association	dataset	threshold value	standardized value
GSE193541_1_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-05-4426-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE164874_5_v_12_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
TEAD-YAP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.622
TRAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84295
gluconeogenesis	GO Biological Process Annotations 2025	1.0	null
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
fundamental	GeneRIF Biological Term Annotations	1.0	null
PMC6428271-pone.0213813.s007.xlsx-LPS_anti-IL-10_significant_GOs-ensembl_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN009_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.22219
internal male genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.535438
ZNF143	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.9465
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73B-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_11_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7286-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN009_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98258
Brain Lower Grade Glioma_LGG_TCGA-DU-A6S6-01A-21R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21361
ENTPD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46569
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
AKIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7062
BA-69-TQ80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376743
Liver	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880643
Idarubicin (hydrochloride)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0104095
CRCGN014_HEPG2_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.80953
3686_HELLS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.557207
GSE221577_3_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pentoxifylline_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0239899
SNU-61	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC10531073__F3	PFOCR Pathway Figure Associations 2024	1.0	null
GSE111247_11_v_9_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.033
SAAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29836
BA-68-FJ41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.382035
CRCGN010_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.99856
CEM-ADR5000 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.59
PC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.527
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Eukaryotic translation elongation factor 1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.77
HCC1143	CCLE Cell Line Gene CNV Profiles	1.0	2.4096
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228371
TRAPPC13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45967
Photosystem II oxygen evolving complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.559
thalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.356347
FF-90-JK74_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260044
CRCGN012_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8072
CRCGN015_MCF10A.TP53.M_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.94693
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81743
GSE169590_6_v_5_rptor_human	RummaGEO Gene Perturbation Signatures	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
GSE221577_4_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XXEK-0326-SM-4BRVV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848954
GSE217541,GSE217543_0_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.195
GTEX-XYKS-0926-SM-4BRVG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04148
EPI-2298-1 (BRAF)	NURSA Protein Complexes	1.0	null
Bone disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
GSE134375_6_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Peripheral nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.154
SRSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4571
RBPJ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73445
GTEX-OXRP-2326-SM-2S1NL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48383
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and neck carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.202
CE-24-LQ98_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.315826
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8651
IGF2BP1	Pathway Commons Protein-Protein Interactions	1.0	null
PCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55G-0126-SM-48FDS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21626
Lung squamous cell carcinoma_LUSC_TCGA-94-7557-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4733-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE107956,GSE107957_0_v_1_ythdf2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PAPOLG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07098
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of cilium movement	GO Biological Process Annotations 2023	1.0	null
motile cilium	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CRCGN011_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5365
CRCGN014_HEPG2_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.23135
GSE202434,GSE202438_9_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
xlinked	GeneRIF Biological Term Annotations	1.0	null
SNU-1040	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.56449
GSE211425_1_v_0_mettl3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JPT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58441
GSE149901_2_v_1_anlotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CALCOCO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4555
MCF12A	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.995979
EFR3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53318
ED-33-YZ72_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.288927
ciliary part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
CRCGN016_MCF10A.TP53.M_24H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.14615
hexose biosynthetic process	GO Biological Process Annotations 2025	1.0	null
Afatinib_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0165712
ZBED4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	163.321
CRCGN010_HEPG2_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.0883
EEF1B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47438
gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05495
MYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0994
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.65959
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	1.0	2.02074
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77243
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYO18A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34277
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Digestive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
positive regulation of cilium-dependent cell motility	GO Biological Process Annotations 2023	1.0	null
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.946993
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.2208
SK-HEP-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.84
CRCGN017_MCF10A.TP53.M_24H:B18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54412
GTEX-UJMC-1826-SM-3GADT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59691
skeletal muscle	HPA Tissue Gene Expression Profiles	-1.0	-0.975289
GSE199092_1_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Epirubicin (hydrochloride)_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0130387
ZNF524	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.8005
CRCGN013_HEPG2_24H:K04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.23501
Pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.998
GSE157894_2_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Muscle tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
Bladder carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
GTEX-QCQG-1726-SM-3GIJ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06608
CRCGN017_MCF10A.WT.HP_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.3708
GSE201110_0_v_1_sirt4_human	RummaGEO Gene Perturbation Signatures	1.0	null
ELOA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.96876
RERFLCSQ1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.71826
PMC11214527-mmc5.xlsx-POU5F1-gene_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE209582_1_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
OTX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6025
CRCGN011_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7351
FKBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55283
3632_HARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.535689
male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	1.14093
FA-47-IB34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253421
corl105	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.83
GSE157036,GSE166411_3_v_1_halofuginone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RFLNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8933
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
adrenal gland	GTEx Tissue Gene Expression Profiles	1.0	1.09282
Mitochondrial fatty acid beta-oxidation multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.884
sperm part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
P-19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.654
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1075
AB-84-PK04_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208539
CRCGN012_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.84129
Glucagon signaling pathway	KEGG Pathways 2026	1.0	null
hsa-miR-1207-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE120612_7_v_2_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DAOY	DepMap CRISPR Gene Dependency	1.0	3.15449
CRCGN008_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.70415
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Up_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
REXO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63354
EE-03-SG02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280413
GSE227592_4_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
PRAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4892
Lung squamous cell carcinoma_LUSC_TCGA-60-2696-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
QA-98-TQ46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.396227
GSE180185_9_v_10_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE186440,GSE186443_3_v_7_daxx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FD-29-MM50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.472922
Sarcoma_SARC_TCGA-MO-A47P-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR6A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9063
ALDOA	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LMBRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87378
GTEX-PW2O-1726-SM-2S1OO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43456
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.41288
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.7833
PMC6935105-40170_2019_206_MOESM9_ESM.xlsx-HIF1_up_VENN-697_elements_included_exclusively_in_HIF1_genes_HIF1A	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF282	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.543
CRCGN014_HEPG2_3H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12863
hsa-miR-151-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GTEX-U3ZN-1626-SM-4DXTZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.969255
HE-80-BQ08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214741
PANC 02.03	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19823
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13675
OB-20-LP90_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.71815
Erythromycin_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0298474
ZNF302	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4329
9+2 motile cilium	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
MZ in posteror frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0192
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.458918
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.15914
GSE105169,GSE105175_0_v_1_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OXRN-0011-R10A-SM-2I5GC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.867207
Chondroclast	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.671
4star	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.08195
Epirubicin (hydrochloride)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0167546
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.46596
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3319-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNRNPH1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE211128_3_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-DX-A7EF-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE201668_0_v_1_ncor2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-P4QT-1626-SM-2S1NP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65107
CRCGN009_HEPG2_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.66239
GTEX-SSA3-0326-SM-32QPS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05196
SLU7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10788
testis	HPA Tissue Protein Expression Profiles	1.0	0.928216
SMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30763
GSE85880,GSE85881_4_v_2_tretinoin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160442,GSE160444_1_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4959-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.7719
CRCGN016_MCF10A.TP53.M_24H:B17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01046
GTEX-WL46-0011-R3A-SM-3TW8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20663
EA-18-FP00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.77852
CRCGN014_HEPG2_3H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33777
GSE135350_3_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75498
plant vessel	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
7929_SIRT7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.502008
5216_MRPL34_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.504472
CRCGN017_MCF10A.TP53.M_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7981
Musculoskeletal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
Fatty acid beta-oxidation multienzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.881
GTEX-U3ZH-1626-SM-3DB74	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829223
DYNLT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45842
NCIH3255	CCLE Cell Line Gene CNV Profiles	-1.0	-2.09926
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE140997_4_v_8_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
cingulate gyrus, retrosplenial part, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.845148
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
internal segment of globus pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.993134
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7032
GSE205729,GSE205731_2_v_3_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.57
Sympathetic ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.154
GTEX-QDVN-2426-SM-2S1Q4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825361
ESO51	DepMap CRISPR Gene Dependency	1.0	4.20584
PGAP6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34542
GSE155162,GSE155169_1_v_3_buparlisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6212
5447_NADSYN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.581513
GTEX-Q2AH-1826-SM-2S1Q2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.898308
Heart primordium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.714
CRCGN014_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-10.0
CRCGN009_HEPG2_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.66946
RVH421SKINFV1	DepMap CRISPR Gene Dependency	1.0	3.90637
CRCGN015_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8257
JAK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61152
Hippocampal cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.829
Prostate adenocarcinoma_PRAD_TCGA-HC-7737-11A-02R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5788-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE160817_3_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Naproxen_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0583061
CRCGN013_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-10.0
CRCGN013_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3115
Pancreas	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.08461
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE231891_5_v_0_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.87545
YJEFN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32478
hsa-miR-3691-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Lung adenocarcinoma_LUAD_TCGA-78-7146-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
biological_process	GO Biological Process Annotations 2015	1.0	null
GRHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2345
CA-10-RU23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227083
Caco-2/TC7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.894
CRCGN015_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.25953
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nicotinamide nucleotide metabolic process	GO Biological Process Annotations 2025	1.0	null
GTEX-UTHO-2726-SM-4JBH9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4048
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04798
CRCGN012_HEPG2_24H:J20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.56421
CRCGN015_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16828
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of cilium-dependent cell motility	GO Biological Process Annotations 2025	1.0	null
Futibatinib_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00818823
GTEX-WZTO-0011-R3B-SM-3NMC6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11324
ASCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43215
CB-62-TB77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262167
Naproxen_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0331166
BCL11A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7042
Lung squamous cell carcinoma_LUSC_TCGA-43-6771-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00931
temporal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.753
CRCGN016_MCF10A.WT.HP_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.74584
GSE171572_5_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U4B1-1426-SM-4DXTX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843005
GSE249544,GSE249637_6_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WYJK-1726-SM-3NM9U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.71572
GTEX-XBED-0226-SM-47JY8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853286
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6705
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.040296
Connective tissue disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.351
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.543599
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.3598
DMXL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13918
Head and neck cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.314
membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.058021
CRCGN015_HEPG2_48H:E18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62212
GTEX-R55E-0008-SM-48FCG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.980144
Proteasome storage granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.507
CRCGN008_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.06555
fat_e	HPA Tissue Sample Gene Expression Profiles	1.0	1.33471
Pancreatic islet	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.549
Corpus striatum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.856
organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
lymphoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.8017
CRCGN015_MCF10A_48H:K14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.78204
CRCGN009_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.75841
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
Erythromycin_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0421411
Pentoxifylline_HepG2/C3A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00507941
SNX17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54674
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.0
CE-18-AP15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223851
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE211128_9_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GE-53-SM76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21437
Epirubicin (hydrochloride)_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0180163
2542_EIF2S2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.01138
Astrocyte cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.544
TBX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7521
ZB-16-BR73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.329985
primary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.190582
GTEX-OHPK-1626-SM-2YUN3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15689
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25787
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8206
SLC49A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20887
HCC2185	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.53444
DA-10-ZX00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.250947
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11425
Respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.479
TMEM14B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.77881
CRCGN015_MCF10A.WT.HP_24H:H20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.42561
TE-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.523
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
pyruvate metabolic process	GO Biological Process Annotations 2025	1.0	null
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-UPIC-1026-SM-4IHLT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22108
Cingulate cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.907
ZNF93	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	122.336
PMC6977700-aging-12-102667-s004..xlsx-Stage1-The_identified_3126_dysregulated_LmiRM-CTs_in_stage_1_of_MI_1_day_of_MI_using_our_method_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
NAALADL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47151
hypothalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F1-01A-11R-A034-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NB-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.089
FB-49-NW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.234551
ZNF460	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	159.143
SPRED2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90627
centromedian nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.17483
Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A7D7-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE173307,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7846
Lung squamous cell carcinoma_LUSC_TCGA-98-A538-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SERTAD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64899
GTEX-XPT6-2026-SM-4B64V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09317
DD-75-HY40_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.548973
NELFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.18391
GLRX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87308
GB-73-QS80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.346309
ZNF597	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00691
GTEX-O5YV-0008-SM-4E3HP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14546
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AB-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OIZI-0726-SM-2XCEI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880217
GTEX-VJWN-0426-SM-3GIJI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58699
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07517
Head and Neck squamous cell carcinoma_HNSC_TCGA-HL-7533-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-548ak	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
5468_NARS_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.02753
MRRF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04924
GSE158834_1_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.33105
TMEM167A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56988
GSE185744,GSE185747_2_v_3_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.84924
TRIM28	ChEA Transcription Factor Targets	1.0	null
GSE205913_1_v_0_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sperm plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.593
glucose metabolic process	GO Biological Process Annotations 2025	1.0	null
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.834464
C22orf23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73006
TBC1D7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80365
GSE140997_4_v_5_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of cellular component movement	GO Biological Process Annotations 2015	1.0	null
ZNF653	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31701
GTEX-T6MO-0326-SM-32QOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.999364
Lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.316
FNBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55131
F5 meningioma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.768
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.41919
GTEX-TMZS-0326-SM-3DB9P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956868
generation of precursor metabolites and energy	GO Biological Process Annotations 2015	1.0	null
PLC-PRF-5 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.636
SET2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913037
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47152
GTEX-RU1J-0326-SM-46MUM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15907
Lung squamous cell carcinoma_LUSC_TCGA-46-6025-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_10_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193351_1_v_2_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SLC8A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5781
duodenum	HPA Tissue Protein Expression Profiles	-1.0	-1.15587
CRCGN013_HEPG2_24H:I14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.19437
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.69134
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.58502
hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
TBX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.1625
1-alkyl-2-acetylglycerophosphocholine esterase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.559
GSE209582_1_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
z85	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
GTEX-O5YT-0008-SM-4E3IQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53246
JAGN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69426
CRCGN014_HEPG2_3H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.35947
XRCC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98288
MGMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00767
HCC-78	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.56449
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.973349
GATA1::TAL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6759
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3891
PLEKHA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28474
GSE147626_2_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-P4QT-0008-SM-48TDZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2609
CRCGN008_HEPG2_24H:O16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.02415
AB-82-ES53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.258516
CRCGN017_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4117
Cervicovaginal fluid	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.743
Bisoprolol (hemifumarate)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0118758
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.50565
NEURL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87683
Prostate adenocarcinoma_PRAD_TCGA-EJ-7783-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ICC10	DepMap CRISPR Gene Dependency	1.0	3.35619
GSE157296,GSE157298_4_v_1_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.07875
Epirubicin (hydrochloride)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0114338
Organ system benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.101
20174566-TableS1	GeneSigDB Published Gene Signatures	1.0	null
8886_THG1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.767275
OCIMY7	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5424
Rectum adenocarcinoma_READ_TCGA-AF-2691-11A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HNRNPL	Pathway Commons Protein-Protein Interactions	1.0	null
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.5644
GSE205976,GSE205978_2_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pentoxifylline_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0134405
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.928526
TFCP2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86946
DNAJC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41909
GSE120612_7_v_0_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LD-69-ZV56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314005
vitamin c_homo sapiens_gpl6884_gse16590	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.078553
phosphoglycerate mutase activity	GO Molecular Function Annotations 2025	1.0	null
GSE115364_0_v_1_idh3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE211128_9_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20952
DHX9	Pathway Commons Protein-Protein Interactions	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN010_HEPG2_24H:A08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0663
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34729
GSE154577_6_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
RNASEH2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11713
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:N07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83206
GSE214725_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-76-JB92_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329189
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0526-SM-3DB75	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16093
263_ALG11_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.03751
Naproxen_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0421224
CRCGN010_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.17214
hsa-miR-548b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
TF-04-RX73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.588801
GTEX-RVPU-0008-SM-3NM8B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.987034
FA-65-UA27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.244461
PGK1	Pathway Commons Protein-Protein Interactions	1.0	null
AC-31-PL89_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214707
micropexophagy-specific membrane apparatus	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.702
GSE154577_6_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63263
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.264199
Pons	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.791
extracellular vesicle	GO Cellular Component Annotations 2015	1.0	null
VCB complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.874
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9557
GSE201309_1_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.26403
LIPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85294
CRCGN017_MCF10A.WT.HP_24H:F15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.77145
IRF2BP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.4221
CRCGN011_HEPG2_24H:O24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.88795
GTEX-N7MS-0426-SM-2YUN6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35508
Male Infertility	DisGeNET Gene-Phenotype Associations	1.0	null
DA-07-LL18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.659972
NT5C2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09917
BD-04-NG34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.370458
CRCGN016_MCF10A.TP53.M_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.99118
JD-00-TT75_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214298
U2OS	CCLE Cell Line Gene CNV Profiles	1.0	1.9593
GTEX-WHSE-0126-SM-3NMBT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853178
RERFLCAD2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.86424
PFN1	Pathway Commons Protein-Protein Interactions	1.0	null
cell part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041282
GTEX-S32W-0926-SM-4AD5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07132
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Erythromycin_COLO 205	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0186744
GSE240896,GSE240899_3_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	1.0	2.92607
CRCGN012_HEPG2_24H:G07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.78382
GTEX-N7MT-0726-SM-3TW8S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05298
GSE219195_1_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	1.0	null
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
ZDHHC23	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32207
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09713
GTEX-WHPG-2226-SM-3NMBO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.24005
NE-94-VE83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338257
KLF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09207
CRCGN015_MCF10A_48H:F24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.28835
GTEX-VUSG-1426-SM-3GIJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59482
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Neurodegenerative disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.389
GSE261563_9_v_8_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pentoxifylline_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0144274
CRCGN017_MCF10A.TP53.M_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8986
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15989
TMEM43	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.28682
GSE202434,GSE202438_2_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
2277_DNAJA3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.500064
PMC6428271-pone.0213813.s007.xlsx-LPS_anti-IL-10_significant_GOs-name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RNOR-0011-R9A-SM-2TF52	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928724
CRCGN014_HEPG2_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.5363
bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN013_HEPG2_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.57181
Ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.151
b-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Naproxen_HepG2/C3A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0197818
CRCGN012_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.78992
GTEX-R55E-0011-R7A-SM-2TC5Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.848787
GSE209973_1_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
3654_HBS1L_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.504141
vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.092477
KYSE-140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930942
CRCGN015_MCF10A.WT.HP_24H:C09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29786
HNRNPR	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A_48H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8679
GSE178907_4_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Erythroleukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BARX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39229
COLGALT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.8327
NB1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PMC6977700-aging-12-102667-s006..xlsx-Sheet1-The_identified_1173_dysregulated_LmiRM-CTs_in_MI_using_our_method_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
plant form	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
EC-41-PH99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259268
GTEX-OIZG-1326-SM-2HMIQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01666
GSE111247_14_v_4_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SJXC-0526-SM-2XCFG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.87955
MS751	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.01339
Lung squamous cell carcinoma_LUSC_TCGA-52-7811-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.063935
CF-50-QK79_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231891
GTEX-OXRO-0126-SM-2YUN4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01836
NKX2-8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79801
GTEX-U3ZN-2226-SM-3DB88	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32441
CRCGN015_MCF10A_48H:J06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.14882
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Unnamed_13_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26305
Endoplasmic reticulum palmitoyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.062
GTEX-T2IS-2626-SM-32QPP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48784
QE-00-EB96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280665
6851_PSMB3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.556256
HCC1806	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.608826
Mouth disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
AGRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95411
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.19633
CRCGN011_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-10.0
GSE220097_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75121
PPIA	Pathway Commons Protein-Protein Interactions	1.0	null
7057_RAC3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.13654
GTEX-T2YK-0008-SM-4DM6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.123
GSE246660_1_v_0_lmo3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.49454
CRCGN017_MCF10A.TP53.M_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0331
COX6A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85818
cell projection part	GO Cellular Component Annotations 2015	1.0	null
CRCGN009_HEPG2_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12891
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.92983
Dendritic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.799
CRCGN009_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83775
NPIPB13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81265
SULT1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11071
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4076-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPIB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33099
Oral squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.203
GTEX-OXRO-0011-R9A-SM-3NB1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876199
cytoplasmic part	LOCATE Predicted Protein Localization Annotations	1.0	null
FRAT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64051
TBX20	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0587
TMEM69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57438
WD-62-UB45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257926
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.245
GTEX-P4PQ-0008-SM-48TDX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00599
BMI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51158
PPAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45924
CB-49-OG36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.85384
WASHC2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2585
NCIH747	CCLE Cell Line Gene CNV Profiles	1.0	1.78428
GTEX-UTHO-2426-SM-4JBHD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09726
NR4A1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2173
CRCGN015_MCF10A.TP53.M_24H:C15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.88405
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7071-01A-12R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Obesity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
Glycogen storage disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.243
Eyestalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
ZNF483	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16355
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.872314
821_BET1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.01487
CRCGN015_HEPG2_48H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.91776
TMEM145	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85671
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
phosphorus metabolic process	GO Biological Process Annotations 2015	1.0	null
Epirubicin (hydrochloride)_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0197657
