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28187
GSE133763_0_v_2_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL11B_KO_GDS3178_296_mouse_striatum	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
OC-10-FB51_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.350104
BRD-K81932943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76596
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.852348
mantle zone of TPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03508
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.0599
CTCF_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CYP3A7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00765044
GTEX-T5JC-0011-R5A-SM-32PLK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18704
Neuroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.772
BRD-A79768653_sirolimus_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Intrinsic component of mitochondrial inner membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.308
BRD-K91282650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02059
IL12RB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00583829
BRD-K81418486_vorinostat_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
496100484_FWM_no dementia_no TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33446
5302_MTBP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.24827
PK1	DepMap CRISPR Gene Dependency	1.0	4.44277
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.46681
H3K27me3_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SLC22A6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543712
Periventricular hypothalamic nucleus, posterior part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.11551
binding	GO Molecular Function Annotations 2015	1.0	null
gracile nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38852
BRD-K07013504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80656
GAD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00570228
GTEX-Q2AG-3026-SM-48U1L	GTEx Tissue Sample Gene Expression Profiles	1.0	2.34373
BRD-K86797399_pracinostat_MCF7_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE157555,GSE157556_5_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
wortmannin-389	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SRSF2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00917955
mRNA_NIPBL_20720539	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
COLO 800	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46598
alpha-estradiol-6970	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5891-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Posterior lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.822
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.847662
GSE242290_3_v_7_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.907558
Habenula	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.828
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z2-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Dense core granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.73
GSE163862_2_v_3_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MTG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09139
BRD-A39193201	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39819
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09931
ATP1A4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621664
ALDH18A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32839
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.966425
GTEX-QVJO-0011-R5A-SM-2S1QM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.839221
ALDH6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6401
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
7568_RRP9_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.28658
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
LF-94-HB11_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.721851
CRCGN016_MCF10A.TP53.M_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21047
7450_RPL23_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.20438
Prostate adenocarcinoma_PRAD_TCGA-J4-A67N-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DA-35-DU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.768108
SU-DHL-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.56004
AB-97-BI36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.10169
RELB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01838
NCIH1618	CCLE Cell Line Gene Expression Profiles	1.0	1.52007
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.38384
MPZL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00603099
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.898083
MCF7_Daphnetin_10µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161226
17850661-TableS4	GeneSigDB Published Gene Signatures	1.0	null
Kidney Chromophobe_KICH_TCGA-KM-8639-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12209767-bcd-25-0099_supplementary_table_s2_suppst2.xlsx-C_DEGs_RNA-seq-Supplementary_table_S2C_List_of_differentially_expressed_genes_in_IGHUND_vs_IGH_GCB_MB2_DE_DLBCL_HGBCL-DH-BCL2_-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K98451611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54208
Epilepsy, Tonic-Clonic	CTD Gene-Disease Associations	1.0	1.01062
H3K27me3_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-95-YQ95_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240692
CLEC4G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00862838
Paramedian lobule, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02069
SOX2	ChEA Transcription Factor Targets	1.0	null
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.44469
PMC4082364-supp_ddu111_ddu111supp_table9.xls-Tabelle1-Table_S9_MSC_WT1Wilms3_-_top_100_genes_down-regulated_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K94544211_-666_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K67146164	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55228
BRD-K56196992_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JVE015	DepMap CRISPR Gene Dependency	1.0	2.54828
NID2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03299
SAOS2	BioGPS Cell Line Gene Expression Profiles	1.0	0.858852
NCAPD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09701
VIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06121
Periodontosis	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
DPP7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00476122
GSTM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00810494
BRD-A40639672_KETOROLAC TROMETHAMINE_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.524974
CF-24-KQ98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.284508
DDX24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	5.28557
GTEX-XLM4-0011-R10A-SM-4AT5P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34417
Lung adenocarcinoma_LUAD_TCGA-L9-A444-01A-21R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PSMB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00739032
RXF393	GDSC Cell Line Gene Expression Profiles	-1.0	-1.60866
LU-134-A	GDSC Cell Line Gene Expression Profiles	1.0	1.47621
gallamine triethiodide-1375	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K60635455	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67711
hippocampus (hippocampal formation)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04229
GTEX-NPJ7-0008-SM-4E3JS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09074
BRD-K34700473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.34444
8873_THAP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.3118
BRD-K81288338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08394
7163_RBM19_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.62098
REST_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VD-76-SO91_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.33054
MPEG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00940753
striatum_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.55407
Lewy body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.066
thiamphenicol-glycinate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75741
amygdaloid complex_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12698
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.996934
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12467
ChIP_NANOG_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
PPP1R14B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00691239
GTEX-WEY5-1926-SM-3GIL8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
LGMN	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00477106
Cerebrovascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.361
POLR2G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08992
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.227
BRD-K68558540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84862
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.87247
BRD-K31851742_7695534_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K84677391_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bonemarrow	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.27793
NAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00592645
H3K27me3_BJ_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051707
GTEX-NPJ8-0011-R7a-SM-2HMJV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85538
terminal subparaventricular area of THyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10117
DANG	CCLE Cell Line Gene CNV Profiles	-1.0	-1.44365
conserved	GeneRIF Biological Term Annotations	1.0	null
H2AC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39217
PFDN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551762
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5UM-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Abexinostat_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0072257
CENPK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09777
GTEX-QVJO-0011-R8A-SM-447C7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81087
GSE171352_2_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FC-62-AI14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.204433
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
6861_PSMC4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.66673
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BD-18-MM33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.07485
PFDN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00448521
CHRNB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00509054
Exopher	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.825
MCF7_Maraviroc_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148973
Amygdala	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.444
10995_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19181
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22213
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A6HP-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
pancreatic alpha cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.326432
GSE210580_5_v_7_rag2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.03215
BRD-K86574132_-666_HT29_24.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Prelimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02825
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14508
thalamic nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.308612
Intrinsic component of organelle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.233
DB-01-BR68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.334328
PMC12764576-41467_2025_66371_MOESM3_ESM.xlsx-INSM1_signature_gene_list-Supplementary_Data_1_INSM1_signature_gene_list_INSM1	Rummagene Transcription Factor Associations 2026	1.0	null
EZH2_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00905253
kidney_c	HPA Tissue Sample Gene Expression Profiles	1.0	0.949597
organonitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
H3K4me1_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE42805,GSE42811_2_v_3_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
MLKL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00632136
REST_PFSK-1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351513
1742_COG3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.108
Dorsal premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.2396
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
Primary somatosensory area, lower limb, layer 1	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54875
Kibra-Ex-Mer complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.88
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE84148,GSE96938_0_v_2_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81418486_vorinostat_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TCF3	ChEA Transcription Factor Targets	1.0	null
