association dataset threshold value standardized value H3K4me3_astrocyte of the cerebellum_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4756-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IZ in posteroinferior (ventral) parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.974835 REST_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GF-35-IT27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.210258 GSE131887_5_v_2_doxycycline_mouse RummaGEO Drug Perturbation Signatures -1.0 null BA-15-VE07_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.509296 Digestive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-PLZ6-0226-SM-3P61I GTEx Tissue Sample Gene Expression Profiles 1.0 0.987385 GSE146982_4_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K27ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE151494_8_v_3_nrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null shell of SCH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21062 Duchenne muscular dystrophy (DMD)_Muscle - Striated (Skeletal) (MMHCC)_GSE1025 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.43609 PF-382 COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC1806 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.937142 GSE186810,GSE186813_7_v_5_furin_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE226249_5_v_7_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_B cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SARS-BatSRBD_0Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.2077 SW 1417 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.882347 SP3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 91.3948 A549_Aurora A Inhibitor I_1µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0146665 KASUMI-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.59311 IRX5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.32297 TCF7L2_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWS6-1126-SM-47JXC GTEx Tissue Sample Gene Expression Profiles -1.0 -2.12756 episupraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.74964 ARID3A ENCODE Transcription Factor Targets 1.0 null PMC12006367-41537_2025_609_MOESM4_ESM.pdf-11-MYPOP_MYPOP Rummagene Transcription Factor Associations 2026 1.0 null Folium-tuber vermis (VII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.66604 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_cardiac mesoderm_hg19_8 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100454_FWM_no dementia_TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.05045 GSE195663_7_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WK11-2526-SM-3NM9Y GTEx Tissue Sample Gene Expression Profiles -1.0 -1.83368 496100637_FWM_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.39102 principal sensory nucleus of trigeminal nerve, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.29286 Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-CS-4944-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_16910_KO_Ezh2_SRP314053 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.95643 Purkinje cell layer of CbVCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40708 CD19+_BCells(neg._sel.) BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.15661 Liver hepatocellular carcinoma_LIHC_TCGA-BC-A69I-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE149355_0_v_1_esrp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null zinc ion binding GO Molecular Function Annotations 2015 1.0 null ZNF282 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.1092 MAFF ENCODE Transcription Factor Targets 1.0 null lung TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 SOX2 ChEA Transcription Factor Targets 1.0 null Sarcoma_SARC_TCGA-FX-A48G-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_NANOG_targets_Boyer_NANOG Rummagene Transcription Factor Associations 2026 1.0 null GSE112761,GSE112767_1_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null KLF17 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 72.0412 Histone acetyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.572 posterior (caudal) superior temporal cortex (area 22c)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07564 GSE148066,GSE157787_2_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null BHLHE40_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_HepG2_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nasopharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 DV90_LUNG CCLE Cell Line Proteomics 1.0 6.05333 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_2_GSC Rummagene Transcription Factor Associations 2026 1.0 null Nodulus (X), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48703 DMS153 CCLE Cell Line Gene Expression Profiles -1.0 -1.923 GTEX-PLZ5-0326-SM-3P614 GTEx Tissue Sample Gene Expression Profiles 1.0 1.79377 NRF1 JASPAR Predicted Transcription Factor Targets 1.0 null posterolateral cortical amygdaloid area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07782 POLR2A_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_3_TurboID_1hr_ERM_proteome-Gene_Name_ETV5 Rummagene Transcription Factor Associations 2026 1.0 null temporal neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.968777 Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9IC-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 7505_RPS16_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.514247 ATF3 ENCODE Transcription Factor Targets 1.0 null H3K36me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Entorhinal area, medial part, ventral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34609 alimentary canal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 non-Hodgkin lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.308 NCI-H1299 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.017 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.92647 r1 roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.54209 SIN3A ENCODE Transcription Factor Targets 1.0 null GSE236280_0_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-WFG8-0006-SM-3GIKS GTEx Tissue Sample Gene Expression Profiles 1.0 0.969149 Tuberomammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02671 POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE162892_4_v_2_sox9_human RummaGEO Gene Perturbation Signatures -1.0 null LNCAP-CLONE-FGC COSMIC Cell Line Gene Mutation Profiles 1.0 null ZBTB33_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rbm15_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.003807 H3K4me3_cardiac mesoderm_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BCL3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletal muscle HPA Tissue Gene Expression Profiles -1.0 -1.27138 Cortical amygdalar area, posterior part, lateral zone, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0737 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.05461 orbital frontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.39696 MFE319_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 5.6528 OCIAML2 DepMap CRISPR Gene Dependency 1.0 2.99621 PL45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.04205 GSE115542_2_v_3_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5116 GSE226249_2_v_8_pirfenidone_human RummaGEO Drug Perturbation Signatures -1.0 null EBF1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-64-1677-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NANOG-21062744-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null POLR2A_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CACO-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.8502 GSE142210_9_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null TNKS_INHIBITION_GDS5029_281_human_SW480 KRAS-mutant colorectal cancer cell line - 16hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null COLO678 CCLE Cell Line Gene CNV Profiles -1.0 -1.58723 GSE142210_3_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null r10 part of basomedial reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29537 H3K4me3_fibroblast of pulmonary artery_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WH7G-0826-SM-4LVMR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.76473 Arm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.001 H3K4me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BCL3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F4-21247883-LYMPHOBLASTOID-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null COLO-320-HSR Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.89683 GSE117730,GSE117732_0_v_2_apobec2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H4K20me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null outer SZ in ventromedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.903139 regulation of autophagosome assembly GO Biological Process Annotations 2025 1.0 null regulation of autophagosome maturation GO Biological Process Annotations 2025 1.0 null FC-20-EQ58_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.71907 layer 1 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19921 RCOR1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF343 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 53.6747 AKT1_activemutant_216_GSE9484 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.87361 SOX9-26525672-CHIP-SEQ-HEART-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE242199_6_v_11_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null Bach1 MotifMap Predicted Transcription Factor Targets 1.0 null YY1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Medullary reticular nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22293 GABPA_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE162739_6_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE235701,GSE261434_2_v_3_enasidenib_human RummaGEO Drug Perturbation Signatures 1.0 null BPH-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.65386 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.91316 Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A63U-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD4_Memory_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.35176 Serum Albumin Measurement DisGeNET Gene-Phenotype Associations 1.0 null GTEX-UPIC-0005-SM-3GACV GTEx Tissue Sample Gene Expression Profiles 1.0 0.904657 H3K36me3_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KURAMOCHI CCLE Cell Line Gene Expression Profiles 1.0 1.42134 stratum pyramidale of rostral CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1277 GTEX-OXRP-0926-SM-48TC1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.937921 SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.9561 lateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.14572 GTEX-OXRO-0011-R2A-SM-3NB1W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.26815 RMUG-S Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.86886 MD-84-YS12_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.52582 retina BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.10117 PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null POU5F1-18347094-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-P4QS-1326-SM-3NMCD GTEx Tissue Sample Gene Expression Profiles 1.0 0.999532 1716_CNOT1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.71862 HMGCL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31118 H3K4me3_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE184884_2_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE192663_3_v_5_acly_mouse RummaGEO Gene Perturbation Signatures -1.0 null GC-04-UF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.218341 Oviduct TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 YD-49-HM53_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.68031 GTEX-S4Q7-0008-SM-3NM8A GTEx Tissue Sample Gene Expression Profiles 1.0 0.847592 Brain - Substantia nigra GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.32122 GTEX-WL46-0526-SM-3LK7W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03764 IRF1 ENCODE Transcription Factor Targets 1.0 null KA-29-AB08_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.234595 GSE142210_3_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.59239 POLR2A_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE186660_2_v_1_nicotine_mouse RummaGEO Drug Perturbation Signatures -1.0 null KURAMOCHI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.2583 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AA-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bone marrow cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.371 GSE125014_6_v_2_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null KRIT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.06462 H3K4me3_MCF-7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null YD-49-HM53_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.97631 ATF3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null substantia nigra reticulata, m1 part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0741 JUND_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of r6BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28769 ARID3A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null icSARA deltaORF6_48Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.18894 EP300_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hematopoietic cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.060531 SPI1-22790984-ERYTHROLEUKEMIA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE217776,GSE217829_2_v_6_sgf29_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-3074-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.568687 DB-21-FY75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.53116 RMGI CCLE Cell Line Gene CNV Profiles -1.0 -1.36028 ETS1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SIU8-0426-SM-4BRUE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12593 GSE247764_5_v_2_nell2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE66014_0_v_1_perhexiline_human RummaGEO Drug Perturbation Signatures 1.0 null CORL47 CCLE Cell Line Gene Expression Profiles -1.0 -1.9663 POLR2A_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.57273 Kidney Chromophobe_KICH_TCGA-KN-8427-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cell COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 ZNF740 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 320.284 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.8946 H3K4me3_fibroblast of gingiva_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null AD-16-HL96_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.615224 CC-17-JL38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.646 SARS-CoV_0Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.84119 Urogenital Abnormalities CTD Gene-Disease Associations 1.0 1.03271 NCIH446 DepMap CRISPR Gene Dependency 1.0 2.16717 ZBTB33_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199204,GSE211619_4_v_2_glutamine_human RummaGEO Drug Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-CS-6666-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WH7G-0326-SM-3NMBH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.935481 CDK18 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13987 G141 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.856529 BCLAF1 ENCODE Transcription Factor Targets 1.0 null GSE202434,GSE202438_4_v_0_talazoparib_human RummaGEO Drug Perturbation Signatures -1.0 null SRF ENCODE Transcription Factor Targets 1.0 null GTEX-VUSH-0004-SM-3P61T GTEx Tissue Sample Gene Expression Profiles 1.0 0.863548 ZFP281-18757296-E14-MOUSE ChEA Transcription Factor Targets 2022 1.0 null primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.29537 SREBP1-19666523-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BACH1 ENCODE Transcription Factor Targets 1.0 null GTEX-P44H-0226-SM-2XCEU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.05014 GTEX-QXCU-0008-SM-48FCH GTEx Tissue Sample Gene Expression Profiles 1.0 0.920498 GSE154577_7_v_12_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE148066,GSE157787_5_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE210580_4_v_1_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-544b TargetScan Predicted Conserved microRNA Targets 1.0 0.37496 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A622-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-P4QT-0626-SM-3NMCP GTEx Tissue Sample Gene Expression Profiles 1.0 0.853583 MYC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tonsil_8e1 HPA Tissue Sample Gene Expression Profiles 1.0 1.27325 GSE154577_2_v_9_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.057315 H3K36me3_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.04933 Declive (VI), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48229 PMC8528285-pbio.3001085.s010.xlsx-Fig_7E-MAX_WT_TESTES_MAX Rummagene Transcription Factor Associations 2026 1.0 null MAX_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.7275 NCIH524 CCLE Cell Line Gene CNV Profiles -1.0 -1.58355 GTEX-R55D-1426-SM-48FEN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.33433 POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4651_KO_Tip55_SRP134924 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -6.81555 ESR1 ENCODE Transcription Factor Targets 1.0 null MAP2K4_knockdown_62_GSE19091 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.49581 Sarcoma_SARC_TCGA-FX-A3RE-01A-11R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Blood TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PMC13137955-ijbsv22p4243s2.xlsx-Sheet1-hTFtarget_E2F3_E2F3 Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA4-21415370-HL-1-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE214931_2_v_0_temozolomide_human RummaGEO Drug Perturbation Signatures -1.0 null H3K36me3_cardiac mesoderm_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE210718_1_v_0_shmt2_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-UJHI-0626-SM-3DB8T GTEx Tissue Sample Gene Expression Profiles -1.0 -0.928415 RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.988421 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.11974 GSE43041,GSE43044_0_v_1_ldb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null superficial stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2988 H3K4me3_keratinocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_U-87 MG_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null macromolecular complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040298 Adrenal gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 brain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 r8 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36053 PMC9270251-mmc2.xlsx-2_Filtered_DEGs_Control_vs_KD_2-Gene_ID_AR Rummagene Transcription Factor Associations 2026 1.0 null prednisolone_homo sapiens_gpl570_gse32962 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null D502MG DepMap CRISPR Gene Dependency 1.0 2.44266 GSE130383_2_v_3_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null POU2F2_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cardiac fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TE5 CCLE Cell Line Gene Expression Profiles -1.0 -1.55309 A-431 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.16239 ZD-18-MI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.374042 III, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.18973 H3K4me3_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null preoptic region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.54449 CEBPB-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HCC2885 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19589 GTEX-XQ3S-0006-SM-4BOQ4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.868302 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.59311 YY1_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NR3C1 ENCODE Transcription Factor Targets 1.0 null PRSS23 Pathway Commons Protein-Protein Interactions 1.0 null Perturb_7990_KD_GPRC5C_ERP125638 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.94394 GTEX-WWYW-0426-SM-3NB31 GTEx Tissue Sample Gene Expression Profiles 1.0 0.848591 ARPC2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03518 CHD2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.62284 Cortical amygdalar area, posterior part, lateral zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09268 r4 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06664 SIN3A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE150049_2_v_0_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_cardiac mesoderm_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null EBF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 36.3318 GTEX-UPJH-0326-SM-3GADU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.930109 NCI-H2452 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00655 Lung adenocarcinoma_LUAD_TCGA-35-3615-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE191021_1_v_0_nono_human RummaGEO Gene Perturbation Signatures 1.0 null GSE120612_7_v_0_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-X4XY-0226-SM-4E3IZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09196 superficial stratum of TPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24633 ZNF143_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_GM12892_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.6255 GSE158834_12_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null periventricular stratum of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16509 H3K36me3_cardiac mesoderm_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RU1J-0006-SM-2TF6M GTEx Tissue Sample Gene Expression Profiles 1.0 1.71847 GTEX-U3ZH-0326-SM-3DB7A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.946681 Aril TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.545 MYBL2 ChEA Transcription Factor Targets 1.0 null PMC9170563-12885_2022_9665_MOESM3_ESM.docx-0-Candidata_target_genes_of_CEBPB_4_CEBPB Rummagene Transcription Factor Associations 2026 1.0 null GABPA_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NSL complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.866 EP300_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1-22096565-GC-B-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC10082046-41467_2023_37049_MOESM7_ESM.xlsx-Sheet1-Supplementary_Data_4_Genes_upregulated_in_ASPS-KY_cells_by_ASPSCR1-TFE3_knockdown_TFE3 Rummagene Transcription Factor Associations 2026 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3XB-01A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUM 52PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09712 H3K36me3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTNNB1-20615089-FETAL_BRAIN-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Tonsil TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Leber congenital amaurosis_Retina_GSE3249 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.14358 GSE121866_1_v_3_six4_human RummaGEO Gene Perturbation Signatures 1.0 null BC-54-ON71_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.33324 GTEX-U3ZM-0926-SM-4DXSW GTEx Tissue Sample Gene Expression Profiles 1.0 0.947557 GSE102505_4_v_3_tunicamycin_human RummaGEO Drug Perturbation Signatures 1.0 null FD-15-HD09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.501241 ELK1-22589737-MCF10A-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null AE-39-DG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.03734 SNU869 CCLE Cell Line Gene Expression Profiles -1.0 -2.25868 KLF15_KO_GDS4780_419_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null UACC-893 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.30161 YD-49-HM53_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.55551 GSE158834_11_v_8_palm_human RummaGEO Gene Perturbation Signatures 1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_S8E-GENE_LIST_UPLOADED_TO_ENRICHR_MNT_KO_3T3_ONLY_2084_GENES_MNT Rummagene Transcription Factor Associations 2026 1.0 null r5 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02791 PBX3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1 ENCODE Transcription Factor Targets 1.0 null ERA-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A194-01A-11R-A18U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE205163,GSE205164_5_v_8_znf808_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFG8-0126-SM-4LVMH GTEx Tissue Sample Gene Expression Profiles 1.0 1.34414 occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.50086 BCOR-27268052-CHIP-SEQ-BCELLS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-POMQ-0008-SM-48TE7 GTEx Tissue Sample Gene Expression Profiles 1.0 2.94545 GTEX-R55G-0326-SM-48FDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1312 H3K27ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-T5JW-0005-SM-3GADE GTEx Tissue Sample Gene Expression Profiles 1.0 1.45236 SARS-CoV MA15_Day4_None_GSE49263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.59427 Skin Cutaneous Melanoma_SKCM_TCGA-FW-A3TU-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null shell part of the anterobasal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.60009 OCUM1 DepMap CRISPR Gene Dependency 1.0 2.21927 SNG-M Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.96779 H3K4me2_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ChIP_JARID1A_20064375 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ELK1 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-SJXC-1226-SM-4DM78 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.845476 NB17 DepMap CRISPR Gene Dependency 1.0 2.28014 496100586_HIP_no dementia_no TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.27046 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.85166 GSE158834_7_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null H3K9ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me2_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03832 Primary hyperoxaluria DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.192 GSE158834_7_v_6_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE158834_1_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null Drug-Induced Liver Injury CTD Gene-Disease Associations 1.0 1.32015 SRF_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_astrocyte of the spinal cord_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE77108_0_v_9_saha_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158834_2_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null STAT3_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-6590-01A-12R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Colorectum TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BHLHE40 ENCODE Transcription Factor Targets 1.0 null FOXM1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1755 CCLE Cell Line Gene CNV Profiles -1.0 -2.03951 KYSE150 CCLE Cell Line Gene Expression Profiles 1.0 1.41893 Primary immunodeficiency disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.601 GSE57871_5_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CREB1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39402 STAT3_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_11_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CHD7 ENCODE Transcription Factor Targets 1.0 null PPARG-20887899-3T3-L1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-UJHI-0006-SM-3DB8H GTEx Tissue Sample Gene Expression Profiles 1.0 1.59268 GSE135030_11_v_6_fludarabine_human RummaGEO Drug Perturbation Signatures -1.0 null hsa-miR-4699-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.145356 periaqueductal gray substance, ventral portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16611 Her2_OE_GSE43730_683_human_MCF10A cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me3_keratinocyte_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23827 KAT2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lsd1/2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.796 Leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.937 H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SMC3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZKSCAN1 ENCODE Transcription Factor Targets 1.0 null GSE93124_0_v_1_crizotinib_human RummaGEO Drug Perturbation Signatures 1.0 null TET1-21490601-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PAX5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-0006-SM-2I3FJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.22477 OVTOKO Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.830435 amygdaloid complex_17 pcw_F_12880 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03168 GSE112761,GSE112767_2_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-OHPM-0326-SM-33HCA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.887337 H3K9ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE206516,GSE206518_5_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null CAL 54 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07011 medial amygdala, posteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02022 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-4865-01A-02R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA ENCODE Transcription Factor Targets 1.0 null NCI-H1666 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03832 GTEX-OHPK-1326-SM-3MJGN GTEx Tissue Sample Gene Expression Profiles 1.0 0.937626 ESR1_ECC-1_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOS ENCODE Transcription Factor Targets 1.0 null H3K4me2_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MED31 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.02759 HCFC1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletalmuscle_e HPA Tissue Sample Gene Expression Profiles -1.0 -1.09788 TBC1D2B CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13592 GTEX-OHPK-1626-SM-2YUN3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.881166 GSE148010,GSE148120_3_v_2_tet2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_Caco-2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney Diseases CTD Gene-Disease Associations 1.0 1.05386 GTEX-SIU8-0526-SM-2XCDP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.8183 GSE97352_1_v_2_dasatinib_human RummaGEO Drug Perturbation Signatures 1.0 null 496100338_HIP_probable Alzheimer's disease_no TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.68337 EFNA2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00526 POLR2A_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC10153265-media-3.xlsx-BENPORATH_NANOG_TARGETS_v2023_1-STANDARD_NAME_NANOG Rummagene Transcription Factor Associations 2026 1.0 null PMC11874984-Supplemental_Tables.docx-10-ZBTB16_ZBTB16 Rummagene Transcription Factor Associations 2026 1.0 null GSE158834_7_v_5_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MAZ_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nucleolus COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.248216 USF2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE191037_0_v_1_itraconazole_human RummaGEO Drug Perturbation Signatures -1.0 null Colon TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 primary motor cortex (area M1, area 4)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.968702 central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null dorsolateral part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08305 KU1919 DepMap CRISPR Gene Dependency 1.0 2.82212 Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null uterine cervix TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Hyperplasia CTD Gene-Disease Associations 1.0 1.61365 CMK86 CCLE Cell Line Gene CNV Profiles -1.0 -1.35602 2561_EIF4A3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.598544 XRN2-22483619-HELA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null layer 1 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34225 H3K27ac_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE151612_4_v_7_pracinostat_human RummaGEO Drug Perturbation Signatures -1.0 null BT549 CCLE Cell Line Gene Expression Profiles 1.0 1.87364 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4696-01A-01R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BL2731 (SIN3A) NURSA Protein Complexes 1.0 null C84 DepMap CRISPR Gene Dependency 1.0 2.10921 intracellular membrane-bounded organelle GO Cellular Component Annotations 2025 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-GN-A263-01A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TCF12_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPIC-0226-SM-3GADO GTEx Tissue Sample Gene Expression Profiles 1.0 0.837595 H3K4me2_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE100863,GSE100864_3_v_0_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null JARID1A-20064375-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null ABL1_knockdown_144_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.20475 GABPA_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-5329-01A-01R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JUND_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100362_FWM_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.25881 H3K4me3_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BCOR complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.47 molecular layer of CbVCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21189 A-375 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01227 KMS-12-PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.27078 COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23832 GSE179974_3_v_1_carboplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H1_BMP4_Derived_Trophoblast_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.921509 FD-91-OK66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.60552 496100316_TCx_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.24406 OCILY3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE CCLE Cell Line Proteomics 1.0 3.0548 posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.866798 PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-PBX3-Members_of_the_PBX3_regulon_as_identified_by_SCENIC_PBX3 Rummagene Transcription Factor Associations 2026 1.0 null MAPK14_knockdown_139_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.50663 PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3 Rummagene Transcription Factor Associations 2026 1.0 null H2AFZ_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE94849_1_v_2_pinometostat_human RummaGEO Drug Perturbation Signatures 1.0 null PMC8190596-mmc2.xlsx-RUNX1_mut-RUNX1_mut_RUNX1 Rummagene Transcription Factor Associations 2026 1.0 null H3K9ac_Peripheral Blood Mononuclear Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null SP5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 92.2653 basomedial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.905771 H3K4me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE104022_1_v_0_tamoxifen_mouse RummaGEO Drug Perturbation Signatures -1.0 null HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.918557 H3K4me3_fibroblast of upper leg skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null JHU-029 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.60636 Pparg::Rxra JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 41.8137 REST_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MFE296 CCLE Cell Line Gene Expression Profiles 1.0 1.50455 Perturb_1831_KO_Irf9_SRP149944 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 GTEX-WL46-0011-R9A-SM-3MJFP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06345 GSE57871_1_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null ZBTB7B JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.2748 H3K27ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PE/CA-PJ15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.916101 SW1783 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.56193 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.888227 GSE86507,GSE86509_7_v_1_hoxb7_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC7788918-13058_2020_1379_MOESM2_ESM.xlsx-S9-S9_limma_voom_differentially_expressed_genes_ESR1_depleted_recurrences_vs_matched_primaries_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null 1716_CNOT1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.609674 GTEX-T5JC-0008-SM-4DM6A GTEx Tissue Sample Gene Expression Profiles 1.0 1.49952 superficial stratum of isBI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17931 COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.3733 GTEX-TMZS-0326-SM-3DB9P GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12352 3818_HMBOX1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.507245 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17Z-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OXRK-0826-SM-2HMK7 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16695 Uterus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 ott1_22490678_hematopoietic_stem_cell_lof_mouse_gpl8321_gds4315 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.003807 RL95-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null Uvula (IX), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.07794 H3K27ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-97-8179-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SNOS-0006-SM-32PLH GTEx Tissue Sample Gene Expression Profiles 1.0 1.34842 cerebellar cortex_11 yrs_F_12289 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.70553 BD-96-HO33_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.04572 OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832513 SP1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MCF12A Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.768194 orbital frontal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.938569 Intercalated nucleus of amygdala Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.15146 POLR1C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.37807 CTCF_GM12872_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F4-21247883-LYMPHOBLASTOID-HUMAN ChEA Transcription Factor Targets 2022 1.0 null TCF3-18347094-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Megakaryoblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.528 hippocampus (hippocampal formation)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.05353 CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.978243 POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ELK4 ENCODE Transcription Factor Targets 1.0 null primary auditory cortex (core)_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.845936 GSE142210_9_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null MA-06-DJ95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203174 YY1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUND_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-573 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 GSE148066,GSE157787_3_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null medial (main) part of Med Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.98605 KLF15_KO_GDS4780_509_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BB-86-BE19_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.58616 SW900 CCLE Cell Line Gene CNV Profiles 1.0 1.43761 H3K27ac_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040975 male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE80446_0_v_1_anakinra_mouse RummaGEO Drug Perturbation Signatures 1.0 null Peripheral blood TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 acute myeloid leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.00119 Transplanted Heart Complication_Myocardial tissue_GSE582 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.56379 RPE1SS119 DepMap CRISPR Gene Dependency 1.0 2.92319 OCT4-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SPI1_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Leukocyte disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.029 GTEX-WOFM-0005-SM-3MJF3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.11809 Lung squamous cell carcinoma_LUSC_TCGA-68-7756-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-623 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 amygdaloid complex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.12563 GTEX-OXRL-0005-SM-3LK6A GTEx Tissue Sample Gene Expression Profiles 1.0 1.33887 GTEX-OHPL-1326-SM-3MJGG GTEx Tissue Sample Gene Expression Profiles 1.0 0.972859 GTEX-UJHI-0008-SM-4IHL1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.864643 SK-N-AS Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.59452 BCLAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null striatum_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.3503 hsa-miR-3150a-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.13535 POLR2AphosphoS2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_4618_KD_Mlx_SRP231452 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -3.19834 GTEX-S33H-1226-SM-4AD69 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04886 GTEX-S7PM-0426-SM-3NM91 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17853 Cardiovascular system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.526 H3K36me3_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE115542_2_v_0_digoxin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-W5X1-0006-SM-3GIJZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.34716 Uterine Carcinosarcoma_UCS_TCGA-NA-A4QV-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cortical amygdalar area, posterior part, medial zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27764 GSE105173,GSE105175_1_v_0_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null GSE217405_3_v_2_egfr_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null ChIP_TCF3_18347094 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BXPC3_PANCREAS CCLE Cell Line Proteomics 1.0 3.19978 GTEX-U3ZN-0226-SM-3DB8D GTEx Tissue Sample Gene Expression Profiles -1.0 -0.862339 Liver TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GSE158834_7_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null GSE139540_4_v_1_menadione_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-REY6-0826-SM-2TF4S GTEx Tissue Sample Gene Expression Profiles -1.0 -4.1697 primary visual cortex (striate cortex, area V1/17)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.99012 H3K4me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null 3649_HBE1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.546879 H3K4me3_GM12878_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BC-54-ON71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.511807 GSE120415,GSE120447_0_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Esophagus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 POLR2AphosphoS5_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-8094-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE48812_9_v_6_sulforaphane_human RummaGEO Drug Perturbation Signatures 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MP-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null HCC1937 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.70629 GTEX-SJXC-0426-SM-2XCFH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13092 OVCA420 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.34794 TOV-112D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.15792 Myeloproliferative neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.016 GC-04-UF36_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.231474 PRM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13449 KLF4-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null locus ceruleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.969131 deferasirox_homo sapiens_gpl570_gds3558 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-X15G-0005-SM-3NMDA GTEx Tissue Sample Gene Expression Profiles 1.0 1.80201 GATA2 ENCODE Transcription Factor Targets 1.0 null H3K4me3_GM06990_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null NCO2 DepMap CRISPR Gene Dependency 1.0 3.60024 GTEX-P44H-0006-SM-2XCFB GTEx Tissue Sample Gene Expression Profiles 1.0 0.832472 posteromedial cortical amygdaloid area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34523 cerebellum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.8677 FOXM1 ENCODE Transcription Factor Targets 1.0 null MLL1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.703 Acute Lung Injury_Lung Tissue_GSE1871 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.80002 ETS1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE102505_4_v_2_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K36me3_H7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RVPV-0226-SM-2TF6W GTEx Tissue Sample Gene Expression Profiles -1.0 -0.883794 core-binding factor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.266 hsa-miR-4271 TargetScan Predicted Conserved microRNA Targets 1.0 0.517189 Perturb_13456_OE_Smn1_SRP366489 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 2.08455 Parasubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17931 TET1-21490601-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Targets 2022 1.0 null S1PR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.17782 GTEX-SNMC-0008-SM-4DM5A GTEx Tissue Sample Gene Expression Profiles 1.0 1.23299 JJN3 CCLE Cell Line Gene CNV Profiles -1.0 -2.29778 ETS1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WL46-0926-SM-3LK7T GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38396 H3K4me1_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r4 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15913 PBX3 ENCODE Transcription Factor Targets 1.0 null regulation of protein ubiquitination GO Biological Process Annotations 2023 1.0 null GSE158834_11_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null NRF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFATC1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsomedial hypothalamic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.934806 cortex of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19616 MAF-26560356-CHIP-SEQ-TH1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_K562_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CHD1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Immune system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.103 ntera2 HPA Cell Line Gene Expression Profiles 1.0 0.88379 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV6-01A-21R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE175883_0_v_1_dis3_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE135030_8_v_2_fludarabine_human RummaGEO Drug Perturbation Signatures 1.0 null DYNLT3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.20948 NCI-H2073 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14802 Acute myeloid leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.351 H3K4me1_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE155162,GSE155169_1_v_3_buparlisib_human RummaGEO Drug Perturbation Signatures 1.0 null uterus TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 NCI-H2110 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.00284 laterodorsal subdivision of area 8 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.849728 GTEX-OIZG-1126-SM-2HMIU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21105 GTEX-X4XX-0005-SM-3NMCS GTEx Tissue Sample Gene Expression Profiles 1.0 1.36565 YY1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GA-88-CF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.361126 intermediate part of r10B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22485 GTEX-PLZ6-0726-SM-3P619 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.55551 GTEX-QEL4-1326-SM-447AD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6834 GTEX-SUCS-0006-SM-4DM59 GTEx Tissue Sample Gene Expression Profiles 1.0 1.0455 GSE202434,GSE202438_10_v_1_talazoparib_human RummaGEO Drug Perturbation Signatures 1.0 null PRDM1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4888 YY1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XQ8I-0126-SM-4BOPL GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893124 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FF-A7CW-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U3ZM-0008-SM-4DXTQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.898423 Liver Diseases CTD Gene-Disease Associations 1.0 1.10527 DC-70-EK34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.09585 primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.90012 H3K36me3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KM-8439-01A-11R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-U4B1-0006-SM-3DB8E GTEx Tissue Sample Gene Expression Profiles 1.0 0.883645 Super elongation complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.062 embryoday10.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.07087 GTEX-XBEW-0008-SM-4AT3Y GTEx Tissue Sample Gene Expression Profiles 1.0 0.825689 SW900 CCLE Cell Line Gene Expression Profiles 1.0 1.86791 Adrenocortical carcinoma_ACC_TCGA-OR-A5L3-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K9ac_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK1_all_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null COLO704 CCLE Cell Line Gene Expression Profiles 1.0 1.42239 SALL4-22934838-CD34+-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Nervous system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.038 GTEX-XQ8I-1926-SM-4BOOK GTEx Tissue Sample Gene Expression Profiles -1.0 -1.73588 MXI1 ENCODE Transcription Factor Targets 1.0 null red nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00078 GLIS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.01585 GTEX-TKQ2-0426-SM-4DXUO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.901969 Sarcoma_SARC_TCGA-QC-A7B5-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91507 NCIH2087 CCLE Cell Line Gene CNV Profiles 1.0 1.59852 MYOD1_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null G130 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.05461 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A4OY-01A-11R-A266-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TC32 CCLE Cell Line Gene Expression Profiles 1.0 1.66388 GTEX-OXRO-1926-SM-2S1O3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925655 H3K4me3_A549_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2NE-06A-21R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ ENCODE Transcription Factor Targets 1.0 null GTEX-REY6-0626-SM-2TF4G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14186 ZBTB7C JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.7802 DHL-4 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.432 periventricular stratum of r4Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15913 parolfactory gyri, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.0397 MDA-MB-134-VI Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.06772 LC-12-VN85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.307126 GTEX-PSDG-0005-SM-3GADC GTEx Tissue Sample Gene Expression Profiles 1.0 0.885996 CTCF_lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EST1-17652178-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null UF-27-HS98_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.659747 MSANTD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2978 ETV7 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.6887 GSE158834_12_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null CRTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.06425 NCI-H1355 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.555 alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE211989_0_v_1_nlrc3_mouse RummaGEO Gene Perturbation Signatures 1.0 null nucleus GO Cellular Component Annotations 2025 1.0 null GSE158834_7_v_4_palm_human RummaGEO Gene Perturbation Signatures -1.0 null JUN ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-22-5479-01A-31R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null immune system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.519961 interstitial nucleus of Cajal, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.7627 GTEX-NPJ8-0011-R1a-SM-33HCB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20272 TAF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SREBF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of THyB-P Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.07052 GSE142210_2_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_GM12875_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ETV2::HOXB13 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.2018 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE151090_5_v_3_verteporfin_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XPT6-0226-SM-4B65L GTEx Tissue Sample Gene Expression Profiles -1.0 -0.88826 r2 liminal central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47618 SPIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 68.9913 HD-29-LW24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.88424 GTEX-WYBS-1226-SM-3NM9N GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11377 Entorhinal area, medial part, ventral zone, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24077 Hypertrophy, Left Ventricular_Myocardial tissue_GSE2459 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.55718 KDM5A ChEA Transcription Factor Targets 1.0 null hsa-miR-331-3p MiRTarBase microRNA Targets 1.0 null temporal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TEAD2_TEAD2 Rummagene Transcription Factor Associations 2026 1.0 null SREBP2-21459322-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-OOBK-0008-SM-3NB27 GTEx Tissue Sample Gene Expression Profiles 1.0 1.1354 KLF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 99.9154 Entorhinal area, medial part, ventral zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44501 anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.830242 GSE180800,GSE180801_0_v_5_tex10_mouse RummaGEO Gene Perturbation Signatures -1.0 null AC-84-QG99_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -5.52802 ZFP281-27345836-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-R53T-0226-SM-48FEH GTEx Tissue Sample Gene Expression Profiles 1.0 1.52128 paraterete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49537 SARS-ddORF6_96Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.72996 WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.03763 ZBTB24 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 63.192 NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.963774 Tuberomammillary nucleus, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.84097 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null DAUDI COSMIC Cell Line Gene Mutation Profiles 1.0 null PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-CTCF_CTCF Rummagene Transcription Factor Associations 2026 1.0 null TCF12_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null icSARA deltaORF6_60Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.36131 substantia nigra, pars compacta, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.94785 primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.04221 GSE202744_1_v_0_toyocamycin_human RummaGEO Drug Perturbation Signatures -1.0 null shsy5y HPA Cell Line Gene Expression Profiles 1.0 1.08888 GTEX-OXRL-0326-SM-2I3F2 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.925103 H3K4me3_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-7606-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-7007-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZMIZ1 ENCODE Transcription Factor Targets 1.0 null GTEX-WFG7-0826-SM-3GIKU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.883351 MDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.44617 TBL1XR1 ENCODE Transcription Factor Targets 1.0 null primary auditory cortex (core)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.906468 Lymphatic system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.335 ELK1-19687146-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K36me3_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UWB1289 DepMap CRISPR Gene Dependency 1.0 2.39348 zona incerta, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.09859 GTEX-P4PP-0326-SM-33HC4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.94925 1458_CDT1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.522636 PMC10153265-media-3.xlsx-BENPORATH_SOX2_TARGETS_v2023_1-STANDARD_NAME_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null PMC11329632-41419_2024_6969_MOESM3_ESM.pdf-91-ZNF689_ZNF689 Rummagene Transcription Factor Associations 2026 1.0 null TTC549 DepMap CRISPR Gene Dependency 1.0 2.9878 ELK1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Leukemia DisGeNET Gene-Disease Associations 1.0 null H3K4me2_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE100316_5_v_2_mtor_mouse RummaGEO Gene Perturbation Signatures 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13I-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOS_MCF 10A_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNCA_KO_GDS4153_445_mouse_Striatum - 21 month GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null FACT complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.755 ZNF770 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.1121 CCND1-20090754-RETINA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MAX_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUJ4-0008-SM-4BOQI GTEx Tissue Sample Gene Expression Profiles 1.0 1.07188 Charcot-Marie-Tooth disease type 2Y DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.014 hand TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.479702 MAF-26560356-CHIP-SEQ-TH2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-OXRO-0011-R9A-SM-3NB1X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44538 GA-88-CF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.628365 BA-84-WN26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.29942 outer CP in midlateral extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.14926 GTF2F1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052553 SNU-C1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12909 CTCF_spleen_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SA1-27219007-CHIP-SEQ-ERYTHROID-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MAFK_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null JC-06-ED36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.478319 RMUGS_OVARY CCLE Cell Line Proteomics 1.0 7.33717 E2F4_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null positive regulation of protein modification by small protein conjugation or removal GO Biological Process Annotations 2025 1.0 null CHD1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute megakaryoblastic leukemia cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.121 1197_CARS_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.555137 SARS-CoV_36Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.69764 GTEX-SUCS-1326-SM-4DM5T GTEx Tissue Sample Gene Expression Profiles 1.0 0.976605 NCIH1755 DepMap CRISPR Gene Dependency 1.0 3.0207 GTEX-VUSG-0008-SM-4KL24 GTEx Tissue Sample Gene Expression Profiles 1.0 0.942062 GSE112760,GSE112767_4_v_5_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null hematopoietic cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.079933 Chronic lymphocytic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.836 GTEX-UJMC-0005-SM-3GACU GTEx Tissue Sample Gene Expression Profiles 1.0 1.13984 H3K27ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TBP_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5678-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HCC1806 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.987585 hsa-miR-4685-3p TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7H7-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE110178_5_v_6_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE219274,GSE219276_0_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null LXF-289 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.04162 EP300_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LU65 DepMap CRISPR Gene Dependency 1.0 2.04193 BD-04-NG34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.220766 PMC12515692-MOL2-19-2882-s001.xlsx-Phosphoproteome_AKT2_KD_vs_SCR-Unnamed_3_AR Rummagene Transcription Factor Associations 2026 1.0 null JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-KU-A6H7-06A-21R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBTF ENCODE Transcription Factor Targets 1.0 null ELF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A1-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE196117_1_v_8_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null TP53-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.47213 dorsolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05852 YD8 CCLE Cell Line Gene Expression Profiles 1.0 1.60566 periventricular stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26494 STAT1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-A6DA-01A-31R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bone marrow cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.342971 PMC6744561-41467_2019_12125_MOESM7_ESM.xlsx-Normal_309_TCF7_rep1_sorted_pea-Gene_Name_TCF7 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7SF-0006-SM-3K2B6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.963754 GSE243491_1_v_0_oxaliplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of the aortic adventitia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4287 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 GSE210476_11_v_10_rutaecarpine_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-QDT8-0011-R11A-SM-32PKD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.990766 C2BBE1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.14403 GSE147959,GSE147960_5_v_3_stat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Epididymis TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K4me2_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MYOD1 ENCODE Transcription Factor Targets 1.0 null TBP ChEA Transcription Factor Targets 1.0 null POLR2A_bone marrow_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWOO-0326-SM-48TDB GTEx Tissue Sample Gene Expression Profiles 1.0 1.34077 GSE186223,GSE186224_6_v_3_hmces_mouse RummaGEO Gene Perturbation Signatures 1.0 null MYC_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of the VAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2446 GSE84922,GSE84924_0_v_1_sall4_mouse RummaGEO Gene Perturbation Signatures -1.0 null membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-X585-0005-SM-46MV3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.959368 GSE220520_6_v_8_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null r1 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.62561 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-R55C-0826-SM-48FCL GTEx Tissue Sample Gene Expression Profiles 1.0 0.830547 IRF8-22096565-GC-B-MOUSE ChEA Transcription Factor Targets 2022 1.0 null RNA polymerase I upstream activating factor complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.604 PMC6855629-pone.0225186.s009.xlsx-Sheet1-DEGs_downregulated_in_HEK293_MEIS1_KO_MEIS1 Rummagene Transcription Factor Associations 2026 1.0 null striatum_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.970187 lateral intermediate part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.46437 H2AFZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-T8EM-1326-SM-3DB7G GTEx Tissue Sample Gene Expression Profiles -1.0 -0.947862 MAZ_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 9910_XRN1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.502096 doxycycline_mus musculus_gpl2872_gse33875 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.601 GTEX-VJYA-0526-SM-4KL1R GTEx Tissue Sample Gene Expression Profiles 1.0 1.30736 7206_RCL1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.509723 EGR1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1 ENCODE Transcription Factor Targets 1.0 null GTEX-OHPL-1026-SM-3MJGI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.30302 primary auditory cortex (core)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.929081 MAX_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H2AFZ_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pyramus (VIII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.04454 POLR2A_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.870316 ETS1 ENCODE Transcription Factor Targets 1.0 null H3K4me2_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE203485_1_v_0_zdhhc2_human RummaGEO Gene Perturbation Signatures 1.0 null sirolimus_mus musculus_gpl1261_gse21755 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null GSE165548_2_v_1_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null blood GTEx Tissue Gene Expression Profiles 1.0 0.902375 negative regulation of autophagosome assembly GO Biological Process Annotations 2023 1.0 null Large cell lung cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.689 PMC4149371-pone.0105180.s010.xls-NANOG-GENE_NANOG Rummagene Transcription Factor Associations 2026 1.0 null NE-94-VE83_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.281985 colon TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Seminal vesicle TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K4me2_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_2_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null PDX1-19855005-MIN6-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null hsa-miR-92b-3p MiRTarBase microRNA Targets 1.0 null GSE199255,GSE199356_6_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE112962,GSE112963_2_v_1_ddx5_human RummaGEO Gene Perturbation Signatures -1.0 null DD-36-YH76_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -5.09319 H3K4me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null Entorhinal area, medial part, dorsal zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12432 PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-ENSG_ID_RFX2 Rummagene Transcription Factor Associations 2026 1.0 null H3K36me3_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XUW1-0008-SM-4BOQH GTEx Tissue Sample Gene Expression Profiles 1.0 0.832706 leukocyte TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K4me3_BJ_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SP4_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RUSQ-0126-SM-47JWV GTEx Tissue Sample Gene Expression Profiles 1.0 0.965683 HCV JFH1_96Hour-Huh7_5_1c2_None_GSE29889 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.07942 MXI1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletalmuscle_a HPA Tissue Sample Gene Expression Profiles -1.0 -1.04009 H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOXP3 ChEA Transcription Factor Targets 1.0 null GSE146687_2_v_5_eribulin_human RummaGEO Drug Perturbation Signatures -1.0 null FOXC1 JASPAR Predicted Transcription Factor Targets 1.0 null intracellular organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042287 H3K27ac_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-FC-A5OB-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null AsPC-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.65658 GSE148066,GSE157787_2_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ARPP19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.09633 MYBL2 ENCODE Transcription Factor Targets 1.0 null MAFF_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KURAMOCHI DepMap CRISPR Gene Dependency 1.0 3.58095 GSE80446_2_v_1_anakinra_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K36me3_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletalmuscle_b HPA Tissue Sample Gene Expression Profiles -1.0 -1.03843 parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.932583 GABPA_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-R3RS-0008-SM-48FF1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.48575 Perturb_9879_KD_ARID3a_SRP199224 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -1.87543 H3K4me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null dorsolateral IC periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13148 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7095-01A-21R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-KV-A74V-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CORL279 DepMap CRISPR Gene Dependency 1.0 2.02074 GTEX-X5EB-1826-SM-4E3K8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30827 GSE218356_1_v_0_cited1_mouse RummaGEO Gene Perturbation Signatures -1.0 null reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PAXBP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31959 TEAD4_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H847 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null PMC8384902-mmc2.xlsx-4_NEUROD1_high_subtype-Gene_Symbol_NEUROD1 Rummagene Transcription Factor Associations 2026 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.31764 MAX_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TMEM139 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0277 TEAD4 ENCODE Transcription Factor Targets 1.0 null P-TEFb complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.045 lateral ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.960308 H3K36me3_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-1426-SM-2XCDM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17365 PMC12055005-elife-101299-supp11.xlsx-hypoxia_and_3D_selective_in_DEG-RUNX3_RUNX3 Rummagene Transcription Factor Associations 2026 1.0 null Lingula (I) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.34136 hsa-miR-4476 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 H3K27ac_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC11699082-BLOODA_ADV-2023-012291-mmc1.xlsx-Sheet1-CD37_pos_corr_top100_GSE10846_CHOP_ABC_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null PMC12515692-MOL2-19-2882-s001.xlsx-Phosphoprot_AKT1_AKT2_KD_vs_SCR-Unnamed_3_AR Rummagene Transcription Factor Associations 2026 1.0 null layer 2 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00643 outer CP in primary auditory cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.837893 MXI1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BC-40-TU13_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.37845 Parietal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 2.493 TBP_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23177 Hyphal cell wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.687 VZ in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.18949 GSE192771_2_v_3_sorafenib_human RummaGEO Drug Perturbation Signatures -1.0 null ADAMTSL4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.47097 POLR2A_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SIU7-0926-SM-4BRX1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.903384 mediodorsal nucleus of thalamus_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.32666 FLI1-21571218-MEGAKARYOCYTES-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE203158_1_v_15_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null FD-20-OG99_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.311459 EA-39-YN88_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.35369 ELK1-22589737-MCF10A-HUMAN ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS5_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ELF1_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WWYW-0526-SM-3NB2W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.77648 GSE149035_1_v_5_hepacam_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-548ac TargetScan Predicted Conserved microRNA Targets 1.0 0.199275 SOX11 ChEA Transcription Factor Targets 1.0 null MACROH2A2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2655 primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.872311 USF2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.936293 CTCF_choroid plexus epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AGS Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.72016 HL-60 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.29363 ChIP_KLF4_18358816 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null AQR CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67233 Adenocarcinoma CTD Gene-Disease Associations 1.0 1.13245 RCOR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1650_LUNG CCLE Cell Line Proteomics 1.0 2.12477 TP53-22127205-IMR90-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BACH1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-60-2697-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null myeloid leukemia cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.397222 Inferior colliculus, central nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1581 GSE158834_10_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null 7275_RGS14_P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.830616 PMC6484770-41388_2018_602_MOESM5_ESM.xlsx-up_P53_vs_con-Unnamed_1_TP53 Rummagene Transcription Factor Associations 2026 1.0 null Ca9-22 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.88026 posterior (caudal) superior temporal cortex (area 22c)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.40271 superficial stratum of r1BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.62561 POLR2A_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U4B1-0008-SM-4DXUW GTEx Tissue Sample Gene Expression Profiles 1.0 1.36559 Aorta smooth muscle cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.923 H3K9ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null superficial part of arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15074 H3K4me3_cardiac mesoderm_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SLC2A6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04616 r3 liminal central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07802 GTEX-PLZ4-0008-SM-48TE6 GTEx Tissue Sample Gene Expression Profiles 1.0 0.981012 STAT4-19710469-TH1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null EP300_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null supraoptic nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.912091 MDA-MB-436 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.93642 negative regulation of protein-containing complex disassembly GO Biological Process Annotations 2023 1.0 null horizontal nucleus of the diagonal band Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.09851 Frontal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 2.386 NFIC_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRF1 Pathway Commons Protein-Protein Interactions 1.0 null MFAP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.9641 cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null Prostate gland TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 CAT CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12856 SOX2-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null GTEX-QDVJ-0008-SM-48U2E GTEx Tissue Sample Gene Expression Profiles 1.0 1.26588 organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041627 H3K4me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ELF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X5EB-2326-SM-46MW5 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.36173 Lung squamous cell carcinoma_LUSC_TCGA-56-8305-01A-11R-2296-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBC Pathway Commons Protein-Protein Interactions 1.0 null substantia nigra, pars compacta, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.73743 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BX-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredPeptides-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null CTCF_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4673 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 GTEX-U3ZG-0006-SM-47JWX GTEx Tissue Sample Gene Expression Profiles -1.0 -0.943739 NuRD complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.257 TCF3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null postcentral gyrus, left, bank of the posterior central sulcus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.859009 Charcot-Marie-Tooth disease type 2R DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.104 Medial amygdalar nucleus, posteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64634 HCFC1_ES-E14_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null fungal-type cell wall COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.616 KPNYS DepMap CRISPR Gene Dependency 1.0 2.16491 KLF4 ChEA Transcription Factor Targets 1.0 null GSE148066,GSE157787_11_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Substantia nigra, reticular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04818 RT112 CCLE Cell Line Gene CNV Profiles -1.0 -1.34948 MDST8 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.982222 MAX ENCODE Transcription Factor Targets 1.0 null GTEX-RM2N-1326-SM-48FCW GTEx Tissue Sample Gene Expression Profiles 1.0 1.12947 H3K4me3_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Osteoarthritis DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.016 H4 histone acetyltransferase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.463 mediodorsal nucleus of thalamus_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.23785 GSE224547_1_v_0_cftr_human RummaGEO Gene Perturbation Signatures 1.0 null GSE167224,GSE168147_1_v_5_hnrnpk_human RummaGEO Gene Perturbation Signatures -1.0 null Charcot-Marie-Tooth disease axonal type 2P DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.686 BRCA1 ENCODE Transcription Factor Targets 1.0 null POLR2A_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRPF38A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.30389 WT1-20215353-NEPHRON-PROGENITOR-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TCF7L2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_2-ETS1-bound_promoters_ETS1 Rummagene Transcription Factor Associations 2026 1.0 null GSE178292_0_v_2_melphalan_human RummaGEO Drug Perturbation Signatures 1.0 null suboptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.02065 Lobule II, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.82781 STAT3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null metabolism GAD Gene-Disease Associations 1.0 null CDK4_knockdown_225_GSE8866 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.88452 H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-78-7155-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE198982,GSE198986_1_v_2_daunorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null 8598_SUPT5H_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.0363 TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.4137 MORN4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08861 HL-60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.55147 GTEX-V1D1-0008-SM-4JBIJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.922203 GSE209598_0_v_3_tgfbr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null outer CP in dorsolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.938597 H2AFZ_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBTF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SIX5_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T5JW-0226-SM-4DM7I GTEx Tissue Sample Gene Expression Profiles -1.0 -1.25433 FA-36-VA24_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.75038 EMC-BAC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2A_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4384-01A-01R-1755-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lymphoid progenitor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.742 CDKN2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.32963 posteroventral (inferior) parietal cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.983417 GTEX-XBEC-1326-SM-4AT69 GTEx Tissue Sample Gene Expression Profiles -1.0 -3.09752 SIN3A_Panc1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KCNS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91847 FRA1 MotifMap Predicted Transcription Factor Targets 1.0 null GSE213588_10_v_7_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null EE-03-SG02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.222891 TIS granule COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.803 POLR2A_bone marrow macrophage_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary motor-sensory cortex (samples)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.859474 CAL-148 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.870181 inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.23118 hsa-miR-4649-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 RNAi_-666_19345177 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K4me3_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OLIG2-29049317-MOUSE-SPINALCORD ChEA Transcription Factor Targets 2022 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-7636-01A-11R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE199606_3_v_0_csf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_fibroblast of the aortic adventitia_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.977492 EFM19 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.83586 Nodulus (X), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.69185 GSE158834_11_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null ELF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128634,GSE128636_4_v_3_foxo1_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_cortical plate_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE133329_0_v_3_trim28_human RummaGEO Gene Perturbation Signatures -1.0 null intermediate part of the arcuate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04779 TAF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE128730_0_v_2_neratinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE161184_0_v_1_tlr7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE153354_0_v_1_tcf19_human RummaGEO Gene Perturbation Signatures 1.0 null BCL3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC-19030024-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NCIH1105 CCLE Cell Line Gene CNV Profiles 1.0 1.6246 H3K4me3_cardiac mesoderm_hg19_8 ENCODE Histone Modification Site Profiles 1.0 null r5 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65706 ZMYM1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62121 H3K36me3_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AB-33-EM56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -5.90861 GTEX-QESD-0008-SM-447B2 GTEx Tissue Sample Gene Expression Profiles 1.0 0.897288 CB-16-SY72_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.224113 HS578T Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.742356 PHF8_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NCIH660 CCLE Cell Line Gene CNV Profiles 1.0 2.18735 gigantocellular group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19326 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A182-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null U251MG Achilles Cell Line Gene Essentiality Profiles 1.0 1.63982 H3K4me3_WI38_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HCC2157 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.910885 Lung adenocarcinoma_LUAD_TCGA-49-4514-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD4_Naive_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.5393 H3K4me1_liver_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PMC7614775-EMS178742-supplement-Proteomics_Table_1.pdf-30-ZNF143_ZNF143 Rummagene Transcription Factor Associations 2026 1.0 null ZBTB33_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null trochlear nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.6527 lateral ventricle HPA Tissue Protein Expression Profiles -1.0 -1.61402 BT549 DepMap CRISPR Gene Dependency 1.0 2.1831 H3K4me3_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null ES-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.51295 H3K4me3_fibroblast of villous mesenchyme_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ALG10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44918 r3 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.23827 CTCF_K562_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null