Crus I, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01985
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SP9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	138.972
CRCGN009_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.01609
MOLT-4 cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.893
GTEX-RTLS-0526-SM-2TF64	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16211
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EJ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UACC257	DepMap CRISPR Gene Dependency	1.0	6.13268
GSE159473_0_v_1_eif5a2_human	RummaGEO Gene Perturbation Signatures	1.0	null
DHX57	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.67382
telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
ASPC1	DepMap CRISPR Gene Dependency	1.0	2.00206
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3HY-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9996
BD-61-OO16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.546036
CRCGN017_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45561
VPS39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98919
AGS	DepMap CRISPR Gene Dependency	1.0	3.74442
BE-69-RD44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208732
RXRA::VDR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3
GLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04828
OGFR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80339
Sarcoma_SARC_TCGA-DX-A23U-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.086
DA-81-VY50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.410698
CRCGN009_HEPG2_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22068
Erythromycin_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0243849
CNOT6L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40383
CRCGN016_MCF10A.TP53.M_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.14711
Naproxen_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0343873
CTCF_GM20000_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
wm115	HPA Cell Line Gene Expression Profiles	-1.0	-1.0696
CRCGN013_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14914
CRCGN017_MCF10A.WT.HP_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50985
CRCGN012_HEPG2_24H:P07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.60939
Epirubicin (hydrochloride)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0256513
H4C16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93741
Rectum adenocarcinoma_READ_TCGA-DY-A1DD-01A-21R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SNAI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6102
CRCGN008_HEPG2_24H:A06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3266
GSE190384,GSE190386_0_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
PCYT1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17615
gallbladder_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.40855
sperm part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.111736
GSE142210_4_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.93655
VIPAS39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30656
glycolysis and gluconeogenesis	KEGG Pathways	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BI-01B-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.872887
GSE206226_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4726-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50374
GTEX-SUCS-0008-SM-4DM53	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36163
CRCGN011_HEPG2_24H:P04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1207
Erythromycin_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0331788
PMC6428271-pone.0213813.s007.xlsx-LPS_significant_GOs-name_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-X8HC-0526-SM-4E3JA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20402
FC-13-VS25_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.560598
Interstitial cell of Cajal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LRATD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.82559
SNU1196	DepMap CRISPR Gene Dependency	1.0	3.4936
GTEX-U4B1-0826-SM-4DXTW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849846
NFATC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42591
7929_SIRT7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.17949
Adrenocortical carcinoma_ACC_TCGA-OR-A5K9-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HC-74-HM63_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.416933
EEF2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WK11-2526-SM-3NM9Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977124
Lung squamous cell carcinoma_LUSC_TCGA-43-7657-01A-31R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A7U9-06A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN012_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.13875
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.55396
GSE211128_7_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.91725
SLX4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96502
KLHL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86324
PMC9341507-supp_gr.266924.120_Supplemental_Table_S4.xlsx-A_Jurkat_essential-MYB_MYB	Rummagene Transcription Factor Associations 2026	1.0	null
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.0868
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51567
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7873
Cytoplasmic vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.765
GSE193993_5_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.625
AE-85-LR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.893621
GSE200839,GSE233826_2_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
SERF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5669
Atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.153
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.209
sense organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Methionine adenosyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.767
KBTBD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67722
EIF5AL1	Pathway Commons Protein-Protein Interactions	1.0	null
COLO-783	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856438
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE225869_1_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALDH9A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57535
extracellular vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.057922
Lung squamous cell carcinoma_LUSC_TCGA-60-2723-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
AC-97-KP88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.524775
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.920091
Erythromycin_C32	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0101126
SCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93853
sclc21h	HPA Cell Line Gene Expression Profiles	-1.0	-2.38192
GTEX-R55E-0011-R4A-SM-2TC5H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09402
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6497
CRCGN017_MCF10A.TP53.M_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1383
Prostate adenocarcinoma_PRAD_TCGA-J9-A8CL-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
epithalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
RIMS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36719
GSE135350_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE195568_3_v_4_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.82935
GSE205976,GSE205978_3_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Colon cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.475
GTEX-WWYW-0526-SM-3NB2W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.6176
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:P07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.60757
CALO cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.502
seed	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN017_MCF10A.TP53.M_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.32696
FLI1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42195
ARF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83908
FAM174C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46042
Lung adenocarcinoma_LUAD_TCGA-55-7724-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RU72-1326-SM-2TF6T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12375
PIK3CA	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN010_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.84745
TRIM28-17542650-NTERA2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3233
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:A04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.83304
MESD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75089
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.671224
GSE133087_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Erythromycin_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0240773
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03565
GTEX-UTHO-1026-SM-3GAF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859276
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A5Y0-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.96995
Thoracic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.901
GSE229671,GSE229673_0_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AA-62-JP26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241404
6250_PGAM1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-1.06661
CRCGN015_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.64281
POM121	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20954
Bone sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.024
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.1254
Thyroid gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.34
HCC1359	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.911434
GTEX-NL3H-0011-R10A-SM-2I3E9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28493
AD-00-WA10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.33502
CRCGN016_MCF10A.TP53.M_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.24875
LBHD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06122
GTEX-S95S-1426-SM-2XCDM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.59691
Epirubicin (hydrochloride)_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0146148
CRCGN008_HEPG2_24H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.77975
CRCGN008_HEPG2_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6168
BA-84-TD72_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.97207
PPM1H	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10205
GTEX-XGQ4-0226-SM-4GIDS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.830533
AA-23-FM46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.586165
ZNF189	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19874
GSE128730_4_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE125403_7_v_0_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
eye	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
YWHAE	Pathway Commons Protein-Protein Interactions	1.0	null
paraventricular nuclei, right of thalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.904998
DA-66-OE69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.748581
HIVEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93835
DF-57-BL63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.241112
ALDH6A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68025
GSE125014_6_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Naproxen_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.038769
NKX2-4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.1959
hsa-miR-362-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.415386
vesicle	GO Cellular Component Annotations 2015	1.0	null
CB-99-OG76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259454
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-W5WG-1126-SM-4LMK4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97273
PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RIPOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08263
hsa-miR-4300	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
PMC12956708-DataSheet1.xlsx-Supplementary_Table_7-Supplementary_Table_6_The_DEGs_from_high_altitude_between_AMS_and_non-eAMS_group_of_GSE75665_TWIST2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE158834_2_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
organelle part	GO Cellular Component Annotations 2015	1.0	null
Mammary gland tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.273
GTEX-V1D1-1926-SM-4JBGX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924753
FLNB	Pathway Commons Protein-Protein Interactions	1.0	null
KA-29-AB08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.223087
CRCGN017_MCF10A.TP53.M_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50367
GTEX-UJMC-0008-SM-4IHKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.458
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EDNRB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1381
7541_RPTOR_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.23318
EVSAT	CCLE Cell Line Gene CNV Profiles	1.0	1.4744
SPTLC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70369
Quinidine (15% dihydroquinidine)_BT-474	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00369812
HAND2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.3242
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8068
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MZ in caudal cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.866232
GTEX-U8XE-1726-SM-4E3IF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878601
Kidney renal papillary cell carcinoma_KIRP_TCGA-IZ-8195-01A-31R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gfi1b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.4231
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12314
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3335-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZFPM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51232
hsa-miR-548ab	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
CRCGN008_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.8552
CRCGN012_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.8416
GSE237053_1_v_0_comt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sperm flagellum	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.50765
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.90924
ZNF674	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80907
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.33858
CRCGN014_HEPG2_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73676
LCOR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76563
ZIC4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.5941
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.790008
CRCGN014_HEPG2_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.00739
IGFBP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82788
nonobstructive	GeneRIF Biological Term Annotations	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4331-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.608487
PMC7288929-aging-12-103203-s002..xlsx-upregulated_by_BCL6-TargetID_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
Liver carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.782
GSE159678_4_v_3_chloroquine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.6059
among	GeneRIF Biological Term Annotations	1.0	null
ZNF414	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12029
Adrenal cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.609
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
KC-48-OO62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19304
8594_SUPT16H_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.09704
TMEM198	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.99468
CRCGN014_HEPG2_24H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.24352
1197_CARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.554067
YWHAB	Pathway Commons Protein-Protein Interactions	1.0	null
Epirubicin (hydrochloride)_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0121243
GTEX-X5EB-0526-SM-46MVP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88776
CRCGN015_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.18048
CRCGN017_MCF10A.TP53.M_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.08562
SW579	CCLE Cell Line Gene CNV Profiles	1.0	1.64888
CRCGN010_HEPG2_24H:I16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36741
carbohydrate metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	1.0	2.1987
GSE132369,GSE132371_5_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ALPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41163
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IT-01A-31R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193900,GSE193905_1_v_0_pura_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.984964
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.437023
CRCGN015_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.77439
CRCGN017_MCF10A.WT.HP_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65745
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5680-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FTC-133	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.940454
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36861
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
CRCGN013_HEPG2_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.80824
PPP1R15A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.33463
frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
RD-90-DS77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.230485
CRCGN011_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.5355
ZNF214	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00474
MANBAL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.17159
stomach	HPA Tissue Protein Expression Profiles	1.0	0.928216
Integumentary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
GTEX-TML8-0526-SM-32QOQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.03572
GSE242083,GSE242098_2_v_0_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S7PM-0526-SM-3NM92	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49301
Colonic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.472
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.21428
CNOT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06211
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1841
SNRPB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13258
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21927
CRCGN016_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.64258
LOU-NH91	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.06418
FANCG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58305
seedling	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.18535
organic substance catabolic process	GO Biological Process Annotations 2015	1.0	null
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.97917
GB-01-UN23_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.301383
CH157MN	CCLE Cell Line Gene CNV Profiles	1.0	1.35481
GTEX-XPT6-0008-SM-4B64Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.918139
NCI-H460 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.775
Skin Cutaneous Melanoma_SKCM_TCGA-IH-A3EA-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GLI4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63514
GSE225869_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
DHX36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56982
Clobetasol propionate_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00831651
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52327
GAPDH	Pathway Commons Protein-Protein Interactions	1.0	null
C-33-A	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-P4PP-0008-SM-48TDV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40882
GTEX-Q2AG-0011-R1A-SM-2HMJI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09908
SW1271	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.56449
GSE160442,GSE160444_4_v_0_arid1a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.41788
PBX1-22567123-OVCAR3-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE193402_0_v_3_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE155800_1_v_0_imatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.43537
CRCGN011_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.995
HSP90AA1	Pathway Commons Protein-Protein Interactions	1.0	null
SPIB	JASPAR Predicted Transcription Factor Targets	1.0	null
S0-EE-Y7IR_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.952199
PMC6977700-aging-12-102667-s006..xlsx-Sheet1-The_identified_941_dysregulated_LmiRM-CTs_in_MI_using_traditional_method_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16047
GSE200897_1_v_0_pold1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Erythromycin_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.031797
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DA-20-VR86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211846
gonad	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.71501
Right atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.136
THAP12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.6352
Left atrium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.153
GTEX-X5EB-0004-SM-46MWA	GTEx Tissue Sample Gene Expression Profiles	1.0	2.11476
SEMA3G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54402
DF-84-RT50_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263805
FA-12-QB17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232313
Acute Myeloid Leukemia_LAML_TCGA-AB-2969-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GA-81-DL34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.392138
GAREM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7601
Brain Lower Grade Glioma_LGG_TCGA-VW-A7QS-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83106
GSE102505_4_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128730_7_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1187	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15819
thyroid gland	HPA Tissue Protein Expression Profiles	1.0	0.928216
SW780	CCLE Cell Line Gene CNV Profiles	-1.0	-1.98759
GE-29-ZM45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.533001
APAF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.57162
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.523815
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49352
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07175
GTEX-RWS6-2126-SM-2XCAV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62642
CRCGN014_HEPG2_3H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63094
CHPF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76109
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6616
thyroid_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.23544
GTEX-X5EB-2026-SM-4E3KA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876756
CRCGN011_HEPG2_24H:M02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.36615
SPAG8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38639
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1288
GSE158834_10_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16667
MZ in frontal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0922
Naproxen_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0361236
CRCGN016_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05073
CRCGN015_HEPG2_48H:B11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5893
GTEX-PSDG-0426-SM-2S1OF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25697
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.333441
Subrhabdomeral cisterna	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.53
GTEX-X585-0011-R8A-SM-46MUX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10468
BA-95-YU85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.480381
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE201309_4_v_2_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Erythromycin_HOP62	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.02293
MAF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.835
GTEX-NL4W-0008-SM-4E3I2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43827
XD-44-FJ34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.368806
GBGT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12307
CRCGN009_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.56315
Lung adenocarcinoma_LUAD_TCGA-44-2668-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
leukocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
ACSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.58383
TACSTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77875
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.89929
AA-98-PM63_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277497
CRCGN016_MCF10A.TP53.M_24H:E04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.27531
TMEM102	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96744
GTEX-R45C-0926-SM-3GAD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855919
HIF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.35
GSE127261_1_v_2_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
20087356-TableS5	GeneSigDB Published Gene Signatures	1.0	null
TIPARP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45461
GSE211128_3_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
SDHAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76864
lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
Peripheral nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.066
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05259
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.897
CRCGN015_MCF10A.TP53.M_24H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87105
MSANTD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17405
Erythromycin_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0306036
Uterus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
XA-12-UL84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.354105
SMG9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60408
9656_USP39_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.609441
PAX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6246
blast cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.572872
GSE160817_2_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.824
Respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.896
CRCGN016_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.64356
Erythromycin_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0355306
FUT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71531
lymphoid tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
Pancreatic ductal adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.424
CRCGN008_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.3251
phosphate-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
Hepatocellular carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.785
GTEX-QEG5-0226-SM-2I5GI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24257
GSE186471_1_v_0_carnosol_human	RummaGEO Drug Perturbation Signatures	1.0	null
pyridine nucleotide catabolic process	GO Biological Process Annotations 2025	1.0	null
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951043
GSE185519_4_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular organelle part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.5914
PIP4K2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.555
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97913
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74761
TRPM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84564
GSE57871_8_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	0.928216
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VRK1	Kinase Library Serine Threonine Kinome Atlas	1.0	null
plumule	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
NCIH1838	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41869
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MGA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.8776
ATP13A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06659
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.54032
DYNLL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56638
GSE166920_6_v_5_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
QE-79-XO29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25518
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-T2IS-0008-SM-4DM75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01209
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.94523
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14681
Lonafarnib_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00491406
azoospermia	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.924626
TRIM37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13154
HCC1011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.97995
extracellular vesicular exosome	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
choroid plexus of the lateral ventricle	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.43425
Spindle pole centrosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.552
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1416
4871_MAX_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.553069
hsa-miR-589	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
KLK13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60687
PMC12956708-DataSheet1.xlsx-Supplementary_Table_6-Supplementary_Table_5_The_DEGs_from_sea_level_between_AMS_and_non-eAMS_group_of_GSE75665_TWIST2	Rummagene Transcription Factor Associations 2026	1.0	null
TULP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00643
KCTD15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33987
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900041
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.738615
DCAF17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51062
Mesothelioma_MESO_TCGA-MQ-A4LM-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Allantoin_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.019145
vorinostat_homo sapiens_gpl10558_gse35242	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.051286
GTEX-Q2AG-0011-R3A-SM-2HMJ9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16229
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4853-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.845355
vascular tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
MATR3	Pathway Commons Protein-Protein Interactions	1.0	null
ZB-16-BR73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.325512
HSFX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21444
CRCGN014_HEPG2_3H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.47475
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skeletal muscle cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.511
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73843
GTEX-Q2AI-0226-SM-48U1D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10723
Nutrition disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
AR-21915096-LNCAP-1F5-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.70157
GSE154577_2_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
SUM229PE	DepMap CRISPR Gene Dependency	1.0	3.82209
CRCGN017_MCF10A.WT.HP_24H:O12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.76235
Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.24599
9909_XRCC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.21137
GSE180789_1_v_0_hnrnpc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
carboxylic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.71191
ZNF76	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	48.9969
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0958
GTEX-R55E-0011-R5A-SM-2TC5N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.964389
Ophthalmic nerve	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.077
GSE147366_3_v_2_med13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE134375_0_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TM9SF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34906
CRCGN015_MCF10A.TP53.M_24H:I23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.66275
TRAPPC6B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.08408
GSE183335,GSE183351_1_v_0_lin28b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pentoxifylline_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0173329
Pancreatic adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.477
KIF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05257
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.721
sperm flagellum	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
FOXE1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	72.6194
FTSJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06946
CRCGN014_HEPG2_3H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.75409
TLX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76489
CRCGN012_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.07925
EB-66-IH06_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.259757
NBEAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7913
GTEX-Q2AH-0126-SM-48U2B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.940723
BOP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.84631
PAX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1181
OV56	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.827223
DAD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53379
MPP89	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66423
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05069
CLK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.1645
DF-75-OU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.337186
AE-42-HT01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.262563
hsa-miR-25	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CD-05-PU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228051
ZNF20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7403
CRCGN017_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.70621
VPS37B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40876
TIMM29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48042
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	54.6567
GSE142588_2_v_1_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
JL1	DepMap CRISPR Gene Dependency	1.0	2.91767
GTEX-UPIC-0726-SM-3GADW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23296
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CRCGN015_MCF10A_48H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.12106
7634_SAE1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.07512
Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2866-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE190316,GSE190324_0_v_11_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.562178
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7647-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0714
GSE183041_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AC-84-QG99_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.298125
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-62-HP31_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37107
Lymph	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
DOR 13	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.869402
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97772
Lung squamous cell carcinoma_LUSC_TCGA-66-2778-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PLZ6-1526-SM-2S1OC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59439
Idarubicin (hydrochloride)_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0126236
CRCGN011_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.0263
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
BE-31-XV38_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203568
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
Erythromycin_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0352491
FLYWCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67985
NUDUL1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47225
GTEX-Q2AG-0011-R10A-SM-2HMLA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32053
BD-11-DV28_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.977566
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ES-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RVPV-0008-SM-47JYW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53461
GSE68925_1_v_0_fasudil_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H3122	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.56449
Brain Lower Grade Glioma_LGG_TCGA-VW-A8FI-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
8271_SON_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.11091
TMEM141	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04239
SYNJ2BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35357
GTEX-WVLH-0011-R2A-SM-3MJFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904899
GSE213588_10_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_1_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
S0-EE-Y97N_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224767
SNAI3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.3635
Muscular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.181
Crus II, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00496
Afatinib_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0268034
Idarubicin (hydrochloride)_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0155635
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.12088
Breast carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
Water	HMDB Metabolites of Enzymes	1.0	null
FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8403
hsa-miR-4490	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
CRCGN014_HEPG2_3H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94754
GSE113817_0_v_1_bach1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.867084
hsa-miR-3618	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
HNRNPH2	Pathway Commons Protein-Protein Interactions	1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.910162
Afatinib_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0203456
GTEX-WZTO-0826-SM-3NM8Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29858
hsa-miR-1245b-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE182680,GSE182683_10_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
AA-39-BD24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267218
3980_HSPA9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.643773
NPIPB11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12422
GTEX-RU1J-1726-SM-2TF5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16642
BC-15-EL49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.474333
18450603-Table3S	GeneSigDB Published Gene Signatures	1.0	null
GSE182680,GSE182683_5_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02479
Central nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.695
GSE249544,GSE249637_9_v_2_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BC-11-LL59_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208084
METTL6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84647
ARNT::HIF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2212
CRCGN013_HEPG2_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.68196
PMC6335596-mmc2.xlsx-RNA-seq_Day_3_GATA6_Het-Genes_significantly_differentially_expressed_between_H9_and_GATA6_4ins_at_day_3_in_RNA-seq_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN015_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.42252
Lung adenocarcinoma_LUAD_TCGA-55-8205-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.83755
occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SQ1	CCLE Cell Line Gene CNV Profiles	1.0	1.63151
BFTC905	CCLE Cell Line Gene CNV Profiles	-1.0	-1.66055
GTEX-SUCS-1626-SM-32PLS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.8376
GSE197850_4_v_2_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
BICR10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
observed	GeneRIF Biological Term Annotations	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.873252
GSE161846,GSE161849_3_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
AA-62-HP31_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.401475
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.5164
NPM1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S341-0526-SM-4AD5U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865945
ALG6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46363
NCIH1930	CCLE Cell Line Gene CNV Profiles	-1.0	-2.59447
GTEX-RUSQ-0826-SM-47JWW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20554
facial motor nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.884191
CD68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95111
NANOGNB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45501
GSE247230_0_v_1_anp32b_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-DX-A1L4-01A-12R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ED-02-CL76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.496624
ZBTB21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40322