AC-30-XU83_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210867
protein metabolic process	GO Biological Process Annotations 2015	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
superficial stratum of THyB-D	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.43642
BRD-K93123848_RAF 265_HEPG2_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
715_AURKB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.7701
thalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.228764
5733_NOL11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.75798
ABCC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00462934
CTCF_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MTHFSD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2963
BRD-K44713204	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.49285
2313287	CCLE Cell Line Gene Expression Profiles	-1.0	-1.67589
G43417UB	GlyGen Glycosylated Proteins	1.0	null
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894979
Lingula (I)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.48516
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A43N-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC5798892-41421_2017_3_MOESM8_ESM.xlsx-down-regulated-Supplementary_Table_S3_Up-_and_downregulated_genes_in_ATF6-_-_hMSCs_compared_to_ATF6_hMSCs_late_passage_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K65729622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00754
GTEX-QDVN-0126-SM-4GIC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08678
RPS6KL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00462255
Hyperkinesis	CTD Gene-Disease Associations	1.0	1.07093
RCOR1	ChEA Transcription Factor Targets	1.0	null
mRNA_RAD21_21589869	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.957131
Micronuclei, Chromosome-Defective	CTD Gene-Disease Associations	1.0	1.09047
Perturb_4603_KO_Mst_SRP246200	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.54047
3447_GNL3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.06371
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13562
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K48056188	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38853
DNAJC5G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00547931
BRD-K90874005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28799
GPR19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87317
AC-36-TL21_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.37591
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.10985
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923454
BRD-A79768653_sirolimus_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K87418410	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37521
CTCF_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-N7MT-1026-SM-3TW8T	GTEx Tissue Sample Gene Expression Profiles	1.0	2.1968
GTEX-XLM4-0011-R6A-SM-4AT4B	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60964
BRD-K97309399_THIOTHIXENE_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K27me3_BJ_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76318449	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20895
Nucleus of the solitary tract, commissural part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.10399
GSE225762_1_v_0_pcmt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81418486_vorinostat_SW948_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SPATA2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41234
Pick's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.406
BRD-K61213827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12367
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.58305
Perturb_7601_KO_ALKBH3_SRP064738	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.6449
BRD-K09499853_KU 0060648 trihydrochloride_NCIH596_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K68202742_trichostatin A_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Status Epilepticus	CTD Gene-Disease Associations	1.0	1.06406
GABPB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00807961
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316184
IGSF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00931158
BRD-K61661017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1924
abnormal body composition	MPO Gene-Phenotype Associations	1.0	null
GTEX-QVUS-0626-SM-447CC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923453
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.424581
OF-47-EQ74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229948
BRD-K68178119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29837
PCYT1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00731166
Histone locus body	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.1
GTEX-RNOR-0011-R7A-SM-2TF4V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891008
DDAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34827
PMC11067031-pnas.2317690121.sd06.xlsx-gene_list_14_txt-Differentially_expressed_genes_between_PML_RARA_GFP_vs_C88A_PML_RARA_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.08512
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE184892_6_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K81418486_vorinostat_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MCTS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49044
CCRF-CEM cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.929
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE235066_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DPEP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00653352
BRD-K65257143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30925
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.529626
GSE195743_1_v_4_lhx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE226584,GSE226589_1_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Infralimbic area, layer 2	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44105
BRD-K72125659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01728
GSE148252_5_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FU97	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26442
16166195-Table2a	GeneSigDB Published Gene Signatures	1.0	null
mesalazine-6162	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Median eminence	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.918
Bronchial disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.18
Kidney Chromophobe_KICH_TCGA-KN-8433-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K96288607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11115
BRD-K13301506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40929
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.873278
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4193_KO_Mbnl1_SRP057123	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.64902
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_id_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Myosin phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.553
CMK115	CCLE Cell Line Gene CNV Profiles	1.0	1.73131
abnormal duodenum morphology	MGI Mouse Phenotype Associations 2023	1.0	null
juxtaglomerular apparatus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.241746
H3K27me3_cardiac mesoderm_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K93817456	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64637
IRF5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00880978
BRD-A89337244_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC7895828-41419_2021_3488_MOESM3_ESM.xlsx-Sheet1-Supplementary_Table_3_List_of_deregulated_genes_in_c-MYC_altered_human_HCC_from_TCGA_LIHC_dataset_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922969
BRD-K33164466_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
10703_ZNRD1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.58753
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K81418486_vorinostat_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K18620798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95812
reticular nucleus of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.980842
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SLC43A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00451319
H3K27ac_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21065
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-GV_RFX-Unnamed_3_RFX1	Rummagene Transcription Factor Associations 2026	1.0	null
ALDH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34174
lysosome	LOCATE Predicted Protein Localization Annotations	1.0	null
ZC3H12C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00496784
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-7269-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202933_1_v_0_ugt2b28_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.146
ROS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00571533
BRD-K24681473_S1130_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K84932026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83109
6119_PCF11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.3082
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-HNF4A_HNF4A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13824
TRA2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623815
GSE138841_0_v_1_trim6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101239_5_v_6_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.915173
globose nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24591
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GZ-05A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer portion of medial ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.72968
response to dietary excess	GO Biological Process Annotations 2015	1.0	null
TXLNA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58797
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27776
5731_NOC4L_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.17741
RCOR1-19997604-NEURONS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K78599730_manumycin A_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
response to nutrient levels	GO Biological Process Annotations 2015	1.0	null
IGSF9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00697262
FOXM1	ENCODE Transcription Factor Targets	1.0	null
DCBLD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.76917
BPI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00599276
RFX7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8611
PTEN_DN.V2	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
Central lateral nucleus of the thalamus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07263
Perturb_6234_KO_Mecp2_SRP045354	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	14.175
MPZL3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0063333
Hypertension	CTD Gene-Disease Associations	1.0	1.32876
CRCGN015_MCF10A_48H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.44768
Vomiting	CTD Gene-Disease Associations	1.0	1.05089
PMC10510228-13287_2023_3481_MOESM7_ESM.xlsx-DEGs-Differentially_expressed_genes_DEGs_in_bone_marrow-derived_MSCs_from_six_human_donors_cultured_at_high_confluency_MSC-HC_versus_low_confluency_MSC-LC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Paraventricular hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.08096
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.846281
HIF1A_01_86	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61363
lateral hypothalamic area, tuberal region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.00632
10040_ZCCHC9_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.2729
abnormal locomotor behavior	MPO Gene-Phenotype Associations	1.0	null
GSE153867_6_v_3_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
C4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00479728
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.829076
xenopus	GeneRIF Biological Term Annotations	1.0	null
GSE144231_4_v_7_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05833
BRD-K32644160_UZI/1930680_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ICC108	DepMap CRISPR Gene Dependency	1.0	2.49991
CD300LG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0110278
BB-87-SF89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.429897
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.17019
PMC11511861-41420_2024_2216_MOESM2_ESM.xlsx-siTAZ_myc_bound-MYC_targets_from_chipseq_atlas_at_least_2_chip-seqs_over_4_in_A459_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9181267-mmc3.xls-FILTERED_OLD-INFvsYOUNG-INF_LUN-GSEA_name_TOPORS	Rummagene Transcription Factor Associations 2026	1.0	null
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pituitary gland tumor cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.734