ISHIKAWAHERAKLIO02ER_ENDOMETRIUM CCLE Cell Line Proteomics 1.0 3.28995 U031 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.69721 GSE118548_1_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.838182 NCIH841 CCLE Cell Line Gene CNV Profiles 1.0 3.2803 muscle GTEx Tissue Gene Expression Profiles -1.0 -1.01374 GTEX-QEG5-0426-SM-2I5GJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.948101 H3K36me3_keratinocyte_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WY7C-1126-SM-3NB3A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0588 H3K4me3_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RM2N-0326-SM-48FD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.15841 GSE171724_1_v_6_ezh2_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung squamous cell carcinoma_LUSC_TCGA-94-8035-01A-11R-2247-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE184892_7_v_3_trehalose_human RummaGEO Drug Perturbation Signatures -1.0 null Head TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 EGR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4876-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null chronic myeloid leukemia cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.630718 GSE147366_1_v_4_med13_human RummaGEO Gene Perturbation Signatures 1.0 null Cytogenetically Normal Acute Myeloid Leukemia DisGeNET Gene-Disease Associations 1.0 null GTEX-X585-0008-SM-46MU4 GTEx Tissue Sample Gene Expression Profiles 1.0 0.84037 POLR2AphosphoS5_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1437 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.901507 GSE205788_0_v_1_gfap_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC2263127-pone.0001816.s001.xls-E2F3_up_Bild-Symbol_E2F3 Rummagene Transcription Factor Associations 2026 1.0 null superficial stratum of r4BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64567 GTEX-P4QS-0726-SM-3NMCZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.825285 GSE153258_1_v_0_dcp2_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-VUSG-1726-SM-4KKZL GTEx Tissue Sample Gene Expression Profiles 1.0 1.1068 GTEX-RWSA-0626-SM-2XCBD GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24616 GTEX-WI4N-0726-SM-3TW93 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893304 nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null blood cancer cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.067087 A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB1-F2del_18Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.66818 Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6796-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Hypertrophy CTD Gene-Disease Associations 1.0 1.15933 Perturb_4327_KO_Zcchc8_SRP187429 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 5.2008 GSE130217_5_v_3_sesn2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me1_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE169571_5_v_4_dexamethasone_mouse RummaGEO Drug Perturbation Signatures -1.0 null CFPAC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08811 Autoimmune thyroiditis DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.601 NFIC ENCODE Transcription Factor Targets 1.0 null Immune system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.601 YY1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -3.08899 DB-21-FY75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.19812 medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.89978 SMARCB1 ENCODE Transcription Factor Targets 1.0 null U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.31333 ECGI10 CCLE Cell Line Gene CNV Profiles 1.0 2.00142 REST_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ7-0011-R9a-SM-2TC5R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0682 Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Aorta cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.923 COLO678 CCLE Cell Line Gene Expression Profiles -1.0 -1.84198 postcentral gyrus, left, superior lateral aspect of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.888158 GTEX-U8XE-1726-SM-4E3IF GTEx Tissue Sample Gene Expression Profiles 1.0 1.33284 GSE213588_10_v_4_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_fibroblast of villous mesenchyme_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-let-7e-3p MiRTarBase microRNA Targets 1.0 null UM-UC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.09025 PML ENCODE Transcription Factor Targets 1.0 null GTEX-TML8-0005-SM-32QPA GTEx Tissue Sample Gene Expression Profiles 1.0 1.09398 FOSL2_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00465 GTEX-TML8-0526-SM-32QOQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13494 Zbtb2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.3896 GTEX-RU72-0011-R9A-SM-2TF67 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56659 A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_2day-MOI-10^3_None_GSE43302 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.84349 Brain Lower Grade Glioma_LGG_TCGA-DU-7008-01A-11R-2027-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ChIP_THAP11_20581084 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE130383_1_v_3_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null CE-96-GH46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.238216 H3K4me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE88819_11_v_4_tug1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null negative regulation of macroautophagy GO Biological Process Annotations 2025 1.0 null GSE238116_1_v_2_egr1_human RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_SK-N-MC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null inner CP in dorsomedial frontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15734 WC-09-GD62_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.562179 H3K4me1_CH12.LX_mm9_4 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2803 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.830435 ZBTB7A ENCODE Transcription Factor Targets 1.0 null GSE169205_3_v_5_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null Autoimmune disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.601 superficial stratum of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.45088 Superior olivary complex, periolivary region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02104 H3K4me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POU2F2 ENCODE Transcription Factor Targets 1.0 null H3K9ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null WRNIP1 ENCODE Transcription Factor Targets 1.0 null central glial substance Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05522 lymphnode_5a HPA Tissue Sample Gene Expression Profiles 1.0 1.95638 CL-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null striatum_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.19033 BC-56-CP81_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.285147 substantia nigra reticulata, isthmic part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18059 MAZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_0_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-S7PM-0011-R6A-SM-3NM8F GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5969 GSE92457_7_v_8_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null periventricular stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72811 H3K4me1_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SP in entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.896914 Perturb_413_OE_GPD1_SRP252809 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 GTEX-R55C-0326-SM-3GAF1 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.566 XRN2 ChEA Transcription Factor Targets 1.0 null MYC_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null plicamycin_homo sapiens_gpl570_gse25127 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null hESC_Derived_CD56+_Ectoderm_Cultured_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.26567 HDQP1_BREAST CCLE Cell Line Proteomics 1.0 2.15495 SOX11-23321250-Z138-A519-JVM2-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null GSE103068_5_v_4_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null KB-46-EJ60_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.83943 MYC_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE207582_2_v_1_testosterone_mouse RummaGEO Drug Perturbation Signatures 1.0 null CHSA0011 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.98288 PPIH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.31605 CROCC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.85634 dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25347 paravermis of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.837382 respiratory system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054394 Nuclear pore central transport channel COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.118 superficial stratum of THyB-I Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54994 COL4A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.816 IKZF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT1 ENCODE Transcription Factor Targets 1.0 null Idiosyncratic drug effect_Hepatic Tissue_GSE2825 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.65208 BD-96-HO33_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.215935 OE-84-HO42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.454745 STAT3_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XLM4-2026-SM-4AT4X GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841988 H3K4me3_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE242199_6_v_7_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null PMC5640240-ppat.1006668.s013.xlsx-BETA4-379_common_elements_in_shEP400-1_BETA_shEP400-3_BETA_shMYCL_BETA_and_shEP400-2_BETA_BHLHE23 Rummagene Transcription Factor Associations 2026 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MR-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NURF complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.451 E2F6_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-2326-SM-2XCAW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40948 MTA3 ENCODE Transcription Factor Targets 1.0 null GSE196962_4_v_3_parg_human RummaGEO Gene Perturbation Signatures 1.0 null TCF12_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMR6-0011-R4A-SM-32PKU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13052 H3K4me3_mammary epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.882347 GSE193258,GSE193259_9_v_13_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XAJ8-0126-SM-47JYG GTEx Tissue Sample Gene Expression Profiles 1.0 0.828107 Brain Lower Grade Glioma_LGG_TCGA-P5-A72Z-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MYBL2-22936984-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null KDM4A ENCODE Transcription Factor Targets 1.0 null Thyroid gland disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.48 EP300_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_mammary epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-A6EP-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-6394-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null adrenal gland GTEx Tissue Gene Expression Profiles 1.0 2.14345 GSE186287_2_v_0_ufm1_human RummaGEO Gene Perturbation Signatures 1.0 null BD-73-TX58_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.295633 HDAC2 ENCODE Transcription Factor Targets 1.0 null GTEX-S4P3-0426-SM-4AD56 GTEx Tissue Sample Gene Expression Profiles 1.0 0.913899 MTA3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null X, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.865447 Childhood leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.137 medial geniculate complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.99175 superficial stratum of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19654 POLR2AphosphoS2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_BJ_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null DLD-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GTEX-Q2AG-0426-SM-2S1PU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14491 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AU-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAGA-type complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.222 Immune system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.335 Central lobule Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28946 Perturb_4619_KD_Rfx1_SRP231452 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.84881 TRIM28 ENCODE Transcription Factor Targets 1.0 null Thoracic disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.095 SU-DHL-10 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.938694 H3K9ac_Stomach Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NOMO1 Achilles Cell Line Gene Essentiality Profiles 1.0 1.16509 hsa-miR-3614-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 JHESOAD1 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.10303 Hs-746T Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.96271 inner portion of lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03155 AD-51-SS86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.22184 2622_EMG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.711198 H3K4me3_fibroblast of skin of abdomen_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.05292 FD-59-TC81_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.239928 KA-81-AG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -5.03497 H3K9ac_heart_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4776-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Myocardial Infarction dbGAP Gene-Trait Associations 1.0 0.017487 GTEX-S3XE-2026-SM-3K2B5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3527 CTBP2 ENCODE Transcription Factor Targets 1.0 null CTCF_brain microvascular endothelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 6239_PFDN4_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.600911 U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.80509 GTEX-OHPK-0006-SM-2HMKH GTEx Tissue Sample Gene Expression Profiles 1.0 1.27354 Cortical amygdalar area, posterior part, lateral zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.38797 PD-70-VS77_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.241545 CTCF-33576154-HUMAN-LIVER-PROSTATECANCER ChEA Transcription Factor Targets 2022 1.0 null PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Downregulated_NR2F1 Rummagene Transcription Factor Associations 2026 1.0 null SOX2-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null cerebral cortex HPA Tissue Protein Expression Profiles -1.0 -1.03006 FB-85-ND09_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.206955 amygdaloid complex_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.43887 occipital neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.95631 SMC3_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A6AO-01A-11R-A30B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HELQ CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18283 GSE149264,GSE149267_4_v_1_trp53_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QDT8-0526-SM-3NMD8 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.878043 COLO 853 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.904886 OVCAR4_OVARY CCLE Cell Line Proteomics 1.0 5.32277 GSE148066,GSE157787_3_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null KLF4-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null MDAMB436 CCLE Cell Line Gene CNV Profiles 1.0 2.42078 H3K36me3_astrocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-POYW-1326-SM-48TCG GTEx Tissue Sample Gene Expression Profiles 1.0 0.915932 MCF7 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.1355 PANC0813 DepMap CRISPR Gene Dependency 1.0 2.46627 POLR2A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventral part of THyB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12013 G28T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.58536 RT112 Achilles Cell Line Gene Essentiality Profiles 1.0 1.43867 ZMIZ1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF12_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL851 CCLE Cell Line Gene CNV Profiles 1.0 1.36553 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.63463 PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA_high-signal_selected_bound_promoters_GABPA Rummagene Transcription Factor Associations 2026 1.0 null B3GNT4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19465 GSE210580_3_v_12_rag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H4K20me1_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE221356_1_v_0_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE93156_1_v_0_idelalisib_human RummaGEO Drug Perturbation Signatures -1.0 null EML4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03493 ZBTB33 ENCODE Transcription Factor Targets 1.0 null GSE147876,GSE147877_2_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null AF-99-HA02_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.484357 GTEX-WXYG-0005-SM-3NB3M GTEx Tissue Sample Gene Expression Profiles 1.0 1.86521 RPL21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29695 PAX5 ENCODE Transcription Factor Targets 1.0 null DEL DepMap CRISPR Gene Dependency 1.0 2.23887 GSE214212_2_v_1_chd6_human RummaGEO Gene Perturbation Signatures 1.0 null GSE215351,GSE215794_1_v_3_kdm8_mouse RummaGEO Gene Perturbation Signatures 1.0 null Vascular disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 0.526 parvocellular part of r8LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76282 HDAC2_Deficiency_GDS2624_658_mouse_Embryonic heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GTEX-QMRM-0526-SM-2I5GA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0613 ARHGEF9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54809 SPI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Hypotensive episode_Renal Tissue_GSE2401 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.27149 QA-50-YO37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.85388 GSE165548_2_v_13_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE155836,GSE155839_3_v_2_alvocidib_human RummaGEO Drug Perturbation Signatures -1.0 null ventrolateral preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06498 GTEX-TSE9-0526-SM-3DB7Z GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3466 pancreas GTEx Tissue Gene Expression Profiles -1.0 -1.59918 GSE120413,GSE120447_4_v_5_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CTCF_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_splenic B cell_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE110268_0_v_3_foxd1_human RummaGEO Gene Perturbation Signatures -1.0 null SP in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.969878 Organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.658 GSE148066,GSE157787_2_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CTU1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22415 GSE146982_3_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null tonsil HPA Tissue Gene Expression Profiles 1.0 1.73493 anteroventral periventricular preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0848 PMC8045971-Table_3.xlsx-vs_LPS_ctrl-Unnamed_4_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE206516,GSE206518_0_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null CSNK2A1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.43862 mantle zone of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37261 ELK4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 44.6878 PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_targets-genes_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of pedal digit skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HCT116_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_B cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_GM12865_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TAF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AI-0006-SM-2I3FG GTEx Tissue Sample Gene Expression Profiles 1.0 0.979889 ZC3H11A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPIC-1026-SM-4IHLT GTEx Tissue Sample Gene Expression Profiles 1.0 0.842274 HMGN3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 501A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.9823 GTEX-XAJ8-0006-SM-46MVM GTEx Tissue Sample Gene Expression Profiles 1.0 2.87308 GTEX-OHPN-0011-R2A-SM-2I5FB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.1695 9073_TMEM41B_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.517439 PMC5840266-41598_2018_22384_MOESM13_ESM.xlsx-UBE3A_KD_significant-Unnamed_23_AR Rummagene Transcription Factor Associations 2026 1.0 null parietal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-XK95-0008-SM-4AT5G GTEx Tissue Sample Gene Expression Profiles 1.0 0.864069 Lung adenocarcinoma_LUAD_TCGA-55-A492-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.98823 SIX5_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IC-76-JU42_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.21405 GTEX-XOT4-0526-SM-4B66O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62161 EEF1D Pathway Commons Protein-Protein Interactions 1.0 null Prostate adenocarcinoma_PRAD_TCGA-FC-A6HD-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-O5YT-0007-SM-32PK7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.98527 AC-92-HS43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.267728 SuperiorCervicalGanglion BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.18528 GTEX-QMR6-0011-R5A-SM-32PKT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17159 H3K27ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of IC Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13211 SARS-BatSRBD_84Hour_23935999_GSE47962 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.82236 Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.564 PMC12224929-ADVS-12-2416784-s006.xlsx-DEG_circGLIS3_KD-Unnamed_6_AR Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null estradiol_mus musculus_gpl4134_gse23072 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Zinc finger, FYVE/PHD-type InterPro Predicted Protein Domain Annotations 1.0 null AD-16-HL96_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.211302 viscus TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GTEX-X4XY-0011-R8A-SM-46MVC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.64186 primary auditory cortex (core)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.0166 bonemarrow_5a HPA Tissue Sample Gene Expression Profiles -1.0 -2.85836 Nucleolus organizer region COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.513 GSE128333_2_v_0_tcf4_human RummaGEO Gene Perturbation Signatures 1.0 null periventricular stratum of r8Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36098 ZKSCAN3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.4 GSE196259_2_v_0_gcm1_human RummaGEO Gene Perturbation Signatures 1.0 null blast cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061981 GSE131798,GSE131804_1_v_0_igf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE156667_0_v_1_lrrc8a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Annulus fibrosus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.945 GSE213588_10_v_0_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null MYC_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cecum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_0Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.598736 ETV6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.493 GSE231799_3_v_5_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE195663_0_v_3_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null WT1-20215353-NEPHRON PROGENITOR-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null YY1_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OOBJ-0006-SM-2I3F4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.16377 POLR2AphosphoS5_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null INTS5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.63854 GTEx Nerve 20-29 vs 50-59 GTEx Tissue-Specific Aging Signatures -1.0 -6.33901 Bm TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.159 GSE114992,GSE114993_0_v_3_irf5_mouse RummaGEO Gene Perturbation Signatures -1.0 null THAP11 ChEA Transcription Factor Targets 1.0 null PAX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYBL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4728-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 Infertility, Male CTD Gene-Disease Associations 1.0 1.13177 GTEX-UPJH-0526-SM-4IHK8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.94845 female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 4578_LIG1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.09798 gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.17577 GSE193258,GSE193259_2_v_3_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-U4B1-1626-SM-3DB8N GTEx Tissue Sample Gene Expression Profiles -1.0 -0.969859 Rectum adenocarcinoma_READ_TCGA-G5-6641-01A-11R-A32Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAPK1_knockdown_145_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.15196 CW9019 DepMap CRISPR Gene Dependency 1.0 2.09631 Set1C/COMPASS complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.439 GTEX-S4Z8-0006-SM-3K2AQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.72218 GSE148066,GSE157787_3_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null NCI-H841 COSMIC Cell Line Gene CNV Profiles 1.0 4.51153 GTEX-SIU8-0226-SM-2XCDS GTEx Tissue Sample Gene Expression Profiles -1.0 -0.840831 whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-TSE9-0726-SM-3DB8C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36506 BL2728 (SIN3A) NURSA Protein Complexes 1.0 null periventricular stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72965 GTEX-RTLS-0426-SM-2TF5K GTEx Tissue Sample Gene Expression Profiles -1.0 -0.93561 GTEX-WL46-0726-SM-3LK5Z GTEx Tissue Sample Gene Expression Profiles -1.0 -0.892616 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5006-01A-01R-1334-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-NPJ7-0011-R5a-SM-33HBK GTEx Tissue Sample Gene Expression Profiles -1.0 -0.860332 Hoxa13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.1354 Lung adenocarcinoma_LUAD_TCGA-55-8090-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZFP281-18757296-E14-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.872719 GSE220520_6_v_9_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null ventromedial preoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.27131 TAF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CHEK1_knockdown_142_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.31271 PMC10247733-41408_2023_863_MOESM2_ESM.pdf-383-PGR_PGR Rummagene Transcription Factor Associations 2026 1.0 null NCI-H2196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.36136 Skin Cutaneous Melanoma_SKCM_TCGA-QB-A6FS-06A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cardiovascular system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50313 Nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me3_SK-N-SH_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null layer III of rostral entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.01505 GSE158834_7_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null ZNF281 ChEA Transcription Factor Targets 1.0 null ELK1 ENCODE Transcription Factor Targets 1.0 null POLR2AphosphoS5_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZSWIM9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.14675 PMC12575911-43556_2025_329_MOESM2_ESM.xlsx-SD2_MITF_CoBindingGenes-Gene_MITF Rummagene Transcription Factor Associations 2026 1.0 null 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.19629 Hematologic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.854 Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null outer CP in rostral cingulate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.848188 medial vestibular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.56853 GTEX-S341-0126-SM-4AD64 GTEx Tissue Sample Gene Expression Profiles 1.0 1.28058 GTEX-S7SE-0226-SM-2XCD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.954308 GSE241036_0_v_3_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null HRC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.12425 CTCF_GM06990_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Vermiform appendix TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-PKNOX1_mod_PKNOX1 Rummagene Transcription Factor Associations 2026 1.0 null KDM5B_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_HEK293_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.24627 GSE210101,GSE210114_7_v_9_urod_human RummaGEO Gene Perturbation Signatures -1.0 null GSE152734,GSE152735_1_v_0_pbrm1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE205963_0_v_1_tet2_mouse RummaGEO Gene Perturbation Signatures -1.0 null UBLC1 CCLE Cell Line Gene Expression Profiles -1.0 -1.67667 H3K4me3_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null TET1 ChEA Transcription Factor Targets 1.0 null H3K4me3_A549_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null embryoday9.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.11799 YY1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NFATC1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_G1E-ER4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null KDM5A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWCY-0008-SM-48TE9 GTEx Tissue Sample Gene Expression Profiles 1.0 1.21209 GTEX-WYVS-0006-SM-3NMA7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.00335 GSE220520_3_v_7_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null Degenerative disc disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.015 YE-55-YX75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.294465 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.07002 ELF1 ENCODE Transcription Factor Targets 1.0 null hsa-miR-548ae TargetScan Predicted Conserved microRNA Targets 1.0 0.226173 GTEX-SJXC-0526-SM-2XCFG GTEx Tissue Sample Gene Expression Profiles -1.0 -3.07463 GSE192689_0_v_1_ricin_mouse RummaGEO Drug Perturbation Signatures -1.0 null LRRC8D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.03157 H3K9ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CASP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18924 Bone marrow cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SIN3A_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU449_LIVER CCLE Cell Line Proteomics 1.0 3.44925 GTEX-QCQG-2126-SM-2S1P8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.19251 OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20196 Lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 K562 Achilles Cell Line Gene Essentiality Profiles 1.0 1.43992 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IF-01A-11R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE192771_2_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null Muscle - Skeletal GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.19616 cerebellar cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06195 H3K4me3_SK-N-MC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XV7Q-1126-SM-4BRVS GTEx Tissue Sample Gene Expression Profiles 1.0 0.988389 arcuate nucleus of medulla, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.88017 GTEX-XMD1-0011-R9A-SM-4AT49 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12715 NANOG-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Bronchoalveolar system TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 FB-66-UU47_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.259098 CREB1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F1-26619117-HEPATOCYTES-MOUSE-LIVER ChEA Transcription Factor Targets 2022 1.0 null superficial stratum of PO1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00806 GSE135352_6_v_4_napabucasin_human RummaGEO Drug Perturbation Signatures -1.0 null 496100653_PCx_probable Alzheimer's disease_no TBI_82_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.07035 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.7344 H3K4me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SW837 CCLE Cell Line Gene Expression Profiles -1.0 -1.61934 CTCF_GM12870_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null G84 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.13063 frontal pole, right, superior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.30417 GTEX-SSA3-0008-SM-47JWJ GTEx Tissue Sample Gene Expression Profiles 1.0 1.40612 r6 part of posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13517 GTEX-XUW1-0005-SM-4BOQ7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.57823 KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.66918 RT11284 CCLE Cell Line Gene Expression Profiles -1.0 -2.07584 NCIH647 DepMap CRISPR Gene Dependency 1.0 2.60718 GSE120413,GSE120447_3_v_5_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null CREB1 ENCODE Transcription Factor Targets 1.0 null Brain TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-XOTO-0526-SM-4B662 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.72424 organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042073 H3K4me3_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-XYKS-0926-SM-4BRVG GTEx Tissue Sample Gene Expression Profiles 1.0 1.54561 periventricular stratum of r10Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08186 precentral gyrus, left, superior lateral aspect of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.01172 CEBPD_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3 Rummagene Transcription Factor Associations 2026 1.0 null ventral tuberomammillary nucleus, superficial part (histaminergic) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.4524 Lung epithelium cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.648 H3ac_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE255680_2_v_3_igf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-Q2AI-0226-SM-48U1D GTEx Tissue Sample Gene Expression Profiles 1.0 1.39173 H3K4me3_BE2C_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ZBTB7A_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 10029_ZC3H8_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.41044 ZNF263_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.903052 SUM44PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.30362 nucleus of Darkschewitsch, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.34037 USF2 ENCODE Transcription Factor Targets 1.0 null Vascular smooth muscle cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.916 anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.5973 H3K4me3_WI38_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-S7PM-0526-SM-3NM92 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.12934 caudal (posterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.47992 SP1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABPA_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XLM4-0426-SM-4AT54 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.918206 LIN9 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.50679 superficial layers of caudal presubiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.41302 EP300_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal thalamus_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.947121 Brain Lower Grade Glioma_LGG_TCGA-DB-5273-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIRT6_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1IA-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsolateral prefrontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.984812 POLR2AphosphoS5_SK-N-MC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE169571_0_v_2_dexamethasone_mouse RummaGEO Drug Perturbation Signatures 1.0 null dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.16497 Prostate adenocarcinoma_PRAD_TCGA-G9-6348-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Metabolite levels GWAS Catalog SNP-Phenotype Associations 1.0 0.793579 GTEX-S7PM-0011-R5A-SM-3NM8G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.43505 PDX1 ChEA Transcription Factor Targets 1.0 null 6555_POLR3A_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.633019 STAT3-29892750-EML-MOUSE-BONEMARROW ChEA Transcription Factor Targets 2022 1.0 null GTEX-R53T-0926-SM-3GADH GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11878 hsa-miR-4795-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.274552 TBP_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SYK_druginhibition_281_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.08757 MXI1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null superficial stratum of Mam Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4168 POLR2A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-64-5775-01A-01R-1628-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ATG2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.90126 Thap11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 30.353 NFIC_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3155b TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 NB-12-ZK38_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.273155 H3K4me3_epithelial cell of esophagus_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE164874_5_v_12_prednisolone_human RummaGEO Drug Perturbation Signatures 1.0 null 8598_SUPT5H_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.529261 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.29717 GSE148066,GSE157787_9_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null FOXP2 ENCODE Transcription Factor Targets 1.0 null GSE205976,GSE205978_3_v_0_cep83_human RummaGEO Gene Perturbation Signatures -1.0 null Kidney - Cortex GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.48828 GSE113267_0_v_1_rfx7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE119498_0_v_7_setd5_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-PLZ6-0008-SM-48TD5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.52458 negative regulation of organelle assembly GO Biological Process Annotations 2023 1.0 null H3K36me3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4QS-2126-SM-3NMCF GTEx Tissue Sample Gene Expression Profiles 1.0 0.934035 occipital pole, left, lateral aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.03176 RELB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.6359 MYOG_myocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE154577_13_v_10_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null KLF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 162.002 PMC5352183-oncotarget-08-624-s008.xlsx-Table_14-The_53_genes_whose_expression_positively_correlates_with_TP53_expression_and_which_are_located_in_cytogenetic_bands_chr17p13_11_TP53 Rummagene Transcription Factor Associations 2026 1.0 null Urinary bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 SNU-5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.55985 FASTK CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29151 hsa-miR-2467-5p TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 GTEX-QDT8-0006-SM-32PL3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.17762 Brain Lower Grade Glioma_LGG_TCGA-RY-A83Z-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PLAG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.4229 POLR2AphosphoS5_SK-N-MC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-RNOR-0826-SM-2TF5C GTEx Tissue Sample Gene Expression Profiles -1.0 -1.2321 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CALU-6 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.27328 GSE160817_0_v_8_slamf6_human RummaGEO Gene Perturbation Signatures 1.0 null POLR2A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_WI38_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null GSE202744_1_v_3_toyocamycin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_fibroblast of foreskin _hg19_1 ENCODE Histone Modification Site Profiles 1.0 null orbital frontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.56994 NR3C1_A549_hg19_7 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9753996-jci-132-160767-s182.xlsx-EBF1_associated-A1BG_EBF1 Rummagene Transcription Factor Associations 2026 1.0 null OVMANA CCLE Cell Line Gene Expression Profiles -1.0 -2.20206 POU2F2_GM12878_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null peripheral blood TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null PMC5113908-pone.0166185.s004.xlsx-Supp_1-Supplementary_Table_1_mRNA_expression_correlates_with_STAT3_phosphorylation_for_1279_genes_STAT3 Rummagene Transcription Factor Associations 2026 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N5-A4R8-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DA-35-DU85_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.379636 GSE164874_5_v_14_prednisolone_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_fibroblast of lung_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null IC-80-CT90_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.202789 GSE100316_7_v_1_mtor_mouse RummaGEO Gene Perturbation Signatures -1.0 null icSARA deltaORF6_30Hour_23365422_GSE33267 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.65401 WE-48-PP43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.96408 PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-NFKB1_mod_NFKB1 Rummagene Transcription Factor Associations 2026 1.0 null MYOG ENCODE Transcription Factor Targets 1.0 null GSE179880_7_v_5_e2f4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-V955-0005-SM-3P5ZC GTEx Tissue Sample Gene Expression Profiles 1.0 0.942061 GTEX-X585-0011-R2B-SM-46MVF GTEx Tissue Sample Gene Expression Profiles 1.0 0.94996 KDM5B ENCODE Transcription Factor Targets 1.0 null GTEX-U3ZN-0826-SM-4DXSZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.1844 SG in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.58134 PMC9745174-Table_3.xlsx-GSE8157-turquoise-ZBTB38_ZBTB38 Rummagene Transcription Factor Associations 2026 1.0 null r4 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13645 