Cilium	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN014_HEPG2_24H:I01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39917
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826941
adrenal gland	HPA Tissue Gene Expression Profiles	1.0	0.865239
hsa-miR-939	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE195559_2_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SP-01B-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.55359
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7996-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02326
Cingulate gyrus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.907
TMED7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98354
GTEX-UTHO-0011-R1A-SM-3GIJO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946392
PITX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9678
region	GeneRIF Biological Term Annotations	1.0	null
GSE158834_11_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R55C-0008-SM-48FCF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11367
ficolin-1-rich granule lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
CRCGN015_HEPG2_48H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.83261
SCaBER cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.7
ESR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65575
GTEX-P4QR-0008-SM-48TE2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13389
Carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
THYN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.87374
MRPL40	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19884
SR 11237	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
GSE212760_0_v_1_fxr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_9_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
WC-09-GD62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.722226
PC-68-DU31_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.403982
YIPF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44068
skin	GTEx Tissue Gene Expression Profiles	1.0	0.869191
KLF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	96.311
Stigma papilla	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.6
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7905
GTEX-UPJH-0526-SM-4IHK8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43412
GTEX-RWSA-0826-SM-2XCBF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25946
cellular process	GO Biological Process Annotations 2015	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3IB-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Compton-North congenital myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.565
8661_TAF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02534
GTEX-U3ZN-2626-SM-3DB7T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08414
GSE148262,GSE150691_1_v_2_hdlbp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GC-73-YI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.421376
NCIH650	CCLE Cell Line Gene CNV Profiles	1.0	1.7919
GSE195514_0_v_1_stk25_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XPVG-0326-SM-4B653	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08127
Prostate adenocarcinoma_PRAD_TCGA-EJ-7125-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NFK9-0626-SM-2HMIV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46307
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.25055
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-87-SF89_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.700235
hsa-miR-4502	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
SCAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24783
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE93156_1_v_0_idelalisib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-64-KC49_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.562828
Erythromycin_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0162283
STRADB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24711
MDAMB175VII	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.85985
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
small molecule metabolic process	GO Biological Process Annotations 2015	1.0	null
NKX2-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12046
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5096-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN012_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.46205
Allantoin_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0249035
DA-58-LZ09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318067
Epirubicin (hydrochloride)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0218719
CORO1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75024
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Naproxen_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245365
protein-cysteine S-palmitoyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.062
6250_PGAM1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.25744
CRCGN014_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16714
NCIH1651	CCLE Cell Line Gene CNV Profiles	-1.0	-1.39552
Central element	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.598
Naproxen_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0568717
DNAJC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37844
GSE231891_5_v_4_cdk8_human	RummaGEO Gene Perturbation Signatures	1.0	null
ficolin-1-rich granule lumen	GO Cellular Component Annotations 2025	1.0	null
STK17A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86404
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.72
pyruvate metabolic process	GO Biological Process Annotations 2015	1.0	null
5900_NUP62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.52549
CNDP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02148
KRBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35361
lymphnode_5c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.848248
substantia nigra, compact part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.58099
Immune system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
Epirubicin (hydrochloride)_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0195711
JPH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21551
EC-98-KI28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.29778
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE193402_0_v_2_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE182180_1_v_2_secretin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE183113_1_v_0_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:E08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.072
Nanotubes, Carbon	CTD Gene-Chemical Interactions	1.0	null
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE197850_4_v_0_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
Erythromycin_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0271548
Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135350_2_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE116810_2_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.547
GSE213588_8_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.84739
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.2927
GSE165308_1_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	1.0	null
female reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.366381
CRCGN015_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.80115
UBE2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27914
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.732
CRCGN016_MCF10A.WT.HP_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62361
GSE211128_9_v_8_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
regulation of flagellated sperm motility	GO Biological Process Annotations 2023	1.0	null
Acquired metabolic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.271
Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-AF-5654-11A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-4499	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Neostriatum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.856
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6738
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-10.0
Bone marrow cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.98113
CRCGN014_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6621
GSE221577_2_v_0_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182680,GSE182683_7_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FD-62-ZB67_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207383
INA complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.82
TDRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86232
GTEX-R3RS-0726-SM-3GIJR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80137
ZC3H15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31022
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2R8-01A-21R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-53-7624-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HL-60/MX-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.577
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T5JC-0626-SM-3NMA6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.843429
GTEX-X88G-0326-SM-47JZ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857142
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	1.0	null
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.80198
Prostate adenocarcinoma_PRAD_TCGA-EJ-A8FO-11A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.6617
CRCGN016_MCF10A.TP53.M_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.44425
USP32	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69597
CRCGN017_MCF10A.WT.HP_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11504
Peripheral ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.326
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53385
GSE176008_8_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TSSC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21554
TD-17-NF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24429
CTCF_GM10266_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NR4A2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.352
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.44
LGMN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50079
sperm part	GO Cellular Component Annotations 2015	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-4749-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.26246
CRCGN014_HEPG2_3H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47477
cytoplasmic part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.04387
GTEX-TMMY-1126-SM-4DXSX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948744
paraventricular nucleus of the hypothalamus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.81527
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Breast cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF	ENCODE Transcription Factor Targets	1.0	null
Futibatinib_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0145667
FOXE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18843
GSE240439_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
13_AARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.628045
KA-63-FH23_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330992
PSMG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3253
GSE182680,GSE182683_7_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Epirubicin (hydrochloride)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0461099
PPP4R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80306
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.64482
CRCGN012_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.22099
SIAH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56138
B3GNT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00777
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE168604,GSE183859_1_v_0_selumetinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:D21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.07732
GTEX-WL46-0011-R10A-SM-3MJFQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19207
CFPAC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.603
ZFP57	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7448
CRCGN017_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3166
GSE230174_0_v_1_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PTMA	Pathway Commons Protein-Protein Interactions	1.0	null
AC-84-QG99_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.544098
BT20	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33814
CRCGN009_HEPG2_24H:L09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.55893
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04764
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4938
EIF5A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90811
Epirubicin (hydrochloride)_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0116002
Adrenocortical carcinoma_ACC_TCGA-PK-A5HB-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OHPN-0008-SM-4E3HW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10806
QF-71-QI30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206877
Acute Myeloid Leukemia_LAML_TCGA-AB-2932-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in posteroventral (inferior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.949114
GSE161825_1_v_0_tipranavir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_2_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.840383
ZR7530	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-2.75583
GSE205729,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nuclear cyclin-dependent protein kinase holoenzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.117
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.11211
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8ZZ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Skin disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.148
GSE202434,GSE202438_13_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YA-92-YO01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.243466
6-Mercaptopurine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.52
GSE128333_4_v_5_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
FGF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45021
ERLEC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63428
CRCGN017_MCF10A.WT.HP_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.60885
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16546
COLO 800	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.65959
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.167
CRCGN012_HEPG2_24H:D10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.39479
NKX6-2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76716
hsa-miR-4749-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GC-04-UF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.31012
3639_HAUS6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.504431
hsa-miR-4763-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
GA-88-CF36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.641117
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_0_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Pancreatic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.506
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6374
CA-42-YI34_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237246
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.1774
GMCL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81351
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9521
GTEX-P44H-0526-SM-2XCF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869445
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-73-TX58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.364143
Erythromycin_NCI-H460	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0334319
hsa-miR-329	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
ZNF331	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8604
CRCGN017_MCF10A.TP53.M_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.07204
CLDN12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.26915
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	1.0	2.06402
pineal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
adrenal_4d	HPA Tissue Sample Gene Expression Profiles	1.0	0.982629
SP5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.5324
meiotic	GeneRIF Biological Term Annotations	1.0	null
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PTRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19992
RPSA	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U412-0326-SM-3DB9L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.939071
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_4_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02156
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.013
CRCGN016_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.53268
medial geniculate complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.35279
DHX58	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5791
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178340_7_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DA-85-SU90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.507644
FANCI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.67412
biological regulation	GO Biological Process Annotations 2015	1.0	null
CRCGN016_MCF10A.TP53.M_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9711
H4K20me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WZTO-0011-R10B-SM-4E3KB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871331
GSE123943_1_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE185519_4_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QESD-1426-SM-2S1R9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19472
GTEX-OXRL-1626-SM-2YUMU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03282
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.05122
GSE182680,GSE182683_5_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Inner mitochondrial membrane protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.527
CRCGN008_HEPG2_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.559
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7X1-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TBX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.1448
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4859-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Afatinib_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0170044
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05326
GTEX-QLQ7-1726-SM-2S1QQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87306
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:E15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.7648
NOMO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35034
GTEX-QV31-1426-SM-2S1QD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.45822
WTAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.51871
GSE149621_3_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
outer SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33734
CRCGN012_HEPG2_24H:N08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33659
NYAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.54851
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.971193
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE220942_2_v_1_galnt7_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8574
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842369
Trigeminal nerve	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.077
Idarubicin (hydrochloride)_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0182479
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308559
Throat	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.341
3632_HARS_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.26526
HINFP	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.3977
Naproxen_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0232298
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7646-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331242
CRCGN011_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6133
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GTEX-U3ZM-1226-SM-3DB9G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02062
intracellular membrane-bounded organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.054977
GSE176008_0_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE181003_1_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.61431
MB-46-BT89_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.42381
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.959625
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI/ADR-RES cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.509
midbrain reticular formation, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.54625
TBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.1618
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.978156
CRCGN011_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.509
HNRNPK	Pathway Commons Protein-Protein Interactions	1.0	null
Phosphoglycerate/bisphosphoglycerate mutase, active site	InterPro Predicted Protein Domain Annotations	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0345
GTEX-VJWN-0726-SM-3GIJ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926893
lung	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
polymorphism	GeneRIF Biological Term Annotations	1.0	null
PKP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49678
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE225869_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prostate cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.517
MYH9	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XMK1-0226-SM-4B65D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12147
CRCGN014_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5233
TPI1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-OHPK-0008-SM-4E3JL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20777
PLBD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27447
4273_KARS_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.0947
BC-61-ZY95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.426856
CRCGN017_MCF10A.TP53.M_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35453
raphe magnus nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.829401
AW-10-0667_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228015
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.935
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GD-79-TW34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.06904
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.63
positive regulation of reproductive process	GO Biological Process Annotations 2023	1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.198
Erythromycin_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0262172
CRCGN017_MCF10A.WT.HP_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.2532
GTEX-R53T-1126-SM-48FD4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855578
AC-71-YF45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.294739
GTEX-QCQG-0008-SM-48U2G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93799
NIBR189	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
regulation of flagellated sperm motility	GO Biological Process Annotations 2025	1.0	null
REXO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01927
PPARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.6422
ZFP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.91196
KNOP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6446
GRHPR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64351
CRCGN010_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4783
TGFBR3L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.78021
GSE210373_0_v_1_cntnap4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TSE9-2626-SM-4DXV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868572
Mantle cell lymphoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.523
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942575
8557_STX5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.03454
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58689
CRCGN012_HEPG2_24H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.02753
PCBP2	Pathway Commons Protein-Protein Interactions	1.0	null
Clear cell renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.556
CRCGN017_MCF10A.WT.HP_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.2445
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5985-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Arid3b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.4235
GTEX-XOTO-0008-SM-4GICE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12148
reproduction	GeneRIF Biological Term Annotations	1.0	null
ZBTB11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1307
paracentral lobule, anterior part, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.846176
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72502
GTEX-QVJO-1426-SM-2S1QY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11527
BB-11-JI42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289134
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.556978
cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Central carbon metabolism in cancer	KEGG Pathways 2026	1.0	null
CRCGN009_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44472
positive regulation of cilium movement	GO Biological Process Annotations 2025	1.0	null
CRCGN017_MCF10A.WT.HP_24H:I11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.16185
HSF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1662
Isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.321
MZ in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.937414
WAOSEL	DepMap CRISPR Gene Dependency	1.0	2.74108
FA-36-VA24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.279844
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5869_NUDT21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.528254
Dendrite membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.779
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.988964
hsa-miR-1261	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Pentoxifylline_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0122838
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CAL-85-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09056
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7XN-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UTHO-1826-SM-3GAFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3084
ITM2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1914
mifepristone_homo sapiens_gpl6947_gse39654	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.94963
CRCGN016_MCF10A.TP53.M_24H:E21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53531
GSE102467_1_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.500024
DYNC1LI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17983
GSE130246_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
2269_DNA2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.528429
GSE202434,GSE202438_4_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:B12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.40884
CRCGN014_HEPG2_3H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.3298
Vesicle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-XXEK-0008-SM-4BRW7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00829
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19823
CRCGN016_MCF10A.WT.HP_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.38135
GSE240444_2_v_3_idasanutlin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210682_0_v_3_methadone_human	RummaGEO Drug Perturbation Signatures	1.0	null
DA-10-HD17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231159
CLIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00898
PPP1R13B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36815
Lung non-small cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.76
Pituitary gland cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.709
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
6792_PRPF19_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.518655
GSE215849_2_v_1_muc1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE180321_0_v_1_imperatorin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
brain_3c	HPA Tissue Sample Gene Expression Profiles	1.0	0.955305
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Dried cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.677
chromosome	GeneRIF Biological Term Annotations	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80K-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Alzheimer's disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
KA-75-LP02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.262885
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GAS2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91852
GTEX-TKQ2-0826-SM-33HB6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.89226
AE-56-SL06_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.247422
GTEX-TSE9-0626-SM-3DB8B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32869
GTEX-QDT8-0526-SM-3NMD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900221
GSE182680,GSE182683_7_v_12_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X585-0011-R10A-SM-46MUY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13616
GSE202434,GSE202438_2_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-483-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA41-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9365857-41598_2022_17887_MOESM1_ESM.docx-1-IKZF4_IKZF4	Rummagene Transcription Factor Associations 2026	1.0	null
GSE208171_0_v_1_zc4h2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158632_2_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.86987
PMC9794594-DataSheet_1.xlsx-ST12-Unnamed_6_KLF6	Rummagene Transcription Factor Associations 2026	1.0	null
positive regulation of cellular component movement	GO Biological Process Annotations 2015	1.0	null
Disease by infectious agent	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.334
AC-74-ZA35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.447652
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66813
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60303
GSE211128_3_v_6_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE129811_5_v_0_niacin_human	RummaGEO Drug Perturbation Signatures	1.0	null
glycolytic process	GO Biological Process Annotations 2025	1.0	null
PMC5578490-pgen.1006879.s017.xlsx-Top_ETV1_downregulated_genes-Gene_Symbol_ETV1	Rummagene Transcription Factor Associations 2026	1.0	null
DE-73-JX23_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.240831
GTEX-SIU8-0526-SM-2XCDP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06324
Erythromycin_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0238082
GSE160817_0_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE160817_5_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_2_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
extracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.38985
CRCGN012_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3121
GSE118816_2_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.787504
MZ in midcingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.08932
GTEX-U3ZM-1126-SM-4DXUB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85905
AF-83-BX08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212441
NBN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06686
Primary immunodeficiency disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
fallopiantube_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.95831
Mitochondrial tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.42
Respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.294
hsa-miR-4520a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
ZR-75-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.761
ventromedial hypothalamic nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.62138
han	GeneRIF Biological Term Annotations	1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.65973
LY6E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96431
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35721
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6609
Female reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.541
FD-79-TC61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303781
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LIMK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97895
Epirubicin (hydrochloride)_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0270396
WA-07 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.685
CRCGN014_HEPG2_24H:L05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.76922
Erythromycin_NCI-H1573	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.018112
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25486
GTEX-V1D1-0626-SM-4JBHN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00806
Cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GTEX-OIZG-0008-SM-4E3J2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35447
UPCISCC116	DepMap CRISPR Gene Dependency	1.0	2.38138
Amygdala	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.151
WFDC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.54207
SUM225CWN	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.33593
GSE131649_4_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PBX1	ChEA Transcription Factor Targets	1.0	null
XE-69-AT35_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.266539
FB-66-UU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366965
GSE95077_1_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.9684
RBMX	Pathway Commons Protein-Protein Interactions	1.0	null
GSE200839,GSE233826_3_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
azoospermia	GeneRIF Biological Term Annotations	1.0	null
Idarubicin (hydrochloride)_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.03196
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915581
Endometrial luminal epithelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.588
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9559
ESRRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0533
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7719
CRCGN008_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.0225
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.79866
CRCGN014_HEPG2_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.03315
hsa-miR-548a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
AE-88-WQ63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386468
inactivation	GeneRIF Biological Term Annotations	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-22-4607-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.62925
CALM1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63194
cerebellum	HPA Tissue Protein Expression Profiles	1.0	0.928216
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GB-73-QS80_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.293939
GTEX-N7MS-0008-SM-4E3JI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42785
CRCGN009_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69655
NCIH727	CCLE Cell Line Gene CNV Profiles	-1.0	-2.3514
GSE190384,GSE190386_3_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.WT.HP_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.99114
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.9682
MYCN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9527
CRCGN011_HEPG2_24H:B19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.10585
DSTN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.60181
CRCGN016_MCF10A.TP53.M_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.83311
HNRNPA2B1	Pathway Commons Protein-Protein Interactions	1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.475436
Vesicle lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.656
Naproxen_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0507872
Liver cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.853
CRCGN009_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.10272
GSE116930,GSE116935_1_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE200388_0_v_1_gemin5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ficolin-1-rich granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
VEGF-A complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.786
Prostate adenocarcinoma_PRAD_TCGA-FC-A4JI-01A-11R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XQ3S-0426-SM-4BOOA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64909
HC-74-HM63_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.248557
forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.08209
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BE-57-VZ17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.37074
ZNF667	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1755
Prostate adenocarcinoma_PRAD_TCGA-ZG-A8QW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE187006_3_v_2_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ovarian disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.391
GSE199204,GSE211619_4_v_7_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SRY	JASPAR Predicted Transcription Factor Targets	1.0	null
sirolimus_homo sapiens_gpl6244_gse15703	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-548h	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
2,3-Diphosphoglyceric acid	HMDB Metabolites of Enzymes	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7893-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WDR44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66119
GSE146982_4_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-548c-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GABPA_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3666
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BC-62-RZ55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.612171
Lung squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.545
GSE126463_0_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125403_7_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QEL4-0326-SM-3GAE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05024
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.712
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912025
CRCGN016_MCF10A.TP53.M_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32245
proton-transporting ATP synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.036
CRCGN015_MCF10A.TP53.M_24H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0491
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14895
6843_PSMA3_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.08059
Histidine phosphatase superfamily	InterPro Predicted Protein Domain Annotations	1.0	null
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.781409
Formate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.873
FBXL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06321
BA-28-XM73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214198
Epirubicin (hydrochloride)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0219116
TMEM245	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85766
parafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02582
peripheral portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.826876
GSE193402_0_v_4_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Hsf	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.555
GSE118816_2_v_1_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
T-lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.893
CRCGN016_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7248
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-MA-AA3Y-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:A15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.77492
GSE118816_0_v_3_myo1c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Afatinib_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0187666
GTPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.991
GSE149621_2_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EC-82-LV30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.800772
Integument	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
CRCGN015_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.40499
TMEM209	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1705
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.90204
LARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04288
FB-66-UU47_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.815391
chr10_97418381_G_A_b38	GTEx eQTL 2025	1.0	1.08055
CRCGN016_MCF10A.WT.HP_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6471
adult retina	HPM Cell Type and Tissue Protein Expression Profiles	1.0	1.10431
FIGLA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.63014
LC-12-VN85_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332805
PAQR6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41274
CRCGN012_HEPG2_24H:G06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.13221
NACA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78296
PMC8350904__EV4	PFOCR Pathway Figure Associations 2024	1.0	null