Brockmann body	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.574
HDAC2	ENCODE Transcription Factor Targets	1.0	null
BRD-A19037878_trichostatin A_A375_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ATM_knockdown_18_GDS1852	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.83025
BRD-K33653343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27004
SKMES1	DepMap CRISPR Gene Dependency	1.0	2.51574
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TSE9-0011-R9A-SM-3DB7Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908936
YMB-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34823
BRD-A19037878_trichostatin A_EFO27_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ARHGAP30	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0133037
6846_PSMA6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.53325
endopeptidase inhibitor activity	GO Molecular Function Annotations 2023	1.0	null
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.956284
Pituitary	GTEx Tissue Gene Expression Profiles 2023	1.0	2.15096
BRD-A45889380_QUINACRINE HYDROCHLORIDE_OV7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CCRT CEM	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.37118
NCIH1568	CCLE Cell Line Gene CNV Profiles	-1.0	-1.46134
CACNA1F	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0069968
GSE228261_0_v_1_elesclomol_human	RummaGEO Drug Perturbation Signatures	1.0	null
superficial stratum of PCPD	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.54647
H3K27me3_cardiac mesoderm_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.7759
ASGR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490105
BRD-K70154746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95956
BRD-K63242692	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13869
KNS81	DepMap CRISPR Gene Dependency	1.0	2.17257
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.381
negative regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
regulation of biological quality	GO Biological Process Annotations 2015	1.0	null
BRD-K75224334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07382
FKBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03969
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K35960502_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08492
DPEP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00585653
EIF2AK4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00482387
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A85I-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11573765	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18101
BRD-A19037878_trichostatin A_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PC-68-DU31_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.619355
BRD-K21568472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55922
PRKCI	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00902324
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TCOF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05393
TD-48-XJ84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.233076
MCF7_Altretamine_10µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0140191
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-RORC_mod_RORC	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_cerebellum_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GNAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00616245
BRD-K12867552_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE119498_6_v_4_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	103.55
GSE182680,GSE182683_0_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
KS-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48406
BRD-K22599787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14497
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.6924
GLYATL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00619998
CHP212	CCLE Cell Line Gene Expression Profiles	1.0	1.70649
abnormal lung morphology	MGI Mouse Phenotype Associations 2023	1.0	null
BRD-K69932463_AZD-8055_BT20_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE157555,GSE157556_0_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S3XE-0426-SM-3K2AC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6945-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TOP1MT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00597068
Tepal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.441
MCF7_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143644
BRD-K10404799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16813
GTEX-WZTO-2926-SM-3NM9I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07623
APUD cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.457
Syncope	CTD Gene-Disease Associations	1.0	1.06116
BRD-A19037878_trichostatin A_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Anxiety disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.499
BRD-K31908823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.28477
BRD-K75900952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.155
GTEX-OHPN-0011-R5A-SM-2I5FF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14138
GTEX-XMD1-0011-R5A-SM-4AT47	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01226
H3K27me3_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911972
Paraventricular hypothalamic nucleus, magnocellular division, posterior magnocellular part, lateral zone	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.20163
BRD-K35424586_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IB-56-JN40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355579
TRIM28	ENCODE Transcription Factor Targets	1.0	null
BRD-A19037878_trichostatin A_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
substance-related disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.055
NCIH2141	CCLE Cell Line Gene Expression Profiles	1.0	1.66724
SJRH30	GDSC Cell Line Gene Expression Profiles	-1.0	-1.4284
Perturb_4510_Mut_Tip60_SRP081300	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.79661
GSE190186,GSE190188_0_v_10_apoe_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of molecular function	GO Biological Process Annotations 2015	1.0	null
6043_PAK1IP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.19627
Adenohypophysis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.598
GTEX-RU72-0011-R8A-SM-2TF61	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35143
Lung squamous cell carcinoma_LUSC_TCGA-43-7658-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6215_PELP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.61134
JHOS2	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
HSPE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25621
CTCF_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCA1_Knock-in_GDS3544_562_mouse_Cerebellum - 12 Weeks	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
RAD21_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCHR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00930157
Leaf axil	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.664
PNKP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00951787
OB olfactory fiber layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.23264
Copula pyramidis	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.02445
Ovary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.927853
BRD-K41878930	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6266
mediodorsal nucleus of thalamus_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.844522
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JA-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
decreased anxiety-related response	MGI Mouse Phenotype Associations 2023	1.0	null
WARS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00923087
CMK	CCLE Cell Line Gene CNV Profiles	1.0	1.40229
1918_CSTF3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.51121
SP1	ENCODE Transcription Factor Targets	1.0	null
PMC10107781-NAN-49-0-s002.xlsx-NGS68_MBNL2_KO-vs-WT_log2FC0-4-symbol_MBNL2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K81029756_L-cis-DILTIAZEM_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
STK11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00497771
Coronavirus infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.889
arcuate nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.25577
RAB17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12093
RORC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00671463
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_16498_KO_ZFP36L1_SRP373359	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Perturb_8422_KO_DGAT2_ERP114849	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
6548_POLR2G_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1663
Fibromyalgia	DisGeNET Gene-Disease Associations	1.0	null
4164_IPO7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.21258
Parkinson's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.365
ANP32B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06395
IL23R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00823125
cellular nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
RBM22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36586
kidney cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.077632
VZ in subgenual cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.86815
BRD-A58955223_L-sulforophane_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25135
H3K27me3_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRPV6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00613663
ZNF567	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.85197
INSM1_KO_GDS5066_472_mouse_pituitary gland	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
GSE212312_1_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	1.0	null
TP53_DEPLETION_GDS4070_451_human_MDA-MB-231 breast cancer cells (depleted of MUTANT-p53)	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K69775722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00234
BRD-A19037878_trichostatin A_RMUGS_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K34335352	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80586
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42442
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1941
BRD-K89784888_2339-2182_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HTR7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00400235
Moh	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.541
4959_MED9_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.01959
GTEX-X261-0011-R8A-SM-4E3I5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.59499
primary somatosensory cortex (area S1, areas 3,1,2)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71142
NCI-H446	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.05142
GSE111660_4_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.295691
CE-95-YX02_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.26015
ZBED2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.0301
Carpel	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.484
PMC11239565-uxae032_suppl_supplementary_data_s1.pdf-25-ZNF513_ZNF513	Rummagene Transcription Factor Associations 2026	1.0	null
CFHR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00843897
CE-23-HP88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.215011
Cingulate gyrus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.17
Perturb_4960_KO_Dot1l_SRP214101	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.43662
BRD-K74311661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2366
EOMES	ChEA Transcription Factor Targets	1.0	null
cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.537731
Speech Disorders	CTD Gene-Disease Associations	1.0	1.03456
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TC-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MMP28	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0069966
CTCF_A549_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.907
Perturb_4521_KO_Mapk1/Mapk3_SRP281895	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.69754
serine-type endopeptidase inhibitor activity	GO Molecular Function Annotations 2015	1.0	null
Anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.229
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Human - Lung v1 - L1 - Neuroendocrine	HuBMAP Azimuth Cell Type Annotations	1.0	null
PQBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07896
BRD-K62193937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04515
16474848-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
4522_LARS_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.27367
CHRM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00442442
A549_Dacinostat_1µM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169262