KLF5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 208.948 BATF_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-XXEK-1726-SM-4BRVB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69769 JARID1A-20064375-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE201217_4_v_6_usf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-R8-A6YH-01A-21R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Trunk TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 SREBP2-21459322-LIVER-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GOLGA4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03737 vitamin c_homo sapiens_gpl570_gse11919 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null H3K4me1_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_fibroblast of upper leg skin_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8419-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Sarcoma_SARC_TCGA-QQ-A5VC-01A-31R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE116810_2_v_0_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null NRF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null YY1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I6-01A-12R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_11955_KD_Phf23_SRP248452 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 Acute Myeloid Leukemia_LAML_TCGA-AB-2937-03A-01T-0734-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-OXRL-0008-SM-3NB29 GTEx Tissue Sample Gene Expression Profiles 1.0 1.39541 GTEX-U412-0326-SM-3DB9L GTEx Tissue Sample Gene Expression Profiles -1.0 -2.14125 PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1 Rummagene Transcription Factor Associations 2026 1.0 null polymorphic layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.05763 GTEX-T2IS-0426-SM-32QPE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.94161 CCNT2 ENCODE Transcription Factor Targets 1.0 null VEZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 88.353 H3K4me3_fibroblast of lung_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null HCFC1 ENCODE Transcription Factor Targets 1.0 null TP53-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Lymphocyte count GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.6699 Supraoptic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.00048 periventricular stratum of r6Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07861 Childhood acute myeloid leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.195 HCC827 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.14814 RCC-JW Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.01394 H3K4me3_LNCaP clone FGC_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null BATF ENCODE Transcription Factor Targets 1.0 null G112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.48135 Obesity_Adipose tissue_GSE4692 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -3.11893 FLI1_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MTA3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT549 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.69162 H3K4me3_HeLa-S3_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_H54_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZFP57 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.3754 H3K4me1_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null EP300_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-G3-A25T-01A-11R-A16W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE234043_0_v_1_abcb1_human RummaGEO Gene Perturbation Signatures 1.0 null heart TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 DC-51-WE27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.97518 GTEX-X585-2426-SM-46MW2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.52537 cortico-medial group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.898086 POLR2AphosphoS5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_14084_KD_FGF13_SRP114701 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 6.88581 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5881-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_2-ETS1_high-signal_selected_bound_promoters_ETS1 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6793-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null NR2F2 ENCODE Transcription Factor Targets 1.0 null BT-20 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.9823 CCM2L CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.16939 H3K4me3_CD14-positive monocyte_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PU.1-20513432-BCELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC11699082-BLOODA_ADV-2023-012291-mmc1.xlsx-Sheet1-CD37_pos_corr_top100_GSE10846_CHOP_GCB_DDIT3 Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4725-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.541706 CLDN11 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.60467 OCIAML3 Achilles Cell Line Gene Essentiality Profiles 1.0 1.64937 POU5F1-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null WHSC1 ENCODE Transcription Factor Targets 1.0 null dorsolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.69615 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF_BJ_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BT-549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09298 U2OS DepMap CRISPR Gene Dependency 1.0 2.77559 SRF_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMR6-0011-R1A-SM-32PKW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08458 GTEX-PLZ5-0006-SM-2S1NZ GTEx Tissue Sample Gene Expression Profiles 1.0 3.99194 Alimentary canal TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-XOTO-2126-SM-4B64U GTEx Tissue Sample Gene Expression Profiles 1.0 1.18739 GSE183041_1_v_0_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null 6288_PHF23_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.555328 cell part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 CEBPD ENCODE Transcription Factor Targets 1.0 null ZIC1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 58.8168 Zinc finger, PHD-finger InterPro Predicted Protein Domain Annotations 1.0 null GSE68156_3_v_5_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null SIX5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rt4 HPA Cell Line Gene Expression Profiles -1.0 -0.91051 BRAP CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05865 Mesothelioma_MESO_TCGA-NQ-A57I-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CTCF_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149901_2_v_1_anlotinib_human RummaGEO Drug Perturbation Signatures 1.0 null GSE158834_12_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null STAT1 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-V955-0726-SM-3GAFG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18846 GSE203181_0_v_1_phosphoramidon_human RummaGEO Drug Perturbation Signatures -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A9PE-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A45Q-01A-11R-A24H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r10 part of gigantocellular reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31163 GSE179974_3_v_2_carboplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-WFG7-0005-SM-3GIKM GTEx Tissue Sample Gene Expression Profiles 1.0 1.1396 Prostate adenocarcinoma_PRAD_TCGA-XQ-A8TB-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null ME-31-RM40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.650307 integument TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE217776,GSE217829_4_v_6_sgf29_human RummaGEO Gene Perturbation Signatures 1.0 null ZNF454 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 120.923 Lung adenocarcinoma_LUAD_TCGA-49-4494-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XLM4-0004-SM-4AT5I GTEx Tissue Sample Gene Expression Profiles 1.0 0.838108 ATF2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null amygdaloid complex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.37505 FOXP1 ChEA Transcription Factor Targets 1.0 null GSE148066,GSE157787_11_v_6_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null internal granular layer of CbVCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.15223 MLL1/2 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.578 TCF12_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OCIP5X DepMap CRISPR Gene Dependency 1.0 2.49709 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70A-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE131649_6_v_7_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null Peripheral T-cell lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.029 NCI-H2291 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.95081 mantle zone of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22407 chromatin COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.203022 GSE142210_11_v_1_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.25733 H3K4me3_cardiac mesoderm_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null NR1I2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.8237 IGROV-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null ELK1 ChEA Transcription Factor Targets 1.0 null hsa-miR-548d-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.199275 TPM3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07899 GSE201217_3_v_6_usf2_mouse RummaGEO Gene Perturbation Signatures 1.0 null EP300_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01808 GATA1 ENCODE Transcription Factor Targets 1.0 null Postpiriform transition area, layers 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12054 Hoxd13 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 18.3152 GSE152699,GSE152723_0_v_1_vemurafenib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-O5YT-2126-SM-3MJGD GTEx Tissue Sample Gene Expression Profiles 1.0 1.96228 H3K4me3_K562_hg19_4 ENCODE Histone Modification Site Profiles 1.0 null LC1SQSF CCLE Cell Line Gene CNV Profiles -1.0 -1.83838 Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12764 B-cell acute lymphoblastic leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.279 SW 620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.555 YMB-1-E Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16717 GSE174498,GSE174500_3_v_4_asparaginase_human RummaGEO Drug Perturbation Signatures 1.0 null amygdaloid complex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.89684 Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9GY-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null A704_KIDNEY CCLE Cell Line Proteomics 1.0 2.93335 MAFK JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.9469 MS (Multiple Sclerosis)_CNS - Spinal Cord (MMHCC)_GSE842 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.81467 thyroid_5c HPA Tissue Sample Gene Expression Profiles 1.0 1.01786 Uterus GTEx Tissue Gene Expression Profiles 2023 -1.0 -1.80678 GSE152432_1_v_4_zrsr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QMRM-0005-SM-3NB2A GTEx Tissue Sample Gene Expression Profiles 1.0 1.06618 disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.164359 SP4 ENCODE Transcription Factor Targets 1.0 null KLF11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 93.0109 GSE142684_3_v_5_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE169205_3_v_6_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null H2AFZ_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K9ac_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EBF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletalmuscle_c HPA Tissue Sample Gene Expression Profiles -1.0 -1.18323 MAX_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4739 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 bonemarrow_6a HPA Tissue Sample Gene Expression Profiles -1.0 -1.68099 upper (rostral) rhombic lip_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.52103 myeloid leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.900335 Skin Cutaneous Melanoma_SKCM_TCGA-D9-A3Z3-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in caudal hippocampal proper Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.48268 H3K36me3_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1 ChEA Transcription Factor Targets 1.0 null intracellular COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 ELF1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAPAN-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.871542 Lymphatic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.315 H3K4me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A410-01A-11R-A32Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE140651,GSE140653_2_v_1_med1_human RummaGEO Gene Perturbation Signatures 1.0 null 496100436_FWM_no dementia_no TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.26108 GSE142210_3_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null A375 CCLE Cell Line Gene Expression Profiles 1.0 1.62011 PLAGL2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 77.6301 H3K4me3_cardiac fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null spinal trigeminal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17078 GSE158834_2_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_CH12.LX_mm9_5 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Perturb_1153_KD_EZH2_SRP021509 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 8.21694 orbital frontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.52134 VD-88-MW70_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.03334 GTEX-QVJO-0008-SM-447AU GTEx Tissue Sample Gene Expression Profiles 1.0 1.14273 GTEX-XUZC-0226-SM-4BOO7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.15678 PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-Unnamed_0_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_SK-N-SH_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-3A-A9I5-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A763-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CF-91-JY05_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.274568 GSE227592_8_v_3_adar_human RummaGEO Gene Perturbation Signatures 1.0 null COV362 Achilles Cell Line Gene Essentiality Profiles -1.0 -2.04646 GTEX-WRHK-0005-SM-3MJF5 GTEx Tissue Sample Gene Expression Profiles 1.0 0.940324 Fetal Death CTD Gene-Disease Associations 1.0 1.07093 H3K27ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-3929 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 POLR2AphosphoS5_Panc1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE110178_5_v_3_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null GSE120612_7_v_2_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null Aorta thoracica smooth muscle cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.941 r3 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01333 GSE165647_5_v_3_cry2_mouse RummaGEO Gene Perturbation Signatures 1.0 null AML193 CCLE Cell Line Gene CNV Profiles -1.0 -1.38241 CHD2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5700-01A-11R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of autophagosome maturation GO Biological Process Annotations 2023 1.0 null TE15 CCLE Cell Line Gene CNV Profiles 1.0 1.4659 H3K4me2_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KA-29-AB08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.71132 ELF1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null OVMANA Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.43359 Placenta BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.826336 Autoimmune disease of endocrine system DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.601 GTEX-XQ3S-0008-SM-4GIDZ GTEx Tissue Sample Gene Expression Profiles 1.0 0.883142 PRR13 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.04042 Inferior colliculus, dorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.74238 SKMEL3 CCLE Cell Line Gene Expression Profiles 1.0 1.36191 ChIP_KLF4_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null GSE171572_3_v_4_tp53_human RummaGEO Gene Perturbation Signatures -1.0 null Rectum adenocarcinoma_READ_TCGA-G5-6572-02A-12R-1830-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null positive regulation of protein ubiquitination GO Biological Process Annotations 2025 1.0 null GSE153064,GSE153065_1_v_0_hdac3_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-RVPU-0011-R7A-SM-2XCAB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.35433 8599_SUPT6H_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.822101 RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.90261 Rectum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26523 Artery - Tibial GTEx Tissue Gene Expression Profiles 2023 -1.0 -0.611922 H3K4me3_bronchial epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null RFX5_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-5525-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null MAX_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_7232_KO_ADIPOR2_SRP285935 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -2.8315 E2F4 ChEA Transcription Factor Targets 1.0 null PMC11655728-12672_2024_1562_MOESM2_ESM.xlsx-Sheet1-Hs_ESC_SOX2_targets_Boyer_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null MZ in dorsomedial parietal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.999518 PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_filtered-genes_ESR1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-T5JC-0626-SM-3NMA6 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.43738 GSE179693,GSE179694_4_v_2_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null ZKSCAN1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null pleural fluid TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.454898 GSE116810_5_v_0_selinexor_human RummaGEO Drug Perturbation Signatures 1.0 null SIN3A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null digestive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE142210_9_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTF2F1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SkeletalMuscle BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.22702 GTEX-SIU8-0826-SM-2XCDQ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.990729 intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE213588_10_v_13_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GABPA_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 16207381-Table1Sa GeneSigDB Published Gene Signatures 1.0 null FGFR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.82233 ChIP_H3K36me3_18692474_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null r9 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91507 pleura TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.199146 orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.876854 H3K4me3_Caco-2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE196343_1_v_0_metformin_human RummaGEO Drug Perturbation Signatures 1.0 null posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.21064 PML_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PP-1026-SM-3NM9O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.58326 H3K4me3_Panc1_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE171712_0_v_1_scgb1a1_mouse RummaGEO Gene Perturbation Signatures -1.0 null NCI-H2595 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18477 periventricular stratum of r9Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08186 TCF3 ChEA Transcription Factor Targets 1.0 null EP300_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIN3A_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KLF15 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 96.7542 GSE168401_1_v_0_harmine_human RummaGEO Drug Perturbation Signatures -1.0 null terete nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.0717 GSE121866_0_v_2_six4_human RummaGEO Gene Perturbation Signatures -1.0 null HDAC2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null THAP11-20581084-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD4-27068464-CHIP-SEQ-AML-CELLS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null septal nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.29989 Infertility, Female CTD Gene-Disease Associations 1.0 1.06333 FD-91-OK66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.09038 viscus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MBD4_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null VZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.925003 GTEX-PW2O-0008-SM-48TEB GTEx Tissue Sample Gene Expression Profiles 1.0 0.838834 Prostate BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.86225 KARPAS1718 DepMap CRISPR Gene Dependency 1.0 2.14427 SNUC1_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 4.56498 intermediate stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28027 ZBTB7A_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMR6-0011-R7A-SM-32PKL GTEx Tissue Sample Gene Expression Profiles -1.0 -1.56622 GSE179880_2_v_5_e2f4_mouse RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-548aj TargetScan Predicted Conserved microRNA Targets 1.0 0.226173 YA-78-MS95_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.951349 PHGDH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28074 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70O-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null GSE120612_6_v_3_etoposide_human RummaGEO Drug Perturbation Signatures 1.0 null Hypothyroidism DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.48 H3K9ac_NT2-D1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PACADD161 DepMap CRISPR Gene Dependency 1.0 2.21508 H3K4me3_Jurkat_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null amygdalohippocampal transition zone, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.0503 GSE135439_0_v_1_pax5_human RummaGEO Gene Perturbation Signatures 1.0 null CHD2 ENCODE Transcription Factor Targets 1.0 null GSE154577_2_v_12_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null GSE153871_4_v_3_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.22855 PMC12019518-ao5c02459_si_002.xlsx-Table_S3-Table_S3_Screening_of_genes_that_are_commonly_upregulated_in_cells_on_stiff_substrate_and_down-regulated_by_KD_of_UBE2A_B_AR Rummagene Transcription Factor Associations 2026 1.0 null NCIH2452 CCLE Cell Line Gene CNV Profiles 1.0 1.52151 EOMES-21245162-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null ATF3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DA-20-VR86_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.450093 GTEX-XUW1-1726-SM-4BOOZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6696 GTEX-SNOS-0926-SM-4DM7A GTEx Tissue Sample Gene Expression Profiles -1.0 -0.873959 ELF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PLZ5-1526-SM-3P5ZX GTEx Tissue Sample Gene Expression Profiles 1.0 0.921644 THP1 CCLE Cell Line Gene CNV Profiles -1.0 -1.70564 NELFE_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7608_RUVBL2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.610266 ATF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE199255,GSE199356_6_v_2_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null PML_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S33H-1326-SM-4AD6A GTEx Tissue Sample Gene Expression Profiles 1.0 0.84215 GTEX-OOBK-1626-SM-2HMKG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.895216 GSE158834_0_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Bone structure disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.082 FLI1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13457 intermediate stratum of r9Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.10823 H3K27ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null IC-05-AW29_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.231343 Acute erythroid leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.113 JUND_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null claustrum, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.849157 SIN3A_H1-hESC_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SMAD2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6075 D283MED CCLE Cell Line Gene CNV Profiles -1.0 -1.32949 SCNN1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.07027 H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PU.1-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Uterine cervix TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 UTP14C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14641 GSE102269_3_v_0_clpp_mouse RummaGEO Gene Perturbation Signatures -1.0 null CDK4_knockdown_143_GSE31912 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.0704 SP4_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 7527_RPS5_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.674228 Lobule III Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11328 cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12358 NCI-H650 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.903052 GTEX-P4QS-0926-SM-48TBS GTEx Tissue Sample Gene Expression Profiles 1.0 0.877653 CTBP2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLRX3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.35332 NCIH522 CCLE Cell Line Gene CNV Profiles -1.0 -2.34165 Peripheral_Blood_Mononuclear_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.06004 GLIS2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 89.3388 GSE225735_0_v_4_aldosterone_human RummaGEO Drug Perturbation Signatures -1.0 null SNU761 DepMap CRISPR Gene Dependency 1.0 2.19409 GTEX-O5YT-1626-SM-32PK6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24694 CTCF_epithelial cell of esophagus_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null USF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.916228 Viscus TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 superficial stratum of POH Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.75125 H3K79me2_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2342 COSMIC Cell Line Gene Mutation Profiles 1.0 null DA-85-SU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.444623 SLC35B4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34422 ARNT2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.13328 POLR2A_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Type 2 diabetes mellitus_Renal Tissue_GSE642 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.51354 FLI1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.4864 MYC_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDT8-0011-R4A-SM-32PKM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.846778 GTEX-O5YT-0926-SM-48TDG GTEx Tissue Sample Gene Expression Profiles 1.0 0.976134 inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2717 MAZ_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12885 dorsolateral preisthmic part of periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55057 GTEX-QXCU-0626-SM-2TC69 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.87554 Mature T-cell and NK-cell lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.025 GTEX-T8EM-0326-SM-3DB7F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.920207 CENPE CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1632 POLR2A_endothelial cell of umbilical vein_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCT-116 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE158834_7_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null YY1_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RTLS-0008-SM-48FET GTEx Tissue Sample Gene Expression Profiles 1.0 0.857452 GTEX-SJXC-0008-SM-4DM7G GTEx Tissue Sample Gene Expression Profiles 1.0 1.06923 ZBTB11 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.7006 1083_NEPRO_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 1.00025 H3K4me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null KDM5B_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null skeletalmuscle_d HPA Tissue Sample Gene Expression Profiles -1.0 -1.66521 BC-54-ON71_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.457794 POLR2A_olfactory bulb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SNU-407 COSMIC Cell Line Gene Mutation Profiles 1.0 null outer SZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.8719 Sarcoma_SARC_TCGA-X6-A8C4-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BC-11-LL59_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.272898 NCI-H2369 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.859707 OVK18 CCLE Cell Line Gene Expression Profiles 1.0 1.50982 H3K4me3_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ATF2 ENCODE Transcription Factor Targets 1.0 null H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null r3 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.9708 Primary hematopoietic stem cells G-CSF-mobilized Female RO_01480 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.53177 POLR2A_HeLa-S3_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE220520_6_v_0_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null SUSA DepMap CRISPR Gene Dependency 1.0 2.63372 GSE228181_4_v_1_idh1_mouse RummaGEO Gene Perturbation Signatures 1.0 null soft tissue HPA Tissue Protein Expression Profiles -1.0 -1.90368 1578_CHML_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.529391 MSANTD2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22744 MRPL19 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.57624 inferolateral temporal cortex (area TEv, area 20)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.07564 USF1 MotifMap Predicted Transcription Factor Targets 1.0 null GSE228106_0_v_4_paclitaxel_human RummaGEO Drug Perturbation Signatures 1.0 null T-cell non-Hodgkin lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.395 POU5F1 ChEA Transcription Factor Targets 1.0 null supraoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10894 SF295 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.44741 GTEX-V1D1-0726-SM-4JBH7 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.951116 head TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE144115_1_v_3_stag2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CD-05-PU90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.64905 GATA4_INACTIVATION_GDS3663_519_mouse_Endothelial-derived cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null hypoglossal nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06554 STK33_knockdown_50_GSE15151 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.62436 GSE195663_7_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158834_0_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null H3K36me3_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EGR1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U412-0008-SM-4DXTE GTEx Tissue Sample Gene Expression Profiles 1.0 0.842733 CBX3_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA-75-HA22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.86125 SNU-484 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.16427 EP300 ENCODE Transcription Factor Targets 1.0 null USF1_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null BA-84-WN26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.51687 9686_UTP3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.925107 IKZF1 ENCODE Transcription Factor Targets 1.0 null GTEX-X3Y1-0426-SM-3P5Z4 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.827415 Lobule II, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41542 C-33 A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.34714 HCT-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE146982_0_v_1_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CEBPB_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EWSR1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.0917 SPI1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE149035_7_v_0_hepacam_human RummaGEO Gene Perturbation Signatures -1.0 null EP300_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE195582_0_v_1_pim1_mouse RummaGEO Gene Perturbation Signatures -1.0 null 9684_UTP20_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.520721 Lymphoid leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.503 MALME3M CCLE Cell Line Gene Expression Profiles 1.0 2.06317 r9 part of nucleus gracilis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39735 H3K4me3_cardiac fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null gastrointestinal tract TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GABPA_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBP-23326641-C3H10T1-2-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-S3XE-0006-SM-3K2AA GTEx Tissue Sample Gene Expression Profiles 1.0 0.915027 Acute promyelocytic leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.22 GSE207135_1_v_0_sod2_human RummaGEO Gene Perturbation Signatures -1.0 null POLR2A_GM18526_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DC-51-WE27_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.9864 periventricular stratum of r2BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.26245 H3K4me3_fibroblast of gingiva_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Hematopoietic system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.35 H4K20me1_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.72359 PMC12178384-mmc4.xlsx-Sheet1-Supp_Table_2_Differential_expression_analysis_of_CIC-rearranged_sarcomas_vs_BCOR-rearranged_sarcomas_CIC Rummagene Transcription Factor Associations 2026 1.0 null CTCF_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE207282_1_v_0_polydatin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SN8G-0126-SM-32PLI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.41374 GTEX-SNMC-0126-SM-2XCFO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20939 GSE186810,GSE186813_7_v_5_furin_mouse RummaGEO Gene Perturbation Signatures -1.0 null Intervertebral disc TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.881 ZBTB33_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAOV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.83508 GTEX-SNMC-0006-SM-2XCFE GTEx Tissue Sample Gene Expression Profiles 1.0 1.48454 GTEX-PWN1-2426-SM-48TDD GTEx Tissue Sample Gene Expression Profiles 1.0 0.864307 YY1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null cerebral hemisphere TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GTEX-X4XY-0626-SM-4E3IN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.883709 Prostate adenocarcinoma_PRAD_TCGA-G9-6332-01A-11R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE186483_2_v_0_lrrk2_mouse RummaGEO Gene Perturbation Signatures 1.0 null KURAMOCHI Achilles Cell Line Gene Essentiality Profiles -1.0 -2.95222 H3K27ac_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r5 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72965 GSE213588_8_v_4_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null BT12 DepMap CRISPR Gene Dependency 1.0 2.52038 SFPI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_downreg-human_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Myeloid progenitor cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.199 Accessory olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.24875 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.946098 Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3SM-01A-11R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SN8G-0326-SM-32PLG GTEx Tissue Sample Gene Expression Profiles -1.0 -1.5013 PMC8764619-mmc7.xlsx-supplementary_table_for_the_Ven-Ale_DE_MSC_genes_H_sapiens_340_MSC Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_NB4_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-PVOW-0008-SM-48TE8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.48408 NELFE ENCODE Transcription Factor Targets 1.0 null CTCF_fibroblast of villous mesenchyme_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null YY1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12178384-mmc5.xlsx-Sheet1-Supp_Table_3_Differential_expression_analysis_of_CIC-rearranged_sarcomas_vs_Ewing_sarcomas_CIC Rummagene Transcription Factor Associations 2026 1.0 null POLR2A_MEL cell line_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100549_FWM_no dementia_TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.40645 H3K27ac_bone marrow macrophage_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null arcuate nucleus of hypothalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14736 cuneate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.43626 TAF1_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135352_0_v_3_napabucasin_human RummaGEO Drug Perturbation Signatures -1.0 null GSE158834_0_v_4_palm_human RummaGEO Gene Perturbation Signatures -1.0 null Zinc finger, PHD-type InterPro Predicted Protein Domain Annotations 1.0 null dorsal lateral geniculate nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.03336 GTEX-UJMC-0226-SM-4IHLH GTEx Tissue Sample Gene Expression Profiles 1.0 1.5775 MS (Multiple Sclerosis)_B Cell Lymphocyte_GSE10064 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.0813 Cortical amygdalar area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12472 layer VI of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1557 Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null transient Purkinje cell clusters Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.89223 FOXP1-21924763-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null cerebral cortex TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 POLR2A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50346 JIYOYE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.01227 POLR2A_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_Raji_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me3_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Folium-tuber vermis (VII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91777 LN-18 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.92642 Spi1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 70.9337 PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_DN_AA_DN-AA_DN_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null TAF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-7671-01A-11R-2066-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null myeloblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.844965 JUND ENCODE Transcription Factor Targets 1.0 null GTEX-QEG4-0008-SM-48TYZ GTEx Tissue Sample Gene Expression Profiles 1.0 1.3555 GSE149264,GSE149267_4_v_5_trp53_mouse RummaGEO Gene Perturbation Signatures -1.0 null YY1_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_4 mos_M_12889 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.46604 YY1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null head TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 PMC8384902-mmc2.xlsx-5_POU2F3_high_subtype-Gene_Symbol_POU2F3 Rummagene Transcription Factor Associations 2026 1.0 null SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.15892 POLR2A_A549_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE169571_3_v_4_dexamethasone_mouse RummaGEO Drug Perturbation Signatures -1.0 null SCC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.74479 HS 746T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.938239 r6 part of nucleus prepositus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33445 ELK4 JASPAR Predicted Transcription Factor Targets 1.0 null NCI-H1793 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.917511 GTEX-WRHU-0826-SM-3MJFN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.02384 C2BBE1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.17675 H3K4me3_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NANOG ChEA Transcription Factor Targets 1.0 null COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.71691 PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_3_GSC Rummagene Transcription Factor Associations 2026 1.0 null SIN3A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ribavirin_homo sapiens_gpl570_gds4391 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null 308_ANAPC4_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.608501 SNU1079 CCLE Cell Line Gene CNV Profiles 1.0 1.4819 FOS_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 2291_DNAJC17_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.52375 GTEX-S4Q7-0226-SM-4AD5O GTEx Tissue Sample Gene Expression Profiles 1.0 0.981659 HL60 Achilles Cell Line Gene Essentiality Profiles 1.0 1.42882 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.1251 WT1 ChEA Transcription Factor Targets 1.0 null Fastigial nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6704 UACC-257 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.69483 HCC364 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.99884 SNU738 CCLE Cell Line Gene CNV Profiles 1.0 2.05824 H3K4me1_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-52-7811-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE85880,GSE85881_0_v_1_tretinoin_human RummaGEO Drug Perturbation Signatures 1.0 null GSE129287_0_v_1_cd200_mouse RummaGEO Gene Perturbation Signatures 1.0 null KLHL21 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28484 superficial stratum of r5Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02711 posteroventral (inferior) parietal cortex_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.55417 GTEX-RNOR-0526-SM-2TF4O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.79648 bed nucleus of stria terminalis Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.90062 GSE226285_3_v_0_glutathione_human RummaGEO Drug Perturbation Signatures -1.0 null GATA3-21867929-TH1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null KCL22 CCLE Cell Line Gene CNV Profiles -1.0 -1.89641 GSE231648_0_v_2_lsm14b_mouse RummaGEO Gene Perturbation Signatures 1.0 null posteroventral (inferior) parietal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.16729 GTEX-PX3G-0326-SM-2I3EO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.917613 cerebellar cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.22819 EP300_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE214505_0_v_1_akr1b1_human RummaGEO Gene Perturbation Signatures 1.0 null JC-06-ED36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.428741 