RPMI7951	CCLE Cell Line Gene CNV Profiles	1.0	1.42167
FC-20-EQ58_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.872099
NKX2-8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0444
EFM-192B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.47246
RFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.05043
UNC119	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.05018
Erythromycin_HT-29	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0168997
GTEX-S3XE-0926-SM-4AD4S	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00435
GTEX-Q2AH-0826-SM-48TZN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836062
organelle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.052213
CRCGN017_MCF10A.WT.HP_24H:G11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.43975
Sympathetic chain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.154
CRCGN016_MCF10A.TP53.M_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4923
AC-76-BB72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213263
GNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.50999
NMB	DepMap CRISPR Gene Dependency	1.0	2.72463
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
YME1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10654
8816_TELO2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.587155
Medroxyprogesterone acetate_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0110763
CRCGN009_HEPG2_24H:H03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.3841
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.849289
NKX1-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24709
I-II	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.990241
GSE149035_2_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MC-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:B19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59748
ZBTB33_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
gametocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.095971
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.065
GSE225869_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-VUSG-0926-SM-3GIK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839137
GSE147876,GSE147877_4_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3541_GRPEL1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.02023
Heart ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.004
HNRNPA2B1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47804
whole plant	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN014_HEPG2_3H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07668
SLC43A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9237
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
organic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
ABCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61281
DBF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52203
Erythromycin_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0137426
Lung squamous cell carcinoma_LUSC_TCGA-85-7710-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.23394
Spinal ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.326
GSE168401_2_v_0_harmine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ELF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0142
susceptibility	GeneRIF Biological Term Annotations	1.0	null
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.995668
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CRCGN014_HEPG2_24H:A15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09497
Uniplex complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.514
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.04648
GSE201309_4_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R55D-0008-SM-48FEV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.871026
GTEX-T5JW-1326-SM-4DM5G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920239
Lung adenocarcinoma_LUAD_TCGA-44-7661-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
IZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26937
CRCGN016_MCF10A.TP53.M_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59463
SA-32-CC58_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.46454
GTEX-REY6-0826-SM-2TF4S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.974906
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
WRN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37712
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73F-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184892_4_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	1.0	null
FE-64-KC49_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27478
CRCGN016_MCF10A.TP53.M_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.23021
CRCGN010_HEPG2_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.62672
GSE199538,GSE199539_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_11_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SBC5	CCLE Cell Line Gene CNV Profiles	-1.0	-1.59608
Uterine corpus cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
GSE95077_1_v_4_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-23-UM36_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.552933
GSE200839,GSE233826_3_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RVPU-0011-R5A-SM-2XCAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.825975
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6872-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.09026
6275_PHB2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.625837
CRCGN017_MCF10A.WT.HP_24H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.93186
HNRNPA3	Pathway Commons Protein-Protein Interactions	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-RY-A843-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE151612_0_v_8_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cerebral gyrus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.907
PKM2 protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.21
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.878255
CNN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77791
HE-80-BQ08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.987731
chaperonin-containing T-complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.941
13_AARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.534698
ATM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67878
Mitochondrial isocitrate dehydrogenase complex (NAD+)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.321
CLEC2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81824
Pentoxifylline_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226867
ASMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44095
GSE111247_14_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.49127
CRCGN014_HEPG2_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.26122
GATA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.4597
Cervix disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.26
CELF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35214
GCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84082
GSE81796_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.987404
SK-MEL-28 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.66
KLF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.706
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.0
Nucleus lentiformis	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.755
GSE93124_0_v_1_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GA-47-MH68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260026
thyroid gland	HPA Tissue Gene Expression Profiles	-1.0	-1.32368
CRCGN016_MCF10A.TP53.M_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.63308
QF-00-NO42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.251176
MFE280	CCLE Cell Line Gene CNV Profiles	1.0	1.39808
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.97917
HSPD1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN016_MCF10A.WT.HP_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.70676
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE123638,GSE123639_2_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF816	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.4957
bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN013_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.15968
CRCGN014_HEPG2_24H:M15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.72201
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93607
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.968097
CRCGN008_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.59355
MZ in posterodorsal (superior) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1818
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.5241
liver	GTEx Tissue Gene Expression Profiles	-1.0	-0.840937
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.932
Lung squamous cell carcinoma_LUSC_TCGA-77-7337-01A-21R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JC-0011-R10A-SM-32PM2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10475
Skin Cutaneous Melanoma_SKCM_TCGA-GF-A3OT-06A-23R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Succinate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.484
170MGBA	DepMap CRISPR Gene Dependency	1.0	2.1153
PMC4815041-NIHMS715090-supplement-Supplementary_Table_10.xlsx-CCF_DP_clustering-Hugo_Symbol_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VJYA-0826-SM-4KL1M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72139
GSE193993_1_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-R55C-1726-SM-3GADJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.78053
Lung adenocarcinoma_LUAD_TCGA-86-8055-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_11_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.30165
GTEX-UJHI-1726-SM-3DB9B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00436
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EY-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE182680,GSE182683_7_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lip	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.928
outer SZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00278
CRCGN009_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-10.0
NFKB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03179
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.35994
PMC6428271-pone.0213813.s007.xlsx-LPS_significant_GOs-ensembl_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-ND-A4WC-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tachyzoite	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.578
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.39302
TF-04-RX73_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.227004
GTEX-O5YU-0008-SM-4E3I7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4997
AA-68-OJ16_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.330172
HCC1395	DepMap CRISPR Gene Dependency	1.0	3.3288
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
KLF11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.7016
ficolin-1-rich granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.886
population	GeneRIF Biological Term Annotations	1.0	null
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.80046
Artery disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.1183
PMC5531310__F3	PFOCR Pathway Figure Associations 2023	1.0	null
ESRRB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2274
GTEX-NPJ7-0011-R10A-SM-2I3E5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.824916
GTEX-S4P3-0426-SM-4AD56	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03348
tRNA (m2G10) methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.685
CRCGN017_MCF10A.WT.HP_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.20405
KLF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.9518
PARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40971
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33836
ERBB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.17583
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24439
hsa-miR-548w	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
phosphoric ester hydrolase activity	GO Molecular Function Annotations 2015	1.0	null
HA-22-CY42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.624983
MDAMB157	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.860203
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	18.9842
QB-88-PG52_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.287592
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CE-96-GH46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.433509
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cranial nerve	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.077
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.67524
RCM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36379
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.7976
central portion of GPi	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.897034
ADP catabolic process	GO Biological Process Annotations 2025	1.0	null
GSE158320,GSE183351_0_v_1_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Epirubicin (hydrochloride)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0181269
GSE157894_1_v_3_cystine_human	RummaGEO Drug Perturbation Signatures	1.0	null
RWPE-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.769
AKTIP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22066
GCT	COSMIC Cell Line Gene Mutation Profiles	1.0	null
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06638
F-actin capping protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.76
PGM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84443
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:F11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.9024
PPP1CB	Pathway Commons Protein-Protein Interactions	1.0	null
regulation of localization	GO Biological Process Annotations 2015	1.0	null
4153_INTS8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.539973
FOSL2	ENCODE Transcription Factor Targets	1.0	null
PMC11696420-41467_2024_55617_MOESM3_ESM.xlsx-Sheet1-Supplementary_Data_1_The_2495_differentially_expressed_genes_between_the_L3MBTL3_knockout_L3-KO4_or_L3-KO5_and_control_C_groups_of_SUM159PT_cells_L3MBTL3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26661
ARMCX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0186
Epirubicin (hydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0151505
Myelencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.866
Cytoplasmic side of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.032
CRCGN015_MCF10A.TP53.M_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.74005
TIGAR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94669
ficolin-1-rich granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.763
CRCGN016_MCF10A.TP53.M_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.01097
6250_PGAM1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-2.22137
CRCGN011_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.54835
GTEX-S3XE-0126-SM-4AD4R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.991956
GSE150049_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PTAR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5048
CRCGN008_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20325
KYSE520	CCLE Cell Line Gene CNV Profiles	-1.0	-1.42316
Lung	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.59097
NHLH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.4848
integument	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
GTEX-SJXC-0726-SM-2XCFJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54336
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RAB5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18609
NCBP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08643
GT1-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.7
BC-14-CG34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261343
Connective tissue	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PLCD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27922
PTP4A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26814
GTEX-S7SE-0011-R10A-SM-2XCDF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908959
urinary bladder	HPA Tissue Protein Expression Profiles	1.0	0.928216
CRCGN016_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.54336
GTEX-XPVG-0008-SM-4GICH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896717
hsa-miR-548d-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
BC-75-FA82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.216626
GPAM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30707
YWHAQ	Pathway Commons Protein-Protein Interactions	1.0	null
GSE123943_4_v_5_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Naproxen_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0242328
proton-transporting two-sector ATPase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.03
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75032
Acute Myeloid Leukemia_LAML_TCGA-AB-2948-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG8-0326-SM-4LVN4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870897
VA-48-RJ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.403713
CRCGN013_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.80528
mitochondrion	LOCATE Predicted Protein Localization Annotations	1.0	null
extracellular region part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
Medulla oblongata	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.866
HNRNPD	Pathway Commons Protein-Protein Interactions	1.0	null
GSE229671,GSE229673_2_v_1_yrdc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Olfactory lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.481
GSE198434_1_v_0_aspirin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cytoplasmic vesicle lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
YA-34-DT48_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277417
Erythromycin_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0181925
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3925
GTEX-QVJO-0011-R10A-SM-2S1QJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16043
GTEX-QEL4-0626-SM-3GIJM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76426
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.7684
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
B-cell lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
H3K27me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN015_HEPG2_48H:P22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.41098
IX, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.90932
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10019
TP73	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.9438
CCDC85C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2567
15833844-Table1S	GeneSigDB Published Gene Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FV-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
X, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.40821
TCF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4678
MDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76759
GTEX-XLM4-0011-R3B-SM-4AT6E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.985474
ZEB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4997
GTEX-RVPU-2426-SM-2XCAR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.03392
Lymphatic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.318
MZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21788
BB-79-AG41_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.53559
CRCGN008_HEPG2_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.1502
CRCGN013_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.0
EJM	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55406
GSE193993_5_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE197630_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
positive regulation of cell motility	GO Biological Process Annotations 2015	1.0	null
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07218
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0796
C1QBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92318
FAM50A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84378
GTEX-R55E-0011-R6A-SM-2TC5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836643
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9192
CRCGN013_HEPG2_24H:A19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.42047
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.0778
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879761
marrow cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
KLK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77323
GTEX-V1D1-0726-SM-4JBH7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27525
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.90284
GTEX-T5JC-2426-SM-3NMDB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837909
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206516,GSE206518_0_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHSB-1826-SM-3TW8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21751
GSE226249_2_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Blood cancer cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.893
PF-59-CY33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.321808
1464_CDYL_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.67478
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8062
CRCGN017_MCF10A.WT.HP_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.75585
respiratory system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
CRCGN015_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63735
CRCGN016_MCF10A.TP53.M_24H:D18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.94469
GNB2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99301
GTEX-XOT4-0008-SM-4B664	GTEx Tissue Sample Gene Expression Profiles	1.0	0.930701
GSE44461_1_v_0_tcf21_human	RummaGEO Gene Perturbation Signatures	1.0	null
Ischemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.114
Lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.292
BF-22-EP86_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.366628
Bisoprolol (hemifumarate)_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0150002
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16052
Prefrontal cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.091
Benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.221
ZKSCAN5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0565
GTEX-OHPM-2626-SM-33HC5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2093
MERO82	DepMap CRISPR Gene Dependency	1.0	2.46428
EEF1A1P5	Pathway Commons Protein-Protein Interactions	1.0	null
estradiol_homo sapiens_gpl6947_gse27375	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-O5YT-1626-SM-32PK6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857759
CRCGN009_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-8.83149
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12491
male	GeneRIF Biological Term Annotations	1.0	null
DC-23-UM36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229464
FOSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.72191
breast	HPA Tissue Protein Expression Profiles	-1.0	-1.15587
HNRNPA0	Pathway Commons Protein-Protein Interactions	1.0	null
GSE161846,GSE161849_1_v_5_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NSL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01726
CRCGN009_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.93755
hsa-miR-3126-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE217452_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2-Phosphoglyceric acid	HMDB Metabolites of Enzymes	1.0	null
BFTC909	DepMap CRISPR Gene Dependency	1.0	2.69071
2973_FARSA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.569839
gracile nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.60162
GSE205163,GSE205164_3_v_7_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE160817_3_v_8_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Naproxen_H4	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.038114
GTEX-X4EO-0526-SM-3P5Z3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12406
Tongue cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.617
Cervical cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.263
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:D22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.24435
CRCGN014_HEPG2_24H:A24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8332
CRCGN015_MCF10A_48H:F21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1665
CRCGN010_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.94238
Afatinib_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0183607
Dmrt1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.4483
CRCGN015_MCF10A.TP53.M_24H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.9175
GTEX-PWO3-0011-R5A-SM-2I5EZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984579
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.02
Erythromycin_LS 180	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0222897
BRI3BP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59069
GTEX-OXRK-1626-SM-3NB17	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.873769
GSE182680,GSE182683_10_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.96044
EA-18-FP00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35197
lateral hypothalamic area, anterior region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.98747
USP54	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.18432
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27871
Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A3MG-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1184	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.51
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5698-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE183327,GSE183328_1_v_0_ddit3_human	RummaGEO Gene Perturbation Signatures	1.0	null
XE-69-AT35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.209237
Parenchyma	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.053
Afatinib_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0163036
FAM110C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00903
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.21861
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.502
GSE211151_1_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193993_4_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
6853_PSMB5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.07966
Azoospermia	HuGE Navigator Gene-Phenotype Associations	1.0	null
ES-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.49204
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5588-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETV5::FIGLA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	41.3395
CRCGN015_MCF10A.WT.HP_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.83605
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	1.0	null
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.17602
GTEX-NPJ8-1926-SM-3MJGB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852988
Cervical ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.154
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE189609_1_v_2_hax1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.78902
CRCGN016_MCF10A.WT.HP_24H:I01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.20196
LMX1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52934
PDE6G	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08147
TCL1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26253
CRCGN009_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7442
CRCGN011_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4222
GSE256181_1_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE171486_4_v_0_ddx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE190384,GSE190386_1_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Naproxen_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.027702
ANKRD10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.52311
positive regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17694
AtT-20 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.715
GTEX-U3ZN-0826-SM-4DXSZ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.974077
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5701-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UQCC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67624
Brain Lower Grade Glioma_LGG_TCGA-HT-7684-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.619
GSE178532_1_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
DENND4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.57904
Oral cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.761
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN014_HEPG2_24H:L18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.91433
HuH-7 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.8
ILF3	Pathway Commons Protein-Protein Interactions	1.0	null
positive regulation of locomotion	GO Biological Process Annotations 2015	1.0	null
CRCGN016_MCF10A.TP53.M_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3922
amygdalohippocampal transition zone, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.58215
Futibatinib_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0113074
7585_RTF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.650515
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TET2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54241
Foxj3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.2084
BF-22-EP86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.332031
Prostate adenocarcinoma_PRAD_TCGA-EJ-7123-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_11_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
parenchyma	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SNX27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38994
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.81722
2538_EIF2B4_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.02607
DUSP26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56904
GRK6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36244
NEUROD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.181
SKOR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22509
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.04462
CRCGN017_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.45515
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.5756
OCRL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23864
germ cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.097407
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
DUSP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95905
GSE224547_1_v_0_cftr_human	RummaGEO Gene Perturbation Signatures	1.0	null
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3474
Ventral pallidus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.875596
Glutaminase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.44
CRCGN017_MCF10A.WT.HP_24H:H10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9274
CRCGN011_HEPG2_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3968
MARK3	Kinase Library Serine Threonine Kinome Atlas	1.0	null
GTEX-SIU7-1826-SM-2XCE2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18995
Idarubicin (hydrochloride)_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.014701
ELAVL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97737
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sperm principal piece	GO Cellular Component Annotations 2015	1.0	null
CRCGN009_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31145
hsa-miR-4276	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
GSE202434,GSE202438_9_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7534
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00474
NEUROD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32131
GSE221327_4_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
Histidine phosphatase superfamily, clade-1	InterPro Predicted Protein Domain Annotations	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Amyloplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.605
GSE157383_3_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.0709
GSE233112_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
thyroid_5b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.26442
GSE153443_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Foxj2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.212
AF-67-LZ82_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.570471
Naproxen_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0206317
JD-81-YX02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.297242
GSE233679_14_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:I03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.13265
GSE182680,GSE182683_5_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-63-A5MR-01A-31R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
blood	GTEx Tissue Gene Expression Profiles	1.0	2.08234
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.5341
GSE182680,GSE182683_0_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AB-64-ZX70_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.545466
H4K20me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE249544,GSE249637_6_v_2_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
8886_THG1L_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.503613
CRCGN015_HEPG2_48H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.82413
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.38167
8903_TIAL1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622024
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BB-42-FF52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23581
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4656
positive regulation of reproductive process	GO Biological Process Annotations 2025	1.0	null
FL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.775
3-Phosphoglyceric acid	HMDB Metabolites of Enzymes	1.0	null
CRCGN013_HEPG2_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.28655
phosphoglycerate mutase activity	GO Molecular Function Annotations 2023	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
lateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.41206
bisphosphoglycerate mutase activity	GO Molecular Function Annotations 2025	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1166
GTF2IRD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19887
NEUROG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.2152
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.028
extracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
CRCGN008_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18995
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.00128
HL60/DNR cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.859
CRCGN009_HEPG2_24H:F19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.3002
MTERF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33149
LOVO	DepMap CRISPR Gene Dependency	1.0	5.65197
IL17C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13817
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.392
8416_SRP68_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.586815
PPARD	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5586
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A268-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.00823
CA-68-KG29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.245126
CRCGN010_HEPG2_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.05153
GSE213588_8_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.31806
FST	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62047
Secretory granule lumen	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
FAM193A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.1702
paraterminal gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.84715
NCI-N417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34167
Quinidine (15% dihydroquinidine)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00391596
Erythromycin_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226859
PALM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17928
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Tear	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.875
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
LB-65-SM65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.439566
CRCGN015_MCF10A.WT.HP_24H:D24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.00862
bisphosphoglycerate 2-phosphatase activity	GO Molecular Function Annotations 2015	1.0	null
CRCGN016_MCF10A.TP53.M_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.42425
JB-75-NC66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.25423
TMEM203	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2204
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M5-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Glioblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.474
Mitochondrial respiratory chain complex I	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.131
FF-86-NH56_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.490432
GTEX-XUYS-0326-SM-47JX2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04775
GTEX-T2IS-0626-SM-32QP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02682
CRCGN014_HEPG2_3H:K16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0692
TAL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22409
143B	CCLE Cell Line Gene CNV Profiles	1.0	1.53103
Lymphoblastoid cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.893
Kidney Chromophobe_KICH_TCGA-KN-8431-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CKB	Pathway Commons Protein-Protein Interactions	1.0	null
C1RL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5375
CRCGN008_HEPG2_24H:L01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4226
CHD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80528
GSE185519_3_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsf1_19179333_rko_colon_carcinoma_lof_human_gpl6244_gse12762	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.58021
GTEX-XUJ4-1026-SM-4BOPB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.944072
CEBPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80217
AA-13-DN24_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.469024
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Plant cell papilla	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.6
CRCGN009_HEPG2_24H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.61878
YWHAZ	Pathway Commons Protein-Protein Interactions	1.0	null
Silodosin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0266048
CRCGN016_MCF10A.WT.HP_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.16614
CRCGN010_HEPG2_24H:A07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87791
CRCGN014_HEPG2_24H:H13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.08553
NKX2-3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.4667
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5639-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN012_HEPG2_24H:J24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.44108
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.1132
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14822
Male reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.526
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
CRCGN011_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.123
Mitochondrial creatine kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.207
REEP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.05389
Pheochromocytoma and Paraganglioma_PCPG_TCGA-P8-A6RX-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBTFL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.22889
AIFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54051
GTEX-QVUS-0226-SM-3GIJY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.50964
GSE240439_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PARP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21377
AE-61-UO01_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.342673
GTEX-NPJ8-2126-SM-3MJGK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.122
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.50665
Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-A9R3-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MPDU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.16912
ZSCAN31	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.5269
Phosphoric acid	HMDB Metabolites of Enzymes	1.0	null
CRCGN015_HEPG2_48H:A24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.21696
GTEX-UTHO-0726-SM-3GAEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57565
Allantoin_SK-MEL-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0190417
CRCGN017_MCF10A.WT.HP_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.22005
NR1D2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.4626
Pancreatic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.728
GSE171837_0_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
shoot	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5263-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE202434,GSE202438_4_v_11_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_3H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.65553