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4822-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Obesity	DisGeNET Gene-Disease Associations	1.0	null
CRCGN011_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3429
PMC8387919-mmc2.xlsx-ST6_NEUROG3-KO_downreg-Unnamed_4_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
ETS2_KD_GSE62168_259_mouse_mouse trophoblast stem cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
MM253	DepMap CRISPR Gene Dependency	1.0	6.05046
inner portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.01575
BRD-K68595406	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.189
ATP2A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00325155
7467_RPL37A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.76568
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.898368
DPH5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494407
fourth ventricle	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.223419
Perturb_9653_KD_HAND1_SRP306591	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	18.1079
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Perturb_4709_KO_Hesx1_ERP023509	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.35216
BRD-K10989739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17176
Hemispheric regions	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.08651
GTEX-TSE9-0011-R4A-SM-3DB7H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05054
GSE146982_0_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CB-32-EI69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.645444
PDCD10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00644464
DC-51-WE27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.419303
BRD-K82324807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33242
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.94629
Parkinsonism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.035
SLC38A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0053567
Perturb_4814_KO_Neil1_SRP193096	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.28944
BRD-K94518115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16943
LY75-CD302	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00746867
gata1_15860665_megakaryocytes_lof_mouse_gpl1261_gds1245	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.190574
CEP170	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0106187
JUND	ENCODE Transcription Factor Targets	1.0	null
Copula pyramidis, granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09852
8963_TMA16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.28682
BRD-K71345532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41774
supraoptic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.907523
9684_UTP20_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.27171
GTEX-N7MT-0011-R6a-SM-2I3G3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17844
5903_NUP93_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	3.11265
PMC11627398-pone.0315219.s005.xlsx-MTF1-symbol_MTF1	Rummagene Transcription Factor Associations 2026	1.0	null
Prefrontal cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.612
TTK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00386591
GSE216273,GSE216292_14_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE149035_7_v_0_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A13122391_16-HYDROXYTRIPTOLIDE_MCF7_24.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
area postrema	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.92069
Idoxuridine_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00879918
GTEX-N7MS-2625-SM-3LK77	GTEx Tissue Sample Gene Expression Profiles	1.0	2.86143
Perturb_1088_KO_Perk_SRP370072	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.93723
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.10647
central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.403811
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.766744
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
superficial stratum of OB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.10054
FD-91-OK66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2643
capillary	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.288514
GSE128076_1_v_3_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Habenular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.71
terminal hypothalamus (rostral hypothalamus)	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.47027
Hemorrhage	CTD Gene-Disease Associations	1.0	1.22664
BRD-K86838462	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.93096
CFP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00854731
BRD-K70158474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17213
8161_SMC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1861
CYB561D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00586284
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_epithelial cell of proximal tubule_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ProSAAS	InterPro Predicted Protein Domain Annotations	1.0	null
Flower bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.981
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245297
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.495
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GMPR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00460569
ERMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65967
Perturb_5228_KO_Dnmt1/Dnmt3a/Dnmt3b_SRP194961	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.7348
Hypertrophy	CTD Gene-Disease Associations	1.0	1.24244
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A767-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD320	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0039353
perifornical nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28673
CRCGN008_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2726
Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A84U-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Stolon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.607
periventricular stratum of PPaA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.14411
diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.04005
LRP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.55914
OFD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00548268
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.827506
tubocurarine chloride-2887	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
DGKH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00755542
skeletal system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.059798
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-K74148702_curcumin_THP1_6.0_h_48.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN011_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.09915
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.158
BRD-K90675978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39301
BRD-K46056750_AZD-7762_HS578T_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IA-27-CK10_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.231365
CD46	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540887
NB10	DepMap CRISPR Gene Dependency	1.0	4.60326
NCIH2009	DepMap CRISPR Gene Dependency	1.0	2.47617
accumulate	GeneRIF Biological Term Annotations	1.0	null
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.28
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.427
Erectile Dysfunction	CTD Gene-Disease Associations	1.0	1.02896
QB-42-MC63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.743511
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14768
HIF1A_01_224	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	1.14419
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056487
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
spinal column	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.399871
7439_RPL15_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.34264
central nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.89647
GTEX-Q2AG-0011-R5A-SM-2HMJH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29394
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.22566
ATP5F1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03247
negative regulation of catalytic activity	GO Biological Process Annotations 2015	1.0	null
GTEX-XOTO-0011-R1B-SM-4B65C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67324
PRKAG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568716
BRD-K82785545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11041
8078_SLC39A7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.44873
frontotemporal dementia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.897461
Perturb_4817_KO_Neil1_SRP193096	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.93253
fastigial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.78028
BRD-K17743125_S1085_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MOCOS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00495267
Human - Fetal Development - L2 - Pancreas-Islet endocrine cells	HuBMAP Azimuth Cell Type Annotations	1.0	null
GSE217132_0_v_1_pfkfb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
medial subdivision of central nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11765
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
ZNF324	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05507
BRD-K93337444	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31297
RXRA	ENCODE Transcription Factor Targets	1.0	null
GTEX-QDVN-0326-SM-2I3FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05609
BRD-K14533399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.91426
hypothalamus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	1.07044
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UTHO-0011-R6A-SM-3GIJW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.998687
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.848725
SNU-182	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05833
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
PMC9795333-mmc4.xlsx-HUES66_Ex_CTIP2_C3-X-linked_genes_BCL11B	Rummagene Transcription Factor Associations 2026	1.0	null
ED-71-GA72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.440901
SLF1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00754786
GSE151612_4_v_2_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
XPNPEP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01523
GSE217405_0_v_2_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NOS1	DepMap CRISPR Gene Dependency	1.0	2.65511
Rectum adenocarcinoma_READ_TCGA-DY-A1DG-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1Q0-01A-21R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAFA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6132
BRD-K81418486_vorinostat_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A26711594_NICARDIPINE HYDROCHLORIDE_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_LNCaP clone FGC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.2215
AE-52-NW93_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208605
GTEX-TSE9-3126-SM-4DXSY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12307
496100336_TCx_no dementia_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.06968
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06531
BTBD19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0075704
Interrenal cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.657
Cerebral gyrus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.17
GSE174701_1_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
distribution	GeneRIF Biological Term Annotations	1.0	null
Diarrhea	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.371
SMAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.2163
External iliac artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.619
extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
2526_EIF1AD_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.54468
2129_DDX54_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.48145
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100651_FWM_probable Alzheimer's disease_TBI_83_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.20525
GSE210101,GSE210114_4_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOS	CCLE Cell Line Gene CNV Profiles	1.0	2.09598
COASY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00293021
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
pancreas	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.434523
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
limitans nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.06304
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
IL10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00792027
VZ in rostral cingulate neocortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.954591