AC-35-CK01_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.334143 COLO679 DepMap CRISPR Gene Dependency 1.0 3.61435 medial habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.950602 PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK4_all_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null 10623_ZNF774_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures -1.0 -0.648376 NCIH1792 CCLE Cell Line Gene CNV Profiles -1.0 -1.43201 CB-31-UO16_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.10145 GTEX-T2YK-0005-SM-32QOV GTEx Tissue Sample Gene Expression Profiles 1.0 1.83614 H3K36me3_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE219274,GSE219276_3_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null Thymus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.54838 H3K36me3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE146253_0_v_5_stat4_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-V1D1-0006-SM-3NMCE GTEx Tissue Sample Gene Expression Profiles 1.0 1.02863 MAX_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE152055_2_v_3_mpc1_mouse RummaGEO Gene Perturbation Signatures 1.0 null QE-79-XO29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.356655 ZNF610 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 81.4082 MAFA MotifMap Predicted Transcription Factor Targets 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Congenital myasthenic syndrome 5 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.475 GSE133329_2_v_3_trim28_human RummaGEO Gene Perturbation Signatures -1.0 null GSE142210_4_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XBEW-0006-SM-4AT4E GTEx Tissue Sample Gene Expression Profiles 1.0 1.00995 COGE352 DepMap CRISPR Gene Dependency 1.0 2.12186 metal ion binding GO Molecular Function Annotations 2015 1.0 null PMC6484770-41388_2018_602_MOESM5_ESM.xlsx-down_P53_vs_con-Unnamed_1_TP53 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-WZTO-0826-SM-3NM8Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.54878 GSE147876,GSE147877_4_v_7_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null Bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K4me1_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null MET_knockout_248_GDS3148 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.72547 GSE148066,GSE157787_0_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null TOV-112D Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.92273 PANC0813 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.07264 GSE137144_4_v_6_nlrp3_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE195582_2_v_1_pim1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_WERI-Rb-1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null organelle LOCATE Predicted Protein Localization Annotations 1.0 null EE-03-SG02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232211 Cortical amygdalar area, posterior part, medial zone, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11469 KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H3K27ac_Duodenum Smooth Muscle Roadmap Epigenomics Histone Modification Site Profiles 1.0 null GTEX-UPIC-0726-SM-3GADW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07972 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19K-01A-21R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Charcot-Marie-Tooth disease axonal type 2T DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.153 MAX_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A59T-01A-21R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H4K20me1_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H820 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.859759 FB-32-PY27_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.410889 CHD-type complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.256 YY1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DB-54-GQ68_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -7.7341 GSE203158_0_v_13_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null SPI1_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.01753 GSE57871_6_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null CEBPA-20513432-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 WM793 DepMap CRISPR Gene Dependency 1.0 2.10184 JE-72-KV75_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.08038 H3K9ac_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Hand TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.019 NFIC_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null THP-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.15145 ETS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.6663 ZNF143 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5352 GSE110178_1_v_7_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null SARS-BatSRBD_72Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.71167 MYC_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QMRM-0008-SM-447B1 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12357 hippocampus (hippocampal formation)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.72577 HCoV-EMC2012_24Hour_23631916_GSE45042 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.60271 SPI1 ChEA Transcription Factor Targets 1.0 null STAT5A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PACADD165 DepMap CRISPR Gene Dependency 1.0 2.32334 GTEX-R45C-0008-SM-48FF2 GTEx Tissue Sample Gene Expression Profiles 1.0 1.13511 GTEX-WFG8-0626-SM-3GILJ GTEx Tissue Sample Gene Expression Profiles -1.0 -0.879139 Lung squamous cell carcinoma_LUSC_TCGA-21-A5DI-01A-31R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158834_11_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null Duodenum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.069 SPI1-22790984-ERYTHROLEUKEMIA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_kidney epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE196699_7_v_3_prdm16_mouse RummaGEO Gene Perturbation Signatures -1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Gall bladder TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K4me3_MEL cell line_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null transition metal ion binding GO Molecular Function Annotations 2015 1.0 null POLR2AphosphoS5_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_GM12866_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null EC-96-KI84_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.381123 orbital frontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.05157 amygdaloid complex_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.65123 496100577_FWM_probable Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.7514 MAX_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SW948_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 3.75411 H3K4me3_fibroblast of pedal digit skin_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null urinarybladder_5c HPA Tissue Sample Gene Expression Profiles 1.0 0.990441 Thymic Carcinoma_Thymus_GSE2501 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.59222 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I0-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EC-62-OE64_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.12513 GSE201239_6_v_1_fmr1_mouse RummaGEO Gene Perturbation Signatures -1.0 null IF-87-AU84_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.471 AMOTL2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.08884 Lung adenocarcinoma_LUAD_TCGA-44-4112-01A-01R-1107-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE228181_4_v_5_idh1_mouse RummaGEO Gene Perturbation Signatures 1.0 null UTY CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.38465 periventricular stratum of r3Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07861 r9 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44769 H3K36me3_bronchial epithelial cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null pancreas HPA Tissue Gene Expression Profiles -1.0 -0.952407 MYOG_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO 678 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.96664 NCI-H2009 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.37185 GTEX-TMMY-0126-SM-4DXTP GTEx Tissue Sample Gene Expression Profiles 1.0 1.82605 TAF1_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Arsenic CTD Gene-Chemical Interactions 1.0 null ED-05-LQ40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.19401 GSE158834_12_v_4_palm_human RummaGEO Gene Perturbation Signatures -1.0 null TBP_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_skeletal muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null ETS1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4PQ-1026-SM-3NMCN GTEx Tissue Sample Gene Expression Profiles -1.0 -2.39568 liver BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -2.04767 EZH2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE189789_0_v_1_oridonin_human RummaGEO Drug Perturbation Signatures 1.0 null H3K9ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r4 liminal central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02494 PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_14_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null H3K36me3_CH12.LX_mm9_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null Small intestine TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.069 GSE171401_1_v_0_adnp_human RummaGEO Gene Perturbation Signatures 1.0 null Chondrocyte cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.876 AP1S2 ChEA Transcription Factor Targets 1.0 null UBTF_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.655 H3K4me3_GM12878_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE235701,GSE261434_0_v_1_enasidenib_human RummaGEO Drug Perturbation Signatures -1.0 null Weight Loss CTD Gene-Disease Associations 1.0 1.15865 skeletal system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.056987 hsa-miR-549 TargetScan Predicted Conserved microRNA Targets 1.0 0.361556 FLI1_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA2_SH-SY5Y_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CA-68-KG29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.658949 GSE180789_1_v_0_hnrnpc_human RummaGEO Gene Perturbation Signatures 1.0 null EP300_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-86-8672-01A-21R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-VUSG-0006-SM-3GIK9 GTEx Tissue Sample Gene Expression Profiles 1.0 2.36364 GTEX-WYVS-2326-SM-3NMAI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42321 Liver BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.69706 GSE203158_0_v_8_aire_mouse RummaGEO Gene Perturbation Signatures 1.0 null AA-86-YY62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.445294 Lung squamous cell carcinoma_LUSC_TCGA-56-7730-01A-11R-2125-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LHB CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.29919 ELF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Finger TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 2.019 GTEX-PLZ6-1526-SM-2S1OC GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3173 PA-75-VL17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.627692 18032706-SuppTable3 GeneSigDB Published Gene Signatures 1.0 null p2 portion of the substantia nigra pars reticulata Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11552 POLR2A_HepG2_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.32178 GSE184356_3_v_0_tfam_human RummaGEO Gene Perturbation Signatures -1.0 null Ileocecum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 Sarcoma_SARC_TCGA-FX-A8OO-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r10 part of nucleus gracilis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11263 GSE171724_4_v_6_ezh2_mouse RummaGEO Gene Perturbation Signatures -1.0 null KB-92-MK13_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.266646 Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5SF-01A-11R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RELA_GM15510_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S95S-0005-SM-2XCEC GTEx Tissue Sample Gene Expression Profiles 1.0 0.982035 Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AE-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_GM12864_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Targets 2022 1.0 null r5 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37216 POU5F1-18347094-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TA-34-CK62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.84963 POLR2A_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EOMES-21245162-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Spinal cord TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.705 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null tonsil_8b1 HPA Tissue Sample Gene Expression Profiles 1.0 1.13016 G-361 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.993496 periventricular stratum of r5Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01823 Corpus callosum TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.988 MYC ENCODE Transcription Factor Targets 1.0 null GTEX-RTLS-0826-SM-2TF5Q GTEx Tissue Sample Gene Expression Profiles -1.0 -0.836741 GSE226114,GSE226116_2_v_0_doxorubicin_mouse RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_HepG2_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Origin recognition complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.759 GSE186483_6_v_4_lrrk2_mouse RummaGEO Gene Perturbation Signatures -1.0 null posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.892223 GTEX-WCDI-0008-SM-47JYE GTEx Tissue Sample Gene Expression Profiles 1.0 1.19597 periventricular stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.911 Folium-tuber vermis (VII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.07435 Lung squamous cell carcinoma_LUSC_TCGA-39-5011-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE168798_0_v_1_isg15_human RummaGEO Gene Perturbation Signatures 1.0 null GSE142210_3_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-LB-A8F3-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XPVG-0326-SM-4B653 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17863 Nucleus of the lateral olfactory tract, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.15912 H3K79me2_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE103068_5_v_7_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null YY1 ENCODE Transcription Factor Targets 1.0 null GSE227127_1_v_0_diclofenac_human RummaGEO Drug Perturbation Signatures -1.0 null QA-07-KC40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.217507 RORA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.3764 striatum_19 yrs_F_12832 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.46338 large intestine TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null lateral orbital frontal cortex (area 12/47) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.833481 MDA-MB-435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03606 ZNF135 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 152.774 YY1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KYM-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 1.97338 GSE57871_11_v_12_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K36me3_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lobule III, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14679 H3K4me3_fibroblast of foreskin _hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE146982_0_v_1_metformin_human RummaGEO Drug Perturbation Signatures -1.0 null lateral tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51171 Lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.344 GTEX-PLZ4-0006-SM-2S1NY GTEx Tissue Sample Gene Expression Profiles 1.0 1.5278 Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SRF_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r7 part of cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.7768 inferolateral temporal cortex (area TEv, area 20)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -3.31964 POU2F2 JASPAR Predicted Transcription Factor Targets 1.0 null TCF12 ENCODE Transcription Factor Targets 1.0 null internal female genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SIX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null heart GTEx Tissue Gene Expression Profiles -1.0 -1.0498 hl60 HPA Cell Line Gene Expression Profiles -1.0 -0.880358 ND-39-PO34_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.386576 H3K36me3_osteoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPT6-0126-SM-4B65S GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37613 NELFE_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-1276 TargetScan Predicted Conserved microRNA Targets 1.0 0.404082 Declive (VI), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65833 SPI1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NF-01A-11R-A27V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETV2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7781 gracile nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.60719 ZNF263_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 496100539_HIP_probable Alzheimer's disease_TBI_78_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.08898 Inflammation CTD Gene-Disease Associations 1.0 1.23616 GSE162892_4_v_2_isox_human RummaGEO Drug Perturbation Signatures -1.0 null EZH2_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE244072_4_v_6_tfeb_mouse RummaGEO Gene Perturbation Signatures 1.0 null EZH2_keratinocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-SUCS-1426-SM-4DM5W GTEx Tissue Sample Gene Expression Profiles -1.0 -1.27761 8903_TIAL1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.527454 MDAMB436 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.02055 CRX-20693478-ADULT_RETINA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.00304 CTCF_T47D_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC827 DepMap CRISPR Gene Dependency 1.0 3.78233 GSE184884_4_v_1_gps2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Heart - Left Ventricle GTEx Tissue Gene Expression Profiles 2023 1.0 2.94335 MYC_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.14644 FLI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE57871_11_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null polysensory temporal cortex (area 22p) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.88902 H4K20me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Poisoning CTD Gene-Disease Associations 1.0 1.23899 A-498 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00655 ABCA3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05977 PMC6126969-NIHMS979612-supplement-7.xlsx-Tab_4_Overlap_of_ERM_proteom-Gene_Name_ETV5 Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.079255 GTEX-PWOO-0006-SM-2I3E3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.07232 GTEX-WHPG-2226-SM-3NMBO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.910392 ME-31-RM40_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.214351 BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.550926 PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null STAT4-19710469-TH1 cell mouse-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null PMC12586162-41593_2025_2050_MOESM3_ESM.xlsx-Supplementary_Table_7-ELK4_all_ELK4 Rummagene Transcription Factor Associations 2026 1.0 null TCF7L2 ENCODE Transcription Factor Targets 1.0 null OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.86787 NCI-H1770 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.50522 H3K4me3_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_7A-MAX_WT_TESTES_MAX Rummagene Transcription Factor Associations 2026 1.0 null POLR2AphosphoS5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7SF-0008-SM-3NM8T GTEx Tissue Sample Gene Expression Profiles 1.0 1.11386 PAQR8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1378 GSK3B_knockdown_209_GSE35351 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.37612 GATA1_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GB-46-CK08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.01993 RAP1GAP2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.34334 GTEX-QVUS-0226-SM-3GIJY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95982 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5LG-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIN3A_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07011 M040416 DepMap CRISPR Gene Dependency 1.0 2.38064 DA-20-VR86_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.571688 CIART CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.16601 BV173 CCLE Cell Line Gene Expression Profiles -1.0 -2.48965 SP1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 17676974-TableS2 GeneSigDB Published Gene Signatures 1.0 null SNU-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -2.11363 FB-39-CW59_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.744531 anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.12452 H2AFZ_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68W-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null USF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WEY5-0226-SM-3GIKN GTEx Tissue Sample Gene Expression Profiles -1.0 -0.84387 intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041771 H3K4me3_astrocyte of the spinal cord_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.26176 Acute myeloid leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.934 CHD2_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 GTEX-RWS6-0326-SM-2XCAP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04206 NCIH2291_LUNG CCLE Cell Line Proteomics 1.0 4.42944 orbital frontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.989824 r9 part of the vestibular column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05738 hsa-miR-548c-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.145356 Diffuse large B-cell lymphoma cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.867 NB4 Achilles Cell Line Gene Essentiality Profiles 1.0 2.04727 PMC3226433-1756-8935-4-20-S1.XLS-Table_S5_Miz-1_KD_gene_exp_chan-Genes_up-regulated_in_Miz-1_KD_hESC_AR Rummagene Transcription Factor Associations 2026 1.0 null LARGE2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.92441 KMS11 CCLE Cell Line Gene CNV Profiles -1.0 -2.9443 KDM4A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GATA4 ChEA Transcription Factor Targets 1.0 null UPMD1 DepMap CRISPR Gene Dependency 1.0 3.28371 medial (fastigial) cerebellar nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31292 GATA1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-UPIC-0002-SM-3NMDC GTEx Tissue Sample Gene Expression Profiles 1.0 1.01322 GSE228430_2_v_3_fabp5_human RummaGEO Gene Perturbation Signatures 1.0 null COLO680N CCLE Cell Line Gene CNV Profiles 1.0 1.51169 GSE199606_3_v_0_ricin_mouse RummaGEO Drug Perturbation Signatures 1.0 null Pituitary BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.07722 Kidney renal papillary cell carcinoma_KIRP_TCGA-J7-8537-01A-11R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CerebellumPeduncles BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.945394 BCL3 ENCODE Transcription Factor Targets 1.0 null Kidney Chromophobe_KICH_TCGA-KN-8433-11A-01R-2315-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null forebrain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 POLR2A_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Large B-cell lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.117 finger TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.48048 hsa-miR-4755-3p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 PD-70-VS77_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.571187 PD-70-VS77_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.595298 KAT2A ENCODE Transcription Factor Targets 1.0 null JB-23-ZE86_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.532337 pancreas_6b HPA Tissue Sample Gene Expression Profiles -1.0 -0.890531 Perturb_6906_KD_DDR1_SRP334383 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 2.27591 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 ventromedial hypothalamic nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.33874 GTEX-XQ3S-0426-SM-4BOOA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50747 colorectum TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null MEL270 DepMap CRISPR Gene Dependency 1.0 2.09447 H3K36me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H1_Derived_Mesenchymal_Stem_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 0.947686 U-266 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.95174 GTEX-QVUS-0008-SM-447AY GTEx Tissue Sample Gene Expression Profiles 1.0 1.23172 NCIH660 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.04677 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A5R3-01A-11R-A28H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null STAT5A_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE216273,GSE216292_14_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures -1.0 null Nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.082 GSE223893_2_v_10_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_MEL cell line_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CHD2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE196117_1_v_0_clarithromycin_human RummaGEO Drug Perturbation Signatures 1.0 null NB-80-IM48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.17494 SK-MM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.3242 6963_PWP2_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.551073 cd8 cells HPM Cell Type and Tissue Protein Expression Profiles 1.0 1.14787 sirolimus_mus musculus_gpl1261_gse5332 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GTEX-XXEK-0926-SM-4BRWH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.995346 metencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 ATG16L2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.27524 A549_JNJ-26854165_10nM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.0124146 HT-55 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.946029 GSE239844_7_v_5_crizotinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE205163,GSE205164_3_v_6_znf808_human RummaGEO Gene Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.857451 Brain Lower Grade Glioma_LGG_TCGA-DH-5142-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null blood cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NANOG-21062744-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null facial motor nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.8565 PBX3_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF-31629814-HEPATOCYTES-MOUSE-TYROSINEMIA ChEA Transcription Factor Targets 2022 1.0 null 16715129-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null RERF-LC-OK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832513 CE-04-PX35_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.434488 embryoday8.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.59959 Entorhinal area, lateral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.90408 TAF7 ENCODE Transcription Factor Targets 1.0 null SK-ES-1 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.35664 SARS-dORF6_0Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.86702 H3K36me3_fibroblast of lung_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null internal female genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.23362 CREB1 ChEA Transcription Factor Targets 1.0 null anterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.13691 ventrolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.958736 H3K4me3_H7_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nucleus of the solitary tract, gelatinous part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.69995 GTEX-Q2AH-0126-SM-48U2B GTEx Tissue Sample Gene Expression Profiles 1.0 2.15456 layer III of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.59064 GSE149621_3_v_1_olaparib_human RummaGEO Drug Perturbation Signatures -1.0 null ZNF460 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 176.818 hippocampus (hippocampal formation)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.8354 Lung adenocarcinoma_LUAD_TCGA-67-3774-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE206093,GSE206094_1_v_3_isl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE195663_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832513 ETS1-20019798-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GTEX-REY6-0326-SM-2TF5A GTEx Tissue Sample Gene Expression Profiles -1.0 -1.91929 GTEX-Q2AH-0526-SM-2I3ED GTEx Tissue Sample Gene Expression Profiles -1.0 -0.947943 Prostate adenocarcinoma_PRAD_TCGA-KK-A7AW-01A-11R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.08944 TBP ENCODE Transcription Factor Targets 1.0 null RPE1SS48 DepMap CRISPR Gene Dependency 1.0 2.14507 H3K27ac_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCFC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null layer IIIu of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.15479 PMC4050971__F4 PFOCR Pathway Figure Associations 2024 1.0 null FF-86-NH56_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.357119 GSE193258,GSE193259_9_v_15_osimertinib_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me2_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null GSE165308_1_v_0_gfi1_human RummaGEO Gene Perturbation Signatures 1.0 null periventricular stratum of r7Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27191 TFAP2E JASPAR Predicted Human Transcription Factor Targets 2025 1.0 59.2647 H3K4me3_LNCaP clone FGC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null RD-90-OY66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.09833 C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18477 GSE200320_3_v_2_mfge8_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QV31-0226-SM-447BO GTEx Tissue Sample Gene Expression Profiles -1.0 -2.82689 SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.21079 H3K36me3_cardiac mesoderm_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Norwalk Virus_HG23_19515767_GSE15520 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.33022 KAT2A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null oculomotor nuclear complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.24275 GTEX-XBED-0526-SM-47JY3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.888029 LU-165 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.04249 MDAMB453 CCLE Cell Line Gene CNV Profiles -1.0 -1.70828 GTEX-RWS6-2126-SM-2XCAV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.11636 BD-49-MD69_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -7.61408 Lung squamous cell carcinoma_LUSC_TCGA-66-2787-01A-01R-0980-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SP1 ENCODE Transcription Factor Targets 1.0 null GSE160246_9_v_1_cpeb4_mouse RummaGEO Gene Perturbation Signatures -1.0 null SARS-BatSRBD_0Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.69625 KO52 CCLE Cell Line Gene CNV Profiles -1.0 -1.75296 BIRC5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.08755 GTEX-R53T-0426-SM-48FEM GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13071 SNU-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.93621 GSE149124,GSE149128_3_v_1_cdk7_mouse RummaGEO Gene Perturbation Signatures 1.0 null SETDB1 ENCODE Transcription Factor Targets 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-85-6798-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE148269,GSE148273_0_v_1_arid4b_human RummaGEO Gene Perturbation Signatures -1.0 null CHD1 ENCODE Transcription Factor Targets 1.0 null H3K27ac_Panc1_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null WE-43-PZ45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.279339 GSE154577_6_v_12_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null cerebellum TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Metabolism dbGAP Gene-Trait Associations 1.0 1.15755 GSE105169,GSE105175_0_v_1_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null SUP-T1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5201-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE77108_4_v_2_saha_human RummaGEO Drug Perturbation Signatures 1.0 null AC-86-XI84_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.300346 AKT1_knockout_212_GSE39699 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.2378 TAF10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.00774 upper (rostral) rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.06476 ZBTB7A_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CALU6 CCLE Cell Line Gene CNV Profiles 1.0 1.45692 trochlear nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.42806 Nucleus pulposus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.793 WHSC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE183113_1_v_0_sorafenib_human RummaGEO Drug Perturbation Signatures 1.0 null HS 852.T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.37232 MF-81-RJ18_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.288501 GTEX-QXCU-1926-SM-48FE4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.28991 posterodorsal tegmental nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.40889 GTEX-QESD-1626-SM-2S1RB GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03686 DMS 454 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.91281 BRD4_01_311 KnockTF Gene Expression Profiles with Transcription Factor Perturbations -1.0 -0.59587 MOLP2 CCLE Cell Line Gene CNV Profiles 1.0 2.07674 periventricular stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0439 H3K36me3_skeletal muscle myoblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KYSE-150 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.18631 GSE247862,GSE247863_4_v_1_eomes_mouse RummaGEO Gene Perturbation Signatures -1.0 null SAP30 ENCODE Transcription Factor Targets 1.0 null STAT3 ENCODE Transcription Factor Targets 1.0 null SARS-CoV MA15_Day4-PFU-10^4_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.67851 SETDB1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EB-A3Y7-01A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ETS1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CREB1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Nemaline Myopathy_Gastrocnemius Muscle_GSE3384 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.82868 Flocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14949 amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.26604 POLR2A_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYC_MCF-7_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null EE-98-PF86_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.977045 H3K36me3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC3153 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.965219 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3HZ-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null VZ in caudal cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.904814 GTEX-XUZC-0426-SM-4BOPE GTEx Tissue Sample Gene Expression Profiles 1.0 1.33096 GF-35-IT27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.493985 inner SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26931 Lingula (I), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.21922 BRCA1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Erythroleukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 GTEX-QEG5-1126-SM-33HC2 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07014 CW-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null FA-63-WI26_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -6.25189 animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GTEX-R55G-0126-SM-48FDS GTEx Tissue Sample Gene Expression Profiles 1.0 1.06314 TAF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE229973_3_v_2_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null DF-95-CY55_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.390833 GTEX-QCQG-0008-SM-48U2G GTEx Tissue Sample Gene Expression Profiles 1.0 1.87052 GTEX-NFK9-1726-SM-3TW8P GTEx Tissue Sample Gene Expression Profiles 1.0 0.889732 20081105-ST-2 GeneSigDB Published Gene Signatures 1.0 null mantle zone of r4Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13559 Brain Lower Grade Glioma_LGG_TCGA-QH-A6X8-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IRF1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SRF_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BE-81-QL64_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.23336 GTEX-POMQ-0326-SM-2I5FO GTEx Tissue Sample Gene Expression Profiles -1.0 -1.17172 MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00655 GTEX-QCQG-0426-SM-48U29 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.42983 GTEX-XV7Q-0226-SM-4BRVL GTEx Tissue Sample Gene Expression Profiles 1.0 1.50547 H3K9ac_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HT-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null POLR2A_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6945-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DA-58-LZ09_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.290717 GSE193624_1_v_0_med1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Sarcoma_SARC_TCGA-IS-A3K8-01A-11R-A21T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ventrolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.38108 Penis_Foreskin_Melanocyte_Primary_Cells_skin01 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.0744 GSE68156_3_v_4_dextran_mouse RummaGEO Drug Perturbation Signatures 1.0 null hsa-miR-4435 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 MXI1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRF1 ENCODE Transcription Factor Targets 1.0 null SW1990_PANCREAS CCLE Cell Line Proteomics 1.0 2.52592 H3K27ac_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE218171_1_v_0_foxn3_human RummaGEO Gene Perturbation Signatures -1.0 null MYBL2_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.27486 GSE217405_3_v_2_osimertinib_mouse RummaGEO Drug Perturbation Signatures -1.0 null KM12 COSMIC Cell Line Gene Mutation Profiles 1.0 null Necrosis CTD Gene-Disease Associations 1.0 1.17629 USF1_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-91-6849-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC11551338-pnas.2411189121.sd01.xlsx-AHR-Unnamed_0_AHR Rummagene Transcription Factor Associations 2026 1.0 null BNIP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.12942 GB-84-KP45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.261922 Ar JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.8764 H3K4me3_choroid plexus epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-TKQ2-0008-SM-4DM5L GTEx Tissue Sample Gene Expression Profiles 1.0 0.925562 r5 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01823 H3K27ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-548am TargetScan Predicted Conserved microRNA Targets 1.0 0.226173 GSE113734_1_v_0_qprt_human RummaGEO Gene Perturbation Signatures 1.0 null H3K36me3_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE209898,GSE209899_0_v_1_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null r10 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.28029 GSE223008_6_v_1_calhm6_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-PSDG-1526-SM-48TCY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3402 hsa-miR-3120-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.541706 r7 part of the posteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.97285 striatum_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.996277 GTEX-WFON-0326-SM-3GIKX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.3191 GABPA_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE100102_2_v_6_cgas_mouse RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-4419b TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RI-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null POLR2A_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-NPJ7-0006-SM-3GACR GTEx Tissue Sample Gene Expression Profiles 1.0 1.2025 GTEX-X5EB-0526-SM-46MVP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.994625 pancreas_6a HPA Tissue Sample Gene Expression Profiles -1.0 -0.931221 YY1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE103068_0_v_4_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2AphosphoS5_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-S9-A6TV-01A-12R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-WEY5-0426-SM-3GIKT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29002 frontal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.904714 RERFLCSQ1_LUNG CCLE Cell Line Proteomics 1.0 2.51987 myocardial infarction GAD Gene-Disease Associations 1.0 null SNCA_KO_GDS4153_530_mouse_striatum GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null UACC257 CCLE Cell Line Gene Expression Profiles 1.0 1.88025 POLR2AphosphoS5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GC-04-UF36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.508251 GTEX-QLQW-0326-SM-447A8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20988 Uvula (IX) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91372 PAX5_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-XR-A8TE-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1M6-01A-11R-A13Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZBTB33_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r2 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.65057 NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null hsa-miR-3616-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 Prostate adenocarcinoma_PRAD_TCGA-G9-6498-01A-12R-A311-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-6229-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SIX5_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null r6 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07861 PMC9883437-41467_2023_36150_MOESM4_ESM.xlsx-Chromatin_Regulators-AIRE_AIRE Rummagene Transcription Factor Associations 2026 1.0 null LS513_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 2.93335 DLD CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.59324 Lung adenocarcinoma_LUAD_TCGA-86-8674-01A-21R-2403-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null chromosomal part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.163865 AD-16-HL96_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.787408 GTEX-X8HC-0526-SM-4E3JA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.916455 SPI1_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_2_v_3_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-OXRP-2326-SM-2S1NL GTEx Tissue Sample Gene Expression Profiles -1.0 -2.22765 NFIA_Deficiency_GDS2775_639_mouse_Embryonic brains (at E18) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null CTCF_kidney_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-O5YT-1326-SM-3MJGR GTEx Tissue Sample Gene Expression Profiles 1.0 1.61265 Lung squamous cell carcinoma_LUSC_TCGA-79-5596-01A-31R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H1792 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.15669 ATF1 ENCODE Transcription Factor Targets 1.0 null abducens nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.41033 HCoV-EMC2012_7Hour_23631916_GSE45042 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.55305 NCI-H1703 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25722 Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8001-01A-11R-2204-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null forelimb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.213471 BE-79-QU25_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.284733 WholeBlood BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.901 GTEX-X3Y1-0726-SM-3P5YU GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90506 YD8 CCLE Cell Line Gene CNV Profiles 1.0 1.43386 EGR1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CD8_Naive_Primary_Cells Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -1.90562 SP1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WWYW-1326-SM-3NB2S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.86031 CREB1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MYBL1-21750041-SPERMATOCYTES-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Down Syndrome_CNS - Brain - Cerebellum (MMHCC)_GSE1611 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.73778 GTEX-WQUQ-0006-SM-3MJF4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.23482 GTEX-WRHU-1226-SM-4E3IJ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.9933 GTEX-Q2AI-1526-SM-3GIJ3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872093 FA-63-WI26_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.865106 BD-69-GX17_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.19316 YY1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V955-0126-SM-4JBH5 GTEx Tissue Sample Gene Expression Profiles 1.0 2.29479 Head and Neck squamous cell carcinoma_HNSC_TCGA-T2-A6WZ-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null isthmic roof plate Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.20811 CTCF_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-0426-SM-48TZX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.81905 GSE231799_3_v_4_nfkbie_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RN64-0326-SM-2TC5J GTEx Tissue Sample Gene Expression Profiles -1.0 -2.40549 bone marrow TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.09209 SCLC21H CCLE Cell Line Gene Expression Profiles -1.0 -3.3742 VIIIA, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.13317 Perturb_5173_KD_Hnrnpk_SRP078486 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 20.0 COLO 857 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46394 GABPA_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null reuniens nucleus (medioventral nucleus) of thalamus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.834349 GSE142210_9_v_0_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null 8489_STARD3_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.511704 CTCF_fibroblast of the aortic adventitia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ELK4_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TCF7-22412390-EML-MOUSE ChEA Transcription Factor Targets 2022 1.0 null MM253 DepMap CRISPR Gene Dependency 1.0 3.35549 GTEX-TMMY-1326-SM-4DXU9 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.49666 GSE144231_3_v_1_cxcr2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-NFK9-1626-SM-3LK5J GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16828 mantle zone of cerebellar vermis Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12358 KYSE-450 COSMIC Cell Line Gene Mutation Profiles 1.0 null GTEX-OHPN-0011-R11A-SM-2I5FM GTEx Tissue Sample Gene Expression Profiles -1.0 -0.891801 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M9-01A-23R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null intracellular membrane-bounded organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 PAX5_GM12878_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP1_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null binding GO Molecular Function Annotations 2015 1.0 null choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03881 G59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.00031 hsa-miR-22 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GTEX-WHPG-0826-SM-3NMBF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02887 Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.877393 GSE120370_4_v_3_thrombin_mouse RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1-20019798-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Escherichia coli infection of the central nervous system_CNS - Brain (MMHCC)_GSE3253 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.69045 GSE206784_2_v_4_ninl_human RummaGEO Gene Perturbation Signatures -1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_7day-MOI-10^3_None_GSE43302 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.5315 GTEX-W5X1-0826-SM-3GILN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04446 MAX_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE70883,GSE71179_0_v_1_pbx1_mouse RummaGEO Gene Perturbation Signatures -1.0 null RELA_GM19099_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JJN-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.07995 SG in inferolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.90295 Dot1l_DELETION_GDS4295_426_mouse_AF9 - Mixed Lineage Leukemia (MLL) cells - 3 days GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null vorinostat_homo sapiens_gpl10558_gse35242 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE129241_4_v_0_valproic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Thoracic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.098 ZMIZ1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XV7Q-0005-SM-4BRWI GTEx Tissue Sample Gene Expression Profiles 1.0 1.14595 ELF1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.52498 TRIM28_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8528285-pbio.3001085.s010.xlsx-Fig_S7B-GENE_LIST_UPLOADED_TO_ENRICHR_MAX_WT_TESTES_874_GENES_MAX Rummagene Transcription Factor Associations 2026 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-2W-A8YY-01A-11R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_HeLa-S3_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null MAFK ENCODE Transcription Factor Targets 1.0 null GTEX-XPVG-0826-SM-4B654 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.957193 GSE155162,GSE155169_1_v_0_buparlisib_human RummaGEO Drug Perturbation Signatures 1.0 null CAR-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.832843 Bladder Urothelial Carcinoma_BLCA_TCGA-GD-A3OS-01A-12R-A220-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null caudal division of IPC (area 39) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.28033 A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_4day-MOI-10^3_None_GSE43302 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.91724 hsa-miR-4751 TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 ST6GAL1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.26185 IB-33-TE51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.23869 GSE71468,GSE76476_0_v_3_rbfox1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-S4UY-0008-SM-3NM8H GTEx Tissue Sample Gene Expression Profiles 1.0 1.54598 H3K4me1_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SREBF1 ChEA Transcription Factor Targets 1.0 null GTEX-OOBJ-0008-SM-3NB26 GTEx Tissue Sample Gene Expression Profiles 1.0 1.44905 NSG1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.34439 BHT101 DepMap CRISPR Gene Dependency 1.0 2.0165 SOX3-22085726-NPCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GTEX-X4EO-0526-SM-3P5Z3 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44782 adult stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.0581 GTEX-U3ZM-0526-SM-4DXTB GTEx Tissue Sample Gene Expression Profiles 1.0 1.21632 SKHEP1 CCLE Cell Line Gene CNV Profiles 1.0 1.34234 GSE158834_0_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null PMC11151076-ADVS-11-2306486-s002.xlsx-TSPYL1_FOXA1_targets-DDB2_FOXA1 Rummagene Transcription Factor Associations 2026 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-C4-A0F1-01A-11R-A034-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE209898,GSE209899_0_v_1_flcn_human RummaGEO Gene Perturbation Signatures -1.0 null mediodorsal nucleus of thalamus_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20197 POLR2A_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null nfe2l2_20133372_lung_lof_mouse_gpl1261_gds3622 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.692743 H3K36me3_H7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZC3H11A ENCODE Transcription Factor Targets 1.0 null H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE229070,GSE229071_0_v_2_sotorasib_human RummaGEO Drug Perturbation Signatures 1.0 null OF-05-CB18_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.09518 CHD2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null wt1_17420277_e11dot5_urogenital_ridge_lof_mouse_gpl1524_gds2747 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.072313 GTEX-WFJO-0005-SM-3GIKY GTEx Tissue Sample Gene Expression Profiles 1.0 1.29534 GSE102486,GSE102490_1_v_5_setdb1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE146982_4_v_1_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.3464 roof plate of p2 (epithalamic roofplate) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.1268 EGR1 ENCODE Transcription Factor Targets 1.0 null AGS DepMap CRISPR Gene Dependency 1.0 3.27666 TAF1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T8EM-0826-SM-4DM76 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14618 Brain Lower Grade Glioma_LGG_TCGA-DU-6407-02B-11R-A36H-07,TCGA-DU-6407-02A-12R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r7 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.44444 SK-MEL-28 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.15418 U2 snRNP COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.855 SALL4-22934838-CD34+-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me3_myocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE57871_1_v_2_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_Jurkat_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null IC-05-AW29_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.406567 BE-79-QU25_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.46125 bone marrow HPA Tissue Gene Expression Profiles -1.0 -1.48751 GTEX-S3XE-0526-SM-4AD4G GTEx Tissue Sample Gene Expression Profiles -1.0 -1.90764 PMC2263127-pone.0001816.s002.xls-Terms_with_Genes_E2F3_up_Bild-Title_E2F3 Rummagene Transcription Factor Associations 2026 1.0 null ZNF705A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.25587 Foxo1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.8384 cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.167452 positive regulation of protein ubiquitination GO Biological Process Annotations 2023 1.0 null GSE169205_4_v_7_sirt5_human RummaGEO Gene Perturbation Signatures 1.0 null inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.930985 MYC_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CPEB4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04532 SUZ12_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AF-99-HA02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.96678 PMC10836071-media-2.xlsx-Supplementary_Table_5-ELK1_all_ELK1 Rummagene Transcription Factor Associations 2026 1.0 null HCC1576 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.33327 H3K4me3_cardiac muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC5927328-NIHMS77085-supplement-Table_S4.xlsx-Table_S4A_LPS_induced_genes_GO-Unnamed_13_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null cerebral lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5432-01A-02R-1686-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null U-698-M COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE213588_10_v_2_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null TCF12_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LC1SQSF CCLE Cell Line Gene Expression Profiles -1.0 -1.65902 TAF1_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBL1XR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K36me3_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null 19841744-TableS5 GeneSigDB Published Gene Signatures 1.0 null GSE213715_0_v_1_iqgap2_human RummaGEO Gene Perturbation Signatures -1.0 null YY1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SARS-CoV_12Hour_20090954_GSE17400 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.29215 hsa-miR-583 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GTEx Nerve 20-29 vs 40-49 GTEx Tissue-Specific Aging Signatures -1.0 -5.04076 ventrolateral prefrontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.914662 H3K4me3_endothelial cell of umbilical vein_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.13392 MAZ ENCODE Transcription Factor Targets 1.0 null ATF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXP2_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RFX5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hippocampus (hippocampal formation)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.89154 496100369_PCx_no dementia_TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.10501 ZBED4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 151.186 MDAMB453 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.38902 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Nfat5 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.6489 Central nervous system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 BRCA1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HCC202 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.35866 mantle zone of THyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11971 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null GTEX-U3ZM-0226-SM-4DXTA GTEx Tissue Sample Gene Expression Profiles 1.0 1.14407 CCT7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.91454 FOXP1-21924763-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE88819_7_v_9_tug1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Dehydration_CNS - Brain - Hypothalamus (MMHCC)_GSE4130 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 2.41453 KA-71-CQ35_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.376187 basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.871164 GTEX-SIU7-0006-SM-2XCE6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.30864 Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ER-01A-12R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BCLAF1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Frontal pole, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14813 COV644 CCLE Cell Line Gene Expression Profiles -1.0 -1.598 Lung adenocarcinoma_LUAD_TCGA-78-7149-01A-11R-2039-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27ac_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F6 ENCODE Transcription Factor Targets 1.0 null Entorhinal area, lateral part, layer 2a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35945 k-562 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.656242 BB-87-SF89_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.218685 POLR2A_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Primary hematopoietic stem cells G-CSF-mobilized Female RO_01508 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -1.20399 H3K4me3_HL-60_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE223893_11_v_10_setd2_human RummaGEO Gene Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-HM-A6W2-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null embryoday7.5 BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.16484 TAF1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE234043_3_v_1_abcb1_human RummaGEO Gene Perturbation Signatures 1.0 null eGFP-JUND_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ETS1-22383799-G1ME-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE154577_7_v_10_plagl1_human RummaGEO Gene Perturbation Signatures 1.0 null SUZ12 ENCODE Transcription Factor Targets 1.0 null U-698-M Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE227592_6_v_3_adar_human RummaGEO Gene Perturbation Signatures 1.0 null NRF1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZNF707 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 101.988 tonsil_8a1 HPA Tissue Sample Gene Expression Profiles 1.0 2.6576 NCI-H2081 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.993496 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null RCHACV DepMap CRISPR Gene Dependency 1.0 3.41267 PMC4909395-elife-13964-supp1.xlsx-Sheet1-Supplementary_file_1_shRNA_screen_hits_selective_to_ERG-positive_prostate_cancer_ERG Rummagene Transcription Factor Associations 2026 1.0 null SPI1-22096565-GC-B-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-A4ZV-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null hippocampus (hippocampal formation)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.75762 PMC8384902-mmc2.xlsx-3_ASCL1_high_subtype-Gene_Symbol_ASCL1 Rummagene Transcription Factor Associations 2026 1.0 null medial tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.56832 inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.13978 GTEX-PX3G-2026-SM-48U1H GTEx Tissue Sample Gene Expression Profiles 1.0 1.98109 H3K4me3_Panc1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-A5DJ-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me3_H1-hESC_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE142210_11_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-XUJ4-0626-SM-4BOOO GTEx Tissue Sample Gene Expression Profiles -1.0 -0.89177 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A556-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null skin TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.07096 POLR2AphosphoS5_G1E_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null myeloid leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.121855 Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SNU8 DepMap CRISPR Gene Dependency 1.0 3.56743 Perturb_4326_KO_Zcchc8_SRP187429 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 1.80283 RUNX3_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_CH12.LX_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TGBC24TKB Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.08171 Neutrophil percentage of white cells GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.10458 PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2 Rummagene Transcription Factor Associations 2026 1.0 null H3K36me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE160304,GSE163392_4_v_3_zswim8_human RummaGEO Gene Perturbation Signatures -1.0 null GSE200673,GSE200691_1_v_3_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE216273,GSE216292_0_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-SE5C-0326-SM-4BRWX GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07484 HCC1011 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.882347 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FW-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBP_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5193459-pone.0168968.s009.xlsx-Dharmacon_OTP_siRNA_Area-Symbol_OTP Rummagene Transcription Factor Associations 2026 1.0 null Perturb_6475_OE_circAKT3_SRP216548 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 -20.0 urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null 8505C Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.6864 GTEX-W5WG-0008-SM-4KL25 GTEx Tissue Sample Gene Expression Profiles 1.0 0.886634 7312_RIOK2_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.523316 EGR1-20690147-ERYTHROLEUKEMIA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null icSARS-Cov_Day4_None_GSE50000 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.59037 ZNF143 ENCODE Transcription Factor Targets 1.0 null GTEX-QCQG-0006-SM-2S1OW GTEx Tissue Sample Gene Expression Profiles 1.0 1.33946 Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JL-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-POMQ-1926-SM-3NB1Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.95673 NRF1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PX3G-1026-SM-48TZW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.21502 H3K9ac_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null PBX3_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-P3-A6T3-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QDVN-0426-SM-48TZ6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.10071 H3K9ac_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SNU-C1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.883704 GSE148066,GSE157787_11_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_retinal pigment epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OIZH-0126-SM-2HMIS GTEx Tissue Sample Gene Expression Profiles 1.0 1.39617 HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.866937 positive regulation of protein modification by small protein conjugation or removal GO Biological Process Annotations 2023 1.0 null H3K4me3_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-WHSB-0005-SM-3LK7C GTEx Tissue Sample Gene Expression Profiles 1.0 1.00038 NR2F1 JASPAR Predicted Transcription Factor Targets 1.0 null periventricular stratum of m2ADL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.55008 AA-23-FM46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.73765 VIM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07323 KM-12 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null GSE158834_1_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null HT-1080 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.03797 PMC4856960-supp_gkv1471_nar-01762-z-2015-File012.xlsx-GO_common_7H-HIF1_chip-Common_elements_in_chip7h_and_chip_hif1_2530_official_gene_symbols_HIF1A Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of lung_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_astrocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null negative regulation of protein-containing complex disassembly GO Biological Process Annotations 2025 1.0 null hsa-miR-626 TargetScan Predicted Conserved microRNA Targets 1.0 0.336728 leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.63907 DNTTIP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.17186 GSE142210_9_v_5_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null t-cell chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null a549 HPA Cell Line Gene Expression Profiles 1.0 0.950352 OCI-AML3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.914355 Meniscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.949 SMC3 ENCODE Transcription Factor Targets 1.0 null CHD7_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-8161-01A-11R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null COLO741_SKIN CCLE Cell Line Proteomics 1.0 2.74872 496100642_PCx_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.17836 H3K4me3_GM12865_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CBX3 ENCODE Transcription Factor Targets 1.0 null GSE162892_4_v_0_sox9_human RummaGEO Gene Perturbation Signatures -1.0 null FAM20C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28413 NCIH1092 CCLE Cell Line Gene Expression Profiles -1.0 -1.96552 Ionocyte cell_Lung_Human CellMarker Gene-Cell Type Associations 1.0 null TET2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.41108 STAM CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.05747 MAX_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ES4 DepMap CRISPR Gene Dependency 1.0 3.11352 GSE158834_7_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-T5JW-0008-SM-4DM5X GTEx Tissue Sample Gene Expression Profiles 1.0 1.21653 GSE82110,GSE82299_1_v_0_acriflavine_human RummaGEO Drug Perturbation Signatures 1.0 null thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.65086 GSE148066,GSE157787_9_v_7_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null Lobule III, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08843 dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.12995 FOSL2_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HINFP JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.1873 GSE239541_11_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.47469 H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-5929-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K36me3_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE119498_6_v_4_setd5_mouse RummaGEO Gene Perturbation Signatures 1.0 null ventrolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.998301 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_CD8 Naive Primary Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05255 ELK4_HEK293_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05255 KA-75-LP02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.41765 PHF8_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH2066 CCLE Cell Line Gene CNV Profiles 1.0 2.0807 GSE125403_7_v_0_venetoclax_human RummaGEO Drug Perturbation Signatures -1.0 null NF-21-HQ00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.505761 hsa-miR-548x TargetScan Predicted Conserved microRNA Targets 1.0 0.226173 ventrolateral prefrontal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.931294 A-CA-04-2009(H1N1)_0Hour_23935999_GSE47960 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.88219 HB-06-WU12_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.46645 H3K27ac_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null MID1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09889 GSE229698_1_v_2_traf7_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-X62O-0008-SM-46MU5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.60467 RAD21 ENCODE Transcription Factor Targets 1.0 null RFX5 ENCODE Transcription Factor Targets 1.0 null SPI1-23547873-NB4-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE184210_0_v_3_glucagon_mouse RummaGEO Drug Perturbation Signatures 1.0 null USF1 ENCODE Transcription Factor Targets 1.0 null GTEX-WFG8-1926-SM-4LVM1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.831002 GTEX-XQ3S-1726-SM-4BOOD GTEx Tissue Sample Gene Expression Profiles 1.0 1.07138 H3K4me1_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HC-74-HM63_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.826249 Acute biphenotypic leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.231 mantle zone of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01333 HCC60 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.25722 PAAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.2267 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5109-01A-02R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EST1-17652178-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MAX_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FLI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null Sarcoma_SARC_TCGA-DX-A3M2-01A-21R-A22K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null lung TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054847 H3K27ac_HCT116_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U8T8-0008-SM-4DXSP GTEx Tissue Sample Gene Expression Profiles 1.0 0.913198 KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.992332 uterus TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null HS 69ST Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.896264 Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3453-01A-02R-1277-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-NFKB1_mod_NFKB1 Rummagene Transcription Factor Associations 2026 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-BF-A5ES-01A-11R-A27Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC3964217-oncotarget-05-417-s001.xls-Supplemental_Table_3-GABPA-bound_promoters_GABPA Rummagene Transcription Factor Associations 2026 1.0 null ChIP_POU5F1_18347094 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null RCM1 DepMap CRISPR Gene Dependency 1.0 2.46247 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.52806 Vital Capacity DisGeNET Gene-Phenotype Associations 1.0 null GSE110178_2_v_6_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null Mitochondrial cloud COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.779 H3K4me2_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE203485_1_v_0_sunitinib_human RummaGEO Drug Perturbation Signatures 1.0 null A549_Cerdulatinib_10µM_24h Sci-Plex Drug Perturbation Signatures 1.0 0.00922119 hippocampus (hippocampal formation)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.872311 Uvula (IX), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.76778 cell part LOCATE Predicted Protein Localization Annotations 1.0 null CA-48-SW47_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.17173 PMC9316731-13059_2022_2728_MOESM2_ESM.xlsx-S3_AlternativeTSS_ZF-D3A-wt-Gene_CREBZF Rummagene Transcription Factor Associations 2026 1.0 null GSE186483_6_v_0_lrrk2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K4me3_fibroblast of dermis_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null HS294T CCLE Cell Line Gene Expression Profiles 1.0 1.79447 6558_POLR3D_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.15441 GLIS3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 35.0699 THP-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.74479 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6951-01A-11R-1915-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-QLQ7-1726-SM-2S1QQ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24114 NCI-H345 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.28556 OVK18 DepMap CRISPR Gene Dependency 1.0 2.62868 DF-26-EY87_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.660709 GTEX-XMK1-0326-SM-4B652 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50426 primary motor-sensory cortex (samples)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.38696 Arnt MotifMap Predicted Transcription Factor Targets 1.0 null hsa-miR-3155 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 CTCF_limb_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5JL-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE119498_2_v_4_setd5_mouse RummaGEO Gene Perturbation Signatures 1.0 null PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-8cell_GSC-Unnamed_1_GSC Rummagene Transcription Factor Associations 2026 1.0 null hsa-miR-4478 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.7397 GSE216273,GSE216292_14_v_8_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-XGQ4-0226-SM-4GIDS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.51217 ChIP_SOX2_18692474 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null HCFC1_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-T6MO-0526-SM-4DM6R GTEx Tissue Sample Gene Expression Profiles 1.0 0.842165 WRNIP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sperm midpiece COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.546 TAF1_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.27583 Nrf2_deficiency_GDS3406_156_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE110708_0_v_3_adar_mouse RummaGEO Gene Perturbation Signatures 1.0 null MB-46-BT89_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.630452 ventrolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.27216 hsa-miR-484 MiRTarBase microRNA Targets 1.0 null POLR2A ENCODE Transcription Factor Targets 1.0 null H3K4me3_WI38_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null Cortical amygdalar area, posterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20133 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IJ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158834_10_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.64484 SW 1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.830435 SIX5_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE240386,GSE242143_1_v_6_morc2_human RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_cardiac mesoderm_hg19_7 ENCODE Histone Modification Site Profiles 1.0 null H3K27ac_K562_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GABPA_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null WC-09-GD62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.530608 Brain Lower Grade Glioma_LGG_TCGA-E1-5322-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE209601_0_v_1_mef2a_human RummaGEO Gene Perturbation Signatures -1.0 null SP1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC11743796-41420_2025_2295_MOESM5_ESM.xlsx-aged_LPS_BV-2_vs_human_upreg-mouse_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6790-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OF-05-CB18_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.539417 Adrenocortical carcinoma_ACC_TCGA-OR-A5LH-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE158834_11_v_8_palmitic acid_human RummaGEO Drug Perturbation Signatures 1.0 null GTEX-SE5C-0626-SM-2XCDV GTEx Tissue Sample Gene Expression Profiles -1.0 -1.01011 SOX11-23321250-Z138-A519-JVM2-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H2AFZ_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Acute Monocytic Leukemia DisGeNET Gene-Disease Associations 1.0 null Rectum adenocarcinoma_READ_TCGA-AF-2687-01A-02R-1736-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YY1_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ES4 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.22073 CTNNB1 ChEA Transcription Factor Targets 1.0 null GTEX-QLQW-1326-SM-2S1QS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50216 PMC6543837-Table_9.XLSX-In_vivo_M2_LPS--Supplementary_Table_9_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null SKMEL24 DepMap CRISPR Gene Dependency 1.0 2.78531 H3ac_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-QLQ7-0526-SM-2I5G3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.968933 EE-03-SG02_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.361946 GABPA_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GR-A4D6-01A-11R-A31O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HS821T CCLE Cell Line Gene CNV Profiles 1.0 1.48417 SAP30_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF ENCODE Transcription Factor Targets 1.0 null H3K4me1_mononuclear cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE167224,GSE168147_3_v_5_hnrnpk_human RummaGEO Gene Perturbation Signatures -1.0 null H2AFZ_CD14-positive monocyte_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PDX1-19855005-MIN6-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K27ac_endothelial cell of umbilical vein_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me3_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null tail of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.17472 GTEX-QEG4-0426-SM-33HC3 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.950176 Kidney renal papillary cell carcinoma_KIRP_TCGA-GL-A4EM-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2A_MCF-7_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Myelodysplastic syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.375 CHD1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TAF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AA-11-RO46_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.25178 H3K36me3_BJ_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A57G-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE119498_0_v_5_setd5_mouse RummaGEO Gene Perturbation Signatures -1.0 null COR-L47 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.47564 GTEX-S7SF-1626-SM-3K2AY GTEx Tissue Sample Gene Expression Profiles -1.0 -1.40236 H3K4me3_MCF-7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H2AFZ_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null telencephalon TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Kidney renal clear cell carcinoma_KIRC_TCGA-DV-5568-01A-01R-1541-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MZF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.4459 respiratory system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 SP1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null E2F4 ENCODE Transcription Factor Targets 1.0 null GSE158834_10_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null H2BK5ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null YY1_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TSE9-0011-R9A-SM-3DB7Q GTEx Tissue Sample Gene Expression Profiles -1.0 -1.08568 ELF1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAPAN1 DepMap CRISPR Gene Dependency 1.0 3.09871 GTEX-P44H-0011-R4A-SM-2XCEW GTEx Tissue Sample Gene Expression Profiles -1.0 -0.864915 KLF4-18358816-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null PMC11073998-41375_2024_2235_MOESM9_ESM.xlsx-THP1_phosphoproteome-Unnamed_2_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null Blood cancer cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HEP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09298 NCI-H1092 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.832513 DETROIT562_UPPER_AERODIGESTIVE_TRACT CCLE Cell Line Proteomics 1.0 6.32028 GSE86507,GSE86509_0_v_1_hoxb7_mouse RummaGEO Gene Perturbation Signatures -1.0 null intracellular non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046683 GATA1_erythroblast_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XOTO-0011-R9A-SM-4GICI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.14419 Declive (VI) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.58052 anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -2.72502 SW 900 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.959421 GTEX-Q2AI-0008-SM-48U2H GTEx Tissue Sample Gene Expression Profiles 1.0 2.24548 GSE223540_0_v_3_anxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null H3K9ac_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-U8XE-0726-SM-3DB8O GTEx Tissue Sample Gene Expression Profiles -1.0 -1.0627 ELK1-19687146-Hela cells-human ChEA Transcription Factor Binding Site Profiles 1.0 null H3K36me3_endothelial cell of umbilical vein_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_id_AR Rummagene Transcription Factor Associations 2026 1.0 null hippocampus (hippocampal formation)_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.873453 GSE186633_2_v_0_chd1_human RummaGEO Gene Perturbation Signatures -1.0 null TRIM28_U2OS_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOS_MCF 10A_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null CAL-54 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.38122 Sarcoma_SARC_TCGA-MJ-A850-01A-11R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null olfactory tubercle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.09914 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null E2F4_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null REST_neural cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P78B-0008-SM-48TE1 GTEx Tissue Sample Gene Expression Profiles 1.0 0.886567 GSE158834_2_v_4_palm_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-T6MN-0426-SM-32PMF GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06215 496100318_PCx_probable Alzheimer's disease_TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.53673 GSE219274,GSE219276_2_v_1_doxorubicin_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-SNOS-0008-SM-4DM6I GTEx Tissue Sample Gene Expression Profiles 1.0 1.6818 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7414-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XLM4-0005-SM-4AT4P GTEx Tissue Sample Gene Expression Profiles 1.0 0.90368 HCC70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.913843 10803_NON-TARGETING_NON-TARGETING Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.612989 TA-34-CK62_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.37004 POLR2AphosphoS5_GM12892_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ARHGEF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -3.09513 GSE168401_2_v_0_harmine_human RummaGEO Drug Perturbation Signatures -1.0 null superficial stratum of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.88128 stratum lacunosum-moleculare of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09679 KDM1A_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-RWSA-0726-SM-2XCBE GTEx Tissue Sample Gene Expression Profiles -1.0 -1.95293 r10 part of external cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.30005 GTEX-OHPL-0326-SM-33HC8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.69929 GTEX-S7SF-2026-SM-3K2AS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.57421 GATA3 ENCODE Transcription Factor Targets 1.0 null XRN2-22483619-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null AA-23-FM46_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.412267 Brain Lower Grade Glioma_LGG_TCGA-DU-A5TW-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4891-01A-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABP-17652178-JURKAT-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-55-6986-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MAX_A549_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE130383_2_v_0_gps2_mouse