TAF1	ENCODE Transcription Factor Targets	1.0	null
Spot adherens junction	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.503
CRCGN017_MCF10A.TP53.M_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6743
MLH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.45295
anterior orbital gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.01305
KC-32-GO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329711
GTEX-QV31-0726-SM-3GAEG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04034
NCI-H1299 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.772
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
thyroid_5d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.27391
SW1463	DepMap CRISPR Gene Dependency	1.0	4.10696
RBFOX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79902
2541_EIF2S1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.522555
CRCGN015_MCF10A.WT.HP_24H:H19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15866
Sarcoma_SARC_TCGA-3R-A8YX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1684
CRCGN010_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.06341
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.4338
GSE233679_5_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RD-90-OY66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.267268
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-1.18479
Pyruvate kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.136
GTEX-T8EM-1526-SM-3DB7I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02215
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5696-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.10752
6276_PHB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.715561
GTEX-QDT8-0326-SM-32PL1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05471
Kidney Chromophobe_KICH_TCGA-KL-8327-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE135030_8_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-P4PQ-2626-SM-33HC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18717
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Leiomyosarcoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9215
ciliary part	GO Cellular Component Annotations 2015	1.0	null
ut1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.513
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.793
ATPSCKMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8857
Cognitive disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.037
ZNF75A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.7681
GSE222598_1_v_0_sf3b4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62763
POLR2A	ENCODE Transcription Factor Targets	1.0	null
GSE193993_0_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
B-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.316
KCTD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69071
FD-62-ZB67_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285137
CRCGN013_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2112
GTEX-NL3H-0008-SM-4E3HU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17819
Fumarate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.612
Cysteine synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.503
GTEX-S32W-0126-SM-4AD61	GTEx Tissue Sample Gene Expression Profiles	1.0	0.990564
Cytotoxic T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.447
KLHL42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46138
Lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5497
Superior cervical ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.154
PIK3R2	Pathway Commons Protein-Protein Interactions	1.0	null
bad5	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.508
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DC-70-EK34_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.25774
Prostate epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.593
GTEX-TSE9-0426-SM-3DB81	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45888
GSE233548_2_v_0_plscr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158632_3_v_1_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
protein kinase binding	GO Molecular Function Annotations 2025	1.0	null
CRCGN013_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.17326
Idarubicin (hydrochloride)_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0136206
hsa-miR-3154	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
CRCGN016_MCF10A.TP53.M_24H:C18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.6009
TNKS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.50383
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02595
GTEX-Q734-1926-SM-2I5EV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.844509
SMIM30	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71257
LRRC45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71063
CRCGN017_MCF10A.WT.HP_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.36455
VKORC1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24792
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.627723
GSE153871_0_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216540_1_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
2550_EIF3F_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.505287
seminal vesicle	HPA Tissue Protein Expression Profiles	1.0	0.928216
CRCGN014_HEPG2_24H:G20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.14316
GSE150134_1_v_0_fluorouracil_human	RummaGEO Drug Perturbation Signatures	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XP-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-4745-01A-01R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73O-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DETROIT 562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930942
GSE233679_6_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SPTAN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8119
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.2145
GSE216274,GSE216292_4_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.62
CRCGN013_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.7535
184A1N4	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.20123
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.0039
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9304
GSE133763_0_v_1_chd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ARHGAP35	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17222
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.76447
oxoacid metabolic process	GO Biological Process Annotations 2015	1.0	null
CRCGN008_HEPG2_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.66285
CRCGN010_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.2023
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE146840,GSE146842_3_v_2_qrich1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3C7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19464
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051856
SKMEL19	DepMap CRISPR Gene Dependency	1.0	4.76976
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HNRNPAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.35582
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.WT.HP_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.63425
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59741
DNAJC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73808
GTEX-QEL4-0526-SM-3GIJ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18593
Epirubicin (hydrochloride)_SW48	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0109271
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66432
GSE89057_0_v_1_sox5_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.2023
BE-27-XF09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201231
CRCGN009_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.59488
bronchus	HPA Tissue Protein Expression Profiles	1.0	0.928216
GSE180185_9_v_8_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T8EM-1126-SM-3DB7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05765
PMC6428271-pone.0213813.s007.xlsx-LPS_significant_PPIs-node1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00851
PF-59-CY33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.586193
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A6TI-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.508
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.15604
ficolin-1-rich granule	GO Cellular Component Annotations 2025	1.0	null
hsa-miR-92a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
2536_EIF2B2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.509231
GSE192771_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Glycolysis / Gluconeogenesis	KEGG Pathways 2026	1.0	null
NFX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91138
GSE241108_1_v_0_sulfasalazine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
20081105-ST-2	GeneSigDB Published Gene Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-8162-01A-21R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Idarubicin (hydrochloride)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0153156
GTEX-RWSA-0726-SM-2XCBE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18356
Naproxen_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0341031
Glutamate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.664
Erythromycin_LoVo	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0131927
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.18395
NEK9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.69767
GTEX-O5YV-2026-SM-2D7VS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.966742
GTEX-POYW-0008-SM-48TE4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43196
Respiratory chain complex II	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.514
Connective tissue cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
GSE206226_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
carbamoyl-phosphate synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.867
GSE206226_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Futibatinib_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00526128
CRCGN012_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.63757
Epirubicin (hydrochloride)_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.01372
CRCGN015_HEPG2_48H:H22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32359
CRCGN014_HEPG2_24H:N01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49528
CTCF_GM13976_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
USB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14415
NALM16	DepMap CRISPR Gene Dependency	1.0	2.02224
ZC3H12D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.61274
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8QA-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.34993
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.88722
CRCGN016_MCF10A.TP53.M_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.24845
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
k562	HPA Cell Line Gene Expression Profiles	-1.0	-0.896965
brain_a	HPA Tissue Sample Gene Expression Profiles	1.0	1.48854
H3K79me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KD	DepMap CRISPR Gene Dependency	1.0	2.38232
GSE144120_3_v_1_plcg2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BD-61-OO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.875436
6460_PLRG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.529531
CRCGN015_MCF10A.WT.HP_24H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.70369
GSE199092_2_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-920	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
PD-05-HV36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.11276
RELB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.8994
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.88185
CRCGN009_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-8.24661
PTBP1	Pathway Commons Protein-Protein Interactions	1.0	null
Renal carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.595
Naproxen_NCI-H1792	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0340147
CRCGN015_HEPG2_48H:A05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.25875
GSE146982_3_v_5_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Thoracic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.894
TIMM21	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44181
PAICS	Pathway Commons Protein-Protein Interactions	1.0	null
GSE140322_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GE-40-GQ38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251863
EC-62-OE64_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.303277
GTEX-R55G-0526-SM-2TC5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15829
MAZ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	117.726
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169152_5_v_1_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
fh1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.479
efo21	HPA Cell Line Gene Expression Profiles	1.0	0.832456
GSE140997_4_v_6_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
NR4A2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1433
SCCPDH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.62509
Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE199204,GSE211619_4_v_6_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:F20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.8872
Lung squamous cell carcinoma_LUSC_TCGA-77-A5G1-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216043_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Afatinib_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0225657
GSE201309_5_v_0_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CAPAN-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.693
GSE173232_1_v_0_sf3b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF485	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86183
9703_VARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.578065
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DS-A0VN-01A-21R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hematopoietic stem cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.572872
Lymphocytic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.893
LAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77164
hsa-miR-3665	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
AC-36-SY22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208157
SEC22C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14506
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.15404
OB-20-LP90_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.253733
SMCR8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.92235
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.521
GSE234637_2_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-62-OC45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.383226
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.823
Urinary bladder cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.519
GSE225735_0_v_4_aldosterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NCI-H1975 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.558
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	1.0	null
PPP1CC	Pathway Commons Protein-Protein Interactions	1.0	null
GSE182680,GSE182683_0_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EA-69-VJ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.34059
NKX6-1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02165
Vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.322
TXNDC16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9638
CRCGN008_HEPG2_24H:C02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.04535
GSE152734,GSE152735_1_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.47432
NR2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	80.4212
GTEX-R55E-0011-R1A-SM-2TC6N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.852516
lateral tuberal nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02458
GSE95077_1_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN009_HEPG2_24H:N20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51064
GTEX-QEL4-0726-SM-3GIJ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58029
A-2780 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.75
GSE219195_1_v_3_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
DA-81-VY50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.483894
CRCGN013_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.34272
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HUNS1	DepMap CRISPR Gene Dependency	1.0	3.18226
CRCGN012_HEPG2_24H:G05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.07836
GTEX-PVOW-0426-SM-2XCF8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95018
Melanoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.527
single-organism carbohydrate metabolic process	GO Biological Process Annotations 2015	1.0	null
BF-49-KQ10_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235829
Midbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.959
ASCL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.8528
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.887369
hsa-miR-940	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GPATCH11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.86556
ETNK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33914
Atrial heart septal defect 1	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.063
Pancreatic ductal carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.914
SBF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.80218
PKM2 pyruvate kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.822
KLF15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	158.794
AE-71-CB15_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238554
GSE239844_6_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47685
GSE186287_1_v_3_ufm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.12005
CRCGN015_HEPG2_48H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.02193
ZYG11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48016
single-organism carbohydrate catabolic process	GO Biological Process Annotations 2015	1.0	null
HDAC11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54699
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LRFN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56189
GTEX-RM2N-0008-SM-48FF3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35919
HNRNPUL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00588
KIF5A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78909
extracellular region	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE233647_2_v_3_docetaxel_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:P07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.65536
HCC-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-WCDI-0008-SM-47JYE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50999
CRCGN015_MCF10A.WT.HP_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.25252
CRCGN014_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.604
INF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.09865
TMEM14A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.64407
RUNX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56995
GTEX-RWS6-0826-SM-47JXF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864226
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052069
6855_PSMB6_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.15333
RFX5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.0535
CRCGN009_HEPG2_24H:M19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.07625
Abdomen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.242
eRF1 methyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.68
COQ8A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51311
GSE119978,GSE180930_6_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
106_ACTL6A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.503672
Vascular system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.242
GSE154577_13_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pancreas disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.686
OC-10-FB51_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208799
Brain cortex cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
YE-46-YA12_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.534189
AE-07-IZ32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.380925
AE-85-KE62_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.444636
CRCGN014_HEPG2_24H:N17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01102
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.27165
Left ventricle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.004
Lung carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.78
PMC11214527-mmc5.xlsx-TP53-gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A9WH-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:L17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.73512
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.5627
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
BASP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PVOW-1026-SM-2XCF9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.879119
Trigeminal ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
PMC4387713-supp_gad.255984.114_Table_S4.xlsx-S4A-Down_Nanog_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Sympathetic nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.154
ZNF274	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18775
CRCGN009_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.94614
CRCGN014_HEPG2_24H:F01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01314
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.59469
Lung adenocarcinoma_LUAD_TCGA-35-4123-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.34594
ZNF717	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52355
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.04575
Lung adenocarcinoma_LUAD_TCGA-55-8090-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
locus ceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.44318
CRCGN012_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2869
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.49322
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.24899
GSE205163,GSE205164_3_v_6_znf808_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CaSki cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.705
GC-04-UF36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.961935
NDUFS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.38609
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07925
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.866525
RAB11B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40808
CRCGN015_HEPG2_48H:H23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.31927
bronchial epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-XUJ4-0126-SM-4BOP7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855392
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9004
VPS52	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0079
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M8-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	1.0	2.93379
GTEX-QDVJ-0426-SM-2I5FW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826368
WC-09-GD62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.81396
MEIS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.7539
PK-15 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.567
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.833
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MS-0011-R2a-SM-2HML6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14462
GSE219195_0_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Epirubicin (hydrochloride)_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0372559
GSE161846,GSE161849_1_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03417
regulation of locomotion	GO Biological Process Annotations 2015	1.0	null
496100421_PCx_probable Alzheimer's disease_TBI_88_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.04368
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TG-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE132408_1_v_3_tet2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QLQW-1326-SM-2S1QS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970754
KINGS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.421
GSE193351_1_v_0_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.832152
Lung squamous cell carcinoma_LUSC_TCGA-34-5241-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ovary epithelial cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.039
TBC1D10A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66846
GSE167956_1_v_0_trim28_human	RummaGEO Gene Perturbation Signatures	1.0	null
BB-27-MC77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.263908
CTSK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03232
midbrain raphe nuclei	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.923425
GTEX-XBED-2626-SM-4E3J5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63193
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.94985
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HY-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRACR2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02303
GUSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42976
Iloprost	DeepCoverMOA Drug Mechanisms of Action	1.0	0.5
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3346-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_3H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.06954
RPN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69344
Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T2-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adenocarcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0968
GTEX-NPJ8-0011-R1a-SM-33HCB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.924848
8599_SUPT6H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.658826
H3K36me3_cardiac mesoderm_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6X4-01A-51R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cerebral peduncle	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.959
PSPC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12143
male reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.982636
CRCGN017_MCF10A.TP53.M_24H:G12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.24155
MANEA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.62891
Neurofibrillary tangle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.103
FF-28-ES17_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222388
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15454
Afatinib_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0122383
CRCGN013_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.26687
Lung squamous cell carcinoma_LUSC_TCGA-66-2768-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HC-92-HE59_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290405
Extrinsic component of cytoplasmic side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.01
FRAT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48679
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
2549_EIF3E_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.14994
PPP1R3D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76875
CRCGN016_MCF10A.TP53.M_24H:D20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55886
CRCGN016_MCF10A.WT.HP_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69113
CRCGN015_MCF10A_48H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.00343
CRCGN009_HEPG2_24H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01457
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.8931
CRCGN014_HEPG2_24H:J13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.33246
CRCGN015_MCF10A.WT.HP_24H:P02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.04117
WT-8 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.689
Hepatobiliary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.857
CRCGN017_MCF10A.TP53.M_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.28396
Myeloid leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.132
DA-33-BM26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.280056
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23083
CRCGN013_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1171
ZNF461	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.42581
WC-09-GD62_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.19286
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.723798
basomedial nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.30115
CALR	Pathway Commons Protein-Protein Interactions	1.0	null
Naproxen_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0255619
JC-63-BE61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.390461
CRCGN008_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5829
PRKCB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49644
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68219
red nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.57065
MSANTD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2809
GSE185519_3_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
wehi164	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.555
GSE121866_1_v_3_six4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
TSG101	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.08244
ZNF343	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	53.9935
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.6591
GSE211128_3_v_5_angptl4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221633_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	1.0	null
PD-70-VS77_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291693
IARS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.73886
NCIH1963	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48857
glycolytic process	GO Biological Process Annotations 2023	1.0	null
RB-34-TO07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28267
CRCGN017_MCF10A.TP53.M_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55293
Idarubicin (hydrochloride)_RPMI-7951	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0177915
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.31815
SPIB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.9026
hematopoietic system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
BIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42502
CRCGN012_HEPG2_24H:G04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.56314
19088021-supptable2	GeneSigDB Published Gene Signatures	1.0	null
GSE205730,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TSE9-0526-SM-3DB7Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48424
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BB-39-YQ35_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.223738
GSE215086_8_v_6_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148096_1_v_0_erlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
male reproductive gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.545739
glycerol-3-phosphate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.12
catalytic activity	GO Molecular Function Annotations 2015	1.0	null
HIST1H1T	Pathway Commons Protein-Protein Interactions	1.0	null
Motile cilium	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
BL2429 (NCOA4)	NURSA Protein Complexes	1.0	null
GSE235390_4_v_2_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.TP53.M_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.01048
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3357-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.26008
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19Q-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55105
Norepinephrine (hydrochloride)_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0188772
GTEX-T8EM-1326-SM-3DB7G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.37272
GADD45A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.72031
METAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06775
leaf	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
Integumentary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.14
CRCGN012_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.27394
CRCGN014_HEPG2_3H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41169
GSE168797_4_v_5_cannabidiol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:E11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.45732
5462_NAPA_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.577587
GB-73-QS80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.603562
CRCGN013_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.74038
Glycine, serine and threonine metabolism	KEGG Pathways 2026	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.31006
IA-76-ZU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.228966
VPS45	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99373
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.36295
GSE243879_1_v_0_elapor1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TTYH3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64705
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.45685
GTEX-U3ZN-1726-SM-4DXUQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.927881
PMC10265544-supplementary_table_1.pdf-2-JUN_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OIZG-1026-SM-3LK5X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.970249
Glyceric acid 1,3-biphosphate	HMDB Metabolites of Enzymes	1.0	null
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.15587
GA-88-CF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.850121
CRCGN015_HEPG2_48H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52848
LIN37	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35285
PDE6D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85547
vagina	HPA Tissue Protein Expression Profiles	-1.0	-1.15587
GSE154577_6_v_5_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE133087_1_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:L24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.14052
Idarubicin (hydrochloride)_SNU-423	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0145388
MBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.37547
GSE178340_5_v_2_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102505_6_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.1455
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29V-06A-12R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cytoplasmic vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.167611
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.53
SNRPF	Pathway Commons Protein-Protein Interactions	1.0	null
Sarcoma_SARC_TCGA-HS-A5NA-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Blood cancer cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
1346_CCT2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.510029
9680_UTP14A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.667421
CRCGN012_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41932
Futibatinib_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0118091
Glycolysis	PANTHER Pathways	1.0	null
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193993_4_v_2_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
TAF4B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6493
GSE128844_0_v_2_chloroquine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF317	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9944
MDH2	Pathway Commons Protein-Protein Interactions	1.0	null
intramolecular phosphotransferase activity	GO Molecular Function Annotations 2025	1.0	null
KMT2D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60722
PTGES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.99797
CRCGN016_MCF10A.WT.HP_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.37189
Liver hepatocellular carcinoma_LIHC_TCGA-T1-A6J8-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.4889
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14681
GTEX-POMQ-0326-SM-2I5FO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.841958
GSE160817_7_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.70534
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35537
NB120-3333 (PSME3)	NURSA Protein Complexes	1.0	null
GTEX-V955-0326-SM-4JBGV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947438
BB-62-SZ35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.08084
GSE190076_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.48665
ZNF677	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1183
CRCGN012_HEPG2_24H:N19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.00726
GTEX-PWO3-0011-R3A-SM-2I5EX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934595
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE176008_0_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18738
GTEX-Q2AH-0008-SM-48U2J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34463
PAK1	Hub Proteins Protein-Protein Interactions	1.0	null
Lateral entorhinal cortex	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.598
vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
ENO1	Pathway Commons Protein-Protein Interactions	1.0	null
Bisoprolol (hemifumarate)_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0159326
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.72686
catabolic process	GO Biological Process Annotations 2015	1.0	null
GSE172189_0_v_1_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
GRHL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5087
DD-43-WW40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.23057
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.8953
GSE249544,GSE249637_9_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
QPCT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41321
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.93532
SMARCA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82628
AD-18-XC14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208797
CRCGN016_MCF10A.TP53.M_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98148
LDHB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
MZ in primary somatosensory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.1784
blood	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
EE-18-HW72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.339819
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A113-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126463_6_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POTEE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14004
BE-79-QU25_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.628221
GTEX-U3ZH-1926-SM-4DXTR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91226
cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
H2BC12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79144
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55302
ATOH8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.43052
hypocotyl	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10695
GSE211215_1_v_0_akr1b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE199092_3_v_0_ddx5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20X-01A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Epirubicin (hydrochloride)_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0190677
ADNP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46339
CRCGN015_MCF10A.WT.HP_24H:F23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.83341
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hsa-miR-3149	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Bisoprolol (hemifumarate)_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0161067
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.988914
GSE66014_0_v_1_perhexiline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.9859
GSE223609,GSE223610_0_v_1_kdm6a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MES-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.505
cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
GSE193993_1_v_3_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P78B-1626-SM-2S1O1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.975
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.718
DMS 273	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.20554
Hmga1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.6363
TAS2R5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88722
Subthalamic nucleus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.93
Mitochondrial pyruvate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.824
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.844411
GA-87-BR97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.625312
CRCGN013_HEPG2_24H:L07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.63626
Lung adenocarcinoma_LUAD_TCGA-64-5775-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE195568_3_v_7_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Ornithine carbamoyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.654
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.512244
GSE126776_0_v_1_pelp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RN64-0326-SM-2TC5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.993898