CRIM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00877248
SARS-CoV MA15_Day4-PFU-10^4_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.30217
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234334,GSE234336_1_v_0_zhx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
311 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
PARPBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00692642
Accessory olfactory bulb	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07655
GTEX-PWN1-0226-SM-2S1OZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Petal	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.286
6135_PCNA_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.75441
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18781
PMC7439444-aba1972_Table_S9.xlsx-NR1D1_motif-Nearest_Ensembl_NR1D1	Rummagene Transcription Factor Associations 2026	1.0	null
Breast - Mammary Tissue	GTEx Tissue Gene Expression Profiles 2023	1.0	4.91375
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10401
hormone metabolic process	GO Biological Process Annotations 2015	1.0	null
BRD-K16207499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06989
SOX2-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1924
Serotonin receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.941
CTCF_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892513
BRD-K25791914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17694
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.42401
BRD-A60513937	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24803
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	142.108
Ventral premammillary nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.13728
FUT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0048272
SOX2-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
CD28	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540947
H3K4me1_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CCR6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00631595
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
3134_FOLR3_P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.75216
2125_DDX49_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.81664
primary auditory cortex (core)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.830822
Pulp	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.572
PMC7412812-13059_2020_2115_MOESM11_ESM.xlsx-All_H3K27me3-Upregulated_in_SERBP1_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.30239
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K14109347_LY2603618_HA1E_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
713_AURKAIP1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.67356
BRD-K75806288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67423
BRD-K41895714_AS-605240_HS578T_3_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MCF7_Decitabine_1µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0119795
BRD-A92357389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04094
GSE217363_4_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
abnormal postnatal growth/weight/body size	MPO Gene-Phenotype Associations	1.0	null
H3K27me3_H7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K20000640_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TOP2B_drug inhibition_GSE1417_341_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
spinal cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.469211
BRD-K91600270_NCGC00242557-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HDQ-P1	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93416
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.874342
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.707
Arcuate hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.70151
golgi apparatus part	GO Cellular Component Annotations 2015	1.0	null
GSE146982_4_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
1898_CSNK1A1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.17392
COL16A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03967
GTEX-PWCY-2226-SM-2S1OP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825336
Small Cell Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
Pancreatic cystadenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
mecamylamine-7023	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.21919
FU97	CCLE Cell Line Gene CNV Profiles	1.0	1.52749
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6937-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K85441584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89687
shell of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.69088
SLC44A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652484
GTEX-TMMY-1526-SM-4DXST	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00491
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-K63436213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04949
ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.172912
BRD-K50247051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62504
PMC9061835-41523_2022_425_MOESM1_ESM.xlsx-S3_Differential_GEX-Table-S3_Differential_expression_analysis_results_for_SOX10-high_versus_SOX10-low_TNBCs_from_the_TGCA_and_METABRIC_expression_datasets_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
Fetal Heart	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.918162
BRD-K97764662_PD-173074_HME1_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5C1-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tuber	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.853
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.01906
ATF2_S_UP.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	1.0	null
5735_NOL6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.77496
AF-00-QK19_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.21306
TFAP2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	132.665
SC5b-7 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.85
SLC19A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635359
6581_POT1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13157
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.844161
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.09219
BRD-K61354976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95181
Brain Lower Grade Glioma_LGG_TCGA-FG-A70Y-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34691
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCIH1651	CCLE Cell Line Gene CNV Profiles	1.0	2.36415
ZWINT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480805
GTEX-XOTO-0011-R8A-SM-4B65J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84282
intermediate stratum of THyB-P	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.66471
BRD-K28545166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07475
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
1409_CDC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18411
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EF-92-OO68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.349634
Acute Myeloid Leukemia_LAML_TCGA-AB-2857-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Paraventricular nucleus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.258
CRCGN009_HEPG2_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.63524
hydroxyzine-2024	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intermediate stratum of THyB-I	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	2.12636
abnormal motor capabilities/coordination/movement	MPO Gene-Phenotype Associations	1.0	null
HNF4G_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NL3H-0011-R5a-SM-2I3GB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87041
GSE253089_0_v_1_ephb2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE229973_4_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neural lobe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.656
ADH5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00256317
GTEX-XBED-0008-SM-47JWO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
SKMM2	DepMap CRISPR Gene Dependency	1.0	4.04624
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71243741	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60171
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.226
CRCGN013_HEPG2_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.724
Lung adenocarcinoma_LUAD_TCGA-64-5774-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMYD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00546767
globus pallidus, external segment, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.878097
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VRK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00465581
GTEX-XOTO-0011-R3A-SM-4B64W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.66191
PRELID3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69741
cortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.13663
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PAQR7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00855986
Fibrillation	DisGeNET Gene-Disease Associations	1.0	null
MCAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0061106
INS-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.613
basal ganglia disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.46466
CLNK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00534872
GSE144231_4_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_4602_KO_Mst_SRP246200	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.74444
Retrosplenial area, ventral part, layer 6b	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.09454
Pituitary	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.96376
GTEX-RUSQ-2026-SM-4GIAK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-K28296557_Akt inhibitor IV_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE229973_4_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
UA-39-TN76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.409284
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.18774
Tuberomammillary nucleus, ventral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52252
C6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00479066
Perturb_2467_KO_NAT10_SRP388804	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.55141
intracellular	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.286245
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.03318
E2A_KO_GSE43224_679_mouse_DN2 cells from WT and E2A-deficient murine fetal thymi	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
LRP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00567382
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K45859834	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02655
GSE139427_2_v_1_ibrutinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1897	CCLE Cell Line Gene Expression Profiles	1.0	1.35352
BRD-K96254487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55145
MA-67-FQ44_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.334896
GSE234289_5_v_2_rfx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K78344913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70835
6577_POP7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.18746
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF837	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54429
GTEX-NL4W-0011-R5a-SM-2I3GD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876288
GTEX-S7SF-0226-SM-3K2BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A75409952_wortmannin_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
7142_RBBP6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.04527
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.860343
BRD-K72173400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43304
SLVL	DepMap CRISPR Gene Dependency	1.0	4.92441
GTEX-QMR6-0011-R10A-SM-32PKO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852229
Caryopsis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.942
Prostate adenocarcinoma_PRAD_TCGA-EJ-7312-01B-21R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NSF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00429368
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
tamoxifen_homo sapiens_gpl3921_gse33366	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CREB3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3589
Basal ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.569
epitiostanol-2922	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K16943897	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16729
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.347
GSE216273,GSE216292_14_v_8_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K74305673_IMD 0354_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Main olfactory bulb, granule layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.22233