RummaGEO Gene Perturbation Signatures -1.0 null PMC10879698-mmc1.pdf-12-ZNF2_ZNF2 Rummagene Transcription Factor Associations 2026 1.0 null prostate BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.32728 MDAMB134VI Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.753628 POLR2A_HGPS cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDAMB157 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.690558 SPI1 ENCODE Transcription Factor Targets 1.0 null cellular_component COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GB-73-QS80_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.946486 gefitinib_homo sapiens_gpl570_gse20854 GEO Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Zinc finger, RING/FYVE/PHD-type InterPro Predicted Protein Domain Annotations 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4774-01A-01R-1289-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null 9686_UTP3_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures -1.0 -0.528996 GTEX-S3XE-0126-SM-4AD4R GTEx Tissue Sample Gene Expression Profiles 1.0 1.13924 GPN2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.4191 H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Breast disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.096 ion binding GO Molecular Function Annotations 2015 1.0 null SREBF1 ENCODE Transcription Factor Targets 1.0 null H3K4me3_foreskin fibroblast_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE149943_2_v_3_cd8a_mouse RummaGEO Gene Perturbation Signatures 1.0 null Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.934815 GSE146982_3_v_1_gpd1_human RummaGEO Gene Perturbation Signatures -1.0 null GTEX-QV31-0008-SM-447AT GTEx Tissue Sample Gene Expression Profiles 1.0 1.73107 REST_SK-N-SH_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V1D1-0226-SM-4JBHG GTEx Tissue Sample Gene Expression Profiles 1.0 1.04173 nucleus GO Cellular Component Annotations 2023 1.0 null NFATC1 ENCODE Transcription Factor Targets 1.0 null AE-39-DG66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.208055 VZ in subgenual cingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.12227 GTEX-OXRN-1726-SM-3NM9B GTEx Tissue Sample Gene Expression Profiles 1.0 1.16864 primary visual cortex (striate cortex, area V1/17)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.12567 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDAMB435S CCLE Cell Line Gene CNV Profiles 1.0 1.83396 Obesity_Muscle - Striated (Skeletal) (MMHCC)_GSE5109 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.86937 MAX_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WFJO-0008-SM-4LVN7 GTEx Tissue Sample Gene Expression Profiles 1.0 0.91435 MON DepMap CRISPR Gene Dependency 1.0 3.8246 DD-42-PC65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.40522 KDM5A ENCODE Transcription Factor Targets 1.0 null GTEX-NFK9-0926-SM-2HMJU GTEx Tissue Sample Gene Expression Profiles -1.0 -0.828216 pre-B-lymphocyte cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.954 GSE210101,GSE210114_5_v_9_urod_human RummaGEO Gene Perturbation Signatures 1.0 null CA-68-TC79_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.20613 Kidney renal papillary cell carcinoma_KIRP_TCGA-B1-A47M-01A-11R-A24Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE102269_1_v_2_clpp_mouse RummaGEO Gene Perturbation Signatures -1.0 null inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02528 GSE120370_0_v_6_thrombin_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_fibroblast of skin of abdomen_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-SUCS-0526-SM-4DM56 GTEx Tissue Sample Gene Expression Profiles 1.0 2.06611 primary motor cortex (area M1, area 4)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00103 NCI-H446 COSMIC Cell Line Gene Mutation Profiles 1.0 null hsa-miR-125a-5p TargetScan Predicted Conserved microRNA Targets 1.0 0.31417 SUM159PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.944883 NCI-H196 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.863434 MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.880077 amygdaloid complex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.3646 H3K9ac_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SYK_druginhibition_290_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.45825 H3K4me3_kidney epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Degenerative Polyarthritis DisGeNET Gene-Disease Associations 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GO-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null zona incerta Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.886134 ZNF143_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CL-34 COSMIC Cell Line Gene Mutation Profiles 1.0 null GSE120413,GSE120447_0_v_1_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE184210_0_v_1_glucagon_mouse RummaGEO Drug Perturbation Signatures 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39W-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal thalamus_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.21069 central nervous system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 Brain Lower Grade Glioma_LGG_TCGA-DB-5277-01A-01R-1470-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Myeloid leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.896 SMARCB1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE142210_11_v_8_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null MF-41-QM60_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.223483 H3K27ac_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE210101,GSE210114_8_v_9_urod_human RummaGEO Gene Perturbation Signatures 1.0 null GSE125007,GSE125008_1_v_0_uhrf1_mouse RummaGEO Gene Perturbation Signatures -1.0 null GSE165704_0_v_1_rif1_mouse RummaGEO Gene Perturbation Signatures 1.0 null AB-33-EM56_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.67387 H3K4me2_osteoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE217071_3_v_0_ythdf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null GTEX-XMK1-0226-SM-4B65D GTEx Tissue Sample Gene Expression Profiles 1.0 1.92284 GSE103068_5_v_3_volasertib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-PVOW-0426-SM-2XCF8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38375 Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MV-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-PWOO-0008-SM-48TDU GTEx Tissue Sample Gene Expression Profiles 1.0 1.38398 hsa-miR-4645-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 0.809003 CAMA-1 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.80378 GSE220914_2_v_0_zdhhc2_mouse RummaGEO Gene Perturbation Signatures 1.0 null amygdaloid complex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.1554 H3K4me1_K562_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me2_A549_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null external granular (germinal) layer of lower rhombic lip Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.885654 H3K36me3_fibroblast of dermis_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-0226-SM-4DM6V GTEx Tissue Sample Gene Expression Profiles 1.0 2.45859 GTEX-Q2AG-0008-SM-48U2K GTEx Tissue Sample Gene Expression Profiles 1.0 2.72618 amygdalohippocampal transition zone, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.72755 GSE82032_3_v_2_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GSE57871_6_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null H3K36me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-M7-A724-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HDAC1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE229468,GSE229471_0_v_1_znf587_human RummaGEO Gene Perturbation Signatures 1.0 null KE37 DepMap CRISPR Gene Dependency 1.0 2.51606 SIN3A_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-TKQ2-0826-SM-33HB6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.34578 GSE120370_0_v_3_thrombin_mouse RummaGEO Drug Perturbation Signatures 1.0 null BJAB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.63718 r5 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16579 H3K4me3_cardiac mesoderm_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -2.06079 GTEX-VJYA-0826-SM-4KL1M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.03251 GSE125025_2_v_3_lyl1_mouse RummaGEO Gene Perturbation Signatures -1.0 null PPARG ChEA Transcription Factor Targets 1.0 null Heart BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.14011 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE110178_5_v_7_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_choroid plexus epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null ventrolateral periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43898 primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12622 Diffuse large B-cell lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.135 PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_12_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null KYSE-450 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.27989 PMC8384902-mmc5.xlsx-H128_PROX1_ChIP-Symbol_PROX1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-SNMC-0926-SM-4DM5U GTEx Tissue Sample Gene Expression Profiles 1.0 0.978346 USF1_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE158834_12_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 PAX5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A549 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.92647 Cortical amygdalar area, posterior part, lateral zone, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02791 ZNF148 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 322.422 BT16 DepMap CRISPR Gene Dependency 1.0 2.45489 POLR2AphosphoS5_U-87 MG_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE247084,GSE247087_0_v_1_cdyl_mouse RummaGEO Gene Perturbation Signatures 1.0 null brain TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GABPA_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BD-49-MD69_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.727506 TASK1 DepMap CRISPR Gene Dependency 1.0 2.91829 EP300_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null DB-54-GQ68_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.232242 lateral mammillary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41635 CEBPB_HepG2_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GABP-17652178-JURKAT-HUMAN ChEA Transcription Factor Targets 2022 1.0 null MEC1 CCLE Cell Line Gene Expression Profiles -1.0 -1.69742 GTEX-QXCU-1726-SM-2TC6L GTEx Tissue Sample Gene Expression Profiles -1.0 -2.51608 PMC4856960-supp_gkv1471_nar-01762-z-2015-File010.xls-Genes_5kb_E2F7_Hyp-gene_name_E2F7 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-RVPU-0011-R3A-SM-2XCAE GTEx Tissue Sample Gene Expression Profiles -1.0 -0.893707 lymph node HPA Tissue Gene Expression Profiles 1.0 0.837889 MDA-MB-435 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.82477 B-cell lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.048 PMC10120406-JEM_20220962_DataS2.xlsx-Elf1_target-Data_S2_List_of_Elf1-target_genes_2_d_after_LPS_pIpC_stimulation_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE234637_3_v_0_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-S4Z8-0126-SM-4GICC GTEx Tissue Sample Gene Expression Profiles 1.0 1.30122 mantle zone of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.7768 ZBTB33_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Multiple myeloma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.096 ZR-75-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16775 YY1_NT2-D1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K27ac_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null COLO 680N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.21022 superficial stratum of r7Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.97285 CRX-20693478-ADULT-RETINA-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT5A ENCODE Transcription Factor Targets 1.0 null Oral mucosa TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 r7 part of the dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72811 GSE241036_0_v_1_ethanol_mouse RummaGEO Drug Perturbation Signatures 1.0 null SIN3A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSH-0005-SM-3NB2H GTEx Tissue Sample Gene Expression Profiles 1.0 1.12678 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RREB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 195.909 PMC11216188-peerj-12-17616-s013.pdf-276-CAMTA2_CAMTA2 Rummagene Transcription Factor Associations 2026 1.0 null H3K27ac_HepG2_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SNU638 DepMap CRISPR Gene Dependency 1.0 3.57134 EOMES ChEA Transcription Factor Targets 1.0 null PMC4050971__F4 PFOCR Pathway Figure Associations 2023 1.0 null H3K4me3_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null spleen GTEx Tissue Gene Expression Profiles 1.0 0.985684 negative regulation of organelle assembly GO Biological Process Annotations 2025 1.0 null GTEX-U8XE-0126-SM-4E3I3 GTEx Tissue Sample Gene Expression Profiles 1.0 1.12428 GSE203017_0_v_1_irs2_human RummaGEO Gene Perturbation Signatures 1.0 null occipital lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE148066,GSE157787_5_v_1_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lobule II Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57915 SREBP1-19666523-LIVER-FROM-C57BL-MICE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.00672 Acute promyelocytic leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.949 GTEX-XBED-2626-SM-4E3J5 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.04042 hsa-miR-1321 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.843347 GSE219195_4_v_2_rbm12_human RummaGEO Gene Perturbation Signatures -1.0 null ES5 DepMap CRISPR Gene Dependency 1.0 2.05221 superficial stratum of PO2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24716 Sarcoma_SARC_TCGA-DX-A8BK-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CW-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null SNU-601 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.93642 NCI-H727 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -4.59457 EHF CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.67553 SARS-ddORF6_0Hour_23935999_GSE47961 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.90297 POLR2A_cerebellum_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of lung_hg19_5 ENCODE Histone Modification Site Profiles 1.0 null ZNF143_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TP53 ChEA Transcription Factor Targets 1.0 null GTEX-NL3H-0006-SM-2I3FW GTEx Tissue Sample Gene Expression Profiles 1.0 1.06441 POLR2AphosphoS2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RT-112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.63718 ES-I3 Cells Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 1.08532 PMC7468443-Data_Sheet_2.xlsx-DEG_2h_LPS-Unnamed_7_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.1774 GSE158834_2_v_9_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NAAA CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.13069 HDAC2_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-P4QT-1326-SM-3NMD3 GTEx Tissue Sample Gene Expression Profiles 1.0 0.88103 GTEX-XOTO-0326-SM-4B66K GTEx Tissue Sample Gene Expression Profiles -1.0 -1.02614 GSE142210_3_v_5_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null SKNEP1 DepMap CRISPR Gene Dependency 1.0 2.13513 GTEX-P44H-0008-SM-48TDW GTEx Tissue Sample Gene Expression Profiles 1.0 1.40547 GTEX-U4B1-0126-SM-4DXSN GTEx Tissue Sample Gene Expression Profiles 1.0 1.3424 r6 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.91199 primary motor cortex (area M1, area 4)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.43668 GSE118548_1_v_3_trametinib_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-V1D1-0526-SM-4JBGW GTEx Tissue Sample Gene Expression Profiles -1.0 -1.6127 POLR2A_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SCLC-22H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.874024 H3K4me3_bronchial epithelial cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null DD-65-SA37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -5.38946 PMC11925450-elife-96850-supp2.xlsx-DNMT1_KO_vs_DNMT1_L1TD1_dKO_res-geneName_DNMT1 Rummagene Transcription Factor Associations 2026 1.0 null Endocrine system disease DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.601 U266B1 CCLE Cell Line Gene CNV Profiles -1.0 -1.88765 SP8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 118.896 GSE232786_1_v_0_otud1_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-RVPU-0011-R9A-SM-3NM8E GTEx Tissue Sample Gene Expression Profiles -1.0 -1.7827 G-401 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.606 NKX2-3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7756 A2780 CCLE Cell Line Gene Expression Profiles 1.0 1.91377 GTEX-PVOW-0726-SM-2XCF5 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.931412 H3K4me3_keratinocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null primary motor cortex (area M1, area 4)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.40153 17533364-TableS2 GeneSigDB Published Gene Signatures 1.0 null hsa-miR-3166 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.20993 Myeloblast TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.505 FE-82-WB22_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.10573 KLC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09457 Entorhinal area, lateral part, layer 2b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20049 HDAC1 ENCODE Transcription Factor Targets 1.0 null SYK_druginhibition_285_GSE43510 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.66888 GSE102757_1_v_0_panobinostat_mouse RummaGEO Drug Perturbation Signatures -1.0 null Perihypoglossal nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09389 RAD21_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RAD21_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE135352_6_v_3_napabucasin_human RummaGEO Drug Perturbation Signatures -1.0 null LS1034 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.993496 REST ENCODE Transcription Factor Targets 1.0 null GTEX-XBEC-0326-SM-4AT4M GTEx Tissue Sample Gene Expression Profiles -1.0 -1.13275 cisplatin_homo sapiens_gpl570_gse23553 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null ELK1_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Mucosa TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Postpiriform transition area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22837 periventricular stratum of r4Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0244 head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.947552 ACTN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.91972 primary auditory cortex (core)_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.973902 GTEX-W5WG-0006-SM-3GIJT GTEx Tissue Sample Gene Expression Profiles 1.0 0.980884 KASUMI6 CCLE Cell Line Gene CNV Profiles -1.0 -1.36487 mediodorsal nucleus of thalamus_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.854624 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A8HY-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Large intestine TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 r10 part of basointermediate reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5617 H3K4me3_HL-60_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null 496100339_HIP_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.03495 Nucleus of the solitary tract, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14168 GTEX-V955-1926-SM-4KL1L GTEx Tissue Sample Gene Expression Profiles 1.0 0.961066 GSE199921_1_v_0_romidepsin_mouse RummaGEO Drug Perturbation Signatures -1.0 null BHT-101 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -5.69073 IRF1_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 2.04756 striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.855257 Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5456-11A-02R-1503-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE239541_5_v_7_bmal1_mouse RummaGEO Gene Perturbation Signatures 1.0 null MAX_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TBL1XR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2A_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null karpas707 HPA Cell Line Gene Expression Profiles -1.0 -2.13485 GSE168473_0_v_1_isoniazid_human RummaGEO Drug Perturbation Signatures -1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3383-01A-02R-1325-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HC-74-HM63_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.679332 limb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.109916 Fatty Liver CTD Gene-Disease Associations 1.0 1.30238 PMC5749161-supp_gad.305813.117_Supplemental_Table_S1.xlsx-CLOCK_ChIP_database-Supplemental_Table_S1_ChIP_seq_database_and_gene_set_intersections_CLOCK Rummagene Transcription Factor Associations 2026 1.0 null Frontal pole, cerebral cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01958 DE-34-DT75_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.322582 H3K27ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TCF3 ENCODE Transcription Factor Targets 1.0 null GTEX-S7SF-1826-SM-3K2AD GTEx Tissue Sample Gene Expression Profiles -1.0 -0.964974 GSE180468_2_v_0_arid1a_human RummaGEO Gene Perturbation Signatures -1.0 null SIRT6 ENCODE Transcription Factor Targets 1.0 null negative regulation of macroautophagy GO Biological Process Annotations 2023 1.0 null TAF1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 114.327 MXI1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COR-L88 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.16775 2723_ERVW-1_ENST00000493463.2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.50263 POLR2AphosphoS5_GM12891_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_13458_KO_Foxm1_SRP217662 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 6.08674 ZNF143_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Penis_Foreskin_Melanocyte_Primary_Cells_skin03 Roadmap Epigenomics Cell and Tissue Gene Expression Profiles 1.0 1.13726 PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_DN_NR2F1_ind_DN-NR2F1_Ind_DN_NR2F1 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_HEK293_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null NFIC_ECC-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SPI1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q734-0126-SM-48U1E GTEx Tissue Sample Gene Expression Profiles 1.0 1.56828 hsa-miR-558 TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 FLI1 ChEA Transcription Factor Targets 1.0 null GTEX-R45C-0926-SM-3GAD4 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.29803 JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null ZNF263 ENCODE Transcription Factor Targets 1.0 null primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.35341 mantle zone of r6Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43291 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 BC-10-SB73_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.58609 NZM7 DepMap CRISPR Gene Dependency 1.0 2.26846 POLR2AphosphoS5_PFSK-1_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-X88G-0006-SM-47JX5 GTEx Tissue Sample Gene Expression Profiles 1.0 1.14761 NFKB1 JASPAR Predicted Transcription Factor Targets 1.0 null Lingula (I), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.48055 PML_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SIX5_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAZ JASPAR Predicted Human Transcription Factor Targets 2025 1.0 175.578 EZH2 ENCODE Transcription Factor Targets 1.0 null MYBL1-21750041-SPERMATOCYTES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null GSE220520_5_v_2_ethanol_mouse RummaGEO Drug Perturbation Signatures -1.0 null HHV-8_72Hour_18587055_GSE6489 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.958494 CHD1_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE132369,GSE132371_2_v_0_cccp_human RummaGEO Drug Perturbation Signatures -1.0 null H3K36me3_CH12.LX_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.11471 Chromatin lock complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.05 mantle zone of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05681 PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null intermediate stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.27924 PMC5013636-ncomms12601-s5.xlsx-SP1-Groups_SP1 Rummagene Transcription Factor Associations 2026 1.0 null GSE57871_11_v_10_vorinostat_human RummaGEO Drug Perturbation Signatures -1.0 null PFEIFFER CCLE Cell Line Gene CNV Profiles -1.0 -1.31998 GSE235390_4_v_0_lurbinectedin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_astrocyte of the cerebellum_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Nodulus (X) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6079 POLR2AphosphoS5_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10511 BC-25-VR48_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.04738 Breast cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.099 PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX Rummagene Transcription Factor Associations 2026 1.0 null H3K4me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE71674,GSE71676_0_v_2_cbfa2t2_mouse RummaGEO Gene Perturbation Signatures -1.0 null RT-112 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.46322 GTEX-P44H-0526-SM-2XCF1 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.841219 TOV112D CCLE Cell Line Gene Expression Profiles 1.0 2.69586 CF-65-GU65_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.438008 Medial amygdalar nucleus, anteroventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.45771 POLR2A_MCF-7_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null EBF1 ENCODE Transcription Factor Targets 1.0 null GSE158834_10_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RR-01A-21R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null CHD1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null KA-29-AB08_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.64765 Vermal regions Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36191 GSE155800_1_v_0_imatinib_human RummaGEO Drug Perturbation Signatures 1.0 null JF-96-HH81_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.259031 HMGN3 ENCODE Transcription Factor Targets 1.0 null GTEX-XOTO-0226-SM-4B66H GTEx Tissue Sample Gene Expression Profiles -1.0 -0.977351 Perturb_17328_KO_Dis3_SRP278122 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 13.7299 GTEX-PW2O-0226-SM-48TC7 GTEx Tissue Sample Gene Expression Profiles 1.0 1.54833 hsa-miR-4510 TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 H3K27ac_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null hsa-miR-4319 TargetScan Predicted Conserved microRNA Targets 1.0 0.303626 MYBL1 ChEA Transcription Factor Targets 1.0 null primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.04984 supragenual nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31508 FHL3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19813 GABPA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.7381 FB-49-NW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.928827 GSE201042_2_v_3_ptpmt1_mouse RummaGEO Gene Perturbation Signatures 1.0 null ZIC5 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 104.351 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.35186 GSE234637_3_v_0_ikzf1_human RummaGEO Gene Perturbation Signatures -1.0 null Pyramus (VIII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.83284 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040695 JUND_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-V1D1-0626-SM-4JBHN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.07302 GSE84922,GSE84924_0_v_3_sall4_mouse RummaGEO Gene Perturbation Signatures -1.0 null L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.80409 SW837_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 4.01871 GSE206516,GSE206518_3_v_4_ptdss2_human RummaGEO Gene Perturbation Signatures -1.0 null GSE110178_5_v_0_tranylcypromine_mouse RummaGEO Drug Perturbation Signatures -1.0 null Cervical carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 POLR2AphosphoS5_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.43307 GSE206226_0_v_1_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_bone marrow_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-UTHO-0006-SM-3NMCC GTEx Tissue Sample Gene Expression Profiles 1.0 1.51352 skeletal system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE221577_4_v_5_pik3r1_human RummaGEO Gene Perturbation Signatures 1.0 null MPP-89 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -1.76633 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.333 ZNF311 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.19871 H3K4me3_cardiac mesoderm_hg19_6 ENCODE Histone Modification Site Profiles 1.0 null COLO-205 Sanger Dependency Map Cancer Cell Line Proteomics 1.0 2.08281 FC-13-VS25_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.3457 MYBL2-22936984-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CTCF_kidney_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ZEB1_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE226584,GSE226589_2_v_0_ezh2_human RummaGEO Gene Perturbation Signatures -1.0 null CTCF_fibroblast of pedal digit skin_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pyramus (VIII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.83763 FOSL2 ENCODE Transcription Factor Targets 1.0 null esophagus_5c HPA Tissue Sample Gene Expression Profiles 1.0 1.02109 MT-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles 1.0 null H3K27ac_fibroblast of lung_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POU5F1-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K36me3_megakaryocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE203429_0_v_1_angptl8_human RummaGEO Gene Perturbation Signatures -1.0 null SPI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC5668942-supp_gr.216721.116_Supplemental_Data_S2.xlsx-Artery_Tibial_IR-TE-SRCAP_SRCAP Rummagene Transcription Factor Associations 2026 1.0 null H3K4me1_HeLa-S3_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-L1-A7W4-01A-12R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.68926 GSE142210_3_v_7_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null NCIH1385 CCLE Cell Line Gene CNV Profiles 1.0 1.53421 GTEX-SNMC-1026-SM-4DM7K GTEx Tissue Sample Gene Expression Profiles 1.0 1.06065 CREB1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-U3ZG-0326-SM-47JXN GTEx Tissue Sample Gene Expression Profiles -1.0 -1.20673 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A7IN-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Perturb_14501_KO_Tgfb3_SRP020224 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 3.20671 7564_RRP1_P1P2 Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures 1.0 1.02384 CCND1-20090754-RETINA-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_foreskin fibroblast_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null CTNNB1-20615089-FETAL-BRAIN-HUMAN ChEA Transcription Factor Targets 2022 1.0 null HBE cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.786 midline nuclear complex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.935211 SARS-CoV MA15_Day1-PFU-10^4_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.09355 GTEX-XQ3S-0526-SM-4BOQA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.00234 TAF1_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null A2058 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.57117 lateral habenular nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.59527 GTEX-PWCY-0226-SM-48TD8 GTEx Tissue Sample Gene Expression Profiles 1.0 1.37176 GTEX-RVPU-0011-R1A-SM-2XCAI GTEx Tissue Sample Gene Expression Profiles -1.0 -2.22001 IC-28-HS37_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.225654 leukemia cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.239913 Bone marrow disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.366 GTEX-XMD1-0011-R1A-SM-4AT4C GTEx Tissue Sample Gene Expression Profiles -1.0 -0.958447 AE-95-UU45_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.396458 Acute lymphoblastic leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.431 ZEB1 ENCODE Transcription Factor Targets 1.0 null GSE120612_7_v_5_etoposide_human RummaGEO Drug Perturbation Signatures -1.0 null Brain Lower Grade Glioma_LGG_TCGA-R8-A73M-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null abducens nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.3168 WC-09-GD62_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.03644 HCFC1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pharynx TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 superficial stratum of THyB-D Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.7685 ETS1 ChEA Transcription Factor Targets 1.0 null YY1-26981420-C2C12-MOUSE-MUSCLE ChEA Transcription Factor Targets 2022 1.0 null intracellular organelle COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 H3K4me3_fibroblast of mammary gland_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE154219_0_v_2_cholestyramine_mouse RummaGEO Drug Perturbation Signatures 1.0 null 2545_EIF3B_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.500939 Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5098-01A-01R-1420-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SAGA complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.352 MXI1_IMR-90_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.20597 p1 part of the substantia nigra reticulata Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17385 GSE112765,GSE112767_1_v_0_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null RUNX3_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_B cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Perturb_6585_KO_Clpp_SRP114840 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.96354 Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV2-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.848445 HD-51-KD29_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.46705 GTEX-R55D-0006-SM-3GIJS GTEx Tissue Sample Gene Expression Profiles 1.0 1.11686 USF2_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HC-74-HM63_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.315528 GTEX-WRHK-1626-SM-3MJFH GTEx Tissue Sample Gene Expression Profiles -1.0 -0.91719 SCCOHT1 DepMap CRISPR Gene Dependency 1.0 3.25285 6024_PABPC1_P1P2 Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures 1.0 0.567551 PMC12178937-mmc6.xlsx-L_AKAP12_KDvsD_AKAP12_KD_deg_al-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null MAX_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE111385_2_v_1_tgfbr2_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE148066,GSE157787_8_v_10_n4bp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me1_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CTCF_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null orbital frontal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.49836 H3K4me1_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040367 CORL95 CCLE Cell Line Gene Expression Profiles -1.0 -2.25609 GSE105170,GSE105175_1_v_0_dhx36_human RummaGEO Gene Perturbation Signatures 1.0 null hsa-miR-4419a TargetScan Predicted Conserved microRNA Targets 1.0 1.26663 GSE242199_6_v_0_ntrk2_human RummaGEO Gene Perturbation Signatures 1.0 null GTEX-P4PQ-0326-SM-2HMJ8 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.22399 BRCA1_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XYKS-0008-SM-4BRW6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.09669 TCF7L2_HCT116_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null IRF8-22096565-GC-B-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null r6 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.2641 POLR2AphosphoS5_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null primary visual cortex (striate cortex, area V1/17)_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.22304 tuberal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76523 mediodorsal nucleus of thalamus_13 pcw_F_12834 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.12647 SREBF2 ChEA Transcription Factor Targets 1.0 null HNF1A-27111144-CD8+TCELLS-MOUSE-BLOOD-LYMPHOMA ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS5_GM12891_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CTCF_K562_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LMSU CCLE Cell Line Gene CNV Profiles 1.0 1.79496 H2AFZ_myotube_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K36me3_Fetal Lung Roadmap Epigenomics Histone Modification Site Profiles 1.0 null NCI-H460 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.7 CEBPD_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null r4 part of dorsal cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.50549 GSE128634,GSE128636_4_v_5_foxo1_human RummaGEO Gene Perturbation Signatures -1.0 null GSE235390_4_v_2_lurbinectedin_human RummaGEO Drug Perturbation Signatures -1.0 null GABPA_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-44-2655-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE211128_4_v_0_angptl4_human RummaGEO Gene Perturbation Signatures -1.0 null HCT-15 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K36me3_keratinocyte_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null cation binding GO Molecular Function Annotations 2015 1.0 null RCOR1_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Enterovirus 71_8Hour_None_GSE15323 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.24191 H3K4me3_mammary epithelial cell_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null 496100453_HIP_possible Alzheimer's disease_no TBI_88_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.01807 NTERA-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.24163 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040552 GTEX-N7MS-0426-SM-2YUN6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.71165 MCC142 DepMap CRISPR Gene Dependency 1.0 3.45505 GTEX-Q2AI-0426-SM-48U13 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.09857 lower limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.10107 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A5UA-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CHD2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH650_LUNG CCLE Cell Line Proteomics 1.0 3.27632 SIN3A_PFSK-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null L-363 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -3.61978 G122 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.20746 negative regulation of autophagosome maturation GO Biological Process Annotations 2023 1.0 null GSE142210_11_v_5_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null 496100413_FWM_probable Alzheimer's disease_no TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.01108 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null YY1_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_proteinGroups-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null MDAMB436 CCLE Cell Line Gene Expression Profiles 1.0 2.24068 Cortical amygdalar area, posterior part, medial zone, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.78526 496100278_FWM_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.63997 GTEX-XPVG-2226-SM-4B65U GTEx Tissue Sample Gene Expression Profiles 1.0 0.959144 AC-93-LT43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.23779 GTEX-O5YW-0326-SM-2I5EI GTEx Tissue Sample Gene Expression Profiles -1.0 -1.50476 PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-XGQ4-0008-SM-4AT3Z GTEx Tissue Sample Gene Expression Profiles 1.0 1.93486 GTEX-Q2AG-0011-R9A-SM-2HMJ6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.38409 GTEX-PWOO-1026-SM-48TCN GTEx Tissue Sample Gene Expression Profiles 1.0 0.956266 H3K4me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TP53-22127205-IMR90-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null vertebrate muscular system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Liver Neoplasms CTD Gene-Disease Associations 1.0 1.04389 TD-29-IN36_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.11346 CCRF-CEM COSMIC Cell Line Gene Mutation Profiles 1.0 null BA-56-QV45_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.66843 Myeloid neoplasm DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.154 doxorubicin_homo sapiens_gpl550_gds846 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null NCI-H2106 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.23832 KDM1A ENCODE Transcription Factor Targets 1.0 null ME1 CCLE Cell Line Gene CNV Profiles -1.0 -1.68511 TIGD7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.11534 lateral hypothalamic area, mammillary region, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.02808 GABPA_HL-60_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RELA ENCODE Transcription Factor Targets 1.0 null GTEX-T6MN-0526-SM-32PMS GTEx Tissue Sample Gene Expression Profiles -1.0 -1.48201 SCLC-21H Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.925548 GTEX-P44H-0426-SM-2XCEZ GTEx Tissue Sample Gene Expression Profiles -1.0 -1.93002 GTEX-Q2AH-0005-SM-33HBR GTEx Tissue Sample Gene Expression Profiles 1.0 1.5911 HC-74-HM63_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.479002 cochlear nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.848354 Perturb_7153_KD_MOV10_SRP029367 PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 1.31044 SIN3A_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K79me2_IMR90 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-2Z-A9J7-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2106 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -0.945411 nucleus incertus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0425 RUNX2_NULL MUTATION_GDS2184_719_mouse_Embryonal bone (MG-U74A) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null H3K4me3_brain microvascular endothelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null