CRCGN015_MCF10A.WT.HP_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.28533
CRCGN015_MCF10A_48H:F12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.32706
Kidney renal clear cell carcinoma_KIRC_TCGA-CW-5581-01A-02R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GB-11-TA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210327
CRCGN014_HEPG2_3H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11844
CRCGN016_MCF10A.TP53.M_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.15057
CRCGN016_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.88842
GTEX-P4QS-1026-SM-3NMCW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16072
CC-68-YZ44_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.396172
CRCGN010_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.18605
retrogene	GeneRIF Biological Term Annotations	1.0	null
LYL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29617
RASSF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02015
EVSA-T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.76207
Stomach cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.438
GSE193258,GSE193259_5_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A_48H:D16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.27934
FD-15-HD09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200105
Heterotrimeric G-protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.011
Helper T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.551
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4856-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
vertebrate muscular system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.042717
Erythromycin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0301823
C75	DepMap CRISPR Gene Dependency	1.0	2.30037
GSE142630_0_v_2_hiltonol_human	RummaGEO Drug Perturbation Signatures	1.0	null
8921_TIMM23B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.505224
FOXI3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.5394
GTEX-OOBK-1626-SM-2HMKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11943
OB-06-WW76_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.35132
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A953-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146982_4_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
QA-50-YO37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.930565
IA-76-ZU47_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291449
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.6715
PMC9124206-41419_2022_4940_MOESM8_ESM.xlsx-DEG_PACA-US-ID_PTF1A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55C-0326-SM-3GAF1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16902
CCDC107	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.11529
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01005
AE-95-UU45_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.610573
BL3038 (ERBB4)	NURSA Protein Complexes	1.0	null
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88945
USP24	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02449
TE5	CCLE Cell Line Gene CNV Profiles	-1.0	-3.21049
Respiratory epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.311
Side of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.977
7842_SFPQ_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.611599
PTW/PP1 phosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.594
Sarcoma_SARC_TCGA-HB-A2OT-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MZ in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.03177
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-P4PQ-0626-SM-3NMCU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879082
Prostate disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.514
MDAMB361	CCLE Cell Line Gene CNV Profiles	-1.0	-1.94281
MYH14	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4866-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.31575
CRCGN012_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.32605
Head and neck squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.191
GTEX-QDVJ-0726-SM-48U1W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910115
5811_NRF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.26637
6740_PREB_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.09438
DD-26-VR55_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345264
CRCGN017_MCF10A.TP53.M_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.27603
CRCGN010_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7288
CRCGN010_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.24695
Uterine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.332
Caudate nucleus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.856
GTEX-XPVG-2526-SM-4B66D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12374
GSE132369,GSE132371_4_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:J10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8203
GSE219195_4_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Erg	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.6215
BC-13-OQ01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24765
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4734-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.78925
SCABER	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80284
TTC19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.50221
Primary hematopoietic stem cells G-CSF-mobilized Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-1.12418
GF-35-IT27_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.376082
GSE95077_5_v_0_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PF-382	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GID8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7728
15505275-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
plant embryo	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
SPIN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.91915
Idarubicin (hydrochloride)_HEC-1-A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0241887
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.527591
VA-06-DB75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.460181
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Amnion epithelial cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.715
Erythromycin_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0137142
RCC 786-O cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.545
coding	GeneRIF Biological Term Annotations	1.0	null
CRCGN016_MCF10A.WT.HP_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06988
CRCGN012_HEPG2_24H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.9737
GTEX-V1D1-2426-SM-3GAER	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.39092
CRCGN008_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1123
WE-43-PZ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.208772
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4217-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-A5SS-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE218727_2_v_1_zkscan3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Afatinib_J82	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0214599
CRCGN016_MCF10A.WT.HP_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.07321
ZNF565	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59642
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81621
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.95944
NAMALWA	DepMap CRISPR Gene Dependency	1.0	2.79182
HNRNPU	Pathway Commons Protein-Protein Interactions	1.0	null
OV7	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.869402
GSE199204,GSE211619_4_v_2_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Dexmedetomidine_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0140571
GSE157296,GSE157298_4_v_3_kbtbd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EEF1A2	Pathway Commons Protein-Protein Interactions	1.0	null
IGR1	CCLE Cell Line Gene CNV Profiles	1.0	2.50242
hsa-miR-548i	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE235605,GSE235701_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-W5WG-2326-SM-3GIJH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894046
RGS11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21761
Naproxen_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.041225
GTEX-WXYG-2526-SM-3NB3F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.08482
spermatogonium	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.182651
SYNCRIP	Pathway Commons Protein-Protein Interactions	1.0	null
extracellular organelle	GO Cellular Component Annotations 2015	1.0	null
RTF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81862
PRDX6	Pathway Commons Protein-Protein Interactions	1.0	null
FD-91-OK66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.242129
BPNT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27341
LBR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56337
Erythromycin_SW480	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0245027
SUDHL1	CCLE Cell Line Gene CNV Profiles	-1.0	-2.19368
SZ in rostral cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25796
Fibre tract	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.959
Erythromycin_NCI-H23	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.018533
GTEX-S4P3-0226-SM-3K2BD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870413
CRCGN015_MCF10A.WT.HP_24H:I14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.54209
ZFR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57356
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WP-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OXRK-1826-SM-2HMJE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03589
ATP metabolic process	GO Biological Process Annotations 2025	1.0	null
CRCGN014_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43043
Male infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.274
GSE235516_0_v_1_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAX1BP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.90643
CRCGN014_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-10.0
CRCGN014_HEPG2_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.05567
GTEX-OHPL-1626-SM-2HMIR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.862862
GTEX-QVJO-0126-SM-3GIK4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.50964
FM3A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.835
cancer-infiltrating inflammatory cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.03
GSE232624_4_v_5_ethanol_human	RummaGEO Drug Perturbation Signatures	1.0	null
DDX55	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.04935
Pentoxifylline_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.016098
CRCGN016_MCF10A.TP53.M_24H:L11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.15541
ZBTB18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.374
ERAL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.47215
glucose catabolic process to pyruvate	GO Biological Process Annotations 2025	1.0	null
BE-49-XN43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251219
Tauopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.178
CAL-51 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.818
BAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66013
Erythromycin_HepG2/C3A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0203299
NT5DC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94291
GSE184399_0_v_3_cnot1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PLK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.1215
COLO824	DepMap CRISPR Gene Dependency	1.0	3.86288
GSE199543,GSE239447_0_v_4_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.79005
FOS_01_99	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59205
interpeduncular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.95984
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4962-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0066
CRCGN016_MCF10A.TP53.M_24H:N14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.25195
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
GSE211262,GSE211263_0_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11408518-41598_2024_73146_MOESM5_ESM.xlsx-Intersection_gene-NCOA1_NCOA1	Rummagene Transcription Factor Associations 2026	1.0	null
CPS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00659
hsa-miR-548y	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.474
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
Overnutrition	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
FBXO33	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06775
UMNSAH/DF-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.665
GSE142588_2_v_3_cinobufagin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Globus pallidus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.755
CRCGN014_HEPG2_3H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.21394
High grade glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.489
17409455-TableS2	GeneSigDB Published Gene Signatures	1.0	null
BCPAP	DepMap CRISPR Gene Dependency	1.0	5.41271
GTEX-XBED-1026-SM-48TCB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.960352
GB-73-QS80_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.497596
TKKK	DepMap CRISPR Gene Dependency	1.0	2.29881
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09198
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KQ-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GB-57-XV52_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.233068
ZNF222	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.36253
ZNF780B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.69953
Malignant exocrine pancreas neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.506
GSE160817_4_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nectary parenchyma	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.961
zona incerta, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.5241
Biliary tract cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.058
DD-71-LY65_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201262
HPS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7006
GTEX-P4QS-0326-SM-2I3EU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25267
ZNF667	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.9755
Epirubicin (hydrochloride)_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226325
SKLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.81222
GSE148200_3_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymphatic system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
GSE140997_10_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Idarubicin (hydrochloride)_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0162745
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.558647
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A5GL-06A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRAPPC2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12221
Bisoprolol (hemifumarate)_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0196278
DKMG	DepMap CRISPR Gene Dependency	1.0	4.45159
KB-92-MK13_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226552
ZNF148	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	143.046
HUH7	CCLE Cell Line Gene CNV Profiles	1.0	1.79051
LJI308_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.00507858
GTEX-R55E-0526-SM-2TC6B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13357
amygdala	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE226249_2_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:B10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5453
DTD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94929
carbohydrate catabolic process	GO Biological Process Annotations 2023	1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.448405
CTCF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	211.485
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	1.0	2.69941
EOMES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51252
PMC6428271-pone.0213813.s007.xlsx-LPS_anti-IL-10_significant_PPIs-node1_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
Batlung	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.065
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.859918
intramolecular transferase activity, phosphotransferases	GO Molecular Function Annotations 2015	1.0	null
Neck	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.341
GTEX-R53T-1826-SM-3GIJX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.37298
CRCGN012_HEPG2_24H:G19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.40416
GSE239844_4_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1395	CCLE Cell Line Gene CNV Profiles	-1.0	-1.55261
GSE246567_0_v_1_acat2_human	RummaGEO Gene Perturbation Signatures	1.0	null
PK-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.48094
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Glycyrrhizic acid_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0182934
MOLM14	DepMap CRISPR Gene Dependency	1.0	2.75083
CCT5	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN009_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28643
PMC12271601-mmc2.xlsx-OUT_cells_02-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.978253
Endocrine pancreas	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.549
CRCGN009_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.50334
CRCGN009_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.31279
Hoxa13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.8239
Skin	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Phosphoglycerate mutase 1	InterPro Predicted Protein Domain Annotations	1.0	null
ZNF770	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	97.4025
JHOS4	CCLE Cell Line Gene CNV Profiles	1.0	3.2803
CRCGN017_MCF10A.WT.HP_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.09545
CRCGN015_MCF10A.TP53.M_24H:I05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.80616
Chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61633
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.25
TMEM222	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56161
CRCGN017_MCF10A.WT.HP_24H:E10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.896
extracellular region part	GO Cellular Component Annotations 2015	1.0	null
GSE217552_3_v_5_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CDKN1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49067
HEPA 1-6 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.774
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.28132
hsa-miR-92b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
ARHGAP39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2901
CRCGN016_MCF10A.WT.HP_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.995
TA-34-CK62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.292244
ATP1B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26008
POU1F1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83437
HCC827	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.02439
PATU8902	DepMap CRISPR Gene Dependency	1.0	3.43008
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CENPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20034
hsa-miR-3692	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GTEX-SN8G-0526-SM-32PLE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941693
GTEX-OXRO-0011-R2A-SM-3NB1W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28574
CRCGN008_HEPG2_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.58885
GTEX-OHPL-0008-SM-4E3I9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15708
CRCGN014_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.11239
Acute Myeloid Leukemia_LAML_TCGA-AB-2813-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE200839,GSE233826_5_v_6_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IZ in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21851
Heart disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.144
CRCGN009_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8264
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7890-01A-12R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3447-01A-01R-1766-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Ivabradine (hydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0253674
CB-20-ND22_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217502
CRCGN014_HEPG2_3H:J18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59319
NSUN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.777
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962299
bronchial epithelial cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-T8EM-0226-SM-3DB7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869326
GTEX-QXCU-0008-SM-48FCH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31679
GSE214842_0_v_1_atf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
chinese	GeneRIF Biological Term Annotations	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.28035
3632_HARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.64715
GTEX-TMMY-0526-SM-33HBC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44804
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.54747
bone marrow	HPA Tissue Protein Expression Profiles	-1.0	-1.15587
Epirubicin (hydrochloride)_HepG2/C3A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0130164
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0843
Amniotic cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.695
Naproxen_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0409052
XC-81-LR46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375016
IGFBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39662
AC-30-XU83_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.12011
Hematopoietic cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.893
GSE158834_11_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.76198
RFXANK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37208
dorsal lateral geniculate nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17361
GTEX-T5JC-0011-R8A-SM-32PLM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907377
Avian pallium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.151
PGAM2	Pathway Commons Protein-Protein Interactions	1.0	null
heart	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
Naproxen_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0318964
GTEX-X261-0326-SM-3NMD4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34719
SOHLH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8562
ZNF787	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.24547
hsa-miR-367	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
SNU-398 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.956
GSE173232_4_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WYVS-2326-SM-3NMAI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00197
HG3	DepMap CRISPR Gene Dependency	1.0	2.96524
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	1.0	2.44147
PIGO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88012
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE126463_1_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ascites	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.242
CRCGN012_HEPG2_24H:D01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.11514
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.969501
plant	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
bisphosphoglycerate mutase activity	GO Molecular Function Annotations 2015	1.0	null
rectum	HPA Tissue Protein Expression Profiles	1.0	0.928216
CRCGN015_HEPG2_48H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.95141
GSE126463_5_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE239844_6_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.41992
GTEX-S4UY-0526-SM-3K2AN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955858
VRK2	Kinase Library Serine Threonine Kinome Atlas	1.0	null
DUSP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02006
GSE95386_0_v_1_trim24_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A0YX-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.545
DNLZ	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94159
RABGAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72434
KLN205 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.07
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.7118
KBTBD11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60327
CHD1	ENCODE Transcription Factor Targets	1.0	null
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CEP170B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04892
DHX30	Pathway Commons Protein-Protein Interactions	1.0	null
GSC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38134
TFAP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52792
5888_NUP155_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.768336
CEL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09549
COPS7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49322
RWDD2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.45785
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6955-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4446
PLOD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93347
GSE166920_6_v_4_adalimumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
Hematopoietic system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.407
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.19154
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.78292
a431	HPA Cell Line Gene Expression Profiles	1.0	2.11552
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11773
CRCGN012_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3297
MMP15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97794
Glucose transporter complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.155
GSE206516,GSE206518_3_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE168602,GSE168604_2_v_1_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8052
GSE233679_6_v_1_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SLX1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8874
Breast disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.902
ME-180	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.978253
secondary spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.194604
PCBP3	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-JX-A3PZ-01A-11R-A32Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JAM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.02177
phosphatase activity	GO Molecular Function Annotations 2015	1.0	null
PIGH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.60558
phagocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
hsa-miR-299-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Osteosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
REM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14913
IKZF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.23779
H1 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.248
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-R55F-1526-SM-2TF4X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32702
Hoxd13	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.6366
Cytoplasmic ubiquitin ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.842
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.513
CRCGN010_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2168
OSR2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9945
AD-16-HL96_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.634395
temozolomide_homo sapiens_gpl10558_gse43452	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Large cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.764
CRCGN014_HEPG2_24H:P01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36517
CRCGN014_HEPG2_24H:J15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.31865
Prostate adenocarcinoma_PRAD_TCGA-2A-A8W1-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DE-98-FC24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.554587
GTPBP4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.448
Hepatobiliary disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.824
GORAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04719
ZD-18-MI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.306674
SC-25-HE80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203052
NEUROG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18125
ELF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76532
CRCGN011_HEPG2_24H:K13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-10.0
GSE182680,GSE182683_7_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BT474	CCLE Cell Line Gene CNV Profiles	-1.0	-1.40144
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.18358
Central nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.508
JUND_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LC-12-VN85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239302
CRCGN015_MCF10A.TP53.M_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.35425
DNAJC28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59578
CRCGN014_HEPG2_3H:G08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.25197
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE146982_3_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Monogenic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.192
foxa1_23539448_lncap_lof_human_gpl10558_gse37314	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.050756
DF-84-RT50_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.34029
GTEX-RNOR-0926-SM-2TF56	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65291
NOP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82855
ZNF675	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.9717
CHST2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65147
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-1596-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTPN18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29775
AA-68-OJ16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.495214
CRCGN016_MCF10A.TP53.M_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.6527
CRCGN008_HEPG2_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.1436
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-A6W5-01A-12R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HIST1H1A	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.88689
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.95155
CRCGN009_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.26415
Glycogen metabolism disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
2658_EP400_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.761909
FOS::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1165
GMEB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12045
GTEX-T2YK-2226-SM-32QPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.928804
FE-10-KQ78_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231641
outer SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.83419
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J6-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBE2Q2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40836
GTEX-W5WG-1926-SM-4KKZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32172
HAUS5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30281
CRCGN008_HEPG2_24H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09395
NFATC3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.5279
Pancreatic ductal adenocarcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.651
CRCGN015_MCF10A.WT.HP_24H:E16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.45608
PMC7522570__F8	PFOCR Pathway Figure Associations 2023	1.0	null
PBX1-22567123-OVCAR3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WI-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
midbrain reticular formation	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.972245
GSE233679_14_v_0_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE142210_4_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MYL6	Pathway Commons Protein-Protein Interactions	1.0	null
SPOTS complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.112
CLOCK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1557
GSE158632_2_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC2911	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.951354
3086_FIP1L1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.530949
SNRPB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56577
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
sex	GeneRIF Biological Term Annotations	1.0	null
GTEX-PX3G-0008-SM-48U2L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4621
FB-66-UU47_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.520878
GTEX-VUSG-2626-SM-4KKZI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22889
hsa-miR-3664-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
UBE2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39395
GSE111247_11_v_3_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BT-474 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.86
Pectoral muscle	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.213
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	145.01
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.84045
CRCGN014_HEPG2_3H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22715
GSE158834_1_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193993_0_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHLA57	DepMap CRISPR Gene Dependency	1.0	3.72166
GSE211215_1_v_0_pemetrexed_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
CRCGN008_HEPG2_24H:H02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.58775
KLHDC10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.32471
CRCGN010_HEPG2_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34149
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TYRO3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0017
EDA2R	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.54459
Myc-CaP cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.612
escape	GeneRIF Biological Term Annotations	1.0	null
GTEX-OXRN-1326-SM-3LK5V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72752
FOXRED1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79371
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.946024
Breast cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.895
CRCGN016_MCF10A.TP53.M_24H:P16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.42145
ED-32-VE54_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.386596
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SM-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CC-03-PW00_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200254
CPLANE2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29269
RAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41205
CRCGN012_HEPG2_24H:J22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.68301
PPP1CA	Pathway Commons Protein-Protein Interactions	1.0	null
myeloid progenitor cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.572872
GSE202434,GSE202438_4_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lymph	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	3.867
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ELF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2573
ZNF71	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.00824
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4018
NEURL1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.66833
gallbladder	HPA Tissue Gene Expression Profiles	-1.0	-0.867678
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QESD-1626-SM-2S1RB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11886
Intrinsic cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
Sperm principal piece	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
SLC30A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85873
GSE227592_13_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
HNF4A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.3206
CD7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.946
7734_SEC13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.569341
ARHGAP5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.79696
PIGM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77893
CRCGN010_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65327
AF-16-IB77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238994
Thalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.102
CRCGN017_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.66213
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01097
GA-59-RW04_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-2.18269
cytoplasmic membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.170371
GATA5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9992
muscle	GTEx Tissue Gene Expression Profiles	-1.0	-1.89899
hsa-miR-3614-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
ARHGEF39	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79003
XB-53-OZ95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.209079
FGF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17104
Serine C-palmitoyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.062
GSE200839,GSE233826_5_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Glycine cleavage complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.241
Afatinib_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0164016
Malignant astrocytoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.471
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-REY6-1326-SM-48FDO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.887781
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ELN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24352
CAPRIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06757
SNUC1	CCLE Cell Line Gene CNV Profiles	1.0	1.58525
HO-1-U-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SIHA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.81558
RBM34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18577
TFDP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9716
MIF	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN008_HEPG2_24H:G01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.06895
Paraspeckles	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.699
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GFPT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44816
MD-17-VD78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.291979
HS-Sultan cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.893
3978_HSPA5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.35385
MM485	DepMap CRISPR Gene Dependency	1.0	7.72895
GSE217552_3_v_0_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE248935_1_v_0_cd14_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE181431_0_v_1_calr_human	RummaGEO Gene Perturbation Signatures	1.0	null
Epirubicin (hydrochloride)_SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0161902
MZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.13586
DOLPP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23042
CRCGN013_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.47587
ZBTB7B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	101.884
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
1774_COPG1_P1	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.60408
CRCGN015_MCF10A.TP53.M_24H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-10.0
BF-29-LU75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278387
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13735
Brain Lower Grade Glioma_LGG_TCGA-HT-8113-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.77194
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.860844
membrane-bounded vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.168847
ADAR	Pathway Commons Protein-Protein Interactions	1.0	null
basal nucleus of Meynert	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.999139
disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.041945
PMC5129526__F1	PFOCR Pathway Figure Associations 2023	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.22077
Ovarian cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.418
2-Phospho-D-glyceric acid	HMDB Metabolites of Enzymes	1.0	null
GSE129241_3_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
SIDT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.25938
skeletalmuscle_b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.27495
HSP90AB1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2428
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
membrane-bounded vesicle	GO Cellular Component Annotations 2015	1.0	null
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:K04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.22443
PMC7522570__F8	PFOCR Pathway Figure Associations 2024	1.0	null
BD-96-HO33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.553762
NDUFS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5249
GSE231875_0_v_1_zbed3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
BA-19-VU85_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.673058
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.72215
HCFC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.14239
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.08251