ART3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00599832
BRD-K08940439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34694
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.607
differ	GeneRIF Biological Term Annotations	1.0	null
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
19185848-TableS1	GeneSigDB Published Gene Signatures	1.0	null
Hepatomegaly	CTD Gene-Disease Associations	1.0	1.22979
GSE148692,GSE148695_7_v_3_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fibrils	GeneRIF Biological Term Annotations	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AQ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fetal Growth Retardation	CTD Gene-Disease Associations	1.0	1.11809
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3387-11A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
digestive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.07386
SREBF1	ENCODE Transcription Factor Targets	1.0	null
KC-32-GO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.210086
Microcytic anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.045
LY75	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00577438
BRD-K27881972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63672
CTSG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554332
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pyramus (VIII), molecular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.82226
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
levetiracetam_rattus norvegicus_gpl1355_hippocampus_gds1864	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Breast ductal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
1489_CENPP_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.58406
3872_HNRNPL_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03127
SLC13A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00680696
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.602552
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100436_FWM_no dementia_no TBI_95-99_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.8366
MAFF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0137328
GSE80446_2_v_1_anakinra_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CE-24-LQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.218997
Perturb_10394_KD_ARID1A_SRP200727	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K27ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Leaf sheath	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.681
5707_NMD3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.90208
7523_RPS3A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.04989
GTEX-Q2AG-0226-SM-2S1P4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-K02130563_S1030_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE148252_1_v_4_npas4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
LC-12-VN85_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.342015
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC7532671-thnov10p10957s2.xlsx-Table_S6A-Table_S6A_Differentially_expressed_genes_DEGs_in_DDX5_KD_versus_WT_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
extracellular organelle	GO Cellular Component Annotations 2015	1.0	null
GSE179880_9_v_5_e2f4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
RAI2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551515
2102_DDX10_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.09843
BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_PL21_6.0_h_0.63_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Ventromedial hypothalamic nucleus, ventrolateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.68552
pancreatic beta cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.504318
Nucleus lentiformis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.017
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.237042
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K24743998	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.22473
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998956
HOXA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00614474
NCIH2106	CCLE Cell Line Gene Expression Profiles	1.0	1.81967
COVID-19	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.895
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968113
Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IL-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K92241597_CHR 2797_HT29_24.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K34209560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65545
LN443	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33277
GSE161800_0_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
isoflurane_rattus norvegicus_gpl341_fear_gds2037	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XPVG-0526-SM-4B65N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.905301
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K52094743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03698
iopamidol-7189	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CP in caudal hippocampus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.923939
tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.6214
GTEX-WFG8-0926-SM-3GIKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Stria terminalis	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.858
Prelimbic area, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.07263
GTEX-X88G-0326-SM-47JZ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01424
nervous system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.871061
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.868739
Corpus striatum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.169
4150_INTS5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.25517
Stipe	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.362
BRD-K76617730	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40656
GTEX-RU72-3126-SM-46MUB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82768
GSE217363_0_v_1_nlrp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216273,GSE216292_14_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
PMC8519939-41525_2021_248_MOESM5_ESM.xlsx-LEF1_UP_V1_UP-Gene_name_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
OCT4-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BB-86-BE19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.303911
Hmx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.4839
MINDY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00512542
cerebellar cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.03328
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.948876
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268495
Leaf lamina	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.26
CUX1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OOBK-0226-SM-2YUMF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
adrenal medulla	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.440274
QF-41-QW99_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.205303
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.58713
BRD-K56837922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32881
Medial preoptic nucleus, lateral part	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.24554
BRD-K22503835_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
mBAF complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.662
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3214
paraterete nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.6802
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	5.0594
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCC44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.78618
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26442
Plant bud	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.933
7463_RPL35_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.37444
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LC-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TB-06-VB30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.289439
BRD-A19500257_geldanamycin_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	249.075
6856_PSMB7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.17879
excretory gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K12077693	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49333
BRD-K42308740_ST056792_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE90019,GSE90020_5_v_2_phf8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
JUND	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00933335
GTEX-UTHO-1026-SM-3GAF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957223
GGT7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00628085
CGAS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00768773
neuroendocrine cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.898595
GTEX-PWOO-2426-SM-2S1OV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
9911_XRN2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03631
SEMA3D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00689606
Perturb_8612_KO_miR1792_SRP076942	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.71715
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.882
PMC11067031-pnas.2317690121.sd05.xlsx-Sheet1-Differentially_expressed_genes_between_PML_RARA_GFP_vs_Empty_vector_GFP_human_hematopoietic_cells_at_day_7_by_single_cell_RNA-seq_RARA	Rummagene Transcription Factor Associations 2026	1.0	null
6560_POLR3F_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11998
BRD-K02526760_QS 11_HT29_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Diencephalon	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.889
BRD-K06486611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27765
GSE193258,GSE193259_5_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZR-75-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34692
BRD-K16472144_-666_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BRD-K95927760	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11452
CHD1	ENCODE Transcription Factor Targets	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.59318
EZH2_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cisplatin_homo sapiens_gpl570_gds3910	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WHSE-0011-R2A-SM-3P5ZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06796
RCOR1	ENCODE Transcription Factor Targets	1.0	null
Perturb_15753_KO_Ezh2_SRP096837	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
EF-74-KW12_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206957
BRD-K34808207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70057
Iron deficiency anemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.124
AIRE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627751
GSE202587_1_v_0_xrn1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_Droxinostat_10µM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0165593
pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
IP6K2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00510117
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913935
NCIH747	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66767
BRD-K84710243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.70131
ventral posteromedial nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.50133
GSE238018_1_v_2_mxra8_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68007270_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TPBGL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588443
Enteroendocrine cell_Small intestine_Mouse	CellMarker Gene-Cell Type Associations	1.0	null
GSE218727_0_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Edema	CTD Gene-Disease Associations	1.0	1.16035
20003503-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
7566_RRP7A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.43187
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5639_KD_SOX2_SRP174102	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
MS4A13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574995
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
BB-11-JI42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.271632
IB-94-WM88_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258516
GTEX-N7MT-0011-R7a-SM-2I3FZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1987
PMC10246722-pwac062_suppl_supplementary_table_s5.xlsx-sg-HIF1A_vs_sg-GAL4-Differentially_Expressed_Genes_DEGs_of_OE-HIF1A_vs_OE-GAL4_Veh_in_Bulk_RNA-seq_Data_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07101857_NCGC00183216-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BON-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.71
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.93001