FOXP3-21729870-TREG-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null KDM2B-26808549-CHIP-SEQ-SIL-ALL-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GSE186287_2_v_3_ufm1_human RummaGEO Gene Perturbation Signatures 1.0 null Duchenne muscular dystrophy (DMD)_Extraocular muscle_GSE1472 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.51043 GTF2F1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null bonemarrow_6c HPA Tissue Sample Gene Expression Profiles -1.0 -1.38381 Prostate adenocarcinoma_PRAD_TCGA-KC-A4BN-01A-61R-A250-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PHF8 ENCODE Transcription Factor Targets 1.0 null 2-iminoacetate synthase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.763 POLR2A_GM18951_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AIRE_KO_GDS2274_246_mouse_Medullary thymic epithelial cells (with high CD80 expression) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Bed nucleus of the accessory olfactory tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26956 dorsal cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.45622 GSE159893_2_v_0_genistein_human RummaGEO Drug Perturbation Signatures -1.0 null H3K4me3_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2 Rummagene Transcription Factor Associations 2026 1.0 null H3K4me3_fibroblast of upper leg skin_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC12178384-mmc6.xlsx-Sheet1-Supp_Table_4_Differential_expression_analysis_of_CIC-rearranged_sarcomas_vs_CIC-rearranged-like_sarcomas_CIC Rummagene Transcription Factor Associations 2026 1.0 null NR2F2_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-QDT8-3026-SM-32PKB GTEx Tissue Sample Gene Expression Profiles -1.0 -0.856159 CA-68-KG29_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.3899 PMC12486367-Supplementary_Data2.pdf-272-RFX2_RFX2 Rummagene Transcription Factor Associations 2026 1.0 null E2F4_MCF 10A_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null molecular_function GO Molecular Function Annotations 2015 1.0 null GTEX-WFG8-0726-SM-3GILP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.981036 HER2_OE_GDS4763_331_human_MCF10A - immortalized breast epithelial cell line GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A42C-01A-11R-A23N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null negative regulation of autophagosome assembly GO Biological Process Annotations 2025 1.0 null SH2B2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.23631 r9 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08215 PrefrontalCortex BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.72194 H3K4me3_WERI-Rb-1_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-ER-A2ND-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SLC16A5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11311 valproic acid_homo sapiens_gpl6883_gse26940 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null GSE142684_0_v_5_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null occipital neocortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.08506 GSE233679_6_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null JD-81-YX02_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -1.63677 ZNF280C CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.39148 hematologic cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.524202 nes HPA Cell Line Gene Expression Profiles 1.0 1.22075 DA-10-ZX00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.528229 H3K4me3_MEL cell line_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null TAF1_neural cell_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Np TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.717 POLR2A_HeLa-S3_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTF2F1 ENCODE Transcription Factor Targets 1.0 null Prostate adenocarcinoma_PRAD_TCGA-KK-A8IL-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null eGFP-JUNB_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CEBPB ChEA Transcription Factor Targets 1.0 null T-cell chronic lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 WC-16-IR43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.348639 GTEX-SNOS-0626-SM-4DM5F GTEx Tissue Sample Gene Expression Profiles 1.0 0.878441 hsa-miR-548z TargetScan Predicted Conserved microRNA Targets 1.0 0.193083 H3K4me3_BE2C_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H4K20me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GTEX-OXRK-0126-SM-3NB1E GTEx Tissue Sample Gene Expression Profiles 1.0 2.64345 pyrazinamide_mus musculus_gpl6246_gse48027 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MAX_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null LN18 CCLE Cell Line Gene Expression Profiles 1.0 1.63258 OC-10-FB51_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.553378 intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4U-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NUDT16 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.09418 RAD21_MEL cell line_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CCND1 ChEA Transcription Factor Targets 1.0 null NCIH196 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.12829 GSK3B_knockdown_158_GSE35351 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.37612 Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10691 caudal ganglionic eminence_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 0.931294 H2AFZ_mammary epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null AP-1 MotifMap Predicted Transcription Factor Targets 1.0 null SP1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NOP10 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11978 FOS_MCF 10A_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S7PM-0008-SM-3NM9Q GTEx Tissue Sample Gene Expression Profiles 1.0 1.29512 r9 part of external cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.8819 G401 CCLE Cell Line Gene Expression Profiles 1.0 1.71887 SAP30_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)PB1-F2del_1day-MOI-10^3_None_GSE43302 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -2.0079 ELF1_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null STAT4 ChEA Transcription Factor Targets 1.0 null GTEX-QLQ7-0008-SM-447AW GTEx Tissue Sample Gene Expression Profiles 1.0 0.987684 H3K27ac_A549_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null organ system cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.231795 Mobilized_CD34_Primary_Cells_Female Roadmap Epigenomics Cell and Tissue Gene Expression Profiles -1.0 -0.929222 Disease of anatomical entity DISEASES Experimental Gene-Disease Association Evidence Scores 2025 1.0 1.601 gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 supramarginal gyrus, right, superior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.965832 GTEX-XUJ4-0005-SM-4BOQ6 GTEx Tissue Sample Gene Expression Profiles 1.0 1.73691 chronic myeloid leukemia cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.174443 MYC_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3YO-06A-11R-A239-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null blood TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.061348 dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.4753 AOB, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.01958 GTEX-PWN1-0008-SM-48TEA GTEx Tissue Sample Gene Expression Profiles 1.0 0.932215 PPP1R12A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.14863 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3M9-01A-11R-A213-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE200673,GSE200691_2_v_3_hmga2_mouse RummaGEO Gene Perturbation Signatures -1.0 null frontal lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 POLR2A_GM18505_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null A2058 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.46394 KLF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 158.692 H3K4me3_HepG2_hg19_3 ENCODE Histone Modification Site Profiles 1.0 null GSE233679_14_v_1_nicotinamide_human RummaGEO Drug Perturbation Signatures -1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-A6K1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-XUYS-0326-SM-47JX2 GTEx Tissue Sample Gene Expression Profiles -1.0 -2.11787 RBBP5_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null FOXL1 JASPAR Predicted Transcription Factor Targets 1.0 null COPS6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.45468 BB-87-SF89_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.51783 GTEX-WFON-0226-SM-3GIKR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.23101 dorsomedial preoptic area, superficial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00806 superficial stratum of r4BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01737 GSE158834_10_v_4_palm_human RummaGEO Gene Perturbation Signatures -1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UE-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 RUNX2-24655370-MC3T3E1-MOUSE-BONE ChEA Transcription Factor Targets 2022 1.0 null ZIC4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 77.0476 MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.922439 H3K4me3_skeletal muscle cell_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null PMC8650352-JCB_202012097_DataS1.xlsx-VHL_KD_filteredProteinGroups-Gene_names_AR Rummagene Transcription Factor Associations 2026 1.0 null Rectum adenocarcinoma_READ_TCGA-DC-5337-01A-01R-1660-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POU2F2_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GLIS1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.6597 TBP_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Plant cuticle TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.684 Brain Lower Grade Glioma_LGG_TCGA-P5-A735-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE112761,GSE112767_2_v_3_ddx6_mouse RummaGEO Gene Perturbation Signatures 1.0 null superficial stratum of r3BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.96975 GSE159728,GSE159730_0_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null HCC827 CCLE Cell Line Gene CNV Profiles 1.0 1.51487 H3K4me3_epithelial cell of proximal tubule_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null cortico-medial group, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.00312 EGR1-20690147-ERYTHROLEUKEMIA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_4_FDC-Gene_FOXK2 Rummagene Transcription Factor Associations 2026 1.0 null GATA3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null AD-18-XC14_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.363123 GSE160246_9_v_5_cpeb4_mouse RummaGEO Gene Perturbation Signatures -1.0 null A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_3Hour_None_GSE43203 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.32917 GTEX-N7MT-0007-SM-3GACQ GTEx Tissue Sample Gene Expression Profiles 1.0 0.909925 GTEX-OOBJ-1026-SM-3NB2L GTEx Tissue Sample Gene Expression Profiles -1.0 -1.9445 GTEX-WHPG-1026-SM-3NMBA GTEx Tissue Sample Gene Expression Profiles -1.0 -1.18697 SF268 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.44502 arm TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.424963 Prostate GTEx Tissue Gene Expression Profiles 2023 1.0 3.18466 KMS-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.08744 BD-49-MD69_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -8.40016 BA-84-WN26_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.59592 POLR2A_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Disease of cellular proliferation DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.655 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00655 H3K79me2_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.882718 RAD21_MEL cell line_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JUN_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null hematopoietic cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null NCIH716_LARGE_INTESTINE CCLE Cell Line Proteomics 1.0 9.66706 Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HT-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07695 CHD1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.513683 PBX3_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me1_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of r10Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03285 NUGC-4 Sanger Dependency Map Cancer Cell Line Proteomics -1.0 -2.89178 KG1 CCLE Cell Line Gene CNV Profiles -1.0 -1.32194 AC-47-YZ27_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.82652 GTEX-U3ZN-1426-SM-3DB87 GTEx Tissue Sample Gene Expression Profiles -1.0 -0.907684 GTEX-SE5C-0006-SM-4BRW5 GTEx Tissue Sample Gene Expression Profiles 1.0 2.72469 Perturb_14969_KD_Phf23_SRP248452 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -20.0 NE-20-WM78_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.22078 PIH1D1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.03421 GTEX-TMZS-0006-SM-3DB8G GTEx Tissue Sample Gene Expression Profiles 1.0 1.17034 paraventricular nuclei, left of thalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.861759 FB-66-UU47_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.609892 ZBTB6 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.11677 PMC4149371-pone.0105180.s010.xls-SOX2-GENE_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null NCIH2081 CCLE Cell Line Gene Expression Profiles -1.0 -1.73277 FLI1 ENCODE Transcription Factor Targets 1.0 null H3K36me3_cardiac mesoderm_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null SG in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07184 CTCF_MEL cell line_mm9_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null tail of caudate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.08608 MXI1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null non-membrane-bounded organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.046199 GTEX-OIZH-1326-SM-3NB1H GTEx Tissue Sample Gene Expression Profiles 1.0 2.47596 piriform cortex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.7392 H3K4me3_H7_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CA-75-HA22_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.320972 H3K4me3_epithelial cell of esophagus_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null GSE203158_5_v_15_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null H3K4me3_GM12864_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null H3K4me1_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GATA4-21415370-HL-1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null POLR2AphosphoS2_myocyte_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PML_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null dorsal cochlear nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.29265 GABPA_HL-60_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hematopoietic system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.2603 SIX5 ENCODE Transcription Factor Targets 1.0 null cervical carcinoma cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null WC-09-GD62_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.878737 PMC7681055-ACEL-19-e13226-s014.xlsx-Sheet1-Ryk-independent_FOXO3_targets_FOXO3 Rummagene Transcription Factor Associations 2026 1.0 null AP-2rep MotifMap Predicted Transcription Factor Targets 1.0 null T-cell acute lymphoblastic leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.212 GTEX-XBED-1926-SM-47JYP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.901424 H3K4me3_epithelial cell of proximal tubule_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Cortical amygdalar area, posterior part, medial zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49236 cerebellar nuclei of CbV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31163 COLO677 CCLE Cell Line Gene Expression Profiles -1.0 -1.5784 ELF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.2972 IRF8 ChEA Transcription Factor Targets 1.0 null KF-18-RY71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.77881 hsa-miR-580 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null nucleus COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 Gastrointestinal tract TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 intermediate stratum of r10BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36822 WC-16-IR43_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.323443 nuclear part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041719 GTEX-WYJK-0826-SM-3NM8Y GTEx Tissue Sample Gene Expression Profiles -1.0 -0.872993 r8 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94713 Lung squamous cell carcinoma_LUSC_TCGA-43-6771-01A-11R-1820-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GABPA_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null brain stem TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 Leukemic stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.021 intracellular part COMPARTMENTS Experimental Protein Localization Evidence Scores 1.0 0.233497 GTEX-OIZF-0006-SM-2I5GQ GTEx Tissue Sample Gene Expression Profiles 1.0 1.82363 PMC3889689-elife01439s001.xls-RFX2_rnaseq_chip_DirectDE_final-GeneName_RFX2 Rummagene Transcription Factor Associations 2026 1.0 null RSV_24Hour_19459069_GSE3397 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.65349 Pontine central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14035 H3K4me3_CD14-positive monocyte_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null CEBPB ENCODE Transcription Factor Targets 1.0 null hsa-miR-4736 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 MAPACHS77 DepMap CRISPR Gene Dependency 1.0 2.05625 HCC366 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.983699 Lung adenocarcinoma_LUAD_TCGA-73-4666-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE99875_2_v_0_everolimus_human RummaGEO Drug Perturbation Signatures -1.0 null PPP1R8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.28771 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A3HE-01A-21R-A22U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE142210_9_v_6_panobinostat_human RummaGEO Drug Perturbation Signatures -1.0 null HCC4006 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.972547 hematopoietic stem cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.230931 GTEX-QEG4-1226-SM-2S1P6 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.24004 H3K4me3_cardiac muscle cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_7_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null SFPI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null POLR2A_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE165548_2_v_7_gemcitabine_human RummaGEO Drug Perturbation Signatures -1.0 null GSE126463_4_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null Nucleus prepositus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.13115 negative regulation of autophagosome maturation GO Biological Process Annotations 2025 1.0 null 496100474_FWM_possible Alzheimer's disease_TBI_89_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -2.08845 regulation of protein ubiquitination GO Biological Process Annotations 2025 1.0 null JB-75-NC66_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.431765 YY1_SK-N-SH_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null MBD4 ENCODE Transcription Factor Targets 1.0 null IMP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.02321 KLF9 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 56.4902 Brain Lower Grade Glioma_LGG_TCGA-DU-5854-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors -1.0 null OVKATE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.5116 GSE158834_0_v_13_palm_human RummaGEO Gene Perturbation Signatures -1.0 null LRSAM1 Pathway Commons Protein-Protein Interactions 1.0 null H3K36me3_cardiac mesoderm_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-34-5241-01A-01R-1443-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null central nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -3.31005 rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.89355 r10 part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03366 GTEX-U4B1-0526-SM-4DXTK GTEx Tissue Sample Gene Expression Profiles 1.0 1.01218 nucleus LOCATE Predicted Protein Localization Annotations 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A560-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null periventricular stratum of r7Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4435 PMC5291205-srep41905-s3.xlsx-LPS_datasets_gmx-Unnamed_4_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null GSE203308_7_v_5_brf1_mouse RummaGEO Gene Perturbation Signatures 1.0 null POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S32W-0626-SM-2XCBG GTEx Tissue Sample Gene Expression Profiles -1.0 -0.86578 colo824 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.16 pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.480275 Kidney renal papillary cell carcinoma_KIRP_TCGA-4A-A93X-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CF-87-AS90_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -3.14565 GTEX-T2IS-2626-SM-32QPP GTEx Tissue Sample Gene Expression Profiles -1.0 -1.62397 Nuclear pore COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.501 GTEX-TKQ1-0008-SM-4DXSO GTEx Tissue Sample Gene Expression Profiles 1.0 1.50813 retrotrapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28813 BE-13-XC52_0.01uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.237241 KP1N DepMap CRISPR Gene Dependency 1.0 2.66532 GSE146612_1_v_3_amiodarone_human RummaGEO Drug Perturbation Signatures 1.0 null Neoplasm Metastasis CTD Gene-Disease Associations 1.0 1.09998 PMC7592539-12885_2020_7456_MOESM4_ESM.xlsx-Sup_TableS3_LMS_del_genes_conf-17p13_1_TP63 Rummagene Transcription Factor Associations 2026 1.0 null GTEX-S95S-0726-SM-4B64H GTEx Tissue Sample Gene Expression Profiles -1.0 -1.44182 GSE131649_6_v_10_hemin_human RummaGEO Drug Perturbation Signatures 1.0 null SUDHL5 DepMap CRISPR Gene Dependency 1.0 3.20406 blood TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Infection by Yersinia enterocolitica_macrophage_GSE2973 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -2.09058 GSE158834_1_v_13_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null MYC ChEA Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D9-A1X3-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAF7_H1-hESC_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-OIZI-1126-SM-3NB1F GTEx Tissue Sample Gene Expression Profiles -1.0 -0.922798 GSE110708_1_v_3_adar_mouse RummaGEO Gene Perturbation Signatures 1.0 null GTEX-W5WG-1126-SM-4LMK4 GTEx Tissue Sample Gene Expression Profiles 1.0 1.26619 HUH-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07011 hindbrain TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 CTCF_MEL cell line_mm9_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-S3XE-1526-SM-4AD5A GTEx Tissue Sample Gene Expression Profiles 1.0 0.917358 GTEX-WFON-1126-SM-4LVMA GTEx Tissue Sample Gene Expression Profiles -1.0 -0.96651 skeletal muscle TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 PMC12178937-mmc6.xlsx-L_MT1_KDvsD_MT1_KD_deg_all-gene_id_AR Rummagene Transcription Factor Associations 2026 1.0 null r7 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27232 NFIC_HepG2_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.31343 K-562 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.05747 NCIH2004RT DepMap CRISPR Gene Dependency 1.0 2.40303 Lymphocyte percentage of white cells GWAS Catalog SNP-Phenotype Associations 2025 1.0 1.8301 hsa-miR-484 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.880544 GSE223540_1_v_3_anxa2_mouse RummaGEO Gene Perturbation Signatures 1.0 null SIN3A_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null NRF1_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null 15735024-SuppTable2 GeneSigDB Published Gene Signatures 1.0 null GSE125014_6_v_5_enzalutamide_human RummaGEO Drug Perturbation Signatures 1.0 null POLR2A_GM12891_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null HE-80-BQ08_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.545376 GSE179974_3_v_4_carboplatin_mouse RummaGEO Drug Perturbation Signatures 1.0 null GTEX-R55E-0526-SM-2TC6B GTEx Tissue Sample Gene Expression Profiles -1.0 -1.47651 H3K36me3_cardiac mesoderm_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null G61 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.57833 GSE200388_0_v_1_gemin5_human RummaGEO Gene Perturbation Signatures -1.0 null GSE168797_1_v_6_cannabidiol_human RummaGEO Drug Perturbation Signatures 1.0 null PMC7468443-Data_Sheet_5.xlsx-LPS_2h_over_6h-Unnamed_7_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null Entorhinal area, medial part, ventral zone, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41498 PPM1D CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.0393 TCF12_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GSE226249_0_v_3_pirfenidone_human RummaGEO Drug Perturbation Signatures 1.0 null BHLHE40_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-WEY5-0008-SM-4LMKC GTEx Tissue Sample Gene Expression Profiles 1.0 0.931228 GTEX-QDVJ-1126-SM-48U1U GTEx Tissue Sample Gene Expression Profiles 1.0 2.21704 GSE98964_1_v_4_tet2_mouse RummaGEO Gene Perturbation Signatures 1.0 null Skeletal Muscle Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles 1.0 2.12359 CTCF_fibroblast of villous mesenchyme_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null KYSE220 DepMap CRISPR Gene Dependency 1.0 2.19192 H3K9ac_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2AphosphoS5_GM12878_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null RMSYM DepMap CRISPR Gene Dependency 1.0 2.13126 GTEX-P4PQ-0005-SM-2HMKJ GTEx Tissue Sample Gene Expression Profiles 1.0 0.853682 GATA2 JASPAR Predicted Transcription Factor Targets 1.0 null GTEX-R55F-1526-SM-2TF4X GTEx Tissue Sample Gene Expression Profiles -1.0 -1.12156 SMC3_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PRKAA1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.04212 plant TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.546929 paracentral lobule, anterior part, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.94534 GSE216273,GSE216292_0_v_3_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null H3K4me3_fibroblast of pulmonary artery_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SG in medial temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.27438 TCF3-18347094-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null oculomotor nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.97598 GSE102505_4_v_0_tunicamycin_human RummaGEO Drug Perturbation Signatures -1.0 null PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR Rummagene Transcription Factor Associations 2026 1.0 null GSE153871_4_v_2_cytarabine_human RummaGEO Drug Perturbation Signatures -1.0 null GTEX-R55E-1026-SM-2TC5S GTEx Tissue Sample Gene Expression Profiles -1.0 -0.921848 Lung adenocarcinoma_LUAD_TCGA-86-8281-01A-11R-2287-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE115395_2_v_4_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null 3554_GSPT1_P1P2 Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures 1.0 0.514452 USF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SALL4 ChEA Transcription Factor Targets 1.0 null superficial stratum of TSPaA Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21147 primary somatosensory cortex (area S1, areas 3,1,2)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -0.880429 Prostate adenocarcinoma_PRAD_TCGA-KK-A8I5-01A-11R-A36G-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FOSL2_HepG2_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null H3K4me3_cerebellum_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC6225799-annrheumdis-2018-213524supp003.xlsx-Activated-state-LPS-Gene_Symbol_IRF6 Rummagene Transcription Factor Associations 2026 1.0 null upper limb region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3742 GTEX-QEG4-0626-SM-2S1OY GTEx Tissue Sample Gene Expression Profiles -1.0 -2.42863 GSE195513_0_v_3_cpeb1_mouse RummaGEO Gene Perturbation Signatures 1.0 null EGR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_ECC-1_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null TOV-112D Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.07011 GTEX-P44H-0726-SM-48TBT GTEx Tissue Sample Gene Expression Profiles -1.0 -1.16102 GSE139455_4_v_5_stat3_human RummaGEO Gene Perturbation Signatures 1.0 null GI1 DepMap CRISPR Gene Dependency 1.0 2.41056 AA-58-FJ71_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.846596 Lymph node TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 GTEX-WHWD-0005-SM-3LK7D GTEx Tissue Sample Gene Expression Profiles 1.0 0.90765 Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5178-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GTEX-SIU8-0008-SM-4BRUC GTEx Tissue Sample Gene Expression Profiles 1.0 1.45104 GTEX-S4P3-0626-SM-4AD59 GTEx Tissue Sample Gene Expression Profiles -1.0 -1.06455 hsa-miR-24 TargetScan Predicted Conserved microRNA Targets 1.0 0.568687 LRRC59 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.18763 GSE130246_1_v_3_enzalutamide_human RummaGEO Drug Perturbation Signatures -1.0 null CRX ChEA Transcription Factor Targets 1.0 null H3K4me3_brown adipose tissue_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null striatum_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq -1.0 -1.21262 POLR2AphosphoS5_GM12892_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BE-79-QU25_0.1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.259164 KLF4-18358816-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null EGR1_MCF-7_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null hsa-miR-4780 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.55165 dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.51295 USF1_A549_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-VUSG-1526-SM-4KKZH GTEx Tissue Sample Gene Expression Profiles 1.0 1.2006 NCI-H2722 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 0.997544 hsa-miR-125b TargetScan Predicted Conserved microRNA Targets 1.0 0.274552 GTEX-OIZI-0626-SM-2XCEH GTEx Tissue Sample Gene Expression Profiles -1.0 -2.94195 lymphnode_5b HPA Tissue Sample Gene Expression Profiles 1.0 1.33476 H3K79me2_C2C12_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GSE158834_2_v_4_palmitic acid_human RummaGEO Drug Perturbation Signatures -1.0 null POLR2A_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null B-lymphoblastic leukemia/lymphoma DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.235 wt1_00000000_mouse_embryonic_fibroblast_mef_lof_mouse_gpl1261_gse15325 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.928385 COLO 829 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 1.7134 GSE108326_1_v_0_doxycycline_mouse RummaGEO Drug Perturbation Signatures 1.0 null GSE182680,GSE182683_7_v_6_dexamethasone_human RummaGEO Drug Perturbation Signatures -1.0 null QA-07-KC40_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.299825 periventricular stratum of r2Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47521 hsa-miR-3647-5p TargetScan Predicted Nonconserved microRNA Targets 1.0 1.07142 GSE120413,GSE120447_0_v_5_bap1_mouse RummaGEO Gene Perturbation Signatures 1.0 null GSE203158_12_v_15_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null MYC-19030024-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Perturb_6132_OE_Tfeb_SRP157662 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -4.6867 GTEX-S33H-0126-SM-4AD62 GTEx Tissue Sample Gene Expression Profiles 1.0 0.991923 KMS-28PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.11502 HDDC3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.19166 DEOC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles 1.0 2.37872 intracellular membrane-bounded organelle GO Cellular Component Annotations 2023 1.0 null nod2_21335489_hek293_lof_human_gpl570_gds4416 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.96607 H3K36me3_bronchial epithelial cell_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAFK_HeLa-S3_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6343-01A-21R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Primary hyperoxaluria type 1 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.2 GSE158834_1_v_8_palm_human RummaGEO Gene Perturbation Signatures 1.0 null LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.8699 superficial stratum of PHyB-V Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.49486 ELF1_SK-N-SH_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EP300_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-OIZF-1526-SM-3MJGY GTEx Tissue Sample Gene Expression Profiles -1.0 -0.923492 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-11A-11R-A18C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TBL1XR1_GM12878_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-XPT6-1626-SM-4B655 GTEx Tissue Sample Gene Expression Profiles 1.0 0.930342 MET_knockout_259_GSE25583 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.312 Bronchus TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 FLI1_megakaryocyte_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null XD-44-FJ34_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.329867 CREB1-23762244-HIPPOCAMPUS-RAT ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me3_fibroblast of mammary gland_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null Lung squamous cell carcinoma_LUSC_TCGA-21-1078-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE162892_4_v_0_isox_human RummaGEO Drug Perturbation Signatures -1.0 null ELF1_A549_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ATF3_A549_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Stomach TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.017 H3K36me3_erythroblast_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null leukocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.065982 GSE126463_1_v_2_pomalidomide_human RummaGEO Drug Perturbation Signatures -1.0 null NCIH1703 DepMap CRISPR Gene Dependency 1.0 3.06383 TBP-23326641-C3H10T1-2-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null dorsolateral prefrontal cortex_9 pcw_M_12833 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.62889 parietal neocortex_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq 1.0 1.73146 hsa-miR-4704-5p TargetScan Predicted Conserved microRNA Targets 1.0 1.11641 SE-15-AV21_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.410602 H3K36me3_HeLa-S3_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.53602 GTEX-QMR6-0008-SM-447AV GTEx Tissue Sample Gene Expression Profiles 1.0 1.27047 EHF JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.379 COV362 CCLE Cell Line Gene Expression Profiles -1.0 -1.75402 MYC_NB4_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null CDCP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.1801 DHX36 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.37456 KIF2A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.07947 GTEX-RVPU-2426-SM-2XCAR GTEx Tissue Sample Gene Expression Profiles -1.0 -1.37969 RUNX3 ENCODE Transcription Factor Targets 1.0 null r4 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.64567 BHLHE40_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PU.1-20176806-MACROPHAGES-MOUSE ChEA Transcription Factor Targets 2022 1.0 null A10 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.126 GTEX-X4LF-0006-SM-3NMCO GTEx Tissue Sample Gene Expression Profiles 1.0 1.51853 COLO 678 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles -1.0 -1.09138 r6 part of the cochlear column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.43291 GTEX-QCQG-0126-SM-48U27 GTEx Tissue Sample Gene Expression Profiles 1.0 0.864593 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AG-06A-31R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute leukemia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.547 Cell type cancer DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.101 dorsolateral part of Int Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01413 H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null GSE193258,GSE193259_2_v_4_osimertinib_human RummaGEO Drug Perturbation Signatures 1.0 null Brain Lower Grade Glioma_LGG_TCGA-P5-A72W-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A5TU-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Dorsal column nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38603 CST complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.836 SNU886 CCLE Cell Line Gene CNV Profiles -1.0 -1.44283 Head and Neck squamous cell carcinoma_HNSC_TCGA-F7-A61W-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD-47-YL43_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.23791 superficial stratum of r2BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.64875 DMS454 CCLE Cell Line Gene Expression Profiles -1.0 -2.69234 GSE192663_1_v_5_acly_mouse RummaGEO Gene Perturbation Signatures -1.0 null lymphocytic leukemia cell TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GTEX-SN8G-0008-SM-4DM4X GTEx Tissue Sample Gene Expression Profiles 1.0 1.06274 whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 0.766457 GSE148066,GSE157787_9_v_4_n4bp1_mouse RummaGEO Gene Perturbation Signatures 1.0 null FD-62-ZB67_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.216749 FOXP3-21729870-TREG-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Hoxa11 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 17.9338 hsa-miR-3153 TargetScan Predicted Nonconserved microRNA Targets 1.0 1.40969 THAP11-20581084-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null GSE119978,GSE180930_2_v_4_cisplatin_human RummaGEO Drug Perturbation Signatures -1.0 null hematopoietic system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.05991 CELF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.38263 H3K4me3_GM06990_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null r10 part of vagal motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08186 GTEX-XMD3-0006-SM-4AT5X GTEx Tissue Sample Gene Expression Profiles 1.0 1.18723 BHY CCLE Cell Line Gene Expression Profiles -1.0 -1.58059 GTEX-OOBK-0005-SM-2YUMG GTEx Tissue Sample Gene Expression Profiles 1.0 1.02697 GSE216273,GSE216292_0_v_2_palbociclib_human RummaGEO Drug Perturbation Signatures 1.0 null NCIH841 CCLE Cell Line Gene Expression Profiles 1.0 2.73383 orbital frontal cortex_2 yrs_F_12979 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.967001 GTEX-WL46-0626-SM-3LK7R GTEx Tissue Sample Gene Expression Profiles -1.0 -1.36096 GSE158834_11_v_4_palm_human RummaGEO Gene Perturbation Signatures -1.0 null hsa-miR-3667-3p TargetScan Predicted Conserved microRNA Targets 1.0 0.997906 POLR2A_A549_hg19_5 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-Q2AH-0226-SM-48U1I GTEx Tissue Sample Gene Expression Profiles 1.0 0.889992 EP300_SK-N-SH_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null liver HPA Tissue Protein Expression Profiles -1.0 -1.61402 PMC9992472-41467_2023_36735_MOESM7_ESM.xlsx-SOX11_ChIP_in_IMR-32-Unnamed_13_SOX11 Rummagene Transcription Factor Associations 2026 1.0 null 496100611_FWM_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles -1.0 -3.44485 PMC10534007-Table_2.xlsx-S6_unique_down_MSC_B-914_elements_included_exclusively_in_BFTC905_MSC_down_MSC Rummagene Transcription Factor Associations 2026 1.0 null HCC44 Achilles Cell Line Gene Essentiality Profiles -1.0 -1.27306 FGFR1_knockdown_94_GSE27869 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 2.0265 rostral division of VL Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.48057 UPCISCC029A DepMap CRISPR Gene Dependency 1.0 2.29253 A4 noradrenergic cell group Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.42515 GSE213588_8_v_3_trametinib_human RummaGEO Drug Perturbation Signatures 1.0 null CCNT2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MAX_K562_hg19_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null POLR2AphosphoS2_CH12.LX_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null GA-59-RW04_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -2.06053 KA-81-AG66_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -4.68297 SEM Achilles Cell Line Gene Essentiality Profiles 1.0 1.09487 GTEX-SE5C-0008-SM-4B64J GTEx Tissue Sample Gene Expression Profiles 1.0 1.06052 UBTF_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null regulation of autophagosome assembly GO Biological Process Annotations 2023 1.0 null periventricular stratum of r8Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.94713 Occipital lobe TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 2.289 Perturb_5821_KD_Pcbp1_SRP324137 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -2.42312 Placenta TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 1.0 1.091 periventricular stratum of r6BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.33445 H3K4me3_B cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null SOD2_KO_GDS1080_128_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null PMC8807392-41375_2021_1393_MOESM2_ESM.xlsx-data_integration-YBX1_iCLIP-targets_YBX1 Rummagene Transcription Factor Associations 2026 1.0 null SmoothMuscle BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.11058 COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.916101 fat_x1.V2 HPA Tissue Sample Gene Expression Profiles -1.0 -0.943948 Lung adenocarcinoma_LUAD_TCGA-J2-8194-01A-11R-2241-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null POLR2AphosphoS5_HCT116_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null JURLMK1 CCLE Cell Line Gene Expression Profiles -1.0 -1.83113 GTEX-QXCU-0926-SM-48FEP GTEx Tissue Sample Gene Expression Profiles -1.0 -0.954873 BB-20-UU03_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles -1.0 -0.203291 H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_K562_hg19_6 ENCODE Transcription Factor Binding Site Profiles 1.0 null GTEX-PWO3-0005-SM-2I5FS GTEx Tissue Sample Gene Expression Profiles 1.0 1.12779 Prostate adenocarcinoma_PRAD_TCGA-M7-A723-01A-12R-A32O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null