positive regulation of flagellated sperm motility	GO Biological Process Annotations 2025	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.95226
TD-48-XJ84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235063
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.79889
ZNF852	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84741
Plasma membrane bounded cell projection	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
CRCGN009_HEPG2_24H:C01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.3662
PPM1F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76344
Naproxen_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0316549
CRCGN009_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2154
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4154-01A-01R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:G24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.4118
5339_MTOR_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.515496
paracentral lobule, anterior part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.09654
GE-54-IF41_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203357
HBL-100 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.579
Lung adenocarcinoma_LUAD_TCGA-05-4415-01A-22R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04607
GTEX-PWO3-0011-R6A-SM-2I5F3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04596
Erythromycin_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0188105
CRCGN017_MCF10A.WT.HP_24H:J07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.6966
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.92092
testis	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.743801
ZNF547	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.46
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.25434
FHIP2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.29821
CENPW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82464
SKNFI	DepMap CRISPR Gene Dependency	1.0	4.34804
CRCGN017_MCF10A.TP53.M_24H:J01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.5812
CLEC14A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26651
CHCHD5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20336
GSE81796_0_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VMRCLCP	CCLE Cell Line Gene CNV Profiles	1.0	2.09602
GTEX-WL46-2926-SM-3LK82	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825177
GTEX-S341-1826-SM-3K2AB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22163
IQGAP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.53631
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.528589
GTEX-X5EB-2326-SM-46MW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.74216
GSE193351_1_v_3_ruxolitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Occipital pole	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.561
GTEX-T5JW-0226-SM-4DM7I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.846453
sperm principal piece	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MEPCE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.44463
COPS9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8171
ECH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24605
Uterine leiomyoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.922
CRCGN009_HEPG2_24H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.8352
SKBR3	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.826121
TMEM219	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64757
cilium	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
stem	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
glycolytic process through glucose-6-phosphate	GO Biological Process Annotations 2025	1.0	null
medial portion of STH	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.898036
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86333
MARCKS	Pathway Commons Protein-Protein Interactions	1.0	null
GSE213588_8_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EEF1A1	Pathway Commons Protein-Protein Interactions	1.0	null
AA-58-FJ71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.661706
ADAM8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14073
GSE146982_3_v_5_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bronchial epithelial cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.311
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6232
monocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Cell trailing edge	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.534
CRCGN015_HEPG2_48H:E17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.05743
CA-66-FY97_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.516587
GABPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5812
GTEX-XYKS-2426-SM-4AT43	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11694
ZE-45-CG69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.318336
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7265
SLC35E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12272
GTEX-WL46-0626-SM-3LK7R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13287
metabolic process	GO Biological Process Annotations 2015	1.0	null
FE-64-KC49_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.498052
INSM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63333
EJM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930942
Endocervical carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
CDK8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56723
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7651-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3473-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RNF185	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85169
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.972093
GSE242333_0_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RNOR-0526-SM-2TF4O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12962
Erythromycin_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0252681
OCI-M1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20004
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.686
GTEX-SSA3-0526-SM-32QPL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870033
BC-54-ON71_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.418375
GTEX-O5YT-1326-SM-3MJGR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18241
Leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.893
GTEX-T5JW-1826-SM-3GAE1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.26552
GTEX-TSE9-0011-R9A-SM-3DB7Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22434
u251mg	HPA Cell Line Gene Expression Profiles	1.0	1.18157
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JK-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ASS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77886
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.97917
CRCGN017_MCF10A.TP53.M_24H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.64777
UF-14-LK87_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.563783
CRCGN013_HEPG2_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.54256
MYRFL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.0212
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
API5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57187
E2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.787
ED-81-ZH14_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.22322
GTEX-XMD1-0008-SM-4AT41	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40973
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	1.0	2.243
AA-45-AA67_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.242903
GTEX-X585-3026-SM-46MWF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.951495
RRAGC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.89341
etoposide_homo sapiens_gpl10558_gse33990	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YA-85-VH07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.32549
Mitochondrial respiratory chain complex III	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.816
pyrroline-5-carboxylate reductase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.802
carbohydrate catabolic process	GO Biological Process Annotations 2025	1.0	null
HARA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:H06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.75364
TCAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.78903
IZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.978036
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.57013
CRCGN008_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.1424
GABPA	ENCODE Transcription Factor Targets	1.0	null
GTEX-P44H-0426-SM-2XCEZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.50115
succinate-CoA ligase complex (GDP-forming)	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.508
NR1D1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.0652
GSE135350_2_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AA-22-UI44_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.481148
CRCGN009_HEPG2_24H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.01109
GSE173232_2_v_3_sf3b1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-N7MS-0011-R6a-SM-2HMJ4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.920091
CRCGN016_MCF10A.TP53.M_24H:M01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20745
CP in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1544
Allantoin_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0292053
GTEX-NPJ8-0011-R10A-SM-2YUMO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908058
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RE-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE227592_5_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE249544,GSE249637_6_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
3554_GSPT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.550657
KG-1A cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.881
Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OQ-01A-32R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16609
BB-79-AG41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.678813
Bendamustine_A-172	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00581447
HT-55	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.98049
cardiovascular system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
diencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
pineal gland	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.953075
GSE227592_9_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
MARK4	Kinase Library Serine Threonine Kinome Atlas	1.0	null
Lung adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.572
TMC6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.2984
GSE171837_0_v_3_bortezomib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-73-4670-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE261563_0_v_1_atrx_human	RummaGEO Gene Perturbation Signatures	1.0	null
CSDE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.95695
GSE219195_0_v_2_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PP-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Naproxen_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0311215
SGTB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.65792
Musculoskeletal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.505
GSE205976,GSE205978_2_v_5_cep83_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Endocervical adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.027
NEK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.20933
Adrenocortical carcinoma_ACC_TCGA-OR-A5JP-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83596
CRCGN014_HEPG2_24H:N12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.51945
MDA-MB-175-VII	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.827223
CKM complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.46
GSE185519_1_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Afatinib_PANC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0190455
G121	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14681
COLO 794	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.855521
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-3.4692
CFAP36	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.3485
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.519538
GSE206516,GSE206518_6_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7475_RPL5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.03482
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09737
GF-32-FY02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.229346
CRCGN008_HEPG2_24H:O17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45445
DC-23-UM36_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.414632
CRCGN017_MCF10A.WT.HP_24H:H07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7525
MYH10	Pathway Commons Protein-Protein Interactions	1.0	null
Erythromycin_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0428884
GSE193258,GSE193259_9_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATP5MC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.56087
Cardiomyopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.008
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.36683
GSE154577_2_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-SUCS-1426-SM-4DM5W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44849
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
BAIAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.18498
TES	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16584
extracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
LUDLU1	CCLE Cell Line Gene CNV Profiles	1.0	1.49833
Erythromycin_LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0143293
PROKR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11978
GSE158834_1_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.09295
HNRNPAB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE230174_0_v_1_dagla_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Type 2 diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.205
CRCGN015_MCF10A_48H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.45011
medial superior olive	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10646
CRCGN008_HEPG2_24H:P03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.9004
lat1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.963
EE-03-SG02_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.441771
Urinary system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.746
GTEX-P78B-0426-SM-2I5F5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902505
CRCGN014_HEPG2_24H:B14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46432
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88055
C4orf48	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.63872
GSE194396,GSE194429_1_v_0_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KYM-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.88848
GTEX-QXCU-1726-SM-2TC6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66394
GSE182680,GSE182683_7_v_9_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PITX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0032
CRCGN015_MCF10A.WT.HP_24H:I16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.35156
single-organism metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE168602,GSE168604_2_v_6_selumetinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DFFB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.03951
GTEX-PW2O-0826-SM-48TC5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0008
NSC-34 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.519
Idarubicin (hydrochloride)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0316657
GTEX-U3ZN-2326-SM-3DB7W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18641
2548_EIF3D_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.05032
Idarubicin (hydrochloride)_A-427	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0215328
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2285
GSE245407,GSE245412_0_v_1_smurf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.99903
PTPN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64978
GSE244233_1_v_0_quercetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-X638-0426-SM-47JY2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851298
RPL28	Pathway Commons Protein-Protein Interactions	1.0	null
muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.290654
cell part	GO Cellular Component Annotations 2015	1.0	null
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Epithalamus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.316
Pentoxifylline_CFPAC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00607716
CRCGN009_HEPG2_24H:L08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-8.4718
SPIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.72402
C2orf69	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.97829
GSE176305_0_v_3_rotenone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
AF-41-QY60_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.851752
OE-31-YC41_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.472079
PIGT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25234
CRCGN017_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7264
SLTM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10093
2030_DARS_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.38245
CRCGN011_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.17625
avian pallium	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Secretory granule	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866509
Thymus	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.20977
Uterine disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.333
SNU601	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32402
PABPC1	Pathway Commons Protein-Protein Interactions	1.0	null
CTCF_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
positive regulation of sperm motility	GO Biological Process Annotations 2015	1.0	null
7753_SEC61G_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.10236
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Leiomyosarcoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
Aa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.501
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BA-84-TD72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292787
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19007
skbr3	HPA Cell Line Gene Expression Profiles	-1.0	-0.983624
Pheochromocytoma and Paraganglioma_PCPG_TCGA-TT-A6YP-01A-21R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF3	ENCODE Transcription Factor Targets	1.0	null
CRCGN013_HEPG2_24H:B13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.92334
GSE225982_2_v_0_ezetimibe_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KHOS-240S cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.595
GSE102505_4_v_2_tunicamycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of sperm motility	GO Biological Process Annotations 2015	1.0	null
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1795
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.42078
TFAP4::ETV1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.4436
ETV2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32814
epididymis	HPA Tissue Protein Expression Profiles	1.0	0.928216
Dihydrolipoyl dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.28
3986_HSPE1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.668459
GTEX-RWSA-0626-SM-2XCBD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3255
Viral infectious disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
oculomotor nuclear complex, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.930782
GTEX-OIZH-1626-SM-2HMKI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.82872
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25399
PHC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94116
RPS18	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:M04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26089
hsa-miR-4302	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GTEX-PSDG-0008-SM-48TE5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.42838
CRCGN016_MCF10A.TP53.M_24H:D19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.66848
DB-21-FY75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.360558
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78453
TPGS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13199
1386_CDC123_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.03489
Epirubicin (hydrochloride)_Panc 03.27	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0171428
Myopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
PABPC4	Pathway Commons Protein-Protein Interactions	1.0	null
IRS4	Pathway Commons Protein-Protein Interactions	1.0	null
Phosphopyruvate hydratase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.863
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.277197
CRCGN009_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.36199
FASTKD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76406
CRCGN012_HEPG2_24H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.91557
GSE149035_1_v_5_hepacam_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.05942
Brain Lower Grade Glioma_LGG_TCGA-DB-5281-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.83985
NALF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.66503
GSE105173,GSE105175_1_v_0_dhx36_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NR1H3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.65388
CRCGN016_MCF10A.WT.HP_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4127
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.856991
SOX13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.817
CRCGN008_HEPG2_24H:H24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-10.0
CRCGN012_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.35442
EMC9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59131
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8518-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN008_HEPG2_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7933
WB-54-WD35_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205525
molecular_function	GO Molecular Function Annotations 2015	1.0	null
CRCGN009_HEPG2_24H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-7.36207
CRCGN016_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.36665
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.311
CRCGN011_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4519
NFYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9294
ZNF559	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.51874
TCFL5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4414
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8292
Oxoglutarate dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.117
GTEX-V1D1-0008-SM-4JBIJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24963
hsa-miR-548j	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE211128_4_v_1_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:N10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47424
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75459
GTEX-NPJ7-0008-SM-4E3JS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15692
Autonomic nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.154
ACTL10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.49671
Autoimmune disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.242
Leukemia cell	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.893
ERCC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67397
CAL851	CCLE Cell Line Gene CNV Profiles	1.0	1.49544
male reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.479702
GSE176305_0_v_1_rotenone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.33338
NS-0 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.568
Zbtb2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.8685
GSE201657_0_v_1_ash2l_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.1138
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
MIEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.40394
CRCGN016_MCF10A.WT.HP_24H:D05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.18385
Palmitoyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.045
Tertiary granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.54
CYB5R2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42631
SDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36863
GTEX-O5YW-0008-SM-4E3IE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01908
ADCY6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52906
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8694
LC1SQSF	CCLE Cell Line Gene CNV Profiles	1.0	1.67658
GSE149901_3_v_0_anlotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
kinase binding	GO Molecular Function Annotations 2025	1.0	null
BT20	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.859684
Nr5a1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	30.1335
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.86075
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.15991
PMC5335506__F2a	PFOCR Pathway Figure Associations 2023	1.0	null
BNC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.93901
prefrontal cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-N7MS-0011-R10A-SM-2HMJK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14669
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.616
CRCGN014_HEPG2_24H:H21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.71305
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29C-06A-21R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6868-01B-12R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW579	DepMap CRISPR Gene Dependency	1.0	5.87916
GSE218378_1_v_0_pbx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:B21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.70195
Ecsit-NDUFAF1 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.52
GSE158834_10_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
QE-48-NG07_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.24679
IX, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.0581
GSE169356_0_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
T-lymphocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.551
GAS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77188
hsa-miR-548n	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12314
subthalamic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.84741
MLXIPL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9741
PABPC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93199
Cell type benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.075
DA-35-DU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.30688
EFR3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93849
GSE154577_7_v_10_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.9494
GTEX-XOT4-0526-SM-4B66O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37727
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.589225
ELF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6558
CRCGN015_MCF10A.WT.HP_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.3579
CRCGN015_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.77123
GSE135352_0_v_4_napabucasin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:J19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59308
PMC5879948-97320630014068.nxml--TP53_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
APRT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.59319
A-172 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.558
CRCGN014_HEPG2_24H:H09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8724
ACSBG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.79752
vascular bundle	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
MALSU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77489
Cytoplasmic side of plasma membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.037
Idarubicin (hydrochloride)_HepG2/C3A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0165096
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09482
ZBTB33	ENCODE Transcription Factor Targets	1.0	null
Autosomal genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.122
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.897854
single-organism process	GO Biological Process Annotations 2015	1.0	null
GSE143462_0_v_1_omipalisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE154197_1_v_2_ints13_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201309_4_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BAK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27732
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05678
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7745
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46001
CRCGN009_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.89784
UNC13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.23932
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.58529
Sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.159
AA-32-DP01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.20724
CRCGN014_HEPG2_24H:H18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.52243
ID-00-IC14_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.956986
FOXI2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.41143
4004_IARS_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.25509
OVCA 429	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00785
CRCGN017_MCF10A.TP53.M_24H:K10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.24115
4271_KANSL2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.14201
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.930942
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PANC0403	CCLE Cell Line Gene CNV Profiles	-1.0	-1.37532
Spleen	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.896739
Epithelioma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-QEG5-1126-SM-33HC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.854019
RREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	317.364
YA-78-MS95_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.584328
WDR76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.56202
MNT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6555
GSE182680,GSE182683_10_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.98025
CCNI	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58838
GTEX-N7MT-0326-SM-48TDP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851501
Brain Lower Grade Glioma_LGG_TCGA-E1-A7Z3-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02458
GTEX-P4QS-0626-SM-3NMD1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03792
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Plasmacytoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.553
6858_PSMC2_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.2465
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2J7-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pineal gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.316
KLF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	129.256
RNF114	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11493
hsa-miR-4762-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
GSE154253_1_v_0_tnfaip8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
9339_TSEN54_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.0546
GTEX-OIZI-0626-SM-2XCEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58942
GSE123689_1_v_0_cbx8_human	RummaGEO Gene Perturbation Signatures	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
EIF5A2	Pathway Commons Protein-Protein Interactions	1.0	null
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN015_MCF10A.TP53.M_24H:C04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2491
6870_PSMD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.646896
Epirubicin (hydrochloride)_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0179979
CRCGN014_HEPG2_3H:M21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.12195
HUWE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.06203
GTEX-V1D1-0526-SM-4JBGW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845706
hsa-miR-4659a-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
CC-04-WK34_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221026
TMEM140	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27842
PRRX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.246
GTEX-WFJO-0826-SM-4LVM5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.909341
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
secretory granule lumen	GO Cellular Component Annotations 2025	1.0	null
GSE169205_3_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Cranial ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.176
Bone	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.757
hsa-miR-32	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
CRCGN014_HEPG2_24H:A03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.60333
CRCGN012_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.58733
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24767
organelle	GO Cellular Component Annotations 2015	1.0	null
GTEX-Q734-2026-SM-3GADA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4124
phenylalanine-tRNA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.564
C32	COSMIC Cell Line Gene Mutation Profiles	1.0	null
respiratory epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CRCGN017_MCF10A.WT.HP_24H:E14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4882
carbohydrate catabolic process	GO Biological Process Annotations 2015	1.0	null
CB-16-SY72_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.490984
SNAI2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5992
CPCN	CCLE Cell Line Gene CNV Profiles	1.0	1.98021
Disease of mental health	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.108
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	91.1314
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A73C-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.88607
spermatid	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.816904
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:N15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.00413
BE-79-QU25_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.728549
GTEX-RWSA-0008-SM-47JYX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43239
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
2251_DMAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.569726
EF-43-OP88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.385503
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4151-01A-01R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Tricarboxylic acid cycle enzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.732
GSE148269,GSE148273_0_v_1_arid4b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MZ in dorsomedial extrastriate cortex (V2)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.921967
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04022
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-QQ-A8VF-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC1937	DepMap CRISPR Gene Dependency	1.0	2.1914
Sox11	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.5552
ANP32D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.11712
LS1034	DepMap CRISPR Gene Dependency	1.0	3.682
Epirubicin (hydrochloride)_MIA PaCa-2	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0255901
PFKL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27299
hsa-miR-4659b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855064
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28021
IA-LM	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ZNF528	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.9594
AA-23-FM46_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.276101
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE221327_4_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	1.0	null
TVP23B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.00833
EFO21	DepMap CRISPR Gene Dependency	1.0	2.21433
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.14904
retina	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2421
CRCGN013_HEPG2_24H:K05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4808
GSE190555,GSE190557_2_v_0_chd4_human	RummaGEO Gene Perturbation Signatures	1.0	null
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3762
SNX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.11132
GSE249544,GSE249637_6_v_5_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHSE-3026-SM-3P5ZH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846643
BA-95-YU85_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.429481
GTEX-PWO3-0011-R8A-SM-2I5GD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24673
GSE169152_5_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178340_1_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38476
JD-58-MV19_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218482
GSE190384,GSE190386_6_v_8_fulvestrant_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GJA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01297
Non-Obstructive Azoospermia	DisGeNET Gene-Disease Associations	1.0	null
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8589
ZNF549	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.6992
CRCGN014_HEPG2_24H:M14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69668
hsa-miR-615-3p	MiRTarBase microRNA Targets	1.0	null
GSE147283_1_v_3_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221793
GSE205976,GSE205978_1_v_4_cep83_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE221577_4_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
embryonic lethality, complete penetrance	MGI Mouse Phenotype Associations 2023	1.0	null
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.231482
GSE215086_8_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-POYW-0826-SM-2XCEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01627
positive regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
Acute lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.893
TNFAIP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40982
CFL1	Pathway Commons Protein-Protein Interactions	1.0	null
2537_EIF2B3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.530574
Menkes disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.311
LB-04-KP05_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.254811
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74499
hsa-miR-767-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
7657_SARS_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.578559
GTEX-OHPN-0011-R3A-SM-2I5FC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884482
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
pedunculo(pontine) tegmental  nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.10651
GSE221577_2_v_5_pik3r1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Nfatc1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4741
GSE236486_1_v_0_arnt_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-10.0
Lung adenocarcinoma_LUAD_TCGA-50-6594-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE154577_7_v_12_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE121866_0_v_2_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE123638,GSE123639_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BD-96-HO33_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251802
MAFK	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.8183
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.90355
ILF2	Pathway Commons Protein-Protein Interactions	1.0	null
Superior temporal gyrus	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.646
CRCGN017_MCF10A.WT.HP_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.8938
HCC95	CCLE Cell Line Gene CNV Profiles	1.0	1.51225
RA-42-CM42_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.355975
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972991
GSE190316,GSE190324_10_v_9_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
SEL1L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.11768
IFRD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.07319
isomerase activity	GO Molecular Function Annotations 2015	1.0	null
GSE128730_7_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JHOS2	CCLE Cell Line Gene CNV Profiles	1.0	1.40336
SNX5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.34185
Prefoldin complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.724
TRIM68	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10868
NC-52-AG88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27533
TD-69-UA90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.225291
ZR-75-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.869402
PB-09-OE00_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.689323
CRCGN017_MCF10A.TP53.M_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.9413
Lung adenocarcinoma_LUAD_TCGA-50-5044-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CLPTM1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30391
ventral tegmental area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.47861
UACC-812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.20554
GSE119978,GSE180930_0_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CCDC93	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.72687
VIIIA, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.99949