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RS-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	1.0	1.67882
GSE130081,GSE130082_5_v_1_neil2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VA-06-DB75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.202203
BRD-K56001384_A8674_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Mood disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.793
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.73
BRD-K52154207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05298
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.402422
BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE261563_5_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XOTO-0008-SM-4GICE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13861
GSE151612_4_v_7_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A65B-01A-12R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LILRA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0102224
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12155
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.099
GTEX-TKQ2-1026-SM-33HB7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07867
DNAJB9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00695702
BRD-K64474460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58976
pick body	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	1.08323
G57321FI	GlyGen Glycosylated Proteins	1.0	null
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5191-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.992376
EZH2_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DPF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.68674
PHYHIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14206
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K73574487	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53002
PMC11754605-41467_2025_56327_MOESM3_ESM.xlsx-R157K_vs_MSX1-Gene_name_MSX1	Rummagene Transcription Factor Associations 2026	1.0	null
cerebellum	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.754537
Blood serum	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.993
GSE157383_3_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_1387_KO_IPO13_SRP128496	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.38431
Perturb_14942_OE_hPRDM15_SRP182668	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.46631
GTEX-S7SE-0011-R2A-SM-2XCDC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875911
Prostate adenocarcinoma_PRAD_TCGA-KK-A7AY-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN011_HEPG2_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.295
ZNF266	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20741
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12469
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47723
7501_RPS13_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.75293
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
1192_CARF_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11646
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SKMEL5	BioGPS Cell Line Gene Expression Profiles	1.0	1.1716
BRD-K12867552_THM-I-94_HA1E_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.8
hsa-miR-3151	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
SETDB1_02_52	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.51551
BE-71-AV63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.229276
Dehydration	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K68853384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14161
Lingula (I), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-2.65381
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.849477
Perturb_15084_KD_SLC4A11_SRP238854	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
TA-34-CK62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203334
MAPK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09426
EPHA1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00652789
terminal paraventricular area of THyA	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03508
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2731_ESF1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.46771
abnormal duodenum morphology	IMPC Knockout Mouse Phenotypes	1.0	null
posterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.59848
GABRA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00824912
kidney_d	HPA Tissue Sample Gene Expression Profiles	1.0	1.47676
BRD-K19269952	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37929
GSE113952,GSE113953_1_v_0_chtop_human	RummaGEO Gene Perturbation Signatures	1.0	null
Breast carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.294
GTEX-WL46-0011-R5A-SM-3LK6V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57467
BRD-K01614657_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
peduncular part of dorsomedial hypothalamic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.03221
GSE92457_9_v_12_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.83092
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Q-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242290_3_v_11_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HEY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.65467
GPR84	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00674257
GTEX-WZTO-0011-R7B-SM-4E3IS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20208
BRD-K34581968_BMS-536924_HA1E_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
IMPDH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00432413
GSE139987_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
REST_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5673_NIP7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13425
CTCF_LNCaP clone FGC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0011-R6B-SM-4E3J6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35559
orbital frontal cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.905932
GSE142684_4_v_7_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SFTPD	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00720364
TMEM9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620734
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15442833	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01001
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Avian pallium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.569
SLCO1C1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00489861
GTEX-QEL4-0326-SM-3GAE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
trapped	GeneRIF Biological Term Annotations	1.0	null
GSE147056_2_v_1_actl6b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K98676510_N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-pyridin-2-ylthiophene-2-sulfonamide_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Neuropathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.095
CRCGN015_MCF10A.TP53.M_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3892
POLR1H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22536
GTEX-NPJ7-0011-R5a-SM-33HBK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864821
PMC7617064-EMS151900-supplement-Extended_Data_Figure_5_Source_Data.xlsx-HSLC_D9_DEG-Logfold_change_threshold_1_0_CENPX	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.6618
Muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.197
BRD-K17140735_-666_CL34_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCL23	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00787233
62_ABT1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.11853
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875377
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
FF-06-MO73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.38692
GSE210951_1_v_0_islr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
negative regulation of peptidase activity	GO Biological Process Annotations 2015	1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.39271
RAD21_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.62928
CLIC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00661905
membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.24124
regulation of catalytic activity	GO Biological Process Annotations 2015	1.0	null
GTEX-PSDG-1126-SM-2S1ON	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895393
GSE119978,GSE180930_0_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-35-DU85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.519175
mafenide-1441	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1599	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7927
ventrolateral prefrontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.915852
Orbital area, medial part, layer 5	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.44105
Haustorium	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.763
Brain Lower Grade Glioma_LGG_TCGA-S9-A6U5-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE228106_0_v_2_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217663
Endocrine pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.673
Methyl accepting chemotaxis protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.955
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.239
GTEX-Q2AG-0011-R7A-SM-2HMJP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10654
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.14706
CTCF_MCF-7_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JHH2	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
GTEX-XLM4-3126-SM-4AT6M	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02227
7492_RPP38_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.36659
mRNA_GATA3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
UPMD1	DepMap CRISPR Gene Dependency	1.0	2.00186
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
CDC42	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00534419
CTCF_MCF-7_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A74K-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5244_MRPS14_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.05163
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864714
Leaf tip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.656
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K34387287_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC5384880__F5	PFOCR Pathway Figure Associations 2024	1.0	null
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ovary	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.947702
PMC5798892-41421_2017_3_MOESM7_ESM.xlsx-TM_KO_vs_WT-Supplementary_Table_S2-2_Up-_and_downregulated_genes_in_ATF6_cells_relative_to_ATF6_cells_in_the_presence_of_TM_early_passage_ATF6	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ASPH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00454393
BNIPL	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00645284
NUB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.7888
496100346_FWM_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.74701
BRD-K35671498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57116
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.927153
GSE101336_1_v_3_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.878
GTEX-NL3H-0011-R4a-SM-2I3GK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.886782
ACTL6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12168
POLR2A	ENCODE Transcription Factor Targets	1.0	null
GSE190384,GSE190386_6_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.922821
GSE130401_4_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IL9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00476317
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.619524
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9482_UBA52_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1325
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.587
YEATS4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36007
GSE154936_3_v_2_remdesivir_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
iPS-20b Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.28773
BRD-K81931105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14525
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MCF7_IOX2_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015085
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.573
9400_TTK_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.38949
GTEX-S4Q7-1626-SM-3K2AE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843655
GTEX-WHSE-3126-SM-3P5ZI	GTEx Tissue Sample Gene Expression Profiles	1.0	2.36578
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.752
Perturb_15070_KD_Twist1_SRP150075	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-11.8352
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.71754
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K19766710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28449