IC-05-AW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.487045
CALU	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.61361
BF-89-QD24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.338293
Naproxen_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0261611
CRCGN015_MCF10A.TP53.M_24H:C07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.04415
RCC-10 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.616
GSE181003_3_v_2_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-6743-01A-11R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8310438__F1	PFOCR Pathway Figure Associations 2024	1.0	null
Afatinib_HepG2/C3A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.016102
CASP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13087
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-0.918488
Lung adenocarcinoma_LUAD_TCGA-38-4629-01A-02R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.62731
PAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9065
acrosomal vesicle	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.656033
TCFL5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68842
K562_UNC1999_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172891
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.10019
BD-49-MD69_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.623482
XYLT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84754
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2ES-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE197850_4_v_3_glucagon_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN012_HEPG2_24H:D09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.71551
AsPC-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.873
CRCGN016_MCF10A.WT.HP_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47145
6868_PSMD14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.940166
EIF5A	Pathway Commons Protein-Protein Interactions	1.0	null
5889_NUP160_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.09207
CRCGN008_HEPG2_24H:K12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3266
GTEX-S7SF-2026-SM-3K2AS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43207
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_11_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Secretory vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	4.0
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.28872
RNA polymerase II termination complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.641
PMC10318747-12864_2023_9472_MOESM2_ESM.xlsx-OCI-AML3_30min_vs_Control-Unnamed_1_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Urinary bladder squamous cell carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.665
GSE138789_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0728
membrane-bounded vesicle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.663342
LCLC-97TM1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.8344
KCNMB4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.53731
569_ASB8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.799228
MCC13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XUJ4-2626-SM-4BOQ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.907032
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3641
GSE113005_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
spermatocyte	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.186632
BA-46-YF32_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.232102
KLK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.85734
DC-84-GJ21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28287
PMC7716236__F3	PFOCR Pathway Figure Associations 2023	1.0	null
Trunk	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.341
8229_SNRPD2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.664176
CRCGN016_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.01597
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A7JC-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Renal cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.566
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SEMA6A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07546
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.70399
TP53	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.1201
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.15819
hsa-miR-4648	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135350_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPM-0008-SM-4E3IP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.34087
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49089
CRCGN016_MCF10A.WT.HP_24H:G10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.92407
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.65665
GSC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.6878
GSE145171_0_v_1_prox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE150072,GSE169209_6_v_9_qser1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE249544,GSE249637_9_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Idarubicin (hydrochloride)_HCT15	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0166111
HSPB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.07905
MZ in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.978563
VA-06-DB75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.598557
Sarcoma_SARC_TCGA-DX-A3U8-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.731
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.23197
CRCGN014_HEPG2_3H:D07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.32116
GTEX-T6MO-0008-SM-4DM6T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.846111
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
CAPRIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.06399
GSE242083,GSE242098_3_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:A22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.80721
PIGW	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.83176
glycolytic process	GO Biological Process Annotations 2015	1.0	null
GTEX-XOTO-0526-SM-4B662	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.948534
GTEX-RM2N-1626-SM-2TF5N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08739
GTEX-WFON-2326-SM-3LK7M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13919
CRCGN012_HEPG2_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.22611
NR2F2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88045
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.530682
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.218092
GSE258991_5_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE190384,GSE190386_2_v_4_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3255	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.56449
SLC3A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.98643
ZSCAN16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2846
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-A8OV-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Intestinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.685
GSE128730_4_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN011_HEPG2_24H:A09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.1719
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.343
Erythromycin_A498	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0205736
HNRNPA1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WVLH-3026-SM-3MJG9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89195
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.0138
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870468
ATP5B	Pathway Commons Protein-Protein Interactions	1.0	null
4150_INTS5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.07131
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3012
CGTHW1	CCLE Cell Line Gene CNV Profiles	1.0	2.20946
RNF146	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.71855
FC-85-OX77_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.322
7657_SARS_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.11108
nucleus of diagonal band	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.03067
mononuclear phagocyte	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08438
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.30976
lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Mitochondrial respirasome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.54
Prostate adenocarcinoma_PRAD_TCGA-CH-5769-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
EML3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.57782
MZ in retrosplenial cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.964482
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.002
Lung squamous cell carcinoma_LUSC_TCGA-56-7822-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D9-01B-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FAM110A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.85716
CALU6	DepMap CRISPR Gene Dependency	1.0	2.79038
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TT-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
YBX1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-S4P3-1626-SM-3K2AZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37527
Naproxen_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0268829
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14042
ZNF282	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64137
CRCGN014_HEPG2_24H:M17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.005
GTEX-WVLH-0011-R10A-SM-3MJFM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2352
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
semen	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.169707
DB-01-BR68_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.321101
CRCGN013_HEPG2_24H:D08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.52488
bisphosphoglycerate phosphatase activity	GO Molecular Function Annotations 2015	1.0	null
GTEX-QEG4-0626-SM-2S1OY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95871
hsa-miR-4257	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.221401
cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
Lung squamous cell carcinoma_LUSC_TCGA-68-7756-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
FB-85-ND09_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256828
GSE206226_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN016_MCF10A.WT.HP_24H:P14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.25673
CRCGN012_HEPG2_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.91839
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5174-01A-01R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A655-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UPMD1	DepMap CRISPR Gene Dependency	1.0	2.58293
BA-59-EN38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.517698
Peripheral blood	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.893
hsa-miR-363	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
7515_RPS26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.525769
KGN	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RMUG-S	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05678
GSE176008_7_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.692
CRCGN014_HEPG2_3H:O20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20091
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HP1BP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33954
GSE178340_5_v_3_carfilzomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mononuclear cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
FE-10-KQ78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.779982
CRCGN011_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.8543
S0-EE-YRH3_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214241
CRCGN016_MCF10A.WT.HP_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.72125
CCER2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37313
GTEX-SUCS-0726-SM-4DM7J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.932777
GSE205730,GSE205731_2_v_0_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TIGD3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.15069
Bronchial epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.311
GSE154577_6_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pax7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.4092
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1002
hydrolase activity, acting on ester bonds	GO Molecular Function Annotations 2015	1.0	null
CRCGN009_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.29989
monocarboxylic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
Uterine corpus endometrial carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.048
GTEX-T6MN-0526-SM-32PMS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89169
Gonadal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.404
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-1.15587
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5CX-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0951
PF-59-CY33_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.581035
Pituitary gland tumor cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.716
IGR39	DepMap CRISPR Gene Dependency	1.0	2.89702
GSE239898,GSE239899_1_v_0_hiltonol_human	RummaGEO Drug Perturbation Signatures	1.0	null
phosphoglycerate mutase activity	GO Molecular Function Annotations 2015	1.0	null
CRCGN011_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1941
PC-1.0 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.5
PANC 05.04	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.910777
GTEX-PLZ4-0926-SM-2S1OI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56874
MYO1C	Pathway Commons Protein-Protein Interactions	1.0	null
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.69024
6-phosphofructokinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	2.056
single-organism catabolic process	GO Biological Process Annotations 2015	1.0	null
cytoplasmic vesicle lumen	GO Cellular Component Annotations 2025	1.0	null
Leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-WY7C-2526-SM-3NB2N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997136
canonical glycolysis	GO Biological Process Annotations 2025	1.0	null
7754_SEC62_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.658759
intracellular part	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041752
hsa-miR-4728-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BA-86-AL61_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.872706
GTEX-U4B1-1626-SM-3DB8N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42081
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850503
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
VANGL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.48183
GTEX-OOBJ-1626-SM-2I3F7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994854
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2956-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HC-74-HM63_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.547029
pyruvate metabolic process	GO Biological Process Annotations 2023	1.0	null
KIF13A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	4.91178
intramolecular transferase activity	GO Molecular Function Annotations 2015	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE154577_7_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
infertility	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.93207
Creatine kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.157
2858_FAM136A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.56117
Afatinib_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.020649
CRCGN016_MCF10A.TP53.M_24H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.493
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	1.0	2.23686
skeletal muscle	HPA Tissue Protein Expression Profiles	-1.0	-1.15587
GSE182680,GSE182683_5_v_3_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139016_3_v_1_disulfiram_human	RummaGEO Drug Perturbation Signatures	1.0	null
lateral dorsal nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.83928
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.753
BE-25-UR78_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.439349
Lung squamous cell carcinoma_LUSC_TCGA-66-2765-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3C15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.49622
PMC5821407__F4	PFOCR Pathway Figure Associations 2023	1.0	null
GTEX-OXRN-2426-SM-2I5EQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.988284
GSE181521_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
VAPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.32708
Mesothelioma_MESO_TCGA-LK-A4O0-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.67651
BB-84-DG64_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.212719
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05072
Stomach disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.425
NADH dehydrogenase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.766
GTEX-NPJ8-1626-SM-2HMIY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.895273
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.882
GTEX-NFK9-0008-SM-4E3JE	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83196
DMB	DeepCoverMOA Drug Mechanisms of Action	1.0	0.49
NADH metabolic process	GO Biological Process Annotations 2025	1.0	null
CRCGN013_HEPG2_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.75638
Cytosol	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	1.0	5.0
GSE222047_0_v_1_imidazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-P4QS-1626-SM-2S1NH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30619
nucleus coeruleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.16586
CRCGN016_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.23937
Tsu-Pr1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.557
Erythromycin_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0191069
Mitochondrial inner membrane peptidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.147
intramolecular transferase activity, phosphotransferases	GO Molecular Function Annotations 2023	1.0	null
2750_ETF1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.606841
GSE234514,GSE234516_1_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
doxorubicin_homo sapiens_gpl6947_gse25741	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.18325
GTEX-R55G-1026-SM-48FDI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.997461
Tca-8113 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.698
NFIC::TLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.75
GSE121866_0_v_3_six4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Basal ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.151
GSE258991_5_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.TP53.M_24H:L22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.23035
ANKLE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.81368
cardiac muscle	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Epirubicin (hydrochloride)_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0131415
GSE103068_0_v_1_volasertib_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-298	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6953-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BL3121 (SMEK1)	NURSA Protein Complexes	1.0	null
10720_ZSCAN26_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.503345
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell projection part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-A6NI-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.39225
CGTH-W-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
APOA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81109
Caudolateral nidopallium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.545
PITX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5675
Lhx3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	84.2
CRCGN014_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-9.76945
CRCGN016_MCF10A.TP53.M_24H:F10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.04878
TCF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4891
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28266
Erythromycin_hTERT-HPNE	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0315539
GSE139540_0_v_1_menadione_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE206516,GSE206518_1_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZDHHC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68156
PGAM1	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H2009	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.56449
GSE153867_6_v_8_olaparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2174
ERP29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22333
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	1.0	0.85723
FA-88-II68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.555256
CRCGN008_HEPG2_24H:I14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3266
GSE139455_0_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BF-26-MB27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327415
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.2375
CREB3L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.7607
mnng/hos	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.526
colonrectum_b	HPA Tissue Sample Gene Expression Profiles	1.0	0.930961
Pentoxifylline_AsPC-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00899518
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38364
GSE158834_10_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193541_0_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	1.0	null
adult stem cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.572872
PB-09-OE00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.04338
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RASGEF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.98537
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KLF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.10532
NR2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.6079
RAP2C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.8752
H3K36me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN010_HEPG2_24H:O08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.55529
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23207
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.1156
CRCGN014_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.01853
CRCGN014_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.26568
Vitamin K4_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00868461
CRCGN012_HEPG2_24H:G13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.3652
Skin cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.01
MFM-223 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.56
GA-59-RW04_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.226124
CRCGN016_MCF10A.TP53.M_24H:O13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.01753
LPIN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.71251
hsa-miR-423-5p	MiRTarBase microRNA Targets	1.0	null
MMP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.76019
CRCGN014_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.39673
CRCGN016_MCF10A.WT.HP_24H:F05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.00773
RAB39B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86868
CRCGN015_HEPG2_48H:A13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.80753
16597596-TableS1-6	GeneSigDB Published Gene Signatures	1.0	null
hsa-miR-410	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE182680,GSE182683_5_v_13_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.74856
extracellular vesicular exosome	GO Cellular Component Annotations 2015	1.0	null
hsa-miR-559	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
CRCGN015_HEPG2_48H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15914
Uropod	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.552
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.500434
CRCGN017_MCF10A.WT.HP_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.401
NCIH1581	DepMap CRISPR Gene Dependency	1.0	2.45009
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Genetic Diseases, X-Linked	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE118077_7_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
hematopoietic cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intracellular organelle lumen	GO Cellular Component Annotations 2025	1.0	null
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.525
AB-09-EA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.509637
ABLIM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.01197
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.64102
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17X-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184399_0_v_2_cnot1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68006
Epirubicin (hydrochloride)_SW1417	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0226504
CRCGN011_HEPG2_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7462
CRCGN014_HEPG2_24H:P07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0914
Idarubicin (hydrochloride)_NCI-H2347	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0309553
Interstitial cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE168587,GSE168752_3_v_1_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Infertility, Male	HuGE Navigator Gene-Phenotype Associations	1.0	null
GSE160817_3_v_1_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN015_HEPG2_48H:D17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.2008
Idarubicin (hydrochloride)_SW 900	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0196522
SF3B6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32694
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RV-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12271601-mmc2.xlsx-OUT_cells_03-Gene_Symbol_TCF23	Rummagene Transcription Factor Associations 2026	1.0	null
Parietal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.98
Lung adenocarcinoma_LUAD_TCGA-05-4382-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-10.0
GSE161800_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN013_HEPG2_24H:N13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.59567
ARHGAP11A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.78962
Lymphoblastic leukemia cell line	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.893
b-lymphoblastoid cell	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LAMA-84 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.715
CENPT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17561
STK11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.92044
CRCGN010_HEPG2_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.96752
CRCGN015_MCF10A.TP53.M_24H:O07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7423
CRCGN010_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.1129
GSE158834_10_v_3_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXN3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.88783
DCUN1D5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.82637
GSE116810_2_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE193258,GSE193259_5_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Secretory granule lumen	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.715
hsa-miR-4279	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
CRCGN013_HEPG2_24H:I13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.97523
RCOR1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73592
GSE239844_1_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SN8G-0326-SM-32PLG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21301
APOBEC3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51363
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00221
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-2.08697
Oral cavity cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.169
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A688-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_9_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-90-7769-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH2009	CCLE Cell Line Gene CNV Profiles	-1.0	-1.75629
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Sperm principal piece	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.077
Ursodiol	DeepCoverMOA Drug Mechanisms of Action	1.0	0.43
GSE140936,GSE140938_2_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.834
secretory granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.293267
FAM111A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.90827
GSE153871_4_v_3_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GC-04-UF36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.689215
B-lymphoblast	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.316
EA-32-CY22_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215722
PCBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.39696
GSE115763_3_v_1_klf6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FB-24-UT80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.354817
HRH2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.37959
GTEX-OXRL-0626-SM-3NM9C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833816
TBX20	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.12984
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.1639
EOMES	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1162
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.63707
hsa-miR-1914	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
Sarcoma_SARC_TCGA-X6-A8C4-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128730_4_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DUXB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93697
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052068
CRCGN012_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.46444
RBM46	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64875
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-RQ-A6JB-01A-11R-A31O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACSM4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.13837
single-organism cellular process	GO Biological Process Annotations 2015	1.0	null
COQ4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.76364
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-0.745453
CRCGN017_MCF10A.WT.HP_24H:H08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.7186
GSE143499_0_v_1_gata6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN009_HEPG2_24H:A18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07783
CRCGN014_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.8818
C1orf216	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.04149
Fatty acid synthase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.233
MZ in dysgranular insular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.994142
positive regulation of flagellated sperm motility	GO Biological Process Annotations 2023	1.0	null
TUBB	Pathway Commons Protein-Protein Interactions	1.0	null
GSE201309_4_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22356
GTEX-U3ZG-0326-SM-47JXN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33256
GSE186647,GSE217288_1_v_7_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AD-86-ES28_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.7064
endocrine gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056682
CRCGN017_MCF10A.WT.HP_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.91105
GTEX-WFG7-1126-SM-4LMK3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03379
EHBP1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.71285
Rfx6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.643
CRCGN015_MCF10A.TP53.M_24H:B07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.69525
Prostate adenocarcinoma_PRAD_TCGA-M7-A725-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3-5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.89653
Brain cell line	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Lung adenocarcinoma_LUAD_TCGA-50-6595-01A-12R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135030_8_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174498,GSE174500_3_v_4_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.650508
CRCGN017_MCF10A.WT.HP_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0656
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35207
Cardiovascular system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.419
Epirubicin (hydrochloride)_A549	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0258643
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84973
NIBAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21541
PK-59	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05678
RPL13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.19015
GSE140965_2_v_3_mybpc3_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.13114
9473_U2AF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-1.04822
Mesophyll	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.823
CCNB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.67065
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12261
CRCGN016_MCF10A.WT.HP_24H:A20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.51115
GSE125403_3_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Electron transfer flavoprotein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.736
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.86204
CRCGN009_HEPG2_24H:H14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.91564
COR-L303	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DD-65-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.9644
11152_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.542796
MXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.4469
dephosphorylation	GO Biological Process Annotations 2015	1.0	null
HNRNPC	Pathway Commons Protein-Protein Interactions	1.0	null
Thyroid	GTEx Tissue Gene Expression Profiles 2023	1.0	6.48334
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PWWP2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7444
GTEX-S7SF-0926-SM-4AD4M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950043
CRCGN009_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29982
GSE229973_3_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
anterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.5878
KMT5B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.38019
GSE146982_3_v_2_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.31933
BD-25-SA37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222825
HIC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2976
RAB5IF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.09202
Kidney Chromophobe_KICH_TCGA-KM-8476-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
epithelium	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.237908
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.856438
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61E-01A-22R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE165548_2_v_5_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Erythromycin_HS-578T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00994855
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3309
7538_RPS8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.675435
limbic system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4147_INTS2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.537034
GSE160817_2_v_9_slamf6_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN014_HEPG2_3H:A16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.19567
COV362	CCLE Cell Line Gene CNV Profiles	1.0	1.3748
TENM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.21929
CRCGN016_MCF10A.TP53.M_24H:E20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.02861
GSE154577_2_v_9_plagl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126463_0_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE60217_1_v_8_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.291
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.055
IB-96-PK68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205839
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7411-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BC-09-XQ45_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.260347
Brain disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.356
BA-46-AB67_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.265948
medial geniculate nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.900934
regulation of cell motility	GO Biological Process Annotations 2015	1.0	null
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
basal ganglion	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
GTEX-XUW1-0826-SM-4BOP6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45327
Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A4EM-01A-11R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.64155
GTEX-NL3G-0008-SM-4E3JX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4176
GTEX-POYW-1226-SM-2XCEP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944276
brain	HPA Tissue Gene Expression Profiles	1.0	0.944189
GSE155567_3_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Erythromycin_NCI-H2030	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00970535
Skin - Sun Exposed (Lower leg)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.774605
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-A8YI-01A-21R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.877
INPP5K	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13974
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1037
POU2F2	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-4326	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
MZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.0601
succinate-CoA ligase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.937
skeletalmuscle_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.93547
Myxosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.07
CRCGN016_MCF10A.TP53.M_24H:H05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.19885
GTEX-NPJ7-0011-R8a-SM-2I3G2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.963457
GSE211262,GSE211263_3_v_1_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QEG4-0426-SM-33HC3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19616
MRPL16	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.6804
COL18A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27437
MRPL17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.6672
BE-79-QU25_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.82622
SAMD8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51969
T-cell chronic lymphocytic leukemia cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
LRCH4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.26642
Urinary system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.671
PEX26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.5127
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	355.783
QE-79-XO29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.255534
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A4S6-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRSK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.35871
GSE123943_4_v_0_sox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE158834_1_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular_component	COMPARTMENTS Text-mining Protein Localization Evidence Scores	1.0	0.041261
GSE239844_7_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LN235	DepMap CRISPR Gene Dependency	1.0	2.38969
Nerve	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.077
Idarubicin (hydrochloride)_C-33 A	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0351193
18818702-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
AQP11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.68371
KDM1B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-4.10054
Talc_RKO	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0255198
6845_PSMA5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.663271
5468_NARS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	-1.0	-0.50308
posterior hypothalamic area, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.2941
GSE135400_1_v_0_kdm1b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Olfactory bulb	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.481
Hematopoietic system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE138633_2_v_0_bag3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Embryonic brain	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.76
GTEX-UTHO-0011-R2A-SM-3GIKC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.81815
Brain Lower Grade Glioma_LGG_TCGA-S9-A6WL-01A-21R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.882629
GSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6869
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
rostral group of intralaminar nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.95781
AD-16-HL96_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.946277
TUBA4A	Pathway Commons Protein-Protein Interactions	1.0	null
ESO26	COSMIC Cell Line Gene Mutation Profiles	1.0	null
non-Hodgkin lymphoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.065