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.989056
CIBAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98386
LDHC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490778
BRD-K43543979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37872
GSE146962_0_v_1_glucosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
suboptic nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.52252
GSE146982_0_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NOC3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01611
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.327
640_ATP11B_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.03488
GSE201877_1_v_0_yap1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC5384880__F5	PFOCR Pathway Figure Associations 2023	1.0	null
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.6588
BRD-K07482874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.77021
9938_YKT6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10511
BRD-K76908866_CP-724714_MCF7_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE139016_0_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
TRIM22	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93205
cisplatin_mus musculus_gpl339_gse6206	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.695763
NANOG	ChEA Transcription Factor Targets	1.0	null
decreased vertical activity	MPO Gene-Phenotype Associations	1.0	null
Primary bacterial infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.345
CACNG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00796293
Cerebrospinal fluid	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ventral part of THyB	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.89013
CEACAM4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00875769
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6ME-01A-22R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146982_3_v_2_gpd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.050728
REST_Panc1_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Nipple	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.678
GTEX-X261-3226-SM-3NMC3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88865
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
CLIC3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00628688
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21306
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL120	DepMap CRISPR Gene Dependency	1.0	2.23092
HK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00490436
BRD-K64860451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15102
Perturb_4677_KO_Dppa2/Dppa4_SRP218369	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.41347
CLEC2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00633148
POU5F1-18347094-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
TF-04-RX73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.557777
BRD-K37634338	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3133
peptide hormone processing	GO Biological Process Annotations 2015	1.0	null
KE39	CCLE Cell Line Gene CNV Profiles	-1.0	-1.6102
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE142210_9_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0011-R4A-SM-3MJFS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1182
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S341-1826-SM-3K2AB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
BRD-A19500257_geldanamycin_MDAMB231_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of hormone levels	GO Biological Process Annotations 2015	1.0	null
FCRL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608529
IFIT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00731917
PMC4082364-supp_ddu111_ddu111supp_table12.xls-wtWT1_down-Table_S12_MSC_wtWT1_-_top_100_genes_down-regulated_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.915173
BRD-K85493820_KM 00927_ASC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
RANBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82302
18812457-Table3	GeneSigDB Published Gene Signatures	1.0	null
PCDH17	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00680372
GSE76425_0_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-32-EI69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.436499
MXI1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Sarcoma_SARC_TCGA-IS-A3KA-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rhabdomyolysis	CTD Gene-Disease Associations	1.0	1.04201
dorsomedial part of VMH	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.50901
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28326
Perturb_4577_OE_Haspin_SRP271373	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.40187
MDAMB134VI	CCLE Cell Line Gene Expression Profiles	1.0	1.36488
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	1.91341
GTEX-X585-0011-R6A-SM-46MVJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.972
PPP1R16B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621344
Plant hair	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.659
BRD-K88429204_Pyrimethamine_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CF-97-AV07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.2095
NCI-H650	COSMIC Cell Line Gene CNV Profiles	-1.0	-2.93416
GTEX-T6MN-0011-R6A-SM-32QP8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06691
GSE196671_5_v_1_obox4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T5JC-0011-R2A-SM-32PLZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.87652
mRNA_NRIP1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
core part of the anterobasal nucleus	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.38541
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.6502
MORN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.010097
PMC12211354-12915_2025_2224_MOESM6_ESM.xlsx-Sheet1-Sheet1_The_source_list_of_zebrafish_Npas4b_targets_from_human_NPAS4_targets_in_CHEA3_database_NPAS4	Rummagene Transcription Factor Associations 2026	1.0	null
TT	GDSC Cell Line Gene Expression Profiles	1.0	1.82696
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.02068
Lung adenocarcinoma_LUAD_TCGA-NJ-A55R-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K83341545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00454
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1706
Lung adenocarcinoma_LUAD_TCGA-97-A4M0-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LHX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.86251
BRD-K50140147_NVP-TAE684_MDAMB231_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.08762
NCIH1963	CCLE Cell Line Gene Expression Profiles	1.0	1.42255
BRD-K54637865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37824
MEIS3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9033
GTEX-R55F-0011-R8A-SM-2TF4F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02462
BRD-K68202742_trichostatin A_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.74569
HLA-DRB1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00587464
BRD-A60245366_AS-601245_MDAMB231_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.1968
mediodorsal nucleus of thalamus_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44632
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
A549_Barasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0114369
2113_DDX24_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00474
GTEX-S7SE-0011-R7A-SM-2XCDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46658
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.532961
GSE111660_1_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KRAP_Deficiency_GDS3528_564_mouse_Liver	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
ATP5MGL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.33349
TT	CCLE Cell Line Gene CNV Profiles	-1.0	-1.68008
BRD-K87726525_NCGC00182382-01_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K30488928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54438
Agnosia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.123
GSE210580_0_v_1_rag2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE138863_2_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5700-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NL4W-0011-R6a-SM-2I3GA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950957
Synucleinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.375
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
21205295-TableS1	GeneSigDB Published Gene Signatures	1.0	null
WRAP53	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00544696
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.238
GYPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00910938
Fibromyalgia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.023
INA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.374
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.52813
Corticotropic cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.573
GTEX-X4XX-0011-R10B-SM-46MWO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963822
BRD-K44298652	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09723
EOMES-20176728-TROPHOBLAST STEM CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.3823
head	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.764468
CESS	GDSC Cell Line Gene Expression Profiles	-1.0	-1.44108
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.172
Lung adenocarcinoma_LUAD_TCGA-55-8091-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_3 yrs_F_12836	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0944
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
W-13-440	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
6512_POLA1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.32468
Folium-tuber vermis (VII), granular layer	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	-1.0	-1.31886
PLD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581796
UF-06-JB00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211233
H3K27me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11778
5885_NUP107_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.31529
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5841
BRD-K81418486_vorinostat_SW948_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-OIZH-1826-SM-2YUNP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01003
CTCF_MEL cell line_mm9_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36243
VZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.34001
JE-55-OJ53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.203939
SUCLG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0053699
HK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00543881
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3445-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.03452
receptor binding	GO Molecular Function Annotations 2015	1.0	null
Paraventricular hypothalamic nucleus, parvicellular division	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	1.0	1.0211
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0977
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053064
CTCF_02_185	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.61973
KANSL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00685
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33033
GTEX-S7SE-0011-R5A-SM-2XCDA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08103
CYP21A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00485403
GLIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.2868
PRICKLE4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04952
VZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06239
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.598684
HCC70	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40362
BRD-K12502280_TG101348_A549_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
LD-69-ZV56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.6338
Perturb_17540_OE_DAXX_SRP351980	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.48839
MB-32-LQ97_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.362599
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RASA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32006
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.435275
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
G29931IJ	GlyGen Glycosylated Proteins	1.0	null
CHP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00459222
SHISA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00631199
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00148
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.61209
S0-EE-YC7H_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.374103
BRD-K90311252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85641
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61958
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.98591